Abstract: A measuring instrument for detection of electrical properties in a liquid includes a main body configured to hold a tester, a first pole extending from the main body, and a second pole extending from the main body that is spaced apart from the first pole. The first pole carries a positive probe for attachment to the tester, and the second pole carries a negative probe for attachment to the tester. When the probes are placed in the liquid, electrical properties in the liquid are detected by the tester.

Abstract: A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The coplanar transmission line and ground plane are formed on a first layer of the printed circuit, and the contact via and part-circular ring of ground vias are plated with a conductive biocompatible material on a second layer of the printed circuit. A system uses a network analyzer with the probe to measure electrical properties of biological tissue. Also described is a method of using the system to determine qualities of stored blood.

Abstract: An apparatus is provided for identifying a property value of a fluid which is to be measured, a method for operating such an apparatus, and a method for manufacturing such an apparatus. The apparatus encompasses: a measurement capacitor device bringable into contact with the fluid, the measurement capacitor device having a first electrode, a second electrode, a first dielectric layer, and a second dielectric layer; a first dielectric constant of the first dielectric layer being dependent, in a context of contact with the fluid, on the property of the fluid to be measured; a second dielectric constant of the second dielectric layer being substantially independent of the property of the fluid which is to be measured; a compensation capacitor device that has the second dielectric layer, a third electrode, and a fourth electrode; the compensation capacitor device connected in parallel, or connectable in parallel, with the measurement capacitor device.

Abstract: According to embodiments, an electric field sensor having a sensor electrode is constructed of an electrically conductive material and having one or more outwardly protruding pillars. A screen electrode overlies the sensor electrode and has one or more openings which register with the one or more pillars on the sensor electrode. At least one piezoelectric actuator is connected to the screen electrode so that, when excited by a voltage signal, the piezoelectric actuator modulates the screen electrode toward and away from the sensor electrode at the frequency of the periodic voltage signal. An output circuit configured to detect a voltage, a current output, or both, between the sensor electrode and the screen electrode which is proportional in magnitude to the strength of the electric field.

Abstract: In one aspect, a method for detection of a target in a sample based on the change of electrochemical cyclic voltammetry peak profile is provided. The method may involve at least two or more electroactive moieties (EAMs) comprising a transitional metal complex and an anchor group. Said transitional metal complex may be capable of reversibly or semi-reversibly transferring one or more electrons. Said anchor group may allow said EAMs to covalently attach to a solid support, forming a self-assembled monolayer (SAM) on the surface. At least one EAM may further comprises a capture ligand that can be recognized and bound by a target or a surrogate target. When a sample is introduced to an EAM, the interaction between said capture ligand and said target or surrogate target may lead to change of the properties of the SAM containing all EAMs involved. Said change can be detected by an electrochemical detection system.

Abstract: An electrochemical system with reduced limiting-current behavior is disclosed. The electrochemical system is useful for fuel cells and bio-sensors. In part, the invention relates a method of reducing or eliminating limiting-current behavior in the operation electrochemical systems, in particular those with ion-selective membrane or electrochemical electrodes, by spatially reducing the convection near the membrane or the electrode. The invention further relates to electrochemical systems in which micropores, microarrays or pillar arrays are used to reduce convection in comparison to conventional systems without microarrays, micropores or pillar arrays.

Abstract: The present invention is directed to a method and apparatus for an immunoassay technique that uses amperometric measurements to rapidly analyze different pathogenic microorganisms, including bacteria, viruses, toxins, and parasites and chemical compounds using a disposable element. In accordance with one aspect of the present invention, at least one conductive immunosorbent is used to provide support for antibody immobilization and placed on the top of the working electrode; it could also be used by itself as a working electrode. This immunosorbent or powder can be fabricated of conductive material or nonconductive material over which a conductive material is coated. A membrane cover of the working electrode forms a fluidic chamber having a pore size that is suited to the particular application to insure no contact between the working electrode and counter or silver electrode. The immunoassay can be automated using microprocessor control to reduce the amount of human intervention.

Abstract: Disclosed herein are systems and methods that relate to use of ultramicroelectrodes (UME) in measurement of ion concentration in presence of one or more organic compound(s).

