Abstract: Provided is an air mattress in which internal pressure can be controlled according to the movements of a bed. The air mattress is provided with a plurality of air cell groups lined up in the lengthwise direction of the air mattress, each of which groups is made from a plurality of bladder-shaped cells; an air supply/release pump; and an air tube connecting the air cell groups and the air supply/release pump in an independent system for each air cell group of two or more air cell groups out of said air cell groups. Air supply/release by the air supply/release pump to each of the air cell groups is controlled by a controller, at least a part of information needed to control the bed is received from an external sensor for detecting such information, and air supply/release by the air supply/release pump for each of the air cell groups is controlled on the basis of the received information.

Abstract: This invention makes reference to an autonomous, versatile and non-invasive hyperbaric capsule with a new functional and esthetic design for high-pressured air or oxygen therapies for one or more people which can be installed to any structure. It has vertical to horizontal oscillating effect and features a new bolted gate with a 2-movement, 3-position twin closure mechanism. Also, it has all the necessary equipment already built in ready to be operated according to the wishes of the patient inside or by an assistant in the outside.

Abstract: A premature neonate closed life support system (NCLSS) including: at least one chamber confining a cradle-like neonate support (CLNS) having suitable dimensions and geometric-configuration for accommodating at least one premature neonate having at least two operational configurations, said operational configurations comprising: a first operational OPEN configuration whereby said CLNS is adapted to couple said neonate to at least one life supporting system by means of at least one life supporting coupling line, prior to positioning said CLNS in a medical device; and a second operational air-tight CLOSED configuration whereby said neonate remains continuously coupled to said at least one life supporting system by means of at least one life supporting coupling line, when positioning said CLNS within said medical device. The OPEN and CLOSED configurations are reversible.

Abstract: A positioning device is described for supporting an infant with myelomeningocele during surgery, transport and pre- and post-operative procedures. The device allows the patient to be expeditiously re-positioned from prone to supine and lateral positions and vice versa before, during and after surgery. The device allows access to the myelomeningocele while the patient is secured in the device.

Abstract: A casket system includes a casket container and a height adjustment mechanism. The casket container has a bottom, a head end panel, a foot end panel, and rollers supported by the bottom. The height adjustment mechanism includes a threaded shaft, a worm nut, and a crossbar. The threaded shaft extends at least partly in the vertical direction. The shaft is rotatably coupled to the casket container proximate the head end panel. The worm nut is rigidly secured to the crossbar. The worm nut rotatably engages the threaded shaft and translates rotational movement into axial movement along the shaft. The crossbar includes spaced-apart extensions extending from an edge thereof away from the head end panel. The spaced-apart extensions are configured to contact and engage a casket insert that is sized and configured to receive a deceased. The axial movement of the worm nut causes the crossbar to move vertically with respect to the head end panel.

Abstract: Body containment constructions, materials, and methods of use for bio-cremation processes are disclosed. Preferably, the containment constructions of the present invention provide the functionality of liquid containment and also the functionality of body presentment for viewing purposes, if desired, in addition to bio-degradability. Advantageously, liquid containment is provided in a body containment construction that is sufficiently liquid impervious, allows for body transport by sufficient structural support, and is decomposable within the time period for a bio-cremation process. More preferably, the containment construction will dissolve or decompose within a normal procedural time period without leaving any component remaining from the containment construction.

Abstract: Posture apparatus for rehabilitating alterations of the locomotor system includes a rectangular-shaped platform offering housing to two portions and receive a subject user, each portion respectively including a base reversibly respectively fixed to its corresponding portion and adapted to respectively support a support matching the left foot and a support matching the right foot of the subject; a belt with elastic band adapted to be worn by the subject; at least one elastic cord for connecting the belt with support elements present on the apparatus; at least two telescopic rods adapted to fix at a predetermined height the support elements; the apparatus conferring to the anatomic structures involved in the exercise, and to the feet of the subject, a high number of degrees of freedom of movement, with the matching feet supports divided into two transverse portions which allow the foot to perform a natural helical movement.

