Abstract: Generally, embodiments of the invention relate to self-powered analyte determining devices (e.g., electrochemical analyte monitoring systems) that include a working electrode, a counter electrode, and an optional resistance value, where the working electrode includes analyte sensing components and the self-powered analyte determining device spontaneously passes a current directly proportional to analyte concentration in the absence of an external power source. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The biointerface layer increases sensor longevity and decrease sensor inaccuracy by inhibiting accumulation of cells, proteins, and other biological species on the outermost layers of the sensor.

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

Abstract: Methods and systems for providing continuous analyte monitoring including in vivo sensors that do not require any user calibration during in vivo use are provided. Also provided are methods and devices including continuous analyte monitoring systems that include in vivo sensors which do not require any system executed calibration or which do not require any factory based calibration, and which exhibit stable sensor sensitivity characteristics. Methods of manufacturing the no calibration sensors and post manufacturing packaging and storage techniques are also provided.

Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: Systems for applying a transcutaneous monitor to a person can include a telescoping assembly, a sensor, and a base with adhesive to couple the sensor to skin. The sensor can be located within the telescoping assembly while the base protrudes from a distal end of the system. The system can be configured to couple the sensor to the base by compressing the telescoping assembly.

Abstract: The present invention relates to methods and devices for extraction of bodily fluids from tissue by creating microscopic openings in the outermost layers of the skin and drawing out the fluid. One embodiment of the invention is a cylindrical hollow member, made of electrically conducting material, with sharpened edges.

Abstract: This invention relates to the means for detection of molecular and chemical matter utilizing multiple techniques covering electronics, optics, and imaging techniques. More particularly, this invention is related to detecting levels of certain molecules inside the body through non-invasive contact or non-contact with the body. More specifically, this invention is related to the means to detect levels of molecules associated with metabolic diseases, more particularly the early diagnosis of the disease, especially diabetes. This invention also relates to a medical device that utilizes electromagnetic waves of varying wavelengths and detects waves returned to the device.

Abstract: The present invention relates to a measurement error correction device of a bio-measurer and, more specifically, provides a measurement correction device which: enables a device for measuring a measurement error to be arranged inside a bio-measurer such that a measurement error can be corrected after the bio-measurer is manufactured; and enables a user to directly confirm, automatically or by the user's selection, whether the bio-measurer is normally operated at an early stage of the operation of the bio-measurer, thereby reducing the time and the cost for correcting a measurement error during a manufacturing process of the bio-measurer.

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer can comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The sensing membrane can also comprise a diffusion-resistance layer, which can comprise a base polymer having a lowest Tg of greater than ?50 C.

Abstract: Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, a processor configured to receive the output signal from the at least one light detector based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area with a ratio factor, eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and then determine a blood glucose level associated with a sample present in the target area based on the calculated attenuance with the processor.

Abstract: A handheld device measures all vital signs and some hemodynamic parameters from the human body and transmits measured information wirelessly to a web-based system, where the information can be analyzed by a clinician to help diagnose a patient. The system utilizes our discovery that bio-impedance signals used to determine vital signs and hemodynamic parameters can be measured over a conduction pathway extending from the patient's wrist to a location on their thoracic cavity, e.g. their chest or navel. The device's form factor can include re-usable electrode materials to reduce costs. Measurements made by the handheld device, which use the belly button as a ‘fiducial’ marker, facilitate consistent, daily measurements, thereby reducing positioning errors that reduce accuracy of standard impedance measurements. In this and other ways, the handheld device provides an effective tool for characterizing patients with chronic diseases, such as heart failure, renal disease, and hypertension.

Abstract: A patient monitor has multiple sensors adapted to attach to tissue sites of a living subject. The sensors generate sensor signals that are responsive to at least two wavelengths of optical radiation after attenuation by pulsatile blood within the tissue sites.

