Abstract: A process for simulating correction of human eyeball for better visual acuity includes a processor and coupled memory. The memory stores program for processor to obtain geometric data and a wave-front aberration of human eyeballs and simulate an eyeball model. The eyeball model and an ophthalmic lens model are combined to form a correction system for visual acuity. According to the convex/concave lens imaging rule, and using an object placed in front of the eyeball, a determination is made of an optically uncorrected first image formed at a retina of the eyeball, and a visually-corrected second image formed at the retina of the eyeball. The first object image and the second object image can be output for comparison.

Abstract: Methods for improving gaze tracking are presented. These methods eliminate the need for a separate initial calibration step to determine whether the subject is properly centrally fixated during testing. In one embodiment, whether the subject is centrally fixated is determined by identifying inlier and outlier gaze descriptors; the inliers are assumed to be associated with central fixation. This reduces the total time required for testing. These methods also improve the accuracy of gaze tracking during testing without the need for individual subject calibration. Instead, a database of reference eyes is used. The subject's eye can be compared to the reference eyes, and the mapping function for one or more reference matches can be used to estimate the subject's gaze direction. In another embodiment, previous calibration data from the same subject can be used to determine whether the subject is properly centrally fixated and/or the direction of the subject's gaze.

Abstract: The present invention is directed to an apparatus for identifying the rate of frequency at which a person perceives distinct visual images or sounds. The device, product and method comprise means for presenting the image(s) or sounds, means for selecting the distinct image(s) or sounds, means for selecting an instance number, presenting the image or sound in an amount equal to the instance number, the distinct image being displayed on a screen, the sound being presented via a speaker, at a first frequency rate at which frequency the person in unable to perceive the correct number of images or sounds, means for decreasing the frequency rate presentation of the distinct image or sound to a second frequency rate, the second frequency rate being the frequency at which the person is able to perceive individual occurrences of the image or sound in an amount equal to the instance number, and capturing the value of the second display frequency.

Abstract: An ophthalmic system and method for imaging an eye includes an eye guard, an objective lens, such that light passes through the objective lens along an illumination path that passes through the eye guard, a light source positioned to emit imaging light along the illumination path, a camera assembly positioned to receive emitted light that is emitted from a back surface of the eye. The light source and the objective lens are positioned such that, when the eye guard is positioned proximate the eye of the patient, the imaging light passes through a first portion of a pupil opening in the eye, and the emitted light passes through a second portion of the pupil opening of the eye that is different from the first portion, and wherein the camera assembly captures an image of the eye using the emitted light.

Abstract: A device for non-invasive determination of intra-ocular pressure comprising a pressure chamber with a flexible membrane for engaging with the cornea of a subject's eye and a strain gauge, wherein the pressure chamber may be internally pressurised and thereby exerts a pressure via the membrane upon both the cornea and the strain gauge to that result in a deflection of the cornea and strains being generated at the strain gauge, which, in turn, enable to establish a correlation between inter ocular pressure and strains.

Abstract: An electrocardiography (ECG) electrode includes a contact element carrier for encompassing a first extremity of a patient, and a first skin contact element arranged on the contact element carrier with a first connection element for detecting a first potential on the first extremity. The ECG electrode also includes at least one second skin contact element arranged on the contact element carrier with a second connection element for detecting a second potential different from the first on the first extremity.

Abstract: An apparatus configured to estimate biometric information includes a sensor configured to measure a light signal reflected from a subject and a temperature of the subject, and a processor configured to perform temperature correction on the light signal reflected from the subject based on the temperature of the subject using a light signal-temperature relationship between the light signal reflected from the subject and the temperature of the subject to thereby obtain a temperature-corrected light signal, and estimate the biometric information of the subject based on the temperature-corrected light signal.

Abstract: Wireless systems and methods include a plurality of peripheral electronic devices each having a wireless communication system. A processor is configured to establish an association confidence level indicative of a likelihood that a peripheral electronic device is associated to a monitored subject for each peripheral electronic device based on association criteria. Indicators are configured to communicate the association the association confidence level.

