Patents Issued in January 24, 2017
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Patent number: 9549993Abstract: Disclosed are antibody drug conjugates (ADC) that include highly potent toxic agents with specific antibodies to target tumors. Also disclosed are related antibodies, polypeptides, nucleic acids, host cells, compositions, and uses.Type: GrantFiled: October 2, 2013Date of Patent: January 24, 2017Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, GEORGETOWN UNIVERSITYInventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin, Michael Johnson
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Patent number: 9549994Abstract: Compositions of an inclusion complex of nicardipine or a pharmaceutically acceptable salt thereof and a sulfoalkylated ?-cyclodextrin. The compositions being formulated for parenteral bolus administration to a human subject. The compositions being useful in the treatment of cardiovascular and cerebrovascular disorders.Type: GrantFiled: September 18, 2013Date of Patent: January 24, 2017Assignee: EKR Therapeutics, Inc.Inventors: Supriya Gupta, Yanli Mi, Camellia Zamiri
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Patent number: 9549995Abstract: Novel methods of synthesis of ethylenedicysteine-sugar conjugates and therapeutic and diagnostic applications of such conjugates are disclosed. Methods of synthesizing these conjugates in high purity are also presented as using starting materials such as thiazolidine carboxylic acid. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these conjugates prepared herein, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.Type: GrantFiled: March 26, 2013Date of Patent: January 24, 2017Assignee: Board of Regents, The University of Texas SystemInventors: David J. Yang, Dong-Fang Yu
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Patent number: 9549996Abstract: A silica particle for medical imaging includes a bridged silane fluorescent dye incorporated throughout the particle matrix. Copolymerization of a bridged silane fluorescent dye (e.g., (R?O)3Si—R—Si(OR?)3, where R is a fluorescent organic bridging group, and where R? is a methyl or ethyl group) and a tetralkoxysilane (e.g., Si(OR?)4, where R? is a methyl or ethyl group) generates particles of a predetermined size and shape. This leaves the surface of each particle available for further modification to facilitate dispersion of the particle into different media. Hence, a surface modifier may be subsequently bonded onto the particle surface. In some embodiments, poly(ethylene glycol) is selected as the surface modifier to increase dispersion of the silica particle in an aqueous media. In some embodiments, the particle is porous allowing for an additional functionality (e.g., a secondary imaging material, such as magnetic nanoparticles, and/or a pharmaceutical drug) to be loaded within the pores.Type: GrantFiled: May 5, 2015Date of Patent: January 24, 2017Assignee: International Business Machines CorporationInventors: Dylan J. Boday, Jason T. Wertz
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Patent number: 9549997Abstract: The present invention relates to methods of visualizing cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalized by the cells and thus permits subsequent visualization by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualizing cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualizing cells by virtue of internalization and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.Type: GrantFiled: April 5, 2012Date of Patent: January 24, 2017Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGHInventors: Tashfeen Walton, Mark Bradley, Kev Dhaliwal, Nikolaos Avlonitis, Chris Haslett, Neil McDonald, Manuelle Debunne
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Patent number: 9549998Abstract: A kit for providing a contrast enhancer in a mammal for contrasting during imaging of the mammal comprises functionalized gold nanoparticles configured to be directed to one or more of a target organ, tissue and lesion of the mammal.Type: GrantFiled: June 27, 2008Date of Patent: January 24, 2017Assignee: The Curators of the University of MissouriInventors: Vijaya Kattumuri, Kattesh V. Katti, Evan Boote, Raghuraman Kannan, Stan Casteel, Robert Churchill
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Patent number: 9549999Abstract: The present invention provides a 99mTc-tetrofosmin radiopharmaceutical composition comprising tetrofosmin and a radioprotectant at a particular range of molar ratios. A kit and a multi-dose kit for the preparation of the radiopharmaceutical composition of the invention are also provided, as well as a process for the preparation of multiple unit patient doses of the radiopharmaceutical composition and a unit dose of the radiopharmaceutical composition.Type: GrantFiled: September 19, 2008Date of Patent: January 24, 2017Assignee: GE Healthcare LimitedInventors: Janne Veggeland, Grethe Karin Madsen, Stig Hemsted
