Abstract: A computer implemented method for decomposing a layout of a portion of an integrated circuit is presented. The layout includes a first multitude of polygons. The method includes constructing, using the computer, a first matrix representative of a first multitude of constraints. Each of the first multitude of constraints is between a different pair of the first multitude of polygons. The method includes solving, using the computer, the first matrix to thereby assign one of a multitude of masks to each different one of the first multitude of polygons, when the computer is invoked to decompose the layout.

Abstract: A method of manufacturing a gas turbine engine including designing a row of vanes provided upstream of an asymmetric gas flow volume. The method includes two dimensionally optimising camberline and stagger angle of each vane, including using orthogonal polynomials to modify the camberline and stagger angle of each vane.

Abstract: Systems and methods are proposed for synthetic biology design and host cell simulation. In one form, a synthetic biology design system is proposed, comprising a model conversion component configured to: receive genetic circuit data indicative of a user-specified genetic circuit design; identify, from the genetic circuit data, constituent parts of the genetic circuit design, and the connections between the constituent parts; obtain mathematical models corresponding to the constituent parts; and combine the obtained mathematical models into a composite model configured to generate genetic circuit output data based on input data indicative of one or more of: free RNA polymerase concentration, free ribosome concentration and rRNA concentration.

Abstract: A computing system automatically analyzes various drug or other compound targets using biologic activity data for cellular proteins, and develops a target/anti-target matrix identifying pharmacologically responsive targets intended for drug engagement, and pharmacologically responsive anti-targets intended for avoidance of drug engagement. The system separates compounds into subsets based on biological threshold data and groups proteins through pharmacological similarity. The system ranks protein groupings in generating the matrix and uses the rankings to recommend compounds and compound groupings for testing to treat a pathology. The system compares new compounds against the matrix to recommend new compounds for testing.

Abstract: A system for analyzing sequencing data of bacterial strains and a method thereof are provided. The method for analyzing sequencing data of bacterial strains includes the following steps: searching a specific variable region of a first genetic sample sequence and searching another specific variable region of a second genetic sample sequence; determining whether both the specific variable region and the another specific variable region have an identical cross-sample subsequence; if both the specific variable region and the another specific variable region have the identical cross-sample subsequence, storing the cross-sample subsequence into a recording table; and if the identical cross-sample subsequence exists, comparing the cross-sample subsequence with a plurality of gene sequences of known strains stored in a database module to analyze a plurality of strains corresponding to the cross-sample subsequence in the first genetic sample sequence and the second genetic sample sequence.

Abstract: The present invention provides a selection method of tag SNPs, for constituting a group of nucleic acid probes corresponding to the tag SNPs, the tag SNPs being used for performing imputation of information on SNPs of human genome by using human genome information, the human genome information including information on a group of SNPs, the genotypes of the SNPs being identified in multiple individuals, in which method a sum of mutual informations between tag SNP candidates and target SNPs is used as an index for selecting the tag SNPs, and a computer system based on the principle, a computer program, and a DNA microarray on which nucleic probes corresponding to the tag SNPs selected by the means, and a production method thereof.

Abstract: A method for determining a sequence of a target nucleic acid is described. The method uses a plurality of control oligonucleotides with known sequence and unique identifications to map hybridization signals associated with a plurality of sequencing probes to a loosely packed multi-dimensional dye space, such that a region in the dye space can be associated with one or more sequencing probes. When a detected target hybridization signal of a sequencing probe and a target nucleic acid is mapped to the multi-dimensional dye space, the sequencing probe and thus the corresponding nucleotides in the target nucleic acid can be determined based on the one or more sequencing probes associated with the region that the detected target hybridization signal is mapped to.

Abstract: Systems and methods to characterize one or more microorganisms or DNA fragments thereof are disclosed. Exemplary methods and systems use comparison of DNA sequencing information to information in one or more databases to characterize the one or more microorganism or DNA fragments thereof. Exemplary systems and methods can be used in a clinical setting to provide rapid analysis of microorganisms that may be a cause of infection.

Abstract: The invention relates to a method for producing polymers, in particular synthetic nucleic acid double strands of optional sequence, comprising the steps: (a) provision of a support having a surface area which contains a plurality of individual reaction areas, (b) location-resolved synthesis of nucleic acid fragments having in each case different base sequences in several of the individual reaction areas, and (c) detachment of the nucleic acid fragments from individual reaction areas.

Abstract: The present disclosure relates to systems and methods for facilitating trusted handling of genomic and/or other sensitive information. Certain embodiments may use a virtualized execution environment to execute code and/or programs that wish to access and/or otherwise use genomic and/or other sensitive information. In some embodiments, data requests from the code and/or programs may be routed through a transparent data access proxy configured to transform requests and/or associated responses to protect the integrity of the genomic and/or other sensitive information.

