Abstract: The invention relates to a dry building material mixture, in particular a plastering mortar, the dry building material mixture comprising at least on aerogel.

Abstract: The invention concerns a method for producing pulverulent hardening accelerators by reactive spray drying, where an aqueous phase I comprising calcium ions, and an aqueous phase II comprising sulphate ions, the molar ratio of the calcium ions to the sulphate ions being from 1/5 to 5/1, are contacted at a spray nozzle, and the phases I and II contacted with one another at the spray nozzle are sprayed in a streaming environment of drying gas. Likewise concerned are the pulverulent hardening accelerators producible by the method of the invention, and their use for accelerating the hardening of bassanite and/or anhydrite with formation of gypsum.

Abstract: The invention relates to a composition comprising at least 10 wt. % of a binder based on calcium sulfate and 0.005 to 5 wt. % of an additive made of at least one water-soluble salt of a multivalent metal cation, at least one compound which is capable of releasing an anion that forms a poorly soluble salt together with the multivalent metal cation, and at least one polymer dispersant which comprises anionic and/or anionogenic groups and polyether side chains. The invention further relates to a method for producing said composition and to the use thereof as a calcium sulfate flow screed, a flowable calcium sulfate filler compound, or an earth-moist calcium sulfate screed.

Abstract: A method and composition for reducing hydrogen sulfide generated or emitted from an asphalt composition are disclosed. In certain aspects, a method for reducing hydrogen sulfide emissions from an asphalt composition is provided wherein an additive is mixed with the asphalt composition and the additive is a copper-based complex. The asphalt composition can include asphalt and an asphalt modifying acid. The copper-based complex can comprise copper carboxylate. The copper carboxylate can be an oil-soluble metal organic.

Abstract: A binder composition for enhanced mortars and coatings, comprising a first conventional mineral component and a second component based on powdery slaked lime, wherein said second component based on powdery slaked lime has a specific surface area calculated according to the BET method of less than 12 m2/g, advantageously less than 11 m2/g, in particular less than 10 m2/g, preferably less than 9 m2/g and its uses as well as the enhanced coating or mortar systems comprising an aggregate of the mineral type and the aforesaid composition.

Abstract: The present invention relates to a method of manufacturing a ceramic article (3) from a metal or metal matrix composite preform (1) provided by 3D-printing or by 3D-weaving. The preform (1) is placed in a heating chamber (2), and a predetermined time-temperature profile is applied in order to controllably react the preform (1) with a gas introduced into the heating chamber (2). The metal, the gas and the time-temperature profile are chosen so as to induce a metal-gas reaction resulting in at least a part of the preform (1) transforming into a ceramic. Preferred embodiments of the invention comprises a first oxidation stage involving a metal-gas reaction in order to form a supporting oxide layer (5) at the surface of the metal, followed by a second stage in which the heating chamber (2) is heated to a temperature above the melting point of the metal to increase the kinetics of the chemical reaction. The invention also relates to a number of advantageous uses of a ceramic article manufactured as described.

Abstract: Set forth herein are processes and materials for making ceramic thin films by casting ceramic source powders and precursor reactants, binders, and functional additives into unsintered thin films and subsequently sintering the thin films under controlled atmospheres and on specific substrates.

Abstract: An environmental barrier coating having improved CMAS resistance for a ceramic matrix composite, an article comprising an environmental barrier coating having improved CMAS resistance, and a method of forming an environmental barrier coating having improved CMAS resistance are disclosed. The environmental barrier coating may include a rare earth silicate and a rare earth titanate. The ceramic matrix composite may be a silicon carbide-based composite.

Abstract: The invention relates to a composition (batch) for producing a shaped refractory ceramic product, a method for producing a shaped refractory ceramic product, and a shaped refractory ceramic product.

Abstract: A carbon fiber preform that includes a plurality of fibrous layers stacked together and a plurality of sacrificial fibers that bind the plurality of fibrous layers together, where at least one fibrous layer of the plurality of fibrous layers includes a plurality of carbon fibers or carbon fiber precursor fibers.

