Abstract: Systems, devices and methods for use in liposuction and infusion medical procedures including handheld devices, micro-cannulas, curved cannulas vacuum pressure changing features.

Abstract: Suction devices are disclosed comprising a side wall defining a lumen, an open proximal end sized to provide coupling to a suction source, a distal wall opposite the open proximal end, the distal wall at least partially occluding the lumen, the side wall extending between the proximal end and the distal wall, a plurality of vent holes in communication with the lumen defined in the side wall, and at least one vent hole in communication with the lumen defined in the distal wall. Also disclosed are methods and additional suction devices.

Abstract: Reduced-pressure sources, systems, and methods involve using a vacuum pump that is disposed within a sealed space to produce reduced pressure. The exhaust from the vacuum pump is exhausted from the sealed space through pores in an enclosure member that is made of a polymeric, porous, hydrophobic material. Other devices, systems, and methods are disclosed.

Abstract: A negative pressure wound therapy apparatus can include a wound dressing, a fluid collection container, a vacuum pump comprising a pump motor, and tubing. Additionally, the apparatus can include a pressure sensor that measures a pressure in the tubing. One or more tubes can channel a fluid between the wound dressing, the fluid collection canister, and the pump. In addition, first and second control circuits can be provided for controlling the pump motor without using a processor. The first control circuit can generate a difference signal between a desired pressure input and a pressure sensor input, and can further generate a motor control signal responsive to the difference signal. Moreover, a second control circuit can provide an override signal based at least in part on the difference signal and at least one reference signal. The override signal beneficially overrides the motor control signal to prevent the pump motor from stalling.

Abstract: Apparatus (10, 200) for the provision of TNP therapy to a wound is described, the apparatus (10, 200) including: a waste canister (22, 204) into which fluid is aspirated from a wound by aspiration pump means (44, 248) and a fluid flow path (420, 422) for at least a part of said aspirated fluid on an outlet side of said aspiration pump means (44) wherein said fluid flow path (420, 422) on the outlet side comprises a silencing system (400) having a plurality of silencing elements (402, 404, 406) therein.

Abstract: The suction system in the surgical area is part of the operation room, one of its functions is helps to aid the vision of the surgeon and the surgical team. Currently the operation rooms use a regular suction tubing which is just one female connector to the suction system, a body tube and a female connector to the surgical field. With the modification and adaptation of the regular suction tubing, we will get the new suction tubing in “Y” two-way for surgery, one unit will do the job of 2 regular suction tubing, which will help in saving time to connect, and avoid changing tubes between instruments during the surgery (uncomfortable), less tangles in the surgical field and it will impact in the environment since we will producing fewer PVC which means less material to be disposed.

Abstract: A blood component separation device for separating a plurality of blood components from blood sampled from a blood donor, and collecting platelets, includes: an donor calculation unit that calculates a predicted platelet recovery rate from a hematocrit value of the blood and a platelet concentration of the blood, and calculates a recommended processing amount of the blood recommended for collecting a target number of units of platelets on the basis of the calculated predicted platelet recovery rate, wherein the operating unit sets the predicted platelet recovery rate calculated from any the hematocrit value and any the platelet concentration to be smaller by a predetermined value ? when the blood donor is female than that when the blood donor is male.

Abstract: Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal end of the catheter body and the impeller, wherein the diffuser includes a flow directing surface.

Abstract: An implantable blood pump includes an impeller rotatable about a rotational axis, having a body with a bottom surface at a downstream end and a central opening centered about the axis extending at least partially through the body from the bottom surface. A projecting element, e.g., a shaft, extends from below the bottom surface into or through the opening to support the impeller. The body can be configured to drive a primary downstream blood flow along an exterior of the body to beyond a peripheral edge of the bottom surface, and to provide a secondary downstream blood flow through the opening and along the bottom surface to beyond the peripheral edge, the secondary flow improving washing of a bearing surface.

