Abstract: A system and method for identifying changes in a state or activity is described. A real-time event monitoring application, implemented in a hardware processor, computes features over varying sampling periods, which are stored in cascading buffers. The various sampling periods enable determination of trends of a computed feature, comparison of the trends of the computed feature with trends of other features, normalization of the computed feature based on the same or different features at the same or different time scales, scaling of the normalized computed feature relative to other features at the same or different time scale, and identification of a change in state or activity based on a scaled normalized computed feature.

Abstract: Heart condition and function can be quantified using repolarization measures and/or repolarization indices derived from a time-frequency transform of an electrocardiogram, e.g., based on points in time associated with the T wave. The electrocardiograms, time-frequency maps derived therefrom, and/or indices obtained by analysis of the time-frequency maps and electrocardiograms may be assembled into a user interface. Further embodiments are described.

Abstract: ECG data is analyzed by detecting points in the ECG data which represent ventricular activity; measuring time intervals between each two consecutive points in the ECG data which represent ventricular activity; and then within a set of such time intervals, evaluating the time intervals by computing at least one comparative dimension for at least one time interval subset. The time interval subset includes at least two time intervals, and the comparative dimension represents variations between the interval lengths between the time intervals of the time interval subset.

Abstract: A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming s

Abstract: A biological signal acquisition device includes an electrode made up of a plurality of cell electrodes, and a controller that acquires an electrical signal from a biological body through a pair of cell electrode groups made up of a part or all of the plurality of cell electrodes. The controller determines a contact condition between the part or all of the plurality of cell electrodes and the biological body, based on a detection signal acquired by scanning the part or all of the plurality of cell electrodes. Further, the controller selects the cell electrodes making up the pair of cell electrode groups, based on the determined contact condition so that contact resistances between the cell electrode groups and the biological body are equal between the pair of cell electrode groups.

Abstract: A system for providing information about a patient's heart includes one or more electrodes that receive signals from electrical activity of the heart over one or more heart beat cycles. The system is characterized by an electronic processor coupled to the one or more electrodes to: receive the signals from the one or more electrodes; execute an automated set-up routine that processes the signals to automatically provide at least some set-up results for new mapping configurations; and/or process the signals with beat detection and beat acceptance criteria for new or existing mapping configurations to provide information about how well the signals match one or more of the new or existing mapping configurations.

Abstract: A system for providing information about a patient's heart, the system including one or more catheters that receive intracardiac signals from electrical activity of the heart over one or more heart beat cycles and an electronic processor coupled to the one or more catheters. The electronic processor to: receive the intracardiac signals from the one or more catheters; preprocess the intracardiac signals to provide preprocessed signals, wherein each of the intracardiac signals is preprocessed to provide a corresponding preprocessed signal; and compare the preprocessed signals to a set of signals to determine a degree of similarity between each of the preprocessed signals and the set of signals.

Abstract: An impedance measuring circuit has an amplification circuit connected to a target and to amplify a predetermined input signal with a gain corresponding to an impedance in the target and to output an output signal, a peak hold circuit to hold a peak value of the output signal and to output a hold value, and an impedance calculation circuit to calculate the impedance in the target based on the hold value.

Abstract: The present invention provides a rheology system (202) comprising a rheology transducer device (204) for introducing mechanical waves into a subject of interest (120), whereby the rheology transducer device (204) comprises multiple transducers (212), a driving device (206) for driving the rheology transducer device (204), a sensor device (208) for sensing mechanical waves at the subject of interest (120), and a control device (210) for receiving input from the sensor device (208) and for controlling the driving device (206) based on the received input from the sensor device (208). The present invention further provides a MR rheology system (200) comprising a MR imaging system (110), and the above rheology system (202), whereby the MR imaging system (110) is adapted to control the rheology system (200).

Abstract: An electronic skin is described herein. The electronic skin comprises a flexible capacitive sensor to capture a change in capacitance, wherein the change in capacitance is to translate to sheer, tensile, and torsion values. The electronic skin also comprises at least one section, wherein the one section is dielectrically separated from another section and the sheer, tensile, compression and torsion values are continuous across the at least one section and the another section.

Abstract: Methods and systems for the determination and representation of anatomy anatomical information are disclosed herein.

