Patents Issued in September 12, 2017
  • Patent number: 9757467
    Abstract: The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide, peptides, or both. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide and/or peptide. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: September 12, 2017
    Assignee: Transdermal Biotechnology, Inc.
    Inventor: Nicholas V. Perricone
  • Patent number: 9757468
    Abstract: This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid. Such methods are useful for treating a lysosomal storage disease through intranasal administration of a conjugate comprising one or more guanidinoglycosides and an enzyme useful for treating a lysosomal storage disease.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: September 12, 2017
    Assignee: The Regents of the University of California
    Inventors: Jeffrey D. Esko, Yitzhak Tor, Wenyong Tong
  • Patent number: 9757469
    Abstract: Polyethylene glycol modified human chorionic gonadotropin (hCG), preparations thereof, compositions thereof, and methods of preparation and use thereof are described.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: September 12, 2017
    Assignee: Ferring B.V.
    Inventors: Ian Cottingham, Daniel Plaksin, Jenny Aharanov
  • Patent number: 9757470
    Abstract: The present invention provides compositions and methods useful for delivering agents to target cells or tissues, for example nerve cells and other cells in the central nervous system. The compositions and methods are useful for delivering agents across the blood-brain barrier. The present invention also provides methods of using the compositions provided by the present invention to deliver agents, for example therapeutic agents for the treatment of neurologically related disorders.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: September 12, 2017
    Assignee: Children's Medical Center Corporation
    Inventors: Manjunath Narasimhaswamy, Premlata Shankar, Priti Kumar
  • Patent number: 9757471
    Abstract: The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such as Giardia sp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: September 12, 2017
    Assignees: UNIVERSIDAD CATOLICA DE CORDOBA, ASSISTANCE PUBLIQUE HOPITAUX DE PARIS, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECHNICAS (CONICET), UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
    Inventors: David Klatzmann, Eliane Piaggio, Hugo Lujan
  • Patent number: 9757472
    Abstract: Improved peptide compositions and synbody compositions are disclosed that show improved stability and antibiotic activity. The new antibacterial peptides for S. aureus have particular D-amino acid substitutions in order to increase protease stability while also preserving marked antibiotic activity. Thus, compositions and methods for treating infections related to S. aureus also are disclosed.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: September 12, 2017
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Chris Diehnelt, Stephen Johnston
  • Patent number: 9757473
    Abstract: A cell-penetrating peptide, a conjugate of the cell-penetrating peptide with an anticancer agent, and a composition comprising the conjugate is described. An effective means for transferring a cancer-specific anticancer agent can be provided by using the cell-penetrating peptide. More particularly, by preparing the conjugate of the present invention wherein the cell-penetrating peptide and the anticancer agent are combined, the application concentration of a conventional anticancer agent can be reduced and cancer specificity can be provided, and thus an effect of reducing side effects during the treatment process can be obtained.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: September 12, 2017
    Assignee: GemVax & KAEL Co., Ltd.
