Abstract: An exemplary wheelchair comprises a main frame and a seat frame. Drive wheels and pivoting caster wheels are affixed to and support the main frame. The seat frame is connected to the main frame via left and right rear linkage arms, each rear linkage arm having a first end pivotally connected to the main frame and a second end pivotally connected to the seat frame, thereby allowing the seat frame to pivot relative to the main frame around a virtual pivot point. A seat plate having right, left, front, and rear sides is supported by the seat frame. A backrest frame is also connected to the seat frame. Left and right guide slots of the seat frame receive left and right guide rollers rotationally arranged at each end of a laterally oriented shaft connected to the main frame. The rear linkage arms and guide slots are configured so the virtual pivot point of the seat frame moves rearward when the seat frame is moved from an upright position to a tilted position.

Abstract: A bed for hospital stays, of the type that can be articulated and comprising a plurality of sections which correspond to the regions of the back, buttocks, thighs and legs of the in-patient; one of the sections, the one that corresponds to the buttocks region, has at least one portion thereof which is movable and articulated to the section of the backrest and, when the backrest is lifted, is translated, exposing a curved element, which extends from the lying surface downwardly, and being inclined on the curved element contributes together with it to form a cradle for the buttocks region.

Abstract: An adjustable electric bed, comprising a bed frame, a plurality of mutually articulated bed boards and a driving motor for driving the bed boards to rise and fall, wherein the plurality of bed boards at least comprise a head bed board, a fixed bed board, a leg bed board and a foot bed board which are articulated successively, wherein the fixed bed board is fixed with the bed frame, the undersurface of the head bed board is fixedly provided with a head connector, wherein the driving motor at least comprises a head motor and a leg motor, two ends of the head motor are respectively articulated with the bed frame and the head connector, the undersurface of the leg bed board is fixedly provided with leg connector, two ends of the leg motor are respectively articulated with the bed frame and the leg connector.

Abstract: The sleeping-posture-control bed system includes a bed floor including a back-lifting portion for lifting the user's back, a bed-floor support body supporting the bed floor, and a back-lifting driver for lifting the head side of the back-lifting portion. The back-lifting portion includes a back-receiving surface and a head-receiving surface tiltable at different angles. The back-lifting driver lifts the back-receiving surface and the head-receiving surface, satisfying Mathematical Formula (1): 0°<?x?70°,?45°??y<0°, and ?30°??x+?y??(1) where ?x is the tilt angle of the back-receiving surface when tilted, and the tilt angle of the back-receiving surface when the back-receiving surface is not lifted is set to be 0°; and ?y is the tilt angle of the head-receiving surface when the angle of an extended line of the back-receiving surface at the tilt angle ?x is referred to as 0°.

Abstract: A bolster structure system possesses anti-decubitus ulcer characteristics, and may cooperate with a mattress overlay also having anti-decubitus ulcer capabilities as part of a mattress overlay system, in which multiple elongate, positionally adjustable, relatively moveable bolsters are configured for selective placement in conditions of lateral under-engagement with the sides of an overlay to create inclined, lateral side elevations of these sides at locations along the length of the overlay. The bolster structure and overlay may each include a dynamic-response core expanse formed of an open-cell, compressible viscoelastic foam coated with an elastomeric, moisture- and gas-flow-managing, differential-thickness coating structure load-transmissively bonded to the entirety of the outside of said core expanse to function as a dynamically-responsive unit therewith.

Abstract: A nonintegrated mattress topper comprises a cover at least part of which comprises a fabric having a variable vapor transfer property. When the fabric temperature is within a first range consistent with the presence of an occupant on the mattress the fabric exhibits a first vapor transfer rate sufficiently high that the fabric is permeable to vapor transport across the fabric, and when the fabric temperature is lower than the first temperature range and consistent with the absence of an occupant the fabric exhibits a second vapor transfer rate lower than that of the first vapor transfer rate. Also disclosed is an occupant support assembly comprising a mattress and a nonintegrated topper having the variable vapor transfer property. Also disclosed is an occupant support system comprising a mattress and an integrated topper at least part of which is made of a fabric having the temperature dependent vapor permeability.

