Abstract: Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.

Abstract: The present invention provides breast cancer markers based on RECQL mutations, and related methods, uses, agents, and kits. The invention includes methods for determining the susceptibility of a subject to developing breast cancer, and methods for detecting, diagnosing, treating, and predicting responses to treatment for breast cancer.

Abstract: Oligonucleic acid molecules comprising a SNP site at a position corresponding to position 7480 of the bovine signal transducer and activator of transcription (STAT5A) coding sequence (SEQ ID NO: 1). Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of mammals, a method for increasing human and non-human mammal pregnancy rate in natural and artificial reproduction processes. Further provided are cattle breeding methods for improved milk production traits.

Abstract: Disclosed are compositions, assays, methods, diagnostic methods, kits and diagnostic kits for the specific and differential detection of Mycobacterium avium subsp. paratuberculosis from samples including veterinary samples, clinical samples, food samples, forensic sample, an environmental sample (e.g., soil, dirt, garbage, sewage, air, or water), including food processing and manufacturing surfaces, or a biological sample.

Abstract: A gold nanoparticle-based colorimetric assay kit for nucleic acids from viral, bacterial and other microorganisms that detects unamplified or amplified polynucleotides in clinical specimens using unmodified AuNPs and oligotargeter polynucleotides that bind to a pathogen's nucleic acids. A method for detecting a pathogen comprising contacting a sample suspected of containing microbes with a polynucleotide that binds to pathogen nucleic acid and with gold nanoparticles, detecting the aggregation of nanoparticles, and detecting pathogen polynucleotides in the sample when the nanoparticles aggregate (solution color becomes blue) in comparison with a control or a negative sample not containing the virus when nanoparticles do not aggregate (solution color remains red).

Abstract: The present invention relates to a method for the modification of cereal bran, a method for the production of a modified cereal bran product as well as the use of such products in the production of food products.

Abstract: Provided are lectenz molecules, which are mutated carbohydrate processing enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.

Abstract: A method of producing a sugar liquid includes filtering a sugar liquid through a nanofiltration membrane and collecting a sugar liquid from the feed side, wherein a sugar liquid containing an organic liquid compound having a relative dielectric constant of not less than 17 at 25° C. is filtered through the nanofiltration membrane.

Abstract: A device for immobilising the spout on the ends of the trunnions, in a charging installation for a shaft furnace comprising a pivoting material distribution spout (1), the spout being connected to the supporting trunnions (2) by lugs (11) which engage in receptacles (21) formed in the trunnions and which are immobilised therein by pins (3) comprising at their end an eccentric nipple (31) engaging with a lug of the spout to hold the lug immobilised at the bottom of its receptacle, and locking means (4) for rotationally locking the pin.

Abstract: A method of forming a golf club head assembly includes aligning a faceplate with a recess of a club head; welding the faceplate to the club head; then, after welding the faceplate, heating the club head and the faceplate to at least a solvus temperature of the faceplate for a predetermined amount of time; and then, after heating the club head and the faceplate, allowing the club head and the faceplate to air cool.

Abstract: A heating apparatus, a heat treatment apparatus, and a heating method are provided. The heating apparatus includes a workpiece support on which a ring-shaped workpiece is placed, a rotary drive assembly, and a heater configured to heat the workpiece. The workpiece support includes a plurality of rotating rollers arranged in a circumferential direction. The rotary drive assembly is configured to rotate the plurality of rotating rollers to rotate the workpiece placed on the workpiece support along a ring shape of the workpiece. The heater includes a heating coil configured to induction-heat the workpiece on the workpiece support at a heating position, and an actuator configured to move the heating coil at the heating position relative to the workpiece to adjust a distance between the workpiece and the heating coil.

