Abstract: A system and method for mapping an anatomical structure includes sensing activation signals of intrinsic physiological activity with a plurality of electrodes disposed in or near the anatomical structure. A most recent intrinsic event at a selected time is determined based on the sensed activation signals and a persistent display of relevant characteristics is generated based on the sensed activation signals of the most recent intrinsic event. The persistent display is updated upon detection of a subsequent intrinsic event.

Abstract: Systems and methods are provided for predicting the onset of postoperative atrial fibrillation (AF) from electrocardiogram (ECG) data representing a patient. A signal processing component determines parameters representing the activity of the heart of the patient from the ECG data. A feature extraction component calculates a plurality of features useful in predicting postoperative AF from the determined parameters. A classification component determines an AF index for the patient from the calculated plurality of features. The AF index represents the likelihood that the patient will experience AF.

Abstract: A system for modulating a response signal includes functionalized particles configured to interact with target analytes, a detector configured to detect an analyte response signal transmitted from the body, a modulation source configured to modulate the analyte response signal, and a processor configured to non-invasively detect the one or more target analytes by differentiating the analyte response signal from a background signal, at least in part, based on the modulation. The analyte response signal is related to the interaction of the target analytes with the functionalized particles. In some examples, the system may also include magnetic particles and a magnetic field source sufficient to distribute the magnetic particles into a spatial arrangement in the body. The analyte response signal may be differentiated from the background signal, at least in part, based on modulation of the signals due, at least in part, to the spatial arrangement of the magnetic particles.

Abstract: Medical apparatus for diagnosing of a diseased condition of the skin of a subject. The apparatus comprises an electrically conducting probe including a plurality of electrodes, each electrode comprising a plurality of micro-needles, wherein each electrode comprises a base substrate, said micro-needles being integrally formed with said substrate and arranged in a laterally spaced relationship apart from each other and having a length being sufficient to penetrate the stratum corneum, said micro-needles being arranged with an at least partially oblique shape. Furthermore, the present invention relates to an electrode for use in the device, arrays of micro-needle and method for the diagnostics of biological conditions using impedance measurements. The diagnostics is in particular related to cancer, and preferably skin cancer, wherein skin cancer is a basal cell carcinoma, a malignant melanoma, a squamous cell carcinoma, or precursors of such lesions.

Abstract: The disclosure relates to an electrophysiological analysis system including: a series of electrodes intended to be placed in different regions of the human body; a direct current voltage source; a control device adapted (i) to selectively apply direct current pulses, generated by the voltage source, to a pair of so-called active electrodes, the active electrodes forming an anode and a cathode, and (ii) to connect at least one other so-called passive electrode with high-impedance, the electrode measuring the potential reached by the body; and a measurement device arranged to obtain data representative of the current at the cathode and the potentials on at least some of the electrodes connected with high impedance, in response to the application of the pulses, which data can be used to determine a value for the electrochemical conductance of the skin.

Abstract: An electrical impedance measuring apparatus includes: a plurality of electrodes adhered to a periphery of a chest of a living body; a potential measurer configured to perform a process of applying a current to any ones of the electrodes, and measuring potentials by means of other electrodes; an impedance acquirer, based on the applied current and the potentials obtained by the potential measurer, configured to obtain information related to an impedance of each of meshes, a chest section divided into the meshes; and an average value calculator configured to obtain a whole-region average value of impedances of all meshes of the chest section, and configured to obtain an ROI average value of impedances of meshes contained in each of ROIs, a whole region of the chest section segmented into the ROIs.

Abstract: An electrical impedance measuring apparatus includes: a plurality of electrodes adhered to a periphery of a chest; a potential measurer configured to perform a process of applying a current to any ones of the electrodes, and measuring potentials by means of other electrodes; an impedance acquirer, based on the applied current and the potentials measured by the potential measurer, configured to obtain an impedance of each of meshes, a chest section divided into the meshes; a histogram producer configured to set, in the chest section, at least one ROI including from a ventral side to a dorsal side, and configured to obtain a histogram of an impedance distribution in the ROI; and a producer configured to produce a color impedance distribution map in which amplitudes of the histogram are replaced with corresponding colors.

