Patents Issued in August 1, 2017
-
Patent number: 9718727Abstract: Glasses with compressive stress profiles that allow higher surface compression and deeper depth of layer (DOL) than is allowable in glasses with stress profiles that follow the complementary error function at a given level of stored tension. In some instances, a buried layer or local maximum of increased compression, which can alter the direction of cracking systems, is present within the depth of layer. Theses compressive stress profiles are achieved by a three step process that includes a first ion exchange step to create compressive stress and depth of layer that follows the complimentary error function, a heat treatment at a temperature below the strain point of the glass to partially relax the stresses in the glass and diffuse larger alkali ions to a greater depth, and a re-ion-exchange at short times to re-establish high compressive stress at the surface.Type: GrantFiled: October 5, 2015Date of Patent: August 1, 2017Assignee: Corning IncorporatedInventors: Dana Craig Bookbinder, Richard Michael Fiacco, Timothy Michael Gross, Stephan Lvovich Logunov
-
Patent number: 9718728Abstract: In one aspect, a method for use in preparing a glass comprises: performing a first ion exchange process to replace at least a first ion in the glass with at least a second ion, the second ion being smaller than the first ion; and performing a second ion exchange process to replace at least the second ion in the glass with at least a third ion, the third ion being larger than the first ion. In another aspect, a glass is prepared at least in part by: performing a first ion exchange process to replace at least a first ion in the glass with at least a second ion, the second ion being smaller than the first ion; and performing a second ion exchange process to replace at least the second ion in the glass with at least a third ion, the third ion being larger than the first ion.Type: GrantFiled: January 20, 2016Date of Patent: August 1, 2017Assignee: International Business Machines CorporationInventors: Qiang Huang, Kenneth P. Rodbell, Asli Sahin
-
Patent number: 9718729Abstract: Biocides for bio-based binder compositions are disclosed. Bio-based binders include those having a nutrient source such as carbohydrate, protein or fat, which can serve as an energy source for organisms to grow in areas that contact binder. Principal areas that contact bio-based binder in a fiberglass insulation manufacturing process include the raw ingredients, the binder chemicals, the prepared binder dispersions, the forming hood and related equipment, the final insulation product and, importantly, the cleaning systems and washwater arising from cleaning the manufacturing equipment and/or forming the product. Frequently the washwater is stored until re-cycled for re-use. Storage may take place in tanks, towers, vats and even outdoor reservoirs, all of which may harbor the growth of unwanted organisms, for which a biocide is desirable.Type: GrantFiled: February 14, 2011Date of Patent: August 1, 2017Assignee: Owens Corning Intellectual Capital, LLCInventors: Jesus M. Hernandez-Torres, Liang Chen, William R. Cooper
-
Patent number: 9718730Abstract: A reinforcing fiber and reinforced material, which includes a fiber having a first radical wave therein, wherein said first radical wave includes an amplitude of between about 0.5 to 1 cm and a wave run width of about 0.05 to about 0.3 cm, and a leading run and trailing run of at least about 0.75.Type: GrantFiled: January 29, 2016Date of Patent: August 1, 2017Assignee: THE THOMAS MONAHAN CO.Inventors: Jon E. Monahan, Thomas F. Monahan
-
Patent number: 9718731Abstract: The present invention relates to a method for producing a binder comprising the following steps: a) providing a starting material, from raw materials, that has a molar (Ca+Mg)/(Si+Al+Fe) ratio from 1 to 3.5, a molar ratio Ca/Mg from 0.1 to 100, and a molar Al/Si ratio from 100 to 0.1, wherein constituents that are inert during the hydrothermal treatment in an autoclave are not taken into account for determination of the ratios, b) mixing the raw materials, c) hydrothermal treating of the starting material mixture produced in step b) in an autoclave at a temperature from 100 to 300° C. and a residence time from 0.1 to 24 h, wherein the water/solids ratio is 0.1 to 100, d) tempering the intermediate product obtained in step c) at 350 to 600° C., wherein the heating rate is 10-6000° C./min and the residence time is 0.01-600 min.Type: GrantFiled: May 7, 2014Date of Patent: August 1, 2017Assignee: HEIDELBERGCEMENT AGInventors: Frank Bullerjahn, Mohsen Ben Haha, Nicolas Spencer, Anca Itul, Dirk Schmitt
-
