Abstract: In one example a pulse measurement system, comprises at least one sensor positioned to collect pulse information at three separate locations along a body segment, a controller communicatively coupled to the at least one sensor to receive the pulse information from the at least one sensor, and a display coupled to the controller to present at least one characteristic of the pulse information detected at the three separate locations. Other examples may be described.

Abstract: A pulse wave analyzer includes: a pulse wave acquirer which is configured to acquire a pulse wave of a subject; a respiration information acquirer which is configured to acquire respiration information of the subject; and an analyzing section which includes: a detector which, based on the respiration information, configured to detect that spontaneous respiration is generated, and to detect an end-tidal phase of the spontaneous respiration; and an eliminator which is configured to eliminate a unit pulse wave that, in the pulse wave, is generated immediately after the end-tidal phase of the spontaneous respiration, from the pulse wave, wherein the analyzing section is configured to calculate a respiratory variation from the pulse wave from which the unit pulse wave has been eliminated.

Abstract: A pulse wave analyzer includes: a pulse wave acquirer which is configured to acquire a pulse wave of a subject; an electrocardiogram acquirer which is configured to acquire an electrocardiogram of the subject; a respiration information acquirer which is configured to acquire respiration information of the subject; and an analyzing section which includes: a setting section which is configured to set a selection criterion based on the pulse wave or the electrocardiogram, and the respiration information; and a selecting section which is configured to select a pulse wave based on the selection criterion, wherein the analyzing section is configured to calculate a respiratory variation from the pulse wave which is selected by the selection section.

Abstract: A method for monitoring autoregulation includes, using a processor, using a processor to execute one or more routines on a memory. The one or more routines include receiving one or more physiological signals from a patient, determining a correlation-based measure indicative of the patient's autoregulation based on the one or more physiological signals, and generating an autoregulation profile of the patient based on autoregulation index values of the correlation-based measure. The autoregulation profile includes the autoregulation index values sorted into bins corresponding to different blood pressure ranges. The one or more routines also include designating a blood pressure range encompassing one or more of the bins as a blood pressure safe zone indicative of intact regulation and providing a signal to a display to display the autoregulation profile and a first indicator of the blood pressure safe zone.

Abstract: A smart home-care health device includes a health device including a master control board for household application. The master control board is electrically connected with multiple modules arranged in the health device. The detection modules connected to the master control board include a blood glucose detection module, a sleep detection module, and a heart detection module, which allow for acquisition of detailed and correct data of a target body through non-contact detections and allows, through feed-back, transmission to the master control board for judgment in order to establish personal dedicated message corresponding to the status of the target body and allow for message transmission to a clinic or a hospital and electrical appliances to allow family members to receive perfect home care of smart home.

Abstract: Provided herein are methods, systems, and apparatuses for measuring a bio-signal of a user. In one embodiment, a bio-signal measuring apparatus is provided that can operate by being combined with a plurality of target devices. For example, the bio-signal measuring apparatus can include an electrocardiogram (ECG) sensor. One or more PPG sensors can be included with a light emitting portion for generating light and a light receiving portion for receiving the light which is irradiated. The bio-signal measuring apparatus can be configured to measure one or more bio-signals using one or more of an ECG sensor and a PPG sensor, and the biological signal measuring apparatus can be configured to recognize the type of target device with which it is combined, activate a bio-signal measuring function, and correct bio-signal values.

Abstract: In a pulse wave signal processor, a first filter attenuates a frequency component in an acquired pulse wave signal or in a differentiated pulse wave signal, and the attenuated frequency component is more than or equal to a first frequency. A second filter attenuates a frequency component in the acquired pulse wave signal, and the attenuated frequency component is less than the first frequency and more than or equal to a second frequency. A characteristic-point extractor extracts a characteristic point that exists in each single pulse of the pulse wave signal filtered by the second filter, and a signal separator partitioning the pulse wave signal or the differentiated signal filtered by the first filter into sections such that each section includes one of the extracted characteristic points. The partitioned sections are overlapped such that the characteristic points are coincident with each other, and arithmetically averaged.