Abstract: A method is provided for producing matte such as copper or nickel matte or crude metal such as blister copper in a suspension smelting furnace such as a flash smelting furnace or a flash converting furnace. Also provided is a suspension smelting furnace such as a flash smelting furnace or a flash converting furnace. The suspension smelting furnace comprises a reaction shaft, a settler in communication with a lower end of the reaction shaft, and an uptake shaft. The settler extending in two opposite directions from a landing zone for a jet of oxidized suspension below the reaction shaft in the settler so that the settler comprises a first settler part on a first side of the landing zone and a second settler part on an opposite second side of the landing zone.

Abstract: The present invention discloses an extracting agent for separating lithium isotopes and an organic extraction phase containing the extracting agent; the organic extraction phase easily enriches 7Li and achieves the separation of lithium isotopes. The present invention also discloses a high-efficiency method for separating lithium isotopes in an aqueous solution, in which the organic extraction phase of the present invention is used, said organic extraction phase being suitable for single-stage and multi-stage extraction processes.

Abstract: In a first aspect, the invention provides aluminum alloy comprising the following composition, all values in weight %: Si 0.25-1.5 Cu 0.3-1.5 Fe up to 0.5 Mn up to 0.1 all other elements including Mg being incidental and present (if at all) then in an amount less than or equal to 0.05 individually, and less than or equal to 0.15 in aggregate, the balance being aluminum. In a second aspect, the invention provides a composite aluminum sheet product comprising a core layer and at least one clad layer wherein the at least one clad layer is an aluminum alloy comprising the following composition, all values in weight %: Si 0.25-1.5 Cu 0.3-1.5 Fe up to 0.5 Mn up to 0.1 all other elements including Mg being incidental and present (if at all) then in an amount less than or equal to 0.05 individually, and less than or equal to 0.15 in aggregate, the balance being aluminum.

Abstract: New 2xxx aluminum alloy bodies and methods of producing the same are disclosed. The new 2xxx aluminum alloy bodies may be produced by preparing the aluminum alloy body for post-solutionizing cold work, cold working by at least 25%, and then thermally treating. The new 2xxx aluminum alloy bodies may realize improved strength and other properties.

Abstract: A carburizing device is configured to perform a carburizing treatment on a treatment target, and includes a furnace body, an insulating container provided inside the furnace body, a furnace bed provided inside the insulating container and on which the treatment target is mounted, and a heat source provided inside the insulating container, in which at least surfaces of main components of the furnace bed, the heat source and the insulating container are made of a ceramic material.

Abstract: A method for making a pitting resistant carbon coating that includes a hydrogenated diamond-like coating (“H-DLC”). The H-DLC is relatively soft and elastic. Unlike hard and/or inelastic coatings in the prior art, the present coatings do not exhibit a loss of adhesion (delamination). A bonding layer may be deposited on a metallic substrate and the deposited H-DLC on the bonding layer.

Abstract: In various embodiments, sputtering targets are formed by introducing molybdenum powder into a sheet bar mold, pressing the powder to form a sheet bar, sintering the sheet bar to form an ingot having a density of at least 90% of a theoretical density, preheating the ingot, rolling the ingot to form a plate, and heat treating the plate.

Abstract: There is provided a method of forming a sealing film to seal a device formed on a substrate, including: supplying a mixture gas including a silicon-containing gas and a halogen element-containing gas or a mixture gas including a silicon-containing gas and a gas containing a functional group having an electronegative property stronger than that of nitrogen, as a first mixture gas, into a processing container; generating plasma of the first mixture gas within the processing container; and forming a first sealing film to cover the device using the first mixture gas activated by the plasma.

Abstract: Disclosed is a deposition apparatus. The deposition apparatus includes a susceptor into which reactive gas is introduced, and a wafer holder provided in the susceptor to receive a substrate or a wafer. The wafer holder comprises a gas feeding part provided at a lateral side of the wafer holder.