Patent number: 9718732Abstract: A cementitious composition including at least one cementitious material and at least one crack reducing admixture including: (i) from 0 to about 5 weight percent of at least one alcohol, based on the total weight of the admixture excluding water; and (ii) a compound having the chemical structure of formula (III): wherein: v is an integer from 0 to 50 and w is an integer from 0 to 50, with the proviso that the sum of v and w is at least 1 but not greater than 50. Also, methods of making the cementitious composition, reducing or eliminating the formation of cracks in a cementitious composition as the cementitious composition cures, and limiting the size of cracks which form in a cementitious composition as the cementitious composition cures using an admixture for cementitious compositions as described herein.Type: GrantFiled: November 21, 2014Date of Patent: August 1, 2017Assignee: Construction Research & Technology GmbHInventors: Steve Schaef, Emmanuel Attiogbe, Charles Kerobo, Stefan Muessig, Daniel Vojtko
-
Patent number: 9718733Abstract: An amphoteric betaine-type polycarboxylic acid water reducer and a preparation method therefor are provided in the present invention. An unsaturated betaine-type monomer A and an acrylic acid-type polyethylene glycol monomer B are placed in a reaction container, stirred until uniform and then an acrylic acid-type monomer C is added, the stirring is continued and water is added to make adjustments so as to make the total mass of the monomers account for 10%-20% of the total mass of the aqueous solution; and under the protection of an inert gas, the temperature is raised to 60° C.-100° C., an aqueous initiator solution is added, maintaining the temperature and reacting for 4-6 h, and after the reaction is completed, the solution is cooled to room temperature, and the pH value thereof is adjusted to 5-7 to prepare the amphoteric betaine-type polycarboxylic acid water reducer.Type: GrantFiled: March 8, 2016Date of Patent: August 1, 2017Assignee: SHENZHEN UNIVERSITYInventors: Shaojun Chen, Shiguo Chen, Zaochuan Ge, Chengbin Chen, Lidan Gu
-
Patent number: 9718734Abstract: Disclosed is a technique for suppressing a firing property and a dust generating property while improving bondability, in a thermal spray material for use in a thermite spraying process. The thermal spray material comprises a refractory material powder and a metal Si powder and capable of being sprayed onto a target surface using oxygen or oxygen-containing gas as a carrier gas and melt-adhered to the target surface based on heat generated by combustion of the metal Si powder, wherein the metal Si powder is contained in an amount of 10 to 25 mass % with respect to the entire thermal spray material, and wherein the metal Si powder has a median size of 10 ?m or less, and contains a fraction having a particle size of 2 ?m or less in an amount of 8 mass % or less with respect to the entire metal Si powder.Type: GrantFiled: November 7, 2014Date of Patent: August 1, 2017Assignee: KROSAKIHARIMA CORPORATIONInventors: Kazuhiro Honda, Taijirou Matsui
-
Patent number: 9718735Abstract: Components are disclosed which include a CMC substrate having a first surface and a second surface. The first surface is in fluid communication with a compressed, dry fluid, and the second surface is in fluid communication with a wet fluid stream and includes a hermetic coating. The components further include at least one opening extending from the first surface through a portion of the CMC substrate, wherein, upon removal of a fragment of one or both of the hermetic coating and the CMC substrate, the at least one opening selectively permits a flow of the compressed, dry fluid to the second surface. In one embodiment, the component is a gas turbine component, the wet fluid stream is a hot combustion stream, the hermetic coating is an environmental barrier coating, and the flow reduces or eliminates volatilization of the CMC substrate. Methods for forming the components are also disclosed.Type: GrantFiled: February 3, 2015Date of Patent: August 1, 2017Assignee: General Electric CompanyInventors: John McConnell Delvaux, Andres Jose Garcia-Crespo, Victor John Morgan, Jacob John Kittleson
-