Abstract: Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

Abstract: The present invention provides a biocompatible circuit assembly that includes a circuit encased within a housing. In some embodiments, the housing is a PMMA housing and before the circuit is enclosed within the housing the circuit is encased within a brick of epoxy.

Abstract: A scan completeness auditing system for screening a volume of tissue comprising a manual image scanning device having an imaging probe, a position tracking system configured to track and record the position of the imaging probe during use, and a controller in communication with the recording system and the manual image scanning device, the controller configured to electronically receive and record the scanned images from the manual image scanning device, and to measure an image-to-image spacing and a scan-to-scan spacing between the scanned images within scan sequence and between scan sequences respectively. The scan completeness auditing system is further adapted to provide an alert to the operator if the image-to-image or scan-to-scan spacing exceeds an acceptable value.

Abstract: Systems and methods for registering pre-operative medical images, such as computed tomography (“CT”) images, to the coordinate space of an ultrasound treatment system are provided. The registration is generally based on minimizing distances between locations associated with an anatomical feature, as identified from the medical images, and spherical surfaces defined by time-of-flight measurements for ultrasound data acquired from the anatomical feature by transducer elements. The locations associated with the anatomical feature, which may be a skull of the subject, can be points or planar surfaces define on the anatomical feature. The registration methods described here can be useful for aberration correction and targeting using an array of high-frequency ultrasound elements. In combination with cavitation monitoring and control, this ultrasound-based registration of CT images could eliminate the need for MRI during these treatments.

Abstract: An imaging steering apparatus includes sensors and an imaging processor configured for: acquiring, via multiple ones of the sensors and from a current position (322), and current orientation (324), an image of an object of interest; based on a model, segmenting the acquired image; and determining, based on a result of the segmenting, a target position (318), and target orientation (320), with the target position and/or target orientation differing correspondingly from the current position and/or current orientation. An electronic steering parameter effective toward improving the current field of view may be computed, and a user may be provided instructional feedback (144) in navigating an imaging probe toward the improving. A robot can be configured for, automatically and without need for user intervention, imparting force (142) to the probe to move it responsive to the determination.

Abstract: A computerized device for processing image data is proposed. The computerized device comprises a receiving unit a receiving unit which is configured to receive optical coherence tomography data of a tissue of a patient, in particular of a retina, a providing unit which is configured to provide a prediction model for processing the optical coherence tomography data, and a processing unit which is configured to process the received optical coherence tomography data using the prediction model for providing at least one prediction parameter for predicting prospective objects of the tissue and/or prospective features allocated to the tissue.

Abstract: Methods of assessing features on a skin surface of a patient, and associated systems and devices, are disclosed herein. In one embodiment, a method of assessing a feature on a patient's skin surface includes capturing (i) an image of the patient's skin surface with a camera of a portable capture device and (ii) range information with an auxiliary range measurement device that is attached to the portable capture device. Based on the range information, a single range value can be determined between the capture device and the patient's skin surface. In some embodiments, a scale can be associated with the image based on the single range value.

Abstract: An optical probe, according to one embodiment, comprises: an optical fiber into which light for irradiating an object is incident from a light source; a lens which focuses the light incident into the optical fiber; and a wavefront modulator on which a pattern is formed so that the wavefront of the light incident into the optical fiber can be modulated, wherein the optical fiber, the lens, and the wavefront modulator are arranged on the same axis, the light passing through the wavefront modulator can form a focus on the same axis, and the resolution or focal depth of the light can be adjusted through a pattern design formed on the wavefront modulator.

Abstract: An apparatus for holding an imaging subject, such as a whole animal, within a photoacoustic computed tomography system with dry acoustic coupling is disclosed. The apparatus includes a dry acoustic coupler with a tubular elastic membrane made of an optically and acoustically transmissive material. The tubular elastic membrane defines a lumen and at least one lumen opening proximate to a membrane end. In use, the lumen of the tubular elastic membrane is positioned within a coupling fluid contained within a tank of the photoacoustic computed tomography system. The apparatus enables contact-free acoustic coupling of the imaging subject with the coupling fluid during PA imaging. The tank may be optionally pressurized to enhance stabilization of the imaging subject within the coupling fluid.

