Abstract: Embodiments of systems and methods for characterizing multiphase flow (MPF) of fluid and enhancing measuring and monitoring of a full range of water cut in a portion of a pipe for oil-related operations are provided. An embodiment of a system can include a flow director to direct the MPF between paired wide-band near-infrared (NIR) emitters and detectors electrically coupled to signal conditioning, processing, and characterizing modules to determine absorption and scattering of MPF and define and display MPF characteristics for measuring and monitoring in oil-related operations.

Abstract: A method is for simultaneously analyzing nutritional component content in a plurality of various foods or agricultural sources having different ingredients and forms, that is, different physicochemical properties and compositions distributed in Korea by near-infrared reflectance spectroscopy. In particular, a method is for rapidly and accurately measuring nutritional component content in a plurality of various foods or agricultural sources having different ingredients and forms, that is, different physicochemical properties and compositions distributed in Korea by near-infrared reflectance spectroscopy.

Abstract: An inspection device (40) is configured to be provided with; white LED illuminators (41a1, 41a2, 41b1, 41b2); IR-LED illuminators (43a, 43b); visible range color cameras (42A, 42B); an IR monochrome camera (44) which is provided at a position outside the fields of view of the cameras (42A, 42B); support frames (49a, 49b) which support the illuminators (41a1, 41a2, 41b1, 41b2, 43a, 43b); an IR filter (45) which causes only infrared rays to be incident on the camera (44); and a control unit (46) which, according to visible light incident on the cameras (42A, 42B), determines whether a pattern portion printed on paper (W) by ordinary ink is appropriate or not, and according to the infrared rays incident on the camera (44), determines whether a portion in which a “security thread” is processed and a portion in which an “OVD” is processed of the paper (W) are appropriate or not.

Abstract: Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.

Abstract: A differential refractometer including a measurement section for measuring the diffractive index difference between a sample cell and a reference cell by radiating light on a measurement cell and detecting light which has sequentially passed through the sample cell and the reference cell includes a mobile phase supply section for delivering a mobile phase in a sample introduction channel that is connected to the sample cell. The mobile phase supply section includes a mobile phase container for containing the mobile phase. The inside of the mobile phase container is continuously stirred by a stirring mechanism, and the composition of the mobile phase inside the mobile phase container is made uniform.

Abstract: There is provided an optical characteristic measurement system that can be set up in a relatively short time and can increase a detection sensitivity. The optical characteristic measurement system includes a first measurement apparatus. The first measurement apparatus includes: a first detection element arranged in a housing; a first cooling unit at least partially joined to the first detection element that cools the detection element; and a suppression mechanism that suppresses temperature variations occurring around the detection element in the housing.

Abstract: Provided is a method for inhibiting self-absorption effect of a LIBS, comprising ablating a to-be-measured sample via a pulse laser thereby generating plasma, and selectively stimulating the plasma using a wavelength-tunable laser beam enabling transition of particles in a ground-state in the plasma to high energy state as stimulated absorption, thereby improving a stimulated absorption transition efficiency of the particles in a ground-state, and preventing plasma spectrum from being influenced by self-absorption effect. The invention is capable of eliminating the self-absorption effect without introducing external interference, obtaining original characteristics of emission spectrum from the center of the plasma, and essentially inhibiting and finally eliminating the self-absorption effect of laser plasma by making use of intrinsic physical property of plasma.

Abstract: A system can include an exchangeable mounting structure having a visual marking or coloring and at least one physically associated sample introduction system component having an indicating mark or color matching the visual marking or coloring of the exchangeable mounting structure. The visual marking or colored corresponds to a sample analysis configuration for analyzing a particular sample type at an analytical instrument.

