Patents Issued in July 27, 2017
  • PHASE-CHANGE NANOPARTICLE
    Publication number: 20170209580
    Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.
    Type: Application
    Filed: April 4, 2017
    Publication date: July 27, 2017
    Applicant: NEW PHASE LTD.
    Inventors: Raphael HOF, Raz KHANDADASH, Ella FREMDER
  • Compositions with a Rheological Modifier to Reduce Dissolution Variability
    Publication number: 20170209581
    Abstract: The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.
    Type: Application
    Filed: January 4, 2017
    Publication date: July 27, 2017
    Inventors: Su Il Yum, Wendy Chao, Huey-Ching Su, Roger Fu, Michael S. Zamloot, Karl Bratin, Ravi M. Shanker
  • PROTEIN FORMULATIONS
    Publication number: 20170209582
    Abstract: The present disclosure provides solid protein formulations that are stable over a variety of temperatures for extended time periods. The present disclosure also provides methods of making and using these formulations.
    Type: Application
    Filed: June 15, 2015
    Publication date: July 27, 2017
    Applicant: AMGEN INC.
    Inventors: Sungae PARK, Arnold J. MCAULEY
  • COMPOSITIONS AND METHODS FOR DELIVERING AN AGENT TO A WOUND
    Publication number: 20170209583
    Abstract: The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
    Inventors: WARREN O. HAGGARD, SCOTT P. NOEL, JOEL D. BUMGARDNER
  • COMPOSITIONS FOR TARGETING MACROPHAGES AND OTHER CD206 HIGH EXPRESSING CELLS AND METHODS OF TREATING AND DIAGNOSIS
    Publication number: 20170209584
    Abstract: Provided are compounds and compositions for targeting macrophages and other CD206 high expressing cells.
    Type: Application
    Filed: July 17, 2015
    Publication date: July 27, 2017
    Inventors: Larry SCHLESINGER, Eric BACHELDER, Fred COPE
  • HIGH PENETRATION COMPOSITIONS AND USES THEREOF
    Publication number: 20170209585
    Abstract: The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents (NSAIAs), which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes.
    Type: Application
    Filed: January 10, 2017
    Publication date: July 27, 2017
    Inventors: Chongxi Yu, Lina XU
  • AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME
    Publication number: 20170209586
    Abstract: The presently described technology provides a novel class of prodrugs of quetiapine that can be synthesized by chemically conjugating amino acids, such as Lysine to quetiapine. The present technology also provides methods of treating patients, pharmaceutical compositions and methods of synthesizing conjugates of the present technology.
    Type: Application
    Filed: February 13, 2017
    Publication date: July 27, 2017
    Inventors: Travis Mickle, Sven Guenther, Sanjib Bera
  • FORMULATIONS OF INTRAARTICULAR PHARMACEUTICAL AGENTS AND METHODS FOR PREPARING AND USING THE SAME
    Publication number: 20170209587
    Abstract: Provided herein are compositions and methods for preparing intraarticular formulations comprising biocompatible pharmaceutical agents and use thereof in the treatment of diseases, such as degenerative bone diseases, including osteoarthritis of the knee, hip, or other joints, and similar chronic or acute destructive arthropathies resulting from autoimmune disorders or infectious disease.
    Type: Application
    Filed: July 20, 2015
    Publication date: July 27, 2017
    Inventors: Jeffrey J. TARRAND, Borje S. ANDERSSON
  • PEGYLATED INTERFERON-BETA VARIANT
    Publication number: 20170209588
    Abstract: The present invention provides a PEGylated IFN-? variant and a composition for preventing or treating hyperproliferative diseases, inflammatory diseases, autoimmune diseases or viral infectious diseases, the composition comprising the PEGylated IFN-? variant as an effective ingredient. The PEGylated IFN-? variant of the present invention has an excellent anti-viral efficacy, immune regulatory function and anti-cell growth efficacy by virtue of better pharmacokinetic properties compared to native IFN-? and non-PEGylated IFN-? variants, and therefore can be used usefully against various diseases. The present invention provides good patient convenience in terms of administration due to exhibition of an excellent pharmacological activity effect upon administration and a significant increase of half-life in blood over existing interferon formulations.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Inventors: Young-Kee SHIN, Young-Deug KIM, Kyoung SONG, Dong Hee NA, Seong Hoon JEONG, Dae Duk KIM, In Soo YOON, Hee Jung LEE, Sae Hyung LEE
  • NOVEL CONJUGATION REAGENTS
    Publication number: 20170209589
    Abstract: The invention provides compound of the general formula: in which each X independently represents a polymer chain; n represents an integer greater than 1; Q represents a linker; Y represents an amide group; and Z represents either —CH.(CH2L)2 or —C(CH2L)(?CH2), in which each L independently represents a leaving group. The compounds are useful reagents for the conjugation of polymers to proteins, the resulting conjugates being novel and also forming part of the invention.