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Patent number: 9550000Abstract: The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.Type: GrantFiled: September 7, 2012Date of Patent: January 24, 2017Assignee: Lantheus Medical Imaging, Inc.Inventors: Simon P. Robinson, Ming Yu
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Patent number: 9550001Abstract: The invention provides D02S derivatives conjugated to monosaccharide ligands directly or through a linker and optionally chelated to a metal, wherein the D02S derivatives having the following structure: wherein R1?, R2? are each independently —OH or —O-alkyl; R1 is a hydrogen, a linker, or a ligand; R3 is a linker and/or a ligand; and n is an integer from 1 to 10; the linker is an amino acid, a peptide, an amino alcohol, a polyethylylene glycol, an alkyl, an alkenyl, an alkynyl, an azide, an aromatic compound, a carboxylic acid, or an ester, the alkyl, alkenyl, or alkynyl is optionally substituted with an alkyl, a halogen, a nitro group, a hydroxyl group, an amino group, or a carboxyl group; the ligand is a GLUT1 targeting moiety.Type: GrantFiled: June 20, 2012Date of Patent: January 24, 2017Assignee: RadioMedix Inc.Inventors: Izabela Tworowska, Jennifer Sims-Mourtada, Ebrahim S. Delpassand
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Patent number: 9550002Abstract: The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.Type: GrantFiled: September 30, 2014Date of Patent: January 24, 2017Assignee: CELLECTAR BIOSCIENCES, INC.Inventors: Jamey P. Weichert, Marc Longino, Anatoly Pinchuk
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Patent number: 9550003Abstract: An installation for treating articles by radiation, the installation comprising a structure (1) having an article transport device (10) mounted thereon with a portion housed in a shielded enclosure (2) in the vicinity of at least one radiation emitter (3), the enclosure including a tunnel (40) having internal transverse partitions (51, 52, 53, 54) defining a baffle passage (50) through which there extends a segment of the transport device. The partitions are arranged in such a manner that the baffle passage extends in a plane that is substantially vertical. A packaging installation including such a processing installation.Type: GrantFiled: June 2, 2014Date of Patent: January 24, 2017Assignee: SERAC GROUPInventor: Nicolas Geslot
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Patent number: 9550004Abstract: A solution for generating ultraviolet diffusive radiation is provided. A diffusive ultraviolet radiation illuminator includes at least one ultraviolet radiation source located within a reflective cavity that includes a plurality of surfaces. At least one of the plurality of surfaces can be configured to diffusively reflect at least 70% of the ultraviolet radiation and at least one of the plurality of surfaces can be configured to transmit at least 30% of the ultraviolet radiation and reflect at least 10% of the ultraviolet radiation.Type: GrantFiled: September 5, 2014Date of Patent: January 24, 2017Assignee: Sensor Electronic Technology, Inc.Inventors: Saulius Smetona, Alexander Dobrinsky, Yuri Bilenko, Michael Shur
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Patent number: 9550005Abstract: Embodiments of this disclosure include systems, methods, and kits for sterilizing in vivo catheters using an optical fiber to deliver UV light. In an embodiment, a method for sterilizing a catheter with at least a first lumen, includes inserting a distal end of a fiber optic cable into a fiber insertion port of a catheter connector attached to a hub of the first lumen, flushing the first lumen with fluid from a fluid source, inserting the fiber optic cable into the first lumen until a stopper of the fiber optic cable is adjacent to the fiber insertion port, providing light to the fiber optic cable from a light source after the fiber optic cable is inserted into the first lumen, withdrawing the fiber optic cable from the first lumen while the light is provided, and ceasing to provide light to the fiber optic cable after the fiber optic cable is withdrawn from the first lumen. The disclosure is also applicable to catheters with multiple lumens and to catheters accessed through subcutaneous ports.Type: GrantFiled: April 28, 2015Date of Patent: January 24, 2017Assignee: Ultraviolet Interventions, Inc.Inventors: Roger C Lin, Laurence M Sandell
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Patent number: 9550006Abstract: Embodiments relate generally to systems and methods for treating passenger transportation vehicle cabin surfaces and surrounding air. The methods may use organic LEDs to produce ultraviolet light. Systems may be provided to ensure safety and operation of the air treatment only when passengers and personnel are not present in the cabin.Type: GrantFiled: September 25, 2015Date of Patent: January 24, 2017Assignee: MAG Aerospace Industries, LLCInventors: Razmik B. Boodaghians, Shane Nazari, Christina Ortolan
