Patents Issued in November 7, 2017
-
Patent number: 9809516Abstract: To provide a method for stably storing tetrafluoropropene filled in a container for e.g. storage or transportation, without occurrence of reaction such as polymerization. A method for storing tetrafluoropropene in a gaseous-liquid state composed of a gas phase and a liquid phase in a closed container, wherein the oxygen concentration (content) in the above gas phase is adjusted to at least 3 vol ppm and less than 3,000 vol ppm at a temperature of 25° C.Type: GrantFiled: April 5, 2017Date of Patent: November 7, 2017Assignee: ASAHI GLASS COMPANY, LIMITEDInventors: Masato Fukushima, Masaaki Tsuzaki, Maki Shigematsu
-
Patent number: 9809517Abstract: A process for decomposing formates in formate-containing compositions of matter comprises reacting formate-containing compositions of matter in the presence of at least one heterogeneous catalyst comprising lanthanum and at a temperature of from 80 to 180° C. and a pressure of from 0.1 to 60 bar, the formate-containing compositions of matter having a pH of from 6.5 to 10.Type: GrantFiled: March 5, 2015Date of Patent: November 7, 2017Assignee: BASF SEInventors: Rolf Pinkos, Nicolas Marion, Helmut Kronemayer
-
Patent number: 9809518Abstract: Butanediol production processes are described herein. In some embodiments, the processes include contacting an allyl alcohol stream with a hydroformylation catalyst in the presence of a gas stream including carbon monoxide and hydrogen under hydroformylation conditions sufficient to form a hydroformylation product stream including a butanediol intermediate, wherein the allyl alcohol stream includes less than 98 wt. % allyl alcohol.Type: GrantFiled: November 16, 2016Date of Patent: November 7, 2017Assignee: Lyondell Chemical Technology, L.P.Inventors: Daniel F. White, Roberto Alvarez, Beaven S. Mandimutsira
-
Patent number: 9809519Abstract: The invention relates to processes for oxygenate synthesis and homologation, to equipment and materials useful in such processes, and to the use of such oxygenate for producing olefin and polyolefin.Type: GrantFiled: April 26, 2017Date of Patent: November 7, 2017Assignee: ExxonMobil Chemical Patents Inc.Inventors: Monica D. Lotz, Paul F. Keusenkothen, Michael Salciccioli
-
Patent number: 9809520Abstract: Provided are methods for removing one or more components from a butanol based composition. The methods comprise providing a butanol based composition comprising one or more components, targeting at least one component or a combination thereof for reduction, and processing said butanol based composition such that the at least one targeted component is substantially removed. The butanol based composition can, for example, be bio-produced.Type: GrantFiled: July 26, 2013Date of Patent: November 7, 2017Assignee: Butamax Advanced Biofuels LLCInventors: Cecilia Cheng, Ian David Dobson, Andrew John Hogben, Andrew Richard Lucy, John Glenn Sunley, Leslie William Bolton
-
Patent number: 9809521Abstract: The disclosure relates to cannabinoid derivative compounds, pharmaceutical compositions made thereof, and methods for treating various diseases and disorders including cancer.Type: GrantFiled: January 25, 2016Date of Patent: November 7, 2017Assignee: SUTTER WEST BAY HOSPITALSInventors: Sean D. McAllister, Pierre-Yves Desprez, Anuradha Mahadevan
-
Patent number: 9809522Abstract: Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.Type: GrantFiled: September 12, 2016Date of Patent: November 7, 2017Assignee: SOUTH DAKOTA BOARD OF REGENTSInventors: Alevtina Smirnova, Chris Lynde, Abu Md Numan-Al-Mobin, Rudresh Bommadihalli Rajappagowda
-
Patent number: 9809523Abstract: A process for the high-yield preparation of p-(R)calix[9-20]arenes.Type: GrantFiled: February 27, 2015Date of Patent: November 7, 2017Assignees: UNIVERSITE PARIS-SUD XI, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Vincent Germain Huc, Cyril Martini
-
Patent number: 9809524Abstract: The invention relates to a process for the preparation of a compound of formula I comprising a) reacting a compound of formula II in the presence of magnesium or an organometallic reagent of formula III R1M2X (III), wherein R1 is CI-C4alkyl; M2 is Li or Mg and X is halogen or absent; with a compound of formula IV CF3—C(O)—R2 (IV), wherein R2 is halogen, hydroxyl, CI-C4alkoxy, (di-CI-C4alkyl)amino, OC(O)CF3, phenoxy or OM1; wherein M1 is Lithium, Magnesium, Sodium or Potassium; to a compound of formula V, and b) reacting the compound of formula V with alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I.Type: GrantFiled: October 8, 2015Date of Patent: November 7, 2017Assignee: Syngenta ParticipationsInventor: Helmars Smits