    Type: Application
    Filed: April 7, 2017
    Publication date: July 27, 2017
    Inventors: Antony Robert GODWIN, Stephen James BROCCHINI
  • METHODS AND REAGENTS FOR EFFICIENT AND TARGETED DELIVERY OF THERAPEUTIC MOLECULES TO CXCR4 CELLS
    Publication number: 20170209590
    Abstract: Conjugates comprising a targeting moiety specific for the CXCR4 and based on the polyphemusin-derived peptide and a therapeutic or imaging agent are provided. Therapeutic and diagnostic methods with the conjugates which require specific targeting to CXCR4+ cells are provided as well.
    Type: Application
    Filed: January 10, 2017
    Publication date: July 27, 2017
    Inventors: Antonio Pedro VILLAVERDE CORRALES, Esther VAZQUEZ GOMEZ, Maria Virtudes CESPEDES NAVARRO, Isolda CASANOVA RIGAT, Neus FERRER MIRALLES, Ramon MANGUES BAFALLUY, Ugutz UNZUETA ELORZA
  • MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE
    Publication number: 20170209591
    Abstract: Provided herein are maytansinoid compounds, derivatives thereof, conjugates thereof, and methods of treating or preventing proliferative diseases with the same.
    Type: Application
    Filed: January 24, 2017
    Publication date: July 27, 2017
    Inventors: Thomas Nittoli, Thomas P. Markotan
  • Delivery Agents Targeted to Degraded Elastic Fibers
    Publication number: 20170209592
    Abstract: Methods and delivery agents for treatment of connective tissue that includes elastic fibers are described. Delivery agents are nano- or micro-sized particles that include a biologically active compound useful in treatment of degraded elastic fibers and an anchoring agent at a surface that binds at or near the area of degraded elastic fibers. The delivery agents may be utilized for targeted delivery of biologically active compounds to degraded elastic fibers so as to maintain and/or regenerate the elastin component of connective tissue, and prevent further degradation and/or rehabilitate the structural architecture of the connective tissue.
    Type: Application
    Filed: February 1, 2017
    Publication date: July 27, 2017
    Inventors: Naren Vyavahare, Aditi Sinha
  • METHODS OF CONJUGATING AN AGENT TO A THIOL MOIETY IN A PROTEIN THAT CONTAINS AT LEAST ONE SULFIDE BOND
    Publication number: 20170209593
    Abstract: The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
    Type: Application
    Filed: January 24, 2017
    Publication date: July 27, 2017
    Inventors: Jayme FRANKLIN, Xin Xin LIN, Jeffrey GORRELL, Timothy TULLY, Matthew HUTCHINSON, Charity Tucker BECHTEL
  • SYNERGISTIC EFFECT OF ANTI-TROP-2 ANTIBODY-DRUG CONJUGATE IN COMBINATION THERAPY FOR TRIPLE-NEGATIVE BREAST CANCER WHEN USED WITH MICROTUBULE INHIBITORS OR PARP INHIBITORS
    Publication number: 20170209594
    Abstract: The present invention relates to combination therapy with ADCs against a tumor-associated antigen, such as Trop-2, and drugs, such as microtubule inhibitors and/or PARP inhibitors. Where ADCs are used, they preferably incorporate SN-38 or another drug that induces DNA strand breaks. Preferably, the combination of ADC and PARPi or microtubule inhibitor exhibits synergistic effects against the cancer. The combination therapy can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Inventors: David M. Goldenberg, Thomas M. Cardillo
  • DISULFUR BRIDGE LINKERS FOR CONJUGATION OF A CELL-BINDING MOLECULE
    Publication number: 20170209595
    Abstract: The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 27, 2017
    Applicant: Suzhou M-Conj Biotech Co., Ltd.
