Patents Issued in November 7, 2017
  • Patent number: 9809516
    Abstract: To provide a method for stably storing tetrafluoropropene filled in a container for e.g. storage or transportation, without occurrence of reaction such as polymerization. A method for storing tetrafluoropropene in a gaseous-liquid state composed of a gas phase and a liquid phase in a closed container, wherein the oxygen concentration (content) in the above gas phase is adjusted to at least 3 vol ppm and less than 3,000 vol ppm at a temperature of 25° C.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: November 7, 2017
    Assignee: ASAHI GLASS COMPANY, LIMITED
    Inventors: Masato Fukushima, Masaaki Tsuzaki, Maki Shigematsu
  • Patent number: 9809517
    Abstract: A process for decomposing formates in formate-containing compositions of matter comprises reacting formate-containing compositions of matter in the presence of at least one heterogeneous catalyst comprising lanthanum and at a temperature of from 80 to 180° C. and a pressure of from 0.1 to 60 bar, the formate-containing compositions of matter having a pH of from 6.5 to 10.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: November 7, 2017
    Assignee: BASF SE
    Inventors: Rolf Pinkos, Nicolas Marion, Helmut Kronemayer
  • Patent number: 9809518
    Abstract: Butanediol production processes are described herein. In some embodiments, the processes include contacting an allyl alcohol stream with a hydroformylation catalyst in the presence of a gas stream including carbon monoxide and hydrogen under hydroformylation conditions sufficient to form a hydroformylation product stream including a butanediol intermediate, wherein the allyl alcohol stream includes less than 98 wt. % allyl alcohol.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: November 7, 2017
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Daniel F. White, Roberto Alvarez, Beaven S. Mandimutsira
  • Patent number: 9809519
    Abstract: The invention relates to processes for oxygenate synthesis and homologation, to equipment and materials useful in such processes, and to the use of such oxygenate for producing olefin and polyolefin.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: November 7, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Monica D. Lotz, Paul F. Keusenkothen, Michael Salciccioli
  • Patent number: 9809520
    Abstract: Provided are methods for removing one or more components from a butanol based composition. The methods comprise providing a butanol based composition comprising one or more components, targeting at least one component or a combination thereof for reduction, and processing said butanol based composition such that the at least one targeted component is substantially removed. The butanol based composition can, for example, be bio-produced.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: November 7, 2017
    Assignee: Butamax Advanced Biofuels LLC
    Inventors: Cecilia Cheng, Ian David Dobson, Andrew John Hogben, Andrew Richard Lucy, John Glenn Sunley, Leslie William Bolton
  • Patent number: 9809521
    Abstract: The disclosure relates to cannabinoid derivative compounds, pharmaceutical compositions made thereof, and methods for treating various diseases and disorders including cancer.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: November 7, 2017
    Assignee: SUTTER WEST BAY HOSPITALS
    Inventors: Sean D. McAllister, Pierre-Yves Desprez, Anuradha Mahadevan
  • Patent number: 9809522
    Abstract: Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: November 7, 2017
    Assignee: SOUTH DAKOTA BOARD OF REGENTS
    Inventors: Alevtina Smirnova, Chris Lynde, Abu Md Numan-Al-Mobin, Rudresh Bommadihalli Rajappagowda
  • Patent number: 9809523
    Abstract: A process for the high-yield preparation of p-(R)calix[9-20]arenes.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 7, 2017
    Assignees: UNIVERSITE PARIS-SUD XI, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Vincent Germain Huc, Cyril Martini
  • Patent number: 9809524
    Abstract: The invention relates to a process for the preparation of a compound of formula I comprising a) reacting a compound of formula II in the presence of magnesium or an organometallic reagent of formula III R1M2X (III), wherein R1 is CI-C4alkyl; M2 is Li or Mg and X is halogen or absent; with a compound of formula IV CF3—C(O)—R2 (IV), wherein R2 is halogen, hydroxyl, CI-C4alkoxy, (di-CI-C4alkyl)amino, OC(O)CF3, phenoxy or OM1; wherein M1 is Lithium, Magnesium, Sodium or Potassium; to a compound of formula V, and b) reacting the compound of formula V with alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: November 7, 2017
    Assignee: Syngenta Participations
    Inventor: Helmars Smits
  • Patent number: 9809525
    Abstract: A method of making terephthalic acid via reductive coupling of two molecules of propiolic acid or propiolic acid derivatives is presented. The reductive coupling can be catalyzed by compounds comprising metals, and propiolic acid or propiolic acid derivatives can be produced from acetylene and carbon dioxide. At least 4 of the 8 carbons in the terephthalic acid are non-fossil-derived.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 7, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Jeffrey Charles Hayes, Hairong Guan, Dimitris Ioannis Collias
  • Patent number: 9809526
