Abstract: A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.

Abstract: A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.

Abstract: The invention provides compositions for the inhibition of bacterial adhesion. The composition can include nanocrystalline cellulose (NCC) and a water-soluble polymer, which form an NCC hydrogel in water. The NCC hydrogel can be used to treat or coat devices such as a catheter, whereby the NCC hydrogel inhibits bacterial adhesion to the catheter surface to thereby inhibit biofilm formation and growth of bacteria on the catheter surface. The compositions and devices can thus be useful for inhibiting or preventing conditions such as urinary tract infections.

Abstract: An implant for vascular implantation in a body is provided with a surface which, in the implanted state, is provided for contact with the body or with a bodily fluid and which is at least for the most part hydrated. The surface is advantageously provided as a bare metal surface of a chromium-containing alloy. The vascular implant is used to regulate an adsorption of proteins on the surface of the implant, in respect of the type, quantity and/or conformation of certain proteins, by a defined surface which is at least for the most part hydrated.

Abstract: [Problem] To provide a composition capable of effectively preventing adhesion. [Solution] An adhesion-preventing preparation comprising, as an active ingredient, a composition comprising an A-B-A triblock copolymer, in which A denotes a cationically chargeable polymer block and B denotes a water-soluble block that comprises a poly(ethylene glycol) (or poly(oxyethylene)) chain, and a polyanionic polymer.

Abstract: This invention relates to hydrophilic polymer compositions and a preferred application therefore, viz., hydrophilic medical device coatings. The hyaluronic acid hyaluronon by itself or modified as described herein advantageously reacts with compositions disclosed in U.S. Pat. No. 7,776,956 to produce hydrophilic compositions and coatings particularly useable with medical devices.

Abstract: The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.

Abstract: A vacuum dressing to cover a medical device insertion site, generally comprising a transparent film dressing member, adapted to form a sealed region between the film dressing member and a region of skin surrounding the insertion site; a sponge/foam member adapted to be positioned over the insertion site; and vacuum tubing, wherein the vacuum tubing permits vacuum pressure to be applied to the sealed region.

Abstract: Methods and systems are provided for a sub-atmospheric wound-care (SAWS) system for treating an open wound. The SAWS system includes a regulated vacuum source for developing a negative pressure, a flow rate meter configured to measure a flow rate of liquid removed from the wound, a primary pressure regulating sensor located proximate the wound for directly measuring the negative pressure at the wound, a backup pressure regulating sensor located vacuum tube, a porous dressing suitable to be sealed airtight which is positioned within a wound interface chamber, a collection canister configured to collect said liquid removed from the wound, and an adapter configured to use wall suction a primary regulated vacuum source.

Abstract: A pump and pump controller which uses an algorithm to quickly achieve and maintain a set pressure in a surgical site when high resistance hardware is being used is provided. The algorithm uses a gravity control type loop and uses pressure loss calculations to quickly respond to changing joint conditions. A method of using such a pump and pump controller is also provided.

Abstract: A system for in-vivo and ex-vivo tissue regeneration and cellular control, manipulation and management includes a source of cell manipulating factors, which are administered to a therapy zone via active pressure-differential components including a pump and a controller, or pulse-waves generated passively. A plate comprising tissue or an inert, bio-compatible material is provided in the therapy zone in proximity to a fluid flow manifold and tissue scaffolding. An embodiment of a medical cellular factor control system and method includes an implanted bio-reactor and a force transducer configured for supplying one or more cell-manipulating factors to a therapy zone surrounding the bio-reactor. Optionally, a concave-curved, internal reflector can be implanted in proximity to the bio-reactor, the internal reflector being configured for amplifying pressure waves in the therapy zone.

Abstract: A dressing system is disclosed which has a sponge and a near infrared spectroscopy sensor positioned adjacent to the sponge for monitoring oxygenation levels of tissue adjacent to the sponge. The dressing system may further include a tube coupled to the sponge for removing fluid from the sponge. The dressing system comprises: a sponge; and a tensioning system coupled to the sponge. The tensioning system further comprises a central longitudinal member coupled to the sponge; and at least one tensioning member coupled to the central longitudinal member. A sequential compression system comprises: an envelope sleeve dressing; and a bladder that is both expandable and retractable. A tissue filler system is also described and includes a plurality of tubes; wherein each of the plurality of tubes further comprises apertures; and a pump coupled to at least one of the tubes which obviates the need for any sponge or wound screen.

