Patents Issued in July 25, 2017
  • Patent number: 9714384
    Abstract: The invention relates to a layer or article comprising cholesteric liquid crystal polymer particles, which are optionally dispersed in a continuous phase, to cholesteric polymer particles for use in such a layer or article, to methods of preparing such a layer or article, and to the use of such a layer or article as optical element, in windows or electrooptical devices like liquid crystal displays (LCDs).
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: July 25, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Eduardo Beltran Gracia, Owain Llyr Parri
  • Patent number: 9714385
    Abstract: The present invention relates to a process for the conversion of a low molecular weight polymeric byproduct obtained during production of high density polyethylene (HDPE), commonly known as low polymer wax (LPW) or polymer mud, into different products like different grades of paraffin wax, microcrystalline wax, lube and grease base stocks by a process comprising of thermal treatment in an inert atmosphere in the presence of organic peroxides or hydroperoxides and metal oxides. The end product depends upon the suitable selection of various process parameters like type of peroxides or hydroperoxides, metal oxides, temperature and duration of reaction.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: July 25, 2017
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Hayat Ullah Khan, Manisha Sahai, Sanat Kumar, Ajay Kumar, Gananath Doulat Thakre, Savita Kaul, Shrikant Madhusudan Nanoti, Bal Mukand Shukla, Madhukar Onkarnath Garg, Paulose Anthony Thrissokaran, Ajit Kumar Chaturvedi
  • Patent number: 9714386
    Abstract: This disclosure relates to the production of xylenes from syngas, in which the syngas is converted to an aromatic product by reaction with an isosynthesis catalyst and an aromatization catalyst. The isosynthesis catalyst and aromatization catalyst may be different catalysts or combined into a single catalyst. The aromatic product is then subjected to one of more of (i) xylene isomerization, (ii) transalkylation with at least one C9+ aromatic hydrocarbon, and (iii) alkylation with methanol and/or carbon monoxide and hydrogen to increase its p-xylene content.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: July 25, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Paul F. Keusenkothen, Juan D. Henao
  • Patent number: 9714387
    Abstract: Catalysts and processes designed to convert DME and/or methanol and hydrogen (H2) to desirable liquid fuels are described. These catalysts produce the fuels efficiently and with a high selectivity and yield, and reduce the formation of aromatic hydrocarbons by incorporating H2 into the products. Also described are process methods to further upgrade these fuels to higher molecular weight liquid fuel mixtures, which have physical properties comparable with current commercially used liquid fuels.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: July 25, 2017
    Assignee: Alliance for Sustainable Energy, LLC
    Inventors: Jesse Hensley, Daniel A. Ruddy, Joshua A. Schaidle, Mayank Behl
  • Patent number: 9714388
    Abstract: A process includes continuous steps and batch steps for recycling waste oil, fuel or antifreeze. The continuous steps include determining the volume of waste; pumping waste toward a distillation vessel; mixing waste with heated waste, and while flowing the waste into the distillation vessel performing steps of: maintaining a vacuum; heating the waste; returning a first portion of heated waste to the distillation vessel and a second-portion to mix with the waste feed; sending gaseous vapors to a condenser; returning some condensed liquid to the distillation vessel; and delivering condensed liquid as a product. The batch steps include: stopping waste flow into the distillation vessel; reducing pressure; heating the waste; returning the heated waste to the distillation vessel; condensing gaseous vapors; returning some condensed effluent to the distillation vessel; delivering some condensed effluent as a first product; and delivering heated waste as a second product.
    Type: Grant
    Filed: June 19, 2016
    Date of Patent: July 25, 2017
    Inventor: Rohit D. Joshi
  • Patent number: 9714389
    Abstract: A method of treating a first batch of oil sludge containing entrapped oil residue comprises the steps comprises the steps of bringing into contact the first batch of oil sludge to a liquid composition of an emulsion with or without a carrier, wherein the emulsion comprises an alkylpolyglucoside surfactant in 2 to 40% by weight of total composition; a co-surfactant in 1 to 30% by weight of total composition selected from the group consisting of C3 to C18 alcohols, C3 to C18 alkyl lactates, lecithins, C3 to C18 fatty acids and any mixtures thereof; an oil phase in 15 to 90% by weight of total composition; and an aqueous phase in 0.5 to 20% by weight of total composition; homogenizing the liquid composition with the first batch of oil sludge; and fluidizing the oil sludge that the oil residues are substantially dissociated from the solid object forming a liquid phase including the liquid composition and the separated oil.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: July 25, 2017
    Assignee: BCI SABAH INTERNATIONAL PETROLEUM SDN. BHD.
