Abstract: A biological information measurement apparatus includes an irradiation unit configured to irradiate a living body with light or sound waves as measurement waves; a detection unit configured to detect the measurement waves having passed through the inside of the living body; and a computational unit configured to obtain a change over time in blood flow rate and a change over time in blood vessel cross-sectional area based on a detection result from the detection unit, and to obtain a pulse wave propagation velocity from the change over time in blood flow rate or the change over time in blood vessel cross-sectional area.

Abstract: An optical sensing system is disclosed. The optical sensing system includes a printed circuit board (PCB), a supporter and an optical sensor. The PCB includes a top surface, a bottom surface and a through cavity, wherein the through cavity extends downwardly from the top surface to the bottom surface. The supporter has a top surface and a bottom surface. The optical sensor is bonded and coupled to the top surface of the supporter, wherein the optical sensor includes a primary optic structure. Wherein the supporter is flipped over and bonded to the PCB with the top surface facing the through cavity, so that the optical sensor is coupled to the PCB and at least partially extends to the through cavity. Associated electronic devices are also disclosed.

Abstract: A biological information measuring device includes: a pulse wave sensor unit which detects a pulse wave of a living body and outputs a pulse wave signal; an MCU which generates heart rate information and time information; a storage unit capable of storing the heart rate information; operation buttons which output an operation signal corresponding to an input operation by a person; and a display unit.

Abstract: A data acquisition system for use with expandable ECG electrode systems. The data acquisition system includes a main unit and one or more expansion units for increasing the number of ECG leads applied to a patient for enhanced monitoring capabilities. Multiple embodiments are illustrated for providing a common mode signal between the main electrode unit and expansion units without requiring the physical transmission of voltage potential between the main unit and the expansion unit. In one embodiment, the main unit and the expansion unit share a common ground reference potential. In a second embodiment, an optical signal is transmitted between the main unit and the extension unit to relay the common mode information while in a third embodiment, common electrode potentials are provided to both the main unit and the extension unit for constructing their own common reference signal.

Abstract: Embodiments of the disclosure include systems and methods for reducing false positives in detection of pauses. For example, embodiments include a sensing component configured to obtain values of a first physiological parameter and determine a cardiac pause based on the values of the first physiological parameter. Furthermore, embodiments include performing a validation check of the determined cardiac pause using at least one of: the values of the first physiological parameter or values of a second physiological parameter.

Abstract: The present invention provides a biological electrode including an electro-conductive base material and a living body contact layer formed on the electro-conductive base material; wherein the living body contact layer includes a resin layer and particles dispersed in the resin layer, the particles being coated with gold, silver, or platinum, and a thickness of the resin layer is equal to or thinner than an average particle size of the particles. The biological electrode of the present invention is superior in electric conductivity and biocompatibility, light in weight, and can be manufactured at low cost.

Abstract: An automatic method of determining local activation time (LAT) from at least three multi-channel cardiac electrogram signals including a mapping channel and a plurality of reference channels. The method comprises (a) storing the cardiac channel signals, (b) using the mapping-channel signal and a first reference-channel signal to compute LAT values at a plurality of mapping-channel locations, (c) monitoring the timing stability of the first reference-channel signal, and (d) if the timing stability of the monitored signal falls below a stability standard, using the signal of a second reference channel to determine LAT values. Substantial loss of LAT values is avoided in spite of loss of timing stability.

Abstract: Methods and system for assessment of a state of the central nervous system (CNS) of a subject and/or differentiation between states of the CNS at a specific time point based on electrophysiological recordings of signals from at least two anatomical structures, wherein the signals are recorded from recording sites located in the anatomical structures, wherein the electrophysiological recordings comprise spatiotemporal fluctuations in the recorded extracellular potential, wherein the electrophysiological recordings are action potentials and/or local field potentials (LFPs) in the anatomical structures and represent the state of the CNS, a s well as the use of the method for assessment of a state of the CNS and/or differentiation of at least two states of the CNS, as well as to the use of the method for evaluating the effect of a treatment of a condition or disease, wherein the condition or disease is neurological and/or psychiatric.

