Abstract: There is disclosed a device and method for delivering constant target current to a muscle for electro-stimulation of that muscle. One device is a completely self-contained device with no external means for the adjustment and control of the electro-stimulation delivered to the muscle during treatment. The microprocessor based device monitors indirectly the actual current delivered to the muscle during electro-stimulation via measurement of the return path voltage through the muscle and optionally in addition monitors and adjusts for the internal battery voltage during use of the device in order to deliver a more consistent an accurate and effective target output current to the muscle being stimulated at each and every pulse delivered from the device. The device is pre-programmed with an electro-stimulation treatment cycle and the whole treatment cycle, including the monitoring and adjustment required to achieve this treatment cycle, is automatic within the device.

Abstract: Equipment for applying active elements to a cranium of a patient comprises a support and a plurality of active elements, wherein the support comprises a means of connection with a patient and means for positioning the active elements in order to excite N+M zones of the cranium, the N+M zones comprising the zones VG19, VG20, VG21, C4, C5R, C5L, C6R and C6L, N and M being two integer numbers, N being a number between 2 and 8, M being less than N/2.

Abstract: A system for providing non-invasive neuromodulation to a patient includes a mouthpiece and a controller. The mouthpiece includes an elongated housing, a printed circuit board, control circuitry mounted within the elongated housing, and a cable for connecting to a controller. The controller includes an elongated u-shaped element, an electronic receptacle, and a microcontroller. A method for providing non-invasive neurorehabilitation of a patient including connecting a mouthpiece to a controller, transmitting a numeric sequence to the mouthpiece, generating a first hash code, transmitting the first hash code to the controller, generating a second hash code, comparing the second hash code with the first hash code, enabling electrical communication between the mouthpiece and the controller only if the first hash code matches the second hash code, contacting the mouthpiece with the patient's intraoral cavity, and delivering neurostimulation to the patient's intraoral cavity.

Abstract: A device for disinfecting and/or sterilization of a dental cavity includes: an electrode pair that extends into the cavity to provide current along a portion of the cavity; and a controller that sends controlled electrical energy to the cavity via current flowing between the electrodes when located in the cavity, thereby to provide electrical energy for disinfection and/or sterilization.

Abstract: A method and system of providing therapy to a patient using electrodes implanted adjacent tissue. The method comprises regulating a first voltage at an anode of the electrodes relative to the tissue, regulating a second voltage at a cathode of the electrodes relative to the tissue, and conveying electrical stimulation energy between the anode at the first voltage and the cathode at the second voltage, thereby stimulating the neural tissue. The system comprises a grounding electrode configured for being placed in contact with the tissue, electrical terminals configured for being respectively coupled to the electrodes, a first regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, a second regulator configured for being electrically coupled between an anode of the electrodes and the grounding electrode, and control circuitry configured for controlling the regulators to convey electrical stimulation energy between the anode and cathode.

Abstract: A method of treating heart failure in a patient is disclosed that includes implanting a stimulation device into the identified patient to electrically stimulate the spinal cord, and activating the device to deliver electrical stimulation to the spinal cord.

Abstract: An electrode (10) for treating organic tissue by means of direct current, comprising an electrode holder (20), at least one electrically conductive electrode surface (30), which is let into the electrode holder (20), wherein the at least one electrode surface (30) is connected to at least one control element (400) and wherein the at least one control element (400) is connected to a control and energy supply unit by way of electrical lines (60, 70), wherein the at least one control element (400) is configured in such a way that each individual electrode surface (30) is actuable by the at least one control element (400) in such a way that a current density (J) provided within a predetermined interval for each one of the at least one electrode surfaces (30) can be maintained or that a current density (J) for each one of the at least one electrode surfaces (30) can be maintained around a predetermined value.

Abstract: Described is a container (1) for electrodes (E) to be used preferably in apparatuses for stimulating the human body and in the health sector, which allows a signal to be sent to the user upon the reaching, by an inside environment (3) of the container, of at least one temperature threshold, the reaching of which can produce negative effects on the components of the product which are perishable by heat, in such a way as to adversely affect the correct operation before the nominal expiry date indicated.

