Abstract: Transcutaneous electrical and magnetic nerve stimulation devices are disclosed, along with methods of averting imminent medical attacks using energy that is delivered noninvasively by the devices. The attacks comprise asthma attack, epileptic seizure, attacks of migraine headache, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, onset of ventricular fibrillation or tachycardia, panic attack, and attacks of acute depression. The imminence of an attack is forecasted using grey-box or black-box models as used in control theory. In preferred embodiments of the disclosed methods, a vagus nerve in the neck of a patient is stimulated noninvasively to avert the attack.

Abstract: Apparatus is provided that includes a parenchymal electrode, configured to be implanted in brain parenchyma of a subject identified as at risk of or suffering from Alzheimer's disease; and a ventricular electrode, configured to be implanted in a ventricular system of a brain of the subject. Control circuitry is configured to drive the parenchymal and the ventricular electrodes to clear a substance from the brain parenchyma into the ventricular system. Other embodiments are also described.

Abstract: A computer implemented system and method generates a patient-specific model of patient response to stimulation on a neural element basis, receives user-input of target neuromodulation sites, and, based on the patient-specific model, determines which stimulation paradigm and settings, including stimulation sites, would result in the target neuromodulation, where the stimulation sites are not necessarily the same as the resulting neuromodulation sites. The system outputs a visual representation of the stimulation sites that would result in the target neuromodulation. The system monitors a system state and/or patient state and dynamically changes which stimulation program to implement based on the state.

Abstract: One aspect of the present disclosure relates to a closed-loop therapy system for treating autonomic instability or a medical condition associated therewith in a subject. The therapy delivery system can include a sensing component, a delivery component, and a controller. The sensing component can be configured to detect at least one physiological parameter associated with autonomic instability or a medical condition associated therewith. The delivery component can be configured for implantation on or about an autonomic nervous tissue target or a spinal nervous tissue target. The controller can be configured to automatically coordinate operation of the sensing and delivery components. The controller can also be configured to deliver an electrical signal to the delivery component to modulate activity at the autonomic nervous tissue target or a spinal nervous tissue target and effectively treat autonomic instability or a medical condition associated therewith.

Abstract: An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.

Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

Abstract: A medical device system for controlling ventricular pacing therapy during cardiac resynchronization therapy that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to deliver the ventricular pacing in response to the emitted trigger signal, and a processor configured to identify a fiducial point of the cardiac signal sensed in real-time, set a window comprising a start point positioned a first distance prior to the fiducial point and an endpoint positioned a second distance less than the first distance subsequent to the fiducial point, determine a signal characteristic of the cardiac signal within the window, determine whether a P-wave is detected in response to the signal characteristic, determine whether an atrio-ventricular interval timer has expired, and emit a trigger signal to deliver the ventricular pacing timed off of the local maximum in response to the P-wave being detected and not timed off of the local m

Abstract: An apparatus comprises a stimulus circuit, a cardiac signal sensing circuit, and a control circuit. The stimulus circuit provides electrical pulse energy to a first pacing channel that includes a first left ventricular (LV) electrode as a cathode and a second pacing channel that includes a second LV electrode as a cathode. The cardiac signal sensing circuit senses cardiac signals using a first sensing channel that includes one of the first LV electrode or the second LV electrode. The control circuit includes a capture detection sub-circuit configured to: initiate delivery of electrical pulse energy to both the first pacing channel and the second pacing channel; sense cardiac depolarization of a ventricle using the first sensing channel; determine first and second cardiac capture pulse energy level thresholds for the first and second pacing channels respectively; and provide indications of the cardiac capture pulse energy level thresholds to a user or process.

Abstract: Methods and devices for stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry, an acoustic transducer and a pair of electrodes.