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Patent number: 9550007Abstract: Exemplary methods and systems for killing or deactivating spores include applying a fluid to a surface containing a spore; and applying direct or indirect plasma to the surface for a period of time. In some embodiments, the fluid includes water. In some embodiments, the spore is Clostridium difficile and in some is Bacillus Anthracis. In some embodiments, the fluid is in the form of a vapor, a fog, a spray, a mist or an aerosol, which may be activated prior to or after applying the fluid to a surface. In some embodiments, peroxynitrite is created in the fluid during the method. Another exemplary embodiment of killing or deactivating a spore includes treating spores with direct plasma or indirect plasma for a period of time and applying an antimicrobial to the spores. In some embodiments, the antimicrobial is an alcohol, a bleach or an alcohol-based sanitizer.Type: GrantFiled: March 17, 2014Date of Patent: January 24, 2017Assignee: EP Technologies LLCInventors: Tsung-Chan Tsai, Sameer Kalghatgi, Daphne Pappas Antonakas, Robert L. Gray
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Patent number: 9550008Abstract: A Two-part, Syringe-based Electrochemical Dispenser. The dispenser consists of a disposable syringe-like fluid storage reservoir and a reusable fluid driver. The driver is located at the proximal end of a conventional syringe; the fluid exit port at the distal end. The driver generates a gas that inflates an elongated bladder situated within the filled syringe. Expansion of the bladder releases liquid at a rate nearly identical to the gas generation rate. The dispenser is held in a vertical position with the distal end pointed downward. Liquid is released drop-wise onto a porous material from which it can evaporate. A battery-driven electrochemical oxygen generator is the gas source. Means to attach the dispenser in its vertical position are provided. Such dispensing devices can be used to release pheromones, repellants, insecticides, fragrances, etc.Type: GrantFiled: October 12, 2011Date of Patent: January 24, 2017Assignee: M&R Consulting Services, Inc.Inventors: Henri Maget, Mark Johansson
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Patent number: 9550009Abstract: A system is provided for treating a space at least partially enclosed by a wall with an aerosolized compound. The system includes a discharge unit, a liquid diffusion appliance, and a conduit extending therebetween. The discharge unit is mounted to a first side of the wall and includes an aerosol outlet in fluid communication with the space to be treated. The liquid diffusion appliance is mounted to a second side of the wall and includes a control system for operating the liquid diffusion appliance to generate and discharge an aerosolized compound from an appliance outlet. The conduit couples the appliance outlet with the discharge unit and defines a passageway through the wall through which the aerosolized compound travels to be discharged into the space to be treated.Type: GrantFiled: November 2, 2015Date of Patent: January 24, 2017Assignee: Prolitec Inc.Inventor: Matthew Ansley
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Patent number: 9550010Abstract: Methods and articles of manufacture for treating patients with degenerative bone are provided. The methods are useful to improve bone quality in a localized area of a degenerative bone (e.g., osteopenic or osteoporotic bone), such as by improving BMD to be substantially similar to BMD in an average, healthy individual at the age of peak BMD. The methods can comprise forming a void in a localized area of the degenerative bone and filling the void with a bone regenerative material that causes generation of new, healthy, natural bone material. The articles of manufacture can comprise kits formed of various materials useful in the inventive methods for improving bone quality.Type: GrantFiled: June 30, 2011Date of Patent: January 24, 2017Assignee: Agnovos Healthcare, LLCInventors: Olaf Schulz, James Howe, Rick Swaim, Bryan Huber, Joel Batts, David Harness, Ryan Belaney
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Patent number: 9550011Abstract: A functionalized polymer system is described herein for preparing and/or modifying biological implants and prostheses. In one aspect, the polymer system once applied to the surface of a biological implant or prosthesis, or once used in preparing a biological implant or prosthesis comprises a surface that is more hydrophilic, more wettable, more comfortable, resists cell adhesion, resists protein deposition, or a combination thereof. In one embodiment, a coated biological implant or prosthetic is described herein. The coated biological implant or prosthetic comprises a substrate forming the basic structure of the implant or prosthetic, and a coating comprising a polymer, where the coating is capable of resisting cell adhesion, protein deposition, or a combination thereof.Type: GrantFiled: May 3, 2013Date of Patent: January 24, 2017Assignee: Indiana University Research and Technology CorporationInventor: Dong Xie