Abstract: An apparatus that can measure images of at least a portion of an eye and record data sets indicative of a neurological condition. A method interrelates an image and a data set to provide an interpretive result. The apparatus and method thereby provide guidance as to the presence of a medical condition in a patient. The apparatus and method can be used in an iterative measurement process, in which the apparatus attempts to discern normal health from a state of health that is not normal health. If the interpretive result is consistent with normal health, the process terminates, information is recorded, and an optional report is given. If the interpretive result is not consistent with normal health, the apparatus and method attempts to distinguish which condition is consistent with the data and images used, and can iterate with additional measurements and information to attempt to provide a useful interpretive result.

Abstract: Systems and methods are disclosed for documenting a narrative patient visit note. A user input is received and is associated with narrative phrases which are converted to narrative sentences. These sentences, constructed by the system, are then arranged to form a narrative patient visit note. The narrative patient visit note is constructed in such a manner as to be exportable to numerous electronic medical record systems.

Abstract: A health data management device includes a communication unit that receives index data based on a result of measurement from a measuring device for measuring biological information and activity information of a person to be measured, through wireless communication, a storage unit that stores a database for managing the received index data, a display unit that displays index data managed in the database, in a predetermined displaying way, and a control unit that controls an image displayed on the display unit. The control unit causes an index panel of each index data to be displayed on the display unit, for at least a part of the index data managed in the database. The index panel is an icon showing a value of each index data.

Abstract: Provided are a search method and device in which, in order to search for health data having a multivariate (multi-dimensional) time-series characteristic with high calculation complexity for a search, a format of the health data is converted and a dimension of the health data is reduced through feature extraction to which a learning model is applied, so that the calculation complexity for the search may be remarkably reduced and the similar case search may be performed efficiently.

Abstract: Certain aspects of the disclosure are directed to an apparatus including a scale. The scale includes a platform in which a plurality of electrodes are integrated and configured and arranged for engaging a user and processing circuitry. The processing circuitry is electrically integrated with the plurality of electrodes to process user-corresponding data with physiologic parameter data obtained while the user is standing on the platform and therefrom derive and output derivation data indicative of a physiologic status of the user for assessment of a condition or treatment of the user that corresponds with the physiologic status, and store, in response to the derived derivation data, additional data in the memory circuit to supplement the user-corresponding data with information corresponding to the physiologic parameter data obtained while the user is standing on the platform.

Abstract: Provided are a personal cloud based personal health record management method and device for allowing users to dominantly manage personal health records, which are accumulated and managed by each of various health service institutions, through a personal health record management device and a personal cloud repository.

Abstract: A wearable scribing system includes a camera and a microphone which communicate information to a remote system via a receiver/transmitter device. A scribe at the remote system inputs the information into an electronic health record. The wearable scribing system enables direct physician to physician communication.

Abstract: Systems, methods, and computer-readable medium are provided for managing user information. For example, subscription information may be received from an application that identifies a data type associated with information of a user. The application may be launched as a background process at least in response to receipt of a portion of the information that corresponds to the data type.

Abstract: Digital assistant systems and methods include computerized displays that display timelines of healthcare instances based on date of the same. Timelines may display unique sets of healthcare instances based on selected nodes, filters, or other criteria such as allergies, prognosis, medications, or vitals. Digital assistant systems and methods provide single-page displays of timelines that can be sorted and filtered based on user engagement with the same. Additional information can be recorded through selection and filtering of timelines during specific interactions and times, associated with the recordation, through the single page.

Abstract: A perioperative healthcare management system accessible by a plurality of healthcare providers to collect information related to a patient includes a processor, a database for storing data related to a plurality of patients, and a memory coupled to the processor. The memory is configured to store program instructions executable by the processor, and, in response to executing the program instructions, the processor is configured to generate a dashboard including a plurality of regions, each region corresponding to one of a plurality of modules of perioperative care.

Abstract: Methods and devices are provided for healthcare action sequencing and record keeping. The method may involve scanning a patient care area for tags for entities present in the area, a given patient being located in the area. The method may involve reading identity data from a tag, in response to detecting the tag for an entity in the area. The method may involve receiving input data regarding the given patient by a healthcare personnel via a user-interface. The method may involve communicating with a management system that includes a first database storing rules for how patients with known sets of conditions are to be cared for, a second database storing rules for how the input data are to be used, and a third database storing rules relating to procedures and restrictions for the healthcare personnel.