Abstract: A centrifugal pump includes a rotating shaft, a pump substrate, a housing and an impeller. The pump substrate has a driving unit configured to rotate the rotating shaft. The housing has an inlet and an outlet and forms a pump chamber with the pump substrate. A body fluid sucked from the inlet flows through the pump chamber. The impeller is housed in the pump chamber and is configured to use the rotating shaft as an axis. The pump substrate has a magnetism generating source. The rotating shaft protrudes into the pump chamber from the pump substrate, and is pivotally supported on the pump substrate. A magnetic fluid is disposed on at least one of spaces formed among the pump substrate, the rotating shaft, and the impeller.

Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.

Abstract: The heart pump includes: a rotary impeller inserted in the systemic ventricle, the rotary impeller being provided with: a sealing membrane sutured onto the outer wall of the heart so as to secure the rotary impeller to the wall of the heart; a casing arranged inside the systemic ventricle such as to be able to suction and then discharge the blood; a preferably brushless motor connected to the casing and arranged inside the systemic ventricle and/or in the body of the ventricle, so as to facilitate maintenance; a managing unit installed in the epigastric region and including a preferably rechargeable power source and a unit for controlling the rotary impeller; a wired link between the managing unit and the rotary impeller; and a system for transmitting haemodynamic and rhythmic data measured by the heat pump via telemedicine.

Abstract: A system for improving heart muscle response during a pre-ejection phase in the heart muscle pumping cycle requires a catheter having a pressure transducer and a fluid device mounted at its distal end. Also included is a pump connected to the proximal end of the catheter in fluid communication with the fluid device. A computer will activate the pump in response to a predetermined signal from the pressure transducer to inject and maintain an increased fluid volume in the pumping chamber of the heart for a predetermined time interval ?t during the pre-ejection phase. This supplements the isometric pressure in the heart's pumping chamber in preparation for a subsequent ejection of blood from the pumping chamber.

Abstract: A blood pump has a hollow body in which an impeller with a spiral blading produces an axial propulsion of blood along the impeller, as well as an at least partly actively stabilized magnetic bearing device and a hydrodynamic bearing device for the impeller. The impeller may be set into a rotation about a rotation axis of the impeller with a motor stator located outside the hollow body. The hollow body has an inlet for the flow of blood into the hollow body in an inflow direction which is essentially parallel to the rotation axis, and an outlet for the outflow of the blood out of the hollow body in an outflow direction which is offset to the rotation axis of the impeller to produce a non-zero outflow angle (?) between the inflow direction and the outflow direction. A total artificial heart can be formed from two such blood pumps.

Abstract: A method for extracorporeal blood treatment using a medical device including at least a dialyzer device, with the following steps: start of blood treatment by means of hemodialysis on the basis of default values for the hemodialysis; determination of current values or ratios of at least one blood flow, an ultrafiltration quantity, a substitution quantity or a type of substitution; recording of a therapy progress on the basis of an output signal of a sensor means; determination of a time of formation of a secondary membrane on the dialyzer by determination of a cross rate in the dialyzer device; change from the hemodialysis to a hemodiafiltration with post-dilution after a predetermined period of time has elapsed; and regulation of the substitution quantity during hemodiafiltration with post-dilution. Corresponding tools for carrying out the method are arranged in a device for extracorporeal blood treatment.

Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Abstract: The present invention relates to a heating device for one or more components of an extracorporeal circuit of a blood treatment device, in particular of a dialyzer, an adsorber or a filter, wherein the heating device has at least one reception region for the named component and at least one heating element for heating the component located in the receiver, wherein the heating device has a plurality of layers, with at least one layer being a flexible layer or elastically deformable layer.

Abstract: The present invention relates to a dialysis solution containing bicarbonate, calcium and phosphate, wherein the dialysis solution contains phosphate having a concentration in the range from up to 0.4 mmol/l, preferably in the range from up to 0.375 mmol/l, or in the range from up to 0.25 mmol/l, and particularly preferably in the range from up to 0.2 mmol/l.