Abstract: An electrical breast pump may include a permanently unobstructed continuous passageway across the diaphragm and a rolling diaphragm that is movable between a vent orientation and a vacuum orientation, or a vent piston configured to actuate a closure between a vent orientation and a vacuum orientation so that a pressure chamber is selectively in direct communication with atmospheric pressure.

Abstract: A container for collecting, storing and dispensing fluid, as in enteral feeding and/or medication deliver to neonatal infants. The container includes a hollow tube with a body, a first end, a second end, and an outer diameter. The hollow tube is configured to receive a movable plunger that advances and retracts therein to define a variable contained volume. The container also includes a sealing head assembly removably mounted at an end of the hollow tube. The sealing head assembly has a diameter or outside dimension that is substantially similar or identical to a corresponding outside diameter or dimension of the hollow tube, so that the container lies flat within the receiver of an enteral feeding pump.

Abstract: Systems and methods are provided for optimizing hemodynamics within a patient's heart, e.g., to improve the patient's exercise capacity. In one embodiment, a system is configured to be implanted in a patient's body to monitor and/or treat the patient that includes at least one sensor configured to provide sensor data that corresponds to a blood pressure within or near the patient's heart; at least one adjustable component designed to cause blood to flow in a direction opposite to the normal direction (regurgitation) within the patient's heart; and a controller configured for adjusting the function of the at least one adjustable component based at least in part on sensor data from the at least one sensor.

Abstract: A biomimetic actuation device includes a flexible substrate, conformable for disposition about an object, defining an apex and a base, bearing at least one soft actuator configured to change state from a first state to a second state upon introduction of a pressurized fluid to an internal volume of the at least one soft actuator.

Abstract: A blood pump can include a pump housing, an impeller, and a hub. The pump housing can be configured to move blood from an inlet to an outlet thereof. The impeller can be housed in the pump housing, have a plurality of blades joined by a central ring, and be radially supported at the central ring by a bearing. The hub can transmit torque to the impeller using a radial magnetic coupling.

Abstract: A dialysis machine comprising: a first sensor for detecting motion of a patient; a second sensor for detecting a health condition of the patient; a processing module for: controlling dialysis functions of a dialysis treatment; receiving information related to a status of the dialysis treatment in which toxins are removed from blood of the patient; receiving, from the first sensor, information related to the motion of the patient; receiving, from the second sensor, information related to the health condition of the patient; and identifying an emergency condition based at least in part on the information related to the motion of the patient, the information related to the health condition of the patient, and the information related to the status of the dialysis treatment; and a transceiver for: in response to identifying an emergency condition, sending a notification that includes patient information to one or more remote entities.

Abstract: The example systems, apparatus and methods use a local perfusion extracorporeal circuit (LPEC) for perfusing a local target region of a body, with a systemic perfusion extracorporeal circuit (SPEC) coupled to the core region of the vasculature using a peripheral placed loop to the body, and a control procedure to cause the local target region of the body to be at a specified pattern of temperature values that are different than the temperature of the core of the body.

Abstract: A vascular device for reducing blood flow in a first vessel or a first graft to enable increased blood flow in a second vessel or second graft. The vascular device includes a support structure having a proximal portion, a distal portion and an intermediate portion, the support structure movable from a reduced profile insertion position to an expanded placement position. A covering material is supported by the structure, the intermediate portion in the expanded position having a transverse dimension less than a transverse dimension of the proximal and distal portions to restrict blood flow through the device and thereby increase blood flow to the second vessel or second graft. A method or reducing blood flow in one vessel or graft and increasing blood flow in another vessel or graft is also disclosed.

Abstract: A pump with a controller for adjusting head pressure using a pressure boost is provided. The pressure boost may be dynamically adjusted during a surgical procedure based on the device being used and inflow and/or outflow settings.

Abstract: Adjustable volume syringes, and systems and methods for using the same, are disclosed. An adjustable volume syringe may include a delivery syringe, a reservoir syringe located at least in part within the delivery syringe, and a reservoir plunger located at least in part within the reservoir syringe. The delivery syringe may be configured to contain a first amount of a fluid and the reservoir syringe may be configured to contain a second amount of the fluid. An administration amount of the fluid may be determined at or prior to an administration time, and the amount of fluid in the delivery syringe may be adjusted to equal the administration amount by adding fluid from the reservoir syringe to the delivery syringe or by withdrawing fluid from the delivery syringe to into the reservoir syringe. The administration amount of fluid may be dispensed to a patient at the administration time.

