Patents Issued in March 21, 2017
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Patent number: 9598349Abstract: The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.Type: GrantFiled: April 14, 2014Date of Patent: March 21, 2017Assignee: Nicox Science IrelandInventors: Nicoletta Almirante, Laura Storoni, Gael Ronsin, Elena Bastia
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Patent number: 9598350Abstract: The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.Type: GrantFiled: March 21, 2016Date of Patent: March 21, 2017Assignee: Produits Chimiques Auxiliaries et de SyntheseInventors: Jean-Marie Schneider, Jonathan Madec, Sergio Kreimerman, Gerard Guillamot
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Patent number: 9598351Abstract: Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.Type: GrantFiled: September 23, 2015Date of Patent: March 21, 2017Assignee: University of Central Florida Research Foundation, Inc.Inventor: Otto Phanstiel, IV
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Patent number: 9598352Abstract: The present invention provides methods and devices for producing polyhedral boron compounds. The process is generally an anhydrous, one-pot process that comprises a pyrolytic reaction of a tetraborohydride with a quaternary amine salt to form the polyhedral borane. In another aspect of the present invention, polyhedral boranes are produced, without isolation of the Lewis base-borane complex.Type: GrantFiled: November 16, 2012Date of Patent: March 21, 2017Assignee: The Curators of the University of MissouriInventors: Mark Wayne Lee, Marion Frederick Hawthorne
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Patent number: 9598353Abstract: According to the present invention, a method is provided wherein a basic aqueous phase containing an optically active ?-amino acid is brought into contact with an organic phase containing a racemisation catalyst in the form of a copper metal complex of copper ions and an ?-amino acid and salicylaldehyde, in the presence of a phase transition catalyst, thereby subjecting the optically active ?-amino acid to racemisation. In the ?-amino acid racemisation method according to the present invention, the reaction conditions are mild and thus there is little ?-amino acid breakdown and the yield is high, the racemisation catalyst can be reused, the ?-amino acid resulting from the racemisation can easily be isolated and purified, and the racemisation method can be implemented in volume such that the invention is economic.Type: GrantFiled: August 7, 2014Date of Patent: March 21, 2017Assignee: Aminologics Co., Ltd.Inventors: Il Suk Byun, Kyu Sung Han, Hye Rim Ga
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Patent number: 9598354Abstract: Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed.Type: GrantFiled: May 3, 2015Date of Patent: March 21, 2017Inventor: Mark Quang Nguyen
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Patent number: 9598355Abstract: The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.Type: GrantFiled: October 9, 2014Date of Patent: March 21, 2017Assignee: Intrexon CorporationInventors: Robert Eugene Hormann, Bing Li
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Patent number: 9598356Abstract: Cyhalofop is prepared by coupling 2-(4-hydroxyphenoxy)propionic acid and 3,4-difluorobenzonitrile with base in a polar aprotic solvent in the presence of a phase-transfer catalyst.Type: GrantFiled: February 24, 2011Date of Patent: March 21, 2017Assignee: Dow AgroSciences LLCInventors: Ronald B. Leng, Eric W. Otterbacher, Herbert N. Praay
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Patent number: 9598357Abstract: The present invention discloses a process and catalysts for producing taurine by catalytic ammonolysis of alkali ditaurinate, alkali tritaurinate, and their mixture. Useful catalysts are the ammonium and alkali salts of sulfate, bisulfate, sulfite, bisulfite, carbonate, bicarbonate, nitrate, phosphate, and organic carboxylic acids.Type: GrantFiled: February 29, 2016Date of Patent: March 21, 2017Assignee: VITAWORKS IP, LLCInventor: Songzhou Hu
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Patent number: 9598358Abstract: Acylalkylisethionate esters are produced by reacting one or more carboxylic acids with one or more alkyl-substituted hydroxyalkyl sulfonates under esterification reaction conditions. The alkyl-substituted hydroxyalkyl sulfonates used as a raw material in producing the esters are prepared by reacting bisulfate with one or more alkylene oxides. The acylalkylisethionate esters may be used in consumer products.Type: GrantFiled: June 28, 2011Date of Patent: March 21, 2017Assignee: HUNTSMAN PETROCHEMICAL LLCInventors: Prakasa R. Anantaneni, John Gray, Marty J. Renner, George A. Smith, David C. Lewis, Donald H. Champion, Christopher J. Whewell