Abstract: A pulse generator that includes a communications module is disclosed herein. The communication module includes a transceiver and an antenna circuit. The antenna circuit includes a first pathway having a capacitor and a second, parallel pathway including a capacitor, and a resistor, and a radiating element arranged in series. The antenna circuit is tuned to have a resonant frequency corresponding to a desired transmission frequency and a bandwidth corresponding to shifts in the resonant frequency arising from the implantation of the antenna.

Abstract: The present disclosure provides systems and methods for programming an implanted device when a patient is remote from a clinician. A system includes a patient programmer configured to be operated by the patient, a clinician programmer configured to be operated by the clinician, and a remote diagnostic server configured to facilitate secure communication between the patient programmer and the clinician programmer, wherein the remote diagnostic server is configured to initiate a secure programming session between the patient programmer and the clinician programmer, receive a proposed stimulation program from the clinician programmer, transmit the proposed stimulation program to the patient programmer, receive an indication from the patient programmer that the patient has accepted the proposed stimulation program, and transmit an alert to the clinician programmer, the alert indicating that the patient has accepted the proposed stimulation program.

Abstract: This document presents a system for managing treatment for an emergency cardiac event. The system includes memory, one or more electronic ports for receiving ECG signals, and a treatment module executable on one or more processing devices. The module is configured to perform a number of transformation on portions of an ECG signal into frequency domain data, obtain one or more previous values derived from one or more time segments of the ECG, and determine, based on the frequency domain data a first value and a second value, determine a probability of therapeutic success. The module is further configured to cause one or more output devices to present an indication of the probability of therapeutic success.

Abstract: The present invention is directed toward a detection architecture for use in implantable cardiac rhythm devices. The detection architecture of the present invention provides methods and devices for discriminating between arrhythmias. Moreover, by exploiting the enhanced specificity in the origin of the identified arrhythmia, the detection architecture can better discriminate between rhythms appropriate for device therapy and those that are not.

Abstract: A coil configuration and method for transcranial magnetic stimulation enabling stimulation of deep regions of the brain without excessively stimulating the cortex is provided. The coil configuration utilizes at least one coil to produce an off-plane magnetic field to enhance the magnetic field from a top TMS coil. In one configuration three coils, referred to as the Triple Halo Coil and oriented at +30°, 0°, and ?30° relative to the plane of the TMS coil, are used. In another configuration a single variable position coil referred to as the Variable Halo Coil and positionable vertically and/or angularly is used.

Abstract: Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for a number of disorders. Described are methods and devices to treat disorders that involves no medication. Methods and devices described herein use alternating magnetic fields to gently “tune” the brain and affect mood, focus, and cognition of subjects.

Abstract: In a method for stimulation and treatment, a biological structure is stimulated by a high power time-varying magnetic field. The stimulation is followed by at least a partial muscle contraction. The methods can be used e.g. in physiotherapy, urology or urogynaecology.

Abstract: To provide a magnetic health device capable of making a variable magnetic field to effectively act. The magnetic health device includes a magnet 12 magnetized along a rotation direction, a first rotation mechanism 13 which rotates the magnet 12 around a rotation shaft 31 of the magnet 12, a second rotation mechanism 14 which rotates the magnet 12 around an orthogonal axis direction of the rotation shaft 31 of the magnet 12, and a support means 15 for supporting the magnet 12, the first rotation mechanism 13 and the second rotation mechanism 14 with respect to a human body.

Abstract: The present invention is directed to a method for whitening teeth that includes irradiating a tooth with light generated by a light source for an irradiation time period, the light having a wavelength that ranges from 375 nm to 420 nm and the light source emitting the light at an irradiance density ranging from 0.3 mW/cm2 to 20.0 mW/cm2.

Abstract: A method of treating diseased tissue while healing the wound using a diode laser which generates a beam of light having a wavelength in the visible portion of the electromagnetic spectrum (400 nm-700 nm) at a laser power of 0.001 to 12 watts, used with intermittent stops to control tissue temperature and biostimulate epithelial regeneration when used with or without substrates. A method of treating diseased tissue using a laser light in the green wavelength range (520-570 nm) at a laser power of 0.001 W to 5 W. A method of treating diseased tissue using a laser light in the IR wavelength range (700-1400 nm) at a laser power of 0.001 W to 5 W.