Abstract: A cardiac monitoring and/or stimulation system includes a housing coupled to a plurality of electrodes configured for subcutaneous non-intrathoracic sensing. A signal processor receives a plurality of composite signals associated with a plurality of sources, separates a signal from the plurality of composite signals, and identifies the separated signal as a cardiac signal using information derived from a non-electrophysiologic sensor, such as an accelerometer or acoustic transducer. The signal processor may iteratively correlate separated signals from the plurality of composite signals with a non-electrophysiologic sensor signal until the cardiac signal is identified.

Abstract: A system and method for a multichannel voltage recording device is described. A multichannel voltage recording device comprises at least three electrodes disposed across a conductive material. The electrodes are configured to be coupled to a skin of a user. A frame comprises the conductive material that is configured to receive a driven right leg (DRL) signal based on the voltage signals from the at least three electrodes.

Abstract: A wearable electrocardiography monitoring ensemble is provided, which includes a garment made of a compressible and elastomeric material. The garment is wearable about an upper region of the torso and further includes an internal structure forming a compressive bias circumferential to the torso. The ensemble also includes an electrode assembly provided on an inside surface of the garment on an underside of the internal structure. The electrode assembly has a pair of electrocardiography electrodes, a pair of terminated electrical connections that are each coupled to one of the electrocardiography electrodes, and a backing to which the electrocardiography electrodes are affixed.

Abstract: The invention relates to a device comprising a number of electrode assemblies (10), which can be applied to the skin surface (4) of an animal or human being and by means of which voltages and currents can be tapped from the skin surface (4), and comprising a flexible, in particular extendable, retaining element (6) formed by a planar or film-like molded part. According to the invention, the electrode assemblies (10) comprise a main body (1) and a number of pin electrodes (2) that protrude from the main body (1) in the same direction, the electrode assemblies (10) are fastened to the retaining element (6), and the main body (1) of the respective electrode assembly (10) is connected to the retaining element (6), wherein the pin electrodes (2) of all electrode assemblies (10) protrude in the same direction.

Abstract: Physiological monitoring can be provided through a wearable monitor that includes two components, a flexible extended wear electrode patch and a removable reusable monitor recorder. The wearable monitor sits centrally (in the midline) on the patient's chest along the sternum oriented top-to-bottom. The placement of the wearable monitor in a location at the sternal midline (or immediately to either side of the sternum) benefits extended wear by removing the requirement that ECG electrodes be continually placed in the same spots on the skin throughout the monitoring period. Instead, the patient can place an electrode patch anywhere within the general region of the sternum. Ensuring that the quality level of ECG recording remains constant over an extended period of time is provided through self-authentication of electrode patches. The monitor recorder implements a challenge response scheme upon being connected to an electrode patch. Failing self-authentication, the monitor recorder signals an error condition.

Abstract: A method for synchronizing an MR imaging process with a breathing rest state of a patient during an examination using held breath is provided. In the method, an instruction is output to the patient to hold his breath. In addition, the respiratory behavior of the patient is identified in real time. An MR imaging process is started according to the identified respiratory behavior. A breathing synchronization device and a magnetic resonance imaging system are also provided.

Abstract: Systems and methods for providing quantitative measurements of global glymphatic flow of cerebrospinal fluid (“CSF”) using magnetic resonance imaging (“MRI”) are described. In general, images are obtained from a subject using flow-sensitive MRI techniques that are designed to be particularly sensitive to the glymphatic flow of CSF. Measures of glymphatic flow can be obtained while the subject is in an awake state and again while the subject is in a sleep state. Based on these two measurements, a biomarker that indicates a neurological state or disease can be generated.

Abstract: A method of confirming the location of a target tissue within a patient using a navigation system is provided. The navigation system displays images from a pre-acquired image dataset and provides location information of a medical device within a patient in relation to a patient tracking device affixed to the patient. The method includes determining an initial location of the target tissue, navigating a steerable catheter through the airway of the patient to a position proximate the initial location, tracking the location of the steerable catheter in the airway using the navigation system, generating information regarding the presence of the target tissue using a tissue sensing device inserted into the steerable catheter, and determining a confirmed location of the target tissue in relation to the patient tracking device using the generated information regarding the presence of the target tissue and the tracked location of the steerable catheter.

