Abstract: The present invention relates to an injection device for automatic spring driven injection of a liquid drug. The injection device has a dose setting mechanism by which doses of an individual size can be set by a user, and a mechanical dose size display for displaying the size of the set dose. The scale drum (20) is coupled to a rotatable dose dial button (10) which is axially retained in relation to the housing (2) and by which the individual doses can be set.

Abstract: A drug pellet delivery system includes a housing having a cavity. A cartridge is positioned within the cavity and includes a body having a channel. The body includes a first pair of rails and a second pair of rails. A plunger is slidably disposed in the housing and the cartridge. The plunger is configured to move a drug depot through the channel and out of the housing. Kits and methods of use are disclosed.

Abstract: The invention relates to a safety device for a syringe for avoiding stab wounds, said syringe to having a syringe body and a piercing means arranged on the distal end of the syringe body. The safety device comprises a sleeve element (6) that extends along an axial direction (X) and encloses at least partly the piercing means and the syringe body, said sleeve element being rotatably mounted on a distal end region of the syringe body. The safety device is characterized by comprising a contact element (7) which contacts the skin of a patient when the syringe is used, said contact element being arranged on the distal end of the sleeve element and being rotatable independent of the sleeve element.

Abstract: A removal device (121, 221) for removing and disposing of a pen needle (113, 213) connectable to a drug delivery device (111, 211) includes a body (123, 223) having a cavity (141, 241) for receiving the pen needle of the drug delivery device such that a patient end (116, 216) of a needle (115, 215) of the pen needle is covered by the body. An ejector (151, 251) is movably connected to the body (123, 223) for engaging the received pen needle (113, 213) and selectively ejecting the engaged pen needle from the body. The pen needle (113, 213) is securely retained within the removal device (121, 221) without exposing the needle (115, 215) of the pen needle until the pen needle (113, 213) can be properly disposed of, such as in a sharps container, thereby substantially preventing an accidental needle stick.

Abstract: Systems and methods are disclosed for bending a needle. A device for bending a needle is disposed around a needle and coupled to an injection device. A force is exerted on the needle to cause the needle to bend upon a bending trough of the device. The device includes a proximal end to interface with the injection device and a distal end having the bending trough. The bending trough is configured to improve bending and prevent breaking of the needle by providing a rounded surface upon which the needle is bent.

Abstract: An assembly and syringe adapter is provided. In one embodiment, an assembly includes a syringe and a syringe adapter. The syringe has a fluid reservoir and a tip that is in communication with the fluid reservoir. Additionally, the adapter has first and second ends, the first end including a cavity configured to receive the syringe tip, and a mating mechanism to permanently engage the syringe tip when the syringe tip is received in the cavity and the adapter is rotated in a first direction relative to the syringe. The adapter may not alter a volume of the syringe to maintain accuracy of volume indicia on the syringe.

Abstract: A method for sealing and flushing a delivery member includes sealing one or more lumens and flushing air from the one or more lumens. An interventional device delivery system includes a handle assembly and a delivery member. The handle assembly includes a catheter holder with a passageway therethrough. A flush block is associated with the catheter holder and has a flush port and a flush chamber. The delivery member is associated with the handle assembly and includes a plurality of catheters. At least one of the catheters has a proximal end disposed within the passageway in the catheter holder and is in fluid communication with the flush chamber.

Abstract: A heated patient tube assembly that carries and gradually warms fluids to a desired temperature and maintains the desired temperature until the fluids are delivered to a patient includes an elongated hollow tube; a heating assembly at least partially embedded within the tube for heating the tube and fluids carried in the tube; and a control assembly for controlling the heating assembly such that the fluids exit the tube at a desired and consistent temperature.

Abstract: A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

Abstract: A heating unit comprising an electrically conductive substrate. A solid fuel layer comprising a metal reducing agent, a metal containing oxidizing agent and a binder is coated on a surface of the substrate, the solid fuel layer having a solid fuel surface spaced from the substrate. A first electrode coupled to the substrate. A second electrode coupled to the solid fuel surface. A power supply is configured to be selectively coupled to the first and second electrodes to provide a voltage between the metallic substrate and the solid fuel surface. The voltage acts to propagate an exothermic metal oxidation-reduction reaction without the use of an igniter.