Abstract: In a magnetic resonance (MR) imaging method and apparatus, multiple diagnostic scans are obtained of an examination subject during an imaging session. An initial reference scan of the subject is obtained at the beginning of the session and, as the session proceeds, an automatic determination is made before each diagnostic scan is obtained as to whether the immediately preceding reference scan is still valid, primarily be checking whether an amount of patient movement has occurred that renders the immediately preceding reference scan invalid. Either a new reference scan is obtained before the next diagnostic scan, or, if still valid, the immediately preceding reference scan is used for the next diagnostic scan.

Abstract: A surgical system includes a flexible steerable needle and a shape sensor for measuring the shape of the needle. The surgical system can be manual (e.g., laparoscopic), robotic, or any combination of the two. By directly measuring the shape of the needle, complex and potentially inaccurate modeling of the needle to determine trajectory and insertion depth can be avoided in favor of much more robust direct measurement and modeling of needle shape and/or pose.

Abstract: A system and method monitoring conditions of a subject's body including a control unit receiving image data and data indicative of an external stimulation applied to the body during collection of the image data therefrom, a memory utility, and a processor utility. The image data is indicative of a sequence of speckle patterns generated by the body according to a certain sampling time pattern.

Abstract: This disclosure relates to methods and apparatus for detecting respiratory rate. The method for detecting respiratory rate may include: sampling respiratory waveform data in a time sequence; detecting respiratory cycles from the sampled respiratory waveform data; calculating variation degree for the sampled respiratory waveform data; calculating base length base on the variation degree; calculating smoothed length base on the base length; calculating real-time degree for each respiratory cycle base on the variation degree, sequence number of each respiratory cycle, and the smoothed length; and calculating respiratory rate base on the smoothed length and the real-time degree.

Abstract: A system for sampling exhaled breath and for supply of a gas, the system comprising: a gas delivery cannula comprising at least one nasal prong for insertion into a nostril, the nasal prong comprising a distal end; an exhaled breath sampling cannula for insertion into the nostril, the exhaled breath sampling cannula comprising a distal end; and a connector for coupling the gas delivery cannula to the exhaled breath sampling cannula, such that the distal end of the exhaled breath sampling cannula is disposed deeper in the nostril than the distal end of the nasal prong, to reduce dilution of sampled exhaled breath by delivered gas. The connected is configured to facilitate adjustability of an insertion depth of the exhaled breath sampling cannula into said nostril.

Abstract: A method for extending an effective working range of an analyzer for measuring an analyte in a breath sample. The method includes initiating a reaction in the analyzer that produces an optically discernable reaction product having an optical property that is indicative of a concentration of the analyte in the breath sample, taking a first reading of the optical property at a first time, and comparing the first reading to a reference. If the comparison yields a first state, the method includes determining the concentration using the first reading. If it yields a second state different from the first state, the method includes taking a second reading of the optical property at a second time, and determining the concentration of the analyte using the second reading. Other methods are provided as well.

Abstract: Disclosed herein are devices, methods and systems for monitoring and detection of pressure on a part of a body of a user. In an embodiment, a device includes a substrate having a contact surface for contacting a user, one or more sacs associated with the contact surface of the substrate, and one or more sensors in communication with the one or more sacs, the one or more sensors adapted to measure changes in pressure in the one or more sacs. The sacs contain a fluidic material configured to transmit pressure. The fluidic material is further configured to be shock-absorbing and pressure-relieving such that the fluidic material is displaceable by an action of the user contacting the contact surface causing the pressure in the fluidic material to be redistributed.

