Patents Issued in March 21, 2017
  • Patent number: 9598349
    Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Nicox Science Ireland
    Inventors: Nicoletta Almirante, Laura Storoni, Gael Ronsin, Elena Bastia
  • Patent number: 9598350
    Abstract: The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: March 21, 2017
    Assignee: Produits Chimiques Auxiliaries et de Synthese
    Inventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
  • Patent number: 9598351
    Abstract: Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: March 21, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Otto Phanstiel, IV
  • Patent number: 9598352
    Abstract: The present invention provides methods and devices for producing polyhedral boron compounds. The process is generally an anhydrous, one-pot process that comprises a pyrolytic reaction of a tetraborohydride with a quaternary amine salt to form the polyhedral borane. In another aspect of the present invention, polyhedral boranes are produced, without isolation of the Lewis base-borane complex.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: March 21, 2017
    Assignee: The Curators of the University of Missouri
    Inventors: Mark Wayne Lee, Marion Frederick Hawthorne
  • Patent number: 9598353
    Abstract: According to the present invention, a method is provided wherein a basic aqueous phase containing an optically active ?-amino acid is brought into contact with an organic phase containing a racemisation catalyst in the form of a copper metal complex of copper ions and an ?-amino acid and salicylaldehyde, in the presence of a phase transition catalyst, thereby subjecting the optically active ?-amino acid to racemisation. In the ?-amino acid racemisation method according to the present invention, the reaction conditions are mild and thus there is little ?-amino acid breakdown and the yield is high, the racemisation catalyst can be reused, the ?-amino acid resulting from the racemisation can easily be isolated and purified, and the racemisation method can be implemented in volume such that the invention is economic.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: March 21, 2017
    Assignee: Aminologics Co., Ltd.
    Inventors: Il Suk Byun, Kyu Sung Han, Hye Rim Ga
  • Patent number: 9598354
    Abstract: Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.
    Type: Grant
    Filed: May 3, 2015
    Date of Patent: March 21, 2017
    Inventor: Mark Quang Nguyen
  • Patent number: 9598355
    Abstract: The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: March 21, 2017
    Assignee: Intrexon Corporation
    Inventors: Robert Eugene Hormann, Bing Li
  • Patent number: 9598356
    Abstract: Cyhalofop is prepared by coupling 2-(4-hydroxyphenoxy)propionic acid and 3,4-difluorobenzonitrile with base in a polar aprotic solvent in the presence of a phase-transfer catalyst.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: March 21, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Ronald B. Leng, Eric W. Otterbacher, Herbert N. Praay
  • Patent number: 9598357
    Abstract: The present invention discloses a process and catalysts for producing taurine by catalytic ammonolysis of alkali ditaurinate, alkali tritaurinate, and their mixture. Useful catalysts are the ammonium and alkali salts of sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, nitrate, phosphate, and organic carboxylic acids.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: March 21, 2017
    Assignee: VITAWORKS IP, LLC
    Inventor: Songzhou Hu
  • Patent number: 9598358
    Abstract: Acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates under esterification reaction conditions. The alkyl-substituted hydroxyalkyl sulfonates used as a raw material in producing the esters are prepared by reacting bisulfate with one or more alkylene oxides. The acylalkylisethionate esters may be used in consumer products.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: March 21, 2017
    Assignee: HUNTSMAN PETROCHEMICAL LLC
    Inventors: Prakasa R. Anantaneni, John Gray, Marty J. Renner, George A. Smith, David C. Lewis, Donald H. Champion, Christopher J. Whewell
  • Patent number: 9598359
    Abstract: Sulfonate compositions are disclosed. The compositions include alkanesulfonates, alkenesulfonates, sultones, and hydroxy-substituted alkanesulfonates. The sulfonates comprise a reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with a sulfonating or sulfitating agent. In one aspect, the sulfonate composition is a sulfo-estolide made by reacting a metathesis-derived C10-C17 monounsaturated acid or octadecene-1,18-dioic acid with a sulfonating agent, optionally in the presence of a saturated fatty acid. The sulfonates are valuable for a wide variety of end uses, including cleaners, fabric treatment, hair conditioning, personal care (liquid cleansing products, conditioning bars, oral care products), paint additives, antimicrobial compositions, agricultural uses, and oil field applications.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: March 21, 2017
    Assignee: Stepan Company