    Abstract: The invention relates to a process for dehydrating aqueous 3-hydroxypropionic acid to acrylic acid, wherein an aqueous mixture of 3-hydroxypropionic acid and oligomeric 3-hydroxypropionic acid is converted to acrylic acid in the liquid phase in a first step and aqueous acrylic acid is distilled out of the liquid phase, and the aqueous acrylic acid is separated by distillation into an acrylic acid-rich phase and a water-rich phase in a second step.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 7, 2017
    Assignee: BASF SE
    Inventors: Tim Blaschke, Ortmund Lang, Marta Zajaczkowski-Fischer, Marco Hartmann
  • Patent number: 9809527
    Abstract: Processes for the catalytic dehydration of hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity and without significant conversion to undesired side products, such as, acetaldehyde, propanoic acid, and acetic acid, are provided.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: November 7, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Jane Ellen Godlewski, Janette Villalobos, Dimitris Ioannis Collias, Juan Estaban Velasquez
  • Patent number: 9809528
    Abstract: The present disclosure is directed to methods and composition used in the preparation of alpha-hydroxy carboxylic acids and esters from higher sugars using a tandem catalyst system comprising retro-aldol catalysts and Lewis acid catalysts. In some embodiments, these alpha-hydroxy carboxylic acids may be prepared from pentoses and hexoses. The retro-aldol and Lewis catalysts may be characterized by their respective ability to catalyze a 1,2-carbon shift reaction and a 1,2-hydride shift reaction on an aldose or ketose substrate.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: November 7, 2017
    Assignee: California Institute of Technology
    Inventors: Marat Orazov, Mark E. Davis
  • Patent number: 9809529
    Abstract: A process comprising reacting a benzoic acid with a glycol ether in the presence of phosphoric acid to produce a glycol ether ester product having low color, low odor, and low VOC content.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: November 7, 2017
    Assignee: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: George J. Frycek, Felipe A. Donate, Edward D. Daugs, Rebecca J. Wachowicz, Jason L. Trumble
  • Patent number: 9809530
    Abstract: The present invention relates to a process for preparing alpha-hydroxycarboxylic esters from the alcoholysis of alpha-hydroxycarboxamides in the gas phase, characterized in that the conversion is effected in the presence of water.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: November 7, 2017
    Assignee: Evonik Roehm GmbH
    Inventors: Steffen Krill, Belaid Ait Aissa, Alexander May, Matthias Groemping
  • Patent number: 9809531
    Abstract: A method for producing a fatty acid ester through desulfurization of sulfur from a fatty acid ester using a catalyst, wherein the catalyst carries a catalyst metal on a support, (a) the catalyst contains as the catalyst metal one or more elements selected from the elements of group 9, group 10 and group 11 of the periodic table, (b) the total pore volume of the catalyst is 0.05 mL/g or more, and (c) the volume of pores with a pore size of 0.1 ?m or more and 500 ?m or less is 50% or more of the total pore volume of the catalyst. A desulfurization method using the desulfurization and a method for producing an alcohol through hydrogenation of the fatty acid ester obtained through the desulfurization are also provided.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: November 7, 2017
    Assignee: KAO CORPORATION
    Inventors: Nobuhiko Okada, Katsutoshi Yamamoto, Taichi Homma, Kazuyuki Harima
  • Patent number: 9809532
    Abstract: The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 11, 2012
    Date of Patent: November 7, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yitshak Francis, Ottavio Arancio, Mauro Fa
  • Patent number: 9809533
    Abstract: The purification method of an aldehyde compound of the present invention includes a step of neutralizing a reaction solution containing an aldehyde compound by adding water and a base compound to the reaction solution, and a step of distilling the neutralized reaction solution, in which the reaction solution is obtained by reacting a compound represented by the following Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, the phosphorus compound is represented by Formula (R1O)3P, and the base compound is at least one kind selected from among carbonate and hydrogen carbonate of metals of group I on the periodic table and carbonate and hydrogen carbonate of metals of group II on the periodic table.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: November 7, 2017
    Assignee: MITSUI CHEMICALS, INC.
    Inventors: Naoyuki Kakinuma, Masayuki Furuya, Michiharu Sakata, Koichi Tokunaga, Shigetoshi Kuma
  • Patent number: 9809534
    Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: November 7, 2017
    Assignee: AbbVie INC.
    Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
  • Patent number: 9809535
    Abstract: An alkyl mercaptan is prepared by reacting an aliphatic alcohol with hydrogen sulfide in the presence of a heterogeneous catalyst at varying temperatures.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: November 7, 2017
    Assignee: Evonik Degussa GmbH
    Inventors: Benjamin Fonfe, Stephan Kretz, Harald Jakob
  • Patent number: 9809536
    Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: November 7, 2017
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
  • Patent number: 9809537
    Abstract: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: November 7, 2017
    Assignees: Alectos Therapeutics Inc., Merck Sharp & Dohme Corp.