Abstract: A system and method for measuring and analyzing locomotion is provided. The system may include a gait analysis apparatus that is configured to provide multi-dimensional measurements of the gait of an individual as the individual traverses the apparatus. The multiple dimensions may include force, space, time, and frequency. The gait analysis apparatus may be configured to provide a gait measurement processing device with the multi-dimensional measurements. Based on the multi-dimensional measurements, the gait measurement processing device may, for example, diagnose the test subject with a particular NM disease and/or injury, monitor progression of the particular NM disease and/or injury over time, and determine which measurements may be used as biomarkers to identify the particular NM disease and/or injury.

Abstract: A device for measuring the body height of a person. In the area of an inner border of a building room at least one emitter for emitting a primary signal and at least one sensor for picking up a measuring signal are arranged. The emitter, as well as the sensor, is coupled to a control device. The control device is coupled to a display device.

Abstract: New activity recognition, recording, analysis and control techniques, systems and sensors are provided. In some aspects of the invention, multiple sensory tags with unique identification and data transfer attributes, create positional, movement, orientation and acceleration data and supply it to a control system. The tags may be placed at location(s) on the user's body, clothing, personal effects, exercise equipment and other activity-relevant locations, to enhance activity recognition and mapping. For example, a specialized PDA may comprise part of the control system, and may provide, reflect and/or receive modified data signals to and from such tags. In other aspects, a system defines a personal activity space, samples data preferentially from that space, and performs a simplified form of object-recognition to determine, record and analyze personal activities. A GUI interface within the control system may also aid in recognizing and recording activity patterns, in addition to tags.

Abstract: The analyte concentration, such as glucose, in a human or animal body is measured with an implantable sensor that generates measurement signals. The measurement signals are compressed through statistical techniques to produced compressed measurement data that can is easier to process and communicate. A base station carries the implantable sensor along with a signal processor, memory, and a transmitter. A display device is also disclosed that can receive the compressed measurement data from the base station for further processing and display.

Abstract: A body-mountable device may include a first polymer layer, a second polymer layer, and a structure that includes a sensor between the first and second polymer layers. Forming the body-mountable device may involve positioning the structure on the first polymer layer and then forming, in a molding piece, the second polymer layer over the structure positioned on the first polymer layer. The molding piece includes a surface that supports the second polymer layer as the second polymer layer is being formed and a protrusion that extends from the surface to the sensor through the second polymer layer as the second polymer layer is being formed. The body-mountable device that is removed from the molding piece has a channel to the sensor formed by the protrusion.

Abstract: A method for performing an assay to determine the presence or concentration of an analyte contained in a sample of body fluid by using a device comprising at least one analyte quantification member and a sensor associated therewith, the method includes: applying a first sample to the analyte quantification member; and detecting the presence or absence of an adequate sample volume; wherein upon detection of the absence of an adequate sample volume, initiating a finite timed period, and signaling the user to introduce a second sample of body fluid to the analyte quantification member. Associated arrangements and devices are also disclosed.

Abstract: A glucose sensor comprising an optical energy source having an emitter with an emission pattern; a first polarizer intersecting the emission pattern; a second polarizer spaced a distance from the first polarizer and intersecting the emission pattern, the second polarizer rotated relative to the first polarizer by a first rotational amount ?; a first optical detector intersecting the emission pattern; a second optical detector positioned proximal to the second polarizer, the first polarizer and the second polarizer being positioned between the optical energy source and the second optical detector, the second optical detector intersecting the emission pattern; a compensating circuit coupled to the second optical detector; and a subtractor circuit coupled to the compensating circuit and the first optical detector.

Abstract: A method and system for distributing contacting information between applications is provided. The system preferably uses an ENUM-type protocol and a middleware tool kit to associate telephone numbers to other identifying information, such as e-mail addresses or URLs for web sites. The system enables the associated contacting information to be shared across multiple applications that may be implemented on a computer or a mobile telephony device. Information is shared only after verification that a requester is authorized to receive the requested contacting information.