    Inventor: Robert Yongxin ZHAO
  • Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same
    Publication number: 20170209596
    Abstract: The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-?-cyclodextrin or sulfobutylether-7-?-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.
    Type: Application
    Filed: August 31, 2016
    Publication date: July 27, 2017
    Inventors: Jae Hyun Kim, Su Kyung Lee, Won Kyu Choi, Jong Lae Lim, Soon Kil Ahn, Hee Jong Shin, Chung Il Hong
  • CAPPED AND UNCAPPED RNA MOLECULES AND BLOCK COPOLYMERS FOR INTRACELLULAR DELIVERY OF RNA
    Publication number: 20170209597
    Abstract: The present invention relates to the use of at least one tetra functional non-ionic amphiphilic block copolymer as a vehicle for capped or uncapped mRNA for intracellular delivery for gene therapy.
    Type: Application
    Filed: April 1, 2015
    Publication date: July 27, 2017
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Nantes, Centre National de la Recherche Scientifique
    Inventor: Bruno Pitard
  • RECOMBINANT ADENO-ASSOCIATED VIRUS DELIVERY OF ALPHA-SARCOGLYCAN POLYNUCLEOTIDES
    Publication number: 20170209598
    Abstract: The present invention relates to recombinant adeno-associated virus (rAAV) delivery of an alpha-sarcoglycan gene. The invention provides rAAV products and methods of using the rAAV in the treatment of limb girdle muscular dystrophies such as LGMD2D.
    Type: Application
    Filed: September 2, 2016
    Publication date: July 27, 2017
    Inventors: Jerry R. Mendell, Louis Chicoine, Louise Rodino-Klapac, Kelly Reed Clark, Thomas J. Preston
  • Functionalized DNA Dendrimers For Gene Delivery To Cells
    Publication number: 20170209599
    Abstract: Compositions are disclosed which comprise a DNA dendrimer having one or more DNA sequences linked thereto, the DNA sequences comprising DNA sequences encoding a polypeptide or regulatory RNA linked to DNA sequences that regulate expression of the DNA sequences encoding a polypeptide or regulatory RNA to produce an RNA coding for the polypeptide or to produce the regulatory RNA. Also disclosed are methods for treating diseases and conditions of cells by delivering the dendrimers to the cells, with subsequent expression of the encoded polypeptide or regulatory RNA.
    Type: Application
    Filed: March 9, 2017
    Publication date: July 27, 2017
    Inventors: Robert C. Getts, Janet Sawicki
  • LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND USE THEREOF
    Publication number: 20170209600
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicants: VIB VZW, Life Sciences Research Partners VZW, Universiteit Gent
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Biopolymer-Nanoparticle Composite Implant for Tumor Cell Tracking
    Publication number: 20170209601
    Abstract: A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound to the tumor cells that have migrated out of the region can be detected by various imaging modalities. The implant can be in the shape of a brachytherapy spacer or radiotherapy fiducial maker or can be a coating on a brachytherapy spacer or fiducial marker. A method of treating cancer is provided by implanting one or more brachytherapy spacers or fiducial markers including the matrix material and an anti-cancer therapeutic agent dispersed within the matrix material.
    Type: Application
    Filed: July 27, 2015
    Publication date: July 27, 2017
    Inventors: Rajiv KUMAR, Srinivas SRIDHAR, Wilfred NGWA, Robert CORMACK, Gerassimos MAKRIGIORGOS
  • METHOD AND COMPOSITIONS FOR ORALLY ADMINISTERED CONTRAST AGENTS FOR MR IMAGING
    Publication number: 20170209602
    Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.