Abstract: A walker to assist a person rising from a seated position, the walker comprising: two or more front legs each having a proximal end, a center and a distal end, the distal end being adapted to contact the ground, one or more cross members secured to and joining the front legs to one another, a handle engaged to the proximal end of each front leg, a joint mechanism engaged to each the front leg, and a rear leg having a proximal end and a distal end, the proximal end being engaged to each joint mechanism allowing the rear legs to pivot relative to the front legs.

Abstract: A tactile plate assembly used as a tactile warning device on walkways comprises a plurality of tactile plates with texture for providing tactile awareness. A bracket connects first and second tactile plates to each other. The brackets include holes of sufficient size to allow a substrate such as concrete or asphalt to flow therethrough to anchor the tactile plate assembly in place.

Abstract: A method for the treatment of amblyopia comprising the steps of diagnosis and approval of a patient by a medical practitioner, providing access to an eye-training platform for the approved patient and instructions to the approved patient on using the eye-training platform, preparation of a therapy protocol by the medical practitioner, use of the eye-training platform according to the therapy protocol, recordal of patient results, intermediate examination of the patient and review of patient results, further use of the eye-training platform according to a modified therapy protocol, recordal of further user results, and examination of visual acuity and review of user results by the medical practitioner.

Abstract: A system and methods are disclosed for manipulating soft tissue. In some embodiments, a roller has a cylindrical core with a plurality of protrusions disposed thereon, each protrusion having a height, durometer and radius of curvature and separated axially and circumferentially from nearby protrusions. Spacing between tow protrusions may allow protrusions to contact soft tissue while nearby bony tissue, nerves or wounds are avoided. End caps on the cylindrical core have a major diameter that may be less than, approximately the same as, or greater than the diameter of the cylindrical core and the height of the protrusions. A circumferential band may be devoid of protrusions.

Abstract: A gum massaging tool includes a handle portion which accommodates electric or mechanical members and in which a selector switch is provided in an exposed manner; a fixed shaft portion that is fixed to the handle portion so as to extend from one end of the handle portion and is heated according to an operation of the selector switch; a gum contact portion that is rotatable around a distal end portion of the fixed shaft portion and that includes a carbon body which receives heat from the fixed shaft portion and transfers the heat to a gum contacting surface; and a supporting portion that is rotatably engaged with and supports the gum contact portion and is detachably attached to the handle portion.

Abstract: An integral one piece gum soother with a bristle-less wand, an internal vibrating device, a power supply connected to the internal vibrating device, an on/off switch for activating the internal vibrating device, and a mouth guard connected to the bristle-less wand. The mouth guard can extend at a first angle from the bristle-less wand and a flex neck connected to the bristle-less wand can extend at a second angle from the mouth guard. A hollow membrane-free dual chew tip can be connected to the flex neck, wherein the hollow membrane-free dual chew tip can be configured to sustain a reduced temperature from room temperature of at least 20 degrees Fahrenheit if needed.

Abstract: A system applies cardiopulmonary resuscitation (CPR) to a recipient. An automated controller is provided together with a compression device which periodically applies a force to a recipient's thorax under control of the automated controller. A band is adapted to be placed around a portion of the torso of the recipient corresponding to the recipient's thorax. A driver mechanism shortens and lengthens the circumference of the band. By shortening the circumference of the band, radial forces are created acting on at least lateral and anterior portions of the thorax. A translating mechanism may be provided for translating the radial forces to increase the concentration of anterior radial forces acting on the anterior portion of the thorax. The driver mechanism may comprise a tension device for applying a circumference tensile force to the band. The driver mechanism may comprise an electric motor, a pneumatic linear actuator, or a contracting mechanism defining certain portions of the circumference of the band.

Abstract: A spa according to the present invention includes a shell having a plurality of seating positions formed in the shell, a base supporting the shell, and a hydrotherapy system configured to draw a fluid from the spa and inject the fluid back into said spa as at least one a pressurized jet. The hydrotherapy system includes a pump for circulating the fluid and a jet pod arranged in at least one of the seating positions and in fluid communication with the pump.