    Inventors: Dave R. Allen, Randal J. Bernhardt, Aaron Brown, Gary Luebke, Renee Luka, Andrew D. Malec, Ronald A. Masters, Patti Skelton, Brian Sook, Jeremy Aaron Weitgenant, Patrick Shane Wolfe
  • Patent number: 9598360
    Abstract: A cyclic process is disclosed for the production of taurine from alkali vinyl sulfonate in a high overall yield by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. Sodium sulfate and residual taurine in the crystallization mother liquor are efficiently separated by converting taurine into a highly soluble form of sodium taurinate or ammonium taurinate while selectively crystallizing sodium sulfate.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 21, 2017
    Assignee: VITAWORKS IP, LLC
    Inventor: Songzhou Hu
  • Patent number: 9598361
    Abstract: An amino substituted acetamide derivative can include a compound having the following general formula: wherein R represents (4-Cyano-4-phenyl)piperidinyl hydrochloride, (4-Hydroxy-4-phenyl)piperidine, (4-chlorophenyl)piperidine hydrochloride, 4-Piperidinopiperidine, 4-(Methoxyphenyl)piperidine, 1-(2,3-xylyl)piperazine monohydrochloride, 4-Aminoquinaldine or anthranilic acid, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: March 21, 2017
    Assignee: KING SAUD UNIVERSITY
    Inventors: Amani Shafeek Awaad, Ahmed Mahmoud Ahmed Alafeefy, Reham Mostafa El-Meligy
  • Patent number: 9598362
    Abstract: The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: March 21, 2017
    Assignees: Seoul National University R&DB Foundation, POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Sung Key Jang, Byeong Moon Kim, Il Hak Bae, Jin Kyu Choi, Sun Ju Keum, Seung Gi Lee, Hee Sun Kim
  • Patent number: 9598363
    Abstract: The present invention relates to novel strigolactam derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants and/or promoting the germination of seeds.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: March 21, 2017
    Assignee: Syngenta Participations AG
    Inventors: Mathilde Denise Lachia, Alain De Mesmaeker, Claudio Screpanti, Hanno Christian Wolf, Pierre Joseph Marcel Jung
  • Patent number: 9598364
    Abstract: Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: March 21, 2017
    Assignees: Taipei Medical University, Ohio State University, National Taiwan University
    Inventors: Ching-Shih Chen, Jing-Ping Liou, Hsing-Jin Liu, Kuo-Sheng Hung, Pei-Wen Shan, Wen-Ta Chiu, Che-Ming Teng
  • Patent number: 9598365
    Abstract: A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In(III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-1 or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: March 21, 2017
    Assignee: TRUSTEES OF DARTMOUTH COLLEGE
    Inventor: Jimmy Wu
  • Patent number: 9598366
    Abstract: A process for increasing the overall yield of pyridine or its alkyl pyridine derivatives during a base synthesis reaction is disclosed. The process comprises reacting a C2 to C5 aldehyde, a C3 to C5 ketone or a combination thereof, with ammonia and, optionally, formaldehyde, in the gas phase and in the presence of an effective amount of a particulate catalyst comprising a zeolite, zinc, a binder, and clay and optionally a matrix, wherein the catalyst has a L/B ratio of about 1.5 to about 4.0. Preferably, the zeolite is ZSM-5. A process for enhancing the catalytic activity of a zinc and zeolite containing catalyst to increase the overall yield of pyridine and/or its derivatives during a base synthesis reaction is also disclosed.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: March 21, 2017
    Assignee: W. R. GRACE & CO.-CONN.
    Inventor: Dorai Ramprasad
  • Patent number: 9598367
    Abstract: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: March 21, 2017
    Assignee: Zenith Epigenetics Ltd.
    Inventors: Shuang Liu, Bryan Cordell Duffy, John Frederick Quinn, May Xiaowu Jiang, Ruifang Wang, Gregory Scott Martin, He Zhao, Bruce Francis Molino, Peter Ronald Young
  • Patent number: 9598368
    Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, reaction with hydrazine, halogenation, hydrolysis and esterification, and transition metal assisted coupling.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: March 21, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Yuanming Zhu, Gregory T. Whiteker, Cynthia Arndt, James M. Renga, Robert D. J. Froese
  • Patent number: 9598369
    Abstract: The present invention provides a novel and improved process for the production of the production of hindered anilines containing perfluoroalky groups in good yield any by using close to stoichiometric amounts of acylating agent.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: March 21, 2017
    Assignee: Syngenta Participations AG
    Inventors: Helmars Smits, Thomas Pitterna, Ottmar Franz Hueter, Andrew Edmunds, Andre Stoller, Pierre Joseph Marcel Jung
  • Patent number: 9598370
    Abstract: The present disclosure relates to HIF-1? prolyl hydroxylase inhibitors, compositions which comprise the HIF-1? prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: March 21, 2017
    Assignee: Akebia Therapeutics, Inc.