    Type: Application
    Filed: May 11, 2015
    Publication date: July 27, 2017
    Applicants: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, H. Lee Moffitt Cancer Center and Research Institute
    Inventors: Eugene A. Mash, Parastou Foroutan, Navath Suryakiran, Robert J. Gillies, Gary V. Martinez, David L. Morse
  • COMPOSITIONS TARGETING RADIATION-INDUCED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20170209603
    Abstract: The present invention is directed towards the compositions of peptide constructs that bind to GRP78 and the methods of use thereof.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 27, 2017
    Inventor: Dennis E. Hallahan
  • METHOD FOR DETECTING SOLUBLE OLIGOMERIC AMYLOID BETA
    Publication number: 20170209604
    Abstract: A method for detecting soluble oligomeric amyloid ? in a subject using, e.g., PET is provided.
    Type: Application
    Filed: April 11, 2017
    Publication date: July 27, 2017
    Applicant: Northwestern University
    Inventors: Grant A. Krafft, William L. Klein, Brett A Chromy, Lei Chang, Mary P. Lambert, Kirsten L. Viola
  • CARBOHYDRATE FUNCTIONALIZED CATANIONIC SURFACTANT VESICLES FOR DRUG DELIVERY
    Publication number: 20170209605
    Abstract: Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 27, 2017
    Applicant: University of Maryland, College Park
    Inventors: Douglas S English, Philip R DeShong, Daniel C Stein, Sara Lioi, Ju-Hee Park, Emily J Danoff, Glen B Thomas
  • HYDROGELS FOR LOCALIZED RADIOTHERAPY
    Publication number: 20170209606
    Abstract: Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be conjugated to a high molecular weight molecule, which may be encapsulated in a microparticle, where the microparticle is then dispersed within a hydrogel. The radioactive hydrogel may prevent leakage of the radioisotope to provide radiotherapy to a surgical margin while minimizing damage to surrounding normal tissue.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 27, 2017
    Inventors: Abdel Kareem Azab, Pilar de la Puente, Feda Azab
  • UVC DECONTAMINATION AND DETOXIFICATION DEVICE
    Publication number: 20170209607
    Abstract: A device for decontamination and detoxification by emitting light flashes rich in UV radiation, particularly UVC. The device includes: a flash lamp; a reflector, preferably placed behind the flash lamp, so as to reflect the light emitted by the lamp towards an output window; and a UV detector for measuring the UV radiation emitted by the lamp.
    Type: Application
    Filed: July 22, 2015
    Publication date: July 27, 2017
    Applicant: HEALTHY PULSE
    Inventor: Georges SAFRAOUI
  • CYCLIC UREA COMPOUNDS AS GRANZYME B INHIBITORS
    Publication number: 20170209608
    Abstract: An ultraviolet (UV) disinfection unit for disinfecting catheter line connections is provided. The unit can be used to disinfect solution set and transfer set catheters used for peritoneal dialysis. The unit can comprise a concavely curved bottom surface. A tubing trough of the unit can allow for ambidextrous positioning.
    Type: Application
    Filed: September 17, 2015
    Publication date: July 27, 2017
    Applicant: viDA Therapeutics Inc.
    Inventor: Dale R. Cameron
  • SYSTEMS AND METHODS FOR CREATING AN OXIDATION REDUCTION POTENTIAL (ORP) IN WATER FOR PATHOGENIC CONTROL WITH THE WATER AND OZONE SOLUTIONS THEREOF BEING SUPPLIED TO ONE OR MORE WASH-DOWN STATIONS
    Publication number: 20170209609
    Abstract: Systems and methods for creating an oxidation reduction potential (ORP) in water for pathogenic control are described. The systems and methods generate an oxidation reduction potential that provides pathogenic control of the solution as well as pathogenic control of the surfaces with which the solution comes in immediate contact. The system supplies the solution to one or more wash-down stations.
    Type: Application
    Filed: March 1, 2017
    Publication date: July 27, 2017
    Inventor: DANIEL W. LYNN
  • DEVICES, SYSTEMS AND METHODS FOR TREATING MEDICAL DEVICES HAVING PASSAGEWAYS WITH OZONE GAS
    Publication number: 20170209610
    Abstract: The present disclosure is generally related to devices, methods and systems for cleaning, disinfecting and/or sterilizing a medical device, medical hoses and tubes and accessories thereof with ozone gas, in particular the disclosure relates to devices, methods and systems with multiple receptacles for providing closed-loop fluid pathways to distribute ozone gas to inner passageways and the outer compartments of medical devices. The devices in accordance with an embodiment of the disclosure have two or more receptacles for distributing ozone gas, a gas-tight compartment, an ozone operating system, and one or more connector units configured to fluidly migrate ozone in closed-loop treatment systems.