    Inventor: Sang Jae Kim
  • Patent number: 9757474
    Abstract: The present invention relates to a method for effectively delivering an anticancer drug into cancer cells by binding the anticancer drug to pH-sensitive metal nanoparticles so as to be separated from cancer cells. The pH-sensitive metal nanoparticles according to the present invention may be heated by photothermal therapy, thereby effectively killing cancer cells in conjunction with the isolated anticancer drug.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: September 12, 2017
    Assignee: Postech Academy-Industry Foundation
    Inventors: Sungjee Kim, Jutaek Nam
  • Patent number: 9757475
    Abstract: The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: September 12, 2017
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, David A. Giljohann, Weston L. Daniel, Joshua I. Cutler, Ke Zhang, Dan Zheng
  • Patent number: 9757476
    Abstract: The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: September 12, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Jeffrey M. Gross, Hai Trieu, Josee Roy, Susan J. Drapeau, Michael J. Schendel, Andrew J. Lowenthal Walsh
  • Patent number: 9757477
    Abstract: Methods and compositions for imaging Brown adipose tissue (BAT) in living mammals, e.g., humans.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: September 12, 2017
    Assignee: The General Hospital Corporation
    Inventors: Chongzhao Ran, Anna Moore, Anna-Liisa Brownell
  • Patent number: 9757478
    Abstract: A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the C-terminal portion of the thermostable luciferase to the N-terminal portion of the thermostable luciferase. The modified circularly-permuted thermostable luciferase is modified relative to a parental circularly-permuted thermostable luciferase. The linker contains a sensor region capable of interacting with a target molecule in a cell. The modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the parental circularly-permuted thermostable luciferase in the presence of the target molecule. Alternatively, the modified circularly-permuted thermostable luciferase has an enhanced response after interaction of the biosensor with the target molecule relative to the modified circularly-permuted thermostable luciferase in the absence of the target molecule.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: September 12, 2017
    Assignee: Promega Corporation
    Inventors: Brock Binkowski, Braeden Butler, Lance P. Encell, Frank Fan, Brad Hook, Paul Otto, Gediminas Vidugiris, Susan Wigdal, Kristopher Zimmerman
  • Patent number: 9757480
    Abstract: A radiopaque particulate material one or more of SiO2, TiO2, La2O3, Na2O and MgO and useful for embolization which optionally includes therapeutic components that are released in vivo.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: September 12, 2017
    Assignee: ABK Biomedical Incorporated
    Inventors: Robert J. Abraham, Sharon Kehoe, Daniel Boyd
  • Patent number: 9757481
    Abstract: UV-Laser-synthesized, fluorescent, spherical and magnetic nanoparticles are loaded Sophorolipid mesostructures useful for bio-imaging and therapeutic applications.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: September 12, 2017
    Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Asmita Ashutosh Prabhune, Pradeep Kumar Singh, Ruchira Arup Mukherji, Satishchandra Balkrishna Ogale
  • Patent number: 9757482
    Abstract: Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanoparticles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. 5?100*D?(IO)/C?(IO)??[Relation 1] 2.5?100*D?(Cap)/C?(Cap)??[Relation 2] 0.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: September 12, 2017
    Assignee: HANWHA CHEMICAL CORPORATION
    Inventors: Bong-Sik Jeon, Eung Gyu Kim, Eun Byul Kwon, Ju Young Park, Wan Jae Myeong
  • Patent number: 9757483
    Abstract: A diagnostic formulation is provided comprising a tropane having a radioactive concentration of at least 1.6 mCi/mL at least about 51 hours post creation. The diagnostic formulation optionally comprises a radiolabeled dopamine transporter (DAT) ligand useful in the diagnosis of Parkinson's disease (PS). One example of a radiolabeled dopamine transporter (DAT) ligand example is [123I]-2?-carbomethoxy-3?-(4-flurophenyl)-N-(3-iodo-E-allyl) nortropane.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: September 12, 2017
    Assignee: Alseres Pharmaceuticals, Inc.
    Inventors: Chris Sterzinger, Cara Ferreira, David Leyh, Richard Thorn
  • Patent number: 9757484
    Abstract: Disclosed herein are methods of making sterilized ciprofloxacin compositions. In some embodiments, the method includes the steps of: (a) forming an aqueous suspension comprising ciprofloxacin particles; (b) heating the aqueous suspension comprising ciprofloxacin particles at a temperature range of from about 100° C. to about 120° C.; and (c) allowing the aqueous suspension comprising ciprofloxacin particles to cool down. Also described herein are otic formulations containing ciprofloxacin formed by the disclosed methods, and therapeutic use of such otic formulation for providing sustained release of ciprofloxacin into the ear for treating various otic disorders and conditions.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: September 12, 2017
    Assignee: OTONOMY, INC.