-
Patent number: 9809525Abstract: A method of making terephthalic acid via reductive coupling of two molecules of propiolic acid or propiolic acid derivatives is presented. The reductive coupling can be catalyzed by compounds comprising metals, and propiolic acid or propiolic acid derivatives can be produced from acetylene and carbon dioxide. At least 4 of the 8 carbons in the terephthalic acid are non-fossil-derived.Type: GrantFiled: March 11, 2016Date of Patent: November 7, 2017Assignee: The Procter & Gamble CompanyInventors: Jeffrey Charles Hayes, Hairong Guan, Dimitris Ioannis Collias
-
Patent number: 9809526Abstract: The invention relates to a process for dehydrating aqueous 3-hydroxypropionic acid to acrylic acid, wherein an aqueous mixture of 3-hydroxypropionic acid and oligomeric 3-hydroxypropionic acid is converted to acrylic acid in the liquid phase in a first step and aqueous acrylic acid is distilled out of the liquid phase, and the aqueous acrylic acid is separated by distillation into an acrylic acid-rich phase and a water-rich phase in a second step.Type: GrantFiled: May 13, 2015Date of Patent: November 7, 2017Assignee: BASF SEInventors: Tim Blaschke, Ortmund Lang, Marta Zajaczkowski-Fischer, Marco Hartmann
-
Patent number: 9809527Abstract: Processes for the catalytic dehydration of hydroxypropionic acid, hydroxypropionic acid derivatives, or mixtures thereof to acrylic acid, acrylic acid derivatives, or mixtures thereof with high yield and selectivity and without significant conversion to undesired side products, such as, acetaldehyde, propanoic acid, and acetic acid, are provided.Type: GrantFiled: October 10, 2014Date of Patent: November 7, 2017Assignee: The Procter & Gamble CompanyInventors: Jane Ellen Godlewski, Janette Villalobos, Dimitris Ioannis Collias, Juan Estaban Velasquez
-
Patent number: 9809528Abstract: The present disclosure is directed to methods and composition used in the preparation of alpha-hydroxy carboxylic acids and esters from higher sugars using a tandem catalyst system comprising retro-aldol catalysts and Lewis acid catalysts. In some embodiments, these alpha-hydroxy carboxylic acids may be prepared from pentoses and hexoses. The retro-aldol and Lewis catalysts may be characterized by their respective ability to catalyze a 1,2-carbon shift reaction and a 1,2-hydride shift reaction on an aldose or ketose substrate.Type: GrantFiled: July 12, 2016Date of Patent: November 7, 2017Assignee: California Institute of TechnologyInventors: Marat Orazov, Mark E. Davis
-
Patent number: 9809529Abstract: A process comprising reacting a benzoic acid with a glycol ether in the presence of phosphoric acid to produce a glycol ether ester product having low color, low odor, and low VOC content.Type: GrantFiled: June 18, 2015Date of Patent: November 7, 2017Assignee: DOW GLOBAL TECHNOLOGIES LLCInventors: George J. Frycek, Felipe A. Donate, Edward D. Daugs, Rebecca J. Wachowicz, Jason L. Trumble
-
Patent number: 9809530Abstract: The present invention relates to a process for preparing alpha-hydroxycarboxylic esters from the alcoholysis of alpha-hydroxycarboxamides in the gas phase, characterized in that the conversion is effected in the presence of water.Type: GrantFiled: July 23, 2015Date of Patent: November 7, 2017Assignee: Evonik Roehm GmbHInventors: Steffen Krill, Belaid Ait Aissa, Alexander May, Matthias Groemping
-
Patent number: 9809531Abstract: A method for producing a fatty acid ester through desulfurization of sulfur from a fatty acid ester using a catalyst, wherein the catalyst carries a catalyst metal on a support, (a) the catalyst contains as the catalyst metal one or more elements selected from the elements of group 9, group 10 and group 11 of the periodic table, (b) the total pore volume of the catalyst is 0.05 mL/g or more, and (c) the volume of pores with a pore size of 0.1 ?m or more and 500 ?m or less is 50% or more of the total pore volume of the catalyst. A desulfurization method using the desulfurization and a method for producing an alcohol through hydrogenation of the fatty acid ester obtained through the desulfurization are also provided.Type: GrantFiled: November 17, 2015Date of Patent: November 7, 2017Assignee: KAO CORPORATIONInventors: Nobuhiko Okada, Katsutoshi Yamamoto, Taichi Homma, Kazuyuki Harima
-