Abstract: A storage or infusion bottle (1) has an integrally molded bottle neck (3) with a teat-shaped bottle feature (4, 5) projecting from its mouth end. The closed teat end wall (6, 7) of the bottle feature is puncturable by an infusion needle. A cap (8) is attachable to the bottle neck (3) and has a funnel-shaped cap feature (9, 10) with an interior space accommodating the free end region of the bottle feature (4, 5). The intermediate space between the end wall of the bottle feature (4, 5) and the opposing side of the cap feature (9, 10) is completely filled by a hat-shaped sealing element (11, 12) enclosing the bottle feature (4, 5) at least in its end region remote from the bottle (1).

Abstract: A system for the closed transfer of fluids that provides substantially leak-proof sealing and pressure equalization during engagement of a cannula with a vial, during transfer of a substance from a vial chamber to a barrel chamber via the cannula, and during disengagement of the cannula from the vial is disclosed. The leak-proof sealing of the system substantially prevents leakage of both air and liquid during use of the system. The system of the present disclosure also permits pressure equalization between a vial and the system when the system is attached to the vial. The system is compatible with a needle and syringe assembly for accessing a medication contained within a vial for administering the medication to a patient.

Abstract: A pill dispensing system that includes pill packages that can be used to dispense pills manually or with a dispenser system to provide enhanced functionality. The packages can be provided with information relating to the packaged pills or to the use of the packaged pills. By reading the information from the package, the dispenser system can know what is in the package, when it is to be taken and can understand and track inventory. The dispenser system provides reminders of when the pills should be taken. The dispenser system may have the ability to key a specific electronic device, such as a cell phone, to a specific user and the dispenser system may require the electronic device to be within proximity of the dispenser system before dispensing pills for that user.

Abstract: A medication administration tracker is provided. The medication administration tracker includes a medication container, such as an IV bag, vitamin organizer, prescription bottle and the like. If the present invention is a prescription bottle, a lid is releasably securable to the bottle. The present invention may include at least one indicator configured to produce an indication when prompted. A time keeper and a processor are integrated into the lid. The time keeper keeps time and the processor is operatively connected to the indicator and the time keeper. The processor is programmable to receive at least a dosage time and activate the indicator when the time keeper reaches the dosage time.

Abstract: A gastric feeding tube and method of use where the tube is of sufficient length for insertion into an esophagus of a subject via the nose or mouth. The gastric feed tube comprises a tube having a distal portion, a middle portion and a proximal portion, an outer surface and an inner surface forming a wall of the tube having a thickness and wherein the wall of the tube defines a lumen of a defined geometry, the lumen having an opening at a distal end of the tube for positioning in a stomach or jejunum of the subject and an opening at the proximal end of the tube for positioning outside of the nose or mouth of the subject wherein the lumen extends longitudinally through the tube connecting the opening at the distal end of the tube and the opening at the proximal end of the tube.

Abstract: A method of removing a dental adhesive may comprise locating the position of the dental adhesive, directing radiant energy into the dental adhesive causing the dental adhesive to weaken a bond formed with the dental adhesive, and breaking the bond by applying a suitable force to overcome the weakened bond. A dental adhesive may comprise a polymer and a dye or pigment, The dental adhesive may be formulated to cure to form a bond that is weakened in response to the dye or pigment absorbing radiant energy subsequent to curing.

Abstract: Methods and apparatus that permit a dentist to provide a patient with a monolithic ceramic dental restoration (e.g., crown, bridge, or the like) in one office visit. In some embodiments, a dentist is provided with a kit containing one or more near net shape (NNS) millable blanks of various shapes and shades, chair-side software, and a chair-side milling machine to convert a selected millable blank into a finished, fully contoured restoration in about one hour or less. Each such millable blank may be, for example, a dental ceramic (e.g., fully sintered zirconia, fully crystallized lithium silicate, fully crystallized lithium disilicate, or the like) NNS component. In some embodiments, the NNS component includes an integral mandrel at a precise location and orientation to minimize the amount of milling time.