Abstract: An actuator comprises: a cavity containing a working medium (B) that reversibly expands as it undergoes a phase change from a solid to a liquid state; a diaphragm disposed adjacent the cavity such that expansion and contraction of the expandable working medium (B) causes the diaphragm to deflect, and a semiconductor element (A) disposed in the cavity. The semiconductor element (A) is operable in a first mode to heat the working medium (B) to cause it to undergo the phase change into the liquid state, and is operable in a second mode to measure the temperature at the semiconductor element (A). The corresponding actuation method is also disclosed.

Abstract: Devices and methods for delivering a therapeutic substance to a patient are provided. Embodiments include infusion sets that include an active agent. Also provided are systems and kits.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary infusion device includes a motor operable to deliver fluid to a body of a user, a first control module, and a second control module. The first control module and the second control module are coupled to one another. The first control module enables input power for the motor in accordance with a handshaking sequence of communications between the first control module and the second control module and provides a dosage command to the second control module, with the second control module operating the motor using the input power based on the dosage command in accordance with the handshaking sequence of communications.

Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary infusion device includes a motor operable to deliver fluid to a body of a user, a first control module to enable input power for the motor and provide a dosage command for operating the motor, and a second control module coupled to the first control module to receive the dosage command and operate the motor using at least a portion of the input power based at least in part on the dosage command. One of the first control module and the second control module detects an anomalous condition, and in response, disables the input power to the motor, stores diagnostic information for the anomalous condition in its internal memory, and automatically resets thereafter.

Abstract: Some embodiments of an infusion pump system include a controller device that is configured to removably attach to a pump device in a manner that provides a secure fitting, an overall compact size, and a reliable electrical connection. In particular embodiments, the controller device can be secured to the pump device in a generally side-by-side arrangement. The compact size can enhance the discreteness and portability of the infusion pump system.

Abstract: An intravenous line organizer for organizing a plurality of intravenous lines, each being interconnected with a medicament pump is disclosed. A plurality of holders is defined by an elongated tubular wall defining an axis, with adjacent of the tubular walls having parallel axis and being interconnected by a joining member. Each of the tubular walls defines an entry way for receiving an intravenous line used for delivering medicament to a patient. The entry way includes mating appendages for retaining the intravenous line within the holder.

Abstract: An infusion pump includes a pumping mechanism having at least one sensor and a pump motor and a pump control subsystem configured to control operation of the pumping mechanism, the pump control subsystem including a processor, a memory, and a startup module configured to drive the pump motor at a first rate, receive input from the at least one sensor, and drive the pump motor at a second rate based on the input received from the at least one sensor. Startup algorithms command an infusion pump to reach a targeted delivery rate or steady state in minimal time without requiring priming of the pump line or otherwise engaging in known methods of pump startup analysis.

Abstract: A dosing unit for an infusion pump device is disclosed having a piston pump with a pump cylinder and a plunger arranged within said cylinder, coaxially arranged along a longitudinal axis. The plunger has a shaft with a thread and the cylinder has a threaded sleeve part with a thread. The two threads engaging with each other in such a way that a rotational movement of the plunger around the longitudinal axis results in an additional linear displacement of the plunger along said longitudinal axis. A separate bias force element biases the two threads in regard to each other along the longitudinal axis, such that the threaded engagement of inner thread and outer thread is free of play independent of a direction of a rotational movement and linear displacement of the plunger in regard to the cylinder.

Abstract: Flow control devices and methods using the flow control devices are provided. In a general embodiment, a cassette includes a housing having a constrictor, a tube attached to the housing and positioned through the constrictor, and a ball positioned inside the tube. The constrictor can be constructed and arranged to prevent the ball from moving through the tube at the location proximate the constrictor. The ball can prevent fluid flow in one position and be dislodged to allow fluid flow when the cassette is positioned inside a pumping device. As a result, the cassette is designed to prevent free flow of fluid when an enteral feeding tube set is not installed in a pumping device.

Abstract: Some embodiments of an infusion pump system may be configured to detect when at least one component of the pump system is exposed to an impact above a threshold level. In particular embodiments, the infusion pump system can be equipped with a drive system detection system configured to detect when one or more components of the drive system are damaged or inoperable.