Abstract: Certain examples provide systems, methods, and apparatus for medical device management. An example method includes comparing a first identification of a first data set to a second identification of a second data set at a medical device. The example method includes, when the first identification does not match the second identification, triggering a download of the second data set to the medical device. The example method includes determining an operating state of the medical device. The example method includes, when the operating state indicates the medical device is idle, triggering activation of the second data set in place of the first data set at the medical device. The example method includes facilitating operation of the medical device according to the second data set.

Abstract: A method for finding the optimal schedule and route to visit all constrained and unconstrained nodes of a graph only once while respecting the associated time windows and system constraints. The constrained nodes are first grouped in clusters based on their time windows and system constraints. Then, unconstrained nodes are optimally assigned to the clusters by using a greedy heuristic. Subsequently, enumeration is used to solve the TDTSPTW by cluster. Once all clusters are solved, the paths are joined and a local search heuristic is used to improve the solution. The result of the method is an ordered set of nodes to be visited with their associated start times.

Abstract: Systems and methods for processing a workflow are disclosed. Certain embodiments allow prescreened data to be inserted into a workflow. A user's interpretation of prescreened data can be compared with previously obtained characteristics, enabling the user's interpretive output to be monitored and improved. The disclosed systems and methods have applications including, but not limited to, training, performance analysis, process improvement, and data analysis and data mining in workflows.

Abstract: The present disclosure relates to a method and system for predicting the consultation duration for a user in a healthcare system. In an embodiment, the appointment scheduling system used in the healthcare connects with the prediction system through a communication network or directly for predicting the consultation time of a user. The prediction system receives at least one of user attributes, medical records and current symptoms of the users. The prediction system further determines the consultation preparation time and actual consultation time which is used by the prediction system for predicting the consultation duration for a user.

Abstract: A system for treatment of ischemic stroke provides a stroke treatment workflow plan defining series of diagnostic actions and therapeutic actions to be performed at locations within a health care facility identified by beacons detectable by proximity sensors that travel with the patient. A first communications device having wireless communications capabilities receives a signal from a proximity sensor and typically transmits data to a second communications device having a visible timer and configured to receive data from and send data to other wireless communications devices. When the a patient undergoes diagnosis and treatment via the workflow plan, the system tracks the location of the patient within the workflow plan and the time at which the patient is at each location, and records the location of the patient and the time of the location within the workflow plan.

Abstract: The CareMed, National Walk-In Medical Clinical Locator provide consumers global access to healthcare provider services regardless of their affiliation or membership to any one caregivers network. A single point of intelligent access removes the need for consumers to submit generic searches or make arbitrary decisions with little if any basis in fact. Additionally, it avoids the need for consumers to register or enroll in any one specific provider care network. The weighted list of provider recommendations utilizes a wide range of propriety decision-based variables to recommend services to the benefit of the consumer and facilitate inter-provider competitiveness thereby increasing the availability of care providers.

Abstract: Approaches presented herein enable performing a health analysis of a user using a smart floor mat. Specifically, a sensory array of the smart floor mat collects static and dynamic pressure data for capturing the movement and force exerted by a user's feet as the user walks across the smart floor mat. A healthcare analysis is then performed by comparing this current measurement data against the user's historical measurement data and expected results to generate a healthcare insight such as a trend, pattern, or deviation. The healthcare insight can predict or indicate a health issue. If a deviation exceeding a predefined permissible threshold exists, a healthcare professional can be notified.

Abstract: Disclosed are a method and a system using user personal, CBC, CMP and Lipid Panel data to detect a user acute myocardial infarction (AMI) risk and help user monitor AMI risk. Most AMI risk screening and diagnosis are related with the markers, video, image data, etc. although past researches have shown that serum albumin, RBC, MCV, MPV and PDW are all significantly correlated with AMI risk, use of the blood test results of CBC, CMP and Lipid Panel data to detect and monitor AMI risk has never been reported. Traditionally, AMI risk detecting and monitoring have been managed by doctors and hospitals and a user is unable to do it by himself or herself. The purpose of this invention is to provide an intelligent AMI risk detecting and monitoring system enabling users to detect and monitor AMI risk.

Abstract: Presented herein are one or more software applications to help a user manager their diabetes. Embodiments and descriptions of the various applications are provided below in conjunction with an analyte measurement device.

Abstract: When monitoring patients in a general ward, clinical decision support risk scores are evaluated to determine whether a patient should be monitored using a spot check method whereby a caregiver periodically checks the patient, a continuous monitoring method whereby the patient is monitored by a monitoring device such as an electrocardiograph, or whether the patient requires transfer to a progressive care unit (PCU) or intensive care unit (ICU). When the number of patient monitors is not sufficient to assign a monitor to all patients for whom a monitor is desired, CDS score thresholds are adjusted to ensure that the neediest patients are assigned monitors.