    Type: Application
    Filed: April 7, 2017
    Publication date: July 27, 2017
    Inventors: Timothy LEYVA, William E. OLTSZA
  • EXTRUDED WAX MELT AND METHOD OF PRODUCING SAME
    Publication number: 20170209611
    Abstract: A wax melt blank is produced with an extrusion process and intended to later be cut to length into individual wax melts. The wax melt blank includes at least about fifty percent by weight of wax, a fragrance, and up to about fifty percent by weight of a filler. The wax, the fragrance, and the filler are homogeneously dispersed within the wax melt blank.
    Type: Application
    Filed: January 26, 2016
    Publication date: July 27, 2017
    Applicant: S.C. JOHNSON & SON, INC.
    Inventors: Michael J. Banco, Michael J. Fischer
  • HEATED AIR FRESHENER
    Publication number: 20170209612
    Abstract: A volatile material dispenser that includes a housing, an electrical assembly that is received within the housing and includes a heater, and an adjustment assembly that is coupled to the housing and is configured to support a cartridge. The adjustment assembly is movable between a maximum output position, an intermediate output position, and an off position.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 27, 2017
    Applicant: S. C. JOHNSON & SON, INC.
    Inventors: Nathan R. Westphal, Kevin Harrity, Alex Mecker, Chris A. Koontz
  • VOLATILE DISPENSER FOR USE IN VOLATILE DISPENSING SYSTEMS
    Publication number: 20170209613
    Abstract: A volatile dispenser for use in a volatile dispensing system is provided. The volatile dispenser includes a blister with a surface having at least one flexible portion, a permeable membrane sealable to the surface and configured to form a sealed reservoir with the blister, and a volatile material contained within the sealed reservoir. Diffusion of the volatile material through the permeable membrane generates a pressure differential between the sealed reservoir and an ambient atmosphere to induce a movement of the at least one flexible portion to perform at least one function for the volatile dispensing system.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 27, 2017
    Applicant: S. C. JOHNSON & SON, INC.
    Inventor: NATHAN R. WESTPHAL
  • SCENTED ORIGAMI VEHICLE AND ROOM FRESHENERS
    Publication number: 20170209614
    Abstract: One or more flat substrate sheets are provided with folding lines and slits, tabs, and apertures. The sheet or sheets are folded in origami style to create a three-dimensional object. The substrate sheet or sheets include fragrant material so as to emit a pleasant fragrance.
    Type: Application
    Filed: January 27, 2016
    Publication date: July 27, 2017
    Inventor: Jaime Ramos
  • SYSTEM FOR THE IMMEDIATE RELEASE OF ACTIVE AGENTS
    Publication number: 20170209615
    Abstract: It relates to a nonwoven fabric membrane for topical use on the skin, which comprises polymeric nanofibres and an active agent in an amount from 25 to 80% by weight with respect to the total weight of the nonwoven fabric membrane, wherein the active agent is soluble in a suitable biocompatible solvent system, and wherein the membrane is capable of releasing the active agent immediately when the membrane is contacted with an appropriate amount of the suitable solvent biocompatible system in which the active agent is completely solubilised. It also relates to a process for the preparation of the nonwoven fabric membrane, to a cosmetic or sanitary product and a kit comprising them and to their therapeutic and cosmetic uses.
    Type: Application
    Filed: August 3, 2015
    Publication date: July 27, 2017
    Applicants: HOSPITAL SANT JOAN DE DEU, UNIVERSITAT POLITÉCNICA DE CATALUNYA
    Inventors: Jose Antonio TORNERO GARCIA, Angel MONTERO CARCABOSO, Francesc CANO CASAS, Joan BERTRAN I LLAVINA
  • ABSORBENT CORES WITH HIGH MOLECULAR WEIGHT SUPERABSORBENT IMMOBILIZER
    Publication number: 20170209616
    Abstract: An absorbent article comprising an absorbent core, the absorbent core comprising superabsorbent polymer material and a superabsorbent immobilizer comprising at least about 50% of one or more polymers having a peak molecular weight of at least about 10 kg/mol.