Abstract: An object of the present invention is to provide a composition for external application that is applied to a part of the skin to more effectively elicit the useful effects of an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine, and that has long-lasting effects and enhanced skin-moisturizing effects. A gel composition for external application containing an adenine compound such as adenine, adenosine, and a phosphoric ester of adenosine is prepared by using agar as a gelling agent. The gel composition is further prepared in the form of a sheet-like adhesive patch. The gel composition in the form of a sheet-like adhesive patch is kept immersed in an aqueous solution containing the adenine compound.

Abstract: Slurry powder cosmetic composition comprising particulates coated with a binder composition, a silicone gel composition, and the evaporation residue of an alcohol based composition and a method for making the composition.

Abstract: A plate-like powder for cosmetics, powder is surface treated with a silicone gel, enhancing moldability and impact resistance of a solid powdery cosmetic composition as well as a solid powdery cosmetic composition. The surface-treated powder exhibits smooth and light touchiness, has moist usability, and excellent adhesion to skin. The surface-treated powder is blended into a powdery cosmetic composition, enhancing moldability and impact resistance of the composition and removed by an applicator.

Abstract: The invention is directed to the cosmetic powder surface-treated with a silicone gel, wherein the surface treatment with the silicone gel affords excellent water repellency, the exhibits smooth and light touch, and affords moist usability peculiar to the silicone gel and excellent adhesion to skin for the cosmetic powder. The powder is an inorganic powder, an organic powder or a composite powder thereof. The silicone gel is obtained by hydrolysis and condensation reacting an organopolysiloxane containing at least a diorganopolysiloxane having reactive opposite ends shown in the following formula (1) and a silane coupling agent having the following formula (2) with at least two hydrolyzable groups in one molecule or a reactive polysiloxane of the following formula (3) as a crosslinking agent. (1) R1R22SiO—(R22SiO)L—SiR1R22; (2) R3R4nSiX(3-n); and (3) R53SiO—(R52SiO)n-SiR53.

Abstract: A hydrogel-forming material for preparing hydrogel even after a process of stirring gelator in medium heat to dissolve and disperse the gelator, and cooling the mixture to room temperature with stirring, a hydrogel material wherein a gel can reform by standing at room temperature even after a hydrogel obtained using the material is converted sol by shaking. The hydrogel-forming material with lipid peptide gelator includes Formula (1) or a pharmaceutically usable salt thereof: R1 is a C9-23 aliphatic group, R2 is a hydrogen atom or C1-4 alkyl group optionally having a C1-2 branched chain, R3 is a —(CH2)n—X group, n is 1 to 4, and X is an amino-group, guanidino group, CONH2 group, 5-membered ring optionally having 1-3 nitrogen atom(s), 6-membered ring optionally having 1-3 nitrogen atom(s), or fused heterocycle composed of 5-membered ring and 6-membered rings optionally having 1-3 nitrogen atom(s), water, and fatty acid salt as additive.

Abstract: A cosmetic composition for topical application to skin is provided. The cosmetic composition includes vitamin B3 compound, a ricinoleate compound and a dermatologically acceptable carrier. The vitamin B3 compound and the ricinoleate beneficially or even synergistically up-regulate proteasomal protease activity as evidenced by a higher observed net luminescence value relative to the calculated net luminescence value in B16 melanoma cells.

Abstract: The invention relates to nail composition sets comprising at least one primer, at least one bonding composition, and at least one color coat, wherein the primer comprises water and at least one adhesive compound and preferably further comprises at least one water-soluble film forming agent and/or at least one plasticizer.