Abstract: An attenuated total reflection (ATR) spectroscopic analysis apparatus includes an ATR prism including: an upper surface that contacts a specimen, a lower surface facing the upper surface, a first surface that is slanted and connected to the upper surface and the lower surface, and a second surface that is slanted and connected to the upper surface and the lower surface and facing the first surface; a light source configured to emit a light towards the first surface of the ATR prism; a light receiver that is provided to face the lower surface of the ATR prism and configured to receive the light that is diffusely reflected and output from the lower surface and output an electrical signal based on the received light; and a computation processor configured to calculate a contact area of the specimen with the upper surface of the ATR prism in response to the electrical signal.

Abstract: According to some embodiments of the present invention, a display is used to show an indication of the signal's quality. This indication of the signal's quality may be provided in a number of ways, including audibly or visually.

Abstract: A physiological trend monitor has a sensor signal responsive to multiple wavelengths of light transmitted into a tissue site. The transmitted light is detected after attenuation by pulsatile blood flow within the tissue site. A processor has an input responsive to the sensor signal and a physiological parameter output. Features are extracted from the physiological parameter output. Criteria are applied to the features. An alarm output is generated when the criteria are satisfied.

Abstract: A sensor for measuring physiological characteristics includes a circuit assembly, at least one material layer, and an adhesive layer that extends beyond an outer edge of the circuit assembly. The at least one material layer forms an adhesive edge around the perimeter of the sensor.

Abstract: An optical sensor unit (10) for measuring a concentration of a gas is provided, comprising at least one sensing layer (122) adapted to be irradiated with a predetermined radiation; at least one gas-permeable layer (121) adjacent to one side of the at least one sensing layer (122) and adapted to pass gas which concentration is to be measured through the gas-permeable layer (121) towards the sensing layer (122); a removable protective layer (150) covering at least the gas-permeable layer (121) and adapted to be removed before use of the optical sensor unit (10), wherein the optical sensor unit (10) is adapted to measure an optical response of the at least one sensing layer (122), which optical response depends on the concentration of the gas.

Abstract: A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.

Abstract: Provided are dermal sensors and dermal sensor applicator sets to insert at least a portion of a dermal sensor into a dermal layer of a subject, as well as methods of making and using the same.

Abstract: Systems and methods of analyzing biological fluid biomarkers, calculating biomarker data, transmitting data to a transceiver device, and storing the data and/or analytics in a database and/or on at least one remote computer server.

Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample container for receiving the bodily fluid sample collected in the sample collection channel, the sample container operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the container provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the container.

Abstract: A system and method relate to receiving, by a processing device, at least one stream of data captured by at least one sensor monitoring a human subject, wherein the at least one stream of data comprises sensor measurements, comparing the sensor measurements to at least one model of a mental state to estimate the mental state of the human subject, determining whether to trigger an alarm based on the estimated mental state, and in response to determining to trigger the alarm, generating an instruction to trigger the alarm.

Abstract: A system and a method for monitoring subject's eyes are disclosed. In one embodiment, spectral profiles of a frame substantially around a subject's eye are received from an image capturing device. Further, a state of the subject's eye in the frame is detected using the spectral profiles received from the image capturing device.

Abstract: A leakage detecting implant can detect leakage of body fluid from an incision, resection, or other internal surgical site in a subject. The leakage detecting implant can include: one or more biodegradable colorant members having a tissue-contacting inner surface and an opposite outer surface; a resilient member having an inner surface coupled to the outer surface of the one or more colorant members; and a cover member having a body with an internal chamber and an opening on a tissue-contacting side, the internal chamber containing the resilient member and at least a portion of the one or more biodegradable colorant members with the tissue-contacting inner surface exposed through the opening, the cover member having an inner surface of the internal chamber coupled to an outer surface of the resilient member, the tissue-contacting side having one or more affixation surfaces adapted to be affixed to tissue of a subject.