Abstract: There are provided a photoacoustic image generation apparatus and an insert that separately acquire both positional information and surrounding environment information of the insert. A puncture needle is at least partially inserted into a subject. An optical fiber guides light with a first wavelength and light with a second wavelength which are incident while being switched. The light guided by the optical fiber is emitted from a light emitting portion. A light absorption member absorbs the light with the first wavelength emitted from the light emitting portion, generates photoacoustic waves, and transmits the light with the second wavelength emitted from the light emitting portion.

Abstract: A method determines the emergence of an ulcer or a pre-ulcer on at least one foot of a patient provides one or more processors and a modality for receiving at least one foot. The method generates, using a plurality of temperature sensors, discrete temperature data values after receipt of the at last one foot. The plurality of discrete temperature data values represents temperatures at different locations of the at least one foot. Next, the method compares, using a prescribed function, each of the discrete temperature data values to one of a plurality of different predetermined values. The predetermined values are different for at least two different locations of the at least one foot. The method then produces output information indicating an emergence of an ulcer or a pre-ulcer on the at least one foot as a result of comparing.

Abstract: Methods and devices for blood pressure monitoring may include receiving one or more sensor measurements from the at least one sensor. The methods and devices may further include determining at least one of a first blood pressure indication using a first regression representation based on the one or more sensor measurements, a second blood pressure indication using a second regression representation based on the one or more sensor measurements, or a third blood pressure indication using a third regression representation based on the one or more sensor measurements. The methods and devices may include performing a blood pressure selection procedure using the first blood pressure indication, the second blood pressure indication, and the third blood pressure indication to determine an estimated blood pressure indication based on one or more classification characteristics. The methods and devices may further include transmitting the estimated blood pressure indication to the output device.

Abstract: This invention discloses a blood pressure measurement device including a cuff having a bladder wrap around an object to be measured, a MEMS pump for inflating the bladder with air, a pressure sensor for monitoring the pressure in the bladder, and a microcontroller for controlling the pressure sensor to continuously receive pressure signals during the process of inflating the bladder, converting the pressure signals into blood pressure values, and controlling a drive voltage level of the MEMS pump to maintain an air inflation speed of the MEMS pump in a predetermined inflation speed range. The invention further discloses a method for controlling a fixed frequency change of the blood pressure measurement device.

Abstract: A patient monitoring device includes reusable and disposable portions. The disposable portion includes two or more electrodes for coupling to the skin of the patient, a battery, and a first set of electrical contacts. The reusable portion includes a processor, memory, a second set of electrical contacts, and sensing circuitry coupled to the at least two electrodes, wherein the reusable portion is mechanically coupleable to the disposable portion and wherein the reusable portion is electrically coupleable to the disposable portion through the first and second electrical contacts. The sensing circuitry and the processor are powered from the battery through the coupled first and second electrical contacts, and wherein when the reusable portion and the disposable portion are mechanically uncoupled after having been mechanically coupled, the disposable portion is rendered unusable by the process of mechanically uncoupling the reusable portion and the disposable portion.

Abstract: A biomonitor having various functionality for actively monitoring certain vital signs and wellness data is provided. The biomonitor is adapted to compare the wellness data to programmed and/or determined thresholds and call 911 if such wellness data indicates a medical emergency.

Abstract: The present disclosure generally relates to a portable vital monitoring system and a method for monitoring an individual's vitals using a portable vital monitoring system. The portable vital monitoring system includes a stand-alone portable vital monitoring device that allows the individual to detect or measure the individual's vitals. The stand-alone device includes a plurality of sensing devices for detecting data indicative of the individual's vitals and generating one or more signals indicative of the vital data. The system also includes a control unit connected to the sensing devices for processing the signal such that the data can be displayed to and understood by the individual. The system also includes a vital monitoring application in wireless communication with the vital monitoring device via a wireless communication module.