Abstract: A method of spectroscopic analysis of a diamond for determining whether the diamond has been artificially treated to change its colour may include: generating light emission from a diamond upon optical excitation at a wavelength equal to or smaller than 680 nm; optically producing a dispersed light emission; detecting the dispersed light emission across a collected spectral region including emission wavelengths of from 670 nm to 735 nm; processing the output signals to produce a spectral intensity distribution as a function of emission wavelengths; analysing the spectral intensity distribution to determine the presence or absence of a spectral pattern including either an intensity peak at 681 nm or a combination of intensity peaks at respective wavelengths 705 nm and 725 nm; if a spectral pattern is present, establishing that the diamond has been treated; and if a spectral pattern is absent, establishing that the diamond has not been treated.

Abstract: Semiconductor processing tool smart window kits, and smart windows for semiconductor processing tools and semiconductor processing tool doors, are discussed herein. Some smart windows may include a smart film with an active area that is electronically controllable between an opaque state and a transparent state, and that may be configured to prevent light from passing through the smart window and entering into a semiconductor processing tool and/or semiconductor processing chamber when in the opaque state. Additional components, configurations, and/or systems of some kits and smart windows are further discussed herein, which may include an electrical contact cover that may be configured to electrically connect the smart film to a power source and a smart film controller that may be configured to cause a smart film to transition between the opaque and transparent states.

Abstract: According to an embodiment of the invention there may be provided a system for inspecting an object, the system may include a traveling lens acousto-optic device that is configured to generate a sequence of traveling lenses that propagate through an active region of the traveling lens acousto-optic device; an illumination unit that that is configured to illuminate the sequence of traveling lenses to provide a sequence of input beams; a first beam splitter that is configured to split the sequence of input beams to an intermediate array of intermediate beams, the intermediate array comprises multiple sequences of intermediate beams, the sequences of intermediate beams are spaced apart from each other; a masking unit that is configured to mask first beams of the intermediate array and unmask output beams of the intermediate array in an alternating manner; multiple detectors; and an objective lens that is configured to receive the output beams, direct the output beams towards multiple areas of the object, receive

Abstract: An inspection system for inspection a surface of a substrate, the inspection system may include an interface for holding the substrate; a movement mechanism for moving the interface, thereby moving the substrate between different positions; a bright field light source that is configured to illuminate different bright field illuminated parts of the surface of the substrate when the substrate is positioned at the different positions; at least one dark field light source that is configured to illuminate different dark field illuminated parts of the surface of the substrate when the substrate is positioned at the different positions; and a camera that is configured to: (a) generate bright field detection signals in response to light that is detected by the camera as a result of the illumination of the different bright field illuminated parts; and (b) generate dark field detection signals in response to light that is detected by the camera as a result of the illumination of the different dark field illuminated par

Abstract: Methods including optically interacting electromagnetic radiation with a flowing powder composition and a first integrated computation element (“ICE”), the first ICE being configured to detect a contaminant in the powder composition; receiving the electromagnetic radiation with a detector; and generating an output signal corresponding to a characteristic of the contaminant in the powder composition.

Abstract: A surface inspection system, as well as related components and methods, are provided. The surface inspection system includes a beam source subsystem, a beam scanning subsystem, a workpiece movement subsystem, an optical collection and detection subsystem, and a processing subsystem. The optical collection and detection system features, in the front quartersphere, a light channel assembly for collecting light reflected from the surface of the workpiece, and a front collector and wing collectors for collecting light scattered from the surface, to greatly improve the measurement capabilities of the system. The light channel assembly has a switchable edge exclusion mask and a reflected light detection system for improved detection of the reflected light.

Abstract: Charged and neutral particles, photons (13), photonic optics, detectors (15) and sensor arrays are used for application to molecular imaging, communication with biological organisms and monitoring and learning biological activity inside living organisms. The living organisms include among others living tissue, biological organs, cells (10), eukaryotes, prokaryotes, viruses and phages. Molecular imaging can be an effective new tool to understand the mechanisms of life and communicate, modify and control it. Techniques, methods and devices are described to achieve these aims. The probes used in molecular imaging described above will include the full spectrum of photons; charged and uncharged particles (13); chemicals; and biological probes.