    Inventors: Richard Masaru Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon
  • Patent number: 9598371
    Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: March 21, 2017
    Assignee: LUPIN ATLANTIS HOLDINGS SA
    Inventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
  • Patent number: 9598372
    Abstract: The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: March 21, 2017
    Assignee: Celgene Quanticel Research, Inc.
    Inventor: Amogh Boloor
  • Patent number: 9598373
    Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: March 21, 2017
    Assignee: TACURION
    Inventors: Souichirou Kawazoe, Takahiro Akiba, Kiichi Sato, Akio Miyafuji, Kazuyoshi Obitsu, Junji Itoh, Shun Hirasawa, Hiroyuki Koshio
  • Patent number: 9598374
    Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 21, 2017
    Assignee: Epizyme, Inc.
    Inventors: Richard Chesworth, Lorna Helen Mitchell, Gideon Shapiro, Kerren Kalai Swinger
  • Patent number: 9598375
    Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. and their use in the treatment of diseases such as Alzheimer's Disease.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: March 21, 2017
    Assignee: vTv Therapeutics LLC
    Inventors: David Jones, Raju Bore Gowda, Rongyuan Xie
  • Patent number: 9598376
    Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
    Type: Grant
    Filed: February 25, 2016
    Date of Patent: March 21, 2017
    Assignees: Array BioPharma, Inc., Novartis AG
    Inventors: Christoph Max Krell, Marian Misun, Daniel Andreas Niederer, Werner Heinz Pachinger, Marie-Christine Wolf, Daniel Zimmermann, Weidong Liu, Peter J. Stengel, Paul Nichols
  • Patent number: 9598377
    Abstract: The present invention is directed to particles prepared via the polymerization of at least one surfactant and an isocyanate-containing compound. Pharmaceutical compositions prepared using these particles are also described.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: March 21, 2017
    Assignee: Cephalon, Inc.
    Inventors: Peter D. Brown, Anthony S. Drager
  • Patent number: 9598378
    Abstract: This invention relates to 2-aminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: March 21, 2017
    Assignee: Janssen Sciences Ireland UC
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Tim Hugo Maria Jonckers
  • Patent number: 9598379
    Abstract: Process for preparing melamine by converting urea in the presence of a solid catalyst in one reactor or in a plurality of reactors connected in series in the temperature range from 370° C. to 430° C., cooling and filtering the gas formed in the urea conversion, removing the melamine by desublimation and recycling a portion of the gas present after the melamine removal (“cycle gas”) into the reactor or the reactors, which comprises performing all of the above stages at a pressure in the range from 4 bar abs. to 10 bar abs.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: March 21, 2017
    Assignee: BASF SE
    Inventors: Andreas Kern, Hans-Ulrich Pröbstle, Tilo John, Wolfgang Steiner, Heiko Maas
  • Patent number: 9598380
    Abstract: Described are methods for preparing salts of 5-nitrotetrazolate by reacting 5-aminotetrazole, an acid, and sodium nitrite in water in a batch reaction at an elevated temperature. As examples, the acid is nitric acid, sulfuric acid, perchloric acid, or hydrochloric acid, and the elevated temperature is at or above 65° C.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: March 21, 2017
    Assignees: SRI International, Pacific Scientific Energetic Materials Company, LLC
    Inventors: Jeffrey C. Bottaro, Mark A. Petrie, Jon G. Bragg, John W. Fronabarger, Michael D. Williams
  • Patent number: 9598381
    Abstract: The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: March 21, 2017
    Assignee: AbbVie Inc.
    Inventors: Gary G. Chiang, William N. Pappano, Ramzi F. Sweis, Zhi Wang
  • Patent number: 9598382
    Abstract: A method for producing a purified compound represented by the formula (II), comprising; obtaining a reaction mixture containing a compound represented by the formula (I) from a crude compound represented by the formula (II) such as reacting the crude compound with a ketone compound, and reacting the obtained reaction mixture or a solution by filtering thus obtained reaction mixture containing the compound represented by the formula (I) with water.
