Patents Issued in November 7, 2017
  • Patent number: 9809767
    Abstract: The invention relates to mixtures comprising molecular hydrogen, hydrocarbons, and nitrogen oxides; to processes for removing at least a portion of the nitrogen oxides therefrom; to equipment useful in such processes; and to the use of such hydrocarbons for, e.g., chemical manufacturing.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: November 7, 2017
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Larry L. Iaccino, Michael Moran, Silvio Carrettin
  • Patent number: 9809768
    Abstract: A device for producing fuel gas from materials of organic and/or inorganic origin, comprising filling chamber connected to at least one supply auger conveyor for supplying material from the filling chamber into a reactor comprising at least two heated gasification augers. The invention consists in the fact that each horizontal row of gasification augers is formed by a gasification body, the casing of which has a closed oval cross-section formed by an upper base, a lower base, and convex side walls each with circular arc profiles, wherein each gasifying body contains at least two gasification augers arranged side by side and mutually partially separated by longitudinal partitions that form half-grooves for gasifying augers. The device is provided with at least one electrical heater. The filling chamber is hermetically sealed.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: November 7, 2017
    Inventor: Lubor Jancok
  • Patent number: 9809769
    Abstract: A fluidized bed biogasifier is provided for gasifying biosolids. The biogasifier includes a reactor vessel and a feeder for feeding biosolids into the reactor vessel at a desired feed rate during steady-state operation of the biogasifier. A fluidized bed in the base of the reactor vessel has a cross-sectional area that is proportional to at least the fuel feed rate such that the superficial velocity of gas is in the range of 0.1 m/s (0.33 ft/s) to 3 m/s (9.84 ft/s). In a method for gasifying biosolids, biosolids are fed into a fluidized bed reactor. Oxidant gases are applied to the fluidized bed reactor to produce a superficial velocity of producer gas in the range of 0.1 m/s (0.33 ft/s) to 3 m/s (9.84 ft/s). The biosolids are heated inside the fluidized bed reactor to a temperature range between 900° F. (482.2° C.) and 1700° F. (926.7° C.) in an oxygen-starved environment having a sub-stoichiometric oxygen level, whereby the biosolids are gasified.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: November 7, 2017
    Assignee: Aries Gasification, LLC
    Inventors: Douglas R. Bull, Ross M. Patten, Paul Cairney, Gerald M. Cox, William P. Jepson
  • Patent number: 9809770
    Abstract: The present disclosure provides a method for preparing hydrogen-rich gas by solid organics. For example, solid organic raw materials are heated in a pyrolysis reaction device to perform pyrolysis reaction, and gaseous product generated from the pyrolysis reaction performs gasification with steam in a moving bed gasification reaction device to generate hydrogen-rich product. The present disclosure also provides a system for preparing hydrogen-rich gas by solid organics, and the system may include a solid heat carrier grading-dedusting device; a pyrolysis reaction device; a moving bed gasification reaction device; and a riser and combustion reactor. The present disclosure may operate at atmospheric pressure, and the technology is simple and suitable for the gasification and co-gasification of various high-volatile solid organics, such as raw materials containing a relatively large amount of moisture, mineral substance, and sulfur content.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: November 7, 2017
    Assignees: ECO ENVIRONMENTAL ENERGY RESEARCH INSTITUTE LIMITED, DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Shaoping Xu, Yahui Xiao, Chao Wang, Guangyong Wang, Tursun Yalkunjan, Kam Shing Siu, Bin Xu, Hiu Ying Connie Chow
  • Patent number: 9809771
    Abstract: A carbonaceous substance dry powder gasification device and method, the device comprising from bottom to top a lower cooling and purification section (1), a gasification reaction section (2), a cooling reaction section (3) and an upper cooling and purification section (4); an initial cooling device is disposed at the connection between the cooling reaction section and the gasification reaction section; and a plurality of nozzles are circumferentially arranged in the gasification reaction section.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: November 7, 2017
    Assignee: ChangZheng Engineering Co., Ltd.