Abstract: The present invention relates to a system for processing coated substrates, having the following features: at least one evacuable process box for accommodating at least one substrate with a gas-tightly sealable housing, which forms a hollow space, wherein the housing comprises at least one housing section, which is implemented such that the substrate is thermally treatable by incident electromagnetic thermal radiation, wherein the housing has at least one housing section coupleable to a cooling device for its cooling and at least one housing section not coupled to the cooling device, wherein the hollow space is divided by at least one separating wall into a process space for accommodating the substrate and an intermediate space, wherein the separating wall has one or a plurality of openings and is arranged between the substrate and the housing section coupled to the cooling device, and wherein the housing is provided with at least one sealable gas passage that opens into the hollow space, for evacuating and i

Abstract: According to the present disclosure, a substrate processing apparatus for processing a flexible substrate including a vacuum chamber configured for being evacuated and being configured for having a process gas provided therein, a processing module adapted to process the flexible substrate, wherein the processing module is provided within the vacuum chamber, and a discharging assembly configured to generate a flow of charged particles to discharge the flexible substrate is provided. The discharging assembly is configured to generate an electric field for ionizing a processing gas.

Abstract: The present invention is directed to compositions and methods for forming conversion coatings on a surface of a substrate by contacting a liquid composition to the surface of the substrate at a high temperature (i.e., 400° F. or above).

Abstract: A hot-gas conducting component for a flow machine has a nickel-base wrought alloy as structural material and a hot gas-side lining made from the group of iron-chromium-aluminum-yttrium alloys and a flow machine having a component of this type.

Abstract: The present invention relates to a process for the protection against corrosion of an article, comprising the steps of (a) application of a layer of a corrosion protecting composition comprising (i) an amorphous polymer composition comprising an amorphous polymer having a glass transition temperature of ?20° C. or less and (ii) a water-absorbing filler, on a surface of the article, and (b) application of a mechanical protective layer on top of the layer of said corrosion protecting composition, wherein the article is in a wet environment. The invention further relates to a corrosion protecting composition and to a tape comprising a layer comprising a corrosion protecting composition according to the invention. The invention also relates to an article, comprising (a) a layer of a corrosion protecting composition according to the invention on a surface of the article, and (b) a mechanical protective layer to protect said layer of said composition.

Abstract: An automatic ammonia hydroxide deployment system comprises an ammonia hydroxide deployment device and an automatic ammonia hydroxide deployment controlling device. The ammonia hydroxide deployment device includes a chamber for storing ammonia hydroxide, an ammonia pipe and a water pipe. The automatic ammonia hydroxide deployment controlling device includes an electrical conductivity meter, a liquid level sensor and an operating controller. The electrical conductivity meter is for detecting an electrical conductivity of the ammonia hydroxide in the chamber. The operating controller is configured to obtain an ammonia concentration of the ammonia hydroxide according to the electrical conductivity of the ammonia hydroxide.

Abstract: The present invention relates to an apparatus for producing hydrogen water, and more particularly, to a portable apparatus for producing hydrogen water including: a container held at an upper side to store water; a hydrogen generating unit positioned at a lower part of the container, and for dissolving hydrogen generated by electrolyzing water stored in the container in the water stored in the container, and converting the water in the container to hydrogen water; and a power supply unit for applying power to the hydrogen generating unit. The portable apparatus for producing hydrogen water of the present invention may enable a user to conveniently drink hydrogen water regardless of the time and the place.

Abstract: The present invention provides a method for generating hydrogen by water splitting at a higher hydrogen generation efficiency. In the present method, used is a photoelectrochemical cell comprising a container, a liquid stored in the container, a semiconductor electrode contained in the container, and a counter electrode contained in the container. The semiconductor electrode comprises a first semiconductor layer, a light-transmissive conductor layer; and a second semiconductor layer.

Abstract: This invention relates to a process and reactor for the electrochemical production of hydrogen peroxide. The process comprises producing protons at an anode, transporting produced protons through a cation exchange membrane into catholyte, producing peroxide anions in a cathode membrane assembly comprising a gas diffusion electrode and an anion exchange membrane adjoined to said gas diffusion electrode and in contact with said catholyte, which produced peroxide anions migrate at least in part into said catholyte, and combining protons and peroxide anions in said catholyte to form hydrogen peroxide.