Abstract: Embodiments include a consumable medical device comprises a rigid cartridge to which a film is adhered to form a fluid channel and a damper chamber. A portion of the film forming the damper chamber has a wave-like shape adapted to roll onto a tip of a damper. The damper has a plunger to minimize peristaltic pressure in the channel The cartridge may include conductivity measurement channels. Crosstalk may be minimized by using different frequencies or time division for reading the channels. A stable dialysate concentrate containing sodium lactate may be used or generated with the system.

Abstract: A dialysis machine (e.g., a peritoneal dialysis (PD) machine) can include a pressure sensor mounted at a proximal end of a patient line that provides PD solution to a patient through a catheter. During treatment, an occlusion can occur at different locations in the patient line and/or the catheter. Elastic waves may be generated at a pump that introduces (e.g., for fill cycles) or withdraws (e.g., for drain cycles) the solution into/out of the patient line. For example, when the solution is introduced or withdrawn suddenly, elastic waves travel distally down the patient line until they encounter the occlusion, and are then reflected back (e.g., toward the pressure sensor).

Abstract: A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.

Abstract: A method of draining a device for extracorporeal blood treatment, wherein the device comprises a dialyzer which is divided by means of a membrane into a first chamber and a second chamber, an arterial line connected to a blood inlet of the first chamber, a venous line connected to a blood outlet of the first chamber, a dialysis fluid line for fresh dialysis fluid connected to a dialysis fluid inlet of the second chamber and a dialysis fluid line for used dialysis fluid connected to a dialysis fluid outlet of the second chamber, a blood pump disposed in the arterial line, a venous expansion chamber disposed in the venous line and an air detector unit downstream of the venous expansion chamber, and wherein the method comprises the following steps of: connecting a patient-side port of the arterial line to a patient-side port of the venous line; generating a negative pressure in the second chamber; operating the blood pump in a first direction and draining the arterial and venous lines in the first direction via

Abstract: A system associated with a medical treatment device for detecting a condition of a patient includes an input device including at least a camera or a microphone. The system also includes a medical treatment device with a controller/classifier and at least one of flow controller, a pump, and/or an alarm output. The controller/classifier has at least a video-image processor or an audio processor configured to recognize a face and a body or to recognize changes in skin color, facial expression, or body position. The controller/classifier may also recognize speech and classify predefined normal and irregular sound patterns, and output state data corresponding thereto. The controller/classifier is connected to apply the state data to the at least one flow controller, pump, and/or alarm output. The controller/classifier is further adapted to control the at least one flow controller, pump, and/or alarm output responsively to the state data.

Abstract: The invention relates to a container in the form of a bag having a flexible bag wall at least in a region, in which a first and a second hollow channel section, pass through the bag wall in a fluid-tight manner, wherein the hollow channel sections respectively have an open channel end that is located within the container for connecting the open channel ends to one another in a separable and fluid-tight manner.

Abstract: An extracorporeal alarm suppression method is arranged to be carried out in a continuous renal replacement therapy and/or chronic hemodialysis device and includes the steps of monitoring vascular access pressure, including arterial and/or venous pressure, of a patient using a vascular access pressure monitoring means; detecting an access pressure alarm situation if the arterial or venous pressure is out of predetermined alarm limits; when a first access pressure alarm situation is detected, setting the device to an alarm suppression state reducing the blood flow and therapy flows using an alarm suppression state setting means; detecting that a predetermined alarm suppression state condition is met using a predetermined alarm suppression state condition detecting means, the predetermined alarm suppression state condition including at least a predetermined waiting time having passed or a parameter threshold having been reached after the first access pressure alarm situation has been detected; and when a further

Abstract: The present invention relates to an apparatus comprising at least one multi-lumen tube, wherein the tube has a first group of lumens and a second group of lumens wherein the lumens of the second group are arranged around the lumen(s) of the first group, and wherein the lumen(s) of the first group serve the transportation of at least one first fluid, and wherein the lumens of the second group are filled with at least one functional fluid, wherein the apparatus furthermore comprises at least one actuator which is in communication with at least one of the second lumens and is configured such that at least one property of the functional fluid can be changed by means of the actuator.