Abstract: A method enables photoplethysmograph measurement of volume status. The method includes the steps of converting photoplethysmograph voltages to volume measurements and characterizing a local microcirculation as a microcosm in a manner allowing a photoplethysmograph to facilitate noninvasive monitoring of systemic status.

Abstract: Provided is an information processing device including: a sensor control unit configured to control a light emission intensity of a light source included in a pulse wave sensor on the basis of a state of a user who is a detection target of the pulse wave sensor.

Abstract: A wearable device is provided. The wearable device according to one embodiment of the present invention includes a body member including a heartbeat sensor, a first band member and a second band member respectively coupled to both ends of the body member, and a flexible battery having a portion accommodated inside the body member and both remaining ends accommodated inside the first band member and the second band member.

Abstract: The invention relates to a new method, as well as diagnosis. A non-invasive marker, systems and equipment are also included.

Abstract: A catheter includes a tip electrode with a shell and a support member to provide a plenum chamber. The support member is formed with a U-shaped passage for a safety line to wrap around and secure the support member (with the shell affixed thereto) to the catheter. Additional passages are formed in the support member to accommodate components such as irrigation tubing, lead wires and a thermocouple wire pair. A method of manufacture provides distal installation and/or anchoring of the safety line, lead wire and thermocouple wire pair in the support member prior to sealing the support member and mounting the shell.

Abstract: The device for locating cardiac arrhythmias comprises a three-dimensional reconstruction of the patient's torso and a number of surface electrodes, wherein the three-dimensional reconstruction of the patient's torso is generated through a number of images obtained by means of at least one camera. In particular, the device comprises elements for locating the surface electrodes, which detect the position of the electrodes with respect to the patient's torso, and data processing elements that generate, on the basis of the three-dimensional reconstruction and the position of the electrodes, a surface electrocardiographic map, and said surface electrocardiographic map has a number of data corresponding to readings of the surface electrodes related to areas of the three-dimensional reconstruction.

Abstract: Methods and devices for correcting electrocardiogram (EKG) indication saturation may include receiving an EKG indication from at least one sensor and determining that a saturation condition has been met in response to receiving the EKG indication. Additionally, the methods and devices may include incrementing an EKG saturation level based on a determination that the saturation condition has been met. Moreover, the methods and devices may include determining whether the EKG saturation level satisfies an EKG saturation threshold. The methods and device may include disregarding at least a second EKG indication in accordance with a determination that the saturation level satisfies the EKG saturation threshold. The methods and devices may further include transmitting the second EKG indication to an output device in accordance with a determination that the saturation level does not satisfy the EKG saturation threshold.

Abstract: A method of generating an electrophysiology map of a portion of a patient's anatomy includes receiving a plurality of electrophysiology data points, each including an associated electrophysiological signal. A template electrophysiology data point and one or more unwanted electrophysiology data points are selected from the plurality of electrophysiology data points. The electrophysiological signal associated with the template electrophysiology data point is defined as a template electrophysiological signal, while the electrophysiological signal(s) associated with the unwanted electrophysiology data point(s) is/are defined as unwanted electrophysiological signal(s). For any given electrophysiology data point, if the morphology of its associated electrophysiological signal is more similar to the morphology of an unwanted electrophysiological signal than to the morphology of the template electrophysiological signal, the given electrophysiology data point is rejected/excluded from an electrophysiology map.

Abstract: The present disclosure relates to systems and methods for analyzing physiological sign information, including information acquisition, data storage, calculation or analysis, processing, result output, etc. The systems may perform a calculation or an analysis on the acquired information by a plurality of algorithms, perform a determination or a processing on the calculation result, and output the determination result of the processed physiological information.

Abstract: A method for automatically discriminating between a supraventricular tachycardia event and a ventricular tachycardia event is provided.