    Inventors: Chun Hwa See, Wasan Saphanuchart, Ming Hoong Looi, Yang Loong Chong
  • Patent number: 9714390
    Abstract: A process for purifying a hydrocarbon feed, using a first adsorption unit with first and second adsorption columns respectively filled with first and second adsorbent solids by simultaneously: a) treating the liquid phase hydrocarbon feed in the first adsorption column by contact with the first adsorbent solid to adsorb at least a portion of impurities present and to produce hydrocarbon effluent which is depleted in impurities; b) treating a secondary liquid hydrocarbon feed constituted either by a fraction of the hydrocarbon feed or by a fraction of the hydrocarbon effluent and depleted in impurities to purify the secondary liquid hydrocarbon feed; c) heating the treated secondary liquid hydrocarbon feed from step b); d) regenerating the second adsorbent solid of the second adsorption column which comprises impurities with the secondary hydrocarbon feed heated in step c) to desorb the impurities to produce an effluent with impurities.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: July 25, 2017
    Assignee: AXENS
    Inventors: Isabelle Villechange, Tom Frising
  • Patent number: 9714391
    Abstract: A waste to fuel system is disclosed that provides for simplified pyrolysis and cracking of useful hydrocarbons from waste by using molten salt as a heat transfer medium in the pyrolysis stage and using molten salt mixed with catalyst in the cracking stage.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: July 25, 2017
    Inventor: Johnny D. Combs
  • Patent number: 9714392
    Abstract: Deep desulfurization of hydrocarbon feeds containing undesired organosulfur compounds to produce a hydrocarbon product having low levels of sulfur, i.e., 15 ppmw or less of sulfur, is achieved by first subjecting the entire feed to an extraction zone to separate an aromatic-rich fraction containing a substantial amount of the aromatic refractory and sterically hindered sulfur-containing compounds and an aromatic-lean fraction containing a substantial amount of the labile sulfur-containing compounds. The aromatic-rich fraction is contacted with isomerization catalyst, and the isomerized aromatic-rich fraction and the aromatic-lean fraction are combined and contacted with a hydrotreating catalyst in a hydrodesulfurization reaction zone operating under mild conditions to reduce the quantity of organosulfur compounds to an ultra-low level.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: July 25, 2017
    Assignee: Saudi Arabian Oil Company
    Inventor: Omer Refa Koseoglu
  • Patent number: 9714393
    Abstract: A compound useful for reducing fouling in a hydrocarbon refining process is provided. A method for preparing the compound includes functionalizing a polymer having a vinyl chain end to obtain a terminal group having one or more anhydride units, and reacting the anhydride units with a polyamine. Methods of using the compound and compositions thereof are also provided.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: July 25, 2017
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Man Kit Ng, Glen B. Brons, Matthew W. Holtcamp, Donna J. Crowther, Patrick Brant, Hong Cheng, Clarence Chase
  • Patent number: 9714394
    Abstract: A method for producing an ashless coal includes a slurry preparation, an extraction, a separation, an ashless coal acquirement, and a by-product acquirement. In the by-product acquirement, a solvent used in the slurry preparation is evaporated and separated from a solid-content concentrated liquid separated in the separation, and then, a by-product coal is acquired. The by-product coal is used as a fuel for heating a slurry obtained in the slurry preparation.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 25, 2017
    Assignee: Kobe Steel, Ltd.
    Inventors: Shigeru Kinoshita, Noriyuki Okuyama, Takuya Yoshida, Koji Sakai
  • Patent number: 9714395
    Abstract: A lubricating oil composition is provided by blending a base oil and an additive, the additive including (a) at least one of an alkaline earth metal sulfonate, an alkaline earth metal salicylate and an alkaline earth metal phenate, (b) a sulfur-containing phosphorus compound, and (c) a thiadiazole compound. A product ((c)×P) of a mass (mass %) of the component (c) and a mass (mass ppm) of a phosphorus element in the component (b) in the composition is in a range from 1 to 50.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 25, 2017
    Assignee: IDEMITSU KOSAN CO., LTD.