Abstract: A microfluidic device (100) is disclosed. The device comprises a triboelectric sensor (102); an elastically deformable pump (104) arranged to transfer fluid to at least one fluid outlet (108) and triboelectrically activate the sensor; and first and second check valves (106a, 106b) respectively arranged at the inlet and outlet of the pump to control fluid transfer in and out of the pump. When the pump is actuated in conjunction with the check valves to transfer a volume of fluid, at least a portion of the sensor is triboelectrically activated according to an amount of deformation of the pump to generate a corresponding output voltage signal for enabling the volume of fluid transferred by the deformed pump to be determined. A corresponding method of using the device is also disclosed.

Abstract: A pump set for use with a pumping apparatus having a rotor with a plurality of rollers mounted on the rotor rotatable about an axis of rotation is disclosed. The pump set comprises a cassette body comprising a stator member with a fixed portion secured to the cassette body, a second portion opposite the fixed portion, a reaction surface and a second surface opposite the reaction surface, the reaction surface defined between the fixed portion and the second portion, and a tube secured to the cassette body, at least a portion of the tube is disposed against the reaction surface.

Abstract: A pump system for pain management may receive input related to a patient's real-time pain to provide automatic adjustments of pain medication bolus delivery based on deduced patient pain. The pump may also collect pain management information during the delivery of pain medication to provide data for improved pain management protocols.

Abstract: A disposable electronically controlled infusion pump system includes at least one disposable infusion container and at least one disposable electronically controlled medication pumping system. The at least one disposable infusion container is configured to contain infusion fluid. The at least one disposable electronically controlled medication pumping system is fluidly connected to the at least one disposable infusion container. The disposable electronically controlled medication pumping system includes an infusion channel, a disposable electronically controlled micropump, and valves, but may further include a microprocessor, a memory, a battery or power receiver configured to wirelessly receive power, a wireless communication device, and other components. The memory is in electronic communication with the microprocessor. The wireless communication device is configured to receive a wireless signal which wirelessly controls the disposable electronically controlled medication pumping system.

Abstract: An intrathecal delivery system for a pharmaceutical includes a reservoir containing a volume of the pharmaceutical agent, and a pump configured to deliver a portion of the pharmaceutical agent contained in the reservoir. A controller is configured to receive biological cycle information pertaining to a biological cycle (e.g., cardiac cycle), and configured, based on the received biological cycle information, to control the pump to deliver the pharmaceutical agent into a patient's intrathecal space as a high-speed bolus at a time corresponding to a time determined based on Processing the biological cycle information. The high-speed bolus may be delivered at a rate of 10-100 ?L per second. The timing of such delivery corresponds to a time within the biological cycle when cerebrospinal fluid flow is optimal for intrathecal delivery of the pharmaceutical agent. Conditions for which treatment is enhanced by the intrathecal delivery system include refractory hypertension, spasticity and chronic pain management.

Abstract: Disclosed is a syringe for corium regeneration. The syringe includes a cylinder formed as a thin tube having an inner diameter of 2-7 mm such that a liquid can be separated and stacked over a gas inside the cylinder; an inflow check valve provided on one side of the lower end of the cylinder such that a gas, which is supplied from the outside, can flow into the cylinder; and a needle coupled to the lower end of the cylinder, the upper end of the needle being positioned between a point which is 2 mm below the portion of connection of the inflow check valve and a point which is 5 mm above the portion of connection of the inflow check valve.

Abstract: The present disclosure relates to systems and methods for injecting multiple fluids into the vasculature of a patient using a minimal number of valve and stopcock manipulations. In particular, the present disclosure relates to a fluid injection system that combines a contrast source valve and a manifold in-line to a manual or automated syringe assembly for alternately injecting contrast and saline solutions into the vasculature of a patient.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (M), the housing having a distal end (D) and a proximal end (P) with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end (P), operate the syringe to supply the dose of medicament (M), and retract the syringe with the needle after delivering the medicament (M). An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: A method of delivering high pressure medication injections, the method comprising storing a medicament in a cartridge, engaging a lever gear in a lever assembly to a rack, rotating a lever arm in said lever assembly that is connected to said lever gear, moving said rack to move a stopper through said cartridge upon rotation of said lever arm, expelling a medicament dose from said cartridge via movement of said stopper, and injecting said medicament dose through a needle that communicates with said cartridge.