Patent number: 9809532Abstract: The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 11, 2012Date of Patent: November 7, 2017Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Yitshak Francis, Ottavio Arancio, Mauro Fa
-
Patent number: 9809533Abstract: The purification method of an aldehyde compound of the present invention includes a step of neutralizing a reaction solution containing an aldehyde compound by adding water and a base compound to the reaction solution, and a step of distilling the neutralized reaction solution, in which the reaction solution is obtained by reacting a compound represented by the following Formula (a1) or (a2) with hydrogen and carbon monoxide in the presence of a metal compound of groups 8 to 10 and a phosphorus compound, the phosphorus compound is represented by Formula (R1O)3P, and the base compound is at least one kind selected from among carbonate and hydrogen carbonate of metals of group I on the periodic table and carbonate and hydrogen carbonate of metals of group II on the periodic table.Type: GrantFiled: November 8, 2013Date of Patent: November 7, 2017Assignee: MITSUI CHEMICALS, INC.Inventors: Naoyuki Kakinuma, Masayuki Furuya, Michiharu Sakata, Koichi Tokunaga, Shigetoshi Kuma
-
Patent number: 9809534Abstract: The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.Type: GrantFiled: July 17, 2015Date of Patent: November 7, 2017Assignee: AbbVie INC.Inventors: Kirill A. Lukin, Jianzhang Mei, David R. Hill, Michael J. Abrahamson
-
Patent number: 9809535Abstract: An alkyl mercaptan is prepared by reacting an aliphatic alcohol with hydrogen sulfide in the presence of a heterogeneous catalyst at varying temperatures.Type: GrantFiled: December 18, 2015Date of Patent: November 7, 2017Assignee: Evonik Degussa GmbHInventors: Benjamin Fonfe, Stephan Kretz, Harald Jakob
-
Patent number: 9809536Abstract: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions.Type: GrantFiled: October 22, 2012Date of Patent: November 7, 2017Assignee: MERCK SHARP & DOHME CORP.Inventors: John Y. L. Chung, Kevin Campos, Edward Cleator, Robert F. Dunn, Andrew Gibson, R Scott Hoerrner, Stephen Keen, Dave Lieberman, Zhuqing Liu, Joseph Lynch, Kevin M. Maloney, Feng Xu, Nobuyoshi Yasuda, Naoki Yoshikawa, Yong-Li Zhong
-
Patent number: 9809537Abstract: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.Type: GrantFiled: August 29, 2013Date of Patent: November 7, 2017Assignees: Alectos Therapeutics Inc., Merck Sharp & Dohme Corp.Inventors: Ernest J. McEachern, Jianyu Sun, David J. Vocadlo, Yuanxi Zhou, Yongbao Zhu, Harold G. Selnick
-
Patent number: 9809538Abstract: Provided are modified natural compounds that are produced, at least in part, from (A) at least one epoxidized and/or maleated natural fatty acid, or epoxidized and/or maleated natural oil, and (B) at least one lactam having at least one hydroxyl functional group, wherein the lactam may be in a blend with one or more optional alcohol(s). Among other properties, the modified natural compounds may exhibit dispersibility or solubility characteristics in water and/or alcohols. The invention further provides a wide variety of compositions comprising the modified natural compounds.Type: GrantFiled: July 25, 2011Date of Patent: November 7, 2017Assignee: ISP INVESTMENTS LLCInventors: Osama M. Musa, Ezat Khosravi
-
Patent number: 9809539Abstract: Dual function compounds are provided that may be inhibitors of histone deacetylase (HDAC) and activators of ataxia telangiectasia mutated (ATM). Pharmaceutical compositions and methods of use are also provided that utilize such compounds.Type: GrantFiled: March 3, 2015Date of Patent: November 7, 2017Assignee: Shuttle Pharmaceuticals, LLCInventors: Scott Grindrod, Mira Jung, Milton Brown, Anatoly Dritschilo
-
Patent number: 9809540Abstract: A compound which is the hydrobromide salt of N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N?-(3-fluoro-2-methylphenyl)urea, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments.Type: GrantFiled: November 11, 2014Date of Patent: November 7, 2017Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITEDInventors: Francis Dominic Sanderson, Sarah Mary Vallance
-
Patent number: 9809541Abstract: The present invention relates to compounds that inhibit LSD1 activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.Type: GrantFiled: November 3, 2016Date of Patent: November 7, 2017Assignee: Mirati Therapeutics, Inc.Inventors: Matthew Arnold Marx, Arkadii Vaisburg, James Gail Christensen, Robert Anthony Galemmo, Jr.