    Inventor: Toshiaki Iwai
  • Patent number: 9714396
    Abstract: A method of forming dual melamine/acrylic walled microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the use of select (meth)acrylate monomers and/or oligomers and/or select self-condensing melamine resins.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 25, 2017
    Assignee: ENCAPSYS LLC
    Inventors: Linsheng Feng, Robert Stanley Bobnock
  • Patent number: 9714397
    Abstract: A method of forming microcapsules having improved physical properties and release control as well as the microcapsules formed by the process wherein the capsule wall is formed by the concurrent polymerization of monomers, oligomer and/or prepolymers on the inside of the capsule wall and different monomers, oligomers and/or prepolymers on the exterior of the capsule wall as it forms.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: July 25, 2017
    Assignee: ENCAPSYS LLC
    Inventors: Linsheng Feng, Todd Arlin Schwantes, Robert Stanley Bobnock, Nianxi Yan
  • Patent number: 9714398
    Abstract: Methods are provided for recovering oil from a process stream mixture in a corn to ethanol process. The method comprises adding an oil separation aid to the process stream wherein the oil separation aid is an alkyl polyglycoside (APG).
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: July 25, 2017
    Assignee: General Electric Company
    Inventor: Umit Turunc
  • Patent number: 9714399
    Abstract: A process includes the transesterification of a fatty acid triglyceride ester with a salt of hydroxycarboxylic acid without making use of organic solvents. The process can carried out with natural oils as starting material and produces a mixture of medium chain mono and diglycerides and medium chain esters of hydroxycarboxylic acid.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: July 25, 2017
    Assignee: Purac Biochem BV
    Inventors: Bastiaan Jeroen Victor Verkuijl, Symone Kok
  • Patent number: 9714400
    Abstract: The present invention concerns the use of C16-alkyl betaine as a fabric softener, notably for fabric softening compositions. The invention also concerns a method of treating fabric which comprises the step of contacting said fabric in the rinse cycle of a fabric washing machine with an aqueous medium containing a composition as defined herein.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: July 25, 2017
    Assignee: Rhodia Operations
    Inventors: Lin He, Hai Zhou Zhang
  • Patent number: 9714401
    Abstract: A composition including a plurality of particles, wherein the particles include: about 30% to about 95% by weight of a carrier; about 0.1% to about 30% by weight of a perfume; and about 0.00025% to about 30% by weight of a malodor agent; wherein the malodor agent comprises one or more malodor reduction materials having a Blocker Index of less than 3 or a Blocker Index average of 3 to about 0.001; and wherein each of the particles has a mass between about 0.1 mg to about 5 g.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: July 25, 2017
    Assignee: The Procter & Gamble Company
    Inventor: Gayle Marie Frankenbach
  • Patent number: 9714402
    Abstract: The present invention relates to the use of bis-pyranonylmethanes in detergents and cleaning agents to improve the washing or cleaning performance in regard to bleachable stains.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: July 25, 2017
    Assignee: Henkel AG & Co. KGaA
    Inventors: Christian Kropf, Nicole Bode, Thomas Gerke, Christian Umbreit, Sylvia Aust
  • Patent number: 9714403
    Abstract: Compositions comprising cellulase and at least one poly alpha-1,3-glucan ether compound having a degree of substitution with a positively charged organic group of about 0.05-3.0 are disclosed. Such compositions can be dry or aqueous, the latter of which can have a viscosity of at least about 10 cPs. The disclosed composition can be in the form of a personal care product, household product, or industrial product, for example. Also disclosed are a method for preparing an aqueous composition comprising cellulase and a poly alpha-1,3-glucan ether compound, and a method of treating a material such as fabric by contacting it with this aqueous composition.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: July 25, 2017
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Kevin D Nagy, Ayrookaran Poulose, T Joseph Dennes, Perry G Caimi, Jayme L Paullin, Susan Marie Hennessey
  • Patent number: 9714404
    Abstract: Various embodiments provide a bioreactor for producing a bioproduct comprising one or more catalytically active zones located in a housing and adapted to keep two incompatible gaseous reactants separated when in a gas phase, wherein each of the one or more catalytically active zones may comprise a catalytic component retainer and a catalytic component retained within and/or thereon. Each of the catalytically active zones may additionally or alternatively comprise a liquid medium located on either side of the catalytic component retainer. Catalytic component may include a microbial cell culture located within and/or on the catalytic component retainer, a suspended catalytic component suspended in the liquid medium, or a combination thereof. Methods of using various embodiments of the bioreactor to produce a bioproduct, such as isobutanol, are also provided.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: July 25, 2017
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: Robert Mark Worden, Yangmu Chloe Liu
  • Patent number: 9714405
    Abstract: Bioprocessing container tube management systems, totes including the systems, and methods of using the systems, are disclosed.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: July 25, 2017
    Assignee: PALL CORPORATION
    Inventors: Michael B. Seal, Nicholas L. Yoward
  • Patent number: 9714406
    Abstract: Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a component thereof may then be stored or further processed, e.g., combined with a divalent alkaline earth metal cation, under conditions sufficient to produce a solid carbonate composition. Aspects of the invention further include systems for practicing the methods, as well as products produced by the methods.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: July 25, 2017
    Assignee: Blue Planet, Ltd.
