Abstract: An absorbent article is provided with a central elastic material for positioning in a state in which it is extended in the front/rear direction in the outer direction in relation to an absorbent body, and an elastic material cover sheet which abuts the outer direction side surface of the central elastic material. The elastic material cover sheet covers an extension region where the central elastic material is positioned in an extended state, and a non-extension region where the central elastic material is positioned in a non-extended state. An adhesive agent for fixing in the extended state is coated onto the central elastic material of the extension region. An adhesive agent is coated onto at least the non-extension region of the outer direction side surface of the elastic material cover sheet, and the adhesive agent coated onto the outer direction side surface penetrates to the inner direction side surface of the elastic material cover sheet.

Abstract: A secondary internal topsheet and leg wrap structure is provided in a disposable absorbent garment such as a diaper or training pants. The leg wrap structure has a base layer, a top layer, and an elastic construction disposed inbetween. The elastic construction includes a plurality of spaced apart elastic elements that are aligned in a generally in generally parallel relation. The leg wrap structure and secondary topsheet provides for the efficient formation of a reservoir and a plurality of fluid dams each capable of capturing a quantity of fluid to minimize the occurrence of fluid leaks from the absorbent article. Methods of forming such absorbent articles are disclosed.

Abstract: The present invention relates to a method of applying absorbent gelling material (AGM) granules by indirect printing onto an carrier layer for use in an absorbent article, particularly diaper for babies or adults, training pants, pull-up diapers (diaper pants), sanitary napkins, panty liners or the like. These articles typically comprise the carrier layer with the AGM particles together with further layers, making up the complete article.

Abstract: An absorbent article includes front and rear portions and a fastener for connecting side edges of the front and rear portions. The fastener includes a grasping element attached to an outer surface of the fastener to provide for grasping by the wearer or caregiver. The grasping element may be formed of flexible material and may have a variety of configurations, including a tube, a flange, a tunnel or a pocket.

Abstract: A safety restraint adapted for securing a personal mobility vehicle in a transport vehicle, against movement in a direction opposite to the direction of normal motion of the transport vehicle, the safety restraint comprising: a retractor comprising a spool on which an elongate piece of material is wound; the elongate material being configured to be attached at one end to the personal mobility vehicle; a slider bar adapted to be fixed to the transport vehicle; and wherein the retractor is mounted on the slider bar, in a manner which allows the retractor to slide in the direction of normal motion of the transport vehicle, and prevents the retractor moving in the opposite direction on the slider bar.

Abstract: This invention pertains to medical accessories for wheelchairs. It specifically relates to a headrest system that can be attached to a wheelchair, medical chair, or bed for home use, hospitals or other medical centers. It is intended for use of patients with swallowing difficulties to prevent Aspiration Pneumonia during eating or drinking. This headrest would support the head in the proper position for deglutition that blocks the larynx entrance during swallowing and prevent food or drink from entering into respiratory system. Wherein, a serious problem for patients with lung diseases is, inhaling foreign material such as food and drink that could ultimately cause lung infection. This invention addresses this concern. The novelty introduced here is the design and technicalities of an attachable headrest with adjustable length and tilting head cushion.

Abstract: A patient support includes a plurality of stacked layers of cushioning material, at least two of the layers comprising foam, each of the at least two layers having a different firmness, and at least one of the layers comprising a gel-based cushioning layer.

Abstract: A patient support includes a bladder layer with a plurality of bladders, a pneumatic supply system, and a plurality of tubes in fluid communication with pneumatic supply system. The tubes are coupled to and guided by the bladder layer so that the tubes and bladder layer may remain in close registry when being handled, for example, either during the assembly process or cleaning process.

Abstract: The present invention relates to a patient transfer apparatus for assisting in the movement of a patient on a supporting surface.

Abstract: Apparatus for use in isolating a subject, the apparatus including a frame movable between collapsed and erected configurations, a body supported by the frame, wherein in the erected configuration, the body defines an internal volume for containing a subject to thereby substantially isolate the subject from a surrounding environment and a door actuator supported by the frame for moving a door between open and closed positions to thereby provide access to the internal volume.

Abstract: A shroud guard is provided for protecting a height adjustment mechanism used to raise and lower the height of an operating room table. The shroud guard includes a support frame secured to a table base of the operating room table. The support frame includes a bracket with an attachment member and an upstanding shield support secured to the attachment member. The attachment member is secured to the table base via a fastener to inhibit movement along the table base. A shield is removably secured to the upstanding shield support and extends transversely over the table base of the operating room table and across the height adjustment mechanism to inhibit foreign objects from contacting the height adjustment mechanism.