Abstract: A sensor device for detecting and/or measuring gases includes two electrodes. A thin-layered proton-conductive material is fitted between the two electrodes. The gas can be detected and/or measured by a proton gradient that arises due to different gas concentrations.

Abstract: Disclosed are a biosensor, a method of producing the same, and a method of detecting a biomaterial through the biosensor. The biosensor includes a substrate, an insulating layer, source and drain electrodes formed on the insulating layer, a middle-discontinuous channel provided between the source and drain electrodes, and a detection area on which a detection target material is to be fixed, covering the middle-discontinuous channel.

Abstract: A method for checking fault detection of a control device of an internal combustion engine for malfunction of a connected broadband lambda probe, including checking with a fault simulator between the lambda probe and the control device; to simulate faults of the broadband lambda probe, the fault simulator modifies electrical signals between the broadband lambda probe and the control device. A Nernst voltage of the lambda probe and a pump current of the control device are delivered to the fault simulator; the fault simulator delivers a pump current to the lambda probe and a Nernst voltage to the control device; to simulate faults of the lambda probe, the fault simulator modifies the Nernst voltage to the control device as to the Nernst voltage outputted from the lambda probe. Also described is a related fault simulator. The method and fault simulator monitor the fault detection of control devices for lambda probes.

Abstract: The present disclosure relates to an electrode strip, a sensor strip, a system thereof and a manufacturing method thereof. The sensor strip includes a first reactive film, a second reactive film and a vent hole. The first reactive film includes a substrate, a first electrode layer and a first insulation layer. The first end of the first insulation layer is concaved to a first depth to form a first reactive area. The second reactive film includes a second electrode layer and a second insulation layer. The first end of the second insulation layer is concaved to a second depth to form a second reactive area. The vent hole penetrates the second insulation layer, the second electrode layer and the first insulation layer so as to connect the first reactive area and the second reactive area.

Abstract: A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes (9a, 9b) in series with an ion mobility separator (12) forming part of a mass spectrometer. Ions are separated in the FAIMS device (9a, 9b) according to their rate of change of ion mobility with electric field strength. The ions which are onwardly transmitted from the FAIMS device (9a, 9b) are then passed to an ion separator device (12) comprising a plurality of electrodes (12) and an optional ion trapping region (33). Ions are radially confined with the ion separator by application of an AC or RF voltage to the electrodes (12) and ions are separated according to their ion mobility by applying an axial DC voltage gradient which may remain constant as a function of time or which may vary with time.

Abstract: A Pulsed Eddy Current device for inspecting an object made of an electrically conductive material comprising: at least one dual-purpose coil serving a dual purpose of producing a supplied magnetic field in the object and measuring a produced magnetic field emitted by the object, a transmitter circuit driving the dual-purpose coil(s) with an electrical signal, a shut-off current circuit for the transmitter circuit for cutting-off a current in the dual-purpose coil(s) during a cut-off phase of the electrical signal, the shut-off current circuit applying a voltage inversion on the dual-purpose coil(s) and a receiver circuit for reading the produced magnetic field from the dual-purpose coil(s). A method for inspecting an object comprising supplying a voltage on at least one dual-purpose coil, cutting-off a current in the dual-purpose coil(s) by applying a voltage inversion on the dual-purpose coil(s) and receiving, at the dual-purpose coil(s), a produced magnetic field.

Abstract: A system for detecting an interface between polymer-rich phase and solvent-rich phase comprising a liquid-liquid separator configured to receive a polymer solution as an inlet stream produced in a solvent-based polymerization reactor through an inlet feed, wherein the tank is configured to permit the stream to separate into a polymer rich phase and a solvent rich phase; a first sonic transponder for sending a first sonic signal from either a top or bottom of the liquid-liquid separator and for receiving a first reflected portion of the sonic signal, the reflected portion of the sonic signal created by the passage of the sonic signal through a liquid-liquid interface between the solvent rich phase and the polymer rich phase is provided.

Abstract: An environmental measurement apparatus includes an operation unit which calculates a first change in a first oscillation frequency of a first QCM sensor and a second change in a second oscillation frequency of a second QCM sensor. The operation unit corrects the second change based on the first change in a first period and the second change in the first period.