Patent number: 9718736Abstract: Disclosed is a sintering process for ceramic sheets. After biscuit firing and glazing, a green body is placed in a kiln, wherein the temperature of the kiln is controlled such that: when the kiln temperature is 100-400° C., the temperature rise duration is 1-2 hours when the kiln temperature is 400-900° C., the temperature rise duration is 2-3 hours; when the kiln temperature is 900-1100° C., the temperature rise duration must reach 3 hours or more; when the kiln temperature is 1100-1350° C. the temperature rise duration is controlled to be 3-4 hours; and after the temperature reaches 1350° C., heat-preservation cooling is conducted; when the temperature drops to 1230-1270° C., the temperature is raised again to 1290-1310° C.; when the temperature drops again to 880-920° C., the kiln cover is opened for cooling, and the finished product is taken out.Type: GrantFiled: September 15, 2014Date of Patent: August 1, 2017Assignee: FUJIAN JIAMEI GROUP CORPORATIONInventor: Zhihan Chen
-
Patent number: 9718737Abstract: A coating composition includes water, a plurality of flakes having a maximum dimension less than 0.05 inches, a plurality of inorganic fibers, a thixotropic suspending agent that is insoluble in water, and a resin. Decorative coating on a concrete substrate is also provided.Type: GrantFiled: April 21, 2015Date of Patent: August 1, 2017Assignee: Behr Process CorporationInventor: Hector Antonio Perez
-
Patent number: 9718738Abstract: Fertilizer compositions are provided, where a fertilizer composition includes: an inner portion including a nitrogen containing material; and an outer portion covering the inner portion, the outer portion including a release agent (e.g. HTC, BR).Type: GrantFiled: February 20, 2015Date of Patent: August 1, 2017Assignee: ALCOA USA CORP.Inventors: David F. Iwig, Raymond J. Kilmer, Charles L. Dobbs, Judodine Nichols, John R. Smith, Mark L. Weaver, Shannon L. I. Parks, Mikhail Gershenzon
-
Patent number: 9718739Abstract: A pesticide, fungicidal, bactericidal, anti-pathogen or biocidal composition includes at least one biologically inert carrier; and at least one doped component including at least one fixed copper compound doped with at least one compound selected from the group consisting of iron compounds, zinc compounds, magnesium compounds, calcium compounds, and combinations and/or mixtures thereof. In one embodiment, the doped component has a particle size of about 0.5 nm to about 30 microns. A method for the control of pests includes the step of applying to the pests or their growth habitat the aforementioned composition. The method also includes the control of disease in citrus plants caused by vectors such as Psyllid nymphs, by applying the aforementioned composition to their growth habitat in citrus groves.Type: GrantFiled: March 31, 2015Date of Patent: August 1, 2017Inventor: Robert Sabin
-
Patent number: 9718740Abstract: A matrix assembly having a single detonating cord. Further, the matrix assembly has a first plurality of parallel portions of detonating cord arranged in a first plane and a second plurality of parallel portions of detonating cord arranged in a second plane, wherein each one of the second plurality of parallel portions intersects only one of the first plurality of parallel portions perpendicularly. Additionally, the matrix assembly has a plurality of open loops formed by the looping of the first plurality of parallel portions and the looping of the second plurality of parallel portions such that the open loops of the first plurality of parallel portions are geometrically symmetrical with the open loops of the second plurality of parallel portions. Further, the matrix assembly has two closed loops formed at opposing corners of the matrix assembly, the closed loops arranged geometrically symmetrical and formed from one of the first plurality of parallel portions and the second plurality of parallel portions.Type: GrantFiled: February 19, 2016Date of Patent: August 1, 2017Assignee: Matrix X, LLCInventor: Jon K. Mitchell
-
Patent number: 9718741Abstract: A process of converting a carbon-carbon multiple bond to a cyclopropane ring, comprising the addition of a N-alkyl-N-nitroso compound to a mixture of alkene precursor, aqueous base and Pd(II)-catalyst, with the N-alkyl-N-nitroso compound obtained directly from an alkyl amine derivative, NaNO2 and an acid via phase separation of the N-alkyl-N-nitroso compound from the aqueous phase.Type: GrantFiled: October 24, 2014Date of Patent: August 1, 2017Assignees: Givaudan, S.A., Amyris, Inc.Inventors: Fridtjof Schroeder, Fabian Ruethi
-
Patent number: 9718742Abstract: This specification discloses a process to convert a converted lignin feedstream to an aromatic composition comprised of aromatic compounds. The process follows the steps of exposing the converted lignin feedstream to at least one catalyst in the presence of donated hydrogen atoms at an exposure temperature greater than 190° C. for a time of at least thirty minutes. The donated hydrogen atoms are donated from at least one hydrogen donating compound during exposure of the converted lignin feedstream to the at least one catalyst at the exposure temperature. The resulting products are comprised largely of aromatics.Type: GrantFiled: August 27, 2013Date of Patent: August 1, 2017Assignee: Biochemtex S.p.A.Inventors: Krishna Sharma, Aaron Murray, Steven Ryba