Abstract: An irrigation system is provided. The irrigation system includes a reservoir for storing irrigation water, an electrolytic gas generator, a detector, and a control unit. The electrolytic gas generator is in fluid communication with the reservoir to output a first gas and a second gas generated by the electrolytic gas generator to the irrigation water. The detector is arranged in the water reservoir to detect the concentrations of dissolved first gas and dissolved second gas of the irrigation water to obtain dissolved gas concentration information. The control unit electrically connects to the detector and the electrolytic gas generator receives the dissolved gas concentration information and adjusts the voltage applied to the electrolytic gas generator according to the dissolved gas concentration information to control the type of gas generated by the electrolytic gas generator and the concentrations of dissolved first and second gas of the irrigation water.

Abstract: A method is provided for producing metal by electrolytic reduction of a feedstock comprising an oxide of a first metal. The method comprises the steps of arranging the feedstock in contact with a cathode and a molten salt within an electrolysis cell, arranging an anode in contact with the molten salt within the electrolysis cell, and applying a potential between the anode and the cathode such that oxygen is removed from the feedstock. The anode comprises a second metal, which at the temperature of electrolysis within the cell is a molten metal. The second metal is a different metal to the first metal. Oxygen removed from the feedstock during electrolysis reacts with the molten second metal to form an oxide comprising the second metal. Thus, oxygen is not evolved as a gas at the molten anode.

Abstract: Tin or tin alloy plating liquid with a sufficient plated deposit can be formed in the opening without causing burns on the plated film surface or abnormal deposits, and which has a good via filling effect. When a specific ?, ?-unsaturated carbonyl compound is added into the tin or tin alloy plating liquid, the plating liquid with good via filling performance can be obtained, and the deposit which is substantially free of voids and burns or abnormal deposits on the deposit surface are reduced.

Abstract: The purpose of the present invention is to provide an electrical Al plating bath that poses little danger of exploding or igniting as a result of contacting air or water, and contains no benzene, toluene, xylene, naphthalene, or 1,3,5-trimethylbenzene, which have detrimental effects to humans. The present invention provides an electrical aluminum or aluminum alloy fused salt plating bath that is obtained by heat treatment of an electrical aluminum or aluminum alloy fused salt plating bath containing (A) a halogenated aluminum as the primary component and (B) at least one other type of halide after adding (C) one, two or more reducible compounds selected from the group consisting of hydrides of elements in Group 1 Periods 2 through 6 of the Periodic Table of Elements and/or hydrides of Group 13 Periods 2 through 6 of the Periodic Table of Elements and amine borane compounds.

Abstract: Methods for forming barrier/seed layers for interconnect structures are provided herein. In some embodiments, a method of processing a substrate having an opening formed in a first surface of the substrate, the opening having a sidewall and a bottom surface, the method may include forming a layer comprising manganese (Mn) and at least one of ruthenium (Ru) or cobalt (Co) on the sidewall and bottom surface of the opening; and depositing a conductive material on the layer to fill the opening. In some embodiments, one of ruthenium (Ru) or cobalt (Co) is deposited on the sidewall and bottom surface of the opening. The materials may be deposited by chemical vapor deposition (CVD) or by physical vapor deposition (PVD).

Abstract: An electroplating cell includes: an anode chamber in which an anode chamber solution is stored; and a separator that separates the anode chamber and a cathode. The electroplating cell undergoes a modification treatment of introducing a carboxylic acid group or a derivative thereof into a base material of the separator. The separator selectively allows permeation of metal ions contained in the anode chamber solution.

Abstract: There is provided a method of manufacturing a metal sheet having an alloy plated layer, the method including a step of passing a metal strip continuously through a plating bath to perform electroplating in the plating bath, the plating bath including a plating liquid and an anode, the plating liquid containing two or more kinds of metal ions for forming the alloy plated layer, wherein an anode obtained by mixing two or more kinds of metal pellets is used as the anode, the metal pellets being formed of respective metals that form the alloy plated layer, wherein a mixing ratio of each metal pellet that constitutes the anode is determined based on a total surface area ratio of each metal pellet in the anode so that a dissolution ratio of each metal pellet that constitutes the anode is a dissolution ratio corresponding to a weight ratio of each metal that constitutes the alloy plated layer.