Abstract: Certain examples provide systems, methods, and apparatus for medical device management. An example method includes determining a role mapping for a user and determining a location mapping for the user. The example method includes generating a combined location and role mapping for the user based on the role mapping and the location mapping. The example method includes configuring user access to one or more medical devices based on the combined location and role mapping. The example method includes facilitating interaction with the one or more medical devices according to the configured user access.

Abstract: Methods, apparatuses and systems are described for associating a patient with a medical sensor. Methods may include receiving a patient identifier that is physically coupled with the patient, receiving a dynamically generated sensor identifier associated with the medical sensor, and associating the patient identifier with the sensor identifier. Methods may further include re-receiving the patient identifier after an occurrence of a disassociation event between the patient and the medical sensor, receiving an updated sensor identifier associated with the medical sensor that is different from the sensor identifier received before the disassociation event, and associating the patient identifier with the updated sensor identifier. Systems may include a medical sensor configured to collect medical data from the patient and a display unit coupled with the medical sensor and configured to display a dynamically generated sensor identifier associated with the medical sensor.

Abstract: In certain implementations, health monitoring of an individual may be provided based on an individual-specific prediction model. In some implementations, a prediction model for health monitoring may be obtained. Health information associated with an individual may be obtained. The health information may indicate a co-occurrence of health conditions of the individual. An individual-specific prediction model associated with the individual may be generated based on the prediction model and the co-occurrence indication. Subsequent health information associated with the individual may be obtained. The subsequent health information may indicate one or more of: (i) subsequent measurements of the individual observed after the co-occurrence of the health conditions; or (ii) subsequent health conditions of the individual observed after the co-occurrence of the health conditions. A health status of the individual may be predicted based on the individual-specific prediction model and the subsequent health information.

Abstract: A system for operating third party proprietary software on a medical monitoring device operating native proprietary software and a system for obtaining compatible third party proprietary software for operation on the monitoring device.

Abstract: A system and method are disclosed for computing a Health Score. Health data and extrinsic data are received that are parameters for computation of the Health Score. The received data can be combined using an algorithm being implemented as code executing in a processor so as to compute the Health Score of the individual wherein parameters comprising one portion of the data interacts with parameters comprising another portion of the data. Further, the computed Health Score is output to an interface of the user device. Information concerning the parameters' interaction are selectively output to the interface that explain which changes in the parameters are significant drivers of the change in the Health Score.

Abstract: A system for monitoring event trajectories is disclosed. The system includes one or more processors, one or more computer-readable tangible storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include first program instructions to receive data indicative of a current medical status of a patient. The program instructions further include second program instructions to retrieve data indicative a previous medical status of the patient. The program instructions further include third program instructions to calculate, based on the current medical status and the previous medical status, a trajectory representative of the patient's medical status, the trajectory comprising a magnitude and a direction. The program instructions further include fourth program instructions to communicate the trajectory of the patient's medical status.

Abstract: The inventive concept relates to a method and apparatus for predicting health data values through the generation of a health data pattern. The inventive concept provides a health data value prediction method and apparatus. The health data value prediction method and apparatus may select health data values and important health characteristics associated with the health data values from big data on a plurality of pieces of time-series health information. The health data value prediction method and apparatus may form a health data value prediction model that has repetitively learned the pattern, and accurately predict a user's health data value through the prediction model.

Abstract: A system for estimating fractional flow reserve (FFR) includes a front end application to receive image frames from an imaging system to develop a model of a vasculature system based on an observed concentration time profile at locations within the model using contrast dye in the vasculature system and movement of the vasculature system. A graphics processing unit is configured to represent a computed concentration time profile in the vasculature system using a Lattice-Boltzmann Method (LBM) to generate a representation of the vasculature system. A dynamic controller tunes a velocity field based on a mismatch between the observed concentration time profile and the computed concentration time profile at the locations within the model to obtain a best estimate of the velocity field to perform a FFR measurement.

Abstract: Described are methods for treating a patient with a therapeutic drug using a combination of genetic and non-genetic information to tailor the dose of the drug to the patient.

Abstract: Systems and methods are disclosed for simulation of occluded arteries and/or optimization of occlusion-based treatments. One method includes obtaining a patient-specific anatomic model of a patient's vasculature; obtaining an initial computational model of blood flow through the patient's vasculature based on the patient-specific anatomic model; obtaining a post-treatment computational model by modifying portions of the initial computational model based on an occlusion-based treatment; generating a pre-treatment blood flow characteristic using the initial computational model or computing a post-treatment blood flow using the post-treatment computational model; and outputting a representation of the pre-treatment blood flow characteristic or the post-treatment blood flow characteristic.