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Patent number: 9550012Abstract: The invention provides a novel composite bone graft system utilizing a porous collagen scaffold having a matrix impregnated with calcium phosphate particles and more than one bioactive agent, one of which is conjugated to the matrix. The graft system exhibits increased mechanical strength and osteogenic properties by providing sites for tissue attachment and propagation. The bioactive agents are delivered to the scaffold via different mechanisms to enable sequential and sustained release of the bioactive agents over time.Type: GrantFiled: August 5, 2014Date of Patent: January 24, 2017Assignee: University of Notre Dame Du LacInventors: Ryan K. Roeder, Matthew J. Meagher, Robert J. Kane
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Patent number: 9550013Abstract: A medical guide wire which has a core wire having a distal end-side small-diameter portion and a proximal end-side large-diameter portion having a larger outside diameter than the outside diameter of the distal end-side small-diameter portion, and a coil spring installed on an outer periphery of the distal end-side small-diameter portion of the core wire along an axial direction and fixed to the core wire at at least the front end portion and rear end portion thereof. The outside diameter of the proximal end-side large-diameter portion of the core wire and the outside diameter of coil of the coil spring are each at most 0.012 inch. The front end portion of the coil spring is fixed to the core wire by gold-containing solder. The length of a distal end portion stiffened by the gold-containing solder is 0.1 to 0.5 mm. The medical guide wire is high in fixing strength of the coil spring to the core wire and can shorten a shaping length compared with a conventional medical guide wire.Type: GrantFiled: February 9, 2010Date of Patent: January 24, 2017Assignee: JAPAN LIFELINE CO., LTD.Inventor: Hironori Kawasaki
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Patent number: 9550014Abstract: A uterine contractile device includes a series of perforated tubes, a sealing balloon, and an additional connecting tube to deliver a vacuum force inside the lumen of a postpartum uterus. The uterine contractile device may be used after child birth to facilitate contraction of a woman's uterus. By facilitating contraction of the uterus, a medical professional may achieve immediate and sustained hemostasis of the mother.Type: GrantFiled: March 15, 2012Date of Patent: January 24, 2017Assignee: InPress Technologies, Inc.Inventors: Alex James Norred, George Cochran Harper, David Lagrew, Davis Reed Carlin, Jan Segnitz, Amelia Michele Degenkolb
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Patent number: 9550015Abstract: Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.Type: GrantFiled: February 27, 2015Date of Patent: January 24, 2017Assignee: Biomet Biologies, LLCInventor: Alan Gray
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Patent number: 9550016Abstract: Described are systems, methods, and kits for compression sedimentation and whole blood separation. For example, a compression sedimentation system may include a compression stage configured to accept a flexible reservoir configured to contain a liquid mixture. The compression stage may include a base substrate and a compression substrate configured to apply a force to the flexible reservoir effective to create a pressure in the liquid mixture. An apparatus for whole blood separation may include a sedimentation system that separates whole blood into a supernatant including platelet rich plasma and a subnatant including red blood cells. At least one platelet-concentrating device may be included to receive the supernatant including the PRP and to separate a platelet concentrate and a platelet poor plasma from the supernatant.Type: GrantFiled: January 20, 2015Date of Patent: January 24, 2017Assignee: Halcyon Biomedical, IncorporatedInventor: Sean C. Gifford
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Patent number: 9550017Abstract: An intravascular blood pump having a drive section (11), a catheter (14) fastened to the drive section proximally and a pump section (12) fastened to the drive section distally possesses an electric motor (21) whose motor shaft (25) is mounted in the drive section (11) with two radial sliding bearings (27, 31) and an axial sliding bearing (40). During operation, purge fluid is conveyed through the bearing gap of the axial sliding bearing (40) and further through the radial sliding bearing (31) at the distal end of the drive section (11). The purge fluid is highly viscous, for example 20% glucose solution.Type: GrantFiled: February 14, 2013Date of Patent: January 24, 2017Assignee: Abiomed Europe GMBHInventors: Gerd Spanier, Frank Kirchhoff, Thorsten Siess, Dirk Michels