Abstract: A method of detecting hypoxia. Detecting hypoxia includes detecting, in exhaled breath, at least one indicator for hypoxia. The at least one indicator is selected from the group consisting of pentanal, 2-pentanone, 2-hexanone, 2-heptanone, 2-cyclopenten-1-one, and 4-butyrolactone.

Abstract: A measurement apparatus which includes a processor is provided. The processor is configured to calculate, based on a distance image of a measurement target object with at least a joint, a position of a first portion of the measurement target object which corresponds to a non-joint portion or a terminal portion, and a position of a second portion of the measurement target object different from the first portion, and calculate, based on a first line connecting the calculated positions, a joint angle related to a joint of a first measurement target of the measurement target object.

Abstract: An orthodontic system and method for moving and aligning at least one tooth of a set of teeth of at least one of an upper jaw and a lower jaw of a patient. In the system and method an orthodontic appliance can be provided which may include a force exerting member for applying a force to and moving the at least one tooth, a tooth movement sensor member for obtaining at least one of tooth movement data, tooth position data, and tooth identification data, and a tooth movement monitor for calculating at least one of an amount of tooth movement and tooth position from the at least one of the tooth movement data, the tooth position data, and the tooth identification data obtained with the tooth movement sensor arrangement.

Abstract: A method for mapping the trajectory of a part of the anatomy of a human or animal body. The method comprises receiving first sensor signals from a sensor attached to part of the anatomy of the human or animal body. The first sensor signals comprise three dimensional position information indicating the location of the sensor; determining from the first sensor signals at least two angles of rotation of the part of the anatomy to which the sensor is attached with respect to a centre of rotation of another part of the body, wherein the angles of rotation are selected from pitch, yaw and roll. Transforming the signals to provide two dimensional coordinate data defined in a two dimensional coordinate space wherein a first dimension in the two dimensional coordinate space represents a first angle of rotation of the part of the anatomy and a second dimension in the two dimensional coordinate space represents a second angle of rotation of the part of the anatomy; and stores the two dimensional coordinate data.

Abstract: A system for evaluating the degree of brain dysfunction of a subject, such as a decline in cognitive function, calculates a difference in movement functions between both hands in a coordination movement. The system includes a storage device for storing time-series data on a finger movement task of each of both hands of a test subject acquired by a movement sensor; a data processing device for analyzing the time-series data stored in the storage device; and a display device for displaying an analysis result analyzed by the data processing device. The data processing device includes a movement waveform generation unit for generating a movement waveform corresponding to the time-series data stored in the storage device; and a difference-between-hands feature quantity generation unit for generating a difference-between-hands feature quantity which represents a difference in respective finger movement tasks between both hands, based on the respective movement waveforms of both hands.

Abstract: The present invention addresses the problem of limiting power consumption and radio wave interference when assessing the movements of multiple sites of a living body. The present invention is a movement function assessment system provided with: a movement function measurement apparatus for calculating movement data on the basis of the relative distances of pairs of transmission coils and reception coils attached to movable portions of a living body; and an assessment apparatus for assessing the movement function of the living body on the basis of the movement data received from the movement function measurement apparatus. A control unit of the movement function measurement apparatus performs the switching of the multiple transmission coils by a switching unit (1) and the switching of the multiple reception coils by a switching unit (2) so that the paired transmission coils and reception coils are operated sequentially.

Abstract: A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.

Abstract: Systems, devices, and methods are provided that enable the sensing of an analyte level within, e.g., the dermal layer of the skin of a subject. These systems, devices, and methods can utilize modalities that increase perfusion in an area local to a dermal sensor.

Abstract: Generally, methods of analyte monitoring management, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data and analyzing the analyte measurement data for health related parameters. Recommendations are determined for creating or modifying a treatment program based on the analysis, and provided within a user-interface that enables a user to create or modify the treatment program. Further, generally, methods of for managing analyte measurement data, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data that represent data collected over a time period, and analyzing the analyte measurement data for analyte episodes within that time period. Threshold based episodes and/or rate-of-change based episodes may be determined.

