Abstract: Provided are a blood pressure estimation apparatus, a sphygmomanometer, a blood pressure estimation system, and a blood pressure estimation method which allow continuous blood pressure measurement without adding stress to a subject's body. A plurality of sensors and a controller are included. The plurality of sensors each detect a pulse wave of a subject without applying, to the subject, pressure that is greater than predetermined pressure, and the controller calculates an estimated value of subject's blood pressure continuously, based on a measured value of the subject's blood pressure acquired from a sphygmomanometer and on output of the sensors.

Abstract: A blood pressure measurement device comprises a case, a first electrode and a stress sensor. The case includes a first surface and a second surface. The first electrode is disposed on the first surface, and the stress sensor is disposed on the second surface. The blood pressure measurement device is operated on a part of a body of a user. The part of the body has a blood vessel inside. Upon measurement of the blood pressure, the first electrode, the stress sensor and the blood vessel at least partially overlap in one projection orientation. Therefore, the stress sensor is able to be pressed on the part of the body when the user touches the first electrode. A method of blood pressure measurement is also disclosed.

Abstract: Methods and systems are described for detecting the likelihood of patent ductus arteriosus (PDA) in an infant using electrocardiogram and photoplethysmographic pulse signals obtained from the upper body and foot of the infant.

Abstract: A pulse wave analyzing apparatus comprises an acquiring section (11) which acquires a pulse wave that is non-invasively measured, and an analyzer (12) which calculates data on the frequency axis by using the pulse wave, and which obtains the index value of the respiratory-induced variation based on the calculated data on the frequency axis.

Abstract: Wireless intracranial monitors are provided. The wireless intracranial monitors comprise a main body, a wireless transceiver, a processing module, and a sensing module, in which the sensing module contains a catheter. On the catheter, a pressure sensor is configured to detect deformation of the catheter or a diaphragm connected to the pressure sensor. The detected deformation is then transmitted to the processing module through an in-catheter wire.

Abstract: Methods, apparatuses and wearable devices for measuring an ECG signal for a user wearing a wearable device includes when the ECG signal is measured in a first mode, receiving the ECG signal by an ECG sensor from a closed circuit formed by a first ECG sensor electrode and a second ECG sensor electrode, in which the wearable device includes a main body detachable to the wearable device, a connecting portion, and electrode patches, and the main body includes the ECG sensor, the first ECG sensor electrode, and the second ECG sensor electrode, and when the ECG signal is measured in a second mode, receiving the ECG signal by the ECG sensor from a closed circuit formed by electrodes of the electrode patches, in which the ECG sensor is in the main body and the main body is connected to the electrode patches.

Abstract: A method for processing EEG signals includes reading the EEG signals from two frontal electrodes of an electroencephalograph (301); converting the EEG signals to a frequency domain (305); determining values of a BIS/BAS response on the basis of an asymmetry between the EEG signals (208). The method includes calculating the asymmetry between the EEG signals in the frequency domain in a frequency range from 26 to 29 Hz.

Abstract: Disclosed herein is a framework for facilitating patient signal analysis based on vector analysis. In accordance with one aspect, a set of vectors is generated from a patient signal data waveform. The vectors may be directed from a common center to points of interest on the patient signal data waveform. The framework may further extract one or more vector parameters from the set of vectors, and determine one or more vector ratios based on the vector parameters to monitor changes in the patient signal data waveform.

Abstract: Disclosed herein is a framework for facilitating patient signal analysis based on vector analysis. In accordance with one aspect, a set of vectors is generated from a patient signal data waveform. The vectors may be directed from a common center to points of interest on the patient signal data waveform. The framework may further extract one or more vector parameters from the set of vectors, and determine one or more vector ratios based on the vector parameters to monitor changes in the patient signal data waveform.

Abstract: A system and method for non-invasively generating a report of cardiac electrical activities of a subject includes determining, using cardiac electrical activation information, equivalent current densities (ECDs). The ECDs are assembled into time-course ECD information and a spectrum of the time-course ECD information is analyzed to determine peaks for spectral characteristics of atrial fibrillation (AF). The spectral characteristics of AF are correlated with potential electrical sources of the AF and a report is generated indicating the potential electrical sources of the AF spatially registered with the medical imaging data.

Abstract: A system and method for detecting and verifying bradycardia/asystole episodes includes sensing an electrogram (EGM) signal. The EGM signal is compared to a primary threshold to sense events in the EGM signal, and at least one of a bradycardia or an asystole is detected based on the comparison. In response to detecting at least one of a bradycardia or an asystole, the EGM signal is compared to a secondary threshold to sense events under-sensed by the primary threshold. The validity of the bradycardia or the asystole is determined based on the detected under-sensed events.