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Patent number: 9550018Abstract: A pump cassette is disclosed. The pump cassette includes a housing having at least, one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.Type: GrantFiled: February 29, 2016Date of Patent: January 24, 2017Assignee: DEKA Products Limited PartnershipInventors: Jason A. Demers, Michael J. Wilt, Kevin L. Grant, James D. Dale, Brian D. Tracey
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Patent number: 9550019Abstract: A capillary dialyzer comprises: a) a housing; a bundle of semi-permeable hollow fiber membranes; c) end walls supporting the first and second ends of the hollow fiber membranes; d) a first end cap covering a first end of the housing and a second end cap covering a second end of the housing; e) an inlet and an outlet; f) support rings; and g) sealing rings interposed between the end wall and the first end cap and between the end wall and the second end cap, respectively. A circular groove of the end cap which receives the wall of the housing comprises indentations for creating a fluid connection between the inside of the capillary dialyzer and its exterior when the end caps are mounted on the housing but have not yet been welded to the housing.Type: GrantFiled: June 20, 2013Date of Patent: January 24, 2017Assignee: Gambro Lundia ABInventors: Reinhold Buck, Roland Henle, Juergen Eichinger
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Patent number: 9550020Abstract: A dialysis system includes a dialysis fluid cassette-based membrane blood pump; a dialyzer in fluid communication with the blood pump; first and second dialysis fluid cassette-based balance chambers each having (i) a fresh dialysis fluid compartment in fluid communication with the dialyzer and (ii) a spent dialysis fluid compartment; a dialysis fluid cassette-based fresh dialysis fluid membrane pump in fluid communication with the fresh dialysis fluid compartments of the first and second balance chambers; a dialysis fluid cassette-based spent dialysis fluid membrane pump in fluid communication with the dialyzer and the spent dialysis fluid compartments of the first and second balance chambers; and arterial and venous lines in fluid communication with the dialyzer for patient connection, the arterial and venous lines each including a contact used for electrically detecting a patient access disconnection.Type: GrantFiled: May 13, 2015Date of Patent: January 24, 2017Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
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Patent number: 9550021Abstract: The present invention relates to a method for querying a specification feature arranged in, at or on a medical technical functional means, the method comprising the step of: querying the specification feature by means of a medical device functionally coupled to or to be coupled to the medical technical functional means or by means of a device or means connected to or being arranged in signal transmission with the medical technical treatment apparatus. The invention further relates to a medical technical functional means, a medical device and a control unit. Furthermore, the present invention relates to a digital storage medium, a computer program product and a computer program.Type: GrantFiled: January 18, 2012Date of Patent: January 24, 2017Assignee: Fresenius Medical Care Deutschland GmbHInventors: Josef Beden, Juergen Klewinghaus
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Patent number: 9550022Abstract: Provided is a method of treating arterial hypertension in a patient. The method comprises selecting a patient suffering from arterial hypertension and creating a flow pathway between a first vascular location and a second vascular location. The first vascular location comprises a source of arterial blood and the second vascular location comprises a source of venous blood. The method causes a reduction in diastolic pressure and a reduction in systolic pressure; and the reduction in diastolic pressure is to an extent at least approximating the reduction in systolic pressure. Systems and devices for creating a flow pathway are also provided.Type: GrantFiled: March 25, 2015Date of Patent: January 24, 2017Assignee: Rox Medical, Inc.Inventors: Rodney Brenneman, Brad Kellerman, J. Christopher Flaherty
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Patent number: 9550023Abstract: A removable material is deposited or otherwise applied to a flat substrate surface in a pattern corresponding to desired corrugations in a membrane, e.g., a deflection diaphragm. The applied material serves as a scaffold for a polymeric material, which is applied thereover, and following cure or hardening, the polymeric material is removed to form a finished corrugated membrane.Type: GrantFiled: June 27, 2014Date of Patent: January 24, 2017Assignee: MiniPumps, LLCInventors: Changlin Pang, Jason Shih, Fukang Jiang, Changgeng Liu, Sean Caffey, Andrew Urazaki