Abstract: A method includes obtaining spectral computed tomography (CT) information via an acquisition unit having an X-ray source and a CT detector. The method also includes, generating, with one or more processing units, using at least one image transform, a first basis image and a second basis image using the spectral CT information. Further, the method includes performing, with the one or more processing units, guided processing on the second basis image using the first basis image as a guide to provide a modified second basis image. Also, the method includes performing at least one inverse image transform using the first basis image and the modified second basis image to generate at least one modified image.

Abstract: A gamma densitometer window is provided along with a method of fabrication thereof. The window comprises a plate of non-metallic, preferably gamma transparent, material having a first face and a second face opposing one another and having an outer edge defined therebetween. The window further comprises a metallic frame member fitted around the outer edge of the plate and adapted to pre-load the plate with a compressive stress that is sufficiently high such that the sum of the compressive stress, tensile stress and shear stress components generated in the plate under high-pressure conditions is always compressive. The method of fabrication shrink fitting the metallic frame member around the outer edge of the plate at a shrink-fit temperature such that the metallic frame member applies a compressive stress to the plate at any temperature below the shrink-fit temperature.

Abstract: A micro beam generation unit capable of simultaneously capturing anisotropic images in a high signal-to-background ratio with a compact configuration and an X-ray small-angle scattering apparatus are provided. A micro beam generation unit 110 generates X-rays having a micro spot size, with which a sample is irradiated, in order to detect diffracted X-rays by a one-dimensional detector or a two-dimensional detector. The micro beam generation unit 110 includes a slit 115 that is provided on an X-ray optical path and reshapes X-rays into parallel beams, and two channel-cut monochromator crystals 117 and 118 that are arranged in arrangement of (+, ?, ?, +) and remove parasitic scattering of parallel beams reshaped by the slit. Accordingly, it is possible to simultaneously obtain anisotropic images in a high signal-to-background ratio with a compact configuration.

Abstract: A measurement system for a gamma activation analysis is configured to be utilized in a determination of concentration of at least one material under focus in a sample. The system includes a radiation source for providing a radiation beam, an irradiation device for storing at least temporarily the sample under irradiation, a radiation detector for measuring emitted radiation from the irradiated sample, a computing unit for determining the concentration of at least one material under focus in the sample, wherein the measurement system further including a transport channel, which transport channel provides a first delivery channel portion from a sample material input of the system to the irradiation device and a second delivery channel portion from the irradiation device to the radiation detector for measurement wherein the sample material is configured to be delivered in the first and the second channel portion.

Abstract: The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium.

Abstract: The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells.

Abstract: A transfer apparatus includes a supporting member, a free electron excitation device and a detection device; the free electrons excitation device is configured to excite semiconductor material of an object to be transferred to generate free electrons, and the detection device is configured to detect whether material of a surface of the transferred object in contact with the support surface of the supporting member is conductive under excitation by the free electron excitation device. A laser annealing apparatus comprising the transfer apparatus is further provided.

Abstract: The present disclosure relates to methods and devices for gas sensing. A gas sensor includes a sensing element comprising at least an ionic liquid. The gas sensor also includes a set of electrodes for polarizing the sensing element and an electric power source for powering the set of electrodes, thus generating an impedimetric response signal from the sensing element. The gas sensor additionally includes readout circuitry for separately analyzing resistive and capacitive components in the impedimetric response signal. A method includes exposing a gas sensor to a gas. The gas sensor includes a sensing element including at least an ionic liquid. The method also includes polarizing the sensing element with an electrical signal at a first frequency, measuring an impedimetric response signal of the sensing element, separating the signal into resistive and capacitive components, and determining the composition of the gas based at least on the resistive and capacitive components.

Abstract: One example discloses a breach sensor, comprising: a substrate including an integrated circuit; a passivation layer coupled to the substrate; a breach sensing element coupled to the circuit; wherein the breach sensing element is on a first side of the passivation layer and the substrate is on a second side of the passivation layer; a barrier configured to separate the breach sensing element from an ambient environment; wherein the breach sensing element is responsive to barrier damage.