-
Patent number: 9718743Abstract: A method for preparing a light olefin using an oxygen-containing compound, and a device for use thereof, more specifically, taking methanol and/or dimethyl ether as main starting materials, using a multi-stage (n?2) dense phase fluidized bed reactor and a multi-stage (m?2) catalyst regenerator, which solves the problem in the prior art of the uniformity of catalyst carbon deposition and the carbon content being difficult to control and the light olefin selectivity being low.Type: GrantFiled: December 3, 2013Date of Patent: August 1, 2017Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Zhongmin Liu, Mao Ye, Tao Zhang, Changqing He, Xiangao Wang, Yinfeng Zhao
-
Patent number: 9718744Abstract: Disclosed is a hydroalkylation process in which the hydroalkylation catalyst is activated in the presence of a flowing fluid comprising hydrogen and a condensable agent. The presence of the condensable agent enables fast, effective activation of the hydroalkylation catalyst precursor in a cost-effective manner. It also yields superior catalyst performance.Type: GrantFiled: September 26, 2014Date of Patent: August 1, 2017Assignee: ExxonMobil Chemical Patents Inc.Inventors: Gabor Kiss, Thomas E. Green, Keith H. Kuechler
-
Patent number: 9718745Abstract: The present disclosure provides a premixer for at least two gases, comprising: a tubular body having a closed end and an opposite, open end; a first flow passage for receiving a first gas, the first flow passage axially extending through the closed end into the tubular body in a sealable manner; a conical tube arranged in the tubular body, wherein a small end of the conical tube communicates with the first flow passage, and a large end of the conical tube extends toward the open end with an edge thereof being fixed to an inner wall of the tubular body, thereby defining a sealed distribution chamber between the tubular body and the conical tube; and a second flow passage arranged on a side portion of the tubular body for receiving a second gas, wherein the second flow passage communicates with the distribution chamber, so that the second gas can be introduced into said conical tube via the distribution chamber in a substantially radial manner.Type: GrantFiled: January 27, 2014Date of Patent: August 1, 2017Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY, SINOPECInventors: Weimin Yang, Wenjie Liu, Yunqun Huang, Yi Guo, Depan Shi
-
Patent number: 9718746Abstract: The present invention is a process for removing oxygenated contaminants from an ethylene stream comprising: a) providing a dried ethylene stream (A) comprising essentially ethylene, up to 1 w % oxygenates, ethane, CO, CO2, H2, CH4 and C3+ hydrocarbons, b) sending said stream (A) to a C2 splitter/deethanizer to produce a bottom stream comprising essentially ethane, oxygenates and C3+ hydrocarbons, an overhead comprising the remaining components, c) sending said overhead to a fixed bed CO2 adsorption zone to recover a stream essentially free of CO2, d) sending said stream essentially free of CO2 to a demethanizer/CO stripper to recover an overhead comprising H2, CH4 and CO, liquid ethylene at the bottoms. In another embodiment the CO2 removal step can be made on the recovered ethylene.Type: GrantFiled: July 13, 2012Date of Patent: August 1, 2017Assignees: Total Research & Technology Feluy, IFP Energies NouvellesInventors: Manuela Arratia, Catherine Boutrot
-
Patent number: 9718747Abstract: A process for removal of trace chloride contaminants from a reactor effluent in a catalytic dehydrogenation process is described. The reactor effluent is compressed in a compressor to provide a compressed effluent. The compressed effluent is introduced from the compressor into a chloride treater. In the chloride treater, trace chloride contaminants in the compressed effluent are adsorbed to provide a treated effluent. The treated effluent is cooled in a cooler.Type: GrantFiled: June 19, 2013Date of Patent: August 1, 2017
-
Patent number: 9718748Abstract: The present invention relates to methods of employing a metal-organic framework (MOF) as a catalyst for cleaving chemical bonds. In particular instances, the MOF results in selective bond cleavage that results in hydrogenolyzis. Furthermore, the MOF catalyst can be reused in multiple cycles. Such MOF-based catalysts can be useful, e.g., to convert biomass components.Type: GrantFiled: January 8, 2016Date of Patent: August 1, 2017Assignee: Sandia CorporationInventors: Mark D. Allendorf, Vitalie Stavila