Abstract: A mattress apparatus including a foam layer, an inflatable air cushion superposed with the foam layer, a first pneumatic line in fluid communication with the air cushion, and a non-shearing layer covering at least a portion of the air cushion. The air cushion can be inflated to support a patient such that the air cushion contours the patient's body and disperse pressure portions over a larger area, thereby helping eliminate pressure points which can cause or worsen skin wounds. The non-shearing layer can help prevent further tearing or pulling of the skin as a patient moves on the mattress. The foam layer can comprise viscoelastic polyurethane. The apparatus can include a removable cover at least partially surrounding the foam layer, inflatable air cushion, pneumatic first line, and non-shearing layer. An air passage can be defined through the removable cover.

Abstract: The invention relates to a device for therapy and training for the back, comprising two elastically deformable bodies (1) which are arranged at a distance from each other, between which a deformable spacer (2) which interconnects both bodies (1) is arranged, said device being characterized in that said spacer (2) is embodied as a spring element in form of a helical spring (2), the ends thereof being bent so as to form journals (2.1) extending in the extension of the helical spring axis, said journals being introduced into blocks (3) fixed in the inside of the bodies (1).

Abstract: Systems and methods for use with haptic devices. A control system for haptic devices determines a first course of action based on a user's motion. Prior to implementing the first course of action, the control system determines if the first course of action would lead to instability in the haptic device which could cause an unsafe situation such as failure of its components. If the first course of action would lead to instability, the control device determines a second course of action that would not lead to instability and implements this second course of action. To assist in this second course of action and to prevent potential oscillation in the haptic device, the control system also selectively dampens a projected action of the haptic device. A haptic device using such a control system is also disclosed.

Abstract: The control method for lower-limb assistive exoskeletons assists human movement by producing a desired dynamic response on the human leg. Wearing the exoskeleton replaces the leg's natural admittance with the equivalent admittance of the coupled system formed by the leg and the exoskeleton. The control goal is to make the leg obey an admittance model defined by target values of natural frequency, resonant peak magnitude and zero-frequency response. The control achieves these objectives objective via positive feedback of the leg's angular position and angular acceleration. The method achieves simultaneous performance and robust stability through a constrained optimization that maximizes the system's gain margins while ensuring the desired location of its dominant poles.

Abstract: The present disclosure provides a universal user assist seat for use with walkers and seating platforms, and walker with said seat. The universal user assist seat may include a base portion, an engagement portion pivotably coupled to an upper surface of the base for engaging a user when a user sits thereon, and a lifting mechanism that provides an assist force to the engagement portion that biases the engagement portion in an upward position from the base. The universal user assist seat may also include at least one attachment mechanism that removably and rotatably couples the base of the user assist seat to at least one of a front cross-member and a rear cross-member of a frame of a walker. The walker may include frame comprising a plurality of leg portions extending between ground engagement portions and handle portions, and the front and rear cross-members.

Abstract: A device that stimulates and aids penis jelqing, or penis milking massage, is disclosed. The device enhances the jelq exercise because it comprises an ergonomic shape that holds and keeps the penis in position by gripping it around the base and squeezing it to make a stroking jelqing motion.

Abstract: In some embodiments, a system may include an inner wearable harness worn, during use, on a torso of a subject. The system may include a plurality of engines which when activated apply an oscillation force. The system may include a positioning system which allows positioning at least one of the plurality of engines on the inner wearable system such that the oscillation force is applied to at least one treatment area of the subject. The oscillation force may mobilize, during use, at least some secretions in an airway within the subject substantially adjacent the treatment area. The system may include an outer harness worn, during use, on a torso of a subject. The outer wearable harness, when activated, adjusts the oscillation force applied by at least some of the activated plurality of engines to the treatment area.

Abstract: An injection bag is formed of a multilayer film, and includes an intermediate layer that includes a mixture of 60 to 90 mass % of a crystalline polyamide resin and 10 to 40 mass % of a noncrystalline polyamide resin. The crystalline polyamide resin has a combined content of a monomer and a low-molecular-weight polymer of 0.8 mass % or less. The noncrystalline polyamide resin includes a semi-aromatic polyamide.

Abstract: A vial gripper and gripper assembly having a base and a clamp extending therefrom made from an elastomeric material. The clamp adapted to retain a vial, ampoule, or other containers therein typically used in the hospital or clinical setting. The gripper assembly includes an elevated body having a guide wherein a gripper is insertable, and wherein the assembly may be further securely stored within a unit tray.

Abstract: A fluid management system for transferring fluid, the system including a connector component comprising a first end and an opposite second end, a first syringe with a distal end that is removably attachable to the first end of the connector component, and a second syringe with a distal end that is removably attachable to the second end of the connector component.