Abstract: A method of detecting a defect in a weld joining a first surface of a polyethylene-based material and a second surface of a polyethylene-based material, said method comprising the steps of: positioning a first electrode and a second electrode in proximity to the weld, so that at least one electric field line passes through said weld when a potential difference is applied between said first and second electrodes, measuring an electrical capacitance at a measurement frequency between said first electrode and said second electrode, the measurement frequency being higher than 65 MHz and lower than 1 GHz in order to compare the measured electrical capacitance to a reference value.

Abstract: A membrane electrode includes a novel sensor combining a filtering function of a membrane and a signal measuring ability of an electrode. A target material may be measured by filtration through the membrane. A small amount of target materials may be detected with high sensitivity using an amplified electrical signal by increasing electrical conductivity by reducing metal ions on the membrane, and thus the target material may be subject to quantitative analysis. In addition, only a target material selectively binding to a receptor may be filtrated by passing a sample through the membrane after a receptor material is fixed to the electrode, and thus may be used to detect an electrical signal. In addition, the sensor may measure a signal in various methods such as electrical conductivity, impedance, etc.

Abstract: A gas sensor includes a housing, an insulator, an inner cover, and an outer cover. An inner peripheral hole of the housing includes a rear end side hole and a front end side hole portion and a rear end side hole portion. A step portion which is formed in a slant shape is provided at a boundary between the front end side hole portion and the rear end side hole portion. The inner cover has a large-diameter portion which faces the step portion. The insulator has a flange which holds the large-diameter portion between itself and the step portion. A burr is formed on the surface of the large-diameter portion. The burr faces the surface of the step portion. This avoids inclination of the cover relative to the inner peripheral hole of the housing and obviates the risk of damage to or breakage of a device body.

Abstract: An exhaust gas sensor includes a sensor element having a plurality of cells, and a heater heating the sensor element. A heater control device for the exhaust gas sensor includes a heater power control unit that performs an impedance control, in which an energization of the heater is controlled by detecting an impedance of one cell to be measured, of the plurality of cells, such that the impedance of the one cell agrees with a target impedance. The heater power control unit, in the impedance control, estimates a temperature of the other cell other than the one cell based on at least one parameter of an energization condition of the heater and an operating condition of the internal-combustion engine, and corrects the target impedance so that the temperature of the other cell becomes lower than or equal to a permissible upper limit temperature.

Abstract: Ion sensor based on differential measurement comprising an ISFTET-REFET pair wherein the REFET is defined by a structure composed of an ISFET covered by a microreservoir where an internal reference solution is contained. The sensor comprises a first and a second ion-selective field effect transistor, an electrode, a substrate on the surface whereof are integrated the two transistors, connection tracks and the electrode and a structure adhered on the first ion-selective field effect transistor which creates a microreservoir on the gate of said first transistor, with the microreservoir having a microchannel which connects the microreservoir with the exterior and the microreservoir being filled with the reference solution.

Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

Abstract: There is provided a method for distributing power in an electrophoresis system from a power supply to each channel of an interfaced cassette connected to a pedestal located on the electrophoresis system, the method comprising: receiving a power signal from the power supply at the pedestal; receiving at least one externally generated control signal; and, modulating the power signal at a processor electrically coupled to the pedestal in dependence upon the control signal to generate a modulated power signal defined for each said cassette channel of the pedestal.

Abstract: This invention concerns a device and a method for inspecting aluminum cables with a steel core (ASCRs), installed in energized electrical energy lines, which use the ECT (Eddy Current Testing) technique for evaluating the remaining thickness of the zinc layer which covers the steel wires of the cables inspected, where the readings of the tension of the detection solenoid and the current of the excitation solenoid are taken as the current of the conductor reaches zero, the electrical parameters of the conductor are corrected for the average temperature during the inspection and the signal from the detection solenoid is filtered through a hybrid circuit which is designed to increase the sensitivity of the measurement.

Abstract: A lifting device, which is configured to lift or drop at least one load bearing mechanism. The lifting device includes a power driving mechanism and multiple lifting mechanisms connecting to the power driving mechanism. The multiple lifting mechanisms march the load bearing mechanism at least from a first height location to a second height location in a rolling manner under a function of a driving force provided by the power driving mechanism. An embodiment of the present invention further discloses an ultrasonic inspection system using the lifting device.