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Patent number: 9598359Abstract: Sulfonate compositions are disclosed. The compositions include alkanesulfonates, alkenesulfonates, sultones, and hydroxy-substituted alkanesulfonates. The sulfonates comprise a reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives with a sulfonating or sulfitating agent. In one aspect, the sulfonate composition is a sulfo-estolide made by reacting a metathesis-derived C10-C17 monounsaturated acid or octadecene-1,18-dioic acid with a sulfonating agent, optionally in the presence of a saturated fatty acid. The sulfonates are valuable for a wide variety of end uses, including cleaners, fabric treatment, hair conditioning, personal care (liquid cleansing products, conditioning bars, oral care products), paint additives, antimicrobial compositions, agricultural uses, and oil field applications.Type: GrantFiled: October 25, 2011Date of Patent: March 21, 2017Assignee: Stepan CompanyInventors: Dave R. Allen, Randal J. Bernhardt, Aaron Brown, Gary Luebke, Renee Luka, Andrew D. Malec, Ronald A. Masters, Patti Skelton, Brian Sook, Jeremy Aaron Weitgenant, Patrick Shane Wolfe
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Patent number: 9598360Abstract: A cyclic process is disclosed for the production of taurine from alkali vinyl sulfonate in a high overall yield by continuously converting the byproducts of the ammonolysis reaction, sodium ditaurinate and sodium tritaurinate, to sodium taurinate. Sodium sulfate and residual taurine in the crystallization mother liquor are efficiently separated by converting taurine into a highly soluble form of sodium taurinate or ammonium taurinate while selectively crystallizing sodium sulfate.Type: GrantFiled: August 4, 2016Date of Patent: March 21, 2017Assignee: VITAWORKS IP, LLCInventor: Songzhou Hu
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Patent number: 9598361Abstract: An amino substituted acetamide derivative can include a compound having the following general formula: wherein R represents (4-Cyano-4-phenyl)piperidinyl hydrochloride, (4-Hydroxy-4-phenyl)piperidine, (4-chlorophenyl)piperidine hydrochloride, 4-Piperidinopiperidine, 4-(Methoxyphenyl)piperidine, 1-(2,3-xylyl)piperazine monohydrochloride, 4-Aminoquinaldine or anthranilic acid, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 12, 2016Date of Patent: March 21, 2017Assignee: KING SAUD UNIVERSITYInventors: Amani Shafeek Awaad, Ahmed Mahmoud Ahmed Alafeefy, Reham Mostafa El-Meligy
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Patent number: 9598362Abstract: The disclosed compounds have antiviral activity against C-type virus, an optical isomer thereof, a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating liver disease caused by hepatitis C virus. The benzidine derivative according to the present invention has excellent antiviral activity against hepatitis C virus and exhibits excellent medicinal activity in the living body, and thus the pharmaceutical composition containing the same as an active ingredient can be useful as a pharmaceutical composition for preventing or treating liver disease, such as acute hepatitis C, chronic hepatitis C, cirrhosis, or hepatocellular carcinoma, caused by C-type virus.Type: GrantFiled: October 15, 2015Date of Patent: March 21, 2017Assignees: Seoul National University R&DB Foundation, POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sung Key Jang, Byeong Moon Kim, Il Hak Bae, Jin Kyu Choi, Sun Ju Keum, Seung Gi Lee, Hee Sun Kim
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Patent number: 9598363Abstract: The present invention relates to novel strigolactam derivatives, to processes and intermediates for preparing them, to plant growth regulator compositions comprising them and to methods of using them for controlling the growth of plants and/or promoting the germination of seeds.Type: GrantFiled: February 27, 2014Date of Patent: March 21, 2017Assignee: Syngenta Participations AGInventors: Mathilde Denise Lachia, Alain De Mesmaeker, Claudio Screpanti, Hanno Christian Wolf, Pierre Joseph Marcel Jung
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Patent number: 9598364Abstract: Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.Type: GrantFiled: August 26, 2014Date of Patent: March 21, 2017Assignees: Taipei Medical University, Ohio State University, National Taiwan UniversityInventors: Ching-Shih Chen, Jing-Ping Liou, Hsing-Jin Liu, Kuo-Sheng Hung, Pei-Wen Shan, Wen-Ta Chiu, Che-Ming Teng