Abstract: Light beams emitted from one or more light sources may be directed into an abdomen of a pregnant mammal toward a fetus contained therein. Some of the light may be reflected by the pregnant woman and fetus and received at a detector over a first time. A photo detector into an electronic reflected signal, which may be communicated to a computer, may then convert the received light. The electronic reflected signal may then be processed and/or analyzed to isolate a portion of the electronic reflected signal reflected from the fetus. The isolated portion of the electronic reflected signal reflected from the fetus may then be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. An indication of the fetal hemoglobin oxygen saturation level may then be provided to an operator by way of, for example, a computer display.

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The biointerface layer increases sensor longevity and decrease sensor inaccuracy by inhibiting accumulation of cells, proteins, and other biological species on the outermost layers of the sensor.

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

Abstract: A medical needle comprising a flat puncturing part having front and back surfaces that are parallel to each other, wherein the puncturing part comprises a pair of side-surface inclined parts and provided at tips of respective side surfaces and a front-surface inclined part provided at a tip of the front surface, the pair of side-surface inclined parts and the front-surface inclined part each extend in an inclined manner relative to a puncturing direction so as to be tapered, and the tip of the front-surface inclined part adjoins a blade edge part formed by adjoining the tips of the pair of side-surface inclined parts and a depression is formed in the front surface of the puncturing part so as to partially indent the pair of side-surface inclined parts and the front-surface inclined part.

Abstract: The present invention relates to methods and devices for extraction of bodily fluids from tissue by creating microscopic openings in the outermost layers of the skin and drawing out the fluid. One embodiment of the invention is a cylindrical hollow member, made of electrically conducting material, with sharpened edges.

Abstract: An evaluation device that works out an objective evaluation value of a degree of concentration is provided. The evaluation device includes an acquirer, a storage, a processor and a corrector. The acquirer is configured to acquire a processing time measured for each of tasks performed by a user. The storage is configured to store the processing time for each of the tasks. The corrector is configured to, based on load factors that are set in accordance with respective degrees of difficulty of the tasks, correct and change the processing times stored in the storage to respective effective times corresponding to a prescribed degree of difficulty. The processor is configured to work out an evaluation value of user's degree of concentration based on a statistic acquired from a collection of the effective times.

Abstract: An emotion recognition device includes: a memory that stores a set of instructions; and at least one processor configured to execute the set of instructions to: classifies, based on a second emotion, a biological information pattern variation amount indicating a difference between first biological information and second biological information, the first biological information being measured by sensor from a test subject in a state in which a stimulus for inducing a first emotion is applied, the second biological information being measured in a state in which a stimulus for inducing the second emotion; and learn a relation between the biological information pattern variation amount and each of a plurality of emotions as the second emotion in a case where the biological information pattern variation amount is obtained, based on a result of classification of the biological information pattern variation amount.

Abstract: Apparatus, systems, and/or methods may provide a mental state determination. For example, a data collector may collect image data for a side of a face of a user from an image capture device on the user (e.g., a wearable device). The image data may include two or more perspectives of a feature on the side of the face of the user. In addition, a state determiner may determine a mental state of the user based on the image data. In one example, fields of view may be combined to determine a total region and/or a total overlap region. Changing the position that one or more image capture devices point may modulate the total region and/or the total overlap region. In addition, one or more sensors may be utilized to further improve mental data determinations.

Abstract: A reliable content evaluation method and system are disclosed. The system includes a brainwave detector, a bio signal detector, a first controller, and a second controller. The brainwave detector detects a brainwave signal of a subject provided with content and outputs a result. The bio signal detector detects bio signals of the subject and outputs a result. The first controller can modify the brainwave and the bio signals to a signal level available for the second controller. The second controller detects change of the brainwave signal and the bio signal through an analysis of the brain wave signal and the bio signal from the first controller. Then, the second controller determines at least one of a degree of engagement and an emotional reaction of the subject to the content, using changes in the brainwave signal and the bio signal, and evaluates the content using the determined results.

