Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

Abstract: The present disclosure is directed, in part, to a curable composition, a method for augmenting a structure in a patient with a resorbable biocompatible polymer, and a biodegradable, resorbable implant comprising a biocompatible copolymer. An exemplary embodiment of the curable composition comprises (a) 60 wt. % to 95 wt. % of one or more vinyl ester monomers and/or vinylcarbonate monomers, wherein said one or more vinyl ester monomers and/or vinylcarbonate monomers are respectively selected from compounds of the general formulas (I) and (II) below: wherein n, m R1 and R2 have the meaning defined herein; (b) 0.1 to 40 wt. % of one or more multifunctional thiols; and (c) 0 to 10 wt. % of a biocompatible polymerization initiator.

Abstract: The present invention is directed to a stabilized cross-linked hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component that are covalently linked, and at least one stabilizing or enhancing agent, wherein the first high molecular weight component and the second high molecular weight component are each selected from the group consisting of polyglycans and polypeptides. This stabilized hydrogel matrix may be prepared as bioactive gels, pastes, slurries, cell attachment scaffolds for implantable medical devices, and casting or binding materials suitable for the construction of medical devices. The intrinsic bioactivity of the hydrogel matrix makes it useful as a gel or paste in multiple applications, including as a cell attachment scaffold that promotes wound healing around an implanted device, as gels and pastes for induction of localized vasculogenesis, wound healing, tissue repair, and regeneration, as a wound adhesive, and for tissue bulking.

Abstract: The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.

Abstract: The present invention relates to a method for producing an acellular dermal matrix, and to an acellular dermal matrix produced by same, and more particularly, to a method for producing an acellular dermal matrix, in which sucrose is added to base ingredients consisting of glycerol, propylene glycol, and a base solvent or solution so as to produce a cryoprotectant, the solution is injected into the skin below the epidermis and dermis from which cells have been removed, and freeze-drying is then performed.

Abstract: An injectable hydrogel, includes, in weight, in a physiologically acceptable carrier fluid: 0.01 to 5% of glycerol and 0.1 to 5% of cross-linked hyaluronic acid, or one of the salts thereof; characterized in that the hyaluronic acid or one of the salts thereof is cross-linked by the formation of covalent bonds using bifunctional or polyfunctional molecules, the injectable hydrogel being sterilized in moist heat and having viscoelastic properties such that Tan ? at a frequency of 1 Hz is less than or equal to 1.10. A method for producing the hydrogel, to a kit containing the hydrogel, as well as to the use thereof in dermatology are also described.

Abstract: The invention provides products of manufacture, e.g., biomaterials and implants, for cartilage maintenance and/or formation in-vivo, in-vitro, and ex-vivo, using nanotechnology, e.g., using nanotube, nanowire, nanopillar and/or nanodepots configured on surface structures of the products of manufacture.

Abstract: The present invention is a bone growth stimulating and promoting cytokine type biological implant preferably comprising PTH coated with a controlled release biodegradable coating that is implanted preferably in the concave side of a scoliotically curved spine in combination with a bone growth inhibiting type biological implant preferably comprising methotrexate or like anti-metabolite coated with a controlled release biodegradable coating that is implanted preferably in the convex side of a scoliotically curved spine. The insertion of the biological implant is highly non-invasion, especially as compared to more conventional spine surgical methods, and the biological implant does not decrease spinal mobility or spinal range of motion.

Abstract: Osteoinductive and osteoconductive compositions for bone graft which utilize less allograft tissue, and methods for their production, are provided. The compositions and methods contain a combination of fibers of demineralized bone matrix from allograft bone and fibers of non-allograft bone material. The fibers of non-allograft bone material comprise non-fibrous demineralized bone matrix particles embedded within or disposed on the fibers of non-allograft bone material. The non-allograft fibers of the composition contain a bone void filler of collagen and one or more ceramics embedded with demineralized bone matrix particles. In some embodiments, the composition also contains a bioactive agent.

Abstract: An object of the present invention is to provide a tube which can be easily torn and has a large heat-shrinkability at a low temperature. The tube of the present invention is a heat-shrinkable tube having tearability, including a mixture of a fluorine resin and a different kind of resin from the fluorine resin, in which an amount of change in loss energy, ?E loss, with change in temperature from 175° C. to 185° C. is a positive value.