Abstract: An animal handling system (AMS), for positioning an immobilized animal in a predefined configuration therein, comprising an automated tuning unit, including: a proximal portion, held outside a medical device including: at least one inner shaft and at least one outer shaft, the at least one inner is telescopically maneuverable within the at least one outer shaft providing a variable telescopic mechanism; and a distal portion including: a configurable encapsuable life support system (ELSS), the ELSS is rotatable about a longitudinal axis of the at least outer shaft and the at least inner shaft and translationally moveable parallel to the longitudinal axis by means of the maneuverable telescopic mechanism.

Abstract: Systems and methods for epicardial electrophysiology and other procedures are provided in which the location of an access needle may be inferred according to the detection of different pressure frequencies in separate organs, or different locations, in the body of a subject. Methods may include inserting a needle including a first sensor into a body of a subject, and receiving pressure frequency information from the first sensor. A second sensor may be used to provide cardiac waveform information of the subject. A current location of the needle may be distinguished from another location based on an algorithm including the pressure frequency information and the cardiac waveform information.

Abstract: An airway adaptor includes a tubular member to which a measuring section configured to measure a flow rate of a respiratory gas of a subject is to be attached. The tubular member includes: a gas passage through which the respiratory gas to pass; and a resistance portion which is configured to generate a differential pressure in the respiratory gas passing through the gas passage, the resistance portion includes at least two partition members which are disposed in the gas passage along an axial direction of the tubular member and which are separated from one another, and side surfaces of the partition members are separated from an inner wall surface of the gas passage.

Abstract: A wearable sensor apparatus is disclosed that includes a flexible substrate adapted to be coupled with a skin surface of an expectant mother. A conductor is disposed on the flexible substrate. The conductor can include micron-scale invaginations. The conductor can be capable of repeatable variation in resistance when subject to a strain. Also disclosed is a system for monitoring the health of a fetus in utero that includes a wearable sensor apparatus. The wearable sensor apparatus is configured to output a signal responsive to an electrical input. The system includes a computing system with one or more hardware processors. The computing system is programmed to implement a signal processing module configured to access the output signal from the wearable strain gauge and generate an output indicative of health of the baby in utero.

Abstract: An apparatus is attached to one portion of a user's body for use, and has a detection unit that detects information corresponding to motion of the user. The apparatus measures an activity amount of the user based on information detected by the detection unit and, if multiple apparatuses are attached to the user's body, transmits information to an activity identification unit that identifies an activity being performed by the user based on information detected by the detection units of the attached activity amount measuring apparatuses and information indicating the attachment portions of the attached activity amount measuring apparatuses. The transmitted information is information that is detected by the detection unit and associated with the information indicating the identified attachment portion. The activity amount is corrected based on the activity that is identified.

Abstract: A motion recognition device includes a sensing unit and a processing unit. The sensing unit generates a sense signal in response to a body motion occurring at a specific position on a user's body, wherein the sense signal includes a first sense signal portion and a second sense signal portion different from the first sense signal portion, and the body motion belongs to a motion segment of a motion type. The processing unit processes the sense signal to generate a motion parameter signal structure including a fusion signal of the first and the second sense signal portions, and recognizes the specific position to determine an effective reference signal for recognition of the motion type based on the motion parameter signal structure.

Abstract: A motion capture system includes a wearable device (e.g. a glove) suitable for being worn by a user and including one or more markers having respective colors. A video camera acquires a sequence of color frames of the user moving while wearing the glove, while a range camera acquires corresponding depth frames of the same scene. A processing unit processes both color frames and depth frames for reconstructing the 3D positions of the markers. In particular, the depth information provided by the depth frames are used for isolating a validity area within the color frames, and the markers are searched based on their colors, exclusively within the validity area of the color frames. The movements of the user are then captured as a sequence of positions of the markers. Combined use of color information and depth information provide a very reliable and accurate motion capture.

Abstract: A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.

Abstract: A system for transdermal alcohol sensing to be worn near a skin surface of a user, including: an alcohol sensor; a microporous membrane; a housing coupled to the alcohol sensor and the membrane, defining a volume between the alcohol sensor and a first membrane side, and fluidly isolating the volume from a second membrane side opposing the first membrane side; an electronics subsystem electrically coupled to the alcohol sensor, operable to power and receive signals from the alcohol sensor; and a fastener operable to position the second membrane side proximal the skin surface.