    Inventors: Brent Richard Constantz, Mark Bewernitz, Jacob Schneider, Chris Camire
  • Patent number: 9714407
    Abstract: A device for applying an electromagnetic field to a biological feedstock sample is disclosed. The device includes a coaxial electrical structure including a center conductor and a ground conductor which surrounds the center conductor, a load including a resistor and the biological feedstock sample being positioned between one end of the center conductor and a conductive wall which extends the ground conductor into a plane substantially perpendicular to the axis of the center conductor, the resistor having a first end connected to the center conductor and a second end connected to the conductive wall, the resistor defining an internal volume wherein the biological feedstock sample is placed.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: July 25, 2017
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventors: Rene Vezinet, Mathieu Croizer, Jean-Christophe Diot, Alexandre Catrain
  • Patent number: 9714408
    Abstract: In a cell culture in a sealed cell culture container, gradual deterioration of culture environment is prevented.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: July 25, 2017
    Assignee: Toyo Seikan Group Holdings, LTD.
    Inventors: Satoshi Tanaka, Yoichi Ishizaki, Ryo Suenaga, Yoriko Tokita, Masahito Kogure
  • Patent number: 9714409
    Abstract: The invention may be broadly defined as the addition of Argon to FFPE procedures as an RNA stabilizing agent. Argon is an inert gas from the Noble gas group with low saturation concentrations in water. It is therefore highly surprising that Argon would have any effect on RNA stability in the presence of Formalin, or any other chemical. This property of Argon appears to be specific in that other inert gases fail to show any RNA stabilizing effect.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: July 25, 2017
    Assignees: American Air Liquide, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Vasuhi Rasanayagam, Sagar D. Joshi, Meenakshi Sundaram, Stephen M. Hewitt, Joon-Yong Chung
  • Patent number: 9714410
    Abstract: It is an object of the present invention to allow a cell to produce a protein at a high level using a medium containing an enzymatic degradation product of fish meat or a fish meat extract. A method of culturing a cell comprising starting culturing in an initial medium and feeding at least once a feed medium to the initial medium during culturing, wherein at least one of the initial medium or the feed medium contains an enzymatic degradation product of fish meat or a fish meat extract added thereto. A method of producing a protein of interest using the above culture method.
    Type: Grant
    Filed: December 26, 2005
    Date of Patent: July 25, 2017
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Susumu Goto, Shohei Kishishita, Shinya Takuma, Chikashi Hirashima
  • Patent number: 9714411
    Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: July 25, 2017
    Assignees: Baxalta GmbH, Baxalta Incorporated
    Inventors: Leopold Grillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
  • Patent number: 9714412
    Abstract: The present invention provides a method for freezing a stem cell or a cell derived therefrom, the method including the steps of providing a cell suspension, performing ice nucleation on the cell suspension, and lowering the temperature of the ice nucleated cell suspension to a temperature sufficiently low to allow long term storage of the stem cell. The method is preferably used for the cryopreservation of human embryonic stem cells.
    Type: Grant
    Filed: June 2, 2005
    Date of Patent: July 25, 2017
    Assignee: ES Cell International Pte Ltd.