Abstract: Disclosed is a sheet mask for iontophoresis including: a first boring portion which is formed at least one portion of portions corresponding to eyes, a nose, and a mouth of a user face; and a second boring portion which is formed to connect an electrode portion, wherein the number of second boring portions is one to six.

Abstract: This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.

Abstract: Apparatuses and methods are disclosed that may be used to treat one or more restless leg syndrome (RLS) symptoms of a patient. One example method may include generating first and second stimulation waveforms using a waveform generator; electrically stimulating at least a portion of a sacral region of the patient, based on the first and second stimulation waveforms, using a number of electrodes; damping or interfering with electrical signals transmitted from the patient's brain to the patient's legs via a femoral nerve of the patient using the electrical stimulation; and reducing the one or more symptoms of RLS based on damping or interfering with the electrical signals transmitted from the patient's brain.

Abstract: Applying therapeutic neural stimuli involves monitoring for at least one of sensory input and movement of a user. In response to detection of sensory input or user movement, an increased stimulus dosage is delivered within a period of time corresponding to a duration of time for which the detected sensory input or user movement gives rise to masking, the increased stimulus dosage being configured to give rise to increased neural recruitment.

Abstract: The present invention is a system and method for providing an electrical stimulation signal to condition the pelvic wall muscles of a user and demonstrate to the user the proper muscle usage. The system and method also provides a system for measuring the users muscle response. The system and method also provides an entertaining interaction environment which encourages the user to perform self-initiated conditioning exercises.

Abstract: Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.

Abstract: A system for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. The system may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.

Abstract: A method and system for creating shear stress and endothelial mechanotransduction through neuromuscular stimulation of the muscle pump. Chronic application a minimum of 30 days triggers the autocrine and paracrine processes which elevates production of vasoactive substances including nitric oxide, prostacyclin, superoxide dismutase, thrombomodulin, glutathion, Krupple-like factor 2 and many others. Chronic application also promotes angiogenesis and development of collateral circulation. This is a cost-effective, non-invasive, drug-free therapy to treat vascular dysfunction and ameliorate or reverse its effects on cardiovascular health.

Abstract: An electrostimulation apparatus may comprise a control unit, a power supply and a carrier separated or combined. The control unit is configured to provide the electrical current to an electrode layer settled on or inside the carrier, and the power supply is configured to heat a heating piece settled on or inside the carrier. The carrier has a plurality of connecting portions which are configured to electrically connect to the control unit, the power supply, the heating piece and the electrode layer. Furthermore, the electrode layer is electrically connected to the control unit through the connecting portions, and also the heating piece is electrically connected to the power supply through the connecting portions. Also, the heating piece and the electrode layer are attached on the carrier, and the carrier can be used to serve both training and treatment purposes for a user.

Abstract: An electrical stimulation device is provided. According to one embodiment of the present invention, the electrical stimulation device for applying an electrical stimulation to the skin of a user comprises: a patch layer, which is a single patch layer and makes contact with the skin of the user when the electrical stimulation device is worn by or attached to the user; and a plurality of patch segments formed to be spaced apart from each other on the patch layer and transmitting current to the patch layer.

Abstract: In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents.

Abstract: A method of configuring a local brain stimulation tool is disclosed. The method comprises: obtaining a reference brain network activity (BNA) pattern, and a BNA pattern describing a neurophysiological state of the subject, each of the BNA patterns having a plurality of nodes and each node representing a brain location and at least one brain wave frequency. The method further comprises comparing the BNA patterns; and configuring the local brain stimulation tool to apply local brain stimulation at a frequency selected based on the comparison.

Abstract: Wires and coils within an electrode assembly electromagnetically interact and cause mechanical motion of the assembly. This mechanical motion can be used to supplement or replace the electrical stimulation provided by a standard cochlear implant and provides targeted acoustic stimulation to the cochlea.