Abstract: A headwear for electroencephalography is provided. The headwear includes a first arm to be attached to an area extending from a forehead or an occiput of a subject to a top of a head of the subject and configured to hold a first electroencephalogram electrode, a second arm connected to the first arm to be attached to a lateral side of the head of the subject and configured to hold a second electroencephalogram electrode, a third arm connected to the first arm to be attached to another lateral side of the head of the subject and configured to hold a third electroencephalogram electrode, a stretchable support member connectable to the first to third arms to cover at least a portion of the head in a direction toward the first arm, and at least one adjusting mechanism to adjust tightness of the first to third arms to the head.

Abstract: Monitoring brain neural activity comprises repeatedly applying electrical stimuli to evoke neural responses in the brain. Neural responses evoked by the stimuli are recorded. The recorded neural responses are assessed for changed characteristics over time, to monitor a time-varying effect on the recorded neural responses of local field potentials arising from a source other than the electrical stimuli.

Abstract: A universal sensor pod provides a native sensing function during a first mode of operation and a secondary sensing function during a second mode of operation. The universal sensor pod may transition from the native sensing function to the secondary sensing function upon detecting that a sensor capable of the secondary sensing function is connected to the universal sensor pod via a smart connector. The universal sensor pod may continue one or more native sensing functions along with the secondary sensing function upon detecting that a sensor capable of the secondary sensing function is connected to the universal sensor pod via a smart connector. A code embedded within the smart connector is transmitted to a processor contained within the universal sensor pod and in response, the processor executes a firmware application that is tailored to the secondary sensing function code in response to receiving the code.

Abstract: Medical catheterization is carried out by receiving a plurality of analog bioelectric signals in respective channels and multiplexing the bioelectric signals in respective selection events. The selection events comprise making a first connection with a reference voltage, thereafter breaking the first connection and making a second connection with one of the bioelectric signals. The method is further carried out by outputting the multiplexed bioelectric signals to an analog-to-digital converter.

Abstract: An analog front end (AFE) system for substantially eliminating quantization error or noise can combine an input of an integrator circuit in the AFE system with an input of the digital-to-analog converter (DAC) circuit in the feedback loop of the AFE system. By combining the input of the integrator with the input of the DAC circuit in the feedback loop, the in-band quantization noise of the filter can be substantially eliminated, thereby improving measurement accuracy.

Abstract: A system and method is useful for treating amblyopia and other conditions by visual stimulation of the brain. Automatic discrimination between a pair or more of similar body organs, such as the eyes is accomplished for improved safety and efficacy of a treatment. Automatic measurement of a physiological parameter or state in response to a stimulation treatment (responsiveness) over time is also accomplished. Measurements are done over time, within the same treatment session, or between the same treatment session to allow for adapting the visual stimulation used for test and assessment purposes, visual stimulation used for treatment, or a combination of testing and treatment.

Abstract: A screen providing a graphical user interface (GUI) for a tissue biopsy system includes a circular area and a plurality of GUI areas of variable size located in the circular area. The plurality of GUI areas includes a first GUI area, a second GUI area, and a third GUI area. The first GUI area is configured to represent a first region of the target site from which at least one tissue specimen has been separated from tissue at the target site by a tissue cutting member. The second GUI area is configured to represent a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site. The third GUI area is configured to represent a third region in which the tissue cutting member is deployed to separate a tissue specimen from tissue at the target site.

Abstract: A system and method for tracking catheter electrode locations with the body of a patient during an MRI scan sequence includes mitigation logic configured to identify one or more impedance measurements that were taken during potentially noise-inducing conditions (i.e., magnet gradients, RF pulses), and were thus subject to corruption by noise. The mitigation logic is configured to replace the potentially corrupt impedance measurements with previously-obtained impedance measurements taken from an immediately preceding acquisition cycle (e.g., from a previous time-slice).

Abstract: An electrophysiology mapping system is provided with modules which can be attached thereto, each module including an item of subcutaneous interventional equipment and information about the item of subcutaneous interventional equipment, including shape information and size information. At least one sensor is placed upon the item of subcutaneous interventional equipment at a known location thereon. This sensor allows for position, and also preferably orientation, of the item within an image presented on a display of the electrophysiology mapping system. The at least one sensor can be at least one electrode or two or more electrodes, with different known positions for the electrode, or electrodes. The at least one sensor can be one or more magnetic field sensors interacting with a magnetic field associated with the electrophysiology mapping system. Transthoracic ultrasound fitted with sensors thereon can also be utilized as a further module attachable to the electrophysiology mapping system.