Abstract: A method of coating surfaces of various body-implantable materials with control-releasable nitrogen monoxide using a catecholamine, more particularly, technology of preparing a coating film containing a diazeniumdiolate functional group on a surface of a material to be coated using a catecholamine, is provided. The coating film prepared by the method has advantages in that nitrogen monoxide can be stably supplied under an in vivo environment, and can be suitably used in a living body without causing cytotoxicity. Therefore, among the materials having a coating film formed on a surface thereof, the body-implantable material is especially expected to be widely used for medical and health applications including treatment of ischemic disorders such as arteriosclerosis through controlled release of nitrogen monoxide, regulation of penile erections, antibacterial and antiviral effects, and wound healing.

Abstract: This invention relates to hydrophilic polymer compositions and a preferred application therefore, viz., hydrophilic medical device coatings. The hyaluronic acid hyaluronon by itself or modified as described herein advantageously reacts with compositions disclosed in U.S. Pat. No. 7,776,956 to produce hydrophilic compositions and coatings particularly useable with medical devices.

Abstract: A fluid collection device for withdrawing a fluid from an object includes a chamber having a plurality of apertures and an opening for flow of the fluid. A tube is positioned in fluid communication with the opening of the chamber for withdrawing fluid out of the chamber. At least one of the apertures is positioned within a recess for substantially preventing clogging of the apertures during collection and removal of the fluid. The plurality of apertures may be interconnected by grooves for directing the flow and preventing clogging, of the apertures. The tube has a plurality of holes that are positioned within the chamber and held in place with a retaining ring. The apertures may be positioned so that spaces are provided between the apertures for placement of the tube or other devices. Exposed edges of the chamber and recesses are radiused for reducing irritation to a person.

Abstract: Systems and devices for treating a tissue site may include an interface adapted to provide a reduced pressure to a dressing. The interface may include a positive-pressure channel for delivering a positive pressure from a positive-pressure port to a positive pressure outlet. The positive-pressure channel may include a constricted portion configured to provide a pressure drop. The interface may additionally include a reduced-pressure channel adapted to deliver reduced pressure to the dressing that substantially corresponds to the pressure drop. The reduced-pressure channel may be fluidly coupled between the positive pressure channel and a side of the interface body adapted to face the dressing. Other systems and devices are disclosed.

Abstract: Systems, methods, and devices for milk expression are provided. In one aspect, a system includes an expression apparatus having an interface configured to engage a breast and an actuation assembly operably coupled to the interface. Actuation of the actuation assembly causes the interface to apply vacuum pressure against the breast to express milk from the breast. The system also includes various sensors for quantifying characteristics of the expressed milk, and a unique identifier allows inventory management of the expressed milk.

Abstract: A system and method for detecting and mitigating a suction condition are disclosed. The method may include estimating a flow waveform of the pump, identifying pulses in the flow waveform, determining a negative flow based on a valid identification of a pulse, and evaluating a characteristic of the pulse for an existence of a suction condition. In various embodiments, a suction marker is located based on a minimum in a diastolic phase, and the suction marker location is used to identify a probability of a suction condition. A speed of the pump may be adjusted to mitigate the suction condition. A system and method for estimating flow is further disclosed. The method may include interpolating data sets defining pump power to flow for various pump speed values.

Abstract: A blood pump having a rotor and a stator, in which the rotor has a filled core channel and a plurality of filled radial channels configured to maximize the communication of magnetic flux.

Abstract: A left-ventricular assist device (LVAD) has a generally ellipsoidal capsule fitted into a patient's ventricle, formed of a cage or frame of shape-memory wire which can be twisted open and shut to expand and collapse a thin membrane, to inflate with the incoming blood during diastole and to contract and squeeze out the blood during systole. A catheter extends from outside the patient's body through a major blood vessel and the patient's aortal valve into the left ventricle. The catheter has an external sheath, an outer tubular shaft onto which proximal ends of the shape-retaining wires are affixed, and a middle shaft extending through the hollow core of the outer shaft and which is affixed to a central shaft of the capsule. A control console has mechanical geared drives coupled to the outer and middle catheter shafts within the catheter. A sensor arrangement synchs action of the LVAD with systole and diastole of the patient's heart.

Abstract: Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end.

Abstract: A cassette is provided for installation in a dialysis monitor to pump a treatment solution through a dialyzer. The cassette is a unitary component with a hydraulic manifold (53) and a pneumatic manifold (54) integrated into a body (52). The body (52) has connectors for connecting the hydraulic manifold (53) to the dialyzer and the pneumatic manifold (54) to a pneumatic pressure source. A set of solution pumps is integrated in the cassette, and each solution pump includes a pump cavity inside the body. The solution pumps are operable to displace the treatment solution through the hydraulic manifold (53) to and/or from the dialyzer by action of a reciprocating gas-liquid interface in the pump cavity (30) of the respective solution pump. The gas-liquid interface is formed directly between a gaseous substance and the treatment solution.

