Abstract: Chemiluminescence imaging probes for in vivo detection of biological molecules, events, or processes. The CLI probes may feature a portion of a fluorescein molecule and a portion of a luminol molecule. The fluorescein molecule and luminol molecule may be linked by a non-xanthenic aromatic ring. The CLI probes are generally non-toxic and soluble in aqueous solutions such as PBS. The CLI probes may be used to detect specific molecules in vivo.

Abstract: The present application concerns multimodal composite products for imaging, in particular for diagnostic imaging, and optionally for therapy, in particular composite products which are capable of being used as contrast agents, in particular in magnetic resonance imaging (MRI), and/or in imaging techniques such as, for example, in optical imaging, in the optical detection of oxidants, in positron emission tomography (PET), in tomodensitometry (TDM) and/or in ultrasound imaging, and optionally simultaneously for use in therapy. These products are based on a particle comprising or consisting of a portion provided with a contrast agent activity and/or a paramagnetic activity, and a portion provided with a luminescent activity and optionally an oxidant detection activity.

Abstract: Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bubble preparation comprises: a coating film comprising a lipid; and a gas enclosed in an inner cavity formed in the coating film. The coating film comprises an anionic lipid made from distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and the mixed gas comprises perfluoropropane or perfluorobutane.

Abstract: There is provided a diagnostic imaging agent for early bone metastasis from cancer, containing trans-1-amino-[18F]fluorocyclobutanecarboxylic acid or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.

Abstract: The present invention relates to a method for sterilizing a chromatography material, more particularly microporous polymer membranes, to a chromatography material which has been sterilized by the method according to the invention, to the use of the chromatography material sterilized according to the invention for the chromatographic removal of contaminants from a fluid, and to a closed chromatographic filtration system comprising a chromatography material sterilized according to the invention.

Abstract: The present invention is generally related to an apparatus and method for sanitizing a continuous positive airway pressure (CPAP) device, in particular the invention relates to a system, method and device that attach to a CPAP device and sanitizes all of the parts of the CPAP device, including the inner areas of the hose, reservoir and face mask most prone for bacteria buildup. The device has an ozone operating system and one or more ozone distribution lines that distributes ozone to a CPAP device and a non-permeable bag for sanitizing a CPAP mask.

Abstract: Systems and methods for sanitization of surfaces, such as hands, are provided. In general, the described techniques utilize a system including a housing having an active agent receptacle in fluid communication with at least one nozzle, and an air pump in fluid communication with the at least one nozzle. The system also includes a control module configured to control the delivery of an active agent as an aerosol spray through the at least one nozzle in a delivery dose. The delivery dose is expelled onto the surface as a thin uniform layer and dried such that the entire surface sanitization process is completed in less than or equal to 5 seconds. The active agent receptacle can be configured to receive a removable and replaceable cartridge carrying the active agent.

Abstract: Provided is a decontamination apparatus that includes a motorized base with a transport system that is operable to autonomously move the decontamination apparatus. A plurality of UVC bulbs, each of which emits UVC light, are supported at a vertical elevation above the motorized base. A controller controls operation of the transport system to move the decontamination apparatus along a desired route while the UVC bulbs are energized during a decontamination process.

Abstract: The present invention discloses a toilet deodorizer, comprising the following components in percentage by weight: 0.5-7% of fragrance, 0.7-15% of a solubilizer, less than or equal to 0.1% of a preservative, 0.5-8% of a deodorant, 0.1-0.7% of amino acid, 8-15% of propylene glycol, less than or equal to 1% of a toner and the balance of water. The toilet deodorizer is natural in component, harmless, efficient and environment-friendly, convenient to use and rapid in deodorization.

Abstract: Cartridge for volatile substances in the liquid state, such as insecticides or fragrances, of the type including a tray-shaped container closed on one side with a multilayer film, the multilayer film consisting of at least one internal vapour permeable membrane and one external vapour barrier layer. A directing/assisting unit is provided, apt to direct/assist the removal of just a first portion of the external vapour barrier layer—in the form of notches, weakening lines or strengthening lines—along a desired partition line, for cartridge activation.