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Patent number: 9550024Abstract: An infusion adapter for connection with an infusion fluid container includes a connection portion including an anchor component for connecting to an injection port of the infusion fluid container, and a first port adapted for connection with a syringe assembly containing a medication fluid. The first port is in fluid communication with the connection portion. The anchor component is configured to securely connect the infusion adapter to the infusion fluid container to substantially prevent disconnection of the infusion adapter from the infusion fluid container once the infusion adapter is connected to the infusion fluid container.Type: GrantFiled: November 27, 2013Date of Patent: January 24, 2017Assignee: Becton Dickinson and Company LimitedInventors: Gert Hanner, Fredrik Stoltz, Alpa Patel, Weston F. Harding, Paul Fearis
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Patent number: 9550025Abstract: An injector for delivering medicament comprises a collapsible container (1002) for containing the liquid medicament, a normally-closed valve (1004) coupled to the collapsible container (1002) for retaining the liquid medicament within the collapsible container and an injection means (1006) for delivering the liquid medicament from the collapsible container. The liquid medicament is maintained under pressure by a pressurizing means (1003) which pressurizes the liquid medicament such that it is delivered by the injection means (1006) when the normally-closed valve (1004) is opened.Type: GrantFiled: March 25, 2011Date of Patent: January 24, 2017Assignee: NEW INJECTION SYSTEMS LTD.Inventor: Stephen Terence Dunne
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Patent number: 9550026Abstract: It is possible to feed an injection objective substance to a depth of a skin structure of an objective living body without using any injection needle. A syringe having no injection needle comprises an ignition device which includes an ignition charge containing a fuel component and an oxidizing agent component, a combustion chamber into which a combustion product produced by a reaction of the fuel component and the oxidizing agent component during combustion of the ignition charge is allowed to flow and which accommodates a gas generating agent that is combustible by the combustion product to generate a predetermined gas, and an enclosing unit which encloses the injection objective substance, wherein the injection objective substance enclosed in the enclosing unit is pressurized by a pressure in the combustion chamber in this construction.Type: GrantFiled: September 22, 2011Date of Patent: January 24, 2017Assignee: DAICEL CORPORATIONInventor: Shingo Oda
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Patent number: 9550027Abstract: A medicine injection device comprises a cartridge having a cartridge barrel and a plunger having a plunger shaft slidable within the cartridge barrel. The cartridge may have, e.g., a pre-filled medicine. The medicine injection device further comprises a body having a proximal end, a distal end, and a cavity in which the cartridge barrel is disposed. The proximal end of the body may optionally form a finger grip. The medicine injection device further comprises a plunger locking mechanism attached to the proximal end of the body. The plunger locking mechanism comprises a member with an aperture slidably engaged with the plunger shaft. The locking mechanism is configured for preventing the plunger from being removed from the cartridge barrel. For example, the plunger shaft may include a locking stop, e.g., a flange, that engages with the aperture in an interference arrangement.Type: GrantFiled: December 16, 2013Date of Patent: January 24, 2017Assignee: Safety Syringes, Inc.Inventor: Lars Tommy Westbye
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Patent number: 9550028Abstract: A device for processing a biological material is disclosed. The device includes a syringe barrel comprising beads, a filter positioned at a close end of the barrel, a plunger insertable into the barrel through an open end, and a needle. The plunger includes a paddle assembly that is configured to mix a biological material with the beads after the biological material has been harvested from a patient.Type: GrantFiled: May 6, 2014Date of Patent: January 24, 2017Assignee: Biomet Biologics, LLC.Inventors: William King, Jennifer E. Woodell-May