    Inventors: Scott H. Coleman, Wei-Cheng Liaw, Jerry Wroblewski, Robert Savel
  • Patent number: 9757485
    Abstract: A system and method of fluid sterilization is provided, which incorporates a heating section to heat pressurized fluid above prescribed thresholds for temperature, pressure, and duration (e.g., dwell time) to achieve desired levels of sterilization, including a heat exchanger to both (a) preheat fluid prior to entering the heating section and (b) cool outflow of the heating apparatus, in which fluid travels through the apparatus by operating valves forward and aft of the heating section in a controlled sequence to facilitate flow through the system while maintaining prescribed pressure and temperature profiles. The system operates within prescribed ranges of pressure and temperature to achieve the desired level of sterilization without need of maintaining a fixed temperature or a fixed pressure within any portion of the system, including the heating section.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: September 12, 2017
    Inventor: Michael Papadopoulos
  • Patent number: 9757486
    Abstract: A solution for cleaning and/or sterilizing one or more surfaces in a bathroom is provided. The sterilization can be performed using ultraviolet sources, which can emit ultraviolet radiation directed onto the surface(s). The cleaning can be performed using a fluid, such as water, that is flowed over the surface(s). The surface(s) can include at least a seat of a toilet and/or other surfaces associated with the toilet.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: September 12, 2017
    Assignee: SENSOR ELECTRONIC TECHNOLOGY, INC.
    Inventors: Alexander Dobrinsky, Michael Shur, Remigijus Gaska
  • Patent number: 9757487
    Abstract: Embodiments of the invention relate to a method and apparatus for self-sterilizing a surface or other portion of the apparatus and/or sterilizing other objects. Embodiments can utilize self-generated and/or remotely controlled plasma fields for the purpose of self-sterilization and/or sterilization of another object. Embodiments of the invention can have broad applications in procedures and equipment requiring the sterility of devices used for medical procedures, decontamination procedures, drug delivery, sterility of consumer products, and sterility of food preparation equipment and tools.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: September 12, 2017
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Subrata Roy, Karl Zawoy
  • Patent number: 9757488
    Abstract: The present invention relates to a method and device for sterilizing parisons made of a thermoplastic material that are intended for producing blow-molded containers. During the sterilizing process a sterilizing agent is introduced into an interior of the parison by an applicator. At least one gas is supplied to the applicator via at least one supply element, at least sections of which are arranged in a horizontal direction next to a transport path of the applicator. The supply element comprises at least one outlet opening facing towards the applicator. At least one pressure-applying element is arranged between the applicator and the supply element and is resiliently clamped between the applicator and the supply element.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: September 12, 2017
    Assignee: KHS Corpoplast GmbH
    Inventors: Thomas Herold, Harald Rieger, Dieter Klatt, Martin Gerhards
  • Patent number: 9757489
    Abstract: A modular component container system includes a plurality of case walls and a plurality of connectors. Each of the connectors includes at least two connector elements that mechanically connect to the case walls. The system also includes at least one latch connector having a latch connector element. The latch connector element mechanically connects to one of the case walls. A latch is movably oriented relative to the latch connector element. The latch releasably engages another of the case walls.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: September 12, 2017
    Assignee: Symmetry Medical Manufacturing, Inc.