-
Patent number: 9809542Abstract: The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides and/or fungicides. Moreover, the invention relates to selectively herbicidal compositions comprising, firstly, the spiroheterocyclically substituted tetramic acid derivatives and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising in particular spiroheterocyclically substituted tetramic acid derivatives through the addition of ammonium or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or fungicides and/or for preventing unwanted vegetation.Type: GrantFiled: February 10, 2011Date of Patent: November 7, 2017Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Reiner Fischer, Arnd Voerste, Isolde Häuser-Hahn, Stefan Lehr, Elmar Gatzweiler, Ulrich Görgens, Ines Heinemann
-
Patent number: 9809543Abstract: The present invention relates to a novel process for producing of 2,3-dichloro-5-(trichloromethyl)pyridine by using PCl as chlorinating agent at elevated temperature and pressure.Type: GrantFiled: June 13, 2014Date of Patent: November 7, 2017Assignee: CHEMINOVA A/SInventor: Casper Stoubaek Andersen
-
Patent number: 9809544Abstract: The present invention relates to a compound, 1-[(5-chloro-2-pyridinyl)methyl]-3-{2,6-dichloro-4-[(2S)-1,1,1-trifluoro-2-hydroxy-2-propanyl]phenyl}urea, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 23, 2015Date of Patent: November 7, 2017Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kentaro Yashiro, Daisuke Wakamatsu, Tetsuji Saito
-
Patent number: 9809545Abstract: The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes.Type: GrantFiled: March 21, 2014Date of Patent: November 7, 2017Assignee: Merck Sharp & Dohme Corp.Inventors: Anthony Ogawa, Scott Edmondson, Mark Erion, Santhosh Neelamkavil, Zhuyan Guo, Rudrajit Mal, Jiafang He, Weiguo Liu, Ellen K. Vande Bunte
-
Patent number: 9809546Abstract: The present invention provides a low-toxic and high-recovery industrial process for synthesizing an optically active diamine derivative represented by formula (D), the process comprising the steps of: (a) mixing a compound represented by formula (A) and a compound represented by formula (C) in organic solvents and secondary amine; (b) reaction under heating; (c) cooling and adding water to the mixed solution, allowing it to crystallize to obtain the compound represented by formula (D).Type: GrantFiled: May 12, 2016Date of Patent: November 7, 2017Assignee: Chungwha Chemical Synthesis & Biotech Co., Ltd.Inventors: Tzu-Chiang Lu, Chien-Yi Chen, Ching-Shuen Cheng, Chin-Cheng Mai
-
Patent number: 9809547Abstract: The present invention is directed to novel processes for the preparation of histamine H3 receptor modulators, in the treatment of for example, cognitive disorders, sleep disorders and/or psychiatric disorders.Type: GrantFiled: November 11, 2016Date of Patent: November 7, 2017Assignee: Janssen Pharmaceutica NVInventors: Diego Fernando Domenico Broggini, Vit Lellek, Susanne Lochner, Neelakandha S. Mani, Adrian Maurer, Daniel J. Pippel, Lana K. Young
-
Patent number: 9809548Abstract: Disclosed are novel polymorphic solvated and desolvated forms of the sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)phenyl]-benzenesulfonamide. One embodiment of the present invention is directed to a crystalline sodium salt of 4-tert-butyl-N-[4-chloro-2-(1-oxy-pyridine-4-carbonyl)-phenyl]benzenesulfonamide (hereinafter “Compound A-1,4-dioxane/water solvate”), wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising diffraction angles (°28), when measured using Cu Ku radiation, at about 4.0, 8.1, 10.1, 14.2, 16.2, 18.6, 20.3, 24.7, 25.0, and 26.5.Type: GrantFiled: October 10, 2016Date of Patent: November 7, 2017Assignee: ChemoCentryx, Inc.Inventors: Joanna Bis, David H. Igo
-