    Inventors: Congbin Jiang, Wei Xin, Honghai Li, Ruiheng Gao, Yongjin Chen, Xiaofei Li, Yan Zhang, Li Zhang
  • Patent number: 9809772
    Abstract: Tar-like components can be removed from gas streams resulting from gasification of coal, waste or biomass by contacting the gas with a liquid organic aryl polysiloxane. The polysiloxane preferably contains alkyl groups and aryl groups, and is in particular a polymethyl polyphenyl polysiloxane. The gas comprises one or more of hydrogen, carbon monoxide, carbon dioxide, and methane.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: November 7, 2017
    Assignee: Stichting Energieonderzoek Centrum Nederland
    Inventors: Berend Joost Vreugdenhil, Alexander Bos, Lucas Pancratius Johannes Bleijendaal
  • Patent number: 9809773
    Abstract: A methodology for the removal of the harmful components of ash from urban/industrial wastes and sludges from the sewage treatment plants is invented. The harmful components are alkaline metals, chlorine, sulphur, zinc, lead, and chromium. They are removed before the thermochemical conversion and therefore the corrosion problems, scaling/deposition, ash agglomeration, dioxin and furan emissions, alkaline metal, chlorine, sulphur emissions are minimized if not diminished. The emissions of heavy metals such as zinc, lead, copper, and chromium are reduced. The removal is achieved with prepyrolysis/pregasification at 250-320° C. for 5 min to 2 h of urban/industrial wastes and sludges from the sewage treatment plants. Then the prepyrolyzed/pregasified sample is washed with a 0.5%-5% weight basis aqueous calcium acetate and/or magnesium acetate and/or aluminum acetate solution.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: November 7, 2017
    Assignee: Thermorefinery Technologies LLC
    Inventor: Emmanouil Koukios
  • Patent number: 9809774
    Abstract: A process for separating a solid having two or more components, at least one of which is lyophobic and at least one of which is lyophilic. The process comprises, in a single step, comminuting a mixture of the solid in a first liquid to which one of the components is lyophilic and to which the other component is lyophobic and in a second liquid which is immiscible with the first liquid and which will wet the lyophobic component to form agglomerates or floes of the lyophobic component and the second liquid in a mill having positive transport capability such that the mill causes the mixture to be transported therethrough. The second liquid comprises a bio-oil, bio-diesel or combination thereof. The agglomerates are then separated from the mixture. This process may be used for beneficiating a coal containing ash.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: November 7, 2017
    Assignee: Converde Energy Inc.
    Inventors: Olev Trass, Michael David McLaren
  • Patent number: 9809775
    Abstract: An organic fuel additive for improving the combustion of a bioenergy solid fuel product, the organic fuel additive comprising a mixture of combustible organic fines and a polymer material, wherein the polymer material encapsulates the combustible organic fines in solid form, and methods of making and using the same.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: November 7, 2017
    Assignee: IHB TECHNOLOGIES, INC.
    Inventors: Hans E. Iverson, Kerstin K. Iverson
  • Patent number: 9809776
    Abstract: A mould release lubricant comprises of palm-derived base fluid and a specialty additive of satisfactory mould release and lubrication properties such as a tackifier, and if deemed necessary, other additives to improve the lubrication of the mould, is disclosed. The lubricant comprises at least one vegetable base fluid and/or its derivatives having good low temperature fluidity property, and at least one tackifier. The mould release lubricant disclosed in the present invention is used in construction industry (especially concrete construction) for lubrication during the process of detaching the moulded concrete from the mould (formwork) and prevents adhesion of freshly placed concrete to the forming surface.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: November 7, 2017
    Assignee: MALAYSIAN PALM OIL BOARD
    Inventors: Soh Kheang Loh, Yuen May Choo
  • Patent number: 9809777
    Abstract: The use of nanoparticles of a metal melting below 400° C., preferably bismuth, dispersed in a lubricant for providing a low coefficient of friction coating to interacting surfaces of machinery, such as a powertrain of a motor vehicle.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: November 7, 2017
    Assignee: Applied Colloids, Inc
    Inventor: Gary A. Pozarnsky
  • Patent number: 9809778
    Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making. Also disclosed are polyamine triglyceride compositions containing 8 to 16 nitrogen moieties per triglyceride unit and methods of making.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: November 7, 2017
    Assignee: The United States of America, as Represented by the Secretary of Agriculture
    Inventors: Rogers E. Harry-O'Kuru, Girma Biresaw, Rex E. Murray
  • Patent number: 9809779
    Abstract: The invention provides a lubricating composition comprising an oil of lubricating viscosity, 0.1 wt % to 10 wt % of an overbased detergent, and 0.01 wt % to 5 wt % of a non-hydroxy terminated acylated polyalkylene oxide. The invention further relates to a method of lubricating a mechanical device (such as an internal combustion engine) with the lubricating composition. The invention further relates to the use of the non-hydroxy terminated acylated polyalkylene oxide to provide at least one of (i) improved sludge handling, (ii) reduced lead or copper corrosion, (iii) increased oxidation resistance, (iv) improved acid control, (v) reduced wear (such as cam wear or lifter wear), (vi) retention of total base number of the lubricant, and/or (vii) improved seal compatibility in an internal combustion engine.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: November 7, 2017
    Assignee: The Lubrizol Corporation
    Inventor: Ewan E. Delbridge
  • Patent number: 9809780
    Abstract: The present invention provides a process for preparing a polymer, employing the steps of: (1) contacting a free radical initiator; a chain transfer agent containing a thiocarbonyl thio group and a free radical leaving group; and a radically polymerizable monomer, to form a polymer chain; and (2) contacting the polymer chain of step (1) with at least one of a polyvalent coupling agent, a polymerization inhibitor, a grafting acylating agent, an amine and an oil of lubricating viscosity. The invention further provides compositions and uses for the polymer.
    Type: Grant
    Filed: July 8, 2013
    Date of Patent: November 7, 2017
    Assignee: The Lubrizol Corporation
    Inventors: Marina Baum, Barton J. Schober, Mark C. Davies, Daniel C. Visger, John R. Johnson
  • Patent number: 9809781
    Abstract: Methods for production of multiple biofuels through thermal fractionation of biomass feedstocks are described. The products of said methods are also described.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: November 7, 2017
    Assignee: The University of Toledo
    Inventors: Balakrishna Maddi, Sridhar Viamajala, Sasidhar Varanasi
  • Patent number: 9809782
    Abstract: Fabric care compositions comprising a cationic polymer, a silicone, and a surfactant system. Methods of making and using such compositions.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: November 7, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Rajan Keshav Panandiker, Mark Robert Sivik, Renae Dianna Fossum, Susanne Birkel, Nicholas David Vetter, Heather Anne Doria, Carola Barrera, Bernardo Aguilera-Mercado, Aaron Flores-Figueroa
  • Patent number: 9809783
    Abstract: Fabric care compositions comprising a cationic polymer, a silicone, and a surfactant system. Methods of making and using such compositions.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: November 7, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Renae Dianna Fossum, Nicholas David Vetter, Bernardo M. Aguilera-Mercado, Carola Barrera
  • Patent number: 9809784
    Abstract: The present invention relates to a detergent or cleaning composition, preferably a liquid laundry detergent composition, comprising a sulfonate group-containing copolymer, which is useful in improving anti-soil redeposition in high water hardness conditions and whiteness maintenance benefit of such detergent or cleaning composition. Processes for making and methods of using the detergent or cleaning composition are also encompassed by the present invention.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: November 7, 2017
    Assignee: The Procter & Gamble Company
    Inventors: Xiaoli Wang, Xianling Zhai, Peng Qin, Xiaoyan Liu, Akiko Hemmi, Hirotaka Mizoguchi, Rika Matsumoto
  • Patent number: 9809785
    Abstract: The invention includes ware detergent compositions which prevent buildup of precipitates and also surprisingly provides significant metal protection of items exposed to alkaline detergent composition. According to the invention alkaline ware detergents may include an effective amount of amino carboxylate. Surprisingly, detergents which included amino carboxylate also provided significant metal protection against corrosion, even when traditional corrosion inhibiting components are reduced.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: November 7, 2017
    Assignee: Ecolab USA Inc.