-
Patent number: 9718749Abstract: The present invention is related to a novel and improved process for the preparation of 3,7-dimethylnonan-1-ol.Type: GrantFiled: March 11, 2014Date of Patent: August 1, 2017Assignee: DSM IP ASSETS B.V.Inventors: Werner Bonrath, Jonathan Medlock
-
Patent number: 9718750Abstract: A process is presented for the removal of acetaldehyde from mixture of oxygenates. Acetaldehyde is selectively removed in the presence of other oxygenates like ketones, alcohols and nitriles using an amorphous sodium doped alumina derived from thermally decomposed Dawsonite. The process successfully removes acetaldehyde which can adversely impact catalyst operation.Type: GrantFiled: November 11, 2016Date of Patent: August 1, 2017Assignee: UOP LLCInventors: Stephen Caskey, Vladislav I. Kanazirev
-
Patent number: 9718751Abstract: A process for preparing one or more reaction products, in which a first methane-rich feed stream is subjected to a partial oxidation process and/or an autothermal reforming process and a second methane-rich feed stream is subjected to a steam reforming process, in which a first synthesis gas-containing output stream is formed from the first methane-rich feed stream and a second synthesis gas-containing output stream is formed from the second methane-rich feed stream and these synthesis gas streams are used to form a collective synthesis gas stream and fluid from the collective synthesis gas stream is subjected to a molecular weight-increasing reaction in a synthesis feed stream to obtain a synthesis output stream comprising carbon dioxide and the reaction product(s). At least one carbon dioxide-rich first recycle stream is formed from fluid from the synthesis output stream and fluid from the first recycle stream is subjected to the steam reforming process.Type: GrantFiled: November 5, 2015Date of Patent: August 1, 2017Assignee: Linde AktiengesellschaftInventors: Andreas Peschel, Helmut Fritz, Thomas Bartesch, Johannes Fendt
-
Patent number: 9718752Abstract: The invention provides a process for the recovery of an alkylene glycol from an aqueous stream comprising the alkylene glycol and the corresponding dialkylene glycol, said process comprising the steps of providing the aqueous stream comprising the alkylene glycol and the corresponding dialkylene glycol, providing a first solvent stream, combining said aqueous stream comprising the alkylene glycol and the corresponding dialkylene glycol with said first solvent stream and recovering at least a portion of the alkylene glycol by liquid-liquid extraction, wherein said solvent comprises an amine.Type: GrantFiled: May 28, 2014Date of Patent: August 1, 2017Assignee: SHELL OIL COMPANYInventors: Kai Jürgen Fischer, Wouter Koot, Arlette Wesenhagen, Roel Guillaume Hubertus Leonardus Bastings
-
Patent number: 9718753Abstract: A compound is provided of Formula (I), wherein R1 represents a C3 to C20 hydrocarbon group derived from an alcohol of formula R1OH, from a formate of formula R1OCH?O, or a cinnamyl aldehyde of Formula (II) wherein a compound of Formula I is capable of releasing a compound, when oxidized, selected from the group consisting of a fragrant alcohol of formula R1OH, a fragrant formate ester of formula R1OCH=0 and aryl aldehyde of Formula (III), wherein R2 is, independently, hydrogen atom, hydroxyl group, optionally substituted C1-C6 alkyl group, C1-C6 alkoxy group, or -0(C=0)CH(CH3)2 wherein any two of R2 may form an optionally substituted 5 or 6 membered ring. The compounds are useful for example as a precursor for the prolonged delivery or release of fragrant compounds such as fragrant alcohols, fragrant aldehydes or fragrant formates.Type: GrantFiled: May 5, 2014Date of Patent: August 1, 2017Assignee: Firmenich SAInventors: Brinda Indradas, Gilbert Virtucio, Gary Womack
-
Patent number: 9718754Abstract: Disclosed is a process for the reductive carbonylation of a low molecular weight alcohol to produce the homologous aldehyde and/or alcohol. The process includes conducting the reaction to produce the aldehyde in the presence of a single component catalyst complex composed of cobalt, an onium cation and iodide in a ratio of 1:2:4 without additional promoters. A ruthenium co-catalyst is used in the production of the homologous alcohol. The reductive carbonylation reaction does not require an additional iodide promoter and produces a crude reductive carbonylation product substantially free of methyl iodide.Type: GrantFiled: May 13, 2016Date of Patent: August 1, 2017Assignee: Eastman Chemical CompanyInventors: Jonathan Michael Penney, David William Norman, Andrew James Vetter
-