Abstract: An implantable medical device includes a housing having a proximal end and a distal end, a control module enclosed by the housing, and a pressure sensor electrically coupled to the control module. A fixation member is coupled to the housing distal end for anchoring the housing distal end at a fixation site within a cardiovascular system of a patient, and the pressure sensor is spaced apart proximally from the fixation member.

Abstract: Methods for measuring blood flow speed within blood vessels using a PA imaging system are disclosed. The methods include position a field of view of a PA imaging system along a section of a blood vessel, introducing a PA discontinuity into the blood flow within the blood vessel upstream of the FOV of the PA system, monitoring the movement of the PA discontinuity during movement through the FOV of the PA imaging device, and calculate the blood flow speed using at least two measured positions and corresponding times of the PA discontinuity within the FOV of the PA imaging system. PA discontinuities may include blood surges formed by compressing and releasing the blood vessel and/or boluses of a fluid with high PA contrast relative to the blood, such as saline solution.

Abstract: A blood pressure monitoring system is provided comprising: an impedance monitoring circuit configured to detect an occurrence of a blood pulse wave ejection from the heart; a blood pulse detection circuit detect to an arrival of the blood pulse wave at a body site peripheral to the heart; and a processor configured to compute pulse transit time (PTT) based at least in part upon a difference in a time of occurrence of the blood pulse wave ejection from the heart first signal and a time of occurrence of the arrival of the blood pulse wave at a body site peripheral to the heart.

Abstract: Characterization of a fitness monitor based on its operation enables a processor to account for variations in device operating modes and biometric characteristics of the user. The fitness monitor includes an emitter (e.g., LED) for transmitting light toward skin of the user, a receiver (e.g., photodiode) for receiving a reflection of the transmitted light, a photometric front end for generating a photoplethysmogram (PPG) signal based on the received reflection, and a processor configured to select an intensity level for the emitter based on a comparison of a determined component of the PPG signal and a reference value. The reference value, which may characterize the fitness monitor based on a determined variability or range of the PPG signal, may be utilized by the processor to improve or maintain the signal quality of the PPG signal to enable determination of a cardiac component and/or reduction of power consumption by the fitness device.

Abstract: A noninvasive light sensor for detecting heart beat signals has a circular support member engageable circumferentially with a body part of a person. There are a plurality of light emitters and light detectors located around a circumference of the circular support member for respectively emitting light signals into different areas of tissue surrounding the body part, and receiving reflected light signals from the different areas of tissue surrounding the body part.

Abstract: An adaptive optical objective inspection instrument for optic nerve function comprises: a sub-system for measuring wave aberration of human's eyes, including a near infrared beacon light source, an intermediate optical system, a wavefront corrector and a wavefront sensor, configured to measure and obtain wave aberration of testee's eyes, the intermediate optical system arranged along an optical path between the near infrared beacon light source and the wavefront sensor, and the wavefront corrector arranged in the optical path of the intermediate optical system; a sub-system for correcting wave aberration of human's eyes, including the intermediate optical system, the wavefront corrector and a control unit, the control unit configured to drive and control the wavefront corrector to correct the wave aberration of testee's eyes according to the measured wave aberration; and a sub-system for inspecting optic nerve function, including a visual stimulus display and a system for collecting visual evoked potential si

Abstract: Described herein are microelectrode devices to provide localized neural recording or neural stimulation to a neurological target. The device includes a plurality of electrodes disposed along the shafts of deployable flexible pins. The deployable flexible pins are enclosed within an elongated probe shaft, and can be expanded from their enclosure. Additionally, a specifically manufactured outer housing can be coupled to at least a portion of the elongated probe shaft. During deployment of the flexible pins the outer housing of the microelectrode device reduces friction between the flexible pins and the probe shaft and reduces delamination of the flexible pins during deployment.