Abstract: An object of the present invention is to manufacture single crystals of high quality on an industrial production scale by preventing impurities from being mixed in single crystals when the single crystals are produced by the solvothermal method. A pressure vessel body 1, in which a supercritical state is maintained, is made of heat resistant alloy, a portion of the pressure vessel body is open, a corrosion-resistant mechanical lining 5 is provided on an inner face of the pressure vessel and on an entire outer circumferential edge of the opening, and the opening is sealed by an airtight mating face formed out of a corrosion-resistant mechanical lining, which is formed on the outer circumferential edge of the opening, and by an airtight mating face of the corrosion-resistant mechanical lining cover 6 on an inner face of the cover 3 through a corrosion-resistant gasket member.

Abstract: Disclosed herein is a multilayer nanocrystal structure comprising a nanocrystal alloy core comprising two or more nanocrystals and including an alloy interlayer formed at an interface between the two or more nanocrystals, and one or more layers of nanocrystal shells formed sequentially on the surface of the nanocrystal alloy core, wherein the nanocrystal shells each have different band gaps. The multilayer nanocrystal structure can be applied to various electronic devices owing to its advantages of high luminescence efficiency, superior optical stability, and superior chemical stability.

Abstract: A lasing medium having a tailored dopant concentration and a method of fabrication thereof is disclosed. The lasing medium has a single crystal having a continuous body having a selected length, wherein the crystal comprises dopant distributed along the length of the body to define a dopant concentration profile. In one embodiment, the dopant concentration profile results in a uniform heating profile. A method of fabricating a laser crystal having a tailored dopant concentration profile includes arranging a plurality of polycrystalline segments together to form an ingot, the polycrystalline segments each having dopant distributed, providing a crystal seed at a first end of the ingot, and moving a heating element along the ingot starting from the first end to a second end of the ingot, the moving heating element creating a moving molten region within the ingot while passing therealong.

Abstract: Various single crystals are disclosed including sapphire. The single crystals have desirable geometric properties, including a width not less than about 15 cm and the thickness is not less than about 0.5 cm. The single crystal may also have other features, such as a maximum thickness variation, and as-formed crystals may have a generally symmetrical neck portion, particularly related to the transition from the neck to the main body of the crystal. Methods and for forming such crystals and an apparatus for carrying out the methods are disclosed as well.

Abstract: A method for growing a ?-Ga2O3-based single crystal, can provide a plate-shaped ?-Ga2O3-based single crystal having high crystal quality. In one embodiment, a method for growing a ?-Ga2O3-based single crystal employing an EFG method is provided, the method including: bringing a plate-shaped seed crystal into contact with a Ga2O3-based melt, wherein the plate-shaped seed crystal includes a ?-Ga2O3-based single crystal having a defect density of not more than 5×105 /cm2 in the whole region; and pulling up the seed crystal to grow a ?-Ga2O3-based single crystal.

Abstract: Provided are: a method for producing a ?-Ga2O3 substrate of which changes in donor concentration in a reducing atmosphere or an inert gas atmosphere are suppressed; and a method for producing a crystal laminate structure that can epitaxially grow a high-quality crystal film having low variability of quality in a reducing atmosphere or an inert gas atmosphere. The method for producing a ?-Ga2O3 substrate includes a step for cutting out a ?-Ga2O3 substrate from a ?-Ga2O3 crystal containing a group IV element; annealing processing in an atmosphere containing a reducing atmosphere and/or an inert gas atmosphere is performed on the ?-Ga2O3 crystal before cutting out the ?-Ga2O3 substrate, or on the cut-out ?-Ga2O3 substrate.