Abstract: Provided is a biological information measurement device, including: a blood index calculation unit which calculates at least part of a blood index associated with oxygen transport based on transmitted light or reflected light when a body part of a test subject is irradiated with light with a plurality of wavelengths; an oxygen consumption calculation unit which calculates an oxygen consumption based on a gas concentration in inspired air, a gas concentration in expired air, and a ventilation amount of the test subject; a cardiac output calculation unit which calculates a cardiac output based on a biological signal obtained by a noninvasive method from the test subject; and an SvO2 estimation unit which estimates the mixed venous oxygen saturation of the test subject by substituting the blood index, the oxygen consumption, and the cardiac output in a calculation formula.

Abstract: A wearable device includes an information acquisition section which acquires environmental information including at least one of location information of a user, atmospheric pressure information, and weather information, a sensor which acquires arterial oxygen saturation information, a processing section which generates notification information associated with an arterial oxygen saturation based on the environmental information and the arterial oxygen saturation information, and an output section which outputs the notification information.

Abstract: A measurement apparatus includes a first light emission unit that emits light having a first wavelength, a second light emission unit that emits light having a second wavelength of which an arrival depth with respect to a measurement site exceeds the arrival depth of the light having the first wavelength, a light reception unit that generates a detection signal corresponding to a light reception level of light arriving from the measurement site, and an analysis unit that acquires biological information corresponding to the detection signal. The first light emission unit, the second light emission unit, and the light reception unit are installed on a detection surface facing the measurement site, and a distance between the first light emission unit and the light reception unit exceeds a distance between the second light emission unit and the light reception unit.

Abstract: A blood sampling device contains: a body, a fitting sleeve, a triggering block, a trigger spring, and a switch. The body is hollow and fits with the fitting sleeve which includes an exit for extending a lancet out of the exit, and the body includes a first fixing position and a second fixing position. The first fixing position is an untriggering position away from the exit, and the second fixing position is a triggering position close to the exit. A first end of the triggering block abuts against the trigger spring, the triggering block includes a connecting orifice for accommodating the lancet and includes an elastic piece retaining at the first fixing position or the second fixing position. The switch is mounted on the body and includes a releasing segment corresponding to the first fixing position so as to release the elastic piece from the first fixing position.

Abstract: A blood sampling device contains: a body, a fitting sleeve, and an adjusting sleeve. The body includes a lancet, a driving edge for driving the lancet, a control switch for controlling the driving edge, and a connecting section. The fitting sleeve includes a first fitting section, a second fitting section, and a connecting groove, wherein the second fitting section has a coupling portion for connecting with the connecting section. The fitting sleeve further includes a trench, an outlet, and a fixing rib. The adjusting sleeve includes a coupling section, a controlling section opposite to the coupling section, a tilted guiding slot for retaining with the fixing rib, and an exit corresponding to the outlet, The second fitting section of the fitting sleeve has a transparent window for viewing the coupling section of the adjusting sleeve, and the coupling section has a length identification portion injection molded thereon.

Abstract: A needle assembly is disclosed. The needle assembly includes a housing having a flash chamber, and having a distal end and a proximal end engageable with a specimen collection container. The assembly includes a cannula having a patient end, a non-patient end, and a sidewall extending therebetween defining a cannula interior. The patient end of the cannula projects at least partially from the distal end of the housing, and the cannula interior is in fluid communication with the flash chamber. The assembly further includes a shield restrainably engaged with a portion of the housing and axially transitionable over the patient cannula from a retracted position in which the patient end is exposed, to an extended position in which the patient end is shielded by at least a portion of the shield, wherein at least a portion of the flash chamber is visible in the retracted position.

Abstract: System, apparatus and method for the management of stress of one or more users. One such system comprises providing an indication to a user based correlating physiological data, allostatic load data and psychological states. In some embodiments, information indicating one or more psychological states of a user is received. Physiological data may be obtained from sensors, which may be attached to a user for example via a wearable device or apparatus. Allostatic load data may be obtained via biosensing lab that analyzes bio data such as saliva or blood. The system may further comprise correlating one or more data sources and information sources to provide indicate and/or manage a user's stress levels.