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Patent number: 9550029Abstract: Systems and methods are described herein for guided injection, which include: one or more controllable light-emitting elements configured to emit non-destructive light and a computing device operably connected to the one or more controllable light-emitting elements configured to emit non-destructive light, the computing device including a processor operable to receive at least one digital representation of a body region of an individual, the body region of the individual including one or more physical registration landmarks, the at least one digital representation including one or more digitally registered injection sites and one or more digital registration landmarks corresponding to the one or more physical registration landmarks on the body region; and control the one or more controllable light-emitting elements to illuminate a location of a surface of the body region of the individual corresponding in location to at least one of the one or more digitally registered injection sites.Type: GrantFiled: October 30, 2012Date of Patent: January 24, 2017Assignee: Elwha LLCInventors: Edward S. Boyden, Hon Wah Chin, Gregory J. Della Rocca, Daniel Hawkins, Roderick A. Hyde, Robert Langer, Eric C. Leuthardt, Terence Myckatyn, Parag Jitendra Parikh, Dennis J. Rivet, Joshua S. Shimony, Michael A. Smith, Elizabeth A. Sweeney, Clarence T. Tegreene
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Patent number: 9550030Abstract: Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.Type: GrantFiled: July 20, 2011Date of Patent: January 24, 2017Assignee: Becton, Dickinson and CompanyInventors: Ivan Zivkovic, Jorgen Hager, Ulf Handberg, Gert Hanner, Thomas Holma, Ulf Wahlberg
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Patent number: 9550031Abstract: A system and method for accurately and reliably determining and recording the time, date and location where a medication is used, and a system and method for transmitting, collecting, and using that data to improve clinical care, disease management, and public health surveillance. The device allows information concerning drug usage, including the time, date and location of use, to be transmitted to a remote network computer system so that the data can be evaluated to determine current impairment and future risk, and to identify changes in the frequency, timing, or location of medication usage indicative of change in disease control or management, and to examine spatial, temporal or demographic patterns of medication use or absence of use among individuals and groups. In addition, the device may further be configured to transmit signals indicative of its status, condition or other results to the remote network computer system.Type: GrantFiled: January 5, 2009Date of Patent: January 24, 2017Assignee: Reciprocal Labs CorporationInventors: John David Van Sickle, Gregory F. Tracy
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Patent number: 9550032Abstract: A wearable wrist inhaler includes a wristband having a first end and a second end configured for wear about a user's wrist. An inhaler unit is coupled to the wristband displaced from the first end and the second end, the inhaler unit including a housing having a plurality of walls defining an interior area and an outlet port in communication with the interior area. A watch assembly is positioned atop the housing of the inhaler unit, the watch assembly energized by a battery and includes a display configured to indicate a time of day. A dosage chamber including a medicament is positioned in the interior area of the housing. A dispensing assembly is communication with the inhaler medicament that is configured to dispense an individual portion of the medicament via the outlet port upon demand by a user.Type: GrantFiled: October 12, 2015Date of Patent: January 24, 2017Inventor: Kendra Baldwin
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Patent number: 9550033Abstract: An apparatus for metering the delivery of an aerosol. The apparatus has a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus may also include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region. An atomizer, coupled to the fluid region, is configured to aerosolize at least a portion of the fluid.Type: GrantFiled: July 14, 2015Date of Patent: January 24, 2017Assignee: DEKA Products Limited PartnershipInventors: Russell H. Beavis, Larry B. Gray, Derek G. Kane
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Patent number: 9550034Abstract: A method for metering the delivery of a fluid. The apparatus has a variable acoustic source and a microphone, both acoustically coupled to a volume having a fluid region and an air region. The apparatus may also include a processor to determine a volume of the air region based on signals received from the microphone and the variable acoustic source. A fluid valve is coupled to the processor, and is configured to allow an amount of fluid to exit the fluid region associated with the volume of the air region.Type: GrantFiled: August 4, 2015Date of Patent: January 24, 2017Assignee: DEKA Products Limited PartnershipInventors: Russell H. Beavis, Larry B. Gray, Derek G. Kane
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Patent number: 9550035Abstract: A method to deliver medication. The apparatus has an acoustic volume sensor that acoustically excites a reference volume and variable-volume chamber with an acoustic source and measures the acoustic response with microphones acoustically coupled to the reference and the variable-volume chamber. A disposable drug cassette is coupled to the acoustic volume sensor and includes a drug reservoir and valve. The method includes receiving a volume signal and inputs from a user input or a second sensor and controlling the valve based on these inputs.Type: GrantFiled: September 30, 2015Date of Patent: January 24, 2017Assignee: DEKA Products Limited PartnershipInventors: Russell H. Beavis, Larry B. Gray, Derek G. Kane
