Abstract: Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide radiation data associated with the tumor treatment site; and (b) a first portable receiver in communication with the plurality of sensors. The receiver is configured to obtain radiation data from the sensors at a plurality of different times. The receiver is in communication with a local and/or remote computer that tracks variation in the radiation data to provide dynamic tumor site information.

Abstract: A method for real-time, high-density physiological data collection includes automatically measuring, by a wearable device, one or more physiological parameters during each of a plurality of measurement periods, and upon conclusion of a measurement period, for each of the plurality of measurement periods, automatically transmitting by the wearable device data representative of the physiological parameters measured during that measurement period, to a server, the server configured to develop a baseline profile based on the data transmitted by the wearable device for the plurality of measurement periods. The measurement periods may extend through a plurality of consecutive days, and each of the consecutive days may include multiple measurement periods. At least some of the physiological parameters are measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.

Abstract: An automated assessment of a patient's peripheral vascular condition includes using a pulse oximeter to generate at least a perfusion index relative to a limb or digit of the patient. Pressure is applied to the limb or digit, and while increasing or decreasing the pressure, a change in the perfusion index is determined. The change is indicative of a cessation of blood flow or a return of blood flow in the limb or digit. A systolic blood pressure is thereafter determined based on the pressure applied at the time of cessation of blood flow or the return of blood flow in the limb or digit. Using a pulse oximeter to generate a perfusion index may include transmitting light into the limb or digit, detecting light that was transmitted into tissue in the limb or digit, and calculating the perfusion index based on the light transmitted through the tissue.

Abstract: Because reprocessing or refurbishing of physiological sensors reuses large portions of an existing sensor, the material costs for refurbishing sensors is significantly lower than the material costs for making an entirely new sensor. Typically, existing reprocessors replace only the adhesive portion of an adhesive physiological sensor and reuse the sensing components. However, re-using the sensing components can reduce the reliability of the refurbished sensor and/or reduce the number of sensors eligible for refurbishing due to out-of-specification sensor components. It is therefore desirable to provide a process for refurbishing physiological sensors that replaces the sensing components of the sensor. While sensing components are replaced, generally, sensor cable and/or patient monitor attachments are retained, resulting in cost savings over producing new sensors.

Abstract: In some implementations, a device includes light emitter(s) to emit first light having a first wavelength and second light having a second wavelength. The device also includes light detector(s) to generate a first electrical signal while the light emitter emits the first light, a second electrical signal while the light emitter emits the second light, and a third electrical signal while the light emitter is not emitting light. The device also includes ambient light cancellation circuit(s) to generate a countering signal to counter a portion of one or both of the first and second electrical signals based on the third electrical signal. The device also includes analog to digital converter(s) to generate first and second digital signals based on values of the first and second electrical signals, respectively. The device further includes a controller to determine a saturation of peripheral oxygen metric based on the first and second digital signals.

Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have a first side edge and a second side edge. The reference electrode can be situated such that at least a portion of the first and second side edges of the working electrode are adjacent respective sections of the reference electrode.

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a membrane structure with an analyte permeability that is substantially temperature independent. The devices also include a sensing layer disposed on a working electrode of in vivo analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

Abstract: A region of skin, other than the fingertips, is stimulated. After stimulation, an opening is created in the skin (e.g., by lancing the skin) to cause a flow of body fluid from the region. At least a portion of this body fluid is transported to a testing device where the concentration of analyte (e.g., glucose) in the body fluid is then determined. It is found that the stimulation of the skin provides results that are generally closer to the results of measurements from the fingertips, the traditional site for obtaining body fluid for analyte testing.