Patent number: 9718755Abstract: The present invention provides methods for the production of terephthalic acid and derivatives thereof using ethylene oxide, carbon monoxide and furan as feedstocks. The process is characterized by high yields and high carbon efficiency. The process can utilize 100% biobased feedstocks (EO via ethanol, CO via biomass gasification, and furan via known processes from cellulosic feedstocks). In one aspect, processes of the invention coproduce biobased terephthalic acid and biobased styrene.Type: GrantFiled: June 30, 2016Date of Patent: August 1, 2017Assignee: Novomer, Inc.Inventors: Sadesh H. Sookraj, Jay J Farmer
-
Patent number: 9718756Abstract: This disclosure relates to a method of continuous recovery of (meth)acrylic acid and an apparatus used for the recovery method. The method of continuous recovery of (meth)acrylic acid according to the present invention may effectively remove scum formed in the continuous recovery process of (meth)acrylic acid, and simultaneously recover (meth)acrylic acid with excellent efficiency, thus enabling more stable operation of the continuous process.Type: GrantFiled: July 8, 2014Date of Patent: August 1, 2017Assignee: LG CHEM, LTD.Inventors: Se Won Baek, Jong Hun Song, Sul Hee Yoo, Yoon Jae Min
-
Patent number: 9718757Abstract: Methods and systems for the production and isolation of fatty acid methyl esters (FAMEs) from a lipid source are described. The method includes extracting a lipid from a lipid source and transesterifying the lipid into a FAME. The method may also include fractionating the FAME from the system. A method of selectively transesterifying a lipid into a FAME is also described.Type: GrantFiled: September 27, 2013Date of Patent: August 1, 2017Assignee: YALE UNIVERSITYInventors: Julie B. Zimmerman, Lindsay Soh
-
Patent number: 9718758Abstract: Disclosed is a method of reducing the ultraviolet-light absorbing properties of a composition comprising dioctyl phthalate, the method comprising (a) obtaining a composition comprising dioctyl phthalate and phthalide, wherein said composition has an absorbance of greater than 0.1 at a wavelength of about from 230 to 360 nm, (b) contacting the composition with activated carbon, silica gel, or diatomaceous earth, for a sufficient amount of time to allow the phthalide to contact the activated carbon, silica gel, or diatomaceous earth, and (c) removing the composition from the activated carbon, silica gel, or diatomaceous earth, wherein the composition obtained from step (c) has an absorbance equal to or less than about 0.1 at a wavelength of about from 230 to 360 nm and has a reduced amount of phthalide when compared with the composition from step (a).Type: GrantFiled: June 4, 2014Date of Patent: August 1, 2017Assignee: SAUDI BASIC INDUSTRIES CORPORATIONInventors: Mubarik Ali Bashir, Mohammad Rafi, Emmanuel Osei-Twun
-
Patent number: 9718759Abstract: The present invention relates to extracted plant lipid or microbial lipid comprising docosapentaenoic acid, and processes for producing the extracted lipid.Type: GrantFiled: June 18, 2015Date of Patent: August 1, 2017Assignees: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION, NUSEED PTY LTD, GRAINS RESEARCH AND DEVELOPMENT CORPORATIONInventors: James Robertson Petrie, Surinder Pal Singh, Pushkar Shrestha, Jason Timothy McAllister, Robert Charles De Feyter, Malcolm David Devine
-
Patent number: 9718760Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.Type: GrantFiled: October 31, 2013Date of Patent: August 1, 2017Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, EASTERN MICHIGAN UNIVERSITYInventors: Daniel A. Lawrence, Cory Emal, Ashley Reinke, Shih-Hon Li, Mark Warnock, Gregory Abernathy
-
Patent number: 9718761Abstract: The present invention provides a method for producing ?-hydroxyisobutyric acid amide by hydration of acetone cyanohydrin under the presence of a catalyst composed mainly of manganese oxide using a reactor in which at least two reaction regions are connected in series, the method being characterized by comprising: a step (B) of cyclically supplying at least a portion of a reaction liquid withdrawn from at least one reaction region to a first reaction region (I) in the reactor; and a step (b1) of further cyclically supplying at least a portion of the reaction liquid withdrawn from at least one reaction region to at least one reaction region other than the first reaction region. The method is also characterized in that an oxidizing agent is supplied to at least one reaction region in the reactor.Type: GrantFiled: July 15, 2014Date of Patent: August 1, 2017Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INCInventors: Atsushi Kakimi, Takako Uchiyama, Hideho Matsuda, Masaki Takemoto, Katsumi Higuchi
-