Abstract: A scent delivery system includes a housing that releases a volatile substance from a porous body into the air. The housing may be part of a scent dispersion device that includes volatilization as directed by a fan and a controller within the housing.

Abstract: A removable replaceable cartridge for use with a liquid diffusing device. The cartridge includes a venturi, a conduit extending to the venturi, a mixing area and an outlet path for atomizing and dispersing a liquid within the cartridge. A diffusion device including a removable replaceable cartridge received within a housing. The housing includes a source of compressed gas which is directed into the cartridge. A venturi head with a unitary body for use with a diffusion device.

Abstract: A liquid spray device with concealed electric conductive structure is used for atomizing the liquid stored therein and then spraying the atomized liquid. The device comprises a base, a control means arranged on a front side of the base, a liquid storage means that can be separately arranged above or below the control means, a spraying means, which comprises a bracket movably pivoted on the control means, a vibrator arranged on the bracket, a liquid sucking outlet that allows the vibrator to abut against the liquid storage means, and a housing covering the base; in particular, a conductive pivoting structure is provided between the control means and the bracket, the bracket is provided with a wire recess, and a wire is provided within the wire recess, which allows one end of the wire is electrically connected to the conductive pivoting structure, while the other end thereof is electrically connected to the vibrator.

Abstract: The present invention relates to absorbent articles comprising species of glyceride copolymers that provide unexpectedly improved softening performance and formulability.

Abstract: A wound management system can comprise a surgically acceptable adhesive disposed over a wound and a surgically acceptable film repositionably disposed over the surgically acceptable adhesive, and methods of managing a wound involving the same.

Abstract: The present disclosure is directed to a closed cell foam matrix for delivering oxygen containing a superabsorbent material oxygen entrapped within the superabsorbent material. The superabsorbent material has at least 15 percent by mass monoethylenically unsaturated carboxylic, sulphonic or phosphoric acid or salts thereof, an acrylate or methacrylate ester that contains an alkoxysilane functionality, and a copolymerizable hydrophilic glycol containing ester monomer. To produce the closed cell foam matrix for delivering oxygen, an alkali hydroxide catalyst is added to the superabsorbent material to form a hydrogel layer. Then, an oxygen precursor is added to the hydrogel layer. The hydrogel layer is heated to produce oxygen by reacting the alkali hydroxide catalyst and the oxygen precursor thereby entrapping the oxygen in the formed closed cell foam matrix.

Abstract: Structured mineral bone substitute moldings having a defined interconnecting pore system and a predetermined structure, to a method for producing structured mineral bone substitute moldings using 3D printing, and to the use thereof for producing an alloplastic implant or as a carrier material in cell culturing, tissue culturing and/or tissue engineering.

Abstract: The present invention relates to a polymeric-based barrier membrane with form memory (1) which is used in periodontitis treatment, comprises, bioactive agents; and a production method (100) of the membrane.

Abstract: The present invention relates to methods for removing antigens from tissues by sequentially destabilizing and/or depolymerizing cytoskeletal components and removing and/or reducing water-soluble antigens and lipid-soluble antigens. The invention further relates to tissue scaffolding and decellularized extracellular matrix produced by such methods.

Abstract: The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.

Abstract: Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

Abstract: Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing the copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettability of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.

Abstract: A surgical irrigation and suction control apparatus connecting to an irrigation device and a suction device includes a flexible cannula, a grip, a first tube, a second tube, an irrigation control unit and a suction control unit. The grip is connected to the flexible cannula. The irrigation control unit includes an irrigation switch and an irrigation tube. The irrigation tube is flexible and is connected between the second tube and the irrigation device. The irrigation switch is disposed on the grip and is actuated to change a diameter of the irrigation tube. The suction control unit includes a suction switch and a suction tube. The suction tube is flexible and is connected between the second tube and the suction device. The suction switch is disposed on the grip and is actuated to change a diameter of the suction tube.