    Inventors: Lisa Maureen Sanders, Andrew M. Jensen, Kristopher Hodgson
  • Patent number: 9809786
    Abstract: Rinse aid compositions, methods of use, and methods of making said composition are disclosed. The rinse aid compositions can be solid or liquid. The rinse aid compositions comprise a defoamer, a sheeting agent, and a terpolyer of maleic, vinyl acetate, and ethyl acrylate. Preferred sheeting agents include one or more alcohol ethyoxylates. Preferred defoamer components include a polymer compound including one or more ethylene oxide groups. The solid rinse aid compositions are preferably substantially free of sulfate and sulfate-containing compounds.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: November 7, 2017
    Assignee: ECOLAB USE INC.
    Inventors: Erik C. Olson, Carter M. Sivernail
  • Patent number: 9809787
    Abstract: The present invention relates a method of obtaining a detergent composition comprising introducing (a) a lipase variant of a parent lipase which variant has at least 60% sequence identity with SEQ ID NO: 2, a substitution at a position corresponding to D254 of the mature polypeptide of SEQ ID NO: 2 and has lipase activity and (b) an anionic surfactant, wherein said composition has increased stability in comparison with a corresponding composition comprising the parent lipase.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: November 7, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Jesper Vind, Lise Munch Mikkelsen, Marco Malten, Allan Svendsen, Kim Borch
  • Patent number: 9809788
    Abstract: A soap bar composition comprising solid soap and an oil-in-water emulsion, wherein the emulsion comprises one or more surfactants and wherein the emulsion is dispersed within the solid soap.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: November 7, 2017
    Assignee: COLGATE-PALMOLIVE COMPANY
    Inventors: Long Pan, Diana Scala, Donghui Wu, Jairaj Mattai, Christine Boyke, Minli Shi, Diane Curley
  • Patent number: 9809789
    Abstract: Cleaning articles including a heat engine incorporated therein. The cleaning article may include a substrate (e.g., a non-woven wipe) including one or more layers. The heat engine may be in the wipe or pad, and includes a reactive metal oxide which upon contact with water, reacts to produce heat. The cleaning article may thus produce water vapor and/or steam upon activation of the heat engine. A venting structure may be provided adjacent to or surrounding the heat engine that includes an impermeable material (e.g., impermeable to water and/or air or other gas), which includes one or more vents through the impermeable material. The venting structure directs water vapor and/or steam to a desired face of the cleaning article, away from the user. A heat barrier layer may insulate a user's hand from the generated heat, and/or a handle may be attachable to the pad.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: November 7, 2017
    Assignee: The Clorox Company
    Inventors: Brian Lin, Kerry Azelton, Vismadeb Mazumder, Maria G. Ochomogo, William R. Ouellette, Bryan K. Parrish, Michael J. Petrin, Richard J. Uriarte
  • Patent number: 9809790
    Abstract: The present invention relates to aqueous compositions of associative polyelectrolyte complexes (PECs), optionally containing surfactants, biocidal agents and/or oxidants, which can provide a cleaning benefit and surface protection to treated articles including reduced soiling tendency, reduced cleaning effort and improved soil repellancy, as well as providing bacteriostatic properties to treated surfaces that thereby gain resistance to water, environmental exposure and microbial challenge.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: November 7, 2017
    Assignee: The Clorox Company
    Inventors: David R. Scheuing, William L. Smith, Michael Kinsinger, Jared Heymann
  • Patent number: 9809791
    Abstract: This disclosure describes a biochemical reactor with a lower divider support structure. The biochemical reactor may include a tank configured to house immobilized carriers and fluid. The biochemical reactor may include a circulation conduit at least partially disposed within the tank. The circulation conduit may include a circulation outlet opening. The biochemical reactor may include one or more vanes disposed proximate to the circulation outlet opening. The biochemical reactor may include a tank recirculation port disposed proximate to a second end. The biochemical reactor may include a tank inlet configured for feeding fluid into the tank. The biochemical reactor may include a tank outlet configured for drawing fluid from the tank. The tank outlet may be disposed proximate to a first end. The biochemical reactor may include a first divider and a second divider. The second divider may include a support structure including a grating configured to withstand variable loads.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 7, 2017
    Assignee: MIH WATER TREATMENT, INC.