Abstract: The present disclosure provides a spinal cord stimulation (SCS) system. The system includes at least one SCS lead including a lead body, at least one distal electrode located at a distal end of the lead body, the at least one distal electrode configured to apply electrical stimulation to a stimulation target of a patient, and a pain reduction assembly coupled to the lead body and configured to reduce post-operation pain at an incision site associated with implantation of the at least one SCS lead. The system further includes a pulse generator coupled to the at least one SCS lead and configured to control electrical stimulation delivered to the patient via the at least one SCS lead.

Abstract: A method of providing therapy to a patient using a plurality of electrodes is provided. The electrodes are located adjacent a target neural tissue region having a first nerve fiber of a relatively small diameter and a second nerve fiber of a relatively large diameter. The method comprises sourcing electrical current from a local anode into the target neural tissue region. The method further comprises therapeutically sinking a first portion of the electrical current from the target neural tissue region into a local cathode. The method further comprises sinking a second portion of the electrical current into a cathode remote from the target neural tissue region. The ratio of the sourced electrical current over the first sunk electrical current portion has a value that allows the first nerve fiber to be recruited by the electrical current while preventing the second nerve fiber from being recruited by the electrical current.

Abstract: Methods and systems are provided for a rate adaptive bi-ventricular fusion pacing. The methods and systems deliver a first pulse at a left ventricular (LV) lead and a second pulse at a right ventricular (RV) lead based on a paced atrio-ventricular (AV) delay. The first pulse timed to be delivered concurrently with an intrinsic ventricular conduction. The methods and systems further repeat the delivery of the first pulse and the second pulse for a predetermined number of cycles. Additionally, the methods and systems measure an intrinsic AV conduction interval, and adjust the paced AV delay based on the intrinsic AV conduction interval and a negative hysteresis delta.

Abstract: Disclosed is a new architecture for an IPG having a master and slave electrode driver integrated circuits. The electrode outputs on the integrated circuits are wired together. Each integrated circuit can be programmed to provide pulses with different frequencies. Active timing channels in each of the master and slave integrated circuits are programmed to provide the desired pulses, while shadow timing channels in the master and slave are programmed with the timing data from the active timing channels in the other integrated circuit so that each chip knows when the other is providing a pulse, so that each chip can disable its recovery circuitry so as not to defeat those pulses. In the event of pulse overlap at a given electrode, the currents provided by each chip will add at the affected electrode. Compliance voltage generation is dictated by an algorithm to find an optimal compliance voltage even during periods when pulses are overlapping.

Abstract: Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.

Abstract: A method of downregulating and/or upregulating neural activity by applying a high frequency alternating current electrical signal to a nerve in a subject is disclosed. The signal comprises more than one microsecond cycle comprising one or more periods, each period comprising a charge recharge phase, and optionally, a pulse delay, each period having a frequency of at least 1000 Hz; and a microsecond inactive phase. In embodiments, an electrical signal treatment comprises more than one microsecond cycle to form a millisecond cycle, each millisecond cycle separated by a millisecond inactive phase during an on time. In embodiments, the electrical signal patterns can differ in amplitude.

Abstract: An implantable medical device includes an enclosure having a sidewall and a welded seam in the sidewall, the seam extends along a perimeter of the enclosure. A thermoform is located adjacent a surface of the enclosure and is secured in place within the enclosure. A metalized surface is located adjacent an interior surface of the enclosure sidewall and is secured in place by the thermoform. The metalized surface extends along a perimeter of the enclosure and is configured to obstruct laser energy during a weld seam process. The metalized surface may be provided as a separate backup band component or may be integrated in a perimeter sidewall of the thermoform.

Abstract: A connector for an implantable electrical medical device includes an elongated connector body; a connector lumen to receive a lead or lead extension; a non-conductive carrier disposed in the connector body and including at least two rails extending parallel to the connector lumen and pairs of contact holders spaced-apart along the rails; contacts with each contact disposed between one of the pairs of contact holders; and connector conductors coupled to the contacts. Instead of carrier and contacts, the connector can include contact assemblies, each contact assembly including a non-conductive contact carrier defining two nodes, and two contacts, each contact disposed in one of the two nodes, each contact including a coil and a sheath disposed around at least a portion of the coil. Another alternative includes a non-conductive carrier with contact openings; and contacts, where each contact is a rod disposed in one of the contact openings.