Abstract: The present disclosure discloses a method and system for detecting visual attention. Embodiments of the present disclosure collect time sequences and corresponding pupil diameter sequences of each point of regard during visual attention process. Attention change curve is plotted according to the corresponding relationship between time sequences and pupil diameter sequences. The attention change curve is divided into four stages based on pre-setting time parameters and pupil diameter parameters. Numerical analysis of each stage is finished based on duration and rate of pupil change. Quantitative calculation of visual attention of each stage is realized, and the changing procedure of visual attention can be portrayed entirely, systematically and quantitatively.

Abstract: A method for improved seizure detection includes capturing neural data for a first set of brain regions; calculating inter-region correlations between pairs of the first set of brain regions from the neural data; detecting a period of hyposynchrony from the inter-region correlations; after detecting the period of hyposynchrony, detecting a period of hypersynchrony from the inter-region correlations; and based on a transition from the period of hyposynchrony to the period of hypersynchrony, detecting a first seizure.

Abstract: A cervical dilation reading apparatus and method of use to accurately and precisely determine cervical dilation measurements during labor and delivery. The apparatus includes a measuring device having a length with a first portion, a second portion, and a third portion, a first attachment band configured to couple with a first finger, the first attachment band having a fixed attachment fixedly engaged with the first portion of the measuring device, and a second attachment band configured to couple with a second finger, the second attachment band having a slidable attachment slidably engaged with the second portion of the measuring device.

Abstract: An apparatus for evaluating the tongue strength and coordination of a subject includes an intermediate device such as a lever which is pivotably attached to a coupling device and extends into a cavity of a nipple element. The lever is detached from the nipple and pivotable in response to deformation of the nipple element by a tongue force exerted on the nipple element by a subject during a suck-swallow-breathe sequence. The coupling device includes a sensing device to wirelessly transmit sensor outputs to a mobile device paired to the sensing device. The sensing device includes at least one sealed chamber defined by a membrane and a sensor. In one example, a first membrane and sensor senses pressure change in a fluid in the apparatus, and a second membrane and sensor is actuated by the intermediate device to sense deformation of the nipple element. A method using the apparatus is provided.

Abstract: A wearable device including a sensor system for Manual Wheelchair Users (MWCUs) to provide an alert to the MWCUs when there is an increased risk of injury is provided. The wearable device includes sensors measuring the physical activity of the MWCU and transmitting it as user data to a user motion dynamics analysis system on a user device. When the user motion dynamics analysis system determines that there is a risk of injury, it transmits an alert to the wearable device for display to the user.

Abstract: There is disclosed a process for determining early patient response to an initial therapy administration, comprising a rapid determination of effectiveness of a therapy after an initial treatment for a cancer indication. More specifically, the rapid determination of effectiveness is made days following initial therapy.

Abstract: A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a diffuser. The diffuser is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the diffuser.

Abstract: A patient monitor can noninvasively measure a physiological parameter using sensor data from a nose sensor configured to be secured to a nose of the patient. The nose sensor can include an emitter and a diffuser. The diffuser is configured to generate a signal when detecting light attenuated by the nose tissue of the patient. An output measurement of the physiological parameter can be determined based on the signals generated by the diffuser.

Abstract: A method of providing a channel in nervous tissue filled with an aqueous gel for implantation of a microelectrode or other medical device lacking sufficient physical stability for direct implantation by insertion, comprises providing an apparatus comprising an oblong rigid pin covered by a dry gel forming agent; locating a target in the tissue; defining a straight insertion path a desired tissue insertion point and the target; aligning the pin with its end foremost with the insertion path; inserting the pin into the tissue to a position near or at the target; allowing sufficient time to pass for a gel to be formed around the pin, withdrawing the pin. Also disclosed is a corresponding channel; a method of implantation of a microelectrode or microprobe into nervous tissue via the channel; a corresponding method of implantation of living cells; a corresponding apparatus for forming the channel.

Abstract: The present invention provides a coronary sinus inspiration catheter comprising a catheter head section and an extension tube, which are hollow tubular structures, the catheter head section and a distal section of the extension tube are substantially arc-shaped, the catheter head section comprises an arc section and a bend section, and its length is about 4-10 cm, the distal end is small (3-6 F) and the tube diameter of the catheter head section increase gradually toward the proximal end (6-12 F), the catheter head section is bent at a 15-45° angle at the position which has a distance of 0.5-1.5 cm from the distal end, the bend section is a straight or slightly arc-shaped structure. The catheter head section is provided with an end hole and a plurality of side holes, and is equidistantly provided with radiopaque markers from the distal end to the proximal end.