Abstract: A retainer, system and method of tattoo removal including treating a tattooed region of skin with an oxidizing or bleaching solution activated by certain wavelengths of light may be provided. The method of tattoo removal may include applying a layer of removal solution to a tattooed region of skin; regulating a temperature of the layer of removal solution with a temperature control element; and exposing the layer of removal solution to a light source of pre-determined wavelength. Light of certain wavelengths may improve or “supercharge” the effects of certain pharmaceuticals or target chemicals and agents, creating a synergistic effect that may break down tattoo ink molecules and eliminate the appearance of tattoos in the skin of humans or other animals.

Abstract: Systems and methods for generating a radiation therapy treatment plan by using ultrasound images are disclosed. The method comprises obtaining a first set of image data representing a first image of an anatomical region that includes a treatment applicator inserted into the anatomical region. The method further comprises receiving tracking information indicating a position of the treatment applicator as represented in the first set of image data, obtaining a second set of image data representing a second image of the anatomical region, and combining at least a portion of the first set of image data with the second set of image data. One of the first set and the second set of image data is used to identify a target tissue portion in the anatomical region. The method further comprises generating, based on the combined image data, treatment plan information for treating the target tissue portion in the anatomical region.

Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.

Abstract: In a combined MRI and radiation therapy system, a magnet structure and radiation therapy equipment are provided. The magnet structure comprises a single substantially cylindrical field coil structure comprising a number of superconducting coils joined by a support structure and extending axially of a central region. An outer vacuum chamber encloses the field coil structure in an evacuated volume. A cooling arrangement comprising cooling tubes is in thermal contact with the superconducting coils and receives a cryogen flowing through the cooling tubes. The radiation therapy equipment comprises a gamma radiation source rotatable about an axis of the field coil structure to direct a radiation beam substantially radially through the field coil structure.

Abstract: The present invention provides a medical apparatus (100) comprising a magnetic resonance imaging system (110) for acquiring magnetic resonance data from an imaging volume (122) covering at least partially a subject of interest (120), wherein the magnetic resonance imaging system (110) comprises a main magnet (112) for generating a magnetic field within the imaging volume (122), a particle beam apparatus (150) having a particle beam line (152) for a particle beam (154) of charged particles, including a gantry (156) configured for rotating around a rotational axis (R), which is arranged in the longitudinal direction of the main magnet (112), wherein the gantry (156) comprises at least one bending magnet (158) for directing the particle beam (154) to an irradiation volume (124) within the imaging volume (122), an active compensation coil (200), which is arranged to substantially surround at least the imaging volume (122), and a control unit (132) for controlling the active compensation coil (200) for canceling a

Abstract: Some embodiments of the present invention provide a 2D position-sensitive detector assembly comprising at least three substantially planar detector portions arranged in overlapping relationship as viewed normal to a plane of the detector portions, each detector portion comprising an array of substantially parallel, linear detector elements, the detector elements of respective detector portions being mutually non-parallel, the detector elements each being configured to generate one or more electrical signals in response to interaction of a particle of radiation therewith.

Abstract: Some embodiments of the present invention provide apparatus having a particle beamline for passage of charged particles of radiation therealong, comprising: a first beam tracker structure comprising at least one position sensitive detector (PSD) for determining a location with respect to a cross-sectional area of the beam line at which particles pass through the PSD; energy discrimination apparatus for determining an energy of particles that have passed through the first beam tracker structure; and support means for supporting a subject in a path of a particle along the beamline between the first beam tracker structure and the energy discrimination apparatus, the apparatus being configured to be operated in a selected one of a first mode and a second mode, the apparatus being configured, in the first mode of operation, to control an energy of the beam of charged particles passing through the first beam tracker structure such that a Bragg peak of charged particle absorption is located within the subject, and i