Abstract: A method for producing an insulating composite block including a mineral foam, includes: providing a block including at least one cell having walls which are either sufficiently humid or consist of a water-repellent material, and b. filling the cell with a mineral foam that does not substantially include any calcium aluminate.

Abstract: The present invention provides for biochar coated particles and a method for coating the particles with biochar.

Abstract: Syrup produced in a lignocellulosic biomass fermentation process is used as a binder for soil conditioning materials to make an agricultural composition that is easily handled and applied. The syrup binds powdery soil conditioning materials such as lime and gypsum to form pellets or granules.

Abstract: The invention relates to a fertilizing product, for example a potash fertilizer, the release of which is controlled and delayed by a coating comprising a first layer based on a polysaccharide resin obtained from a vegetable oi, and a second layer based on a non-hydrated cement.

Abstract: Reaction products and methods for making and using such reaction products are provided. For example, a reaction product comprising an adduct formed from urea, formaldehyde, and a urease inhibitor is described, which can be provided in various forms. For example, such a reaction product can be in the form of a solid or solution. Such a reaction product can also be combined with one or more additional components, including but not limited to, additional urease inhibitor and/or a nitrogen-based fertilizer composition.

Abstract: A process for producing a methane-containing gas mixture includes the steps of: (i) passing a first feed gas mixture including hydrogen and carbon dioxide through a bed of methanation catalyst to react a portion of the hydrogen with at least a portion of the carbon dioxide and form a methane-containing gas mixture containing residual hydrogen, (ii) adding an oxygen-containing gas to the methane-containing gas mixture containing residual hydrogen to form a second feed gas mixture, and (iii) passing the second feed gas mixture through a bed of an oxidation catalyst to react the residual hydrogen and oxygen to form a hydrogen depleted methane-containing gas mixture.

Abstract: Embodiments of the present invention are directed to the conversion of a source material (e.g., a depolymerized oligosaccharide mixture, a monomeric sugar, a hydrolysate, or a mixture of monomeric sugars) to intermediate molecules containing 7 to 26 contiguous carbon atoms. These intermediates may also be converted to saturated hydrocarbons. Such saturated hydrocarbons are useful as, for example, fuels.

Abstract: Ethylene is produced from ethanol in a one-step process by reacting ethanol with hydrogen chloride over a silica alumina catalyst.

Abstract: Production of a mixture of ethylene and propylene from a mixture containing ethanol and isopropanol and having a water content between 30 and 75 wt. % is obtained by a process comprising: a) contacting the mixture in a dehydration unit with a dehydration catalyst chosen from: an alumina (A) having a BET specific surface area between 200 and 350 m2/g, a mean mesopore diameter between 5 and 15 nm, a sodium content of less than 50 ppm by weight, and a sulphur content of less than 40 ppm by weight; and an alumina (B) having a BET specific surface area between 130 and 180 m2/g, a mean mesopore diameter between 14 and 20 nm, a sodium content between 300 and 600 ppm by weight, and a sulphur content between 800 and 1300 ppm by weight; b) withdrawing an effluent containing ethylene and propylene from the dehydration unit.

Abstract: Processes for providing a high purity olefin product are described. The processes involve dehydrating a feedstream comprising a mixture of alcohols having 3 to 8 carbon atoms and forming a mixed olefin stream and a water stream, the mixed olefin stream comprising a mixture of olefins having 3 to 8 carbon atoms. The mixed olefin stream is separated into at least a C3 olefin stream comprising olefins having 3 carbon atoms and a C4-8 olefin stream comprising olefins having 4 to 8 carbon atoms. The C4-8 olefin stream is separated into a C4 olefin stream comprising olefins having 4 carbon atoms and a C5-8 olefin stream comprising olefins having 5 to 8 carbon atoms. At least one of the C3 olefin stream and the C4 olefin stream is purified.