Patent number: 9718762Abstract: The present invention relates to novel triazole derivatives of formula (I) having insecticidal activity, to processes and intermediates for preparing them, to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests; wherein R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts thereof.Type: GrantFiled: October 24, 2013Date of Patent: August 1, 2017Assignee: Syngenta Participations AGInventors: Ottmar Franz Hueter, Pierre Joseph Marcel Jung, Thomas Pitterna, Helmars Smits, Andre Stoller
-
Patent number: 9718763Abstract: A process of preparing olefins of the formula (I) is described herein: with R1 being a substituted or unsubstituted (C1-C30)hydrocarbyl, and R2 being a substituted or unsubstituted (C1-C20)hydrocarbyl. The process includes reacting a compound of formula (II) wherein Ar is chosen from in the presence of a palladium-based catalyst and an organic solvent. A process of preparing olefins of the formula (III) is also described: with R3 being a substituted or unsubstituted (C1-C30)hydrocarbyl, R4 being a substituted or unsubstituted (C1-C20)hydrocarbyl, and R5 being a substituted or unsubstituted (C1-C30) hydrocarbyl. The process includes reacting a compound of formula (IV) wherein Ar is chosen from with a compound of formula (V) wherein Ar is chosen from in the presence of a palladium-based catalyst and an organic solvent.Type: GrantFiled: January 7, 2016Date of Patent: August 1, 2017Assignee: Regents of the University of MinnesotaInventors: William Baker Tolman, Marc A. Hillmyer, Alex John, Levi Thomas Hogan
-
Patent number: 9718764Abstract: The present invention relates to compounds which are suitable as synthesis precursors for the production of electronically active materials for use in organic electroluminescence devices.Type: GrantFiled: February 24, 2014Date of Patent: August 1, 2017Assignee: Merck Patent GmbHInventors: Philipp Stoessel, Amir Hossain Parham, Anja Jatsch
-
Patent number: 9718765Abstract: A method of producing optically pure N-substituted-3-methoxy propionic acid is provided, which includes the steps of: reacting N-substituted-3-methoxy propionic acid represented by formula (III): with a chiral amine in a solvent to obtain a diastereomeric salt represented by formula (IV): subjecting the diastereomeric salt to a sequential washing process to obtain the optically pure N-substituted-3-methoxy propionic acid represented by one of formulae (Ia) and (Ib): wherein R1 is selected from the group consisting of C1-5 alkyl, C1-6 alkoxy and C6-10 aryloxy group, and R2 is selected from the group consisting of C2-5 alkyl, C6-8 cycloalkyl and C6-10 aryl.Type: GrantFiled: June 21, 2016Date of Patent: August 1, 2017Assignee: SCI Pharmtech, Inc.Inventors: Bo-Fong Chen, Yen-Chi Su, Yen-Wei Li, Feng-Hsu Li, Chen-Wei Huang
-
Patent number: 9718766Abstract: One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.Type: GrantFiled: September 15, 2015Date of Patent: August 1, 2017Assignee: Techfields Pharma Co., Ltd.Inventors: Chongxi Yu, Lina Xu
-
Patent number: 9718767Abstract: A process includes reacting, in a reactor having a fixed bed containing a solid catalyst which contains a heterogeneous ion exchange resin, hydrogen sulfide and ethylene oxide in the presence of the solid catalyst to yield a reaction product which contains beta-mercaptoethanol. A reactor system includes the reactor, an ethylene oxide stream, a hydrogen sulfide stream, a fixed bed containing the solid catalyst placed in the reactor, and an effluent stream containing the reaction product. During steady state operation of the reactor in the process and the reactor system, the hydrogen sulfide and the ethylene oxide are present in a mole ratio in a range of about 9:1 to about 20:1.Type: GrantFiled: December 4, 2015Date of Patent: August 1, 2017Assignee: Chevron Phillips Chemical Company LPInventors: Daniel M. Hasenberg, Alex Pauwels
-
Patent number: 9718768Abstract: The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.Type: GrantFiled: April 12, 2012Date of Patent: August 1, 2017Assignee: ADC Biotechnology Ltd.Inventor: David Evans
-
Patent number: 9718769Abstract: Pulverulent compositions of a complex between an acid and a metal form an at least partially spherical particle. The acid is selected from 2-hydroxy-4-methyl-thiobutanoic acid (HMTBA), methionine, aspartic acid, the alginic acids, the pectinic acids, and the corresponding anions, in particular 2-hydroxy-4-methyl-thiobutanoate, methioninate, aspartate, the alginates and the pectinates. The metal is divalent or trivalent. The particle has an amorphous fraction the mass of which represents at least 50% of the total mass of the particle. The particle is substantially devoid of uncomplexed acid or anion and of uncomplexed metal or metal cation.Type: GrantFiled: March 15, 2013Date of Patent: August 1, 2017Assignee: INNOV'IA 3IInventors: Pierre Buisson, Robert Huet, Sebastien Fournier, Jean-Eudes Vendeville