Abstract: A biosensor is for sensing analytes in a fluid. The biosensor may include a first structural layer having a first hydrogel, a second structural layer having a second hydrogel, and a bioactive region extending between the first structural layer and the second structural layer and having a third hydrogel. The biosensor may include a first electrode coupled to the bioactive region, and a second electrode coupled to the first structural layer and being spaced apart from the bioactive region. The second structural layer may have a through opening adjacent the bioactive region, and the bioactive region may be configured to be in fluid communication with an environment external to the biosensor for receiving the fluid comprising the analytes.

Abstract: A method for determining the glucose value in blood or in interstitial liquids and to a glucose sensor including a catheter which has one or more openings in the region of the distal end of the catheter; a first optical waveguide which is arranged in the catheter and which includes a coupling surface at the distal end of the optical waveguide; a measuring probe which is arranged in the region of the distal end of the catheter, is coupled to the coupling surface of the first optical waveguide, and has a mirror arranged opposite the coupling surface of the first optical waveguide and a detection chamber between the coupling surface of the first optical waveguide and the mirror; a detection liquid for glucose in the detection chamber; and a membrane which encloses at least the detection chamber filled with the detection liquid and which has a separation capacity of maximally 20 kDA.

Abstract: Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

Abstract: Methods, devices, systems, and kits are provided that buffer the time spaced glucose signals in a memory, and when a request for real time glucose level information is detected, transmit the buffered glucose signals and real time monitored glucose level information to a remotely located device, process a subset of the received glucose signals to identify a predetermined number of consecutive glucose data points indicating an adverse condition such as an impending hypoglycemic condition, confirm the adverse condition based on comparison of the predetermined number of consecutive glucose data points to a stored glucose data profile associated with the adverse condition, where confirming the adverse condition includes generating a notification signal when the impending hypoglycemic condition is confirmed, and activate a radio frequency (RF) communication module to wirelessly transmit the generated notification signal to the remotely located device only when the notification signal is generated.

Abstract: Near-infrared spectroscopy (NIRS) is used to measure parameters such as pH of muscle tissue of a patient that is affected by a cardiac arrest. Analysis of the pH and other parameters such as SmO2 facilitates distinguishing between an arrhythmia arrest and an asphyxia arrest.

Abstract: A method for imaging and quantifying placental blood perfusion using magnetic resonance imaging is disclosed. The method provides a noninvasive means of assessing placental function and oxygenation from T2* images without the administration of an exogenous contrast agent. The method provides quantitative information regarding the number and spatial distribution of perfusion domains which subdivide the placenta into functional units where oxygen transport occurs, along with estimates of fetal oxyhemoglobin concentration, descriptors of placental oxygen reserve, and parameters representing the facility with which oxygen transport from the maternal to fetal vasculature occurs.

Abstract: According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; c) calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and d) using the calibrated sensor to determine the blood oxygen parameter value within the subject's tissue.

Abstract: A biological information measurement device may include a body; a probe unit; and a connection portion which electrically connects the body and the probe unit. The body may include a casing in which a battery and an electrical circuit are incorporated; and a first fitting portion which is attached to the casing and worn on a first fitted portion including a portion of at least one of a proximal phalanx and a middle phalanx of one or more fingers of the subject body. The probe unit may include a light source unit and a light receiving unit; and a second fitting portion which is worn on a second fitted portion including a distal phalanx of one or more fingers of the subject body.

Abstract: An embodiment of the present disclosure provides a noninvasive optical sensor or probe including disposable and reusable components. The assembly of the disposable and reusable components is straightforward, along with the disassembly thereof. During application to a measurement site, the assembled sensor is advantageously secured together while the componentry is advantageously properly positioned.

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

Abstract: A needle including a cannula having a multi-beveled point is disclosed. The multi-beveled point includes a primary bevel, two middle bevels, and two tip bevels. Each of the middle bevels extends between the primary bevel and one of the tip bevels. The primary bevel is provided on the cannula at a first angle of inclination and a first angle of rotation, the two middle bevels are provided on the cannula at a second angle of inclination and a second angle of rotation, and the two tip bevels are provided on the cannula at a third angle of inclination and a third angle of rotation. The third angle of inclination is greater than the second angle of inclination, the second angle of inclination is greater than the first angle of inclination, and the second angle of rotation is equal to the third angle of rotation.