    Inventor: Kraig Herman Allen
  • Patent number: 9757490
    Abstract: A membrane device is intended for the release of volatile compositions. The membrane device includes one or more membrane layers which are permeable to the volatile composition and which are positioned within a vapor impermeable package such as package formed by an upper and lower vapor impermeable panel. The upper vapor impermeable panel includes a window that allows access to the membrane layer for activation of the membrane device. The membrane device can also include decorative portions for aesthetic appeal.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: September 12, 2017
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Thomas F. Santini, Anthony R. Budraitis
  • Patent number: 9757491
    Abstract: An absorbent structure comprising absorbent polymer particles supported by a substrate layer and immobilized on this substrate layer by a thermoplastic adhesive material and further comprising a component sorbing oily substances that may migrate from the thermoplastic adhesive material is disclosed. The absorbent structure can be suitably incorporated in a disposable absorbent article.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: September 12, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Robin Lynn McKiernan, Axel Meyer, Gabriele Stiehl, Carolyn Ann Spitzmueller
  • Patent number: 9757492
    Abstract: The present invention relates to a process for producing a hydroxy amino polymer comprising the steps: a) Reaction of an H functional starter compound bearing at least one Zerewitinoff active H atom with an unsaturated, cyclical carboxylic acid anhydride and at least one alkylene oxide compound for obtaining a prepolymer bearing hydroxyl groups, b) Addition of a primary amine and/or of ammonia to the double bond(s) of the prepolymer bearing hydroxyl groups obtained according to step a) for obtaining the hydroxy amino polymer, wherein the ratio of added amino groups to hydroxyl groups in a hydroxy amino polymer is at least 0.6. Furthermore, the invention relates to a hydroxy amino polymer, which can be achieved according to this process as well as a polyurea/polyurethane system, which contains such a hydroxy amino polymer.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: September 12, 2017
    Assignee: Adhesys Medical GmbH
    Inventors: Heike Heckroth, Christoph Eggert, Jörg Hofmann, Klaus Lorenz, Edward Browne, Hartmut Nefzger
  • Patent number: 9757493
    Abstract: Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. The first component comprises a polymerizable resin comprising ethylenic unsaturated double bond, a suitable glycidyl group and/or a suitable isocyanate group. The second component includes a compound comprising more than one type of amine selected from the group consisting of primary amine, secondary amines, tertiary amines and quaternary amines. Alternatively, the second component includes a compound comprising a suitable mercapto (SH—) group, a hindered amine or a dimethylthiotoluenediamine (DMTDA). Optionally, the cement product includes a filler and/or a bioactive component to promote bone formation.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: September 12, 2017
    Assignee: Pioneer Surgical Technology, Inc.
    Inventors: Juchui Ray Lin, Edward S. Ahn, Brian M. Schlossberg
  • Patent number: 9757494
    Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 12, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Bordeaux II Victor Segalen, Universite Paris Diderot-Paris 7
    Inventors: Joelle Amedee, Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui, Jean-Christophe Fricain, Sylvain Catros
  • Patent number: 9757495
    Abstract: Methods for preparing and using collagen extracts and collagen scaffolds are provided. Additionally methods and related kits for the repair of articular tissue using the collagen material are provided.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: September 12, 2017
    Assignee: Children's Medical Center Corporation
    Inventor: Martha M. Murray
  • Patent number: 9757496
    Abstract: An electro-conductive hydrogel composite material that may be suitable as an artificial skin satisfies all four requirements of artificial skin, namely, flexibility, electrical conductivity, healing property, and biocompatibility. The electro-conductive hydrogel composite material includes a hydrogel composition including water and a cross-linkable polymer which reversibly forms cross-linkage by hydrogen bonding; and an electro-conductive material dispersed in the hydrogen bond-based hydrogel.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: September 12, 2017
    Assignees: SAMSUNG ELECTRONICS CO., LTD., KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jae-hyun Hur, No-kyoung Park, Kyu-hyun Im, Sang-won Kim, Sung-woo Hwang, Jang-wook Choi
  • Patent number: 9757497
    Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: September 12, 2017
    Assignee: Surmodics, Inc.