Abstract: The present invention relates to a medical device connector for connecting a piercing device, with a vial comprising a base member. A plurality of grip members, each grip member comprising a distal end (D) and a proximal end (P) and each comprising a wedge portion adapted to temporarily or permanently lock the medical device connector to the vial. The base member further comprises a plurality of flanges, wherein the proximal ends (P) of the grip members are arranged to the flanges. The flanges extend substantially out from the periphery of the base member in a direction substantially perpendicular to the direction of the grip members, wherein the space formed between the flanges of the base member forms at least one grip portion. The present invention provides for a medical device connector which is easy and comfortable to use, which provide good stacking capabilities and which permits a user to readily acknowledge that the medical device connector is correctly assembled with the vial.

Abstract: Devices, systems, and software for providing remote medical therapy to a subject comprising: an apparatus for dispensing one or more medical items from an inventory of medical items, the inventory of medical items risk profiled to a subject, a population, a venue, or a situation; and a connector device comprising: at least one means for communicating with the apparatus for dispensing one or more medical items from an inventory of medical items; at least one means for communicating with a technology device; and a software module enabling communications between the apparatus for dispensing one or more medical items from an inventory of medical items and the technology device.

Abstract: A self-paced, ergonomic feeding bottle with a substantially-straight back sidewall and an “S”-shaped curved front sidewall; where the curved front sidewall comprises two sections: (1) a convex chest section near the top, and (2) a concave handle section near the bottom, comprising a concave crook and a thin waist. The top-heavy bottle has a single plane of symmetry located between the right and left hand sides of the bottle. An anti-vacuum valve can be inserted into a vent hole. Side positioning markers can be used to achieve zero hydrostatic pressure during use. Anti-roll pads are part of the front sidewall.

Abstract: Dental cement compositions (including two-part compositions), kits, and related methods are used for bonding a dental prosthetic appliance to a tooth. A first part includes an amine activator component and a zinc oxide reactive filler, while a second part includes a polymerization initiator (e.g., benzoyl peroxide) and a polymerizable component having a structure including at least one acrylate or methacrylate group at one end and a carboxylic acid group at another end. A temporary cement composition advantageously exhibits reduced compressive and/or bonding strength relative to permanent cement compositions, which provides sufficient strength to facilitate normal use of the teeth while the provisional appliance is in use, while also facilitating easy removal of the provisional appliance for replacement with a permanent appliance at a later time.

Abstract: A curable dental composition comprising an addition-fragmentation agent and a curable dental resin is disclosed.

Abstract: A micro electromechanical ink jet printing system that has a cartridge having a body that defines a core, and a die that contains one or more nozzles. There is a treatment composition contained within the cartridge core. The system further includes a CPU that is programmable and can control the application of the treatment composition from within the cartridge core, through the one or more nozzles to human skin. Typically, the treatment composition will contain a skin treatment ingredient selected from the group consisting of particles, vitamins, yeast and yeast extracts, skin care actives, dyes, colorants and mixtures thereof. There may optionally be provided a bladder or foam block disposed within the cartridge core for suspending and regulating the flow of the treatment composition. The systems of this invention may include an applicator having an applicator head having one or more applicator nozzles which may be in a array.

Abstract: An object of the present invention is to provide an external composition for skin excellent in ultraviolet-ray absorbability. The present invention relates to the external composition for skin comprising (a) an ultraviolet-ray absorber, and (b) an inorganic phosphor. (a) The ultraviolet-ray absorber preferably contains at least one ultraviolet-ray absorber which absorbs UVB. Also, (a) the ultraviolet-ray absorber is more preferably at least one ultraviolet-ray absorber selected from the group consisting of 2-ethylhexyl paramethoxycinnamate, phenylbenzimidazole sulfonic acid, etc.

Abstract: A method for forming a benzophenone derivative product that resistant to absorption by living tissue that includes binding a benzophenone-containing compound with an oxide-containing particle by acid-catalyzed condensation or Friedel-Crafts acetylation to provide a benzophenone derivative having a microscale size. The benzophenone derivative can then be mixed into a lotion. The microscale size of the benzophenone derivative obstructs absorption by cell tissue. The benzophenone derivative may be an oxybenzone derivative.