    Inventors: Ernest J. McEachern, Jianyu Sun, David J. Vocadlo, Yuanxi Zhou, Yongbao Zhu, Harold G. Selnick
  • Patent number: 9809538
    Abstract: Provided are modified natural compounds that are produced, at least in part, from (A) at least one epoxidized and/or maleated natural fatty acid, or epoxidized and/or maleated natural oil, and (B) at least one lactam having at least one hydroxyl functional group, wherein the lactam may be in a blend with one or more optional alcohol(s). Among other properties, the modified natural compounds may exhibit dispersibility or solubility characteristics in water and/or alcohols. The invention further provides a wide variety of compositions comprising the modified natural compounds.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: November 7, 2017
    Assignee: ISP INVESTMENTS LLC
    Inventors: Osama M. Musa, Ezat Khosravi
  • Patent number: 9809539
    Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: November 7, 2017
    Assignee: Shuttle Pharmaceuticals, LLC
    Inventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
  • Patent number: 9809540
    Abstract: A compound which is the hydrobromide salt of N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N?-(3-fluoro-2-methylphenyl)urea, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: November 7, 2017
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
    Inventors: Francis Dominic Sanderson, Sarah Mary Vallance
  • Patent number: 9809541
    Abstract: The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: November 7, 2017
    Assignee: Mirati Therapeutics, Inc.
    Inventors: Matthew Arnold Marx, Arkadii Vaisburg, James Gail Christensen, Robert Anthony Galemmo, Jr.
  • Patent number: 9809542
    Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides and/or fungicides. Moreover, the invention relates to selectively herbicidal compositions comprising, firstly, the spiroheterocyclically substituted tetramic acid derivatives and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising in particular spiroheterocyclically substituted tetramic acid derivatives through the addition of ammonium or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or fungicides and/or for preventing unwanted vegetation.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: November 7, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Reiner Fischer, Arnd Voerste, Isolde Häuser-Hahn, Stefan Lehr, Elmar Gatzweiler, Ulrich Görgens, Ines Heinemann
  • Patent number: 9809543
    Abstract: The present invention relates to a novel process for producing of 2,3-dichloro-5-(trichloromethyl)pyridine by using PCl as chlorinating agent at elevated temperature and pressure.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 7, 2017
    Assignee: CHEMINOVA A/S
    Inventor: Casper Stoubaek Andersen
  • Patent number: 9809544
    Abstract: The present invention relates to a compound, 1-[(5-chloro-2-pyridinyl)methyl]-3-{2,6-dichloro-4-[(2S)-1,1,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: November 7, 2017
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Kentaro Yashiro, Daisuke Wakamatsu, Tetsuji Saito
  • Patent number: 9809545
    Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: November 7, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Anthony Ogawa, Scott Edmondson, Mark Erion, Santhosh Neelamkavil, Zhuyan Guo, Rudrajit Mal, Jiafang He, Weiguo Liu, Ellen K. Vande Bunte
  • Patent number: 9809546
    Abstract: The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: November 7, 2017
    Assignee: Chungwha Chemical Synthesis & Biotech Co., Ltd.
    Inventors: Tzu-Chiang Lu, Chien-Yi Chen, Ching-Shuen Cheng, Chin-Cheng Mai
  • Patent number: 9809547
    Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: November 7, 2017
    Assignee: Janssen Pharmaceutica NV
    Inventors: Diego Fernando Domenico Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
  • Patent number: 9809548
    Abstract: Disclosed are novel polymorphic solvated and desolvated forms of the sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)phenyl]-benzenesulfonamide. One embodiment of the present invention is directed to a crystalline sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]benzenesulfonamide (hereinafter “Compound A-1,4-dioxane/water solvate”), wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising diffraction angles (°28), when measured using Cu Ku radiation, at about 4.0, 8.1, 10.1, 14.2, 16.2, 18.6, 20.3, 24.7, 25.0, and 26.5.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: November 7, 2017
    Assignee: ChemoCentryx, Inc.
    Inventors: Joanna Bis, David H. Igo
  • Patent number: 9809549
    Abstract: Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: November 7, 2017
    Assignee: Exelixis, Inc.
    Inventors: Adrian St. Clair Brown, Peter Lamb, William P. Gallagher
  • Patent number: 9809550
    Abstract: The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and/or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and/or caused by Micobacterium leprae.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: November 7, 2017
    Assignee: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.