Abstract: A method is disclosed for the mask-etching of a piercing element having an elongate shaft, a distally protruding tip, a proximal holding part, and a laterally open collecting channel that collects bodily fluid and extends along the shaft as far as the area of the tip, wherein a side of a double-sided etching mask is applied respectively to the two sides of a substrate and, under the action of an etching agent, the piercing element is formed as a part made by chemical blanking, wherein a channel side of the etching mask is provided with a channel etching slit for unilateral etching of the collecting channel.

Abstract: A system and method that enables a person to unobtrusively quantify the effect of mobility, physical activity, learning, social interaction and diet on cognitive function.

Abstract: An apparatus for measuring at least one measure related to urination of an individual such as urine flow rate and/or urine quantity. The apparatus is configured to produce acoustic and/or electromagnetic signals indicative of the at least one urination measure upon having urine applied thereover. The invention also provides systems and methods that detect the acoustic and/or electromagnetic signals originating from the apparatus being used by the individual and analyze the detected signals to calculate the at least one measure therefrom by using a designated application module operable via an end device using acoustic sensing means or data receiving means of the end device for detecting the acoustic and/or electromagnetic signals.

Abstract: A system and method of determining human performance capacity, and of determining the utility of a given biomedical intervention and/or neurotechnology device to characterize, to predict, and to influence human performance capacity, via analysis and interpretation of psychophysiological biomarkers of cognitive workload and functioning, assistive-technology/external support dependence, and compensatory behavior during performance of ecologically-valid standardized work samples.

Abstract: A method is described to facilitate breathing management.

Abstract: In some implementations, a computing device can remind a user to perform sleep ritual activities. The computing device can automatically determine the user's sleep ritual. The users sleep ritual can include various activities performed before going to sleep. The computing device can detect when the user performs the various sleep ritual activities. The computing device can remind the user about specific sleep ritual activities when the user forgets to perform the sleep ritual activities before going to sleep. In some implementation, the computing device can perform sleep ritual activities (e.g., turning off devices, locking doors, setting the air conditioning, etc.) on behalf of the user in response to user input. In some implementation, the computing device can perform sleep ritual activities on behalf of the user automatically and without user input.

Abstract: In some implementations, a computing device can confirm a sleep determination for a user based on secondary indicia of user activity. For example, the computing device can be a user's primary computing device. The primary device can predict and/or determine when the user is sleeping based on the user's use (e.g., primary indicia), or lack of use, of the primary device. After the primary device determines that the user is sleeping, the primary device can confirm that the user is asleep based on secondary indicia of user activity. In some implementations, the secondary indicia can include user activity reported to the primary computing device by other secondary computing devices (e.g., a second user device, a household appliance, etc.). In some implementations, the secondary indicia can include user activity detected by sensors of the primary computing device (e.g., sound, light, movement, etc.).

Abstract: Monitoring system configured to provide a health chart on an operator display. The health chart includes a plurality of indicators that identify patient parameters. The plurality of indicators form a column that extends parallel to a first axis. The health chart also includes linear projections that are aligned with respective indicators and extend parallel to a second axis that is perpendicular to the first axis. The linear projections represent values of the patient parameters that correspond to the respective indicators. The values are determined by the physiological data obtained from corresponding sensors. The patient monitoring system is configured to determine lengths of the linear projections based on the physiological data. The lengths extend from proximal ends of the linear projections to distal ends of the linear projections. The distal ends move parallel to the second axis toward or away from the respective indicators to change the length.

Abstract: Embodiments disclosed herein are directed to systems and methods for treating hypothermia in a subject is disclosed. In an embodiment, a method includes determining or measuring a temperature of a target region of the subject. The method also includes responsive to determining or measuring the temperature, directing electromagnetic energy at an external surface of the target region of the subject effective to heat the target region to a temperature of less than an ablation temperature of the target region.