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Patent number: 9598365Abstract: A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that combines (1) an indole, benzofuran, or benzothiopene, (2) an aldehyde, ketone, or ketal, and (3) a diene in the presence of an acid, in particular a Ga(III) or In(III) salt. Compositions and methods of using these compounds to stimulate secretion and/or production of glucagon-like peptide-1 or inhibit the activity of Calcitonin Gene-Related Peptide receptor are also provided.Type: GrantFiled: November 10, 2014Date of Patent: March 21, 2017Assignee: TRUSTEES OF DARTMOUTH COLLEGEInventor: Jimmy Wu
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Patent number: 9598366Abstract: A process for increasing the overall yield of pyridine or its alkyl pyridine derivatives during a base synthesis reaction is disclosed. The process comprises reacting a C2 to C5 aldehyde, a C3 to C5 ketone or a combination thereof, with ammonia and, optionally, formaldehyde, in the gas phase and in the presence of an effective amount of a particulate catalyst comprising a zeolite, zinc, a binder, and clay and optionally a matrix, wherein the catalyst has a L/B ratio of about 1.5 to about 4.0. Preferably, the zeolite is ZSM-5. A process for enhancing the catalytic activity of a zinc and zeolite containing catalyst to increase the overall yield of pyridine and/or its derivatives during a base synthesis reaction is also disclosed.Type: GrantFiled: October 24, 2013Date of Patent: March 21, 2017Assignee: W. R. GRACE & CO.-CONN.Inventor: Dorai Ramprasad
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Patent number: 9598367Abstract: The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.Type: GrantFiled: January 15, 2016Date of Patent: March 21, 2017Assignee: Zenith Epigenetics Ltd.Inventors: Shuang Liu, Bryan Cordell Duffy, John Frederick Quinn, May Xiaowu Jiang, Ruifang Wang, Gregory Scott Martin, He Zhao, Bruce Francis Molino, Peter Ronald Young
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Patent number: 9598368Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted)picolinates are conveniently prepared from 3,4,5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, reaction with hydrazine, halogenation, hydrolysis and esterification, and transition metal assisted coupling.Type: GrantFiled: October 9, 2013Date of Patent: March 21, 2017Assignee: Dow AgroSciences LLCInventors: Yuanming Zhu, Gregory T. Whiteker, Cynthia Arndt, James M. Renga, Robert D. J. Froese
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Patent number: 9598369Abstract: The present invention provides a novel and improved process for the production of the production of hindered anilines containing perfluoroalky groups in good yield any by using close to stoichiometric amounts of acylating agent.Type: GrantFiled: April 1, 2014Date of Patent: March 21, 2017Assignee: Syngenta Participations AGInventors: Helmars Smits, Thomas Pitterna, Ottmar Franz Hueter, Andrew Edmunds, Andre Stoller, Pierre Joseph Marcel Jung
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Patent number: 9598370Abstract: The present disclosure relates to HIF-1? prolyl hydroxylase inhibitors, compositions which comprise the HIF-1? prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.Type: GrantFiled: September 15, 2015Date of Patent: March 21, 2017Assignee: Akebia Therapeutics, Inc.Inventors: Richard Masaru Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon
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Patent number: 9598371Abstract: The present invention provides arylalkylamine compounds as calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: November 25, 2015Date of Patent: March 21, 2017Assignee: LUPIN ATLANTIS HOLDINGS SAInventors: Manojkumar Ramprasad Shukla, Vinod Dinkar Chaudhari, Ankush Gangaram Sarde, Ramesh Dattatraya Phadtare, Mahadeo Bhaskar Tryambake, Dronamraju Prameela, Sanjeev Kulkarni, Rajender Kumar Kamboj, Venkata P. Palle
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Patent number: 9598372Abstract: The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.Type: GrantFiled: July 1, 2015Date of Patent: March 21, 2017Assignee: Celgene Quanticel Research, Inc.Inventor: Amogh Boloor