Abstract: A feedthrough for a cochlear implant or other medical device can include contacts disposed on an outer perimeter thereof. By disposing the contacts on the perimeter, the number of contacts on the feedthrough can be increased, the size of the feedthrough reduced, or both.

Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Abstract: This disclosure provides systems and methods for delivering a neural stimulation pulse. A neural implant device can include an energy harvesting circuit configured to receive an input signal and generate an electrical signal based on the received input signal. A diode rectifier in series with the energy harvesting circuit can rectify the electrical signal. The energy harvesting circuit and the diode rectifier can be encapsulated within a biocompatible electrically insulating material. A neural electrode can be exposed through the biocompatible electrically insulating material. The neural electrode can be configured to deliver a neural stimulation pulse. The neural implant device can have a volume that is less than about 1.0 cubic millimeter.

Abstract: The invention relates to a method for supplying an electrical energy-converting implant with electrical energy, wherein an electrical voltage source is provided, wherein electrical voltage is generated by the linear movement of a piston of a free-piston generator.

Abstract: Devices, systems, and methods for coupling with an implantable neurostimulator for delivering one or more electrical pulses to a target region within a patient's body are disclosed herein. A device, such as a charger, can include: a power source for storing electrical energy; a resonant circuit that can have a plurality of selectable natural frequencies; a driver coupled to the power source and the resonant circuit; and a processor coupled to the resonant circuit to control the natural frequency of the resonant circuit. The processor can control the natural frequency of the resonant circuit according to stored data associated with the implantable neurostimulator.

Abstract: Systems, apparatus, methods and computer-readable storage media facilitating telemetry overuse reduction in an implantable medical device (“IMD”) are provided. In one embodiment, an IMD includes a housing configured to be implanted at least partially within a patient, a memory and circuitry within the housing and a processor that executes executable components stored in the memory.

Abstract: Systems, apparatus, methods and computer-readable storage media that facilitate monitoring the integrity of telemetry connectivity between an implantable device and an external device are provided. In one embodiment, an implantable device includes a monitoring component that monitors advertisement signal information identifying an amount of advertisement signals transmitted to the external device within a defined time period, and telemetry session information identifying an amount of the telemetry sessions that are established between the external device and the implantable device within the defined time period. A connectivity assessment component of the implantable device further determines whether a telemetry connectivity problem exists between the external device and the implantable device based on a degree of miscorrelation between the advertisement signal information and the telemetry session information.

Abstract: A dynamically adjustable multiphasic pulse system and method are provided. The dynamically adjustable multiphasic pulse system may be used as pulse system for a defibrillator or cardioverter.

Abstract: A wearable medical device comprising: a plurality of patient interface components each configured to interface with a patient; a first patient interface component of the plurality of patient interface components, the first patient interface component comprising a first sensing electrode for receiving one or more signals from a first patient, and a first therapy electrode for delivering a first treatment to the first patient; a second patient interface component of the plurality of patient interface components, the second patient interface component comprising a second sensing electrode for receiving one or more signals from a second patient; and one or more processors in communication with the plurality of patient interface components, the one or more processors configured to detect a first condition of the first patient based at least in part on the one or more signals from the first patient, cause the first treatment to be delivered to the first patient, wherein the first treatment is based at least in part

Abstract: Disclosed is a device (1) for biologically decontaminating percutaneous accesses or the stomata of patients, by means of a plasma generator (4) for generating a decontaminating plasma adjacently to a treatment surface (3) of the plasma generator (4). In order to at least partially surround a percutaneous access or stomata, the treatment surface (3) is curved to be adaptable and can be placed against the percutaneous access or stoma.

Abstract: A non-thermal plasma for use in the treatment of an infected nail or infected skin. The plasma is used in the method by (a) applying the plasma to the infected nail or skin; (b) rehydrating the infected nail or skin; (c) applying the plasma to the infected nail or skin; and (d) optionally rehydrating the infected nail or skin. In each of steps (a) and (c) the plasma is applied to a portion of the nail or skin until a hydration level of the plasma-treated portion drops by at most 30 wt % based on the initial moisture content of the plasma-treated portion.