Abstract: A system for determining a material property is disclosed. In some embodiments, a method for determining a material property comprises receiving a set of material responses corresponding to a set of ultrasonic excitations. The set of material responses are determined using measurements to determine a peak response for each of the set of ultrasonic excitations. In some embodiments, a device for making non-destructive in-situ measurements of the elastic yield strength of a sample (e.g., a steel plate or pipeline wall) is disclosed. The device determines the yield strength of a specimen based on transducing ultrasonic waves within the medium and correlating quantifiable characteristics of the resulting frequency response to the intrinsic elastic nonlinearity of the material. In various embodiments, the device includes one or more electrodes, an acoustic termination, a horn, a flange, a collar, power electronics, signal processors, a memory, a user interface, or any other appropriate device component.

Abstract: In a method for registering at least one damage event on a glass surface, particularly a windscreen of a motor vehicle, wherein at least one structure-borne sound signal is registered by a sensor device and the registered structure-borne sound signal is forwarded to at least one analysis unit, it is provided as essential to the invention that a first signal component of the registered structure-borne sound signal is analyzed, that further analysis is not begun until a first amplitude of the registered structure-borne sound signal has decayed, that the curve of the registered structure-borne sound signal is examined for the existence of signal jumps, and that conclusions may be drawn regarding at least one damage incident on the glass surface from the existend of at least one signal jump.

Abstract: A control system (1) for automatically controlling a plurality of devices (2) of a separation and detection process for quantitative sample analysis and according computer program. Such systems and computer programs can be used to operate quantitative sample analysis devices such as for example high performance liquid chromatography (HPLC) devices or the like.

Abstract: Disclosed is an automatic in-vitro diagnosis method for increasing diagnostic reliability and a diagnosis speed by automatically mixing a specimen taken from the body of a person with a reagent in volumes needed to diagnose the state of the person using the specimen, absorbing the mixture solution of the reagent and the specimen with an analysis strip for a predetermined time, and making a diagnosis by analysis.

Abstract: A colorimetric array includes a substrate, a first spot on the substrate, and a second spot on the substrate. The first spot includes a first nanoporous pigment that includes a first nanoporous material and a first immobilized, chemoresponsive colorant. The second spot includes a second nanoporous pigment that includes a second nanoporous material and a second immobilized, chemoresponsive colorant. The first nanoporous pigment is different from the second nanoporous pigment.

Abstract: Many diseases are difficult to diagnose or present with no symptoms that would suggest that medical diagnosis is needed until significant bodily damage has occurred. We disclose a medical toilet that may be used to diagnose disease. The toilet comprises a conduit through which volatile organic compounds travel from the toilet bowl to the environment outside the toilet. The invention includes methods that comprise the steps of training an animal to identify the scent of bodily waste collected from a user that is afflicted with a defined disease. A user's bodily waste is deposited into the medical toilet and the animal is then exposed to the volatile organic compounds traveling through the conduit on the medical toilet. The animal performs an act that signals that the animal has perceived the smell associated with the disease. Thus, we disclose a novel device for diagnosing disease and methods of user thereof.

Abstract: A sensor arrangement for determining the CO2 concentration in an interior space has an NDIR sensor unit that can determine the number of CO2 molecules on an optical measuring section and therefrom the CO2 concentration in an interior space. The sensor arrangement further has an evaluation unit that can calculate the air pressure from measurement values of the NDIR sensor unit and that can carry out an air-pressure compensation on the basis of the value calculated for the air pressure or of an air pressure correction value calculated therefrom for the measurement value of the CO2 concentration determined by the NDIR sensor unit.

Abstract: A modeling framework for estimating crop growth and development over the course of an entire growing season generates a continuing profile of crop development from any point prior to and during a growing season until a crop maturity date is reached. The modeling framework applies extended range weather forecasts and remotely-sensed imagery to improve crop growth and development estimation, validation and projection. Output from the profile of crop development profile generates a combination of data for use in auxiliary farm management applications.

Abstract: The present disclosure provides uses and methods for using compositions comprising a tetrabrachion protein from Staphylothermus marinus or a fragment thereof for detecting and/or recovering a chemical element from a solution or a suspension. The fragment of the tetrabrachion protein includes the right handed coiled coil (RHCC).