Abstract: The present document describes a flow measuring apparatus for measuring a flow of particles through a section of a fluid dispensing apparatus, comprising at least one photo-detection device comprising a light source and a detector, wherein the light source is configured to emit electromagnetic radiation onto the detector along a light path, wherein the detector is configured to measure disturbance of the electromagnetic radiation by the flow of particles to provide measurements of the presence, mass and velocity of particles within said section of a fluid dispensing apparatus. Also described is an inhalation apparatus for drug delivery by inhalation comprising a flow measuring apparatus of the present invention.

Abstract: Disclosed herein are hand-actuated aerosol generators, having an adjustable two-compartment medicament container (20) that holds a medicament in a liquid or a fine dry powder form, and connects to a fluid passage; a cap of said container with a jet-sprayer capacity; a mouthpiece (6) through which a medicament released from said jet-sprayer (2) can be inhaled into the respiratory tract by a patient without leakage; a hand-actuated positive air pressure supplier connected to the cap of said medicament container, and an optional spacer that increases inhalation efficiency.

Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.

Abstract: A nasal assembly for delivering breathable gas to a patient includes a frame having an integrally formed first connector portion. A nozzle assembly includes a gusset or base portion and a pair of nozzles. At least one inlet conduit is structured to deliver breathable gas into the frame and nozzle assembly for breathing by the patient. A pair of second connector portions are removably and rotatably connected to respective first connector portions of the frame and are in communication with respective inlet conduits, e.g., directly or via angle connectors. A headgear assembly is removably connected to the pair of second connector portions and/or the angle connectors so as to maintain the frame and the nozzle assembly in a desired adjusted position on the patient's face.

Abstract: A medical device determines operating situations and a method determines operating situations in a medical device. Based on pressure measured values (99) and flow measured values (97), it is determined whether an elevation of an airway pressure (105) in a medical device is due to a cough event (113) or to a plurality of cough events (117), which indicate an accumulation of secretion. An outputting (41, 42, 44) of a warning (44) or alarm (41, 42) is provided indicating the accumulation of secretion.

Abstract: A ventilator (1) determines states with cough attacks and an operating method for a ventilator determines cough attacks. It is determined on the basis of pressure measured values (13, 21, 19) and flow measured values (11, 15, 17) whether consecutive elevations of an airway pressure in a ventilator (1) are due to one cough event or due to a plurality of cough events. A plurality of cough events indicates a state of a cough attack. An output (41, 42, 44) of a warning (44) or alarm (42) is issued indicating the state.

Abstract: A method for the management of secretions in an intubated patient by means of an endotracheal tube to which an inflatable cuff is externally associated, includes the steps of inflating the inflatable cuff for isolating the broncho-pulmonary zone of the patient from the external environment, generating a succession of overpressures inside the endotracheal tube in order to induce breathing in the patient, and a step of deflating the inflatable cuff during the generation of one of the overpressures in order to permit a drainage of the secretions generated by the patient along the trachea towards the outside.

Abstract: Provided is an endotracheal tube, which comprises a baffle, an endotracheal tube body and a pharyngeal suction catheter and is integrally formed. The pharyngeal suction catheter is fixedly connected with an outer wall of the endotracheal tube body. One end of the pharyngeal suction catheter is bent to form a front bent portion, a port of the front bent portion is closed and a side wall of the front bent portion is provided with two suction ports. In the case of oral endotracheal intubation, the pharyngeal suction catheter is introduced to the bottom of the pharynx as the endotracheal tube body is inserted into the weasand, and the pharyngeal suction catheter can stay there for a long period of time, enabling high efficiency of removal of pharyngeal secretions, the reduction of discomfort and adsorption injury of the patient, and the reduction of nursing workload.

Abstract: There is provided a respiratory apparatus. The respiratory apparatus comprises a respiratory interface configured to aid a user in respiration and an attachment configured to hold the respiratory interface in position on the face of the user. The respiratory apparatus also comprises at least one electrode configured to provide electrical stimulation to one or more facial muscles of the user.

Abstract: A headgear for use with a mask includes a first strap being configured to engage a back of a patient's head and extend on either side of the patient's parietal bone behind the patient's ears and assume, in use, a substantially circular or oval shape. At least a portion of the first strap is substantially inextensible. The headgear also includes at least one second strap configured to removably connect the first strap to the mask. The second strap may be more extensible than the first strap. At least a portion of the first strap is self-supporting such that the headgear maintains a three dimensional shape when not in use. The substantially inextensible portion of the first strap is constructed to resiliently return to a predetermined shape when not in use. The arcuate region includes a first portion that may be arranged to align substantially parallel with a top of the patient's head and a second portion being arranged to align substantially to a rear surface of the patient's head.