Abstract: Improved alkylation catalysts, alkylation methods, and methods of making alkylation catalysts are described. The alkylation method comprises reaction over a solid acid, zeolite-based catalyst and can be conducted for relatively long periods at steady state conditions. The alkylation catalyst comprises a crystalline zeolite structure, a Si/Al molar ratio of 20 or less, less than 0.5 weight percent alkali metals, and further having a characteristic catalyst life property. Some catalysts may contain rare earth elements in the range of 10 to 35 wt %. One method of making a catalyst includes a calcination step following exchange of the rare earth element(s) conducted at a temperature of at least 575° C. to stabilize the resulting structure followed by an deammoniation treatment. An improved method of deammoniation uses low temperature oxidation.

Abstract: A method of alkylating a hydrocarbon stream including: providing a feed stream that includes hydrocarbons and ionic liquid catalyst; passing the feed stream through a low efficiency mixer to create a mixed stream, whereby the low efficiency mixer creates droplets within the feed stream that are primarily within a predetermined size range; passing the mixed stream and an olefin stream into a reactor; performing an alkylation reaction within the reactor, thereby forming a reacted stream; and separating the reacted stream into a settled ionic liquid catalyst stream and a hydrocarbon stream through the use of at least one hydrocyclone.

Abstract: A method for producing a tetrafluoroolefin, such as 2,3,3,3-tetrafluoropropene (HFO-1234yf), comprises dehydrofluorinating a pentafluoroalkane in a gas phase in the presence of a catalyst comprising chromium oxyfluoride. In a preferred embodiment, 2,3,3,3-tetrafluoropropene (HFO-1234yf) is produced by forming a catalyst comprising chromium oxyfluoride by calcining CrF3.xH2O, where x is 1-10, in the presence of a flowing gas comprising nitrogen to form a calcined chromium oxyfluoride, and dehydrofluorinating 1,1,1,2,2-pentafluoropropane (HFC-245cb) in a gas phase in the presence of the catalyst to form the 2,3,3,3-tetrafluoropropene (HFO-1234yf).

Abstract: This invention relates to a process for producing ethanol comprises supplying a feed comprising carbon monoxide, hydrogen and dimethyl ether to a reaction zone operated under conditions such that (i) part of the carbon monoxide in the feed reacts with part of the hydrogen in the feed to produce methanol; (ii) part of the carbon monoxide in the feed reacts with at least part of the dimethyl ether in the feed to produce methyl acetate; and (iii) part of the hydrogen in the feed reacts with at least part of the methyl acetate produced in (ii) to produce an effluent comprising methanol and ethanol. At least part of the ethanol is recovered from the effluent and at least part of the methanol is dehydrated to produce dimethyl ether, which is recycled to the reaction zone.

Abstract: The purpose of the present invention is to provide a spherical or ellipsoidal magnesium alcoholate having a narrow particle size distribution even when the particle size is small. The present invention provides a method for producing a magnesium alcoholate by adding in a portionwise manner to a reaction system and reacting, metallic magnesium, an alcohol, and at least one of a halogen or a halogen atom-containing compound in the reaction system under alcohol reflux, which is a method for producing a magnesium alcoholate characterized in that a mixture of metallic magnesium, an alcohol, and at least one of a halogen or a halogen atom-containing compound is added to the reaction system at each portionwise addition.

Abstract: A method and system for recovering a volatile organic compound from a dilute aqueous phase. The method may include separating volatile organic compound from the aqueous phase by using carrier gas to generate a solvent-laden vapor stream, feeding a solvent-laden vapor stream to a mass of carbon adsorbent and enabling the solvent to be absorbed and separated from the solvent-laden vapor stream, releasing the absorbed volatile organic compound, and condensing the released volatile organic compound to form a condensate. The system may include a vapor phase source containing ethanol, at least one carbon bed containing a mass of coconut shell carbon, a steam source in fluid communication with the carbon bed, and a condenser in fluid communication with the carbon bed. The method and system may also utilize microbeads as an absorbent and may be configured so the capacity is scalable from lab scale to production scale.

Abstract: A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil.