Abstract: Foley type catheter embodiments for sensing physiologic data from a urinary tract of a patient are disclosed. The system includes the catheter and a data processing apparatus and methods for sensing physiologic data from the urinary tract. Embodiments may also include a pressure sensor having a pressure interface at a distal end of the catheter, a pressure transducer at a proximal end, and a fluid column disposed between the pressure interface and transducer. When the distal end is residing in the bladder, the pressure transducer can transduce pressure impinging on it into a chronological pressure profile, which can be processed by the data processing apparatus into one or more distinct physiologic pressure profiles, for example, peritoneal pressure, respiratory rate, and cardiac rate. At a sufficiently high data-sampling rate, these physiologic data may further include relative pulmonary tidal volume, cardiac output, relative cardiac output, and absolute cardiac stroke volume.

Abstract: The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.

Abstract: A method and system of providing therapy to a patient's uterus is provided, which can include any number of features. The method can include the steps of inserting a uterine device into the uterus and performing a uterine integrity test to determine that the uterus is intact and not perforated. If it is determined that the uterus is not perforated, a patency test can be performed to determine that the uterine device is not clogged or embedded in tissue. If the uterus is intact and the device is not clogged or embedded in tissue, the uterus can be treated with the uterine device, e.g., uterine ablation. Systems for performing these methods are also disclosed.

Abstract: A tool for recommending proper sun block use. The tool receives, by one or more computer processors, a first image of a user captured by a camera, and a second image of a user captured by a camera, wherein the first image is an ultraviolet image, and the second image is a digital color image. The tool determines, by one or more computer processors, areas of ultraviolet radiation vulnerability for the user captured in the first and second image. The tool determines, by one or more computer processors, a level of ultraviolet radiation vulnerability for the determined areas. The tool determines, by one or more computer processors, a recommendation for proper sun block use based, at least in part, on the level of ultraviolet radiation vulnerability.

Abstract: A tool for recommending proper sun block use. The tool receives, by one or more computer processors, a first image of a user captured by a camera, and a second image of a user captured by a camera, wherein the first image is an ultraviolet image, and the second image is a digital color image. The tool determines, by one or more computer processors, areas of ultraviolet radiation vulnerability for the user captured in the first and second image. The tool determines, by one or more computer processors, a level of ultraviolet radiation vulnerability for the determined areas. The tool determines, by one or more computer processors, a recommendation for proper sun block use based, at least in part, on the level of ultraviolet radiation vulnerability.

Abstract: A pain sensory nerve stimulation apparatus includes: a stimulation electrode which is adapted to be attached to a living body, at least one of an exogenous algesic substance and pyrogen which is to be interposed between the living body and the stimulation electrode; and a stimulation power supplier which is configured to supply electric power to the stimulation electrode.

Abstract: A data processing method for planning a medical treatment comprising following steps performed by a computer: acquiring reference patient data describing medical information on at least one reference patient including information on progression of the medical constitution of the at least one reference patient; acquiring current patient data describing medical information on a current patient; determining information on the progression of the medical constitution of the current patient based on the reference patient data and the current patient data.

Abstract: A method and system for monitoring a user's intoxication including receiving a set of signals, derived from a set of samples collected from the user at a set of time points; providing a sobriety task to the user proximal to a time point of the set of time points; generating a performance dataset characterizing performance of the sobriety task by the user; receiving a supplementary dataset characterizing a demographic profile of the user and/or a physiological state of the user; determining a set of values of an intoxication metric, derived from the set of signals; generating a predicted temporal profile of the intoxication metric for the user based upon the set of values, the set of time points, and the supplementary dataset; generating an analysis of the user's sobriety based upon the performance dataset and the predicted temporal profile; and providing a notification to the user based upon the analysis.

Abstract: A sensor system for sensing a stimulus in vivo includes an implantable sensor. The sensor comprises a passive resonator circuit having a resonant frequency and including at least a pair of generally parallel spirally wound unconnected conductive coils sandwiching a layer of solid dielectric material that manifest a change in property affecting the resonant frequency in response to application of the stimulus to the layer. A resonant frequency of the sensor is modulated by altering the spacing or gap between the coils or altering the overlapping area of the coils. The sensor is energized through application of radiofrequency energy and the responding resonant frequency is detected. The sensor can be advantageously attached to a medical implant to form a practical smart implant for clinical purposes.