    Inventors: Jeremy M Crook, Lucy Kravets
  • Patent number: 9714413
    Abstract: Disclosed is a method of producing non-exhausted immature dendritic cells (DCs) originating from at two different, allogeneic donors. In the method, a mixture of allogeneic leukocytes, which allogeneic leukocytes have been obtained from at least two different, allogeneic donors is provided. Subsequently, allogeneic monocytes are isolated from the mixture of allogeneic leukocytes. Thereafter, non-exhausted immature DCs are generated from said isolated allogeneic monocytes.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: July 25, 2017
    Assignee: IMMUNICUM AB
    Inventors: Alex Karlsson-Parra, Bengt Andersson
  • Patent number: 9714414
    Abstract: The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: July 25, 2017
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Rudolf Jaenisch, Yaqub Hanna, Marius Wernig, Christopher J. Lengner, Alexander Meissner, Oliver Tobias Brambrink, G. Grant Welstead, Ruth Foreman
  • Patent number: 9714415
    Abstract: A method for stem or progenitor cell culture. More precisely, the invention relates to a method for cell culture using one or more I?I (inter-alpha trypsin inhibitor or Inter-alpha inhibitor) protein(s) or part(s) thereof as a component in a cell culture media or a coating on a cell culture surface material. Furthermore the invention relates to a cell culture media and a cell culture coating/matrix provided with one or more I?I proteins(s) or part(s) thereof.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: July 25, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Sara Pijuan Galito, Christoffer Tamm, Cecilia Anneren
  • Patent number: 9714416
    Abstract: The present invention relates enzyme composition comprising a cellulolytic preparation and an acetylxylan esterase (AXE); and the used of cellulolytic enzyme compositions for hydrolyzing acetylated cellulosic material. Finally the invention also relates to processes of producing fermentation products from acetylated cellulosic materials using a cellulolytic enzyme composition of the invention.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: July 25, 2017
    Assignee: Novozymes A/S
    Inventors: Prashant Iyer, Armindo Ribiero Gaspar, James Croonenberghs, Thomas P. Binder
  • Patent number: 9714417
    Abstract: The present invention relates to isolated polypeptides having xylanase activity, catalytic domains, carbohydrate binding modules and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding modules. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding modules.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: July 25, 2017
    Assignee: Novozymes A/S
    Inventors: Brett McBrayer, Nikolaj Spodsberg
  • Patent number: 9714418
    Abstract: Provided are modified santalene synthase polypeptides, nucleic acid molecules encoding the modified santalene synthase polypeptides, and methods of using the modified santalene synthase polypeptides. The modified santalene synthase polypeptides include those that catalyze production of increased levels of terpenes or altered profiles thereof or both.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: July 25, 2017
    Assignee: Evolva, Inc.
    Inventors: Jean Davin Amick, Bryan N. Julien
  • Patent number: 9714419
    Abstract: The present invention provides PEGylated tyrosyl-tRNA synthetase (YRS) polypeptides, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The PEGylated YRS polypeptides of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic properties compared to non-PEGylated YRS polypeptides.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: July 25, 2017
    Assignee: aTyr Pharma, Inc.
    Inventors: Jeffrey D. Watkins, Ying Ji Buechler, Chi-Fang Wu, Minh-Ha Do, Alain P. Vasserot, John D. Mendlein
  • Patent number: 9714420
    Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: July 25, 2017
    Assignee: Accelerate Diagnostics, Inc.
    Inventors: Steven W. Metzger, Kenneth Robert Hance
  • Patent number: 9714421
    Abstract: Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: July 25, 2017
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Thazha P. Prakash, Punit P. Seth, Eric E. Swayze
  • Patent number: 9714422
    Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: July 25, 2017
    Assignee: UNIVERSITY OF SOUTHAMPTON
    Inventors: Igor Vorechovsky, Jana Kralovicova
  • Patent number: 9714423
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Paraoxonase 1 (PON1), in particular, by targeting material antisense polynucleotides of Paraoxonase 1 (PON1). The invention also relates to the identification of these antisense oligonucleoties and their use in treating diseases and disorders associated with the expression of PON1.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: July 25, 2017
    Assignee: cuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman
  • Patent number: 9714424
    Abstract: Reduction of ocular scarring is accomplished from the discovery that silencing of the expression of USP10 in the area of a wound under healing will reduce the accumulation of integrin on the cell's surface and activation of the fibrotic growth factor TGF?, thereby preventing ocular scarring.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 25, 2017
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Audrey Bernstein, Stephanie Gillespie
  • Patent number: 9714425
    Abstract: Disclosed are specific aphid dsRNA constructs that target either Chloride Intracellular Channel (CLIC) gene expression or Sucrase gene expression. Also disclosed is the use of dsRNA constructs of a CLIC gene to interfere with critical functions of CLIC gene peptide products. A novel method to develop nucleic acid control for pest management is also disclosed. Also disclosed is the use of dsRNA constructs to interfere with critical functions of Sucrase gene peptide products.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: July 25, 2017
    Assignee: The United States of America, as represented by The Secretary of Agriculture
    Inventors: Gary J. Puterka, Scott J. Nicholson
  • Patent number: 9714426
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium or BTP. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating viral diseases and disorders. The bacterium or BTP includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Grant
    Filed: March 14, 2015
    Date of Patent: July 25, 2017
    Assignee: Marina Biotech, Inc.