Abstract: A therapeutic ultrasound breast treatment device (101) is disclosed. The device (101) can include a receptacle (130) to receive a breast of a patient therein. The device (101) can also include an ultrasound transducer assembly disposed proximate the receptacle and oriented to direct a high intensity ultrasound transmission through an opening (168) of the receptacle (130) toward the breast. The device (101) can include a liner (1 60) disposed in the receptacle (130) to contain an ultrasound coupling fluid about the breast. The liner (160) can have an extension portion that extends through the opening (168) to form a seal with the ultrasound transducer assembly to prevent leakage of the ultrasound coupling fluid. A focus location of the ultrasound transmission can be adjustable and the device (101) can include a plurality of RF tracking coils to determine the focus location of the ultrasound transmission to facilitate adjustment of the focus location in an MRI environment.

Abstract: Apparatuses for identifying nerve tissue and methods for making and using the same are disclosed. An example apparatus may include an elongate shaft having a distal region configured to be percutaneously deployed within a patient. An active imaging structure may be disposed on the distal region. The active imaging structure may be configured to remotely image nerve tissue by exciting a signal in nerve tissue from a percutaneous location and receiving the signal from a percutaneous location. The active imaging structure may include one or more probes.

Abstract: Systems and methods for a graphical user interface for an ablation procedure include a display, a controller in electronic communication with the display, a catheter coupled to the controller, and a graphical user interface generated by the controller and shown on the display. The catheter has a distal tip comprising an ultrasound transducer. The ultrasound transducer is configured to emit an ultrasound beam. The graphical user interface includes a three-dimensional anatomical reference map of a chamber of body tissue to be ablated, where a lesion path is superimposed on the anatomical reference map; a catheter position relative to the chamber; and a window showing data. The data includes at least one of a) a distance between the ultrasound transducer and a surface of the body tissue, b) a dosing plan, c) a tissue thickness, and d) a tissue property.

Abstract: A firefighter's protective garment including an outer shell, moisture barrier and thermal barrier in which the composite structure varies according to the sweating cartography of the human body and in so doing enhances the evacuation of metabolic heat.

Abstract: A firefighter's protective garment including an outer shell, moisture barrier and thermal barrier in which the thermal barrier is constructed with spacers on its inner surface such that air can circulate between the garment and the firefighter wearing it. The garment redistributes metabolic heat over a larger surface area, and increases metabolic cooling and firefighter comfort. In the preferred embodiment of the invention, the spacers are strategically attached to those areas of the thermal barrier which find themselves opposite those parts of the human body having the highest rates of perspiration and metabolic heat transfer.

Abstract: Disclosed is a protective hood for use in protection against fire, chemical and/or biological threats, and other similar harmful environments to which individuals may be exposed under a variety of extreme conditions. The hood includes a flap that is partially separable from the remainder of the hood, where the flap includes a port for receiving a protective mask. Protective garments including the hood are also disclosed.

Abstract: Discloses a respiratory device comprising a mask positioned around the mouth and nose of a wearer to form a relative closed area sealed from the ambient air, at least one unidirectional valve for mounting of an active venting system, installed onto the mask for exhausting warm, moist exhaled air from the interior space of the respirators and at least one active venting system attached onto the valve and operated during the exhalation cycle. The top housing of the unidirectional valve has an attachment member for attaching the active venting system onto it. The active venting system can be attachable or detachable onto the valve. The valve attached with active venting system together effectively and quickly exchanges the air from the interior of the mask during exhalation cycle. When the AVS is not attached onto the valve, a simple valve cap can be attached on instead, for aesthetic purposes.