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Patent number: 9550036Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.Type: GrantFiled: September 3, 2013Date of Patent: January 24, 2017Assignee: Impel NeuroPharma Inc.Inventors: John D. Hoekman, Michael Hite, Alan Brunelle, Joel Relethford, Rodney J. Y. Ho
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Patent number: 9550037Abstract: A ventilator (10) that pressurizes gas from a body of gas to provide a flow of gas to an airway of a subject (14) such that the gas flow mechanically facilitates the respiration of the subject (14). In order to enhance the comfort of the subject (14) during ventilation by the ventilator (10), the ventilator (10) enables the subject (14) to make unsupervised adjustments to one or more of the properties of the gas flow, within predetermined limits.Type: GrantFiled: January 9, 2009Date of Patent: January 24, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Adam Seiver, Samir Ahmad, Peter R. Doyle
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Patent number: 9550038Abstract: In one embodiment, a nasal cannula is shaped to fit within a user's nares, where the nasal cannula includes at least one prong allowing high flow delivery of humidified gases and creates positive airway pressure in the patient's airway. The prongs have angled ends such that, in use, gases flowing through the prongs are directed to the user's nasal passages. The nasal cannula body is partially swiveling and preferably has a ball joint connector. In another embodiment the nasal cannula may have at least one flared end prong that preferably seals within a patient's nare.Type: GrantFiled: October 19, 2015Date of Patent: January 24, 2017Assignee: Fisher & Paykel Healthcare LimitedInventors: Alastair Edwin McAuley, Craig Robert Prentice, Oliver Gleeson
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Patent number: 9550039Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.Type: GrantFiled: June 23, 2014Date of Patent: January 24, 2017Assignee: Mallinckrodt Hospital Products IP LimitedInventors: Craig Flanagan, Simon Freed, John Klaus, Thomas Kohlmann, Martin D. Meglasson, Manesh Naidu, Parag Shah
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Patent number: 9550040Abstract: Described are methods for safer nitric oxide delivery, as well as apparatuses for performing these methods. The methods may include detecting the presence or absence of a nasal cannula, and stopping the delivery of nitric oxide or providing an alert if the cannula is disconnected. The methods may also include purging the nasal cannula if it is reconnected after a disconnection or if it is replaced by a new cannula. Other methods pertain to automatic purging of the delivery conduit if the elapsed time between successive deliveries of therapeutic gas exceeds a predetermined period of time.Type: GrantFiled: August 17, 2015Date of Patent: January 24, 2017Assignee: Mallinckrodt Hospital Products IP LimitedInventors: Jaron M. Acker, Thomas Kohlmann
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Patent number: 9550041Abstract: A steerable catheter includes a body portion, a flexible catheter body with a proximal end and a distal tip and a continuous steering wire passing through the flexible body from the proximal end to the distal tip and turning back through the flexible body from the distal tip to the proximal end.Type: GrantFiled: February 1, 2012Date of Patent: January 24, 2017Assignee: ADVANCED PAIN CENTER, LLC.Inventor: Raymond Bedell
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Patent number: 9550042Abstract: A catheter which exhibits excellent anti-kinking properties while avoiding interference with respect to an object moving inside the lumen of the catheter includes: an elongated catheter main body having a longitudinally extending lumen; a tubular-shaped guide wire insertion portion on the distal end of the catheter main body through which a guide wire is insertable, and which includes a distal opening portion and a proximal opening portion; and a reinforcement portion having a coil portion in which at least a portion of the reinforcement portion is arranged proximally of the proximal opening portion and is formed by a wound wire element, and an extension portion extending from the wire element of the coil portion in the distal direction away from the proximal opening portion, and wherein the reinforcement portion is positioned between the inner surface and the outer surface of the lumen of the catheter main body.Type: GrantFiled: February 7, 2012Date of Patent: January 24, 2017Assignee: TERUMO KABUSHIKI KAISHAInventor: Hiromichi Tanioka