Abstract: An illuminator for photodynamically diagnosing or treating a surface includes a plurality of panels. The illuminator further includes a plurality of light sources, each mounted to one of the plurality of panels. The plurality of light sources are configured to irradiate the surface with substantially uniform intensity visible light. The illuminator also includes a heat source configured to emit heat to a patient.

Abstract: Various types of low level laser therapy (LLLT) wrap devices, methods of use, and a system comprising a mobile application, for the treatment of pain from musculoskeletal injuries or medical conditions, and to capture “patient's vitals”. Each wrap is fitted to a specific body part (e.g. knee), lightweight, portable so that it is wearable beneath clothing; and with a battery-powered electrical circuit embedded within the wrap, comprising: a plurality of laser diodes to treat surface and/or deep tissue pain; sensors (e.g. safety and/or patient vital sign monitoring); and a wireless transceiver for transmitting data (sensor and patient pain levels) to a mobile application. The wrap may also function as an orthopedic support; and is pre-calibrated for a specific duration to deliver a clinical strength dosage from 630 nm to 904 nm that is specific to the medical disorder and/or the user anatomical area, with an automatic shut-off after dose delivery.

Abstract: A method for testing diseased skin for treatment of the diseased skin, comprising the steps of administering a plurality of increasing doses of phototherapy directly to regions of an area of diseased skin and analyzing the area of the diseased skin to assess the doses at which burning and blistering of the diseased skin occurs, determining a maximum dose of phototherapy that can be administered to the diseased skin based on the assessment of the doses at which the burning and the blistering of the diseased skin occurs, and treating the diseased skin.

Abstract: The present invention is concerned with a skin treatment device, in particular a temporal hair removal device, having a light emission unit having a substrate, a plurality of first LED dies mounted on the substrate on an area of at least 0.2 cm2, in particular of at least 1.

Abstract: A device and method are provided for modulating brain inflammation. The device includes a light source positionable at a location adjacent a portion of brain for modulating the inflammation thereof The light source has a first off condition and second on condition wherein the light source generates light having a wavelength in the range of 450-495 nanometers (nm). A controller is operatively connected to the light source. The controller provides control signals to the light source for controlling the switching of the light source between the on and the off conditions. The controller is configured to switch the light source to the on condition for a portion of a treatment cycle.

Abstract: A therapeutic illumination assembly includes a catheter and a point source treatment fiber. The catheter comprises a catheter wall encircling a luminal fluid pathway. The point source treatment fiber is positioned within the luminal fluid pathway of the catheter. Further, the point source treatment fiber comprises a plurality of light emitting point sources intermittently positioned along a treatment length of the point source treatment fiber such that the plurality of light emitting point sources irradiate the catheter when the plurality of light emitting point sources emit light.

Abstract: A spot determination unit classifies an irradiation region to be irradiated with a charged particle beam into a plurality of layers in an irradiation direction of the charged particle beam, and arranges a plurality of irradiation spots in the plurality of layers. The irradiation spots are classified into groups in accordance with at least either a distance between one irradiation spot and another irradiation spot which are arranged in the same layer or a target irradiation dose of each irradiation spot. A plan is prepared for continuously emitting the charged particle beam while the irradiation position is changed from an irradiation spot belonging to a certain group to a subsequent irradiation spot, and so as to stop emitting the charged particle beam while the irradiation position is changed from an irradiation spot belonging to a certain group to an irradiation spot belonging to another group located in the same layer.

Abstract: A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic, ferromagnetic, or ferrimagnetic properties.

Abstract: Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information.

Abstract: A medical system includes a medical device and a controller. The medical device is controlled according to a control protocol. The controller is configured to receive a measured data set containing a current value at a current time and past values at past times of a physiologic signal measured on a recipient, calculate a difference signal at the current time based on the measured data set, and predict a difference value using the difference signal and a prediction algorithm. The difference value is a difference between a predicted future value of the physiologic signal at a future time and the current value. The controller is further configured to calculate the predicted future value based on the difference value and the current value and update the control protocol according to the predicted future value.