Abstract: A surgical irrigation and suction control apparatus connecting to an irrigation device and a suction device includes a flexible cannula, a grip, a first tube, a second tube, an irrigation control unit and a suction control unit. The grip is connected to the flexible cannula. The irrigation control unit includes an irrigation switch and an irrigation tube. The irrigation tube is flexible and is connected between the second tube and the irrigation device. The irrigation switch is disposed on the grip and is actuated to change a diameter of the irrigation tube. The suction control unit includes a suction switch and a suction tube. The suction tube is flexible and is connected between the second tube and the suction device. The suction switch is disposed on the grip and is actuated to change a diameter of the suction tube.

Abstract: A device for controlling blood flow occurring in a haemorrhagic zone of a biological tissue, includes a flexible plate arranged to be placed opposite this zone, the flexible plate including: substantially leaktight peripheral supporting elements, for applying on the tissue so that the zone is surrounded; a back wall delimiting, with the supporting elements, opposite the zone, a hollow space; connecting elements connecting the hollow space, externally to the flexible plate, to an external aspiration source for creating a vacuum in the hollow space for aspirating and tightly applying the surface of the tissue against the peripheral supporting elements; and a hollow stud placed between the zone and the back wall and hollowed out in its centre on the side of the zone along an axis substantially perpendicular to the back wall, and arranged to be in contact with the zone when the vacuum is created in the space.

Abstract: A mechanism for adjusting occlusion of a roller pump is described, wherein the mechanism is provided with: an elongated rod member oriented on a central axis of a pump head of the roller pump; and a drive member attached to the elongated rod member so as to move along the elongated rod member between a first position and a second position, wherein the drive member is connected to each roller block of a pump rotor of the pump head so that movement of the drive member by constant increments along the elongated rod member causes non-uniform and/or non-linear incremental movement of each roller block in a direction radial to the central axis of the pump head.

Abstract: The invention relates to a blood pump made of titanium with a measuring device for determining flow based on acoustic flow measurement methods, and a blood pump with a temperature sensor and/or a pressure sensor, and a system with a blood pump and an inlet cannula and/or an outlet connector and a method for producing a blood pump with a measuring device.

Abstract: A dialysis bloodline set includes an arterial chamber with upper, lower and central portions, in which the central portion forms a vertical riser tube having a maximum section area less than that of the lower portion. The lower portion has a shoulder which is positioned to deflect blood entering the lower portion to flow across the aperture at the lower end of the riser tube. The bloodline is prepared by filling the arterial chamber with a priming liquid which extends to a level part way up the riser tube and which is partially displaced by the blood to leave a plug of priming liquid within the base of the riser tube above the blood. The plug of priming liquid separates the blood from a gas in the upper part of the arterial chamber while the blood flowing across the aperture forms a dynamic interface.

Abstract: A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, the connector can include a connector body having an outer surface defining a first outer perimeter and an inner surface defining a lumen. The connector can also include a connecting device having an open configuration and a plurality of closed configurations. The connecting device can include first and second members configured to engage each other to secure the fluid conduit to the connector. The connecting device can also include a plurality of closed configurations for securing fluid conduits of different sizes.

Abstract: Dual packaging for fill needles and safety needles are described herein. Such packaging can include hard packaging or blister packs. Also described herein are methods of opening the packaging and operating the needles disposed therein.

Abstract: Single and dual packaging for fill needles and safety needles are described herein. Such packaging can include hard packaging or blister packs. Such packaging can include a cavity or recess in a compartment of the packaging to house an activation element of a safety needle device to prevent accidental activation of the safety needle device prior to use by the user.

Abstract: Packaging for safety needle devices are described herein. Such packaging can include hard packaging for safety needle devices. Such packaging can include a cavity or recess in a compartment of the packaging to house an activation element of a safety needle device to prevent accidental activation of the safety needle device prior to use by the user. Such packaging can include a cavity or recess in a safety needle device to house an activation element located on the inside surface of the compartment of the packaging to prevent accidental activation of the safety needle device prior to use by the user.