Abstract: Methods and kits for treating hair or preventing damage in the relaxing of hair are disclosed herein. Hair that is damaged during a relaxing treatment with hydroxide-containing relaxing agents, can be treated with formulations containing one or more active agents. The active agent formulations can be applied simultaneously with the hair relaxing formulation, or optionally applied immediately following application of the relaxing formulation, to reduce damage and breakage. Use of the active agent formulation along with a relaxing treatment can be used to control the level of curl achieved or retained in the relaxed hair, as compared to the natural amount of curl in the untreated hair.

Abstract: Peptides (and derivatives thereof), topical compositions, and methods of diminishing signs of aging and/or improving health of human integuments are provided. The peptides are derived from human Growth Differentiation Factor 11 (GDF-11).

Abstract: The present invention provides a novel gellant capable of favorably gelatinizing an oily base. The present invention relates to a gellant for an oily base, which contains the peptide compound represented by the formula (1), and further relates to a gelatinous composition containing (A) the gellant for an oily base, and (B) an oily base. Formula (1): wherein the symbols are as described in the DESCRIPTION.

Abstract: The invention solves the problem of the practical realization of an effective prophylactic composition which uses available and safe components and which can be recommended for preventing the growth of candidiasis of the skin and/or mucous membranes in humans in the following risk group: sufferers of diabetes mellitus, people with blood diseases, immune deficiency and other serious pathologies, patents after a course of hormone therapy, antibiotic treatment or chemotherapy, as well as for babies and pregnant women; and for people using tooth implants. The composition for the prophylaxis of candidiasis comprises active components, with the active components used being xylitol in a quantity of 0.3-20.0% by mass and sodium or potassium alginate or a mixture thereof in a quantity of 0.01-2.0% by mass, as well as inert components.

Abstract: The present invention relates to the use of a thiol-group-containing polymer for preparing an implant for tissue augmentation, wherein the basis polymer is a polysaccharide.

Abstract: Various compositions and methods are provided to alleviate one or more symptoms associated with hyposalivation and/or xerostomia. Preferred compositions and methods employ one or more plant pulp products and/or a proanthocyanidin at a concentration effective to reduce or eliminate the symptoms. Especially preferred product components are isolated from a fruit and/or seed (e.g., grape, cranberry, blue berry, black berry, etc.), and where a second component is is preferably a freeze-dried pulp from a citrus fruit (e.g., lemon, orange, lime, grapefruit, tangerine, mandarin orange, ugli fruit, etc.) not containing peel or juice therein.

Abstract: This application discloses an anti-aging composition for dermal application comprising cannabidiol hemp oil, chuanxiong extract, mondo grass extract, Chinese foxglove extract, female and panax ginseng extract, dragon's blood resin, lilyturf root, and jojoba oil. Other active ingredients may include licorice root, Astragalus membranceus, tree peony, mulberry bark extraction, longan fruit, wild pansy, rose canina seed powder, and Radix polygoni multiflori. The composition is formulated with other components to serve as a cleanser, a moisturizer, a serum, a gel masque, an eye cream, a toner, or an exfoliant.

Abstract: The invention provides cosmetic compositions comprising microalgal biomass, whole microalgal cells, and/or microalgal oil in combination with one or more other cosmetic ingredients, and methods of making such compositions. In preferred embodiments, the microalgal components of the cosmetic compositions are derived from microalgal cultures grown heterotrophically and which comprise at least 10% oil by dry weight.

Abstract: There is provided a formulation suitable for transmucosal administration comprising a short acting hypnotic drug, which formulation provides a measurable plasma concentration of drug within 10 minutes of administration. The formulation is capable of providing sleep on demand, and preferably comprises particles of drug, for example zolpidem or a pharmaceutically-acceptable salt thereof and a mucoadhesion promoting agent, such as sodium carboxymethylcellulose, which particles of drug and mucoadhesive are presented upon the surface of larger carrier particles.

Abstract: A composition for topical application characterized in that it includes, in a hydrogel base, vanillyl butyl ether and menthol. The composition described herein produces an ordered development of cold and warm sensations, obtaining effects that are particularly useful in the treatment of painful disorders of neurological and/or muscular origin. The composition has further moisturizing and soothing effects that concur to an effect that is also curative, i.e., not simply symptomatic, of rheumatic and muscular pain, trauma and bruises. The composition is compatible with each administration form, being preferably and advantageously formulated as a plaster.