Abstract: A mixing apparatus which can reliably prevent an auxiliary liquid from being unintentionally mixed into a main unit even when a failure occurs in a switching device, and which can prevent the switching device or an auxiliary flow route from being damaged even when a pressurizing device malfunctions due to the failure. The mixing apparatus includes a pipe circulating dilution water; a pipe circulating a disinfecting solution; a pressurizing pump circulating the disinfecting solution in the pipe toward the pipe; and a check valve capable of optionally turning on and off the pipe.

Abstract: A system and methods are described for improving the management of ischemic cardiac tissue during acute coronary syndromes or other ischemic conditions. A method and apparatus is described that allows mitigation of oxygen-related injury by precisely modulating the level of oxygen re-exposure during reoxygenation by a controlled feedback loop based on parameters of the tissue measured by a real-time tissue sensor or probe.

Abstract: A medical fluid pneumatic manifold system includes a plurality of pump and valve chambers for controlling a flow of medical fluid, a header including a plurality of pneumatic passageways, each passageway in pneumatic communication with one of the pump or valve chambers, a plurality of electrically actuated pneumatic valves, and a plate defining a plurality of pneumatic apertures, wherein the header and the plurality of electrically actuated pneumatic valves are separately attached to the plate, such that each pneumatic aperture in the plate is placed in pneumatic communication with one of the plurality of pneumatic passageways of the header and one of the electrically actuated pneumatic valves.

Abstract: A method for filling and venting a device for extracorporeal blood treatment is disclosed, such as a patient module in a heart-lung machine, without attached patient. A filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the system into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir, wherein a first controllable valve (HC1) for a venting line of a filter is opened and, after the response of an upper filling level sensor in the reservoir, is closed. An upper level of the filter is positioned higher than the upper filling level sensor, and a start-stop motion of the blood pump is performed, as a result of which a stepped flooding of the filter is made providing for an advantageous de-airing of the device.

Abstract: A device for holding fluid has a spout for pouring the fluid. The device includes a lid with an aperture. The aperture can be covered by a user's fingers or uncovered to control the flow of fluid out of the spout.

Abstract: A medical device package includes a medical device including a first end surface and a second end surface; and a medical device storage container configured to store the medical device, the medical device storage container including a container main body and a holding unit located in the storage space, and configured to hold the medical device such that the first end surface faces upward; and a sheet-like sealing member adapted to be glued to the container main body to seal an opening of the container main body. A surface of the sealing member that faces the container main body includes an adhesive applied area on which an adhesive is applied and an adhesive non-applied area on which the adhesive is not applied, the adhesive non-applied area being an area facing at least the first end surface of the medical device held by the holding unit.

Abstract: A pump is disclosed that comprises a primary control unit comprising a first processor and one or more modular pumping units removably docked to the primary control unit. Each modular pumping unit comprises a pumping mechanism and a second processor configured to control the pumping mechanism and communicate with the first processor. The modular pumping unit is configured to manipulate a portion of a fluid delivery set to pump a fluid. The first processor and the second processor are configured to exchange one or more operating parameters when the modular pumping unit is docked to the primary control unit. The modular pumping unit is configured to pump the fluid after being undocked.

Abstract: Apparatuses, systems and methods for the wireless communication of medical devices in a subcutaneous fluid delivery system are disclosed. A system for subcutaneous fluid delivery includes a primary patch pump adapted to attach a first infusion cannula to a user and to perform a plurality of primary patch pump functions, and a secondary patch pump adapted to attach a second infusion cannula to a user. The secondary patch pump is further adapted to perform a plurality of secondary patch pump functions substantially similar to the plurality of primary patch pump functions if an error condition associated with the primary patch pump is determined.

Abstract: In various embodiments, an implantable pump includes a cannula. The pump (e.g., the cannula thereof) may include, for example, flow sensors, pressure sensors, filters, and/or other components.

Abstract: A tubing set suitable for use in co-operation with a medical liquid delivery device includes a delivery tube configured to supply a medical liquid or blood to a patient, and a vial gate for the connection of vials containing drugs to be delivered into the medical liquid or blood. The vial gate includes a delivery lumen configured to deliver the drug from the vial to the delivery tube, and a vent lumen configured to deliver a replacement fluid from a location inside the tubing set to the inside of the vial in order to replace the delivered drug. The vial gate also includes at least one one-way valve placed along the vent lumen or the delivery lumen.