Abstract: A CPAP device includes a flow generator including an outlet, a humidifier including an inlet, and an adaptor connector between the outlet of the flow generator and the inlet of the humidifier. The connector includes a flexible and conformable sealing portion that is movable to accommodate misalignment.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: A delivery system utilizing a diffusion membrane that regulates the concentration of medical gases that are administered to a patient. A storage vessel contains a neat or pure medical gas under pressure that is in fluid communication with a diffusion membrane. The medical gas is then dispensed at a specified rate by diffusion across a membrane into a carrier gas. The concentration is kept constant by regulating the pressure and carrier gas flow. Typical applications are for inhaled gases that are used in patient treatment and care.

Abstract: The present invention relates to an expiratory valve (10) of a ventilation device (100), comprising a valve body (12) having a fluid inlet (14) and a fluid outlet (16) for breathing air of a patient formed therein, said valve body (12) comprising a support (42) having a top side (46) on which a valve membrane (20) can be placed with an abutment area formed at the outer edge thereof, with the top side (46) of the support (42) having an uneven design.

Abstract: The present invention relates to an expiratory valve (10) of a ventilation device (100), comprising a valve body (12) having a fluid inlet (14) and a fluid outlet (16) for breathing air of a patient formed therein, said valve body (12) having at least one reinforcing rib (36, 38) formed around the fluid inlet (14).

Abstract: The present invention relates to an expiratory valve (10) of a ventilation device (100), comprising a valve body (12) having a fluid inlet (14) and a fluid outlet (16) for breathing air of a patient formed therein, said valve body (12) defining a fluid flow path between fluid inlet (14) and fluid outlet (16), with the cross-sectional area of said fluid flow path expanding in the direction towards the fluid outlet (16).

Abstract: A tinnitus masking system for use by a person having tinnitus. The system comprises a sound delivery system having left and right ear-level audio delivery devices and is configured to deliver a masking sound to the person via the audio delivery devices such that the masking sound appears to originate from a virtual sound source location that substantially corresponds to the spatial location in 3D auditory space of the source of the tinnitus as perceived by the person. The masking sound being represented by left and right audio signals that are converted to audible sound by the respective audio delivery devices.

Abstract: A wireless, programmable and customizable, integrated stroboscopic, eyewear device used as a training tool to enhance the user's sensory processing systems and overall neuro capability (including the underlying pyscho-motor functions). This device functions to elevate and improve the user's perceptual and cognitive processing skills and further measures and collects sensory data from the user during training including heart rate and other Bio statistics. It overall provides for a sensory training tool that builds and strengthen the user's confidence and mental state (ability to spontaneously adjust and respond to unanticipated events). The eyewear device is communicatively coupled to a computing or communication device to transmit data to the receivers.

Abstract: A computerized method for treating a psychopathological condition, the method comprising using at least one hardware processor for presenting to a patient on a computer display at least one visual media and at least audio media; receiving from an eye tracker a gaze direction of at least one eye of the patient; computing a display location of the gaze direction; and when a distance from the gaze location to a target location of the visual media is greater than a threshold value, pausing the audio media for a period of time.

Abstract: A chip may be programmed to emit and/or augment energy tuned to interact with bodily functions through transdermal contact. The chip may be programmed by using a pair of Tesla pancake coils, each coupled to a spherical electrode and driven to create an energetic field between the electrodes. Embodiments may include systems that include the programmed chip in a fabric body. The systems may be wearable so that the effects of the programmed chip may be applied to selected areas of the human body. Some embodiments may be useful for augmenting healing of ailments.

Abstract: An intravascular delivery system includes a delivery sheath capable of transmitting a predetermined tension or compression force in a longitudinal direction while maintaining flexibility to navigate tortuous anatomy. A method of delivering a medical device includes inserting an intravascular device delivery system including a delivery sheath having a continuous spine into a bodily lumen. A distal longitudinal force is applied to the delivery sheath. The distal force is transmitted through the continuous spine and across one or more slit cuts of the delivery sheath. A proximal longitudinal force is applied to the delivery sheath. The proximal longitudinal force is transmitted through the continuous spine of the delivery sheath.

Abstract: A catheter curvature brace, catheter assembly and method for managing fluid in a patient, the brace being attachable to a distal portion of a shaft of a catheter and having an elongated frame with a distal end and a proximal end. The frame is formed with at least one curve in a relaxed curved configuration. At least two coupling elements are connected to the frame, each coupling element configured to engage an outer surface of the catheter. At least the frame is formed of an elastic, biocompatible material capable of being straightened by a force and then returning to the relaxed curved configuration after the force is removed, thereby bending the catheter to substantially conform to the relaxed curved configuration.