    Inventor: Peter J. Hall
  • Patent number: 9809792
    Abstract: The invention relates to a separator for retaining and recirculating cells in a continuous-flow or batch-flow type plastic bag or bottle, which can preferably be operated outside of a bioreactor. Additionally, the invention relates to a method for retaining and recirculating cells within or outside a bioreactor. The invention further relates to a method for producing the separator according to the invention.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: November 7, 2017
    Assignee: BAYER AKTIENGESELLSCHAFT
    Inventors: Joerg Kauling, Juri Seletzky, Jorgen Magnus, Andre Pastor, Helmut Brod
  • Patent number: 9809793
    Abstract: A bioreactor vessel has an optical foam sensor (36) with a foam contact surface for contacting the foam to be detected. The foam contact surface is an inner side of a window (38) transparent to light from the visible and ultraviolet spectral range in an outer wall of the bioreactor vessel (10). An outer side of the window (38) is coupled to an illumination and detection unit (52) with at least one first light source (56) of visible light and at least one photodetector (58) to detect light from the first light source (56) that is reflected in the bioreactor vessel (10). The foam contact surface has a titanium dioxide coating (44) superhydrophilizable by photoactivation with ultraviolet light and the illumination and detection unit (52) has at least one second light source (66) of ultraviolet light.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: November 7, 2017
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventor: Daniel Riechers
  • Patent number: 9809794
    Abstract: The subject invention provides a two-step protocol using pressure cycling technology (PCT) and alkaline lysis for differential extraction of mixtures. In a preferred embodiment the procedure is used in forensic DNA applications such as, for example, DNA testing in the case of rape.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: November 7, 2017
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, PRESSURE BIOSCIENCES, INC.
    Inventors: Bruce R. McCord, Deepthi V. Nori, Nathan P. Lawrence, Richard Schumacher
  • Patent number: 9809795
    Abstract: The invention provides a process for producing ammonia or ammonium from an organic material by fermenting a medium comprising organic material in the presence of a mixed bacterial population capable of ammonification, wherein the fermenting is under conditions, and for a sufficient period of time, to produce a fermentation product that comprises ammonia or ammonium. The organic material includes nitrogenous compounds suitable for conversion to ammonia or ammonium.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: November 7, 2017
    Assignee: DUCTOR OY
    Inventors: Ilona Oksanen, Susanna Kääriäinen, Kerttu Koskenniemi, Nina Virolainen, Saara Hernesniemi
  • Patent number: 9809796
    Abstract: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating cells, such as recombinant cells or cells infected with a virus, and for producing biological products by cell culture processes.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: November 7, 2017
    Assignees: Baxalta GmbH, Baxalta Incorporated
    Inventors: Leopold Gillberger, Manfred Reiter, Wolfgang Mundt, Friedrich Dorner
  • Patent number: 9809797
    Abstract: A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: November 7, 2017
    Assignee: NATIONAL INSTITUTES OF HEALTH (NIH) U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS) DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY
    Inventors: Cassian Yee, Yongqing Li
  • Patent number: 9809798
    Abstract: Thus, provided herein are pericyte progenitor cells (e.g., isolated pericyte progenitor cells), methods for generating pericyte progenitors in clinically relevant numbers for various applications applying macromolecular crowding during cell culture, and methods of using the pericyte progenitor cells.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: November 7, 2017
    Assignee: National University of Singapore
    Inventors: Michael Raghunath, Anna Blocki
  • Patent number: 9809799
    Abstract: The present application relates to novel and improved methods of achieving virus inactivation during a protein purification process.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: November 7, 2017
    Assignee: EMD Millipore Corporation
    Inventor: Alex Xenopoulos
  • Patent number: 9809800
    Abstract: A method for stably and easily producing a parvovirus having a high infectivity titer is provided. The problem is solved by a method for producing a parvovirus having an infectivity titer as high as 108 TCID50/mL or more in a culture supernatant, comprising the steps of inoculating a seed virus of the parvovirus into a culture substrate comprising host cells having a cell density of 1/500 to 1/20 of the cell density of the host cells confluently grown and a medium at a multiplicity of infection of 0.0001 to 0.1, culturing for a period of 5 to 11 times the doubling time of the host cells, and recovering a culture supernatant.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: November 7, 2017
    Assignee: ASAHI KASEI MEDICAL CO., LTD.