Abstract: Processes for making fibrous structures and more particularly processes for making fibrous structures comprising filaments are provided.

Abstract: Disclosed is a method of: providing a mixture of a polymer or a resin and a transition metal compound, producing a fiber from the mixture, and heating the fiber under conditions effective to form a carbon nanotube-containing carbonaceous fiber. The polymer or resin is an aromatic polymer or a precursor thereof and the mixture is a neat mixture or is combined with a solvent. Also disclosed are a carbonaceous fiber or carbonaceous nanofiber sheet having at least 15 wt. % carbon nanotubes, a fiber or nanofiber sheet having the a polymer or a resin and the transition metal compound, and a fiber or nanofiber sheet having an aromatic polymer and metal nanoparticles.

Abstract: A clothing wire for a clothing roller of a carding machine extends in a wire longitudinal direction and having a base segment, which is thicker transversely to the wire longitudinal direction. A leaf segment, which is narrower compared to the base segment, protrudes from the base segment. A plurality of teeth is formed on the leaf segment along the clothing wire in the wire longitudinal direction. Each tooth has two leaf segment lateral surfaces adjoining the base segment. On at least one of the leaf segment lateral surfaces, at least one projection is formed on each tooth. The cross-sectional profile of the projection is asymmetric and preferably has the contour of a nose. The design of the clothing wire results in a homogenization or parallelization of the fibers, with little wear of the clothing wire and less damage to the fibers.

Abstract: An add-on weaving method, a device based on this method, 3D fabric items producible by this method and device, and composite materials reinforced with such 3D fabric items. The 3D fabric items are produced directly by the add-on weaving process using Complementary Fabric, warp yarns and weft yarns. The interacting woven fabric produced by interlacing the warp and weft yarns is simultaneously integrated with the Complementary Fabric used. The Complementary Fabric and interacting woven fabric integrate in mutual through-thickness directions at their intersecting planes and create directly 3D fabric items which are useful for manufacturing delamination resistant and high-performance composite materials.

Abstract: A wired kernmantle cord comprises a single continuous length of 20-30 AWG solid, stranded, or braided metal wire coaxially placed in the center of a bundle of seven nylon yarns. The seven yarns each comprise three twisted nylon fibers. The metal wire and the seven yarns thus form a kern that is sheathed inside a woven, braided outer mantle of nylon. The mantle sheathing is woven densely and tightly enough to keep the kern from appearing or working through, and it provides electrical insulation for the metal wire, and weather and abrasion resistance and other environmental protection for the whole.

Abstract: Disposable article or nonwoven that includes a first fiber layer comprising a plurality of fibers, each of which comprising an intimate admixture of a thermoplastic polymer, and a wax and/or oil, wherein at least some of the wax and/or oil is exposed at an outer surface of the fibers and wherein a surface energy treatment is disposed on at least some of the plurality of fibers; and a second fiber layer that is adjacent the first fiber layer and that comprises a plurality of cellulosic fibers.

Abstract: Nonwoven textile fabrics in accordance with the present invention are formed primarily of individualized bast fibers substantially free of pectin. The nonwoven fabric can include staple fibers to a lesser extent than the individualized bast fibers. Individualized bast fibers include fibers derived from the flax and hemp plants. The nonwoven textile fabric is formed into a web while in a dry state and subsequently bonded to produce a nonwoven fabric.

Abstract: Nonwoven textile fabrics in accordance with the present invention include a web of entangled polymeric fibers with substantially pectin-free, individualized bast fibers having a mean length less than 9 millimeters (mm). A method of making a nonwoven fabric includes forming a web of polymeric fibers, forming a randomly arrayed fiber web of the substantially individualized bast fibers having a mean length less than 9 mm, disposing the web of the substantially individualized bast fibers onto the web of polymeric fibers, and entangling the polymeric fibers with the substantially individualized bast fibers to form the nonwoven fabric. In addition, laminates include the nonwoven fabric, a film, and an adhesive disposed between the fabric and the film to bond the nonwoven fabric to the film.