Abstract: Systems and methods are provided to detect a multi-domain ECG waveform and display one or more cardiac electrophysiological markers. Electrical impulses are detected between at least one pair of electrodes adapted to be located near a beating heart and are converted to an ECG waveform. The ECG waveform for at least one heartbeat is received from the detector, the ECG waveform is converted to a frequency domain waveform, the frequency domain waveform is separated into two or more different frequency domain waveforms using two or more different bandpass filters, and the two or more different frequency domain waveforms are converted into two or more different time domain waveforms. The two or more different time domain waveforms are displayed in the same time domain plot as the ECG waveform and one or more cardiac electrophysiological markers are displayed along the x-axis of the two or more different time domain waveforms.

Abstract: The present disclosure provides a GPU-based parallel electrocardiogram signal analysis method, comprising: performing a filtering process of electrocardiogram signals through a long interval artifact removal and a short interval artifact removal; performing a QRS detection of the filtering-processed electrocardiogram signals through an R-wave position extraction, a QRS complex start and end positions extraction and a QRS complex width extraction; performing an abnormal waveform classification of the QRS-detected electrocardiogram signals through template creation; wherein at least one of the long interval artifact removal, the short interval artifact removal, the R-wave position extraction, the QRS complex width extraction and the creation template is performed by a multiple threads at a GPU device side in parallel, any thread being read through its unique index number to process corresponding data.

Abstract: The system and method provide for electrocardiogram analysis and optimization of patient-customized cardiopulmonary resuscitation and therapy delivery. An external medical device includes a housing and a processor within the housing. The processor can be configured to receive an input signal for a patient receiving chest compressions and to select at least one filter mechanism and to apply the filter mechanism to the signal to at least substantially remove chest compression artifacts from the signal. A real time dynamic analysis of a cardiac rhythm is applied to adjust and integrate CPR prompting of a medical device. Real-time cardiac rhythm quality is facilitated using a rhythm assessment meter.

Abstract: A system includes an array of electroencephalography (EEG) electrodes for placement on the head of a subject and a transcranial magnetic stimulation (TMS) device. A controller is configured to operate the array of EEG electrodes to acquire a plurality of EEG signals concurrently with operation of the TMS device to apply a TMS pulse to the head of the subject. The controller is further configured to select an initial set of EEG signals from the EEG signals and to fit an initial decreasing rational function of time to a TMS artifact component of each EEG signal of the initial set. The TMS artifact component of each remaining EEG signal is fit to a linear combination of the initial decreasing rational functions. Each EEG signal is corrected by removing from the EEG signal the function that is fit to the TMS artifact component of the EEG signal.

Abstract: Systems, methods and devices relating to a physiological sensor system to be worn on a subject's skin to measure, process or store one or more physiological parameters, the system comprising: at least one pair of sensing electrodes that measure, when in contact with the subject's skin, physiological signals indicative of the one or more physiological parameters; first and second reference electrodes that concurrently provide a source signal and a reference signal for said sensing electrodes in their measurement of the one or more physiological parameters; and a subject-securing device for securing said sensing electrodes and said first and second reference electrodes against the subject's skin in operation.

Abstract: A computer implemented method, system and software for detection of a biological condition including instructions for measuring a frequency modulated auditory evoked response of a subject and analyzing the frequency modulated auditory evoked response to detect the presence or absence of the biological condition in the subject. The biological condition can be an autism spectram disorder.

Abstract: Implementations are disclosed for monitoring a state or change in state of a physiological parameter based on measured impedance data. In certain implementations, no images are reconstructed from the impedance data. In certain implementations, a metric (e.g., distinguishability, likelihood ratios, and so forth) may be computed and compared to reference metrics or thresholds, such as for changes over time or in comparison to a standard to determine the presence or absence of a physiological state of interest or of a change in such state.

Abstract: Systems and methods are provided for processing a set of multiple serially acquired magnetic resonance spectroscopy (MRS) free induction decay (FID) frames from a multi-frame MRS acquisition series from a region of interest (ROI) in a subject, and for providing a post-processed MRS spectrum. Processing parameters are dynamically varied while measuring results to determine the optimal post-processed results. Spectral regions opposite water from chemical regions of interest are evaluated and used in at least one processing operation. Frequency shift error is estimated via spectral correlation between free induction decay (FID) frames and a reference spectrum. Multiple groups of FID frames within the acquired set are identified to different phases corresponding with a phase step cycle of the acquisition. Baseline correction is also performed via rank order filter (ROF) estimate and a polynomial fit.

Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs.

Abstract: Electron paramagnetic resonance (EPR) systems and methods for transcutaneous oxygen monitoring (TCOM) and subcutaneous oxygen monitoring (SCOM) are provided herein. Optionally, the EPR systems provided herein can be portable and/or handheld to facilitate EPR oximetry in clinical environments.

Abstract: A fat thickness estimating device includes a storage unit that stores information indicating relationship between fat thickness and ratio of bioelectrical impedance in a first condition and bioelectrical impedance in a second condition, a measured impedance value acquiring unit configured to acquire a measured impedance value in the first condition of a target living body and a measured impedance value in the second condition of the target living body, and an estimation unit configured to calculate a fat thickness value in the target living body based on the information and a ratio of the measured impedance value in the first condition and the measured impedance value in the second condition.

Abstract: Method and apparatus for estimating bio-impedance at electrode-electrolyte interface by injecting a single low-intensity bi-phasic current stimulus having an selected inter-pulse delay first and second current pulse phases, which involves acquiring transient electrode voltage along the bi-phasic current stimulus waveform. Determining equivalent circuit parameters of an electrode, at the electrode-electrolyte/tissue interface, based on transient electrode voltage across said multiple temporal locations is also performed.

Abstract: The present invention provides a device and a method for monitoring the function of sphincters in the gastrointestinal (GI) tract. The device of the invention includes a signal-generating device that is placed at one side of a GI sphincter, and a signal-detecting device that is placed at the other side of the GI sphincter whose function is to be monitored. The device detects and analyzes the change in the characteristics of the signals that are generated by the signal-generating device and detected by the signal-detecting device. In this manner, the signal data detected during the opening and closing of the GI sphincter can be stored in a data logger and/or can be monitored in real time.

Abstract: A system for the control of an implant (32) in a body (11), comprising first (10, 20) and second parts (12) which communicate with each other. The first part (10, 20) is adapted for implantation and for control of and communication with the medical implant (32), and the second part (12) is adapted to be worn on the outside of the body (11) in contact with the body and to receive control commands from a user and to transmit them to the first part (10, 20). The body (11) is used as a conductor for communication between the first (10, 20) and the second (12) parts. The second part (12) is adapted to receive and recognize voice control commands from a user and to transform them into signals which are transmitted to the first part (10, 20) via the body (11).

Abstract: The present invention provides an improved breath analyzer and breath test method to determine the presence of H. pylori in a subject's digestive tract.

Abstract: A disposable measuring tool is disclosed for used during the implantation of a penile prosthesis cylinder. The measuring tool permits an accurate measurement of a dilated corpus cavernosum prepared to accept and penile prosthesis cylinder.

Abstract: A system for determining the alignment measurement of the foot and ankle is disclosed. The system uses data representative of a three dimensional scanned image of a patient's foot and ankle while the patient was applying weight on the foot. Next the system detects the three dimensional coordinates associated with at least three predetermined landmarks on the patent's foot in the scanned image. A ground plane is determined using the predetermined landmarks. A center of a talar dome is determined in the scanned data. An ankle offset lever arm id determined from the set of landmarks and center of the talar dome.

Abstract: A method for determining a rate of repetitive bodily motion of an individual with negligible contact with the individual begins by one or more computing devices transmitting a signal for reflection off of the individual, receiving a reflected signal, and down-converting the reflected signal to a baseband signal. The method continues with one or more computing device applying a frequency estimation algorithm to the baseband signal to produce an estimated spectral density, and applying a repetitive bodily motion pattern search function to the estimated spectral density to estimate the rate of the repetitive bodily motion of the individual.

Abstract: Systems and processes for measurement of the eyelid movements of a subject, which explores eyelids' electrical conductivity, namely the established fact that eyelids are acting as sliding electrodes moving over the cornea, is comprised of a system for generating a high frequency weak and harmless oscillating electromagnetic field in the proximity of the eyelid movement path without interference with the vision or activity of any such subject, therefore induces so-called Eddy Currents in the eyelid, which in its turn produce its own electromagnetic field with a value depended on the eyelid position; the interaction between the basic oscillating electromagnetic field and the field generated by the eyelid is changing electromagnetic field inductance, which will be measured with very high accuracy by means of resonance sensing electronics; such systems can transmit data from its detecting electronics to a remote monitor that compels no restrictions on operator activity.