-
Patent number: 9718770Abstract: The invention provides a compound of Formula I, an isomer, a pharmaceutically acceptable salt, or a solvate thereof, and use thereof in manufacture of a medicament for preventing and/or treating a drug-resistant tumor or disease or disorder caused by a drug-resistant bacterium, or use thereof in manufacture of a medicament for preventing and/or treating a tumor, a neurodegenerative disease, an allogeneic graft rejection, or an infection-associated disease or disorder; preferably, the tumor, neurodegenerative disease, allogeneic graft rejection, or infection-associated disease or disorder is a disease or disorder caused by Heat shock protein 70 (Hsp70). The compounds of the invention, which are a class of Hsp70 inhibitors having a novel structure and a high activity, solve the problem concerning drug resistance of tumors, enhance the effect of treating tumors, and provide a new medical strategy for treatment of tumors in clinic.Type: GrantFiled: December 18, 2014Date of Patent: August 1, 2017Assignee: Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. ChinaInventors: Wu Zhong, Song Li, Yanqun Zeng, Junhai Xiao, Xinbo Zhou, Zhibing Zheng, Xingzhou Li, Xiaokui Wang
-
Patent number: 9718771Abstract: A compound having an S1P1 receptor antagonistic activity. A compound represented by general formula (I): (in the formula, R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo C1-6 alkyl group or the like, R4 is a C1-6 alkyl group or the like, R5 is a C1-6 alkyl group or the like, R6 is a C1-6 alkyl group or the like, R7 is a hydrogen atom, a halogen atom, a C1-6 alkyl group or the like, R8 is a halogen atom, a C1-6 alkyl group, a halo C1-6 alkyl group, a C1-6 alkoxy group or the like, and R9 is a hydrogen atom or a C1-6 alkyl group.) or a pharmaceutically acceptable salt thereof, a pharmaceutical compositions containing same, and use thereof. The compounds have an excellent S1P1 receptor antagonistic activity and are useful for the treatment or prevention of autoimmune diseases.Type: GrantFiled: February 27, 2015Date of Patent: August 1, 2017Assignee: KISSEI PHARMACEUTICAL CO., LTD.Inventors: Hitoshi Inoue, Kohsuke Ohno, Tetsuya Nakamura, Yusuke Ohsawa
-
Patent number: 9718772Abstract: Crystalline (3Z,5S)-5-(hydroxymethyl)-1-[(2?-methyl-1,1-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime is disclosed. A pharmaceutical composition containing the crystalline compound and methods for treating conditions related to the OT-R activity, such as preterm labor, and tor increasing embryo implantation rate in a mammal undergoing embryo transfer, comprising administering the crystalline compound are also disclosed.Type: GrantFiled: June 10, 2015Date of Patent: August 1, 2017Assignee: ObsEva S.A.Inventor: André Chollet
-
Patent number: 9718773Abstract: Novel substituted 5 membered heterocyclic compounds of Formula I are disclosed. The invention further discloses a process for the preparation of compounds of Formula I. The compounds find use as anti mycobacterial agents.Type: GrantFiled: January 5, 2015Date of Patent: August 1, 2017Assignee: Council of Scientific and Industrial ResearchInventors: Ravindra Dattatray Aher, Boopathi Senthil Kumar, Arumugam Sudalai, Komal Girdhari Lalwani
-
Patent number: 9718774Abstract: The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5 and R6 are as defined in the description, their preparation and their use as pharmaceutically active compounds.Type: GrantFiled: December 11, 2013Date of Patent: August 1, 2017Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Kurt Hilpert, Francis Hubler, Thierry Kimmerlin, Dorte Renneberg, Simon Stamm
-
Patent number: 9718775Abstract: Compounds that are derivatives of oxindole conform to the general structure of Formula (I) These compounds are believed to exhibit antioxidant properties. A composition comprises an organic material and a compound conforming to the structure of Formula (I).Type: GrantFiled: February 4, 2015Date of Patent: August 1, 2017Assignee: Milliken & CompanyInventors: Sanjeev K. Dey, Eduardo Torres, Suchitra Datta, Mary E. Mason, Philip G. Harris
-
Patent number: 9718776Abstract: A benzilic acid ester compound represented by the following formula (I) or a salt thereof, wherein R represents optionally substituted fluorinated lower alkyl, is disclosed.Type: GrantFiled: May 29, 2014Date of Patent: August 1, 2017Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Masato Nanri, Kazuharu Noguchi, Fukumitsu Sakakibara, Shinichi Aoki