Abstract: A telescoping catheter including an elongated tubular member having a proximal end, a distal end, and a passageway extending between the proximal end and the distal end. The tubular member includes a first tubular segment and a second tubular segment. The first tubular segment and the second tubular segment are slidable relative to one another to vary a length of the tubular member. The first tubular segment includes a first connector mateable with a second connector of the second tubular segment to selectively maintain the first and second tubular segments in an extended position. The second tubular segment includes a second proximal end that is mateable with a handle.

Abstract: A steering tool includes an internal tube disposed inside an external tube. The internal and external tubes are arranged for longitudinal axial movement relative to one another. A distal portion of the internal tube is fixedly joined to a distal portion of the external tube. At least one of the tubes may include, over at least some of its length, two continuous, longitudinal zones of solid material separated from each other by a longitudinal gap. At least one of the tubes may include a flexible distal portion distal to the joining zone, the flexible distal portion being more flexible than other portions of that tube.

Abstract: A catheter is responsive to external and internal magnetic field generators for generating signals representing position and pressure data, with a reduced number of sensing coil leads for minimizing lead breakage and failure. The catheter includes a flexible joint with pressure sensing and position coils, at least pair of a pressure sensing coil and a position coil are serially connected. Methods of calibrating a catheter for position and pressure sensing, and detecting magnetic field interference with one catheter by another catheter or other metal or ferrous object advantageously use signals between two sets of sensors as a “back up” or “error check”.

Abstract: A delivery apparatus includes a steerable shaft having a proximal portion, a distal portion, and a pull-wire conduit that extends through the proximal and distal portions. A pull wire extends through the conduit and has a distal portion that is fixed to the shaft. An adjustment mechanism is connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the shaft. The distal portion of the shaft has a steerable portion including one or more layers. A compression-resistance portion is incorporated into a layer of the steerable portion, and extends angularly along a portion of a cross-section of the layer. The layer of the steerable portion into which the compression-resistance portion is incorporated has a first hardness, and the compression-resistance portion has a second hardness that is greater than the first hardness.

Abstract: A medical insertion device includes an introducer assembly, a needle, and a housing. The introducer assembly includes a dilator coaxially disposed in a sheath, the dilator removably engaged to the sheath in an insertion configuration. The needle is coaxially disposed in the dilator, the needle having a distal tip and a proximal end coupled to a needle hub. The housing may be removably engaged to the dilator. The needle hub is movably disposed in the housing between a first locked position, in which the distal tip of the needle extends a first length from a distal end of the dilator, a second locked position, in which the distal tip of the needle extends a second length from the distal end of the dilator less than the first length, and a third locked position, in which the distal tip of the needle is within the dilator.

Abstract: An insertion apparatus for inserting an object into a body comprising a housing, a piercing structure with a lumen, wherein the piercing structure extends distally from the housing, a vacuum chamber that communicates with the lumen of the piercing structure, a plunger configured to fit within the vacuum chamber, a guidewire, and a pressure monitoring channel communicating with the lumen, wherein the insertion apparatus is configured to be operated with a single hand.

Abstract: Embodiments hereof relate to methods of delivering a valve prosthesis to an annulus of a native valve of a heart, the native valve having chordae tendineae. A chordae management catheter is positioned within a ventricle of the heart, the chordae management catheter having a displacement component at a distal end thereof. The displacement component has an annular shape and defines a central lumen therethrough. The displacement component is radially expanded to push chordae tendineae within the ventricle radially outward. A valve delivery system is introduced into the ventricle of the heart via a ventricular wall of the heart. The valve delivery system has the valve prosthesis at a distal portion thereof. The valve delivery system is advanced through the central lumen of the radially expanded displacement component towards the annulus of the native valve of the heart. The valve prosthesis is deployed into apposition with the annulus of the native valve.

Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.

Abstract: The invention is a stent designed for indwelling in a body, where its purpose would be to assist in the drainage of liquid from one part of the body to another. The stent is composed of a material that would typically be coiled to form a cylindrical shape along the length of the stent. Each end of the stent would typically be shaped to form a looped pigtail to prevent migration in the vessel. The stent can be used for minimally invasive procedures or alternatively, it could be placed percutaneously. This stent could be used in various parts of the body, such as the ureter, urethra, bile duct, liver, pancreas, vascular system and neurovascular system.