Abstract: The present disclosure provides device and method for measuring cervical vertebra movement. The device comprises a sensor unit, a computation unit, a storage unit and a determination unit. The sensor unit comprises at least one transmission part and at least one reception part. Either of the transmission part and the reception part moves along with user's head, the other fixes relative to user's body. The transmission part transmits detection signals and the reception part receives them. The computation unit computes, based on detection signals, distance changes in a distance between the transmitting and reception part before and after user's head moves. The storage unit stores a mapping table indicating relations between distance changes and movement angles of user's head. The determination unit inquires the mapping table based on distance changes to determine movement angles of user's head. The device is simple, easily operated and practicable.

Abstract: An emotion estimating method includes: acquiring first data and second data from the subject, the first data corresponding to physiology data, and the second data corresponding to one of physiology data different from the first data and non-physiology data; calculating a first value and a second value based on the acquired first data and second data, the first value indicating a degree of arousal of the subject and the second value indicating a degree of valence of the subject; estimating the emotion of the subject, by using the calculated first value and second value and based on a predetermined association of people's emotions with a degree of arousal and a degree of valence of the people, the predetermined association being pre-stored in a memory; and outputting information indicating the estimated emotion.

Abstract: Current glucose meters provide instantaneous results however are invasive and painful thus causing reduced compliance. A non-invasive, portable, wearable device would be ideal for monitoring and recording and provide a distinct advantage to current glucose monitors.

Abstract: The current invention pertains to an apparatus and method for the determination of excess post-exercise oxygen consumption (EPOC) and the estimation of blood lactate levels. While these exercise parameters are traditionally determined using indirect calorimetry and blood sampling, this invention provides a method for the determination of these parameters using heart rate data. A wearable photoplethysmography device for measuring heart rate is included as an exemplary embodiment, however, the method of the current inventions can also be used with heart rate data from any heart rate monitor. In an embodiment of the present invention a supply demand differential equation is used to continuously monitor EPOC in real-time. Furthermore, blood lactate levels can also be estimated as a function of EPOC.

Abstract: A needle guide assembly for vein access including (a) a guide having a convex portion, a concave portion, an aperture and a stabilization means for stabilizing a vein against moving away and escape puncture, where the concave portion and the convex portion meet each other to define the aperture between the concave portion and the convex portion, each of the convex portion and the concave portion extending away from the aperture in opposite directions from each other in a tapering manner and terminating the tapering at respective locations away from the peripheral edge, the convex portion being made of a transparent or translucent material, the stabilization means being a pair of elongated indentations that extend substantially parallel to each other and between which are the convex portion, the concave portion and the aperture, and (b) a retaining means for retaining the guide to skin.

Abstract: Disclosed are cognitive function test device and method, the cognitive function test device including a content information generator configured to generate content information from a content of a user, a question and answer data generator configured to generate at least one question and answer data based on the content information, and a question and answer executor configured to provide a question related to the content and to evaluate an answer to the question based on the at least one question and answer data.

Abstract: A trip stress monitoring method and device comprise receiving a geo-location data point, receiving a physiological measurement of a user and associating the physiological measurement to the received geo-location data point, storing the received geo-location data point and associated physiological measurement, continuing receiving geo-location data points and associated physiological measurements, displaying a map superimposed with the stored geo-location data points graphically forming a travel route, displaying a graphical representation of stored physiological measurements having a plurality of segments each representing an average physiological measurement value, and correlating each segment in the graphical representation to points in the travel route shown on the map.

Abstract: Image analysis is performed on collected data from a person who interacts with a rendering such as a website or video. The images are collected through video capture. Physiological data is captured from the images. Classifiers are used for analyzing images. Information is uploaded to a server and compared against a plurality of mental state event temporal signatures. Aggregated mental state information from other people who interact with the rendering is received, including video facial data analysis of the other people. The received information is displayed along with the rendering through a visual representation such as an avatar.