Abstract: An adjustable-position support arm comprising a plurality of tubular elements connected to one another in series of joints; a locking mechanism disposed at each joint so that a first portion of the locking mechanism is secured to a first tubular element of that joint and a second portion of the locking mechanism is secured to the second tubular element of that same joint wherein the locking mechanism is configured in a locked condition to prevent rotation of the first tubular element relative to the second tubular element selectively unlocked condition so that the first tubular element is rotatable relative to the second tubular element; and an actuator for actuating all of the locking mechanisms from their locked condition to their unlocked condition.

Abstract: A head support device for use with a bed includes a head-receiving component; a base component adapted to rest on a stable surface; a vertically-oriented spine component extending upwards from the base component to the head-receiving component; and at least one bed-connection structure extending horizontally from an intermediate position along the spine component.

Abstract: A device for supporting a patient's arm includes a rail clamp configured to be secured to a rail or other structure on a table such as an operating table. The rail clamp includes a clamp body and a socket configured to receive a base of an attachment such as a support arm or lateral brace. The base may be inserted longitudinally in the socket on the rail clamp. A stabilizer bar extends from the base in some embodiments. The base is moveable in the socket such that the stabilizer bar may be raised or lowered relative to the rail clamp. One or more modular attachments for supporting various regions of a patient's arm may be secured to the stabilizer bar or the rail clamp.

Abstract: A universal reclining armrest system for use with an articulated examination chair. The system includes an armrest adapter having a universal aperture for receiving a post portion of an armrest assembly. The armrest adapter further includes a splined peg for coupling to a pivoting mechanism of an articulated chair. The pivoting mechanism enables the chair to move throughout an operable range of motion while maintaining a fixed rotational position of an attached armrest adapter. The armrest assembly further includes an adjustable joint to provide 360° of rotational adjustment to the armrest relative to the fixed position of the armrest adapter.

Abstract: A method of vibration treatment in at least one nasal cavity of a human subject is provided. The method includes the steps of: inserting a first stimulation member in a first nasal cavity; inserting a second stimulation member in a second nasal cavity; securing the first and second stimulation members such that the stimulation members are in fixed positions within the nasal cavities prior to vibration stimulation; arranging each of the first and second stimulation members to abut against tissue within each of the first and second nasal cavities at a first and second pressure; and imparting vibrations to tissue in at least one of the first and second nasal cavities via at least one of the first and second stimulation members.

Abstract: A lower body electrical muscle stimulation exercise system for exercising the legs of a paralyzed user which incorporates electrical stimulation of leg muscles. The device is portable, light-weight and functional. The device is placed in front of a user who is sitting in a chair. The user's legs may be placed on moveable leg supports. An electric motor rotates a bicycle crank assembly which moves the legs of a user in a back and forth bending motion. Electrical stimulation is then activated which contracts or relaxes the leg muscles. The stimulation is sequentially activated by a Master Processor and a Transcutaneous Electrical Nerve Stimulator (TENS) unit. The present invention is designed to stop the deterioration of the leg muscles and restore the functionality of the legs.

Abstract: A resistive exoskeleton control system has a controller generating a positive resistance by shaping a closed loop integral admittance of a coupled human exoskeleton system wherein a frequency response magnitude of the integral admittance is lower than that of a natural human joint for desired frequencies of interest and generating an assistance ratio of approximately zero for the desired frequencies of interest.

Abstract: A compression treatment system is provided that detects the number of and type of garments connected thereto. The system includes a plurality of ports, valves connected thereto and a number of garments having one or more bladders. The bladders are in fluid communication with a fluid source in a pneumatic circuit, to provide compression therapy once a user confirms the number of and type of garments connected to the system for use by a patient. A single pressure sensor communicates with a plurality of detected bladders located in the one or more garments.

Abstract: Systems and methods for treating facial soft tissues of a patient in a healthcare or cosmetic treatment environment such as, for example, a spa, clinic, or a medical practitioner's office are presented herein. The facial treatment system includes a facial stimulator instrument and/or an acoustic oscillator to deliver therapeutic stimulation to the facial tissues of a patient including percussive massage, electrical stimulation, and acoustic stimulation. A facial treatment application executing on a processor of a computing device identifies a treatment protocol and operates the facial stimulator instrument and/or acoustic oscillator to implement the facial tissue treatment.