Abstract: The invention relates to a system (100) for sensing ambient light intensity, comprising a wearable device (10) with at least one pair of light receivers (20, 22, 23, 24, 25) arranged in two different positions for receiving light from the two different directions, and a control unit (110) configured to determine a directional illuminance based on light intensities of the light received by the pair of light receivers (20, 22, 23, 24, 25).

Abstract: The invention is related to a medical device for conducting a medical examination and/or intervention within a human or animal body the medical device (1) comprising an elongate body (2) which is designed for introduction into an orifice (15) of the human or animal body the elongate body (2) comprising a distal end (3), which is on the front side of the elongate body during introduction into the orifice (15), of the human or animal body and a proximal end (4) on the opposite side, wherein the elongate body is a hollow body comprising a reception chamber (8) in its interior, which reception chamber (8) is arranged for reception of a human finger (9), characterized in that one or more guiding elements (5, 21) for guiding a medical examination and/or intervention component (6) are located on or in the elongate body and at least one image gathering device (7), which is arranged for gathering of images in front of the distal end (3) of the elongate body (2), is arranged on or in the elongate body (2).

Abstract: System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy. Further, the invention enables the incorporation of both sensing and therapeutic devices on the same substrate allowing for faster treatment of diseased tissue and fewer devices to perform the same procedure.

Abstract: An insertion device is proposed for at least partly inserting a subcutaneous device, more particularly a subcutaneous sensor for detecting at least one analyte, into body tissue. The insertion device has at least one insertion aid and at least one subcutaneous device. The insertion aid has at least one substantially rigidly designed base body, more particularly an insertion needle, for insertion into the body tissue. The insertion device is designed to generate an adjustable holding force between the base body and the subcutaneous device. The insertion device is designed to set the holding force during the insertion such that the subcutaneous device is held against the base body. The insertion device is furthermore designed to set the holding force after the insertion such that the subcutaneous device is detachable from the base body.

Abstract: The sensor inserting device includes a device body, a movement mechanism which inserts a detector and an insertion needle into a body of a patient by moving a sensor with the insertion needle, and a dwelling member which is arranged on a moving path of the sensor and attached to the sensor by movement of the sensor caused by the movement mechanism. The dwelling member is allowed to dwell on the skin of the patient with the sensor and the transmitter connected at a location in which the detector is inserted into the body of the patient.

Abstract: An exercise information detecting apparatus of the present invention includes a heartbeat sensor which detects heartbeat data of a human body including a waveform signal, an exercise status detecting section which detects exercise data regarding an exercise status of the human body, an exercise status judging section which judges a change of the exercise status of the human body based on the exercise data detected by the exercise status detecting section, and a heart rate calculating section which removes, as a noise component, an invalid peak from among a plurality of peaks included in the waveform signal of the heartbeat data based on the change of the exercise status of the human body judged by the exercise status judging section.

Abstract: Systems and methods for detecting a present, or predicting a future, target physiologic event such as worsening heart failure (HF) are described. A system can comprise a patient information receiver circuit, at least two categorical risk analyzer circuits, and a categorical fusion circuit. The patient information receiver circuit receives physiologic signals and generates signal trends. The categorical risk analyzer circuit receives a category-specific input selected from the signal trends according to an associative physiologic condition indicative or correlative of the target event. The categorical risk analyzer circuit produces a signal trend metric indicating relative change in signal strength over time. The categorical risk analyzer circuit calculates a categorical risk index that indicates likelihood of the patient developing or presenting the associative physiologic condition.

Abstract: A biological information monitoring system includes: a measuring circuitry configured acquire information on a potential difference between two first electrodes that is placed on a first thorax of a user, wherein the first thorax is in a symmetric position to a second thorax that is positioned at the same side as a heart of the user; a detection circuitry configured to detect a plurality of S wave peaks based on the information on the potential difference to generate time-series information on the plurality of S wave peaks; and a processing circuitry configured to determine respiratory information on the user based on the time-series information on the plurality of S wave peaks, and to output the respiratory information as biological information.