Abstract: A composition which includes a) ferulic acid ethyl ester and b) one, two or more aryl alkanols. The combination of components a) and b) has an antimicrobial effect on products such as cosmetics.

Abstract: A compliant personal care composition can include a granular personal care composition, including i) from about 20% to about 80%, by weight of the composition, of a surfactant; and ii) from about 3% to about 40%, by weight of the composition, a water insoluble hygroscopic fiber, fine, or filament; wherein the composition is granular before a first simulated use and has a compliance value of about 0.01 kg/mm to about 1.5 kg/mm after 2 simulated uses. The composition may also be at least partially surrounded by a substrate and in the form of an article.

Abstract: The present invention relates to a crosslinked hyaluronic acid gel which derives from the crosslinking of hyaluronic acid or of a salt thereof in the presence of at least an effective amount of at least one endogenous polyamine as a crosslinking agent, said crosslinking being carried out under conditions favourable to the coupling of said hyaluronic acid and of said endogenous polyamine(s).

Abstract: A method for increasing muscular volume of a muscle in a human is provided. The method comprises injecting a composition comprising hyaluronic acid (HA) into one or more than one location of a muscle, thereby increasing the muscular volume as compared to before the injection. The muscle may be an arm, leg, chest, back or buttock muscle, or any other desired muscle. A method for altering a contour of a muscle in a human is also provided, which comprises obtaining an image of the contour of the muscle, determining a new contour, injecting an HA composition into one or more than one location of the muscle to obtain the new contour, thereby altering the contour as compared to before the injection. A use of a composition comprising HA for increasing muscular volume of a muscle in a human is also provided, where the composition is for injection into muscle.

Abstract: Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.

Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a non-crosslinked functionalized lignin oligomer, wherein the functionalized lignin oligomer: (a) has an average number of lignin monomers of from 3 to 8; (b) comprises a polyethylene glycol functional group; (c) comprises a functionalization content between 90 and 0.5% lignin (m/m), wherein the consumer goods product ingredient is an emulsifier, and wherein the lignin oligomer is in the form of an emulsion, and wherein the consumer goods product is in the form of an oral care composition or a detergent composition.

Abstract: The present invention relates to a composition for dyeing keratin fibers, in particular human keratin fibers such as the hair, comprising one or more fatty substances, one or more alkylpolyglucoside nonionic surfactants and/or one or more oxyethylenated C8-C30 fatty acid esters of sorbitan, one or more (poly)alkoxylated fatty alcohol(s), and/or one or more (poly)glycerolated fatty alcohol(s); one or more oxidation bases chosen from (2,5-diaminophenyl)ethanol and also acid salts thereof or solvates thereof such as hydrates, optionally one or more couplers, optionally one or more basifying agent(s), one or more chemical oxidizing agent(s), and whose fatty substance content represents in total at least 10% by weight relative to the total weight of the composition and more particularly at least 25% by weight relative to the total weight of the said composition.

Abstract: The present invention relates to a consumer goods product comprising a consumer goods product ingredient and a lignin oligomer, wherein the lignin oligomer: (a) comprises less than 1 wt % sulphur content; (b) has a number average molecular weight (Mn) of from 800 Da to 1,800 Da; and (c) has a molar ratio of aromatic hydroxyl content to aliphatic hydroxyl content in the range of from 1.2 to 1.9, wherein the consumer goods product ingredient is an emulsifier, and wherein the lignin oligomer is in the form of an emulsion, and wherein the consumer goods product is selected from skin treatment composition, oral care treatment composition, and detergent composition.

Abstract: The present invention generally relates to cosmetic compositions comprising serum derived from cultured keratinocyte and fibroblast cells. The invention also relates to methods of producing serum for use in the cosmetic compositions through novel cell culture techniques.

Abstract: The present disclosure provides methods for preparing vesicles. In general, these methods include steps of providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by dissolving vesicle-forming lipids in a polar-protic water-miscible organic solvent to produce a lipid solution and then lyophilizing the lipid solution. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.

Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Abstract: A composition intended to be employed for therapeutic purposes incorporates an active ingredient (e.g., a source of nicotine) and at a non-active ingredient that is carried by a porous substrate. The non-active ingredient can be a substance that has the capability of affecting the pH of the biological system to which it is applied (e.g., basic substance and/or buffering agent is sorbed onto the porous carrier, so as to be in intimate contact with that carrier). Representative forms of nicotine include free base (e.g., as a mixture of nicotine and microcrystalline cellulose), a nicotine salt (e.g., as nicotine bitartrate) and nicotine polacrilex. The basic substance can be sodium carbonate, and the porous substrate can be microcrystalline cellulose. The composition is useful for treatment of central nervous system conditions, diseases, and disorders, and can be used as a nicotine replacement therapy.