Abstract: A needle system for use by physical therapist in intramuscular stimulation procedures. A cylindrical non-conducting grip is located at a needle second end of a linear needle. A needle first end is pointed. An electrical connecting node is located on a needle between the needle first end and the needle second end. A second grip may be disposed on the needle such that the electrical connecting node is positioned in between the first and second grips. The electrical connecting node is operatively connected to the needle. A device generating electrical impulses is operatively connected to the electrical connecting node.

Abstract: A medicine container and a method of forming the medicine container are described herein. The medicine container includes a bottle and a bottle cap removably connected to the bottle. A dose cup is disposed over the bottle cap, the dose cup having an opening defined by a perimeter. A tamper band is monolithically coupled to the perimeter of the dose cup. The tamper band is directly connected to the bottle by a destructively attached connection.

Abstract: A prescription compliance system including a pill tray having a plurality of sequence compartments within a frequency section and dosage tables on prescription container systems that provide graphical dosage instruction information for the patient in dosing each of the sequence compartments of the pill tray with a plurality of prescribed medications.

Abstract: Medical device designs for enteral nutrition that inhibit the relative motion of one device member to another device member are herein disclosed. The gastric and/or intestinal feeding tube shaft is disposed of teeth, furrows, ridges, indentions, tabs, or corrugations that operate with an external retaining member. Alternative embodiments utilize an external retaining member with a collet fitting that applies pressure against the gastric and/or intestinal feeding tube shaft. The assemblies prevent the relative motion of the internal retention member relative to the external retaining member and assist in maintaining the internal retention member against the gastric wall.

Abstract: The invention relates to a dental composition comprising filler (F1) comprising aggregated nano-sized particles in an amount of from about 30 to about 70 wt. %, filler (F2) comprising agglomerated nano-sized particles in an amount from about 1 to about 20 wt. %, hardenable component (A1) being an urethane(meth)acrylate with a functionality of at least 2 and having a molecular weight from about 400 to about 3,000 g/mol,-hardenable component (A2) being a radically polymerizable (meth)acrylate with a functionality of at least 2 being different from component (A1), redox curing initiator system, the dental composition not comprising non-agglomerated nano-sized filler in an amount above about 10 wt. %, wt. % with respect to the weight of the whole composition. The dental composition is in particular useful as or for production of permanent crown and bridges, inlays, onlays and veneers.

Abstract: Described herein are systems for removing selected components, e.g., stabilizing agents or preservatives, from a liquid composition just prior to use, using activated charcoal or an affinity matrix filter, together with variant and alternative designs, methods of making and using the product, and components thereof.

Abstract: An object is to provide dispersion containing lipid peptide type compound useful as low molecular weight gelator, such as lipid dipeptide and lipid tripeptide, and dissolution accelerator capable of dissolving the lipid peptide type compound at lower temperature and more easily. It is also an object to provide dispersion that can form hydrogel by simpler method and under milder condition (low temperature) and from which gel can be obtained as gel having high thermal stability, and provide method for forming the gel. Dispersion including: a lipid peptide type compound in which peptide portion formed by repetition of at least two or more identical or different amino acids is bonded to lipid portion including C10-24 aliphatic group; dissolution accelerator having, in molecules thereof, hydrophilic portion and hydrophobic portion, the hydrophilic portion having betaine structure; and water; and method for producing hydrogel by use of the dispersion.

Abstract: Provided is a cosmetic product for hair bleaching or hair dyeing comprising a first agent comprising an alkali agent, a second agent comprising hydrogen peroxide, and a nonaerosol foamer container for discharging a mixed solution thereof in the form of foam, the mixed solution comprising the following components (A) to (C), (A) a anionic surfactant comprising sulfuric acid group, (B) anionic surfactant comprising carboxy group, and (C) a polymer comprising a diallyl quaternary ammonium salt as a constitutional unit and having a charge density of 5.5 meq/g or more and 8.0 meq/g or less.

Abstract: The present invention discloses an oral composition comprising a combination of salivating agents and gum sensates in an orally acceptable carrier useful in treating and/or alleviating the symptoms associated with xerostomia. Additional components common in oral compositions may also be used, in order to potentiate the effect. Such components may be chosen among humectants, mucoadhesive polymers, water retention agents, antioxidants, antimicrobials, breath fresheners.