Abstract: Non-invasive “drawable”, or “paintable”, electrode for electrical stimulation or biological signal sensing comprising a pervious and electrically conductive layer (1), at least one electrically insulating element (2) for maintaining the electrically conductive layer (1) separated from the skin (11), and a conductive material (3) that is deposed using a delivery system (4) on desired areas (5) of the electrically conductive layer (1). The conductive material (3) can penetrate the electrically conductive layer (1) and any other part of the electrode underlying the desired areas (5), thus reaching the skin. The conductive material (3) creates an electrical connection between the desired areas (5) of the electrically conductive layer (1) and the skin. Therefore, the shape of the desired areas (5) electrically connected with the skin, can be customized by the user deposing (or “drawing”) the conductive material (3).

Abstract: A multielectrode sensor for use in obtaining electrocardiograph measurements of a patient is disclosed. The sensor includes a substrate, at least a portion of the substrate being stretchable, and a plurality of electrodes coupled to the substrate. A distance between at least two of the electrodes is adjustable by stretching the substrate between the at least two electrodes.

Abstract: An evoked potential monitoring system including a control unit having stimulator circuitry and a probe assembly coupled to the control unit. The probe assembly includes a stimulus probe and a stimulator handpiece selectively coupled to the stimulus probe. The handpiece includes a handle, control circuitry, and a switch. The control circuitry is electrically coupled to the stimulator circuitry. The switch is electrically coupled to the control circuitry and extends to an exterior portion of the handle. In this regard, movement of the switch remotely controls the stimulator circuitry to continuously increment or decrement a stimulation energy level delivered to the stimulus probe over a series of discrete, incremental steps.

Abstract: A method of visualizing spinal nerves includes receiving a 3D image volume depicting a spinal cord and a plurality of spinal nerves. For each spinal nerve, a 2D spinal nerve image is generated by defining a surface within the 3D volume comprising the spinal nerve. The surface is curved such that it passes through the spinal cord while encompassing the spinal nerve. Then, the 2D spinal nerve images are generated based on voxels on the surface included in the 3D volume. A visualization of the 2D spinal images is presented in a graphical user interface that allows each 2D spinal image to be viewed simultaneously.

Abstract: A system and method of suppressing stimulation artifacts when performing electrophysiological electrical stimulation and recording. An artifact waveform is captured associated with a stimulus output, and then the artifact waveform calibrated during another stimulus output for accurately representing the actual artifact waveform received within each measured response to a stimulus. During actual stimulus generation and response recording, the calibrated artifact waveform is subtracted in at least one of the amplifier stages so that the artifacts are removed from the amplified response to the stimulus thus providing an accurate output without saturating the amplifiers.

Abstract: An optical tracking system may comprise a reference marker unit stationarily disposed relative to a patient, a shape measurement unit configured to measure the three-dimensional shape of a specified part of the patient corresponding to a three-dimensional image, a tracking sensor unit configured to sense the reference marker unit and the shape measurement unit, and a processing unit. The processing unit may acquire a coordinate transformation relationship between the reference marker unit and the tracking sensor unit and a coordinate transformation relationship between the shape measurement unit and the tracking sensor unit based on a sensing result of the tracking sensor unit, acquire a coordinate transformation relationship between the specified part of the patient and the shape measurement unit based on a measurement result of the shape measurement unit, and define a coordinate system of the patient relative to the reference marker unit from the acquired coordinate transformation relationships.

Abstract: The present invention provides a method for monitoring swallowing in a subject, comprising: (a) providing a food product comprising a volatile compound to the subject; and (b) detecting release of the volatile compound in exhaled breath during and/or after swallowing of the food product.

Abstract: Disclosed herein are spirometers that can be used for assessment of pulmonary lung function. The disclosed systems, computer readable mediums and methods can be directed towards use in a variety of settings by health care professionals, clinical trial specialists, and individual users.

Abstract: According to an aspect, a testing instrument that is used for testing an airway protection function includes: a pipe portion continuous from an inlet port to an outlet port, the pipe portion having a plurality of holes penetrating the pipe portion from an outer surface of the pipe portion to an inner surface of the pipe portion, the holes being provided for guiding a reagent gas mixture to the inside of the pipe portion; and a guide portion covering all of the holes to form a closed space and guiding the reagent gas mixture to the closed space from an inflow port.