Abstract: A method including ultrasonically scanning a structure with a laser ultrasound testing system where the structure is provided with an array of nanoscopic structures, the nanoscopic structures having a predetermined directional orientation, the nanoscopic structures disposed on a scanned surface of the structure, and determining if the structure meets a predetermined threshold. Aspects of this invention apply certain high emissivity coatings to structures for the purpose of significant improvement laser ultrasound inspection of those structures. The nanotechnology-based material in the coatings rapidly draws heat away, for maximum laser energy absorption while preventing surface heat damage to the composite surface from the laser beam.

Abstract: A chromatographic apparatus includes two chromatographic columns configured to perform chromatography. The apparatus further includes a primary valve disposed upstream of the first chromatographic column and the second chromatographic column. The primary valve selectively switches between a first position in which the pump is in fluid communication with a first path that includes the first chromatographic column and a second position in which the pump is in fluid communication with a second path that includes the second chromatographic column. The apparatus also includes a first and a second sample injection port associated with said first and second columns, respectively, and at least one detector. The apparatus is configured such that flow from the column in the selected path goes to said at least one detector without passing through the other column.

Abstract: A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (GC-MS) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the GC-MS system, at a location between a high vacuum end of a transfer line and a mass analyzer of the GC-MS system. Additionally, the column-sealing tool includes a sealing element that is actuatable between a non-sealing position and a sealing position. During use the sealing element forms a secondary vacuum seal with the first end of the transfer line when the column-sealing tool is inserted into the GC-MS system and when the sealing element is in the sealing position.

Abstract: Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage-form. The high-accuracy evaluating is realized by selecting with high accuracy one of reference fingerprints to which peaks of a target fingerprint prepared from the chromatogram are assigned.

Abstract: A gas sensor having a heater layer; and a gas detector that is heated by the heater layer to detect a measurement target gas. The gas detector has a gas sensing layer, a diffusion layer that covers a surface of the gas sensing layer, and an absorption layer that covers a surface of the diffusion layer. The absorption layer has greater absorption of the measurement target gas than the diffusion layer, and the diffusion layer has greater diffusion of the measurement target gas than the absorption layer.

Abstract: A method comprises: receiving wine evaluations of wines from wine panelists, each wine evaluation including intensity values describing a plurality of wine characteristics for each of a set of wines, each wine evaluation generated by a wine panelist; generating a global intensity value from particular intensity values describing a particular wine characteristic of a particular wine, the particular intensity values being from the wine evaluations; comparing a selected intensity value generated by a selected wine panelist describing the particular wine characteristic for the particular wine against the global intensity value to determine an accuracy deviation; comparing the accuracy deviation against an accuracy deviation threshold to determine whether the selected intensity value is deemed inaccurate based on the comparison; updating the global intensity value for the particular wine characteristic for the particular wine based on the accuracy determination; and storing the updated global intensity value in a

Abstract: The disclosure includes an apparatus for determining a measured value in a liquid medium, comprising at least a light transmitter, at least one light receiver assigned to the transmitter, a measuring chamber that can be filled with the medium, wherein an optical path runs through the measuring chamber from the transmitter to the receiver. The apparatus includes a dosing apparatus for dosing at least one reagent and/or the medium, and for inserting the dosed reagent and/or the medium into the measuring chamber. The dosing apparatus is designed as a tube, and the tube includes at least a first control point, wherein the volume in the tube from a starting point to a first control point defines the amount of reagent or medium to be inserted into the measuring chamber. The disclosure further includes the use of the apparatus and a method for dosing the reagent.

Abstract: The present invention relates to a method for detecting cadmium capable of easily, rapidly, and simply detecting cadmium quantitatively and qualitatively by sequentially adding albumin and a reducing agent to a sample, the albumin and the reducing agent inducing synthesis of a cadmium nanocluster capable of measuring a change in fluorescence intensity. In addition, the albumin and the reducing agent used for the method for detecting cadmium have excellent sensitivity even though they are low-cost, such that concentration of the cadmium present in the sample is capable of being directly measured.