    Inventor: Joram Slager
  • Patent number: 9757498
    Abstract: A method for manufacturing an alumina-based layer structure having transition regions between layers is disclosed. The method may include ion milling a stainless steel structure surface to partially reduce a metal oxide layer from, and create an exposed portion of, the surface. The method may include oxidizing the exposed portion of the surface to form a crystallized metal oxide bonding layer, growing a crystallized alumina layer onto the metal oxide bonding layer, and diffusing metal from the surface into the crystallized alumina layer, to form a graded aluminate spinel layer. The method may include forming a first transition region from the graded aluminate spinel layer to a crystalline alumina layer, growing the crystalline alumina layer from the first transition region, forming a second transition region from the crystalline alumina layer to an amorphous alumina layer, and growing the amorphous alumina layer from the second transition region.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: September 12, 2017
    Assignee: International Business Machines Corporation
    Inventors: Robert G. Biskeborn, Calvin S. Lo, Philip M. Rice, Teya Topuria
  • Patent number: 9757499
    Abstract: Biofunctional films and methods of use thereof for the prevention of post-operative adhesions are disclosed.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: September 12, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Noshir Langrana, Devendra Verma, Michelle Previtera
  • Patent number: 9757500
    Abstract: Systems and methods for delivery of fluid to a wound therapy dressing. In exemplary embodiments, a pressure sensor measures the pressure at the wound therapy dressing and restricts fluid flow to the wound therapy dressing when a predetermined pressure is achieve.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: September 12, 2017
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Kevin W. Bendele, James A. Luckemeyer
  • Patent number: 9757501
    Abstract: Apparatus and methods are provided for applying negative pressure to tissues of a patient that are transmitted to the vertebral venous system of the patient and thereby lowering intracranial pressure. Intracranial pressure is thus lowered easily without increasing the work of breathing, without needing to be intubated, and without breathing through a valve in patients with elevated increased intracranial pressure.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: September 12, 2017
    Assignee: Board of Regents, The University of Texas System
    Inventors: Thomas Jennings, David B Gillis
  • Patent number: 9757502
    Abstract: In one general aspect, a method includes measuring blood flow through a right rotary blood pump, measuring blood flow through a left rotary blood pump, and controlling a speed of one of the rotary blood pumps using a controller that calculates the speed of one of the rotary blood pumps based on the measured blood flow through the other rotary blood pump.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 12, 2017
    Assignee: TCI LLC
    Inventors: David J. Burke, Kevin Bourque
  • Patent number: 9757503
    Abstract: A device and method for monitoring the connection of a blood treatment unit to a fluid system of an extracorporeal blood treatment apparatus are described, in which the blood treatment unit includes an inlet and an outlet for connection to the fluid system and the fluid system includes a line system with a first line segment connected to the inlet and a second line segment connected to the outlet. An extracorporeal blood treatment apparatus includes a device for monitoring the connection of the blood treatment unit to the fluid system. The device and method for monitoring the connection of the blood treatment unit to the fluid system is based on measurement of pressure in the fluid system of the blood treatment apparatus. Solely on the basis of the pressure measurement, it is ascertained whether the connection of the blood treatment unit to the fluid system is correct or incorrect.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: September 12, 2017
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Juergen Haecker, Soeren Gronau
  • Patent number: 9757504
    Abstract: Systems and methods for performing hemodialysis to remove metabolic waste from the blood of a patient are disclosed. The systems and methods preferably comprise at least one blood processing apparatus that receives whole blood from a patient. Cellular blood components are removed from the whole blood by hemofiltration, to provide filtered plasma comprising metabolic waste that is substantially reduced of blood cells. The cellular blood components may be returned to the patient. The filtered plasma comprising waste may be removed from the blood processing apparatus through a waste path for further processing in a separate apparatus, or in the same apparatus in a second stage processing procedure to remove metabolic waste components and excess water from the plasma by hemodialysis. At least one of the hemofiltration and hemodialysis processing apparatus comprises a Taylor vortex-enhanced separation apparatus.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: September 12, 2017
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SA
    Inventors: Randolph H. Watkins, Steven J. Wurgler, Shincy Maliekkal, Sujatha Karoor, Katrina Smith
  • Patent number: 9757505
    Abstract: A pressure output device (POD) assembly for sensing fluid pressure in a fluid processing system, is provided. This POD assembly includes a shell defining a shell interior, and a movable diaphragm disposed in the shell interior and separating the shell interior into a flow-through chamber and a pressure sensing side. A sensor port is in fluid communication with the pressure sensing side. An inlet port and an outlet port are in fluid communication with the flow-through chamber. The inlet port and the outlet port define an inlet and an outlet, respectively, of a flow-through channel that passes through the flow-through chamber. A boss protrudes from the interior wall of the shell and extends into the flow-through channel to prevent occlusion of flow under different pressure conditions within the flow-through chamber.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: September 12, 2017
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: DeLoy Lindley, Jose Antonio Badillo, Michael Parry Smith, Richard Allen Lasher, Troy Calvin Dayton, Lynn E. Jensen
  • Patent number: 9757506
    Abstract: An integrated kit for separating blood and concentrating PRP includes: (a) a main body that includes an upper storage portion, a lower storage portion, and a passage portion for connecting the upper storage portion and the lower storage portion; (b) a upper cover coupled to an upper end of the upper storage portion; (c) an inner stopper inserted into a lower end of the lower storage portion so as to seal the lower storage portion; (d) a closing adjustment screw which can move vertically while penetrating a hole formed at the inner stopper and seals the passage portion; and (e) a lower cover coupled to an outside of the lower end of the lower storage portion and the outside of the inner stopper to prevent the separation of the closing adjustment screw coupled to the inner stopper in case of centrifugation.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: September 12, 2017
    Assignee: Rmedica Co., Ltd.