Abstract: A state-estimator for the estimation or initialization of the state of a discrete-time state-space dynamical model based on sensor measurements of the model output, comprising fitting a continuous-time function to acquired sensor measurement data-points of each model output, and subsequently sampling the continuous time function at exactly the sample-period of the state-space dynamic model for which the state is being estimated or initialized, in order to construct a model state via a synthesized output trajectory.

Abstract: A method is disclosed for automatically determining a contrast agent injection protocol for a patient to be examined. An embodiment of the method includes provisioning a plurality of patient reference parameters, a plurality of contrast agent injection protocol parameters and a plurality of assignments of at least one given patient reference parameter with at least one given contrast agent injection protocol parameter; comparing of at least one patient parameter with the plurality of patient reference parameters, the patient parameter being based on patient information; selecting at least one patient reference parameter from the plurality of patient reference parameters based on the comparing; and determining at least one contrast agent injection protocol parameter from the plurality of contrast agent injection protocol parameters.

Abstract: A prescription verification system and method is provided that stores and processes information on one or more servers for verifying medical prescription orders originating from healthcare providers. The system and method enables one or more clients to retrieve medical prescriptions and for ordering personnel information for prescription verification through the system. The system includes functionality for entering, editing, or deleting data files and retrieving and displaying them as requested by authorized users as they pertain to ordering, verifying, filling and tracking of medical prescriptions.

Abstract: A medication administration and tracking system is described. The system is equipped with an electric medication dispenser configured to administer medication to a patient in a hospital bed without intervention from hospital staff. The dispenser is configured to allocate safe doses of prescribed or over-the-counter medications to a patient upon request by the patient. At least one method of biometric authentication is employed to solely permit access to the medication to the patient upon confirmation of his or her identity. A camera disposed on the dispenser is configured to witness the patient take the medication, and track the time and date of consumption. The medications administered are preferably equipped with a tracking sensor to help track medication levels within the patient, and monitor treatment efficacy.

Abstract: A medication system includes a control module that determines when a medication is removed from a central pharmacy or a medication base station. The medication is carried by the healthcare professional and/or placed in a mobile workstation. A remote medication database, separate from a central inventory database associated with the healthcare facility, stores information about a total stock of the medication and respective stock quantities of the medication located in the central pharmacy, in the medication base station, carried by the healthcare professional, and/or placed in the mobile workstation. The total stock and the respective stock quantities are updated by the control module in response to a determination that that medication was removed from the central pharmacy or the medication base station. The control module updates the remote medication database in response to the medication being administered and updates the central inventory database.

Abstract: Devices, systems and methods for monitoring medication are provided. A medication monitoring device according to one implementation includes a container configured to store a plurality of medication pills and a gating device connected at an opening of the container. The gating device is configured to electronically monitor the release of at least one of the medication pills. A system and method for monitoring the administration of medication to a patient are also provided. The system, according to one embodiment, comprises the medication monitoring device and a medication management server in communication with the medication monitoring device via a communication network.

Abstract: Methods and systems for determining that a medical delivery device has been activated may be provided. According to certain aspects, a user captures a first image to determine if a medical delivery device is ready to be activated. The first image is transmitted to a health care provider which verifies that the medical delivery device should be activated. If the medical delivery device is to be activated, an electronic device instructs the user to activate the medical delivery device. Subsequently, the user transmits details about the activation of the medical delivery device to the health care provider to update a medical record.

Abstract: A passive tracking device, a processor configured to receive information from the tracking device, and a database accessible by the processor, among other elements, are disclosed. A first activity unit having a first start time corresponding to detection of engagement is monitored. The processor is further configured to establish a first end time of the first activity unit using the monitored information, and automatically ascribe a classification of the first activity unit. The classification of the first activity unit is output to a display of a computing device, and the classification of the first activity unit is stored in the database. A revised classification is output to a display of a computing device, the revised classification is stored in the database.

Abstract: A system for monitoring a joint of a patient includes multiple sensors to be disposed near a joint and to measure or observe actions or physical quantities associated with the joint; and at least one communications module coupled to the sensors to receive data from the sensors and to transmit sensor information to an external device. The system also includes a patient device and clinician device which can be used to, for example, monitor and display information obtained from the sensors, determine range of motion measurements from the sensor data, show progress in physical therapy, take a photograph or video of the site on the patient, obtain a pain score, and include friends for providing encouragement during physical therapy.