Abstract: Disclosed is a first force sensing region of footwear. The first force sensing region includes a first force sensor unit. The first force sensor unit includes a first compliant capacitor disposed with respect to a first plane. The first force sensor unit also includes a strain transformation structure disposed with respect to the first plane. The strain transformation structure includes a first transformation element coupled to an outer surface of the first electrode of the first compliant capacitor and a second transformation element coupled to an outer surface of the second electrode of the first compliant capacitor.

Abstract: System and method for monitoring motor recovery in a post-stroke treatment is disclosed. Motor activity data corresponding to limbs movement is collected during an acute stroke period. The motor activity data is transmitted to at least one base station and an activity value for each arm of two arms is calculated in a predefined time window by using the motor activity data. The activity value for each arm is compared thus providing the monitoring of the motor activity.

Abstract: A system and method for addressing patient health through monitoring patient movement that includes, during a treatment stage, collecting kinematic data from at least one inertial measurement unit of an activity monitoring system; generating a set of biomechanical signals from the kinematic data wherein the set of biomechanical signals characterize at least one biomechanical property; updating a mobility quality score of the subject based on the set of biomechanical signals; and delivering a health assessment.

Abstract: A hearing test system comprising: a computer system comprising a visual display for a user to select out of a plurality of sound types a desired sound type of a test sound for transmission to a subject and to select out of a plurality of computer-based input events a desired computer-based input event for registering a subject response to said test sound.

Abstract: In some embodiments, an electrochemical sensing system includes a working electrode and a reference electrode. At least a portion of the working electrode includes rhodium. An electrical circuit is electronically coupled to the working electrode and the reference electrode. The electrical circuit is configured to bias the working electrode at voltage of less than about 0.4 V which is sufficient to electrochemically decompose a target analyte, and to measure a current corresponding to the concentration of the target analyte. In some embodiments, a biosensing molecule can be disposed on the working electrode and is operative to catalytically decompose a non-electroactive target analyte to yield and an electroactive by-product. In some embodiment, the reference electrode can include rhodium and its oxides.

Abstract: An electrochemical sensor system is adapted to assist in determining an analyte concentration of a fluid. The electrochemical sensor system comprises a substrate, conductive material and a hydrogel or liquid. The substrate having porosity therethrough. The conductive material includes at least one electrode. The at least one electrode is coupled to the substrate. The at least one electrode has a first surface and an opposing second surface. The hydrogel or liquid is adapted to assist in carrying the analyte of the fluid to the first and second surfaces of the at least one electrode.

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Abstract: Systems and methods for applying time-dependent algorithmic compensation functions to data output from a continuous analyte sensor. Some embodiments determine a time since sensor implantation and/or whether a newly initialized sensor has been used previously.

Abstract: A method, system, and device for improving the accuracy of a continuous glucose monitoring sensor by estimating a CGM signal at a time t+PH using a value of CGM at time t, using a real-time short-time glucose prediction horizon to estimate the real time denoised CGM value with a noise estimation algorithm.

Abstract: An ion-sensitive sensor includes a dielectric layer comprising Al2O3 having a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic solution containing a concentration of alkali ions. An electrode is arranged to apply an electric potential to the functionalized surface of the ion-sensitive sensor. In some embodiments the ion-sensitive sensor is an ion-sensitive silicon FET. In some embodiments the ion-sensitive sensor is an ion-sensitive polymer FET. In some embodiments, the electrode comprises a perforated gate metal layer disposed on the gate dielectric layer of an ion-sensitive FET, and the functionalized surface is disposed in openings of the perforated gate metal layer. In some embodiments the dielectric layer comprises a multi-layer dielectric stack including at least one Al2O3 layer. In some embodiments the dielectric layer is deposited by atomic layer deposition (ALD).

Abstract: A method and apparatus for assessing tissue oxygenation saturation during physical activity comprising the steps of providing at least one near-infrared spectroscopy probe including at least one near-infrared light source and at least one photodetector-and measuring oxygen saturation in at least one of a skin dermis layer, an adipose layer and a muscular fascial layer of a user.

Abstract: An electrochemical sensing system includes a working electrode and a reference electrode, which can at least partially be disposed in a housing. At least a portion of the working electrode includes rhodium metal. An electrical circuit is disposed in the housing and configured to be electronically coupled to the electrodes. The electrical circuit is operative to: (a) bias the working electrode at a voltage of less than about 0.4 V, and (b) measure a current corresponding to the concentration of the target analyte. A communications module is electrically coupled to the electrical circuit and configured to display a concentration of the target analyte, and/or communicate data between the electrical circuit and an external device. The electrodes are movable between a first configuration in which the electrodes are substantially disposed inside the housing, and a second configuration in which at least a portion of the electrodes is disposed outside the housing.