    Inventor: Koichiro Yanagida
  • Patent number: 9809801
    Abstract: Provided herein are genetically modified arenaviruses suitable as vaccines against mycobacterial infections. The invention also relates to pharmaceutical compositions and methods for the prevention and treatment of mycobacterial infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing and treating infections in Mycobacterium tuberculosis.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 7, 2017
    Assignee: Université de Genève
    Inventors: Elodie Anne Françoise Belnoue, Stéphanie Gabrielle Darbre Abdelrahman, Arun Thomas Kamath, Paul Lambert, Claire-Anne Siegrist-Julliard, Daniel David Pinschewer
  • Patent number: 9809802
    Abstract: The present invention relates to novel infectious bronchitis virus strains and the uses thereof. The invention particularly relates to an inactivated or attenuated IBV, as well as to vaccine compositions comprising the same and the uses thereof to vaccinate avians. The invention also relates to nucleic acids, infected cells and methods for detecting the infectious bronchitis virus strains of the invention in any sample.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: November 7, 2017
    Assignee: BIOMUNE COMPANY
    Inventors: Wil Solano, Brianna Ford, Chris Luther
  • Patent number: 9809803
    Abstract: This invention provides a vaccinia virus that grows specifically in a cancer cell and damages such cancer cell and the use of such virus for treatment of cancer. Such mitogen-activated protein kinase-dependent vaccinia virus strain lacks functions of vaccinia virus growth factor (VGF) and O1L, it does not grow in normal cells but grows specifically in cancer cells, and it has oncolytic properties that specifically damage cancer cells.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: November 7, 2017
    Assignees: National University Corporation Tottori University, The Chemo-Sero-Therapeutic Research Institute
    Inventor: Takafumi Nakamura
  • Patent number: 9809804
    Abstract: A mutant Bacillus subtilis, which does not express a functional KASIIIA and/or KASIIIB, and method of making; a mutant Rhodospirillum rubrum, which does not express a functional PhaC1, PhaC2, and/or PhaC3, and method of making; method of characterizing substrate specificity of KASIII; method of making mutant KASIII with altered substrate specificity and/or altered level of activity and nucleic acid, vector, host cell/organism, and mutant KASIII; an in vitro, high-throughput spectrophotometric method of assaying KASIII activity; and materials and methods for using KASIII for production of bi-functional fatty acids and the materials so produced.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: November 7, 2017
    Assignee: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Shivani Garg, Huanan Jin, Marna Yandeau-Nelson, Basil J. Nikolau
  • Patent number: 9809805
    Abstract: The present invention relates to a new zinc binding fusion protein that is a fusion protein of glutathione S-transferase (GST) and metallothionein (MT), to which zinc bind, providing an efficacy in preventing or treating a ROS-related disease and heavy metal poisoning.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 7, 2017
    Assignee: ACRO BIOTECH CO., LTD.
    Inventors: Chiao-Wei Lin, Tang-Long Shen, Ko-Chien Chen, Jer-Li Lin, Sheng-Hong Tsai
  • Patent number: 9809806
    Abstract: The present invention relates to alpha-amylases, nucleic acids encoding the alpha-amylases, methods of producing the alpha-amylases, and methods of using the alpha-amylases.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: November 7, 2017
    Assignee: NOVOZYMES A/S
    Inventors: Carsten Andersen, Thomas Agersten Poulsen
  • Patent number: 9809807
    Abstract: A cellulase having improved enzymatic activity is disclosed. The cellulase comprises a modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of Tyrosine at position 161 with Histidine.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: November 7, 2017
    Assignee: DONGGUAN APAC BIOTECHNOLOGY CO., LTD.