Abstract: A photonic sensor system includes: a photodetector; a signal processor coupled to the photodetector; and a sensor structure configured to provide fluid-response selectivity, spatially distribute light, and to receive light from a light source and convey light to the photodetector. The sensor structure includes a plurality of fluid sensitive interferometric nanostructure layers manufactured on a substrate; wherein the plurality of fluid sensitive interferometric nanostructure layers includes alternating high and low porosity layers.

Abstract: The invention provides a sensor system, mote and a motes-system. The sensor system is configured for being contained in a container having a maximum outer dimension less than 10 millimeter and for sensing at least one environmental parameter (T, P, pH, ?). The sensor system includes at least one sensor configured for measuring the at least one environmental parameter and for generating a sensed value (xT, xP). The sensor system includes a storage element and a timer in which the at least one sensor is configured to measuring the at least one environmental parameter at each time triggers (t1, t2, . . . ) from the timer and for storing a sensed value (xT, xP). The sensor system further includes an energy storage comprising a chargeable capacitor being chargeable via electro-magnetic radiation of a predefined frequency, and wherein the sensor system is configured to initiate a sequence of sensed values when the energy storage is charged or is being charged.

Abstract: Disclosed is an electrochemical probe system and an electrical excitation method, used to identify the composition of metals and alloys.

Abstract: A sensor includes a detection portion and an output portion. The detection portion is made of a material that changes in accordance with a ratio of an actual amount of water to an amount of water causing a phase separation in an alcohol containing fuel. The output portion is configured or programmed to output a signal in accordance with a change of the detection portion.

Abstract: Methods, systems, and computer program products for determining a property of construction material. According to one aspect, a material property gauge operable to determine a property of construction material is disclosed. The gauge may include an electromagnetic sensor operable to measure a response of construction material to an electromagnetic field. Further, the electromagnetic sensor may be operable to produce a signal representing the measured response by the construction material to the electromagnetic field. An acoustic detector may be operable to detect a response of the construction material to the acoustical energy. Further, the acoustic detector may be operable to produce a signal representing the detected response by the construction material to the acoustical energy. A material property calculation function may be configured to calculate a property value associated with the construction material based upon the signals produced by the electromagnetic sensor and the acoustic detector.

Abstract: The present disclosure relates to methods and apparatus for the determination of free fatty acids and total fatty acids in a sample. In particular, the present disclosure relates to the determination of free fatty acids and total fatty acids using desorption ionization-mass spectrometry. The methods and apparatus can include either in-source or post-ionization fragmentation of fatty acid containing compounds.

Abstract: A neuroelectric sensor and stimulator system includes a first antenna, a reader coupled to the first antenna for transmitting stimulation controls and power to a second antenna, and for receiving sensor data transmitted from the second antenna via the first antenna, and at least one neuroelectric sensor stimulator array including the second antenna, a rectifier coupled to the second antenna for extracting power transmitted from the first antenna, a controller coupled to the second antenna for decoding controls transmitted from the first antenna to the second antenna for the neuroelectric sensor stimulator array, a plurality of sensors, a multiplexer coupled to the controller and to the plurality of sensors for selecting a single sensor, and a plurality of stimulators coupled to the controller for stimulating neurons, wherein the rectifier, the controller, the plurality of sensors, the multiplexer, and the plurality of stimulators include graphene.

Abstract: A glass pipette such as an electrode for electrophysiological recording is coated with quantum dots. This greatly aids the ability to observe the glass pipette, particular in tissue as the quantum dots provide an excellent performance under two-photon illumination used to visualize objects at depths of hundreds of microns.

Abstract: A method of using a modified melanoma cell capable of quantification of the effects of MEK inhibitors and CDK4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.

Abstract: The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.

Abstract: Described herein are compositions, methods and/or kits for determining the likelihood of a pregnant subject delivering at term, or developing a disorder associated with pregnancy. These compositions, methods and/or kits feature the measurement of the chemotactic activity of peripheral leukocytes, the measurement of ccl2 mRNA expression or the measurement of Fp or Otr protein expression.