Abstract: A carrier assembly and related sterile kits are disclosed. The carrier assembly is configured to be used with a sensor assembly for determining a characteristic of a human body. The carrier assembly comprises a frame member comprising a sidewall defining a central opening configured to receive at least a portion of the sensor assembly and laterally extending wing members hingedly attached at a proximal end thereof to the sidewall of the frame member. The laterally extending wing members each comprise a cavity proximate a distal end thereof and configured to receive a magnet. Related kits and systems are also disclosed.

Abstract: Systems and methods for visualizing fluid enhanced ablation therapy are described herein. In one embodiment, a method for ablating tissue is provided that includes inserting an elongate body into a tissue volume, heating an imageable fluid within the elongate body to transform the imageable fluid into an imageable therapeutic fluid, delivering the imageable therapeutic fluid into the tissue volume to deliver a therapeutic dose of thermal energy to the tissue volume, and imaging the tissue volume to determine the extent of the tissue volume containing the imageable therapeutic fluid. The imageable therapeutic fluid can indicate the extent of the tissue volume that has received the therapeutic dose of thermal energy.

Abstract: Methods and systems for providing modular components in an integrated infusion device and analyte monitoring system where the components are independently repleaceable are provided.

Abstract: A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveable by the actuator once the cartridge is inserted into the drive unit.

Abstract: A control mechanism for a medicament delivery device is provided having a medicament container connection mechanism, for connecting a medicament container with a medicament delivery member; a penetration and withdrawal mechanism, for actuating a penetration and a withdrawal sequence; a medicament delivery drive unit, for expelling a medicament; an activation mechanism, for initiating a penetration and medicament delivery sequence; a stop mechanism, for initiating a withdrawal sequence; wherein the control mechanism further comprises a control member, linearly movable between a first position and a second position, which control member is connectable to the medicament container connection mechanism, to the penetration and withdrawal mechanism, to the medicament delivery drive unit, to the activation mechanism, and to the stop mechanism.

Abstract: A single core pin assembly (10) having a first core pin (12) and at least one second core pin (14), the first core pin (12) having a first end (16), a second end (18) and a first core pin body (20). The first core pin body (20) connects the first end (16) and the second end (18). The second core pin (14) has a first end (24), a second end (26), and a second core pin body (28) connecting the second core pin first end (24) and the second core pin second end (26). The second core pin first end (24) is configured to join with the first core pin first end (16) to form a common downstream channel (30). The core pin (10) may be placed in a mold and surrounded by a flowable material (e.g. plastic) to form a work piece.

Abstract: A selector valve for a medical fluid delivery device is disclosed. The valve includes a valve bore in fluid communication with an outlet channel, first and second outlet ports, and a selector valve body which includes a valve stem located within the valve bore and having a flow passage. The selector valve body is adapted to place the flow passage in fluid communication with one of the first outlet port, the second outlet port, and a shut-off position.

Abstract: A syringe pump includes a lead screw, a motor, and a sliding block assembly. The lead screw has threads and the motor is coupled to the lead screw to rotate it. The half-nut housing has a half nut and a barrel cam. The half nut is disposed within the half-nut housing. The half nut has half-nut threads at an end adjacent to the lead screw void. The half nut engages or disengages with the threads of the lead screw. The half nut includes a half-nut cam-follower surface and a half nut slot. The barrel cam is disposed within the half-nut housing and engages with the half-nut cam-follower surface. The barrel cam includes a pin to fit within the half nut slot such that the barrel cam rotates between a first position and a second position to actuate the half nut between the engagement position and the disengagement position, respectively.

Abstract: Methods, systems, and computer readable media for physiology parameter-invariant meal detection are disclosed. According to one system, the system includes at least one processor and a meal detection module implemented using the at least one processor. The meal detection module is configured to receive insulin intake information and blood glucose level information for a user, to detect a meal event using a physiology parameter-invariant meal detection algorithm, and after detecting the meal event, to perform at least one control action associated with insulin management.