Abstract: The invention relates to compounds of the formula Ar(—CH2C6Br5)y, wherein Ar indicates a structure comprising one or more six-membered aromatic ring(s) and —CH2C6Br5 indicates a pentabromobenzyl group, characterized in that at least one carbon atom of said six-membered aromatic ring(s) is bonded to the benzylic carbon of said —CH2C6Br5 group, wherein y, which indicates the number of the —CH2C6Br5 groups in said compound, is not less than 1. Processes for preparing the compounds and their use as flame retardants are also disclosed.

Abstract: Disclosed herein are compositions and methods related to the hydroformylation of cyclododecatriene to form cyclododecatriene trialdehyde, and the conversion of the trialdehyde to the polyphenols of Formula 1: where R, m p and Q are as defined herein. Curable compositions comprising compounds of Formula 1, including powder coating compositions, and methods of curing the compositions are also disclosed.

Abstract: The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C3 (tris malonic acid C60) or malonic acid derivatives.

Abstract: Provided is a method that can produce phenyl(meth)acrylate inexpensively and at high yields. The phenyl(meth)acrylate production method of the present invention reacts (meth)acrylic acid with carbonic acid diphenyl. Further, the phenyl(meth)acrylate composition of the present invention contains 90-99.999 wt % phenyl(meth)acrylate and 0.001-10% carbonic acid diphenyl. Or, the phenyl(meth)acrylate composition of the present invention contains 90-99.999 wt % phenyl(meth)acrylate and 0.001-10 wt % of a specified compound.

Abstract: The invention relates to compounds of formula (I) where m and n are each independently 0 or 1; R1, R2, R3, R4 are each independently selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl, —(C3-C20)-heteroaryl; at least one of the R1, R2, R3, R4 radicals is a —(C3-C20)-heteroaryl radical; and R1, R2, R3, R4, if they are —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl or —(C3-C20)-heteroaryl, may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C1-C12)-alkyl-(C6-C20)-aryl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S—(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —CO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —(C6-C20)-aryl, —(C6-C20)-aryl-(C1-C12)-alkyl, —(C6-C20)-aryl-O—(C1-C12)-alkyl, —(C3-C20)-heteroaryl, —(C3-C20)-heteroary

Abstract: The invention relates to compounds of formula (I) where R1, R2, R3, R4 are each independently selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl, —(C3-C20)-heteroaryl; at least one of the R1, R2, R3, R4 radicals is a —(C3-C20)-heteroaryl radical; and R1, R2, R3, R4, if they are —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl or —(C3-C20)-heteroaryl, may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C1-C12)-alkyl-(C6-C20)-aryl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S—(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —CO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —(C6-C20)-aryl, —(C6-C20)-aryl-(C1-C12)-alkyl, —(C6-C20)-aryl-O—(C1-C12)-alkyl, —(C3-C20)-heteroaryl, —(C3-C20)-heteroaryl-(C1-C12)-alkyl, —(C3-C20)-heteroar

Abstract: The invention relates to compounds of formula (I) where R1 is selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl; R2 is selected from —(C3-C12)-heterocycloalkyl, —(C6-C20)-aryl, —(C3-C20)-heteroaryl; R3 is —(C3-C20)-heteroaryl; and R1, R2 and R3 may each independently be substituted by one or more substituents selected from —(C1-C12)-alkyl, —(C3-C12)-cycloalkyl, —(C3-C12)-heterocycloalkyl, —O—(C1-C12)-alkyl, —O—(C1-C12)-alkyl-(C6-C20)-aryl, —O—(C3-C12)-cycloalkyl, —S—(C1-C12)-alkyl, —S—(C3-C12)-cycloalkyl, —COO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —CONH—(C1-C12)-alkyl, —CONH—(C3-C12)-cycloalkyl, —CO—(C1-C12)-alkyl, —COO—(C3-C12)-cycloalkyl, —N—[(C1-C12)-alkyl]2, —(C6-C20)-aryl, —(C6-C20)-aryl-(C1-C12)-alkyl, —(C6-C20)-aryl-O—(C1-C12)-alkyl, —(C3-C20)-heteroaryl, —(C3-C20)-heteroaryl-(C1-C12)-alkyl, —(C3-C20)-heteroaryl-O—(C1-C12)-alkyl, —COOH, —OH, —SO3H, —NH2, halogen.