Abstract: Systems and methods for discovery and characterization of neuroactive drugs are provided. In some aspects, a method for evaluating an effectiveness of a drug administered to a subject includes receiving neurophysiological data acquired from a subject under an administration of a drug, and analyzing the neurophysiological data to generate signatures indicative of brain states induced by the drug. The method also includes correlating the generated signatures with a database comprising information associated with a plurality of drug profiles, and determining, using the information, a molecular activity profile for the drug. The method further includes generating a report indicative of the effectiveness of the drug using the molecular activity profile.

Abstract: A mobile terminal and a control method therefor are disclosed. An embodiment of the present invention comprises: a detection unit for monitoring a stress index on the basis of a user's biometric information and detecting a first interval where the rate of change at which an increased stress index decreases exceeds a reference range; a storage unit for storing context information corresponding to the detected first interval; and a control unit for, when a second interval where the rate of change at which the increased stress index decreases is less than the reference range occurs, generating stress relief information using the stored context information and outputting the generated stress relief information.

Abstract: A wearable dental apparatus for capturing dental properties of a patient includes a support structure. The support structure is configured to be worn on the dentition of the patient. The wearable dental apparatus includes at least one sensor. The sensor is coupled to the support structure. The sensor is configured to capture a series of measurement of a dental property of the patient. The measurements are associated with one or more locations on the dentition of the patient. A dental map is generated based on at least some of the measurements and is displayed. The dentition of a patient is restored by selecting a restoration material based on the measurements.

Abstract: Diagnostic systems and methods for measuring and assessing spine instability are described which involve reconstruction of a dynamic three-dimensional model of a patient's spine moving through a range of motions, and optimization of the three-dimensional model to provide relative three-dimensional position and orientation data for each vertebra in the spine throughout the motion. Vertebral movement is thereby accurately measured and instability determined for presentation in a user-friendly form.

Abstract: A device is provided for use by a user, wherein the device includes a first sensor, a second sensor and an efficiency generating component. The first sensor detects a first parameter and generates a first detected signal based on the first detected parameter. The second sensor detects a second parameter and generates a second detected signal based on the second detected parameter. The efficiency generating component generates an efficiency signal based on the first detected signal and the second detected signal.

Abstract: The present invention provides a system for guiding correction of walking gait and a control method thereof, which can make a user have fun in correction of walking gait so as to enhance a walking correction guiding effect. The control method of the system for guiding correction of walking gait includes the steps of: acquiring reference gait state information on the basis of user information; acquiring current gait state information on the basis of a gait signal received from a gait detecting device; composing a monitoring screen showing a comparison result between the reference gait state information and the current gait state information; and outputting the monitoring screen.

Abstract: A device of the disclosure determines to which of a plurality of sleep stages in a sleep state including a wake stage a sleep state of a subject belongs, based on a sleep state function that is calculated using as variables a respiratory motion feature and a body motion feature that are respectively extracted from respiratory motion index values and body motion index values of the subject measured in time series. The sleep state function is a function including coefficient parameters that are set based on learning data including sleep stage determination results by a measurement of a sleep state for calibration, and respiratory motion features and body motion features that are measured simultaneously with the measurement for calibration.

Abstract: The present application describes fitness facilities that include DEXA scanners, and methods of use thereof to establish or modify fitness and/or nutritional regimens for patrons of the fitness facilities. Various fitness facilities are described in which the interpretation of DEXA scan results is performed either on- or off-site. The fitness facilities of the invention can include a counseling center staffed with fitness trainers and/or nutrition experts for counseling subjects on issues relating to fitness and/or nutrition.

Abstract: A relationship relating a load of exercise and a user's aerobic capacity may be determined as follows. A processor circuit of a device may retrieve, from a memory, a prior probability distribution of the load of exercise and a prior probability distribution of the user's aerobic capacity. The processor circuit may compute a joint prior probability of the load of exercise and the user's aerobic capacity. The processor circuit may compute a joint likelihood of the load of exercise and the user's aerobic capacity based on data indicative of a measured time-stamped work rate and a measured time-stamped heart rate. The processor circuit may combine the joint prior probability and the joint likelihood to produce a joint posterior probability. The processor circuit may use the joint posterior probability to determine a relationship relating the load of exercise and the user's aerobic capacity and output a calorie calculation.

Abstract: Provided is an electronic device to monitor a user's biological measurements in two stages, where the first stage determines whether to make measurements and/or appraisals in the second stage.