Abstract: A self-rescuer device comprises an intake pump that creates a gas stream. The gas stream enters a first sieve that separates carbon dioxide, carbon monoxide, and oxygen from the gas stream to create a mixture. The remaining gas stream flows to a second sieve that separates nitrogen from the remaining gas stream and vents the residual gas to outside of the self-rescuer device through a residual output. The separated mixture is directed to a gas processor separates the oxygen from the mixture. A nitrogen storage canister coupled to the separated output of the second sieve stores the separated nitrogen, and an oxygen storage canister coupled to the separated output of the first sieve stores and concentrates the separated oxygen until a purity threshold is met. Habitable nitrogen and oxygen are metered from their storage canisters and supplied to a user of the device through a breathing mask within an exterior mask shell.

Abstract: Nose apparatus having two flat oval replaceable filtering inserts connected to each other, characterised in that it has an external flexible carrying frame (1) in the shape resembling reversed letter V matching and adjusted to be fixed on the nasal bridge, to the bottom ends of which are fixed horizontal clamps (3) of the filtering inserts (4) and vertical elements (2) adjusted to be placed inside the nasal openings, where the clamps (3) with the filtering inserts (4) fit tight on the outside of the nasal openings, and the bottom ends of the flexible carrying frame (1) together with the vertical elements (2) form clasps on the nostrils.

Abstract: Harnesses are disclosed that comprise a back, a flexible load-bearing member and a side connection arrangement, in which each side connection arrangement includes a base that is fixed to the back and a primary connection element removably connected to the base, in which the flexible load-bearing member is connected to the connection element such that upon removal of the connection element from the base, the load-bearing member can be removed from or connected to the connection element.

Abstract: Fall protection apparatus includes a self-retracting lifeline, a tether line and a link member enabling connection of the self-retracting lifeline to the tether line. An anti-connection device is fitted to the link member permitting connection to the self-retracting lifeline but inhibiting connection to other devices when connected to the self-retracting lifeline.

Abstract: A fire suppression system according to various aspects of the present technology is configured to deliver a fire suppressant material in response to a detected fire condition in a transportable container. In one embodiment, the fire suppression system comprises a detection system adapted to generate a detection signal when exposed to a fire condition that triggers a deployment valve to release a fire suppressant material into the transportable container. The fire suppression system is also be configured to be selectively disarmed to prevent actuation of the deployment valve in the event of an inadvertent signal generated by the detection system.

Abstract: Fire protection systems and methods for ceiling-only high-piled storage protection. The systems include a plurality of fluid distribution devices disposed beneath a ceiling and above a high-piled storage commodity having a nominal storage height ranging from a nominal 20 ft. to a maximum nominal storage height of 55 ft. and means for quenching a fire in the storage commodity. The stored commodity to be protected may include exposed expanded plastics. The fluid distribution devices include a frame body having an inlet, an outlet, a sealing assembly, and an electronically operated releasing mechanism supporting the sealing assembly in the outlet.

Abstract: A continuous fire suppression system includes a fire suppressing vapor cooking medium circulating within a cooking chamber of a spiral oven; a temperature analyzer arranged to monitor a temperature of the fire suppressing vapor cooking medium; finned heating elements in communication with the temperature analyzer and arranged to heat the fire suppressing vapor cooking medium; a humidity analyzer arranged to monitor a relative humidity of the fire suppressing vapor cooking vapor medium; and a fire suppressing vapor cooking medium injector in communication with the humidity analyzers. the at least one fire suppressing vapor cooking medium injector arranged to inject the fire suppressing vapor cooking medium into the cooking chamber as needed to maintain a relative humidity equal to or greater than a relative humidity of no more than 10% vol. dry air with the remaining volume being the fire suppressing vapor cooking medium.

Abstract: The present invention is a mixing device for producing compressed foam for an extinguishing device for firefighting comprising a foam solution inlet that is operatively connected to a foam solution mixture area that is operatively connected to a compressed air inlet that is operatively connected to a compressed air injection manifold that is operatively connected to a mixing chamber. The compressed air injection manifold having a plurality of lateral sides that have a plurality of holes distributed across at least one of the lateral sides. A scrubbing collector pipe that extends into the mixing chamber to form an annular flow area within the mixing chamber. The scrubbing collector pipe having a plurality of holes distributed around an outer periphery of the scrubbing collector pipe. An inner collector pipe within the scrubbing collector pipe. A compressed air foam outlet operatively connected to the scrubbing collector pipe.