Abstract: Systems and methods for quantitative assessment of autism spectrum disorder based on detected responses of a subject to displayed animations are disclosed. In one example approach, a method for performing an autism assessment of a subject includes presenting as animation on a display, tracking the subject's eye gaze location on the display during specific scenes occurring within the animation where the specific scenes are associated with an autism construct, calculating an amount of time the subject's eye gaze tracks to predetermined regions on the display within the specific scenes to obtain a calculated eye gaze time associated with the specific scenes and the autism construct, and outputting an indication of the calculated eye gaze time. Animations may be selected to target a plurality of autism constructs and detected responses may be used to generate response mappings across the plurality of autism constructs.

Abstract: A portable work capacities testing apparatus comprising a portable computer, a hub releaseably interconnected with the portable computer, a dynamic strength and lifting device releaseably interconnected with the hub, a hand grip strength device releaseably interconnected with the hub, a finger pinch strength device releaseably interconnected with the hub, a forearm/wrist strength device releaseably interconnected with the hub, a handling/proprioception device releaseably interconnected with the hub, a finger flexion device releaseably interconnected with the hub, a whole body coordination device releaseably interconnected with the hub, and a strength push/pull/lift device releaseably interconnected with the hub.

Abstract: Methods and systems for assessing brain activity and collecting information related to a subject's condition and brain electrical activity are provided. The methods and systems include collecting and transferring data related to the neurological state of a subject. The systems and methods further include performing a first assessment of the collected data using an assessment device and performing a second assessment of the collected data using a computer. The methods further include comparing the first assessment and the second assessment and recording whether the first assessment and second assessment are consistent.

Abstract: Methods, systems, apparatus, and non-transitory computer readable media are disclosed utilizing brain-computer interfaces (BCIs). Various embodiments are disclosed to allow a user to directly select multiple-choice answers, to provide motorized wheelchair controls, and to allow a user to play a game via the BCI. When used in a cognitive assessment test, embodiments include the administration of unmodified standardized tests with results in the same or a similar format as those taken without a BCI. Various embodiments are disclosed to improve the accuracy of BCI test administration using a three-step process for each test question, which includes determining whether the user intends to select an answer, monitoring user brain activity to determine a selected answer, and verifying the selected answer. In addition, the selected answer may be verified by monitoring user brain activity in accordance with a hold-release process to determine whether a user intends to initiate a state change.

Abstract: A system is provided for monitoring patients with dysphagia, or swallowing impairments, that monitors muscle movement during intensive swallowing exercises to provide adjuvant visual feedback from surface electromyography.

Abstract: The invention provides a save and non-invasive alternative to the traditional modified Evans blue dye test for dysphagia in intubated patients. The method employs direct application of dye to the tongue, in combination with a tracheal tube that provides suction in the subglottal region above the cuff. By keeping the cuff inflated, the aspiration of food and liquid, as used in the traditional test, is avoided entirely.

Abstract: The present invention relates to a system device and method for monitoring infant oral motor kinetics (OMK), which can be used to assess the functional significance of the different sucking components, i.e., the plasticity of infant sucking skills in relation to their oral feeding performance, at a particular time, during the developmental period and/or during preventive or therapeutic intervention programs. It is a unique system and apparatus that provides a means to study the nonnutritive and/or nutritive sucking skills, i.e., the Suction and/or Expression components of sucking, of infants in the natural setting, i.e., during a normal feeding session.

Abstract: An artery visualization device for irradiating skin on the wrist back side with near-infrared light and forming near-infrared image of the wrist includes a placement table on which the wrist is placed, an irradiation unit including a light source emitting near-infrared light, imaging unit receiving light and forming wrist near-infrared image, the light incidents on the skin on the wrist back side and exiting from skin on the front, optical filter, and monitor. The artery visualization device includes a protrusion protruding from a placement table wrist placement surface. The protrusion compresses the back side skin on the wrist placed on the placement table from the back side, and irradiates the near-infrared light emitted from the light source to the skin on the back. The placement table includes a center placement portion and back of hand contact portion. The back of hand contact surface intersects obliquely with a wrist placement surface.