Abstract: Application of the present invention enables quantification of fractions of candidate pharmaceutical compounds (a parent compound and its metabolites), one excreted to the basolateral (Basal/Basolateral)-side via transporters and by diffusion, one excreted to the lumen (Apical)-side, and one remained in the cells. This enables determination of the total amount of the administered candidate pharmaceutical compounds and the distribution ratio of the fractions. The kinetics of the administered candidate pharmaceutical compounds can be evaluated, thereby enabling in vitro screening of an enormous number of candidate pharmaceutical compounds for drug candidates exhibiting the efficacy.

Abstract: Acetylcholine and its receptors appeared in evolution before development of a nervous system. Cholinergic agonists functions include proliferation, differentiation, and cell-to-cell contact in protozoa] as well as vertebrate cells. Animal models for infection by Apicomplexan parasites require cell-to-cell contact followed by differentiation of parasite and host cells to produce clinical disease. Experimental infections are produced by introducing parasite infected leukocytes into a host. Binding cholinergic receptors on the parasites and leukocytes with levamisole HCl induces non-progressive infections and absence of signs of disease.

Abstract: A system, method, and article for diagnosing a test set of biological cells. For example, in one embodiment a normal set of cells is characterized using flow cytometry. A centroid and radius are defined for a set of clusters in an n-dimensional space corresponding to a normal maturation for a cell lineage in the normal set of cells. A test set of cells is characterized using flow cytometry and the characterization is compared to the set of clusters.

Abstract: Information on cytokines and cytology obtained from a biological specimen are combined as a method of predicting the risk that dysplasia will progress to cancer. Methods are disclosed herein to augment the evaluation of biological samples from subjects being tested for cancer. In addition to the cell types that are traditionally considered in the morphology-based cytological screening of specimens, methods disclosed herein add evaluations of certain cell types and cytokines that are traditionally discounted or ignored during screening.

Abstract: Provided herein are apparatuses and methods related to a notification-affecting service on a wearable electronic device configured to set a quiet time mode preventing a user-alerting action selected from, for example, a haptic vibration, a visual effect, and an audible effect from alerting a user of the wearable electronic device.

Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least three identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.

Abstract: Disclosed is a cartridge-based detection system to prepare an injected sample to be investigated for determination of a microbial pathogen or another analyte of interest using a detector features a field-safe cartridge. The system features a plurality of reagent chambers located within the cartridge. The system features a rotating cylindrical dial that facilitates a sequential introduction of various fluids contained in each reagent chamber into the dial whereby the fluid washes internally for contact therein. A dial channel is located through the dial. A dual window region of interrogation is centrally located in the dial. The dial is pivoted into position to fluidly connect each mated anterior and posterior reagent chamber via the dial channel. Methods of used are also disclosed.

Abstract: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.

Abstract: The present invention provides a novel sensor for detecting streptavidin (SA). The nucleic acid sensor for analyzing SA of the present invention includes the following nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to SA. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (SA), a loop-forming sequence (L2), and a stem-forming sequence (SD) linked in this order.

Abstract: Disclosed herein are a method for manufacturing a multi-functional bio-material conjugate used as a biosensor for detecting microorganisms, and the like, and a multi-functional bio-material conjugate manufactured by means of the same. The method for manufacturing a multi-functional bio-material conjugate includes: (a) coating a first nanoparticle having magnetic or fluorescent characteristics with protein; (b) manufacturing a conjugate by adsorbing a second nanoparticle having metallic characteristics onto the first nanoparticle coated with protein; and (c) manufacturing the multi-functional bio-material conjugate by adsorbing a bio-material onto the conjugate. The method for manufacturing a multi-functional bio-material conjugate according to the present invention may prevent precipitation of the nanoparticles, easily immobilize the bio-material, and manufacture a bio-material conjugate having multiple functions, by using two kinds of the particles.

Abstract: A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions.

Abstract: Methods for the detection of active lupus nephritis (LN) and worsening renal disease activity and/or active LN in patients diagnosed with systemic lupus erythematosus, using a panel of biomarkers including transferrin (Tf), ceruloplasmin (Cp), alpha-1-acid glycoprotein (AGP1), lipocalin-like prostaglandin D synthetase (L-PGDS), and urinary neutrophil gelatinase associated lipocalin (UNGAL).

Abstract: Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.

Abstract: The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.