Abstract: Methods of operating needle-free injection device having an outer housing and an inner housing is disclosed. The inner housing is configured to receive a needle-free syringe in one end. In addition, the inner housing is movable within the outer housing between a syringe loading position and a firing position. The device may include an activation button operatively associated with the inner and outer housings and a housing lock engaged by the activation button to prohibit movement of the inner housing from the syringe loading position to the firing position when the activation button is activated with the inner housing in the syringe loading position.

Abstract: A needle-free injection device suitable for delivering a therapeutic substance into the intradermal space of a patient. The needle-free injection device includes a main spring which can be compressed using one or more handles attached to the device to place the needle-free injection device into an armed configuration. Device embodiments may optionally include an injector tube and associated apparatus which may be moved relative to other device structures when the injector is pressed against the skin of a patient with sufficient force. The disclosed operational switches and release mechanisms cooperate to prevent injection unless the device is properly positioned for an injection. Needle-free injection systems and methods of operating a needle-free injection device are also disclosed.

Abstract: A stable biopolymer-based emulsion lubricant including Agar is provided to reduce the friction between a syringe barrel plunger and the interior surface of the syringe barrel. According to exemplary embodiments the emulsion has a friction of less than 4N, the emulsion is temperature stable in a range of 4-23 degrees Celsius and the emulsion is stable for a period of at least 60 days.

Abstract: A cartridge interface assembly drives a stopper in a drug reservoir or a drug delivery device. An anti-rotational guide optionally moves along an axis of a cavity of the reservoir. The anti-rotational guide is optionally slidably anti-rotationally coupled to a housing of the drug delivery device. A telescoping plunger driver may include a proximal shaft and distal shaft that telescope by relative rotation. The distal shaft is optionally slidably anti-rotationally coupled to the anti-rotational guide. The shafts are optionally oriented along said axis. In some embodiments, rotating the proximal shaft with respect to the anti-rotational guide moves the guide along said axis with respect to the housing and moves the distal shaft along the axis with respect to the anti-rotational guide.

Abstract: An injection device includes a housing, a dosing member held so as to be rotatable and fixed in the housing and an injection sleeve held so as to be rotationally fixed in relation to the housing and displaceable therein. A latching unit of the injection device is configured to act between two components thereof which, during setting of an amount of injection fluid to be dispensed, move relative to one another. A set amount of injection fluid is unequivocally assigned to each relative position of the two components.

Abstract: Certain configurations are directed to a syringe configured to provide tactile feedback and that permits injection of a plurality of individual metered volumes. In some embodiments, the syringe can be used to inject a metered volume of a botulinum toxin at each of a plurality of separate sites of a bladder wall to treat overactive bladder.

Abstract: A syringe for the injection of an active substance and for the secondary injection of a medium, the syringe having a cylindrical syringe body with a limiting wall provided in the distal region, which transitions into a neck, two mechanically connected plungers that are axially displaceable in the syringe body, and a first actuating element for mutual displacement of the plungers, wherein, prior to the injection of the active substance, the distal plunger and the limiting wall delimit a first volume that is filled with the active substance, and mutually facing inner surfaces of the plungers delimit a second volume that is filled with the medium, wherein the plungers are displaced as a mechanically coupled unit by the application of force of the first actuating element in the direction of the limiting wall until the distal plunger comes to rest against the limiting wall or a stop.

Abstract: The invention resides in a hand-held medicament delivery device which comprises a housing containing a first electrical circuit and a battery, a medicament delivery mechanism, and a protective cap releasably securable to the housing. The housing also includes a contactless switch and the cap a switch actuator. The switch is operable between an on state in which the first electrical circuit is connected to the battery and an off state in which the first electrical circuit is disconnected from the battery. The invention also resides in a method of controlling power in a hand held medicament delivery device comprising the steps of actuating a contactless switch in the housing by an actuator in a housing cap when the switch and actuator are in proximity, the actuation of the switch signalling to a microprocessor that the cap is on the housing, detecting the status of the device by the microprocessor, and only if the microprocessor determines the device is inactive, powering down the device.

Abstract: A needle covering system for a needle of a syringe. A boot of the system defines a contaminant-proof pocket for the needle. A sealing ring portion of the boot forms a seal with a support portion of the syringe. A body of the boot is collapsible to allow movement of a needle pierceable end portion of the boot toward the sealing ring portion for a tip of the needle to pass through the boot end portion for an injection. A securement collar of the system presses the sealing ring against the support portion of the syringe and is a remnant portion of a protective shell.