Abstract: Embodiments disclosed herein include systems and methods for administering a drug over a time period. One embodiment of a system includes an administration unit, a housing that houses the administration unit, and a controller unit adapted to receive an alarm triggering signal. Also included in some embodiments is an alarming unit that is adapted to generate an alarm signal on reception of the alarm triggering signal. Some embodiments include a patient state monitor that includes a motion-sensitive sensor unit that is reactive on patient motion. The patient state monitor may be adapted to process a sensor signal generated by the motion-sensitive sensor unit. The patient state monitor may also be adapted to transmit an alarm triggering signal to the controller unit if a patient motion level is below a predefined motion level, as determined by the length of time without patient motion.

Abstract: The present invention relates to a helically coiled torsion spring for a torsion spring based automatic injection device, coiled in a longitudinal direction (X) and having a number of consecutive windings located between a distal winding having a distal end and a proximal winding having a proximal end. Each winding further has an outwardly pointing surface. At least one end of the torsion spring is abruptly cut to form a flat end surface with no bends and at least a number of the consecutive windings are coiled with a gap between the consecutive windings such that that the torsion spring apply an axial force when the distal end and the proximal end are moved axially against each other. The invention further relates to a torsion spring based automatic injection device for expelling settable doses of a liquid drug utilizing such torsion spring to urge the abruptly cut ends into proper engagement.

Abstract: The invention relates to hand-held, powered injection devices, for administering fluids, including vaccines, to animals. The invention further relates to methods of use of the powered injection device for vaccinating avian animals. Powered injection devices according to the instant disclosure are ergonomically friendly, and offer rapid and consistent dosing, particularly for avian animals.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a housing for such a device. The housing comprises an outer housing with a distal end and a cartridge holder with a proximal end, which, when the cartridge holder is attached to the outer housing, is inserted into the distal end of the outer housing. The outer housing is provided with a first fixture for axially constraining a further component part to the outer housing. When the cartridge holder is attached to the outer housing, the proximal end of the cartridge holder axially extends to the first fixture.

Abstract: A cartridge retainer comprises a sleeve having a distal end a proximal end and a longitudinal axis extending between the distal end and the proximal end. One or more tabs extend radially from the sleeve toward the longitudinal axis and are configured to radially deflect away from the longitudinal axis. One or more deformable members extend axially from the distal end of the sleeve toward the one or more tabs and are configured to deform in a longitudinal direction toward the distal end.

Abstract: A gasket is provided, which is laminated with an inert resin film and has a reduced sliding resistance and a higher liquid sealability. The gasket (10) is used for a medical syringe (30), and includes a main body (11) made of an elastic material and an inert resin film (12) provided on a surface of the main body (11). The gasket (10) has a short cylindrical shape, and includes a plurality of annular ribs (13, 14, 15) provided on an outer circumferential surface (20) thereof and each having a sliding contact portion (16) to be kept in sliding contact with an inner peripheral surface of a syringe barrel. The plurality of annular ribs are axially arranged from a distal end to a rear end of the gasket (10). The sliding contact portion (16) of a distal annular rib (13) has a width that is 1 to 25% of a length of the outer circumferential surface (20) of the cylindrical gasket as measured axially of the gasket.

Abstract: Various handheld medical dispensing configurations and methods including the following: Handheld medical dispensing system comprises a syringe, which has a plunger, releasably mounted to syringe actuation apparatus, the apparatus having an actuator configured such that it can move the plunger more than once to dispense a plurality of amounts of substance from the syringe and having a housing adapted for singled handed administration of an injection.

Abstract: The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a dose selector operable to set a dose by rotation relative to the housing, a number sleeve arranged within the housing, a drive sleeve which is rotationally constrained to the housing during dose setting and dose correcting and which is rotatable relative to the housing during dose dispensing, a piston rod coupled to the housing and to the drive sleeve a drive spring arranged between the housing and the number sleeve, and a ratchet operatively arranged between the drive sleeve and the number sleeve. According to the disclosure the ratchet comprises at least one clicker arm of one of the number sleeve and the drive sleeve and ratchet teeth of the other of the number sleeve and the drive sleeve.