Abstract: The present invention is directed to an aqueous gel composition containing a local anesthetic, a lubricating agent, and a preservative and methods of treating vulvovaginal pain, such as dyspareunia by topically administering said composition.

Abstract: The purpose of the present invention is to provide a technique for formulating a two-layer separation-type ophthalmic solution in which, during storage, an aqueous layer and an oil-containing layer containing squalane are separated from each other, wherein it is possible to homogeneously disperse the oil-containing layer in the aqueous layer while suppressing foaming by shaking the ophthalmic solution before administration, and the homogeneous dispersed state is maintained in a stable manner at least until administration. A two-layer separation-type ophthalmic solution containing squalane and water, wherein hyaluronic acid and/or a salt thereof and polyvinyl alcohol are contained in the ophthalmic solution and the polyvinyl alcohol content is set to 0.025 to 0.

Abstract: Oral liquid colchicine formulations are described herein. Methods of using the oral liquid colchicine formulations are also provided.

Abstract: Provided herein are pharmaceutical compositions comprising nitrogen mustard, for example bendamustine hydrochloride, solid dispersions substantially free of degradants. Also provided are methods of producing and administering nitrogen mustards and in particular bendamustine hydrochloride solid dispersions substantially free of degradants. The pharmaceutical compositions can be used for any disease that is sensitive to treatment with bendamustine hydrochloride, such as neoplastic diseases.

Abstract: The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

Abstract: The invention discloses spray-dried compositions for inhalation and methods for preparing such powder compositions. The compositions of the invention are produced by spray-drying taurine under conditions that (i) retain the physical and chemical stability of the composition during spray drying and upon storage, (ii) protect the powder composition from aggregation and (iii) provide particles suitable for aerosolization.

Abstract: The present invention relates to the development of a targeted delivery system for the oral delivery of probiotics or therapeutic agent for various indications, including and not limited to active and prophylaxis treatment of Clostridium difficile infection, antibiotic associated diarrhea, irritable bowel syndrome, Crohn's disease, intestinal flora replacement, supplemental flora treatments for patients taking antibiotics, and for restoration of balance and signaling between the intestinal microbiome and the intestinal cells in patients under treatment of metabolic syndrome manifestations, specifically diabetes, insulin resistance, obesity, hyperlipidemia and hypertension.

Abstract: The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said capsule comprising said suspension formulation and to the packaging material for the finished capsule.

Abstract: The present invention relates to coated particles and pharmaceutical dosage forms comprising the active substances sensitive to environmental influences. The coating of the present invention provides stability and protection of the active substance to environmental influences and in particular from oxidation and/or environmental humidity by coating.

Abstract: The present invention relates to a simple and convenient process for preparing solid lipid sustained release nanoparticles for delivery of drugs/vitamins, preferably fat soluble vitamins and more specifically Vitamin D3 and retinoic acid (RA). The process involves microemulsion technique. The nanoparticles of Vitamin D3 and RA obtained by the process of the present invention have utility in treatment of diseases like tuberculosis. Use may be extended to other diseases like AMD, diabetic retinopathy, cancers, hyperpigmentation, acne, and osteoporosis.

Abstract: The present invention provides a method for preparing a film comprising a high amount of a sildenafil free base uniformly dispersed therein and having a suitable thickness and size, as well as flexibility providing good handling stability and being not prone to breaking. The present invention also provides a sildenafil free base-containing film prepared from the method.

Abstract: The present invention relates to a cosmetic or pharmaceutical composition comprising N-acetylglucosamine-6-phosphate or a salt thereof and, optionally, a compound of the vitamin A family, and also to a device containing same.

Abstract: Compositions of and methods for using synthetic retinoids as retinoid replacements and opsin agonists are provided.

Abstract: Methods and compositions for stabilizing opsin protein, such as a Pro23His mutant opsin protein, in a vertebrate visual system, by administration of opsin-binding synthetic retinoids, are provided. The mutant opsin protein binds to the synthetic retinoid, which stabilizes the mutant opsin protein and/or ameliorates the effects of the mutant opsin protein on the vertebrate visual system.