Abstract: This invention provides an injectable formulation to be administered intramuscularly or subcutaneously that is used for the prevention or treatment of polycystic kidney disease, and that can maintain a therapeutically effective blood concentration of tolvaptan for a long period of time; and a process for producing the same. More specifically, this invention relates to an injectable depot formulation comprising (1) a particle containing optically active tolvaptan as an active ingredient and (2) a pharmaceutically acceptable carrier for injection, and a process for producing the same.

Abstract: Described herein are methods and pharmaceutical formulations for treating dry eye disease.

Abstract: The present invention relates to a chewable formulation for delivering a nutritional or pharmaceutically active agent to an animal target. The chewable formulation comprises a nutritional ingredient or an effective amount of a pharmaceutically active agent, and a plasticizer. The chewable formulation is formed by extrusion and the formulation contains substantially no unbound water, nor is any water added in the manufacturing process. The present invention also relates to a method of manufacturing a shelf stable chewable formulation which comprises mixing the nutritional or pharmaceutically active agent with a fat, lipid or fat and lipid to obtain a first composition, adding one or more plasticizers to the first mixture to obtain a second composition, extruding the second composition at a temperature sufficient to melt the fat and lipid, and allowing the extruded second composition to cool to room temperature thereby providing the chewable formulation.

Abstract: The present application relates to probiotic confection-based compositions comprising lactic acid-producing bacteria and oil-based compositions comprising the same.

Abstract: An edible oral film strip dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible oral film strip dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.

Abstract: The present invention provides methods for enhancing transmucosal uptake of a medicament, e.g., fentanyl or buprenorphine, to a subject and related devices. The method includes administering to a subject a transmucosal drug delivery device comprising the medicament. Also provided are devices suitable for transmucosal administration of a medicament to a subject and methods of their administration and use. The devices include a medicament disposed in a mucoadhesive polymeric diffusion environment and a barrier environment.

Abstract: A suspension which is suitable for oral administration, comprising simvastatin, at least one suspending agent, and at least one preservative, wherein at least 90 wt % of the particles of simvastatin are less than 100 ?m in diameter. The present invention also includes uses of the suspension and methods of making the suspension.

Abstract: Particle functionalization systems including one or more of: a target of a material; an energetic ion and/or electron source providing accelerated ions and electrons to the target; a potential that is applied to at least the target and that causes ions and/or electrons from the ionized gas to impact a surface of the target and release atoms of the material; at least one magnet providing a magnetic field that controls movement of the ions and electrons and nucleation, formation and growth of particles from the released atoms; and a particle collection device that collects particles, the collection device comprising a substrate and a polymeric functionalization coating disposed on the substrate, wherein particles impinge upon and form bonds with molecules of the functionalization coating. Methods of preparing functionalized particles, functionalized particle compositions, and kits including functionalized particles are also described.

Abstract: The present invention relates to an orally disintegrating tablet (ODT) containing asenapine maleate and to a process for preparing the ODT. In a first aspect, the present invention relates to an ODT containing asenapine maleate and low substituted hydroxypropylcellulose. In a second aspect, the present invention relates to an ODT containing crystalline asenapine maleate and the ODT is prepared using conventional tabletting techniques as direct compression and granulation. In a third aspect, the present invention relates to an ODT containing asenapine maleate and a carboxylic acid, and to the use of a carboxylic acid for enhancing storage stability of an asenapine maleate containing ODT.

Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclosed.

Abstract: The present invention provides a solid dosage form including an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein the inner coating includes a partially neutralized anionic polymeric material, and at least a carboxylic acid having 2 to 16 carbon atoms the salts thereof or mixtures of the acid and its salt; wherein the outer coating includes an anionic polymeric material which is less or not at all neutralized than the material of the inner coating.