Patent number: 9809549Abstract: Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)-cyclopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N?-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide.Type: GrantFiled: July 25, 2014Date of Patent: November 7, 2017Assignee: Exelixis, Inc.Inventors: Adrian St. Clair Brown, Peter Lamb, William P. Gallagher
-
Patent number: 9809550Abstract: The invention provides quinolyl-hydrazones of Formula I, or pharmaceutically acceptable salts, esters, solvates, isomers and prodrugs thereof as well as pharmaceutical compositions containing these compounds for use in the prophylactic and/or therapeutic treatment of tuberculosis and related diseases, such as, diseases caused by nontuberculous mycobacteria and/or caused by Micobacterium leprae.Type: GrantFiled: November 20, 2013Date of Patent: November 7, 2017Assignee: TECNIMEDE SOCIEDADE TECNICO-MEDICINAL S.A.Inventors: Ana Lucia Almeida Ferreira, Ana Sofia Lopes, Augusto Eugenio Pardal Filipe, Pedro Filipe Eufrasio Pedroso, Susana Marques De Almeida Pecorelli, Carlos Caixado
-
Patent number: 9809551Abstract: Provided herein is a polymorphic form of Ivacaftor, namely APO-I, as well as processes for the preparation and pharmaceutical compositions of the same. Also, provided is a new solvate of Ivacaftor, processes for its preparation and use in the preparation of pure Ivacaftor.Type: GrantFiled: November 13, 2014Date of Patent: November 7, 2017Assignee: Apotex Inc.Inventors: Padiyath Mohammed Akbarali, Kintali Venkata Ramana, Heggadde Nanjunda Bhatta Shreenivasa Murthy, Sankaran Suresh Kumar, Ekkaluru Vijaya Bhaskar, Nechipadappu Sunil Kumar, Karad Manjunath
-
Patent number: 9809552Abstract: Compounds of the formula I in which R, X1, X2, X3, X4, R1, R2 and q have the meanings indicated in Claim 1, are inhibitors of fatty acid synthase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.Type: GrantFiled: February 24, 2014Date of Patent: November 7, 2017Assignee: MERCK PATENT GMBHInventors: Wolfgang Staehle, Christos Tsaklakidis, Manja Friese-Hamim, Birgitta Leuthner, Dirk Wienke
-
Patent number: 9809553Abstract: A compound of formula (I): wherein the substituents are as defined in the description. Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.Type: GrantFiled: February 20, 2015Date of Patent: November 7, 2017Assignee: LES LABORATOIRES SERVIERInventors: Stéfano Chimenti, Christine Courchay, Aimee Dessinges, Françoise Gellibert, Bertrand Goument, Marc Konnert, Jean-Louis Peglion, Christophe Poitevin, Jean-Paul Vilaine, Nicole Villeneuve
-
Patent number: 9809554Abstract: The invention refers to a process for preparing ivabradine, in particular a process for preparing an ivabradine salt.Type: GrantFiled: May 19, 2014Date of Patent: November 7, 2017Assignee: OLON S.p.A.Inventors: Mara Sada, Faris Garis, Giorgio Bertolini
-
Patent number: 9809555Abstract: A crystalline form of mefenpyr-diethyl of formula (I), the crystal preparation process, the analyses of the crystal through various analytical methods and using the crystal to prepare stable agrochemical formulation. The invention also describes the use of various solvents towards the crystalline form preparation conditions.Type: GrantFiled: December 2, 2015Date of Patent: November 7, 2017Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITEDInventor: James Timothy Bristow
-
Patent number: 9809556Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.Type: GrantFiled: September 28, 2015Date of Patent: November 7, 2017Assignee: Northwestern UniversityInventors: Richard B. Silverman, Yinan Zhang
-
Patent number: 9809557Abstract: The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.Type: GrantFiled: October 31, 2012Date of Patent: November 7, 2017Inventor: Claus Selch Larsen
-