Abstract: A headband monitoring system comprises or consists of an elastic fabric headband for fitting around an individual's head over the individual's forehead, ears and lower back portion of the head. In addition, a pedometer, a heart rate monitor and a number of sensors for detecting number of steps taken and heartbeats in given periods of time and a mini-computer having an input mechanism, data storage, central processing unit and a clock/timer for calculating distance traveled in a given period. Finally, the system includes an individual's smartphone separately disposed from the headband and a Bluetooth transmitter disposed in the elastic fabric band and wirelessly connected to the smartphone for displaying heart rate, steps taken and distance traveled on the smartphone.

Abstract: Provided are devices and methods suitable for immobilizing tissue and for use in non-invasive methods of assessing lower urinary tract symptoms as well as in surgical application.

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided.

Abstract: A system and method of detecting and classifying atrial fibrillations (AFs) monitors an electro-cardiogram (ECG) signal of the patient. Based on the monitored ECG signals, AF episodes are detected. Monitored physiological parameters are utilized to determine an activity level of the patient at the time of the detected AF episode, wherein the activity level is associated with the detected AF episode. The etiology of the detected AF episodes is classified as adrenergic if the AF episodes occur while the patient is active, and classified as vagal if the AF episodes occur while the patient is at rest.

Abstract: Methods, systems, and devices are provided for monitoring and displaying medical parameters for a patient. In one embodiment, a display screen can include information related to a physiological parameter being measured from a patient. The information can include a current value based on values of the physiological parameter gathered from the patient over a period of time. The display screen can indicate whether or not the current value is within a predetermined normal range for the physiological parameter and whether or not the current value is within a predetermined goal range for the physiological parameter. The goal range can be nested within the normal range. If the current value moves outside the normal range, an alarm can be triggered. A goal alarm can be triggered if the current value is within the normal range but falls outside the goal range.

Abstract: Provided is an intraoral sensor including an image sensor configured to bendable and to generate an electrical signal by detecting an X-ray; and a case configured to receive the image sensor and to limits a bending level of the image sensor.

Abstract: A prone CT breast x-ray imaging system is described that can image a full breast to create a conventional two-dimensional digital image in very high resolution (e.g., ?25 micron pixels). The system is capable of imaging the entire breast in three-dimensional based on multiple projection views from a one-dimensional or two-dimensional detector. Data can be acquired and reconstructed with a limited number of views from limited angles or with conventional cone beam CT algorithms. The resulting three-dimensional image enables the detection and diagnosis of fine micro calcifications and small masses as may be distributed throughout the breast, thus allowing radiologists to make an improved determination of malignancy as opposed to conventional two-dimensional digital mammography. In addition, the injection of intravenous contrast in conjunction with or without pre and post contrast subtraction imaging provides a radiologist with morphologic information on the existing tumor burden in the breast.

Abstract: A scanning assembly for a dual-modality automated biological tissue imaging device having first and second compression surfaces is provided. The assembly comprises a housing defining a scanning/compression surface, an ultrasonic transducer mounted within the housing adjacent the scanning surface for movement in a plane parallel to the scanning surface and imaging the tissue through the scanning surface, an X-ray detector mounted within the housing for forming an X-ray image of the tissue based on X-ray radiation passed through the tissue and scanning surface from an X-ray source, and a drive for moving the transducer across the scanning surface so that the transducer generates a plurality of two-dimensional ultrasound tissue images. The housing is hermetically sealed and filled with non-conductive fluid with acoustic impedance resembling that of the tissue. The scanning surface has acoustic impedance resembling that of the tissue and can substantially withstand compression forces applied to the tissue.

Abstract: A method for calculating a motion vector field (MVF) in a reconstructed CT scan image, comprises: determining a region of interest (ROI) based on a vessel centreline in a first reconstructed CT scan image, wherein a motion vector field (MVF) for the ROI is to be calculated; determining at least two time control points for calculating the MVF; calculating a motion level factor of the ROI; calculating motion amounts of the MVF corresponding to each of the time control points; determining the direction of the MVF of the ROI; and calculating the MVF of the ROI according to the motion level factor, the motion amounts of the MVF corresponding to each of the time control points and the direction of the MVF.