    Inventors: Jeong Chan Ra, Jae Wook Huh
  • Patent number: 9757507
    Abstract: An operating room control system that is soft configurable allowing a user to completely configure the control and function of the system. The system includes a touchscreen that provides a video display received from a video endoscope and presents icons on the touchscreen allowing the user to control and interface with the tools/equipment in the operating room as well as hospital systems. The controls, displays, tools, equipment, etc. are configured to be operated from a single centralized platform.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: September 12, 2017
    Assignee: Karl Storz Imaging, Inc.
    Inventors: Lee D. Holoien, Hans-Uwe Hilzinger, Christoph Hiltl
  • Patent number: 9757508
    Abstract: A system for controlled delivery of medical fluids to a patient includes an inlet conduit attached to a source of a medical fluid and an outlet conduit connected to the patient. The inlet and outlet conduits are interconnected by a multiple stage control valve assembly and a pair of syringes. The control valve assembly is alternated between a first state wherein the inlet conduit communicates with a first syringe for transmitting fluid from the source to the first syringe, a second state wherein the first syringe communicates with a second syringe and is isolated from the inlet conduit and the outlet for transmitting fluid from the first syringe to the second syringe, and a third state wherein the second syringe communicates with the outlet and is isolated from the inlet and the first syringe for transmitting fluid from the second syringe to the patient through the outlet.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: September 12, 2017
    Inventors: Kimberley Levy, Frank Levy
  • Patent number: 9757509
    Abstract: A method and apparatus for controlling IV medication delivery and monitoring, the method including providing information tags on IV bags that specify delivery parameters, obtaining delivery parameters for at least one bag, associating a controller with a particular patient, comparing patient information for the particular patient with the delivery parameters, determining the efficacy of delivering the medicant to the patient and affecting pump control as a function of the comparison. The method also includes various timing rules and other verification procedures.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: September 12, 2017
    Assignee: B. BRAUN MEDICAL INC.
    Inventor: Carlos A. De La Huerga
  • Patent number: 9757510
    Abstract: Described and illustrated is a diabetes management system that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The glucose sensor is configured to sense glucose levels in the subject and provide output signals representative of the glucose levels in the subject. The controller is programmed to receive signals from at least one of the glucose sensor and the pump and configured to issue signals to the pump to deliver an amount of insulin determined by a feedback controller that utilizes a model predictive control and also configured to deliver at least the basal amount of insulin whenever the subject has initiated a manual bolus of insulin and a sensed or measured glucose level is at least a first threshold within a first duration of time.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: September 12, 2017
    Assignee: Animas Corporation
    Inventor: Daniel Finan
  • Patent number: 9757511
    Abstract: A personal medical device and method of use with restricted mode challenge having a personal medical device including: a memory operable to store programming code; a processor operably connected to the memory; a user input having input buttons to receive input from the user; and a user display to display output to the user. The processor is operable to: detect a user request for entry to the restricted mode; display a user input image on the user display, the user input image including display buttons corresponding to the input buttons; highlight one of the display buttons; detect actuation of one of the input buttons on the user input; and deny entry to the restricted mode when the one of the input buttons does not correspond to the highlighted display button.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: September 12, 2017
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Robert G. Adamczyk, Mark Freger, David P. Lewinski, Ulrich H. Rankers, Lisa M. Val Verde, Steven J. Vargas, Yongbo Wang
  • Patent number: 9757512
    Abstract: A disposable, wearable, self-contained insulin dispensing device includes a housing and an insulin source in the housing that is connected to a catheter for injecting insulin into a user.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: September 12, 2017
    Assignee: Bigfoot Biomedical, Inc.