Abstract: Systems and methods for skin rejuvenation are disclosed herein. In an embodiment, a skin rejuvenation system includes a unit dose of a booster product that includes active ingredients of ferulic acid and phloretin; a unit dose of at least one exfoliating product that includes active ingredients of ferulic acid and phloretin in combination with fruit acids or alpha hydroxyacids; and a unit dose of a nano-additive product for enhancing penetration of the active ingredients. A method for skin rejuvenation includes applying topically, to a skin surface to be treated, a booster product including active ingredients of ferulic acid and phloretin; applying topically, to the skin surface, at least one exfoliating product including active ingredients of ferulic acid and phloretin in combination with one of fruit acids or alpha hydroxyacids; and applying topically, to the skin surface, a nano-additive product for enhancing penetration of the active ingredients.

Abstract: Succinic acid esters of resveratrol and topical compositions containing the esters.

Abstract: The present invention provides a composition containing (A) and (B), which shows a decreased peculiar odor of acylproline and a salt thereof, has a moist feeling and is superior in the stability: (A) acylproline represented by the formula (1) or a salt thereof (wherein an acyl group represented by R1—CO— is an acyl group induced from saturated or unsaturated fatty acid having 3-23 carbon atoms) (B) a zinc salt of pyrrolidone carboxylate.

Abstract: Compositions comprising one or more compounds expressed by fetal tissues for modulating skin conditions, methods of identifying the compounds, and methods of making and using the compounds are provided.

Abstract: A dental bleaching composition comprises a dental bleaching agent and a polyvinylpyrrolidone thickening agent. The bleaching composition may include a liquid component, flavoring agents, a basic substance and desensitizing agents, as desired. Polyvinylpyrrolidone avoids acid etching and chelation of teeth that were problematic in bleaches using carbomer as a thickener. A delivery system for delivering the bleaching composition comprises the aforementioned dental bleaching composition in combination with a moisture-resistant barrier layer such as a dental tray or a flexible strip of material.

Abstract: Described herein are oral care compositions comprising a crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, together with particular co-polymers as additional excipients; including some embodiments which further comprise a calcium abrasive.

Abstract: A cosmetic product for hair bleaching or hair dyeing comprises a first agent containing an alkali agent, a second agent containing hydrogen peroxide, and a nonaerosol foamer container for discharging a mixed solution thereof in the form of foam, the mixed solution containing 1 mass % or more of the components (A) and (B) in total, wherein a mass ratio (B)/(A) is 0.25 or more. (A) 0.01 to 5 mass % of an anionic surfactant containing sulfuric acid group represented by the following formula R—O—(CH2CH2O)n—[CH2CH(CH3)O]m—SO3M wherein R represents a C8-25 hydrocarbon group, n and m each represent an average number of moles added of 0 to 50, and M represents an alkali metal or NH4, and (B) a polymer comprising a diallyl quaternary ammonium salt as a constitutional unit and having a charge density of 5.5 meq/g or more and 8.0 meq/g or less.

Abstract: A composition for delivery of a hydrophobic bioactive agent is provided that provides for a partially solubilized storage solution that upon exposure to the air results in a fully solubilized bioactive agent in a molecular form for optimal delivery to the skin of a subject. The composition is used for the therapeutic treatment or diagnosis of numerous skin conditions such as acne, wrinkles, inflammation, and epidermal or musculoskeletal pain.

Abstract: A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable polymer, a magnetic nanoparticle, the biological targeting agent human serum albumin, and a therapeutic pharmaceutical composition. The composite nanoparticles are prepared by oil-in-oil emulsion/solvent evaporation and high shear mixing. An externally applied magnetic field draws the magnetic nanoparticles to affected areas. The biological targeting agent draws the nanoparticles into the affected tissues. Polymer degradation provides controlled time release delivery of the pharmaceutical agent.

Abstract: The embodiments herein provide a nano-carrier system for delivering a long-acting injectable drug of morphine and a method of synthesising the same. The morphine entrapped nanoparticles are prepared using a lipid/phospholipid core which is coated by a polymer. The lipid and phospholipid are dissolved in organic solvent. This solution is transferred into an aqueous phase consisting of distilled water or a buffer. A solution of polymer is added drop wise. The drug entrapped nanoparticle formation is achieved by diffusion of the organic solvent within the aqueous solvent to obtain the nanoparticles. The drug gets entrapped within the nanoparticles via the anti-solvency effect of the aqueous matrix. The resulting drug nanocarriers are capable of releasing the drug in a slow rate upon injection. The synthesized drug carrying nanoparticles are cryopreserved stored for future administration. For better storage, the nanodispersion is dried to form a powder.