    Type: Application
    Filed: January 24, 2017
    Publication date: July 27, 2017
    Inventor: Robert Haines TURNER
  • Adhesive for Use with Bone and Bone-Like Structures
    Publication number: 20170209617
    Abstract: An adhesive composition for bonding to bone and bone-like structures includes a polymerizable, multifunctional acidic monomer having a concentration ranging from about 5% to about 45% by weight of the adhesive composition, one or more multifunctional monomers with one or more ethylenically unsaturated groups having a concentration ranging from about 20% to about 60% by weight of the adhesive composition, an organically modified calcium phosphate salt with one or more pendant polymerizable groups having a concentration ranging from about 1% to about 50% by weight of the adhesive composition, and a polymerization initiator system. A method of forming the adhesive composition is also provided.
    Type: Application
    Filed: January 26, 2016
    Publication date: July 27, 2017
    Inventors: Sunny Skaria, Kenneth Berk
  • COMPOSITE ePTFE AND SILICONE SOFT TISSUE IMPLANTS TO MINIMIZE CAPSULAR CONTRACTURE, WEIGHT, INFECTION AND PALPABILITY
    Publication number: 20170209618
    Abstract: Methods, systems, apparatuses and devices for implantation in a soft-tissue biological environment that include a primary layer for containing a filler substance, an interface and a secondary layer, including embodiments where the secondary layer an ePTFE layer, the primary layer is a silicone layer, the interface is mechanical or adhesive and the filler substance can include particulates and lattices.
    Type: Application
    Filed: January 9, 2017
    Publication date: July 27, 2017
    Inventor: Mark A. Anton
  • Methods for Localized Modification of Tissue Products
    Publication number: 20170209619
    Abstract: Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a cross-linking agent and/or a proteolytic enzyme to produce a tissue matrix with variable mechanical and/or biological properties.
    Type: Application
    Filed: January 30, 2017
    Publication date: July 27, 2017
    Inventors: Gary Monteiro, Christopher T. Wagner, Neil L. Rodriguez, Aubrey Irene Delossantos
  • IRREVERSIBLE ELECTROPORATION TO CREATE TISSUE SCAFFOLDS
    Publication number: 20170209620
    Abstract: The present invention provides engineered tissue scaffolds, engineered tissues, and methods of using them. The scaffolds and tissues are derived from natural tissues and are created using non-thermal irreversible electroporation (IRE). Use of IRE allows for ablation of cells of the tissue to be treated, but allows vascular and neural structures to remain essentially unharmed. Use of IRE thus permits preparation of thick tissue scaffolds and tissues due to the presence of vasculature within the scaffolds. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.
    Type: Application
    Filed: February 3, 2017
    Publication date: July 27, 2017
    Inventor: Rafael V. Davalos
  • USE OF CHORDIN-LIKE 1 OR COLLAGEN VI WITH MESENCHYMAL STEM CELLS
    Publication number: 20170209621
    Abstract: There are provided inter alia reagents for increasing growth, expansion or survival of mesenchymal stem cells in cell culture, and methods of use thereof.
    Type: Application
    Filed: January 20, 2017
    Publication date: July 27, 2017
    Inventors: Nidhi Bhutani, Piera Smeriglio, William J. Maloney, Sarah E. B. Taylor
  • GRAPHENE-BASED INK COMPOSITIONS FOR THREE-DIMENSIONAL PRINTING APPLICATIONS
    Publication number: 20170209622
    Abstract: Electrically conducting, biocompatible, biodegradable tissue growth comprising graphene flakes in a polymeric matrix are provided.