    Type: Grant
    Filed: December 25, 2014
    Date of Patent: March 21, 2017
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tadafumi Matsunaga, Hiromi Kaise
  • Patent number: 9598383
    Abstract: Provided herein are ROS-sensitive prodrug compositions and methods of treating ROS-associated diseases by administering the ROS-sensitive prodrug compositions.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: March 21, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Seth M. Cohen, Jean-Philippe Monserrat, Christian Perez
  • Patent number: 9598384
    Abstract: 3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-3-alkylidene-1,3-dihydro-indol-2-one and derivatives thereof are provided for use as selective SphK2 inhibitors and for use in the treatment of human diseases, such as cancer.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: March 21, 2017
    Assignee: Virginia Commonwealth University
    Inventors: Shijun Zhang, Sarah Spiegel
  • Patent number: 9598385
    Abstract: Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: March 21, 2017
    Assignee: CITY OF HOPE
    Inventors: David Horne, Christopher Lincoln
  • Patent number: 9598386
    Abstract: This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: March 21, 2017
    Assignees: University of Strathclyde, University of Glasgow
    Inventors: Margaret Harnett, William Harnett, Colin J. Suckling, Fraser Scott, Judith K. Huggan, Abedawn I. Khalaf
  • Patent number: 9598387
    Abstract: Provided are compounds represented by the formula: with Y, Ri, and R2 being defined in the present disclosure; pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors and are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: March 21, 2017
    Assignee: Southern Research Institute
    Inventor: Subramaniam Ananthan
  • Patent number: 9598388
    Abstract: The present invention is concerned with a method for producing tetrahydrofuran including carrying out a dehydration cyclization reaction of 1,4-butanediol in the presence of an acid catalyst having a pKa value of not more than 4 within a reactor, wherein a raw material liquid containing 1,4-butanediol to be provided for the reaction contains from 0.01 to 0.35% by weight of 2-(4-hydroxybutoxy)-tetrahydrofuran and 1 ppm by weight or more and not more than 1,000 ppm by weight of at least one of an amine and an amide in terms of a concentration as converted into a nitrogen atom.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 21, 2017
    Assignee: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Yusuke Izawa, Masaru Utsunomiya, Norikazu Konishi, Kouta Tanaka
  • Patent number: 9598389
    Abstract: Provided are compounds of formula (I) and methods of controlling insects, acarines, nematodes or molluscs, which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: March 21, 2017
    Assignee: Syngenta Participations AG
    Inventors: Long Lu, Jerome Yves Cassayre, Torsten Luksch, Myriem El Qacemi, Guillaume Berthon, Yaming Wu
  • Patent number: 9598390
    Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 21, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yan Shi, Hao Zhang, Peter T. W. Cheng, Shiwei Tao
  • Patent number: 9598391
    Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: March 21, 2017
    Assignee: Lupin Atlantis Holdings SA
    Inventors: Manojkumar Ramprasad Shukla, Ankush Gangaram Sarde, Rajeshkumar Maganlal Loriya, Vipul Dilip Pachpute, Navnath Bajirao Walke, Talha Hussain Khan, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
  • Patent number: 9598392
    Abstract: A resist composition containing a compound represented by the general formula (1) or (2), a method for forming a resist pattern using the composition, a polyphenolic compound for use in the composition, and an alcoholic compound that can be derived therefrom are described.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: March 21, 2017
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Masatoshi Echigo, Masako Yamakawa
  • Patent number: 9598393
    Abstract: The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y—O—W (I), wherein Y and W are as defined in claim 1.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: March 21, 2017
    Assignee: Institut Pasteur
    Inventors: Caroline Demangel, Nicolas Blanchard, Georges Bismuth, Jacques Eustache, Virginie Casarotto, Anne-Caroline Chany, Laure Guenin-Mace
  • Patent number: 9598394
    Abstract: Disclosed is a method of producing trioxane, including: (A) preparing trioxane from a high-concentration formaldehyde aqueous solution in the presence of an acid catalyst; (B) distilling a mixture including trioxane; (C) liquefying the distilled gas mixture; (D) mixing the liquefied liquid mixture with an extraction solvent and separating the mixture into an aqueous phase and a solvent phase; (E) distilling the solvent phase to give trioxane, and mixing the aqueous phase with the extraction solvent to give a mixture, which is then separated into an aqueous phase and a solvent phase; and (F) discharging the aqueous phase separated in (E) out of the system, and recirculating the solvent phase so as to be reused in (D) and (E).
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: March 21, 2017
    Inventor: Sung Yong Baek
  • Patent number: 9598395
    Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: March 21, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Richard A. Gatti, Liutao Du, Hailiang Hu, Robert Damoiseaux, Michael E. Jung, Jin-Mo Ku, Gladys Completo
  • Patent number: 9598396
    Abstract: The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: March 21, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Patrick Rene Angibaud, Laurence Anne Mevellec, Bruno Roux, Pierre-Henri Storck, Christophe Meyer, Jorge Eduardo Vialard
  • Patent number: 9598397
    Abstract: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: March 21, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Yang Cao, Donald R. Gauthier, Jr., Guy R. Humphrey, Tetsuji Itoh, Michel Journet, Gang Qian, Benjamin D. Sherry, David M. Tschaen
  • Patent number: 9598398
    Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: March 21, 2017
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Tatsuki Koike, Masato Yoshikawa, Haruhi Ando, William John Farnaby, Shuhei Ikeda, Yuichi Kajita, Toshiya Nishi