Abstract: A testing device (10), an infusion pump or another medical device function testing method, to an anesthesia apparatus or respirator (AB) and to a computer program product are provided for testing the function of an infusion pump (G). The testing device (10) is preferably implemented on the anesthesia apparatus or respirator (AB) and comprises a memory (MEM), a test module (T) and a controller (C). The test module (T) sends a test command (20) to the infusion pump (FG), which sends a response (30) back to the controller (C) after execution of the command. The control (C) can then compare the response (30) received with a reference response (30?) for agreement in order to send a successful function test result.

Abstract: A method of infusing and aspirating fluid from the body is provided. The method includes providing a catheter system which includes an inner lumen, the proximal end of which is connected to an infusion mechanism configured to control infusion of a fluid, and an outer lumen, the proximal end of which is connected to an aspiration mechanism configured to control aspiration of fluid from the body. The method also includes activating the infusion mechanism to infuse fluid into the body for a first infusion time period and at a first infusion pressure, disabling the infusion mechanism to stop infusion, and activating the aspiration mechanism to aspirate fluid for a first aspiration time period and at a first aspiration pressure.

Abstract: A deployable infection treatment system includes a cannula device comprising a cannula body having a proximal end, a flared distal end, and a lumen extending therebetween. The lumen has a longitudinal x-axis extending therethrough. A sponge or drain is provided, the sponge having a distal end and a proximal end, wherein in a non-deployed configuration, the sponge is compressed within the cannula body's lumen and in a deployed configuration the distal end of the sponge expands out of the cannula body's lumen. An integrated pump and vacuum device is provided, wherein when the sponge is in a deployed configuration, the device is in fluid communication with a therapeutic fluid source. The pump controls the delivery of the therapeutic fluid to the proximal end of the sponge. The vacuum controls the extraction of the therapeutic fluid and infectious material from the proximal end of the sponge.

Abstract: Processor-implemented methods of controlling an insulin infusion device for a user are provided here. A first method obtains and analyzes calibration factors (and corresponding timestamp data) for a continuous glucose sensor, and regulates entry into a closed-loop operating mode of the infusion device based on the calibration factors and timestamp data. A second method obtains a most recent sensor glucose value and a target glucose setpoint value for the user at the outset of the closed-loop mode. The second method adjusts the closed-loop insulin infusion rate over time, in response to the sensor glucose value and the setpoint value. A third method calculates an upper insulin limit that applies to the insulin infusion rate during the closed-loop mode. The insulin limit is calculated based on a fasting blood glucose value of the user, a total daily insulin value of the user, and fasting insulin delivery data for the user.

Abstract: This pharmaceutical injection system is provided with a pharmaceutical injection device, a charging device, a detector, and an alarm section. The pharmaceutical injection device has a main body case and a pharmaceutical syringe mounting portion provided within the main body case and to which a pharmaceutical syringe is removably mounted. The pharmaceutical injection device is placed in the charging device, and the charging device has a charger for charging the pharmaceutical injection device. The detector is provided to the pharmaceutical injection device and/or the charging device and detects whether or not the pharmaceutical syringe has been mounted to the pharmaceutical syringe mounting portion. The alarm section is connected to the detector and emits an alarm when it is detected that the pharmaceutical syringe has been mounted onto the pharmaceutical syringe mounting portion.

Abstract: The invention relates to an auto-injector for administering a dose of a liquid medicament, comprising: an elongate tubular case, a carrier subassembly comprising a tubular carrier slidably arranged inside the case, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier, wherein the drive spring acts between the carrier and the plunger, wherein the plunger in an initial state is locked to the carrier by a ramped engagement to the carrier and by being prevented from rotating out of this ramped engagement depending on a relative longitudinal position of the carrier in the case, wherein the plunger is arranged to be released for rotating out of the ramped engagement upon the needle reaching at least nearly a predefined injection depth on translation of the carrier in the proximal direction for advancing the needle beyon

Abstract: A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member an a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged within an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.

Abstract: An engine for an-auto injector for administering a dose of a liquid medicament includes a case arranged to be attached to a package syringe containing a syringe. The case contains a drive capable of, upon activation, pushing the needle from a covered position into an exposed position, and operating the syringe to supply the dose of medicament. The case contains a trigger arranged to lock the drive in a loaded state prior to manual operation and capable of, upon manual operation, releasing the drive for injections. The drive is arranged as a gas spring including a cylinder and a piston with a plunger for transmitting the spring force. A latch is arranged for preventing translating between the cylinder and the case. The latch is disengageable by the released gas spring being at least nearly fully extended thus allowing the extended gas spring to be translated in a distal direction.

Abstract: A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.