Abstract: A method for controlling scanning preparation includes: obtaining a first scanning protocol of a current CT examination, controlling a CT scanner to perform a scanning preparation for a first scanning series according to the first scanning protocol; in case that there are one or more subsequent scanning series, controlling CT scanner to perform scanning preparations for the subsequent scanning series according to the first scanning protocol, where for each subsequent scanning series, the scanning preparation is performed during time interval between end of exposure of scanning series previous to the subsequent scanning series and starting of the subsequent scanning series; and obtaining a second scanning protocol of next CT examination and controlling the CT scanner to perform a scanning preparation for a first scanning series according to the second scanning protocol.

Abstract: A collimation system for a medical apparatus includes a collimation component having a laser emitting device, at least one photographing device, and a computing device. The laser emitting device is configured to the emit a laser beam to irradiate on a landmark on a body surface of a patient, the at least one photographing device is configured to take a photograph of a laser irradiation spot, and the computing device is configured to obtain a position of the laser irradiation spot by performing computation on images obtained by the at least one photographing device. The system further includes a moving component provided on the medical apparatus and configured to move to a target position for performing diagnosis or treatment. The medical apparatus automatically is configured to locate the moving component based on the position of the irradiation spot obtained from the computation.

Abstract: A photon-counting X-ray CT apparatus in an embodiment includes an X-ray tube, an X-ray detector, correction circuitry, and processing circuitry. The X-ray tube is configured to irradiate a subject with X-rays. The X-ray detector is configured to include an X-ray detection element that detects photons of the X-rays that the X-ray tube emits. The correction circuitry is configured to correct a count value observed by the X-ray detection element in each of a plurality of energy bins, based on at least one of the probability of escape in the X-ray detection element and the probability of crosstalk in the X-ray detection element. The processing circuitry is configured to generate a reconstruction image, based on the count values corrected by the correction circuitry.

Abstract: A method for generating an energy-resolved X-ray image is proposed, usable e.g. for mammography or CT applications. First, a preferably low-dose X-ray beam (5) is directed through a region of interest of an object (15) such as a female breast and initial X-ray intensity values are acquired. Based on these initial X-ray intensity values, energy threshold values of for example a photon-counting energy-resolving X-ray detector (9) are specifically adapted to local properties and features of the object (15). With such adapted energy threshold values, energy-resolved main X-ray intensity values are acquired for finally generating the energy-resolved X-ray image.

Abstract: Methods and apparatus for imaging with detectors having moving heads are provided. One apparatus includes a gantry and a plurality of detector units mounted to the gantry. At least some of the plurality of detector units are movable relative to the gantry to position one or more of the detector units with respect to a subject. The detector units are movable along parallel axes with respect to each other.

Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.

Abstract: This invention provides an X-ray CT image processing method that allows more flexible expression by expressing X-ray absorption coefficients probabilistically, makes it possible to acquire reconstructed images that are comparable to those obtained by conventional methods but involve lower X-ray doses, and can reduce beam-hardening artifacts. A probability distribution for the observation of projected X-rays is set and statistical inference is performed. Said probability distribution is expressed in terms of the process of observing a multiple-X-ray sum resulting from multiple projected X-rays being incident upon a detector. Bayesian inference in which the expected value of the posterior distribution is used for statistical inference is performed on the basis of a prior distribution for X-ray absorption coefficients, said prior distribution having parameters for the material and the observation process in terms of which the multiple-X-ray sum is expressed.

Abstract: A method and an apparatus for creating a correction map for electronic correction of digital projection data from which it is possible to reconstruct a tomosynthetic 3D X-ray image. Furthermore, a method and apparatus are described for electronic correction of digital projection data. In order to allow particularly simple correction of digital projection data, the creation of the correction map includes a reconstruction of the lowermost layer of the 3D X-ray image to be reconstructed from the digital projection data, which lowermost layer corresponds to the detector plane of the digital X-ray detector.