Abstract: A system, comprising at least one source for irradiating electromagnetic radiation into a sample fluid and a reference fluid resulting in a change in a temperature of the sample fluid and a change in a temperature of the reference fluid, and a processing subsystem that monitors and determines a concentration of a gas of interest dissolved in the sample fluid based upon a difference between the change in the temperature of the sample fluid and the change in the temperature of the reference fluid, wherein the reference fluid does not contain the gas of interest, and the electromagnetic radiation has a wavelength range corresponding to a spectral absorption range of the gas of interest.

Abstract: An apparatus for analyzing a multiphase fluid in a pipeline. The apparatus comprises: i) an elongated shaft adapted to be inserted into the pipeline, the elongated shaft comprising a measurement electronics section and an extension section; ii) a housing coupled to the elongated shaft and adapted to be positioned outside the pipeline when the elongated shaft is inserted into the pipeline; and iii) a ground cage coupled to the elongated shaft, the ground cage comprising a sensor coupled to the measurement electronics section. The ground cage comprises a tube having perforations therein to permit multiphase fluid to flow within the ground cage. The sensor comprises a ceramic rod and an antenna within the ceramic rod.

Abstract: An unseen benefit indicator kit containing a vitamin, mineral, supplement product, a first biomarker test, and a final biomarker test. The kit provides an unseen benefit indicator that allows users to see health benefits while taking the vitamin, mineral, supplement product.

Abstract: Described are methods and structures associated with live cell analysis apparatus. A live cell analysis apparatus may include at least one data processor that is configured to process a sequence of images of live cells to determine motion of one or more live cells. The motion may be in response to applied electrical stimulations. The apparatus and methods may be used to determine a refractory period for cardiomyocytes from the determined motion.

Abstract: A method for predicting cellular, tissue and clinical radiosensitivity, which is based on the determination and correlation of multiple parameters and cellular and enzymatic criteria.

Abstract: The present invention provides methods to modulate key elements along the DAG signaling pathway as well as a diagnostic assay, device and methods of using the same to diagnose bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods to identify diagnostic markers and drug targets for BD and ADHD. Methods of identifying effective compounds responsible for membrane potentials and excitabilities influencing bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods of identifying an effective compound that modulates the activity of Ca2+/CaM enzyme and compounds involved in changing the K+ gradient across the plasma membrane thereby increasing or decreasing the membrane potential ratio (MPR™) values. The invention provides methods of identifying a compound that modulates the activity of PKC which is an important protein of the DAG signaling pathway.

Abstract: The present invention provides a method for screening a therapeutic and/or prophylactic agent for Alzheimer's disease using at least one index selected from the levels of A? oligomers, BiP, cleaved caspase 4, PRDX4 and ROS in nerve cells or the like whose differentiation has been induced from iPS cells derived from somatic cells of a patient with Alzheimer's disease.

Abstract: This invention provides biosensors, cell models, and methods of their use for monitoring heme, oxygen or ATP. Biosensors can include targeting domains, sensing domains and reporting domains. Biosensors can be introduced into cells reprogrammed to represent experimental or pathologic cells of interest. Model cells expressing the biosensors can be contacted with putative bioactive agents to determine possible activities.

Abstract: The invention relates to a novel biosensor, the metal-insulator transition (MIT) point biosensor, a non-expensive miniaturized device, having a small footprint and high sensitivity, which can measure molecular interactions or the presence of small amounts of molecules without the need for the molecules to be labeled. The sensor comprises a vanadium dioxide (V02) layer located between two metal measuring pads. The introduction of molecules of interest to the sensor surface results in changes in the oxide interface charge density that can be detected by a shift in the metal oxide transition point and differences in the amount of current passing through the oxide. The MIT biosensor is useful for the detection of charged molecules, including macromolecules, such as proteins or nucleic acids as well as other types of particles, such as cells, bacteria, or viruses.