Abstract: Systems and methods for determining the accuracy of a foam addition system on a firefighting vehicle are disclosed. The methods may include measuring the amount of a test water stream flowing through a foam metering device.

Abstract: A trampoline including: a frame adapted to rest on the ground or be mounted on a plurality of spaced apart legs; a plurality of spaced apart flexible and resilient plates extending upwards from said frame and connected thereto against relative movement therebetween; and a jumping mat operatively connected to said plates above said frame for movement with said plates upon a person jumping thereon.

Abstract: A lower extremity mobilizer for use in rehabilitation is provided. A seat is slidably maintained upon a base, with a foot support brace being provided at an end of the base to receive the foot of a leg provided for arthrokinematic treatment. A cord and pulley system is provided between the seat and the end of the base. In use, a patient is seated with a foot received by the foot support brace. The patient provides arthrokinematic motion to his leg by pulling himself and the seat toward the end of the device having the foot support brace. The procedure is undertaken in a closed chain motion, with the foot constantly engaging the foot support brace, and is done so as a rate, timing and extent under the control of the patient.

Abstract: A modular exercise system is described wherein the system utilizes a universal hydraulic actuator attached to a mount. A connector is attached to the universal hydraulic actuator opposite the mount. The universal hydraulic actuator preferably comprises two hydraulic rotary actuators with non-parallel axis of rotation.

Abstract: A resistance component configured for imparting a resistive force to a connected exercise component is provided. The device includes a frame pivotally supporting a selection arm which has a weight operatively connected to the selection arm by a pin arm. The weight imparts a force resisting rotation of the selection arm by a flexible member engaged with the exercise component. Adjusting the engagement of one end of the pin arm to an arched engagement path along the selection arm adjusts mechanical advantage and the resistive force.

Abstract: An exercise biased weight includes a weight body defining a center of mass and a through offset bore formed at the weight body at a position offset to the center of mass thereof, wherein a diameter of the offset bore is slightly larger than a diameter of a weight bar member for enabling the weight bar member to slidably pass through the offset bore so as to retain the weight body at the weight bar member. Therefore, the weight body is lifted to generate a downward weight force to against an unwanted shaking movement of the weight body.

Abstract: An embodiment apparatus includes a crossbar including a surface with holes arranged along a portion of the crossbar and a handle including a surface with a hole. The crossbar may be configured to allow the handle to positionally adjust along the portion of the crossbar such that the hole in the surface of the handle aligns with one of the holes in the surface of the crossbar when the handle is located at a position along the portion. Alternatively or in addition, the handle may include a head which defines a plurality of holes in the handle. In this arrangement, a first connector is configured to slidably engage one of the plurality of holes in the handle and the hole in the crossbar, each of the plurality of holes in the first handle defining an orientation of the first handle.

Abstract: An apparatus for improving flexibility and its method of use are provided. The apparatus features a flexible member, which can have varying degrees of stiffness and flexibility, based on user preference. Further, the apparatus features a first and second auxiliary grip, as well as a first and second primary grip. In conjunction, these grips provide a vast multitude of ways to grip the apparatus, enabling it to be used in a wide variety of stretches and exercises, promoting strength as well as joint mobility and flexibility.

Abstract: An exercise machine inclination device for providing variable exercise intensity on an exercise machine by inclining the exercise machine. The exercise machine inclination device generally includes a base adapted for being positioned upon a floor, a support structure adapted for supporting an exercise machine, a hinge pivotally connecting the base and the support structure and an actuator connected between the base and the support structure, wherein the actuator adjusts an angle of the support structure.