Abstract: The present invention relates to a catheter and method for detecting electrical activity in an organ. The catheter comprises: a proximal end with connection means for connecting to a signal processing system and a distal end for being inserted into a patient's organ, at least 3 arms extending from the distal end, each arm comprising at least one electrode. The catheter further comprises a central electrode at the distal end of the catheter. The method comprises: inserting a multi-electrode catheter into a patient's organ; obtaining and conditioning a positioning signal for positioning the electrodes; obtaining causal information about the current location; processing and summarizing the causal information obtained together with causal information about previous locations; visually presenting a recurrence plot of all the causal information obtained; and then moving the catheter to a new location and repeating the method until obtaining a complete recurrence plot.

Abstract: An arrangement is provided having a camera, wherein the camera is arranged in a vehicle. A movement of a user of the vehicle is determined by use of the camera and a processing device, wherein an interactive program is executable dependent on the movement of the user. Such an arrangement can provide signals which, for example, enable an interaction between the user and a system in the vehicle.

Abstract: A patient diabetes monitoring system with an efficient unsupervised daily monitoring profile clustering algorithm, a method, and a computer product thereof are disclosed. The system may include a physiological data input device or sensor which receives a plurality of physiological measurements to generate a dataset, a memory which stores a clustering algorithm, and a processor. The clustering algorithm when executed by the processor, causes the processor to automatically pre-process the dataset to control an amount of bias/aggressiveness from the collected unsupervised daily monitoring profiles, thereby generating a pre-processed dataset, build a similarity matrix from the pre-processed dataset, and output an optimum number of similarity clusters found by the processor from the similarity matrix.

Abstract: A method and an apparatus of providing a degree of match between biosignals are provided. A method of providing a degree of match between biosignals involves receiving biosignals corresponding to users, calculating a degree of match between the biosignals, and providing the calculated degree of match between the biosignals to one or more users.

Abstract: A computer-implemented method and a system for analyzing glucose monitoring data indicative of a glucose level, comprising: presenting by a data processing device provided a graphical window on a display device wherein the graphical window comprises a time abscissa axis that defines time units, and a glucose ordinate axis that defines glucose units; receiving a plurality of glucose monitoring values associated with a monitoring time period by the data processing device; segmenting the plurality of glucose monitoring values into a plurality of glucose monitoring traces indicative of the glucose level; defining a reference trace segment; determining the reference trace segment for each of the plurality of glucose monitoring traces; and plotting, for a time window comprising the reference trace segment, the plurality of glucose monitoring traces within the graphical window. Furthermore, a non-transitory computer readable medium is disclosed.

Abstract: Systems, methods, and computer-readable media are disclosed for identifying when a subject is likely to be affected by a medical condition. For example, at least one processor may be configured to receive information reflective of an external soft tissue image of the subject. The processor may also be configured to perform an evaluation of the external soft tissue image information and to generate evaluation result information based, at least in part, on the evaluation. The processor may also be configured to predict a likelihood that the subject is affected by the medical condition based, at least in part, on the evaluation result information.

Abstract: Systems, methods, and computer-readable media are disclosed for identifying when a subject is likely to be affected by a medical condition. For example, at least one processor may be configured to receive information reflective of an external soft tissue image of the subject. The processor may also be configured to perform an evaluation of the external soft tissue image information and to generate evaluation result information based, at least in part, on the evaluation. The processor may also be configured to predict a likelihood that the subject is affected by the medical condition based, at least in part, on the evaluation result information.

Abstract: A new computational approach may provide improved detection of disease conditions and comorbidities, such as PTSD, Parkinson's, Alzheimer's, depression, etc. For example, in an embodiment, a computer-implemented method for detecting a disease condition may comprise receiving a plurality of data streams, each data stream representing a measurement of a brain activity comprising physical and chemical phenomena and performing pattern analysis on the plurality of data streams to detect at least one fundamental code unit of a brain code corresponding to a disease condition based on a combination of the plurality of data streams.