    Inventors: Morten Mernoe, Michael Gorm Lyngsie
  • Patent number: 9757513
    Abstract: Provided is a cassette unit suitable for use with an auto-injector having an electrically powered drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity and a needle projection aperture. The housing cavity may receive a syringe. Axially movable within the barrel of the syringe for forward movement into contact with the syringe plunger, there is a plunger slaving part defining a circumferential wall arranged for frictional sliding relationship with the inner wall of the barrel, a rear drive-receiving face and a front plunger-contacting face. The plunger slaving part is arranged such that when a drive load is applied to its rear drive-receiving face to bring the front plunger-contacting face into contact with the plunger the drive load is evenly transmitted. The circumferential wall is provided with slide restrictors that restrict frictional sliding movement thereof in relation to the inner wall of the barrel.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: September 12, 2017
    Assignee: UCB Biopharma SPRL
    Inventors: Martin John McLoughlin, Michael James David Heald, Ilario Melzi, Stefan Verlaak, Tatiana Palombi
  • Patent number: 9757514
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to a delivery mechanism having one or more balloons or other expandable devices which are expandable responsive to a condition in the small intestine or other GI lumen to advance the preparation out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: September 12, 2017
    Assignee: Rani Therapeutics, LLC
    Inventors: Mir A. Imran, Peter Herrmann, Baber Syed, Timothy H. Williams, Chang Jin Ong, Greg Method
  • Patent number: 9757515
    Abstract: A manual infusion set comprises a top connector lockable in a plurality of positions. The top connector and tubing is initially loaded from the top and then slid forward in order to puncture the septum. Once the connector is attached, it cannot be rotated. With the connector locked in place, flexible tubing connects the septum hub with a medicine pump, which continually supplies medicine such as insulin to a user.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: September 12, 2017
    Assignee: Flextronics AP, LLC
    Inventor: Lopa Rishi Patel
  • Patent number: 9757516
    Abstract: A medical device and a system for medical treatment comprising the medical device are disclosed. The medical device comprises a fluidic conduit and/or is configured to be operatively coupled to a fluidic conduit. The medical device comprises a flow regulator for regulating the flow of a fluid in the fluidic conduit and at least two movable elements, which are passively displaceable as a function of a fluidic pressure change in the fluidic conduit or actively displaceable for regulating the flow of fluid in the fluidic conduit. The medical device further comprises at least one transponder circuit comprising at least one transponder element chosen from a capacitor, an inductor, a resistor, or combinations thereof, being arranged with respect to the movable elements such that the transponder circuit has a capacitance or inductance or resistance or resonant frequency or Q factor, which changes as a function of the displacement of the movable elements.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: September 12, 2017
    Assignee: MEDIRIO S.A.
    Inventor: Irio Giuseppe Calasso
  • Patent number: 9757517
    Abstract: A piston pump is described for pumping a fluid. The pump includes at least one cylinder having a piston movable inside the cylinder along the longitudinal axis of the cylinder by a drive, each cylinder having at an end face a mounting flange having at least one cylinder opening, and a chamber having a volume that changes when the associated piston is moved in the cylinder. The piston pump has an inlet port for supplying and an outlet port for draining the fluid. A rotatable valve plate is arranged on the other side of the mounting flange. The mounting flange has at least one passage in the region of the inlet port and the outlet port, respectively, through which the fluid can flow between the inlet port and/or the outlet port and the other side of the mounting flange. The valve plate has fluid-transporting means by which, upon rotation of the valve plate at least one cylinder opening can be connected to a passage of the inlet and/or the outlet port.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: September 12, 2017
    Assignee: B. Braun Melsungen AG
    Inventor: Dietmar Eberhard