Abstract: A medical image display apparatus for displaying at least one medical image acquired from an object, the medical image display apparatus comprises: memory circuitry configured to store at least one functional image representing functional information of a tissue in the object, and at least one morphological image representing morphological information of the object; processing circuitry configured: to specify a region of interest based on the functional image; and to find a position of a characteristic structure of a human body by analyzing the morphological image, the position detection section being further configured to find area information corresponding to the position of the region of interest of the functional image; and a display configured to display the area information.

Abstract: An apparatus and method for computed tomography (CT) imaging to obtain an image from gated projection data, such as electrocardiographic gated projection data used in cardiac CT. The image reconstruction is performed using an iterative reconstruction method to minimize a cost function including a data-fidelity term (e.g., a system-matrix term) and a regularization term. The system-matrix term includes a weighted inner-product of the system-matrix equation, wherein the weighting matrix includes weighting values to correct the unequal data redundancy of the gated projection data.

Abstract: A method, a device, a system and a computer program are for controlling limited-area computer tomography imaging. The method includes determining location data of a first imaging object when the first imaging object is positioned in an imaging area, determining reference location data related to the first imaging object and adjusting the imaging area based on the location data of the first imaging object and said reference location data for imaging a second imaging object. The first and the second imaging object can be located at a distance determined by the reference location data from each other or symmetrically in relation to the reference location data.

Abstract: The radiographic imaging device that configures the disclosed radiographic imaging system has at least a camera that images a main cassette body. Said camera is integrally configured to a radiation source and a control device that controls the main cassette body or is integrally configured to a main radiation source body that houses the radiation source.

Abstract: An evaluation aid serves as a phantom (imitation lesion) when a digital X-ray image is taken, and evaluation is then carried out through the digital X-ray image. The evaluation aid can simplify evaluating image qualities of a digital X-ray image for X-ray absorption parts having different X-ray absorption ratios all at once. The evaluation aid contains a substrate (plate-like body) including a plurality of regions having different X-ray absorption ratios for taking a digital X-ray image to carry out evaluation. Step members are provided on the plate-like body so as to correspond to the plurality of regions, respectively, where each step member includes a plurality of subregions having different X-ray absorption ratios. Preferably the thicknesses and/or constituent materials of the plurality of regions of the substrate are different from each other in order to have different X-ray absorption ratios in these regions.

Abstract: Apparatus and methods for measuring and analyzing blood flow in vessels in the bodies of living subjects are provided. The true velocity vector, or a projection thereof onto a scan plane, for blood flowing at a location in a vessel is determined from multiple Doppler velocity components. The true velocity vector is displayed as a directional marker on an image comprising the vessel. The true velocity magnitude and angle, and scalar blood flow characteristics derived therefrom, are plotted as a functions of time and/or position across the depiction of the blood vessel in the image. Time intervals for which blood flow characteristic data is displayed and/or determined may be user configurable.

Abstract: Apparatus for locating bubbles in a subject comprises a plurality of pressure wave detectors arranged to operate as passive detectors to generate output signals in response to the receipt of pressure waves generated at a source comprising at least one bubble, and processing means arranged to receive signals from the detectors and to determine from the signals the position of the source.

Abstract: An ultrasonic observation apparatus includes: ultrasound probes; a storage unit that stores, for each ultrasound probe, attenuation that is a difference in signal intensity for each frequency between a predetermined common waveform and a waveform obtained by providing the ultrasound probes with a common transmission drive wave; a transmission drive wave generating unit that generates, for each ultrasound probe, a transmission drive wave obtained by adding the attenuation to the common transmission drive wave; and a reception signal correcting unit that performs a correction for each frequency, by adding the attenuation to a reception signal which is obtained by transmitting to the specimen the transmission echo having the predetermined common waveform and by converting the reception echo reflected from the specimen, the transmission echo being obtained by converting the transmission drive wave that is given by adding the attenuation to the common transmission drive wave.