    Inventors: Johannes Fruehauf, Moreshwar B. Vaze, Floyd Stephen Laroux, Jr., Noel Joy Sauer
  • Patent number: 9714427
    Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: July 25, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
  • Patent number: 9714428
    Abstract: The present invention relates to methods and compositions for transforming soybean, corn, cotton, or canola explants using spectinomycin as a selective agent for transformation of the explants. The method may further comprise treatment of the explants with cytokinin during the transformation and regeneration process.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: July 25, 2017
    Assignee: Monsato Technology LLC
    Inventors: Brian J. Martinell, Michael W. Petersen, David A. Somers, Yuechun Wan, Edward Williams, Xudong Ye
  • Patent number: 9714429
    Abstract: This invention is in the field of plant biology and agriculture and relates to novel seed specific promoter regions. The present invention further provide methods of producing proteins and other products of interest and methods of controlling expression of nucleic acid sequences of interest using the seed specific promoter regions.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: July 25, 2017
    Assignee: ARKANSAS STATE UNIVERSITY
    Inventors: Elizabeth Hood, Thomas Teoh
  • Patent number: 9714430
    Abstract: Provided are isolated polypeptides comprising the amino acid sequence at least 80% homologous to SEQ ID NO:68, 51-66, 69-100, 379-656, 707-715, 720-723, 742-754, 764-771 or 772 with the proviso that the amino acid sequence is not as set forth by SEQ ID NO: 765 or 771, isolated polynucleotides comprising the nucleic acid sequence at least 80% identical to SEQ ID NOs:18, 1-16, 19-50, 101-378, 657-672, 674-706, 716-719, 724-741 and 755-763 with the proviso that the nucleic acid sequence is not as set forth by SEQ ID NO:756 or 762, and isolated polynucleotides selected from the group consisting of SEQ ID NOs:779-792 and methods of using same for increasing oil content, yield, growth rate, biomass, vigor, abiotic stress tolerance and/or nitrogen use efficiency of a plant.
    Type: Grant
    Filed: June 29, 2014
    Date of Patent: July 25, 2017
    Assignee: Evogene Ltd.
    Inventors: Eyal Emmanuel, Alex Diber, Evgenia Gold, Inbar Nevo, Basia Judith Vinocur, Sharon Ayal, Gil Ronen, Yoav Herschkovitz, Michael Gang, Dotan Dimet, Anat Idan
  • Patent number: 9714431
    Abstract: The present invention provides transgenic plants with altered oil content. The invention further provides nucleic acid sequences and methods for generating such plants.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: July 25, 2017
    Assignee: A.B. Seeds Ltd.
    Inventors: Rudy Maor, Einat Sitbon, Amir Avniel
  • Patent number: 9714432
    Abstract: The present invention provides use of a plant gene JAZ5a for improving drought-resistance of a plant. It further provides a method for improving the drought-resistance of a plant, comprising enhancing the expression or activity of Jaz5A in said plant.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: July 25, 2017
    Assignee: Keygene N.V.
    Inventor: Adrianus Johannes Van Tunen
  • Patent number: 9714433
    Abstract: Establishment of human pluripotent stem cells having properties close to human ES cells with the genome of the patient per se that can circumvent immunological rejection of transplanted cells from cells derived from a postnatal human tissue are described. Human pluripotent stem cells can be induced by introducing three genes of Oct3/4, Sox2 and Klf 4, or three genes of Oct3/4, Sox2 and Klf 4 plus the c-Myc gene or a histone deacetylase (HDAC) inhibitor of undifferentiated stem cells present in various human postnatal tissues in which each gene of Tert, Nanog, Oct3/4 and Sox2 has not undergone epigenetic inactivation.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: July 25, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Kazuhiro Sakurada, Tetsuya Ishikawa, Hideki Masaki, Shunichi Takahashi