    Type: Application
    Filed: October 15, 2015
    Publication date: July 27, 2017
    Inventors: Ramille N. Shah, Adam E. Jakus, Mark C. Hersam, Ethan B. Secor
  • MATRIX FOR ENHANCED DELIVERY OF OSTEOINDUCTIVE MOLECULES IN BONE REPAIR
    Publication number: 20170209623
    Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
    Type: Application
    Filed: October 31, 2016
    Publication date: July 27, 2017
    Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
  • MULTI-COMPONENT NON-BIODEGRADABLE IMPLANT, A METHOD OF MAKING AND A METHOD OF IMPLANTATION
    Publication number: 20170209624
    Abstract: An implant comprising at least three components, namely, a solid hydrogel, a porous hydrogel adjacent to or surrounding the solid hydrogel (together considered “the hydrogel”), and a porous rigid base. The solid hydrogel and porous rigid base carry joint load, and the porous hydrogel layer and the porous rigid base allow for cellular migration into and around the implant. The invention is also a novel method of manufacturing the implant, a novel method of implanting the implant, and a method of treating, repairing or replacing biological tissue, more preferably musculoskeletal tissue, with the implant.
    Type: Application
    Filed: December 6, 2016
    Publication date: July 27, 2017
    Inventors: Suzanne A. Maher, Tony Chen, Joseph D. Lipman, Peter Torzilli, Russell Warren
  • ZWITTERIONIC HYDROGELS FOR DELIVERY OF BIOMOLECULES
    Publication number: 20170209625
    Abstract: The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual advance and enables a novel strategy for the utilization of zwitterionic motifs as therapeutics delivery vehicles and tissue engineering scaffolds.
    Type: Application
    Filed: July 6, 2015
    Publication date: July 27, 2017
    Inventors: Jie Song, Pingsheng Liu
  • METHOD FOR CREATING A PERSONALIZED GENE-ACTIVATED IMPLANT FOR REGENERATING BONE TISSUE
    Publication number: 20170209626
    Abstract: Provided is a method for construction of bone substitutes efficient in the repair of large bone defects. The method for constructing such medical products includes three-dimensional printing of a bioresorbable scaffold and its activation by gene constructions. Produced medicinal products may serve as an efficient alternative to bone autografts.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Applicant: "NEXTGEN" COMPANY LIMITED
    Inventors: Roman Vadimovich DEEV, Artur Aleksandrovich ISAEV, llya Yadigerovich BOZO, Vladimir Sergeevich KOMLEV, Alexey Yurevich DROBYSHEV
  • Medical Device With Enhanced Visibility
    Publication number: 20170209627
    Abstract: A medical device (1) with enhanced visibility for insertion into a human or animal body and/or for contact with human or animal tissue is provided, comprising a main body (10) and at least one first coating (11); said at least one first coating (11) at least partially covering the main body (10); and said at least one first coating (11) comprising an at least partially translucent matrix (111) and at least one luminescent component (112).
    Type: Application
    Filed: July 16, 2015
    Publication date: July 27, 2017
    Inventor: André Plass
  • Canister Lid and Corresponding Systems and Methods
    Publication number: 20170209628
    Abstract: A canister lid (100) for a canister (600) includes an annular perimeter (101) surrounding an interior portion (102). Rather than completely surrounding the interior portion, the annular perimeter is instead interrupted by a suction conduit (103) defined by a suction duct (104) separating a first lobe (105) and a second lobe (106). The suction duct (104) intersects the annular perimeter such that the first lobe is disposed interior of the annular perimeter while the second lobe is disposed exterior to the annular perimeter. The canister lid can further include one or more ports (110,111) extending from the interior portion.
    Type: Application
    Filed: January 25, 2016
    Publication date: July 27, 2017
    Inventors: Stuart Mintz, Derek Roberts, Brian Barkeley
  • Canister Lid and Corresponding Systems and Methods
    Publication number: 20170209629
    Abstract: A canister lid (100) for a canister (500) includes an annular perimeter (101) surrounding an interior portion (102). Rather than completely surrounding the interior portion, the annular perimeter is instead interrupted by a suction conduit (103) defined by a suction duct (104) separating a first lobe (105) and a second lobe (106). The suction duct (104) intersects the annular perimeter such that the first lobe is disposed interior of the annular perimeter while the second lobe is disposed exterior to the annular perimeter. The canister lid can further include one or more ports (110,111) extending from the interior portion.
    Type: Application
    Filed: February 20, 2017
    Publication date: July 27, 2017
    Inventors: Brian Barkeley, Derek Roberts, Zach Zott, Stuart Mintz