Abstract: An electrophysiology mapping system utilizes multiple surface electrodes on a body of a patient for visualization of internal bodily structures, and especially cardiac structures. Some such systems can further utilize a magnetic field source adjacent to the patient for internal bodily structure visualization. In place of an intra-cardiac electrode or other intra-cardiac sensor, an echo probe is utilized external to the body. The electrode or other sensor on the echo probe is spaced a known distance from a sound wave detector, such as a piezoelectric crystal which also generates sound waves, the sensor assisting in correlating echo probe sensed patient structural data with patient structural data otherwise gathered by the EP mapping system. This data is integrated together for visualization on the EP mapping display without requiring an intra-cardiac electrode or other intra-cardiac sensor.

Abstract: A medical evaluation system includes an I/O module, a processing module, and an analysis module. The I/O module receives sensory data obtained by a motion sensor disposed in a mobile device carried by a patient at least when the patient is in a non-clinical environment. The processing module extracts medically relevant data from the sensory data received from the sensor in the mobile device. The relevant data includes one or more features of interest in the sensory data. The analysis module derives one or more surrogate biomarkers from the relevant data. The surrogate biomarkers represent at least one of a state or a progression of a medical condition of the patient. The mobile device may be a mobile phone carried by the patient and the sensor may include at least one of an accelerometer or a gyroscope that generates the sensory data to represent movements of the patient.

Abstract: Apparatus for transcutaneous electrical nerve stimulation in a user, the apparatus comprising: a housing; an application unit for providing mechanical coupling between the housing and the user's body; a stimulation unit mounted to the housing for electrically stimulating at least one nerve with at least one stimulation pulse during a therapy session; and a determination unit mounted to the housing and configured to perform at least one of: (i) determining an activity level of the user; (ii) determining a gait characteristic of the user; (iii) determining a balance function of the user; and (iv) determining apparatus placement position on the user.

Abstract: A system has pressure sensors integrated with a first article of footwear worn by a test subject on a left foot, pressure sensors integrated with a second article of footwear, worn by a test subject on a right foot, positioning circuitry determining separation and direction of the first article of footwear relative to the second article of footwear, circuitry collecting readings from the first and second plurality of sensors, and from the positioning circuitry, as variables with respect to time, and communicating the readings to a computerized diagnostic apparatus. The computerized diagnostic apparatus processes the readings for a test period of time, determining gait characteristics for the test subject, including at least stride length and timing, and width of stance, and records the gait characteristics, time and date stamped, in a manner to be retrieved and displayed.

Abstract: A method for distinguishing blinking events and instrument gazes on the basis of an eye-opening width. The eye-opening width represents an instantaneously detected clearance between the eyelids of an eye. In a step of ascertaining, a blinking event is ascertained using at least one blinking limit value. The blinking event is ascertained when an opening width value, which represents the eye-opening width, is smaller than the blinking limit value. In a step of determining, an instrument gaze is determined using a maximum blinking duration. The instrument gaze is determined when the detected blinking event is detected as lasting longer than the maximum blinking duration. The steps of the method are able to be carried out anew when the opening width value is greater than an open limit value following the determination of the instrument gaze.

Abstract: A motor response of a muscle to neural stimulation is assessed. Electrical stimuli are applied from a first electrode to a selected neural pathway to evoke an efferent neural response. A slow neural response upon the neural pathway evoked by the electrical stimuli is observed. Based on the slow neural response, a motor response of at least one muscle to the stimuli is assessed.

Abstract: An epidermal electronics device includes a barrier layer configured to be coupled to a body part of a user, a sensor configured to acquire orientation data regarding the epidermal electronics device, and a control circuit configured to determine at least one of an orientation and an angular motion of the body part based on the orientation data.