    Inventors: Rey-Ting Guo, Chun-Chi Chen, Ya-Shan Cheng, Jian-Wen Huang, Tzu-Hui Wu, Hui-Lin Lai, Cheng-Yen Lin, Tsung-Yu Ko
  • Patent number: 9809808
    Abstract: The present invention relates to endolysin variants comprising an endolysin to which a peptide stretch with membrane or LPS disrupting activity is fused. Moreover, the present invention relates to nucleic acid molecules encoding said modified endolysin variant, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to a method for producing said endolysin variant. Further, the present invention relates to said modified endolysin variant for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, disinfectant or as cosmetic substance. The present invention also relates to the removal or reduction or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: November 7, 2017
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R&D
    Inventors: Yves Briers, Rob Lavigne, Guido Volckaert
  • Patent number: 9809809
    Abstract: The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one E3 ligase recognition motif in the light chain, wherein said E3 ligase recognition motif is preferably a binding motif for the E3 ligase MDM2. The invention further pertains to polypeptides encoded by the polynucleotide of the invention as well as polypeptides comprising one or more amino acid substitutions. Further encompassed by the present invention are vectors and host cells comprising the said polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising said polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.
    Type: Grant
    Filed: November 8, 2012
    Date of Patent: November 7, 2017
    Assignee: MERZ PHARMA GmbH & CO. KGaA
    Inventors: Michael Schmidt, Jurgen Frevert, Fred Hofmann, Gerhard Groer
  • Patent number: 9809810
    Abstract: An apparatus and method for accelerating and/or inhibiting the migration of cells by applying a time-varying magnetic field to induce eddy currents that promote electrotaxis (galvanotaxis) of cells without the need for chemokines or glucose. The present invention can also be used to study and quantify the metastatic potential of different cell lines.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: November 7, 2017
    Assignee: Ohio State Innovation Foundation
    Inventors: Vish Subramaniam, Joseph West, Emily Alkandry, Mohd Nasser, Dinesh Ahirwar, Ramesh Ganju
  • Patent number: 9809811
    Abstract: A method for designing circular permuted proteins using two engineered Mu transposons for easy construction of random circular permuted proteins, the two designed transposons being MuCP-ISC (Mu Circular permutation transposon with Integrated Start Codon) and MuCP-ISSC (Mu Circular permutation transposon with Integrated Start and Stop Codon).
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 7, 2017
    Assignee: New York University
    Inventors: Jin Ryoun Kim, Brennal Pierre, Vandan Shah
  • Patent number: 9809812
    Abstract: The present invention relates to methods for the screening, identification and/or application of microorganisms and/or compositions of use in imparting beneficial properties to plants, and microorganisms and compositions identified therefrom.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: November 7, 2017
    Assignee: BIODISCOVERY NEW ZEALAND LIMITED
    Inventors: Peter John Wigley, Susan Jane Turner, Caroline Elizabeth George
  • Patent number: 9809813
    Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 7, 2017
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Harlan S. Robins, Edus H. Warren, III, Christopher Scott Carlson
  • Patent number: 9809814
    Abstract: This disclosure provides for compositions and methods for the use of nucleic acid-targeting nucleic acids and complexes thereof.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: November 7, 2017
    Assignee: Caribou Biosciences, Inc.
    Inventors: Andrew Paul May, Rachel E. Haurwitz, Jennifer A. Doudna, James M. Berger, Matthew Merrill Carter, Paul Daniel Donohoue
  • Patent number: 9809815
    Abstract: The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: November 7, 2017
    Assignees: GANYMED PHARMACEUTICALS AG, JOHANNES GUTENBERG-UNIVERSITAT MAINZ
    Inventors: Ugur Sahin, Özlem Türeci, Michael Koslowski, Gerd Helftenbein, Korden Walter, Stefan Wöll, Gabriela-Elena Oprea
  • Patent number: 9809816
    Abstract: The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of NANOG, in particular, by targeting natural antisense polynucleotides of NANOG. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of NANOG.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: November 7, 2017
    Assignee: CuRNA, Inc.
    Inventors: Joseph Collard, Olga Khorkova Sherman