Abstract: A method of identifying individuals impaired by a psychoactive substance such as cannabis. The method includes presenting monocularly to a subject being tested; to each eye separately, a sinusoidal grating pattern of fixed spatial frequency with achromatic contrast or color contrast between grating stripes being temporally alternately modulated at a temporal frequency that ranges between 10 Hz and 60 Hz with a pattern of the contrast being such that the subject being tested can see a frequency doubling in the grating pattern.

Abstract: A substance measurement device includes: a container portion configured to receive a substance; a sensing device configured to measure a property of the substance related to at least one of a flow rate of the substance into the container portion, a level of the substance within the container portion, and a volume of the substance within the container portion; and at least one shield positioned within the container portion and configured to provide at least one of: a mechanical buffer between the substance entering the container portion and the sensing device; and an electrical shield between the substance entering the container portion and the sensing device.

Abstract: A system device and method are presented for determining if cerebral blood flow autoregulation functionality has been compromised in a patient. The system includes sensors for detecting and measuring at least two physiological parameters such as oxygenation and blood pressure. The system analyzes these measurements and presents them as waveforms. Episodes of interest in each waveform are determined and compared. Any time lag between the occurrence of episodes of interest in each waveform is established and accounted for. Where there is correspondence between episodes of interest in each waveform then impairment of cerebral blood flow autoregulation is likely.

Abstract: A system configured to monitor autoregulation includes a medical sensor configured to be applied to a patient and to generate a regional oxygen saturation signal. The system includes a controller having a processor configured to receive the regional oxygen saturation signal and a blood pressure signal and to determine a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal. The processor is also configured to apply a data clustering algorithm to cluster COx data points over a range of blood pressures, identify a first cluster of COx data points that corresponds to an intact autoregulation zone for the patient, and provide a first output indicative of the intact autoregulation zone for the patient.

Abstract: Solubilizing compositions are provided. The compositions comprise at least one zwitterionic surfactant and at least one nonionic surfactant. In one embodiment, the compositions may be useful for solubilizing and remodeling and/or removing tissue on or beneath a patient's skin, optionally in conjunction with the application of energy to a region of interest on the skin. In one embodiment, at least one analyte may be collected and analyzed from the solubilized tissue.

Abstract: Methods of coaching a user of a breathalyzer to make use of correct blowing technique when blowing into the breathalyzer are provided. Methods of setting up a breathalyzer such that it adjusts a breathalyzer's parameters to account for jurisdictional variations in blood and/or breath alcohol limits and other standards are also provided.

Abstract: A surface attached cardiac function monitor and/or intervention system comprises of a cardiac support device, a cardiac function monitor device and/or intervention device. Cardiac support device is attached on an external or internal surface of a cardiac chamber and supports it. The cardiac function monitor device is connected with a biochemical and physiological sensor. The physiological and biochemical sensor transmits variations of biochemical and physiological parameters that are received by the cardiac function monitor device. The intervention device has at least one member selected from pressure intervention device, an electrical/magnetic stimulation intervention device and a medicine intervention device. This medical system of the present invention could help in diagnosis as well as treatment of the heart failure and other myocardial diseases to improve the condition of patient.

Abstract: A smart bracelet (100) is provided. The smart bracelet (100) has a length direction, and includes: a first pulse detector (12) and a blood flow sensor (11) sequentially arranged along the length direction, wherein, the blood flow sensor (11) is configured for identifying a blood flow direction and sending a blood flow direction signal; the first pulse detector (12) is configured for detecting a pulse signal. The smart bracelet (100) can intelligently detect whether it is worn on a left hand or a right hand and avoid manually input.

Abstract: A wearable cranial device has a substrate conformable to an individual's upper cranial hemisphere housing a force sensor for measuring forces associated with impacts to the exterior of the device in combination with a physiological sensor for measuring physiological data of the individual, and a transmitter for transmitting data from physiological sensor and force sensor to a remote receiver for evaluation of the individual's status.