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Patent number: 9598373Abstract: The present invention provides a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has an superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the methods. The production method of the present invention is suitable for the industrial production of a medicament, because of a smaller number of steps, a higher yield, and a lower cost, as compared with the methods in the related art.Type: GrantFiled: June 11, 2013Date of Patent: March 21, 2017Assignee: TACURIONInventors: Souichirou Kawazoe, Takahiro Akiba, Kiichi Sato, Akio Miyafuji, Kazuyoshi Obitsu, Junji Itoh, Shun Hirasawa, Hiroyuki Koshio
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Patent number: 9598374Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.Type: GrantFiled: March 14, 2014Date of Patent: March 21, 2017Assignee: Epizyme, Inc.Inventors: Richard Chesworth, Lorna Helen Mitchell, Gideon Shapiro, Kerren Kalai Swinger
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Patent number: 9598375Abstract: The present invention provides imidazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof. and their use in the treatment of diseases such as Alzheimer's Disease.Type: GrantFiled: October 9, 2013Date of Patent: March 21, 2017Assignee: vTv Therapeutics LLCInventors: David Jones, Raju Bore Gowda, Rongyuan Xie
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Patent number: 9598376Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.Type: GrantFiled: February 25, 2016Date of Patent: March 21, 2017Assignees: Array BioPharma, Inc., Novartis AGInventors: Christoph Max Krell, Marian Misun, Daniel Andreas Niederer, Werner Heinz Pachinger, Marie-Christine Wolf, Daniel Zimmermann, Weidong Liu, Peter J. Stengel, Paul Nichols
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Patent number: 9598377Abstract: The present invention is directed to particles prepared via the polymerization of at least one surfactant and an isocyanate-containing compound. Pharmaceutical compositions prepared using these particles are also described.Type: GrantFiled: March 12, 2014Date of Patent: March 21, 2017Assignee: Cephalon, Inc.Inventors: Peter D. Brown, Anthony S. Drager
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Patent number: 9598378Abstract: This invention relates to 2-aminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.Type: GrantFiled: February 20, 2014Date of Patent: March 21, 2017Assignee: Janssen Sciences Ireland UCInventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Tim Hugo Maria Jonckers
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Patent number: 9598379Abstract: Process for preparing melamine by converting urea in the presence of a solid catalyst in one reactor or in a plurality of reactors connected in series in the temperature range from 370° C. to 430° C., cooling and filtering the gas formed in the urea conversion, removing the melamine by desublimation and recycling a portion of the gas present after the melamine removal (“cycle gas”) into the reactor or the reactors, which comprises performing all of the above stages at a pressure in the range from 4 bar abs. to 10 bar abs.Type: GrantFiled: October 14, 2008Date of Patent: March 21, 2017Assignee: BASF SEInventors: Andreas Kern, Hans-Ulrich Pröbstle, Tilo John, Wolfgang Steiner, Heiko Maas
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Patent number: 9598380Abstract: Described are methods for preparing salts of 5-nitrotetrazolate by reacting 5-aminotetrazole, an acid, and sodium nitrite in water in a batch reaction at an elevated temperature. As examples, the acid is nitric acid, sulfuric acid, perchloric acid, or hydrochloric acid, and the elevated temperature is at or above 65° C.Type: GrantFiled: June 5, 2015Date of Patent: March 21, 2017Assignees: SRI International, Pacific Scientific Energetic Materials Company, LLCInventors: Jeffrey C. Bottaro, Mark A. Petrie, Jon G. Bragg, John W. Fronabarger, Michael D. Williams
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Patent number: 9598381Abstract: The present disclosure generally relates to compounds having cellular anti-proliferative activities, and more particularly relates to compounds which inhibit the activity of human SMYD2, a SET and MYND domain-containing protein lysine methyltransferase.Type: GrantFiled: July 29, 2015Date of Patent: March 21, 2017Assignee: AbbVie Inc.Inventors: Gary G. Chiang, William N. Pappano, Ramzi F. Sweis, Zhi Wang
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Patent number: 9598382Abstract: A method for producing a purified compound represented by the formula (II), comprising; obtaining a reaction mixture containing a compound represented by the formula (I) from a crude compound represented by the formula (II) such as reacting the crude compound with a ketone compound, and reacting the obtained reaction mixture or a solution by filtering thus obtained reaction mixture containing the compound represented by the formula (I) with water.Type: GrantFiled: December 25, 2014Date of Patent: March 21, 2017Assignee: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Tadafumi Matsunaga, Hiromi Kaise