Abstract: The invention relates to a process to prepare complex oligomeric structures obtained from vegetable oils. The process allows to use a mixture of triglycerides containing dicarboxylic acids produced by the oxidative cleavage of vegetable oils as a starting material, these oils being subjected to a step of heating (condensation) followed by a step of esterification with alcohols at temperatures up to 250° C.

Abstract: The invention provides processes for cleaning carbon dioxide-containing process gases from the preparation of vinyl acetate after reaction of ethylene with acetic acid and oxygen in heterogeneously catalyzed, continuous gas phase processes, characterized in that carbon dioxide-containing process gases, for removal of carbon dioxide, are contacted with one or more scrubbing solutions, and one or more scrubbing solutions comprise one or more oxides of metals (metal oxides) selected from the group comprising vanadium, niobium, tantalum, chromium, molybdenum, manganese and arsenic.

Abstract: The present invention claims a process for preparing high-purity glycerol dimethacrylate comprising <500 ppm of glycidyl methacrylate, characterized in that an aftertreatment with acidic adsorbent is effected.

Abstract: To provide a polyester polyol from which a polyurethane having acid resistance and alkali resistance can be produced. A polyester polyol containing 1,3-propanediol having an alicyclic skeleton in a side chain, 3-methyl-1,5-pentanediol and a dibasic acid component as constituent components.

Abstract: The invention relates to esters of 2-propylheptanoic acid and also to the use of esters of 2-propylheptanoic acid in cosmetic and/or pharmaceutical preparations. The compounds are characterized by the particularly lightweight sensation thereof.

Abstract: Systems and method are provided for reducing the water content in ethanolamine product streams from approximately 0.15%-0.19% by weight of water to approximately 0.02 to approximately 0.04 by weight of water. The reduced water content can be achieved by increasing the processing conditions at the monoethanolamine column by approximately 5% to approximately 20%, more preferably to approximately 10%, and by adding a dummy stream to the monoethanolamine column, which can be recycled to the reactor. The increased processing conditions and dummy stream at the monoethanolamine column can result in the following to achieve said water content: (i) the bottom stream flow rate increase by up to approximately 18.9%; the reboiler duty can be increased by up to 47.9%; and (iii) the condenser duty can be increased by up to approximately 52.5%.

Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.

Abstract: Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.

Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

Abstract: Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A1-Y-A2-Z-L-R??(I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: The present invention relates to a process for preparing 1,1-disubstituted ethylene monomers having general formula (I) from a compound of general formula (II) and an active methylene compound of general formula (III) using a catalytic amount of an ammonium or iminium asalt in homogeneous phase or supported on a solid substrate. Said process allows the direct synthesis of the monomers and finds application in the preparation of a wide variety of monomers. The products obtained are reactive monomers of high purity which find application in the field of fast curing adhesives.

Abstract: A solvent refining method for isocyanate prepared by the phosgene method and multistage absorbing towers used in same. Solvent to be refined which contains water, iron, and/or phosgene, hydrogen chloride and other materials with color is dealt by the present method and multistage absorbing towers, which can effectively prevent a drying agent from absorbing water and hardening, partial overheating in the tower and generating channeling. Meanwhile, the pressure drop is effectively lowered. In addition, the content of water is ?50 ppm, the content of iron is ?5 ppm, the content of phosgene and hydrogen chloride is ?20 ppm, Pt—Co chroma is ?20 in the refined solvent. Therefore, the refined solvent can be used as the solvent for preparing isocyanate in the phosgene method and remarkably improve an L color of isocyanate.

Abstract: Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Abstract: The present invention refers to an amorphous form of a thiocolchicine derivative, IDN 5404, to a process for producing it and to pharmaceutical compositions thereof. The amorphous form is characterised by the XRPD pattern, DSC profile and/or TG/DTA profile.