Abstract: A hospital bed rail attachment apparatus constructed of molded silicone or another form of elastomeric substance. An embodiment of the present disclosure includes an elongated member having a first appendage, a second appendage, and a central portion extending between the first appendage and the second appendage. The first appendage may include a first protrusion and a first receiving portion being configured to receive the first protrusion. The second appendage may include a second protrusion and a second receiving portion being configured to receive the second protrusion. Embodiments of the present disclosure may include a pair of elongated members being configured to be selectively coupled to a container at a first end and a hospital bed rail at a second end.

Abstract: Some embodiments of an infusion pump system include a pump device with a drive system that is configured to attach with a medicine cartridge in manner that reduces the likelihood of dosage inaccuracies. In one example, the drive system of the pump device can be equipped with a plunger engagement device that is configured to mechanically anchor into a plunger of the medicine cartridge, and then to bias the plunger of the medicine cartridge in a direction toward a piston rod of the drive system.

Abstract: Some embodiments of an infusion pump system may be configured to wirelessly communicate with other devices using near field communication (NFC). In particular embodiments, by incorporating near field communication capabilities into the infusion pump system, user communications with the infusion pump system can be enhanced and simplified.

Abstract: A rolling diaphragm syringe includes a proximal end having an end wall, a distal end having an open-ended discharge neck, a sidewall extending along a longitudinal axis, and a piston engagement portion protruding proximally from a central portion of the end wall and configured for engagement with a piston of a fluid injector. The piston engagement portion has a stem with a first end attached to the end wall, a second end extending proximally from the first end, and at least one protrusion that protrudes radially outward. The sidewall is flexible and rolls upon itself when acted upon by the piston such that an outer surface of the sidewall is folded in a radially inward direction as the piston is advanced from the proximal end to the distal end, and unfolded in a radially outward direction as the piston is retracted from the distal end to the proximal end.

Abstract: Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed. The system may include transfer apparatus and an injection device. The transfer apparatus may have receiving stations for a drug source, such as a vial or vial holder, and for an injection device, and fluid flow pathways for transferring drugs from the source into the injection device. The injection device may include an expandable elastic bladder and an injection cannula that is movable between a plurality of positions.

Abstract: Some embodiments an infusion pump system can be configured to activate an alarm in response to a calculated prediction of the user's future blood glucose levels. Optionally, the predictive calculation of the user's future blood glucose levels can be based at least in part upon a recent blood glucose level, a trend of blood glucose levels over time, and an insulin load of the user.

Abstract: The present disclosure describes embodiments of a patient monitoring system and methods that include the measure and display of hemoglobin statistics. In an embodiment, total hemoglobin trending is displayed over a period of time. Statistics can include frequency domain analysis, which may be unique for each patient monitored. The total hemoglobin trending and/or statistics can further be used to help control the treatment of a patient, such as being used to control IV administration.

Abstract: Disclosed herein is a drug delivery device with a primary drug delivery assembly for the delivery of a primary medicament, with a primary dose setting member; and a secondary drug delivery assembly for the delivery of a secondary medicament with a secondary dose setting member. A dose dial is rotationally constrained with respect to the housing in a first axial position and is rotationally constrained to the primary dose setting member in a second axial position. A bridging component is axially constrained to the dose dial to set a dose of the secondary medicament, wherein rotation of the dose dial to set a dose of the primary medicament causes the dose dial to move relative to the bridging component in axial direction.

Abstract: Contemplated herein is a medication mixing device which can include a housing having therein a first chamber containing a first medicament component and a second chamber provided containing a second medicament component provided with a sealing structure selectively isolating the first chamber from the second chamber. The sealing structure can include a first sealing component having a first sealing interface and a second sealing component having a second sealing interface wherein a first compression force can be applied to the first and second sealing components causes the sealing interfaces to form a seal. The first compression force can then be configured to allow the first sealing component and the second sealing component to maintain at least one degree of freedom with respect to one another.