Abstract: Disclosed herein is an ultrasonic diagnostic apparatus which includes a probe including a transducer installed to be rotatable, a driving device configured to rotate the transducer, at least one wire configured to transmit power of the driving device to the transducer, a handle case configured to accommodate the driving device therein, a cap coupled to the handle case to accommodate the transducer therein, and filled with oil, and a diaphragm formed of a deformable material and disposed between the cap and the handle case, wherein the wire is installed to pass through the diaphragm, and fixed to the diaphragm so that the diaphragm is deformed according to movement of the wire. Since the wire is fixedly installed to pass through the diaphragm and deformed according movement of the wire, oil in the cap is prevented from leaking to the handle case.

Abstract: An ultrasound observation apparatus that generates an ultrasound image based on an ultrasound signal obtained by receiving ultrasound reflected by a contrast medium in a target region of a subject to which the contrast medium is administered includes a measuring section configured to measure predetermined measurement items related to administration of the contrast medium, an image quality setting changing section configured to change an image quality setting of the ultrasound image from one to another of a first image quality setting suitable for observing how the contrast medium flows into the target region and a second image quality setting suitable for observing how the contrast medium is retained in the target region, and a control section configured to control setting changing operation by the image quality setting changing section based on a measurement result of the measuring section.

Abstract: An ultrasound observation apparatus for generating an ultrasound image based on an ultrasound signal obtained by an ultrasound probe having an ultrasound transducer for transmitting an ultrasound wave to an observation target and receiving the ultrasound wave reflected from the observation target. The ultrasound observation apparatus includes: a frequency analysis unit that analyzes a frequency of the ultrasound signal to calculate frequency spectra depending on a reception depth and a reception direction of the ultrasound signal; a frequency band setting unit that sets a frequency band used for calculating a feature of each of the frequency spectra by use of parameters associated with a frequency spectrum in each of candidate bands having different bandwidths; a feature calculation unit that calculates the feature of each of the frequency spectra based on the frequency band; and a feature image data generation unit that generates feature image data based on the feature.

Abstract: In accordance with the present invention, there is provided a liquid sample collection system, which generally comprises a means for grasping or a handle 12(b) a collection container or cup. The handle is an intervally formed unitary member having a first end or section, a medial section, angularly inclined with respect to the first section and a third section extending from the second section and substantially parallel to the first section.

Abstract: A microbiopsy device for taking biological samples, comprising a body including two or more cutting elements for cutting tissue to form a biological sample; and a chamber inside the body for receiving and retaining the biological sample, the chamber having an opening between the cutting elements, wherein the cutting elements are arranged to cut a section of tissue having a width of less than 1 mm.

Abstract: Collection devices, kits and methods related to sample collection and analysis can be used to collect and store samples (e.g., biological samples) from a variety of sources and optionally, for analysis of such samples (e.g., forensics analysis, medical diagnostics, etc.). Methods of production and use thereof are described herein. A device for collecting a sample (e.g., a sample including nucleic acid) includes an outer protective housing and a collection tip operably coupled to a carrier. The collection tip includes a hydrophilic and at least partially soluble material (e.g., hydrophilic and at least partially soluble polycaprolactone (PCL)) and is movable (e.g., retractable) from a first protected position within the outer protective housing to a second collecting position outside the outer protective housing.

Abstract: A method of expanding a narrowed region inside a living body involves positioning a liquid introducer in the narrowed region in the living body and introducing liquid into the narrowed region by way of the liquid introducer. The liquid applies an outwardly directed force on the narrowed region to expand the narrowed region. The narrowed region includes the renal pelvis, the entrance to the lower calix, the ureter, etc.

Abstract: A hydrogel composition is formed by conveying separate first and second liquid components subject to a selectively applied application pressure P(A) into an outlet path for mixing and discharge. A liquid flushing agent is automatically conveyed into the outlet path subject to a substantially constantly applied purge pressure P(P) when the application of P(A) is interrupted, to continuously flush residual hydrogel composition from the outlet path.