Abstract: Simulation-based estimation of elasticity parameters and use of same for non-invasive cancer detection and cancer staging are disclosed. According to one aspect, a method for simulation-based estimation of elasticity parameters includes constructing a 3D model of an object comprising biological tissue, the model having a first shape and an elasticity value. A simulation iteration is then performed, which includes simulating the application of an external force to the model, causing the model to have a second shape, measuring the difference between the second shape and a target shape, and determining whether the measured difference between the second shape and the target shape is within a threshold of error. If the measured difference is not within the threshold of error, the process performs additional iterations using adjusted elasticity or force values until the measured difference is within the threshold of error, at which time the final elasticity and force values are reported.

Abstract: An X-ray CT apparatus according to an embodiment includes an image processing circuit. The image processing circuit generates image data of an inside of a patient. The image processing circuit specifies a position of a tumor and a position of a surrounding site positioned in a surrounding of the tumor, from the generated pieces of image data. The image processing circuit calculates movement information related to movements of the tumor and the surrounding site, based on the specified positions of the tumor and the surrounding site. The image processing circuit calculates a relative relationship between the calculated movement information of the tumor and the surrounding site. The imaging processing circuit calculates a degree of coupling by which the tumor and the surrounding site are coupled, based on a relative relationship between the movement information of the tumor and the surrounding site.

Abstract: A method is disclosed for automatically selecting a scanning protocol for a tomographic recording of an X-ray image of a patient in that at least one patient-specific value is retrieved in the internal memory of a first computer. The patient-specific value can in particular be a measure of the anticipated X-ray absorption by the patient. The method includes automatically comparing the patient-specific value with retrievably stored reference values, wherein one scanning protocol can be associated with each reference value. Finally, a scanning protocol is automatically selected by way of the first computer using the comparison. Selection is simplified by automation of selection of the scanning protocol since no manual selection of the scanning protocol has to be made. Automatic selection of a suitable scanning protocol is also quicker than a manual selection.

Abstract: An imaging medical device includes a detector including an active material which is serviceable in a state of thermodynamic equilibrium, a primary power supply designed to supply the imaging medical device with power in an operating state, and an ancillary power supply designed to maintain a thermodynamic equilibrium in the active material of the detector in a non-operating state of the imaging medical device to keep the detector in a state of readiness. A method for operating such an imaging medical device is disclosed, wherein in the operating state, the imaging medical device is supplied with power via the primary power supply, and wherein in the non-operating state, a thermodynamic equilibrium is maintained in the active material of the detector, with power supplied by the ancillary power supply. The detector is thereby kept in a state of readiness.

Abstract: An x-ray computed tomography system (14) includes a gantry (15), a plurality of elements (18), and one or more processors (28). The gantry (15) moves to different orientations and generates x-ray data which includes image projection data at a plurality of the orientations. The plurality of elements (18) connect to the gantry and cause x-ray attenuation of the generated projection data. The one or more processors (28) are programmed to receive (60) the generated x-ray data and decompose (62) the received image projection data into indications of relative positions of the plurality of elements at different orientations of the gantry.

Abstract: The present invention relates to A system for monitoring the cardiovascular system using a heart sound, which comprises a heart sound receiving means(100) for receiving a heart sound(HS); DSP (Digital Signal Processor) module(200) for converting the heart sound(HS) received from said heart-sound receiving means(100) to a digital signal; and an arithmetic section(300) for calculating phonocardiogram(PCG) from the digital signal converted in the DSP module (200) and calculating information related to a preload or information related to a cardiac contractile force or information related to a respiratory change.

Abstract: A method of recognizing at least one moving anatomical structure using ultrasound data that operates by receiving ultrasound data (100). The ultrasound data comprises Doppler shift information which provides information descriptive of the velocity of at least one anatomical structure. The ultrasound data is first divided into a series of time frames (102). A classification is then assigned to each of the time frames using the Doppler shift information (104). The at least one anatomical structure is then recognized by using the classification of each time frame (106). This is possible, because different anatomical structures produce different patterns in the Doppler shift information.