Patent number: 9809558Abstract: Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum albumin (HSA) and fusion proteins thereof. Methods for extending the half-life of therapeutic agents are also presented, particularly therapeutic peptide agents and small molecules, such as by conjugation of compounds described herein to the therapeutic peptide or small molecule, which upon administration, binds to HSA, thereby providing a prolonged release of the therapeutic agent.Type: GrantFiled: October 1, 2014Date of Patent: November 7, 2017Assignee: GlaxoSmithKline Intellectual Property Development LimitedInventors: Peter Kumpalume, Oliver Schon, Christine Patricia Donahue, Ghotas Evindar, David I. Israel, David Paolella, Letian Kuai, Ninad V. Prabhu
-
Patent number: 9809559Abstract: The present invention relates to stable novel salt forms of N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide that are suitable for the preparation of pharmaceutical formulations thereof, and their therapeutic use.Type: GrantFiled: August 8, 2016Date of Patent: November 7, 2017Assignee: GILEAD SCIENCES, INC.Inventors: Brandon H. Brown, Ernest A. Carra, Jeffrey N. Hemenway, Henry Morrison, Troy Reynolds, Bing Shi, Dimitrios Stefanidis, Fang Wang, Matthew Robert Warr, James Andrew Whitney, Yan Xin
-
Patent number: 9809560Abstract: Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.Type: GrantFiled: August 5, 2011Date of Patent: November 7, 2017Assignee: Albert Einstein College of Medicine, Inc.Inventors: Peng Wu, David Soriano del Amo, Wei Wang, Florence L. Marlow
-
Patent number: 9809561Abstract: The invention provides certain bicylic heterocyclic compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R2, R3, R4, and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.Type: GrantFiled: December 19, 2014Date of Patent: November 7, 2017Assignees: MERCK SHARP & DOHME CORP., LYCERA CORPORATIONInventors: Thomas D. Aicher, Chad A. VanHuis, William D. Thomas, John K. MacLean, Brian M. Andresen, Kenneth J. Barr, Corey E. Bienstock, Neville J. Anthony, Matthew Daniels, Kun Liu, Yuan Liu, Catherine M. White, Blair T. Lapointe, Nunzio Sciammetta, Vladimir Simov
-
Patent number: 9809562Abstract: The invention relates to compounds in the treatment or prevention of disorders associated with Lamin A and/or Lamin C depletion or LMNA mutations, such as laminopathy, premature ageing disorders, normal ageing and cancer (such as a cancer characterized by low levels of LMNA expression).Type: GrantFiled: April 2, 2015Date of Patent: November 7, 2017Assignees: CAMBRIDGE ENTERPRISE LIMITED, THE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Delphine Laurence Daniele Larrieu, Raphaël Joël Rodriguez, Sébastien Frédéric Stéphane Britton, Stephen Philip Jackson
-
Patent number: 9809563Abstract: An object of the present invention is to provide an anti-prion compound that has high crystallinity and is highly stable in the crystalline form and to provide a medicament for preventing, ameliorating or treating a prion disease.Type: GrantFiled: February 3, 2015Date of Patent: November 7, 2017Assignee: GIFU UniversityInventor: Kazuo Kuwata
-
Patent number: 9809564Abstract: The present invention is related to a thermal extract of a plant material and methods of extraction thereof. The method of producing a thermal extract from a plant starting material by means of a thermal extraction of the starting material wherein the improvement consists in requiring smaller amounts of costly and/or toxic organic solvents for the extraction and partitioning steps.Type: GrantFiled: July 29, 2015Date of Patent: November 7, 2017Assignee: Pharmatherm Chemicals, Inc.Inventors: David Boulard, Robert G. Graham, Barry A. Freel
-
Patent number: 9809565Abstract: The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one urea or thiourea.Type: GrantFiled: July 3, 2014Date of Patent: November 7, 2017Assignee: DSM IP ASSETS B.V.Inventors: Ulla Letinois, Thomas Netscher, Stephan Ackermann