Abstract: Embodiments of the present disclosure provide techniques and configurations for an apparatus for a user's physiological context measurements. In one instance, the apparatus may include a head-fitting component to be mounted at least partly around a user's head, and a sensor disposed on the head-fitting component to generate a signal indicative of a user's physiological context in response to contact with the user's head. The physiological context may comprise a respiration cycle, and the sensor may sense vibration in a portion of the user's head produced in response to the respiration cycle. The apparatus may further include a controller coupled with the sensor, to process the signal and generate data indicative of the physiological context of the user. Other embodiments may be described and/or claimed.

Abstract: An earpiece includes an earpiece housing, at least one biometric sensor disposed within the earpiece, a wireless transceiver disposed within the earpiece for voice communications, an intelligent control operatively connected to the at least one biometric sensor and the wireless transceiver, a speaker operatively connected to the intelligent control, and at least one microphone operatively connected to the intelligent control. The earpiece is configured to monitor biometrics of a user using the at least one biometric sensor, communicate biometric data to the user, detect a crisis level event, and communicate occurrence of the crisis level event using the wireless transceiver.

Abstract: A cast equipment including a fixed element, a filling device with a first site fastened to the fixed element, and a pressure sensor attached to the filling device is disclosed in this application. The pressure sensor is able to detect and collect pressure data, and the fixed element has a first container and a shape-retaining moldable material inside the first container. The present application provides an equipment to detect a pressure data to a casted region. A method for using the cast equipment is also provided in this application.

Abstract: An electronic skin is manufactured by disposing an oxide thin film transistor (TFT), a pressure sensor, and a temperature sensor on a flexible substrate. The pressure sensor and the temperature sensor are respectively located on two sides of the flexible substrate. The oxide TFT includes a first TFT and a second TFT. The pressure sensor is configured to drive the first TFT, and the temperature sensor is configured to drive the second TFT. The method for preparing the electronic skin is to form an oxide TFT, a pressure sensor, and a temperature sensor by means of etching and deposition on a flexible substrate whose double sides are covered with conductive materials. The electronic skin provided in the present invention may simultaneously measure pressure and temperatures, and has a simple structure, a low working voltage, small power consumption, high sensitivity, and small interference between sensor signals.

Abstract: An earpiece may include an earpiece housing, an intelligent control disposed within the earpiece housing, and a glucose sensor operatively connected to the intelligent control. The intelligent control may be configured to determine glucose levels associated with a user of the earpiece using the glucose sensor. The earpiece may further include a wireless transceiver disposed within the earpiece housing, the wireless transceiver operatively connected to the intelligent control. The glucose sensor may be a non-invasive glucose sensor such as a near infrared glucose sensor. The earpiece housing may be configured to position the glucose sensor against a wall of the external auditory canal.

Abstract: The disclosed devices and methods provide one or more sensors associated with a nasal insert to provide data on respiratory health from within a patient's nasal passage. The nasal insert may simply be a vehicle for carrying one or more sensors, or the nasal insert itself may form part of the treatment. For example, the nasal insert may be used to increase airflow through the nasal passages. The nasal insert can contain a bio-sensor that may be affixed to an internal or external surface of the insert, be embedded partially or fully in an internal or external surface of the insert, or may pass through an internal or external wall of the nasal insert. In addition, the insert may include grooves that can be used to attach a sensor to the insert, for example, in place of or in conjunction with a filter.

Abstract: Provided is a multiple-electrode monorail guide catheter for use in vascular insertion, including: an elongated catheter main body having a proximal end and a distal end; a guidewire inlet opening on the distal end; a guidewire outlet opening; an operation tube; a terminal unit on the proximal end; an electrode assembly having a double-lumen structure composed of an outer tube having electrodes on an outer surface of the outer tube and an inner tube independently provided from the outer tube, allowing insertion of a guidewire, having an outer diameter smaller than an inner diameter of the outer tube, and being accommodated within an outer tube lumen; a clearance defined by the outer tube luminal surface and an inner tube outer circumferential surface; and lead wires extending from the electrodes to the terminal unit on the proximal end and being inserted into the lumen of the outer tube.

Abstract: A catheter assembly including an elongate catheter tube is disclosed. The number of lumens defined by the catheter tube can vary as a function of longitudinal length along the catheter tube. For instance, the catheter tube can define three lumens from the proximal end of the catheter tube and terminate one of the lumens at an intermediate termination point such that only two lumens are defined further distally along the catheter tube. A sensor can be placed in the terminating lumen so as to isolate it from the other lumens and from blood or other body fluids while still enabling the sensor to reside within the patient body when the catheter tube is positioned in the patient for use. In addition to this, various other lumen transition and sensor configurations are disclosed.