Abstract: A method and system for monitoring sleep of a subject is disclosed. In one aspect, the sleep of the subject is monitored using a sensor unit including infrared array sensors for sleep tracking, which is used to track motion and also to detect presence of the subject. Further, the environment surrounding the subject is monitored. Subsequently, sleep data and environment data is generated and stored on a memory of the sensor unit. The present disclosure makes recommendations to the carer to improve the sleep quality of the child based upon the sleep data and environmental data via a portable interaction device such as a mobile phone.

Abstract: A sleep monitor system includes a sensor unit, a processing unit and a mobile interface. The sensor unit is arranged to detect a number of variables corresponding to sleep status of a subject. The processing unit is programmed to receive data derived from the number of variables and process the data to produce user output. The mobile interface is arranged to present user output to one or more users.

Abstract: A method and apparatus for the treatment of Sleep Apnea events and Hypopnea episodes wherein one embodiment comprises a wearable, belt like apparatus containing a microphone and a plethysmograph. The microphone and plethysmograph generate signals that are representative of physiological aspects of respiration, and the signals are transferred to an imbedded computer. The embedded computer extracts the sound of breathing and the sound of the heart beat by Digital Signal Processing techniques. The embedded computer has elements for determining when respiration parameters falls out of defined boundaries for said respiration parameters. This exemplary method provides real-time detection of the onset of a Sleep Apnea event or Hypopnea episode and supplies stimulation signals upon the determination of a Sleep Apnea event or Hypopnea episode to initiate an inhalation. In one embodiment, the stimulus is applied to the patient by a cutaneous rumble effects actuator and/or audio effects broadcasting.

Abstract: The invention relates to a device (1) for non-invasively monitoring a sedated or anesthetized person (10) comprising a pain-stimulus-generating device (7), a measuring device (2) for capturing a saliva amylase value (S(t)) of the person (10), a control device (4), and an output device (5), wherein the control device (4) is designed in such a way that the control device controls the pain-stimulus-generating device (7) in order to produce a thermal pain stimulus (R), and that, alter the pain stimulus (R) has been produced, the control device (4) captures the saliva amylase value (S(t)) and outputs an output value (A) by means of the output device (5), wherein the output value (A) is the saliva amylase value (S(t)) or a value dependent on the saliva amylase value (S(t)).

Abstract: System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a nerve bundle, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy.

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

Abstract: The invention described herein is a system that features a Floormat and Handheld Sensor that operate in concert with a user's mobile device. The Floormat resembles a conventional bathroom scale, but features an enhanced set of measurements that include pulse rate and/or heart rate, SpO2, respiratory rate, weight, body composition, and Fluids. The Handheld Sensor features an integrated form factor that fits in a user's hand, which measures parameters such as blood pressure (e.g. systolic, diastolic, mean and pulse pressures), stroke volume, and cardiac output. Measurements of stroke volume and cardiac output require information from the Floormat (e.g., weight and body composition) to be sent to and processed by the Handheld Sensor. The Handheld Sensor can also make redundant measurements of heart rate, SpO2, and respiratory rate. Both systems transmit information through a wireless interface to a web-based system, where a clinician can analyze it to help diagnose a user.

Abstract: The embodiments disclose a new type of multi-function smart wristlets, in which a variety of electronic, optoelectronic, and thermal sensors are embedded. These sensors will collect data through various signals from both a person and the environment in order to perform many functions to help people improve their health; it also tells people of the environmental conditions in order for them to make the right decision about their outdoor activities. Also, this wristlet can be a sensor-key to open cars, house doors, garage doors, and so on. It also works as music player to play music in wireless headphones through Bluetooth function on the wristlet. In addition, at night it can also measure your steady heartbeat and blood flow rate along with breathing conditions through the detector sensors. This can monitor a person's health and sleeping quality. This function can also help to alert other family members through an app downloaded on family's phone if a condition appears in sleep or heart rate becomes irregular.