Abstract: A needle insertion device configured to insert a needle into a lumen of a vessel of a subject, the insertion device comprising an insertion mechanism configured to insert the needle into the lumen of the vessel at high speed, in accordance with one or more predetermined parameters.

Abstract: A drug delivery device comprising a rotatable scale drum, a trigger member, an actuation member, a trigger spring acting on the trigger member and being energized by movement of the actuation member, as well as an end-of-dose switch adapted to be actuated by movement of the trigger member. The trigger member is adapted to be arranged in an axially supported position against the action of the energized trigger spring, and released from the axially supported position when the scale drum is rotated from a set position to an end-of-dose position, whereby the trigger member is moved axially by the trigger spring, the end-of-dose switch thereby being actuated.

Abstract: The invention relates to a syringe support (15, 15?) for supporting an axial position of a syringe (3) relative to a housing (2) of an autoinjector (1), wherein the syringe support (15, 15?) comprises:—a projecting portion (15.3) which projects from the syringe support (15, 15?) in a distal direction (D) and—a flexible portion (15.1) which axially adjoins the projecting portion (15.3) and which is adapted to axially bias the syringe (3) in the distal direction (D) within the housing (2). The invention further relates to an autoinjector (1).

Abstract: A supplemental device configured for attachment to an injection device, the supplemental device comprising: a camera configured to generate camera output indicative of a scene viewable by the camera, and to be located on an optical path with a surface of an injection device attached to the supplemental device in use; a light source having an emission spectrum and configured to illuminate the surface with light within the emission spectrum in use; and a filter configured to be located on the optical path between the camera and the surface in use, the filter being substantially opaque to light across the entire emission spectrum of the light source and substantially transparent to light of at least one frequency outside the emission spectrum of the light source.

Abstract: The present invention relates to a drug delivery device for expelling a dose of drug from a held cartridge and that defines a distal drug outlet end and an opposite proximal end. The drug delivery device comprises: a distal housing component (110) holding a cartridge (113) comprising a liquid drug and a piston slideable arranged therein in an axial direction, and a proximal housing component (101) housing a dose setting and expelling mechanism comprising a piston rod for exerting a force on the piston of the cartridge (113) in a distal direction for expelling a dose. The distal housing component (110) and the proximal housing component (101) are displaceably arranged in axial direction relative to each other for reducing an axial distance between the piston rod (120) and the piston of the cartridge (113).

Abstract: An auto-injector having a body (1) receiving a reservoir (S) and including a piston (P); a piston rod (5) movable between a primed position and an injection position in which the piston rod (5) has moved the piston (P) to inject fluid into an injection site; and a visual, audible, and/or tactile indicator device for indicating that the autoinjector may be removed from the injection site. The autoinjector includes a retarding system to delay actuating the indicator device relative to the end of injection and that includes a dashpot (16), a shear member (19) and a fluid. The dashpot or the shear member is rotatably mounted in the body and the other is stationary in rotation, the turning of one relative to the other being braked by shearing the fluid contained in the dashpot. The dashpot and shear member include projections that impede the flow of the fluid.

Abstract: The disclosure relates to a drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament (M) from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element, wherein the indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.

Abstract: Various embodiments relate to a resetting mechanism for resetting a screw spindle of a drug delivery device including a driving element including two opposite driving pillars, connected to a sidewall and disposed in a chamber, a limiting element, movably engaged with the driving element, and two opposite clamping elements, movably disposed on two sides of the screw spindle, each of the clamping elements including a sliding base wherein the sliding base has a guide rail and a recess and a clamping jaw, connected to the sliding base and disposed in the chamber, wherein the opposite driving pillars slide in the guide rails along with the movement of the driving element, when the driving element moves toward the limiting element, the driving pillars drive the two clamping elements to move toward the screw spindle to make the two clamping jaws clamp the screw spindle and when the driving element moves away from the limiting element, the driving pillars drive the two clamping elements to move away from the screw sp