Abstract: An assembly for a drug delivery device is provided, comprising a housing, a rotation member adapted and arranged to be rotated in a first and in a second rotational direction with respect to the housing in an operational mode of the assembly, a drive member which is configured to mechanically cooperate with the rotation member such that the drive member follows rotation of the rotation member when the rotation member is rotated in the second rotational direction and such that the rotation member rotates with respect to the drive member when the rotation member is rotated in the first rotational direction, and a piston rod. The assembly further comprises at least one biasing member which is adapted and arranged to provide a force tending to bring the rotation member and the drive member out of mechanical cooperation in the operational mode. The assembly is switchable from the operational mode into a reset mode.

Abstract: A gasket having a novel structure ensuring both the gas tightness and the low-friction slidability is provided. A sliding portion of the gasket (13) includes at least a first annular projection (17A), an annular recess and a second annular projection (17B) arranged in this order in a direction rearward from a distal portion of the gasket serving as a liquid contact portion. The first projection (17A) is designed so that a first peak appears adjacent the distal portion of the gasket when the gasket is fitted in the syringe barrel (11) and a product ? of a contact pressure P1f and a width D1f of the first peak is 0.4???1.0 as determined by an FEM analysis.

Abstract: A resettable dosing mechanism comprises a dose button and a dial grip operatively coupled to the dose button. A spindle acts on a bung of a cartridge and a driver is operatively coupled between the dose button and the spindle. During an injection of the dose, the dose button moves in an axial direction to cause the spindle to administer the dose. During resetting of the dose setting mechanism, the spindle is retracted back into the dose setting mechanism.

Abstract: Drug injection device (400) comprising expelling means for expelling an amount of drug from a reservoir, the expelling means comprising setting means (411) allowing a user to set a dose to be expelled, and actuation means (413) for releasing the drug expelling means to expel the set dose. The actuation means comprises an actuation member adapted to be moved between an initial position, an intermediate position, and an actuated position in which the expelling means is actuated to expel the set dose. The device further comprises an electronically controlled capturing system (420) for capturing data representing the amount of drug expelled from the reservoir by the expelling means, and switch means for starting initialization of the capturing system when the actuation member is moved to its intermediate position.

Abstract: A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device.

Abstract: The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. The dose dial sleeve may have a helical thread of first lead and the drive sleeve may have a helical groove of second lead. The first lead of the helical thread and the second lead of the helical groove may be the same.

Abstract: Syringe systems and flow control systems configured to detect information associated with a liquid material are described. The syringe systems may include a syringe body for housing the liquid material and an injector piston for expelling the liquid material out of the syringe through a discharge outlet at a distal end of the syringe body. Components of the syringe, such as an injector piston, may include sensors configured to measure and/or detect a property of the liquid material, such as concentration, pH, or radioactivity. The flow control system may include a pinch valve and a platen arranged about a fluid delivery channel. Flow within the fluid delivery channel may be controlled by increasing (squeezing the fluid delivery channel) or decreasing the distance between the pinch valve and the platen. Components of the flow control system may include detectors configured to detect properties of fluid in the fluid control channel.

Abstract: A safety shield system (60) for a compression syringe (10) having a compressible reservoir (46), a needle cannula (12) for fluid communication with the reservoir (46) and having a forward tip (16), the safety shield system (60) having at least a holder shield portion (62) designed to be attached to the compression syringe (10), and a movable shield portion (64), designed to be movable relative to the compression syringe (10) from a first position wherein the tip (16) is exposed, to a second position wherein the movable shield portion (64) covers the tip (16). The holder shield portion (62) and movable shield portion (64) being provided with retainer (51, 52, 70) arranged to cooperate in the first position to prevent the movable shield portion (64) from moving toward its second position.

Abstract: A safety shield for use with a hypodermic syringe device is disclosed. The safety shield is moveable relative to the syringe barrel between retracted position and a needle containing position. In the retracted position, the syringe device may be used to inject the needle into the patient. After the medication has been injected or as the needle is withdrawn from the patient, in its operative mode the shield automatically extends from its retracted position to a needle containing position to shield the point of the needle to prevent accidental sticks and without further input from the operator to render the syringe unusable after a single injection.

Abstract: In a first aspect, a safety pen needle assembly is provided herein which includes a hub and a needle fixed to the hub which extends distally from the hub so as to define an injection length. A first shield is slidable relative to the hub from a first state, in which the shield covers at least a substantial portion of the injection length of the needle, to a second state, in which at least a substantial portion of the injection length of the needle is exposed; and, a second shield is slidable from a first position, in which the shield covers the proximal end of the needle, to a second position, in which the proximal end of the needle is exposed. A biasing element is disposed between the first and second shields configured to simultaneously urge the first shield distally and the second shield proximally.