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Patent number: 9598383Abstract: Provided herein are ROS-sensitive prodrug compositions and methods of treating ROS-associated diseases by administering the ROS-sensitive prodrug compositions.Type: GrantFiled: June 26, 2014Date of Patent: March 21, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Seth M. Cohen, Jean-Philippe Monserrat, Christian Perez
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Patent number: 9598384Abstract: 3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-thiazolidine-2,4-dione and 1-(2-amino-ethyl)-3-alkylidene-1,3-dihydro-indol-2-one and derivatives thereof are provided for use as selective SphK2 inhibitors and for use in the treatment of human diseases, such as cancer.Type: GrantFiled: November 5, 2015Date of Patent: March 21, 2017Assignee: Virginia Commonwealth UniversityInventors: Shijun Zhang, Sarah Spiegel
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Patent number: 9598385Abstract: Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme, as well as methods of synthesizing these novel compounds. The compounds may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.Type: GrantFiled: June 29, 2015Date of Patent: March 21, 2017Assignee: CITY OF HOPEInventors: David Horne, Christopher Lincoln
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Patent number: 9598386Abstract: This invention relates to compounds and uses thereof in the treatment or prophylaxis of diseases associated with inflammation.Type: GrantFiled: July 25, 2013Date of Patent: March 21, 2017Assignees: University of Strathclyde, University of GlasgowInventors: Margaret Harnett, William Harnett, Colin J. Suckling, Fraser Scott, Judith K. Huggan, Abedawn I. Khalaf
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Patent number: 9598387Abstract: Provided are compounds represented by the formula: with Y, Ri, and R2 being defined in the present disclosure; pharmaceutically acceptable salts thereof, deuterated forms thereof, isomers thereof, solvates thereof, and mixtures thereof. The compounds can be used for treating a patient suffering from a condition capable of treatment with a partial agonist or antagonist of the dopamine D2/D3 receptors and are especially useful for patients suffering from schizophrenia, depressions, neurodegenerative diseases such as Parkinson's, dyskinesias, substance abuse and relapse to substance abuse and addiction to substances such as cocaine, methamphetamine, nicotine and alcohol, glaucoma, cognitive disorders, restless leg syndrome, attention deficit hyperactivity disorders, hyperprolactinemia, autism, motor disturbances such as akathisia, rigor, dystonias as well as various disorders of the urinary tract and other neurologic disorders.Type: GrantFiled: October 11, 2013Date of Patent: March 21, 2017Assignee: Southern Research InstituteInventor: Subramaniam Ananthan
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Patent number: 9598388Abstract: The present invention is concerned with a method for producing tetrahydrofuran including carrying out a dehydration cyclization reaction of 1,4-butanediol in the presence of an acid catalyst having a pKa value of not more than 4 within a reactor, wherein a raw material liquid containing 1,4-butanediol to be provided for the reaction contains from 0.01 to 0.35% by weight of 2-(4-hydroxybutoxy)-tetrahydrofuran and 1 ppm by weight or more and not more than 1,000 ppm by weight of at least one of an amine and an amide in terms of a concentration as converted into a nitrogen atom.Type: GrantFiled: January 6, 2014Date of Patent: March 21, 2017Assignee: MITSUBISHI CHEMICAL CORPORATIONInventors: Yusuke Izawa, Masaru Utsunomiya, Norikazu Konishi, Kouta Tanaka
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Patent number: 9598389Abstract: Provided are compounds of formula (I) and methods of controlling insects, acarines, nematodes or molluscs, which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I).Type: GrantFiled: March 6, 2014Date of Patent: March 21, 2017Assignee: Syngenta Participations AGInventors: Long Lu, Jerome Yves Cassayre, Torsten Luksch, Myriem El Qacemi, Guillaume Berthon, Yaming Wu