Abstract: Various systems and methods are provided for reducing pressure at an outflow of a duct, such as the thoracic duct or the lymphatic duct, for example, the right lymphatic duct. A catheter system can be configured to be at least partially implanted within a vein of a patient in the vicinity of an outflow port of a duct of the lymphatic system. The catheter system includes first and second selectively deployable restriction members each configured to be activated to at least partially occlude the vein within which the catheter is implanted and to thus restrict fluid within a portion of the vein. The catheter system includes an impeller configured to be driven by a motor to induce a low pressure zone between the restriction members by causing blood to be pumped through the catheter when the restriction members occlude the vein.

Abstract: Access to a paranasal sinus is provided through implantation of an implant device with a conduit of the implant device disposed through a fistula surgically-formed between a location in the lacrimal apparatus and a paranasal sinus. As implanted, the implant device has a proximal end disposed in the lacrimal apparatus in the orbit, a distal end disposed in the paranasal sinus and an internal passage that provides fluid communication between the lacrimal apparatus in the orbit and the paranasal sinus.

Abstract: Methods for treating hydrocephalus using a shunt, the shunt having one or more CSF intake openings in a distal portion, a valve disposed in a proximal portion of the shunt, and a lumen extending between the one or more CSF intake openings and the valve, the method comprises deploying the shunt in a body of a patient so that the distal portion of the shunt is at least partially disposed within a CP angle cistern, a body of the shunt is at least partially disposed within an IPS of the patient, and the proximal portion of the shunt is at least partially disposed within or proximate to a JV of the patient, wherein, after deployment of the shunt, CSF flows from the CP angle cistern to the JV via the shunt lumen at a flow rate in a range of 5 ml per hour to 15 ml per hour.

Abstract: An implantable containment apparatus for receiving and retaining a biological moiety or a therapeutic device within a tissue bed is disclosed. The device includes a shaping element to maintain the device in a generally toroidal configuration and to return the apparatus to that configuration after deformation. The apparatus can be placed in a host tissue with minimal trauma to the patient. Methods for implanting and using the apparatus are also disclosed.

Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

Abstract: A stent including a hollow wire formed into a stent pattern. The hollow wire includes an outer member having an outer surface and an inner surface, a lumen extending longitudinally within the hollow wire, at least one opening extending from the outer surface of the outer member to the lumen, and a plurality of filaments extending longitudinally within the lumen. The plurality of filaments increases the amount of surface area available for tissue in-growth within the lumen. Each filament of the plurality of filaments is spaced from adjacent filaments of the plurality of filaments, and the spacing between adjacent filaments of the plurality of filaments is configured to permit tissue in-growth between the adjacent filaments.

Abstract: A hand-held applicator for applying a fluid substance to a skin surface is disclosed. The applicator may be wedge-shaped to facilitate the application of the fluid substance to both broad and constricted portions of the user's skin by way of a broad base portion and a narrow end tip portion, respectively. The applicator may also comprise a means for limiting the flow of the fluid substance to the broad base portion of the wedge to facilitate application primarily from the narrow tip portion. The applicator may comprise a means for discharging the fluid substance from the applicator in the form of a user-actuated ratchet member or turning wheel mechanism interconnected to a press plate. The applicator may comprise a handle configured to store in a closed position and to rotate to an open position to enable the application of the fluid substance to hard to reach areas of a skin surface.

Abstract: A hand-held fluid dispensing applicator that includes a fluid source for containing a fluid, said fluid source having a closed distal end and a proximal end for allowing a liquid to be dispensed therethrough during a use; a tongue member; an attachment portion for connection with said proximal end, said attachment portion having a fracture region at a region of intersection of said tongue and said attachment portion, said tongue member extending outwardly from said fracture region of said attachment portion; an absorbent applicator comprising a stem piece comprising a tubular component; and a fracture anvil coupled to the stem piece, the fracture anvil secured within the tubular component, the fracture anvil comprising a passage in which the tongue member is positioned, a movement of the fracture anvil relative to an axis extending lengthwise along a length of the tongue member causing the tongue member to fracture relative to the fracture region, thereby permitting ejection of the liquid from the fluid sourc

Abstract: Described herein is a child-resistant topical drug applicator and methods of applying a topical pharmaceutical composition to a surface. In one aspect, the child-resistant topical drug applicator comprises a container comprising a connector and a tube configured to contain a topical pharmaceutical composition, a sponge applicator fluidly coupled to the connector, and a child-resistant cap that reversibly couples to the connector and encloses the sponge applicator, the cap having a locked position and an unlocked position. Also described herein are methods of opening and using the child-resistant topical drug applicator.