Abstract: A method for assembling a drive spring, especially into a drug delivery device includes rotating a component part to which the drive spring is attached in a first direction, followed by a rotation of the component part in the opposite direction and followed by attachment of a rotational stop. Further, the disclosure includes a drug delivery device for selecting and dispensing a number of user variable doses of a medicament, which device comprises a pre-charged drive spring.

Abstract: A three-position plunger is provided including a sleeve having an opening at a distal end, a pre-load cavity proximal to and in communication with the opening, a first cavity proximal to and in communication with the pre-load cavity, a second cavity proximal to and in communication with the pre-load cavity, and at least one rib. The rib(s) is generally aligned with the first cavity. The plunger further includes an insert configured to be displaced from the pre-load cavity to the first cavity and from the first cavity to the second cavity. The insert is configured to provide support for the compression of the rib(s) when the insert is positioned in the first cavity.

Abstract: A nozzle cap (1) is provided, which is formed from a rubber composition containing a rubber component including a diene rubber and a non-diene rubber, wherein the diene rubber is present in a proportion of 20 to 70 parts by mass based on 100 parts by mass of the total of the rubbers in the rubber composition. The nozzle cap (1) has a moderate gas transmission property and, hence, can be quickly sterilized by EOG sterilization and steam sterilization, quickly removed of residues by deaeration, and quickly dried in a shorter period after the steam sterilization. In addition, the nozzle cap (1) is less liable to be loosened due to increase in internal pressure and compression set and detached from the nozzle, and has a reduced leaching substance amount before and after the sterilization.

Abstract: A fluid dispenser device having a body (1), and a dispenser head (2) provided with an orifice (3) and that is axially movable relative to the body (1). The body receives a reservoir (10) containing fluid, the reservoir has a hollow tube (11) having a proximal axial opening (12) closed by a stopper (20) adapted to slide in the tube (11). The dispenser head (2) includes a hollow cannula (4) connected at one end to the dispenser orifice (3), and provided at its other end with a perforating tip (5) having an opening (6) for perforating the stopper (20), the opening (6) defining a peripheral edge (7) extending around the opening (6) and includes a distal axial end and a proximal axial end, the distal axial end forming the distal axial end (59) of the perforating tip (5) arranged on the longitudinal central axis (A) of the cannula (4).

Abstract: The present invention provides a delivery device for intranasal administration of topical therapeutic agents to a desired site within a nasal cavity. The delivery device, in some embodiments, comprises a housing defining an interior and adapted to contain a supply of at least one therapeutic agent. The delivery device further includes a flexible connector, which is in fluid communication with the supply in the housing. A distributor, which is also integrally formed with the connector, is also provided. The distributor includes a proximal end that is in fluid communication with a distal end of the connector, and is adapted to receive the supply of the at least one therapeutic agent delivered by way of a conduit. The distributor further includes a distal end defining an outlet configured to diffuse the therapeutic agent when delivered to the treatment site.

Abstract: The present invention provides a 2-way air flow type dispenser for spraying powder and a powder sprayer including the same. The present invention adopts a 2-way air flow manner in which an air flow causing the powder to be sprayed and an air flow causing the powder to be transferred from a container to a spraying nozzle are separately formed, thereby enabling the smooth spraying of the powder.

Abstract: A nozzle and a method of generating an inhalable aerosol from a liquid solution or liquid suspension and a gas by operating the nozzle. A column-like aerosol plume is generated having fluid particles within a particle free sheath of gas, the aerosol plume being generated from a compressed gas interacting within the aerosolizing space with a fluid ejected along the central axis, and generates a Venturi effect entraining gas that flows over the convex outer nozzle surface that together with the particle free sheath keeps the circumferential edge and the outer nozzle surface free of particle deposition. An aerosol exit orifice diameter is at least 1.3 times larger than the fluid exit orifice diameter; and a converging annular pressurized gas channel extending at an acute gas flow angle of 10-30° with respect to a central axis.