    Inventors: Ana Lucia Almeida Ferreira, Ana Sofia Lopes, Augusto Eugenio Pardal Filipe, Pedro Filipe Eufrasio Pedroso, Susana Marques De Almeida Pecorelli, Carlos Caixado
  • Patent number: 9809551
    Abstract: Provided herein is a polymorphic form of Ivacaftor, namely APO-I, as well as processes for the preparation and pharmaceutical compositions of the same. Also, provided is a new solvate of Ivacaftor, processes for its preparation and use in the preparation of pure Ivacaftor.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: November 7, 2017
    Assignee: Apotex Inc.
    Inventors: Padiyath Mohammed Akbarali, Kintali Venkata Ramana, Heggadde Nanjunda Bhatta Shreenivasa Murthy, Sankaran Suresh Kumar, Ekkaluru Vijaya Bhaskar, Nechipadappu Sunil Kumar, Karad Manjunath
  • Patent number: 9809552
    Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: November 7, 2017
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Staehle, Christos Tsaklakidis, Manja Friese-Hamim, Birgitta Leuthner, Dirk Wienke
  • Patent number: 9809553
    Abstract: A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: November 7, 2017
    Assignee: LES LABORATOIRES SERVIER
    Inventors: Stéfano Chimenti, Christine Courchay, Aimee Dessinges, Françoise Gellibert, Bertrand Goument, Marc Konnert, Jean-Louis Peglion, Christophe Poitevin, Jean-Paul Vilaine, Nicole Villeneuve
  • Patent number: 9809554
    Abstract: The invention refers to a process for preparing ivabradine, in particular a process for preparing an ivabradine salt.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: November 7, 2017
    Assignee: OLON S.p.A.
    Inventors: Mara Sada, Faris Garis, Giorgio Bertolini
  • Patent number: 9809555
    Abstract: A crystalline form of mefenpyr-diethyl of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods and using the crystal to prepare stable agrochemical formulation. The invention also describes the use of various solvents towards the crystalline form preparation conditions.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: November 7, 2017
    Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED
    Inventor: James Timothy Bristow
  • Patent number: 9809556
    Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: November 7, 2017
    Assignee: Northwestern University
    Inventors: Richard B. Silverman, Yinan Zhang
  • Patent number: 9809557
    Abstract: The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: November 7, 2017
    Inventor: Claus Selch Larsen
  • Patent number: 9809558
    Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: November 7, 2017
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Peter Kumpalume, Oliver Schon, Christine Patricia Donahue, Ghotas Evindar, David I. Israel, David Paolella, Letian Kuai, Ninad V. Prabhu
  • Patent number: 9809559
    Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: November 7, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
  • Patent number: 9809560
    Abstract: Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: November 7, 2017
    Assignee: Albert Einstein College of Medicine, Inc.
    Inventors: Peng Wu, David Soriano del Amo, Wei Wang, Florence L. Marlow
  • Patent number: 9809561
    Abstract: The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: November 7, 2017
    Assignees: MERCK SHARP & DOHME CORP., LYCERA CORPORATION
    Inventors: Thomas D. Aicher, Chad A. VanHuis, William D. Thomas, John K. MacLean, Brian M. Andresen, Kenneth J. Barr, Corey E. Bienstock, Neville J. Anthony, Matthew Daniels, Kun Liu, Yuan Liu, Catherine M. White, Blair T. Lapointe, Nunzio Sciammetta, Vladimir Simov
  • Patent number: 9809562
    Abstract: The invention relates to compounds in the treatment or prevention of disorders associated with Lamin A and/or Lamin C depletion or LMNA mutations, such as laminopathy, premature ageing disorders, normal ageing and cancer (such as a cancer characterized by low levels of LMNA expression).
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: November 7, 2017
    Assignees: CAMBRIDGE ENTERPRISE LIMITED, THE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Delphine Laurence Daniele Larrieu, Raphaël Joël Rodriguez, Sébastien Frédéric Stéphane Britton, Stephen Philip Jackson
  • Patent number: 9809563
    Abstract: An object of the present invention is to provide an anti-prion compound that has high crystallinity and is highly stable in the crystalline form and to provide a medicament for preventing, ameliorating or treating a prion disease.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: November 7, 2017
    Assignee: GIFU University
    Inventor: Kazuo Kuwata
  • Patent number: 9809564
    Abstract: The present invention is related to a thermal extract of a plant material and methods of extraction thereof. The method of producing a thermal extract from a plant starting material by means of a thermal extraction of the starting material wherein the improvement consists in requiring smaller amounts of costly and/or toxic organic solvents for the extraction and partitioning steps.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: November 7, 2017
    Assignee: Pharmatherm Chemicals, Inc.
    Inventors: David Boulard, Robert G. Graham, Barry A. Freel
  • Patent number: 9809565
    Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: November 7, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ulla Letinois, Thomas Netscher, Stephan Ackermann