Abstract: A portable medical device adapted to be carried by a user, comprising at least one electrically actuated means for performing a therapeutic and/or a diagnostic function on a patient, at least one mobile electric power supply, a control unit having at least one microelectronic controller, at least one electronic memory and at least one multi-channel impact sensor unit. The impact sensor unit is adapted to simultaneously detect linear acceleration along the three space axes and angular rates around the three space axes. The impact sensor unit generates impact sensor data sets, which are electronically transferred to the microelectronic controller via an interface. The device further comprises a housing, in which the electric components of the device are contained.

Abstract: This invention comprises EEG glasses (electroencephalographic eyewear) with a side section of an eyewear frame which spans forward and upward onto a portion of the person's forehead and then curves back downward to connect to the front section of the eyewear frame. These EEG glasses (electroencephalographic eyewear) further include a flexible protrusion which is attached to the side section and an electromagnetic energy sensor which collects data concerning electromagnetic brain activity, wherein the flexible protrusion holds the electromagnetic energy sensor.

Abstract: The invention provides a wearing method and a wearing apparatus. The wearing method includes disposing a contact component on an inner side of a fabric to contact a user's skin; disposing an information capturing device on the fabric, wherein the information capturing device couples to the contact component; detecting at least one sensing information by the contact component and the information capturing device; and generating a prompt signal according to the at least one sensing information.

Abstract: A device for acquiring and collecting physiological signals is disclosed. In at least one embodiment, the device provides an at least one sensor having a conductive layer comprising a conductive fabric of interlaced conductive and non-conductive fibers and a plurality of orifices throughout the conductive fabric, wherein the plurality of orifices are filled with a silicone rubber, and wherein the silicone rubber is attached to the conductive fabric without the use of an adhesive. An electrical connector is connected to the conductive layer, the electrical connector providing a separable interface between the conductive layer and an electronic instrument. The device further provides an electronic instrument for receiving and collecting signals acquired from the at least one sensor.

Abstract: Systems and methods for a self-contained shoe insole device to monitor biomechanics and motion are disclosed. The systems and methods allow monitoring for orthopedic diagnostics, fitness tracking, and social/gaming activities using a shoe insole device with multiple sensor locations for pressure, acceleration, rotation rate, all forms of inertial data in three axes, position/location, heart rate, and other physical attributes. The shoe insole device can include a plurality of layers, with one layer containing a plurality of sensors, and an electronics component for collecting, reading, storing and transmitting the sensor data. The shoe insole device can wirelessly connect with external computing devices for monitoring and feedback directly to the user or a health care or fitness training professional, or across multiple users in a social or gaming situation. The system can further be provided for monitoring and tracking physical activity and enable a variety of interactions based upon the collected data.

Abstract: A physiological monitoring system features a Floormat and Handheld Sensor connected by a cable. A user stands on the Floormat and grips the Handheld Sensor. These components measure time-dependent physiological waveforms from a user over a conduction pathway extending from the user's hand or wrist to their feet. The Handheld Sensor and Floormat use a combination of electrodes that inject current into the user's body and collect bioelectric signals that, with processing, yield ECG, impedance, and bioreactance waveforms. Simultaneously, the Handheld Sensor measures photoplethysmogram waveforms with red and infrared radiation and pressure waveforms from the user's fingers and wrist, while the Floormat measures signals from load cells to determine ‘force’ waveforms to determine the user's weight, and ballistocardiogram waveforms to determine parameters related to cardiac contractility.

Abstract: Provided are devices, systems and methods for measuring, evaluating and displaying medical parameters in a patient. Specifically disclosed is a medical device which comprises a collar which fits on a patients neck and displays two or more medical parameters. Also disclosed is an ultrasound probe and suction cup for monitoring a patient.

Abstract: An apparatus for measuring a bio-signal includes: a light source emitting a predetermined amount of light into a human body; a light receiving unit receiving at least some of the predetermined amount of light; and a cover, which is touchable by the human body, protecting the light source and the light receiving unit. The light source and the cover are arranged such that the light source and the cover are separated by a first gap, the light receiving unit and the cover are arranged such that the light receiving unit and the cover are separated by a second gap, and the first gap is less than the second gap.