Abstract: There is provided glucagon formulations suitable for preparing coatings on microneedle patches for the transdermal delivery of glucagon. The coated patches may be used for the treatment of low blood sugar in diabetic patients. Also provided are glucagon loaded patches, methods for their preparation, and methods of their use.

Abstract: An ocular composition can include a polymer matrix and an antibiotic dispersed in the polymer matrix. The polymer matrix can contain a thiolated hyaluronic acid moiety cross-linked to a second moiety. The composition can be configured for placement in or on an eye of a subject to provide controlled release of the antibiotic to the eye. A method of treating or preventing an ocular disease can include providing an ocular composition and applying the ocular composition to a surface of an eye of a subject to provide controlled release of the antibiotic to the eye. The ocular composition can include a polymer matrix and an antibiotic dispersed in the polymer matrix. The polymer matrix can include a thiolated hyaluronic acid moiety cross-linked to a second moiety.

Abstract: Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Abstract: Provided are ingestible polymeric formulations and oral dosage forms for the reduction of gastric volume in the treatment of overweight and obese patients. The formulation includes an acid-sensitive, gelatin coating over a dehydrated hydrophilic polymer. When ingested, the acid-sensitive coating is quickly dissolved by gastric secretions and the hydrophilic polymer is exposed to the aqueous environment of the gastric milieu. The polymer absorbs water and expands to the point that will not allow the polymer to pass beyond the pyloric valve, and the expanded polymer is therefore trapped in the stomach.

Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.

Abstract: The present invention relates in a first aspect to a method of coating surfaces of substrates with a lattice-like structure. In particular, the present invention relates to an in vitro method of coating surfaces by binding of epsin or a fragment thereof on the surface and, thereafter, binding of a compound forming the lattice like structure, in particular, binding of the clathrin heavy chain, to the epsin bound on the surface, thus, obtaining a coated substrate having a lattice like structure on the surface. In another aspect, the present invention relates to an in vitro method of producing nanometer-sized liposomes having a clathrin structure on its surface. In addition, substrates, like elements or devices, with coated surfaces having a lattice-like structure on the surface are provided obtainable by a method according to the present invention.

Abstract: The present invention includes compositions, methods of making and using the compositions for modulating the immune response in a subject by providing a vaccine composition having a pollen/spore disposed in a pharmaceutical carrier for delivery to a subject, wherein the pollen/spore comprises multiple pores that connect an outer surface of the pollen/spore to an inner cavity and one or more antigens disposed on the outer surface, in the inner cavity, in the multiple pores, or a combination thereof, wherein the one or more antigens modulate an immune responses in the subject.

Abstract: A solid oral pharmaceutical composition in the form of a tablet consisting of a core including a Krebs cycle precursor salt as active ingredient, and of a coating including a coating agent, the composition including from 40% to 80% by weight of this precursor salt on the basis of the total weight of the composition, the composition being able to release this salt in vitro, both in purified water at pH 7 and in a solution buffered at pH 1.3, with a dissolution device in accordance with the European Pharmacopoeia, at a rate of from 2 to 15% in 15 minutes, from 15 to 25% in 30 minutes, and from 30 to 50% in one hour. The composition is a usefeul medicament, in particular in the treatment and/or prevention of urinary lithiasis occurring at a physiological pH and/or during urinary acidosis and/or during hypocitraturia and/or during hypercalciuria and/or during hyperoxaluria.

Abstract: The present invention provides a film coated tablet comprising a first film coating layer comprising hydroxypropyl methylcellulose and a second film coating layer comprising polyvinyl alcohol, on a tablet containing choline alfoscerate as an active ingredient and magnesium aluminometasilicate as an additive; and a process for preparing the same.

Abstract: An oral enteric delivery system includes an outer shell assembled from multiple solid shell segments joined together by a binder. The binder does not dissolve upon exposure to the gastric environment, but it dissolves in the upper small intestine, causing the shell to disintegrate and causing the payload contained within the shell to be released in the digestive tube downstream of the stomach.