Abstract: A patient treatment unit for analyzing and treating abnormality of human or animal tissues, includes a display; a pulse generator circuit that outputs a sequence of electrical pulses at a pulse frequency, the electrical pulses having a pulse width, the pulse generator controlling the pulse frequency and the pulse width of the electrical pulses; a pair of probes for contacting a body of a patient and electrically coupled to the pulse generator; and a voltage and current sensing circuit that senses a voltage or a current via the probes when contacting the body of the patient.

Abstract: A method, computer-readable medium and system of planning, guiding and/or monitoring a therapeutic procedure, can include: receiving a non-labeled therapeutic agent by a subject, said non-labeled therapeutic agent comprises at least one type of water-exchangeable proton that is exchangeable with protons in surrounding water molecules so as to enhance detection by a chemical exchange saturation transfer (CEST) process; acquiring a plurality of CEST magnetic resonance images of said non-labeled therapeutic agent within a region of interest of said subject for a corresponding plurality of times; and assessing at least one of a therapeutic plan or therapeutic effect of said non-labeled therapeutic agent in tissue of said subject based on said plurality of magnetic resonance images

Abstract: An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.

Abstract: There are provided a biological sensor control device, an operation method and operation program thereof, and a biological sensor system capable of effectively using the power of a battery of a wearable biological sensor device within a measurement period. In a case where the measurement period of a wearable biological sensor device is shortened, a determination unit changes the driving conditions so as to increase the driving power of the wearable biological sensor device by increasing the number of measurement items and/or by shortening the measurement interval. The determination unit determines the driving conditions in which the remaining capacity becomes a preset value or less at the end of the measurement period.

Abstract: A measuring apparatus includes a wearing portion to be worn by a subject, a sensor unit for acquiring the biological information of the subject while being supported by the wearing portion and in contact with a test site of the subject, and a protrusion disposed around the sensor unit. The protrusion protrudes further than the sensor unit toward the subject when the sensor unit is not in contact with the test site. When the wearing portion is worn by the subject, the protrusion contacts with a periphery of the test site and deforms before the sensor unit contacts with the test site, thereby stretching the skin of the test site to be contacted by the sensor unit.

Abstract: The present disclosure provides methods and techniques associated with a planar transformer for an apparatus. The planar transformers include a substrate carrying electronic components and a continuous core that is formed by distributing the encapsulant material uniformly around the substrate unit to define a consistent cross-sectional area for the magnetic path. The electronic components include primary windings and secondary windings associated with the transformer. In some embodiments, the encapsulant material is molded to seals air gaps to the substrate unit.

Abstract: The disclosure includes a system for sensing physiologic data. The system can include a flexible configured to wrap around a finger of a user, a first electrode coupled to the flexible strap, and a second electrode coupled to the flexible strap. The system can also include a sensor housing comprising at least one sensor configured to detect physiologic data from the finger and a data receiving module communicatively coupled to the first electrode, the second electrode, and the at least one sensor. The data receiving module can be configured to receive physiologic data from the at least one sensor.

Abstract: A wearable electronic device has a processing unit and a health sensor included in a housing, a band operable to couple the housing to a body part of a user, and a tightness sensor coupled to the band. The tightness sensor is operable to produce a signal indicative of a tightness of the band on the user's body part. The processing unit determines a tightness of the band based on the signal and perform one or more actions based thereon. Such actions may include evaluating the signal for changes in the tightness of the band according to operational tolerances of the health sensor, providing output directing the user to adjust the band to improve operation of the health sensor, monitoring changes in the tightness of the band and adjusting a measurement obtained by the health sensor, and so on.

Abstract: A wearable electronic device includes a body, a housing component, a band operable to attach the body to a body part of a user, and a force sensor coupled to the housing component. The force sensor is operable to produce a force signal based on a force exerted between the body part of the user and the housing component. A processing unit of the wearable electronic device receives the force signal from the force sensor and determines the force exerted on the housing component based thereon. The processing unit may use that force to determine a tightness of the band, determine health information for the user, adjust determined force exerted on a cover glass, and/or to perform various other actions.

Abstract: An instrument that utilizes body contact electrodes evaluates the quality of the connections made between the electrodes and the body. An electrode contact quality evaluation circuit performs the quality evaluation, such as by determining contact impedances for the electrodes. The corresponding contact quality of each electrode is conveyed to the user.