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Patent number: 9598390Abstract: The present invention provides compounds of Formula (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.Type: GrantFiled: March 13, 2014Date of Patent: March 21, 2017Assignee: Bristol-Myers Squibb CompanyInventors: Yan Shi, Hao Zhang, Peter T. W. Cheng, Shiwei Tao
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Patent number: 9598391Abstract: The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.Type: GrantFiled: September 1, 2015Date of Patent: March 21, 2017Assignee: Lupin Atlantis Holdings SAInventors: Manojkumar Ramprasad Shukla, Ankush Gangaram Sarde, Rajeshkumar Maganlal Loriya, Vipul Dilip Pachpute, Navnath Bajirao Walke, Talha Hussain Khan, Sanjeev Anant Kulkarni, Venkata P. Palle, Rajender Kumar Kamboj
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Patent number: 9598392Abstract: A resist composition containing a compound represented by the general formula (1) or (2), a method for forming a resist pattern using the composition, a polyphenolic compound for use in the composition, and an alcoholic compound that can be derived therefrom are described.Type: GrantFiled: August 9, 2012Date of Patent: March 21, 2017Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.Inventors: Masatoshi Echigo, Masako Yamakawa
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Patent number: 9598393Abstract: The present invention is related to variants of mycolactones of formula (I), processes for the preparation thereof, pharmaceutical compositions thereof and their use in modulating inflammation, immunity and pain. Y—O—W (I), wherein Y and W are as defined in claim 1.Type: GrantFiled: November 16, 2012Date of Patent: March 21, 2017Assignee: Institut PasteurInventors: Caroline Demangel, Nicolas Blanchard, Georges Bismuth, Jacques Eustache, Virginie Casarotto, Anne-Caroline Chany, Laure Guenin-Mace
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Patent number: 9598394Abstract: Disclosed is a method of producing trioxane, including: (A) preparing trioxane from a high-concentration formaldehyde aqueous solution in the presence of an acid catalyst; (B) distilling a mixture including trioxane; (C) liquefying the distilled gas mixture; (D) mixing the liquefied liquid mixture with an extraction solvent and separating the mixture into an aqueous phase and a solvent phase; (E) distilling the solvent phase to give trioxane, and mixing the aqueous phase with the extraction solvent to give a mixture, which is then separated into an aqueous phase and a solvent phase; and (F) discharging the aqueous phase separated in (E) out of the system, and recirculating the solvent phase so as to be reused in (D) and (E).Type: GrantFiled: August 4, 2015Date of Patent: March 21, 2017Inventor: Sung Yong Baek
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Patent number: 9598395Abstract: Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.Type: GrantFiled: March 15, 2013Date of Patent: March 21, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Richard A. Gatti, Liutao Du, Hailiang Hu, Robert Damoiseaux, Michael E. Jung, Jin-Mo Ku, Gladys Completo
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Patent number: 9598396Abstract: The present invention provides compounds of formula (I), their use as inhibitors of tubulin polymerization and their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and Y have defined meanings.Type: GrantFiled: August 18, 2015Date of Patent: March 21, 2017Assignee: Janssen Pharmaceutica NVInventors: Patrick Rene Angibaud, Laurence Anne Mevellec, Bruno Roux, Pierre-Henri Storck, Christophe Meyer, Jorge Eduardo Vialard
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Patent number: 9598397Abstract: The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase and HIV replication, and the treatment of human immunodeficiency virus infection in humans.Type: GrantFiled: December 2, 2014Date of Patent: March 21, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Yang Cao, Donald R. Gauthier, Jr., Guy R. Humphrey, Tetsuji Itoh, Michel Journet, Gang Qian, Benjamin D. Sherry, David M. Tschaen
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Patent number: 9598398Abstract: The present invention relates to a compound represented by the formula (I), which is useful as an agent for the prophylaxis or treatment of epilepsy, neurodegenerative disease and the like. In the formula (I), each symbol is as defined in the specification.Type: GrantFiled: April 3, 2014Date of Patent: March 21, 2017Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Tatsuki Koike, Masato Yoshikawa, Haruhi Ando, William John Farnaby, Shuhei Ikeda, Yuichi Kajita, Toshiya Nishi