Patents Issued in August 21, 2018
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Patent number: 10052270Abstract: Described herein are oral care compositions comprising (i) a peroxide whitening agent comprising a whitening complex of crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, (ii) sodium acid pyrophosphate (Na2H2P2O7) in an amount of from 0.05 wt % to 5 wt % based on the weight of the composition, and (iii) less than 3 wt % water based on the weight of the composition.Type: GrantFiled: December 14, 2012Date of Patent: August 21, 2018Assignee: Colgate-Palmolive CompanyInventors: Michael Prencipe, Prakasarao Mandadi, Olivier Garot
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Patent number: 10052271Abstract: A solid stick antiperspirant composition is provided. The antiperspirant composition includes aluminum zirconium tetrachlorohydrex glycine having a concentration from about 10% to about 35% by weight of the composition, an anhydrous liquid carrier, one or more structurants having a concentration from about 15% to about 25% by weight of the composition, wherein the one or more structurants comprises one or more waxes and a non-ionic exthoxylated linear alcohol having a carbon chain length from about 20 to about 40. The solid stick antiperspirant composition is a single phase.Type: GrantFiled: March 8, 2018Date of Patent: August 21, 2018Assignee: The Procter & Gamble CompanyInventors: David Arthur Sturgis, Phi Van Chu, Steven Michael Wujek, Sr.
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Patent number: 10052272Abstract: The present invention relates to a composition comprising isosorbide monooleate, a first surfactant selected from the group consisting of an alkyl glycoside having a weight average of the number of C-atoms in the alkyl chain of more than 11, cocoamidopropyl betaine and mixtures thereof, a second surfactant which is an alkyl glycoside having a weight average of the number of C-atoms in the alkyl chain of less than 11 and water. Furthermore it relates to a process for making this composition and to a cosmetic formulation, comprising this composition.Type: GrantFiled: July 1, 2015Date of Patent: August 21, 2018Assignee: BASF SEInventors: Claudia Stoer, Claus Nieendick, Markus Weissenegger, Daniela Prinz, Mirella Winzek, Jennifer Schoss, Markus Dierker, Norbert Boyxen, Ute Griesbach, Werner Seipel, Werner Mauer
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Patent number: 10052273Abstract: The present invention relates to a method for dyeing keratinous fibers, in particular human keratinous fibers, such as the hair, in which the said fibers are treated starting from one or more cosmetic compositions comprising a) one or more ortho-diphenol(s), b) one or more inorganic titanium salt(s) or alkoxytitanium(s), c) one or more acid(s) and d) optionally one or more chemical oxidizing agent(s), such as hydrogen peroxide or one or more hydrogen peroxide generating system(s).Type: GrantFiled: December 10, 2014Date of Patent: August 21, 2018Assignee: L'OrealInventors: Boris Lalleman, Alain LaGrange
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Patent number: 10052274Abstract: Disclosed is a foam booster that is capable of producing or increasing the amount of foam in any given composition. The foam booster includes a saccharide blend having 30 wt. % to 50 wt. % of an aldohexose or mixture of aldohexoses, 20 wt. % to 55 wt. % of a ketohexose or mixture of ketohexoses; and 10 wt. % to 20 wt. % of a disaccharide or mixture of disaccharides.Type: GrantFiled: February 8, 2017Date of Patent: August 21, 2018Assignee: Coast Southwest Inc.Inventors: Shannon Smith Butz, Amit Patel
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Patent number: 10052275Abstract: Disclosed is a self-reversible reverse latex including: a) 25-80% by mass of a cross-linked anionic polyelectrolyte (P), resulting from the polymerization, for 100 mole percent: i)—of a molar proportion ?30% and ?95% of monomeric units from at least one monomer including a free, partially- or totally-salified strong acid function; and ii)—of a molar proportion >0% and ?5% of at least one monomer with diethylenic or polyethylenic cross-linking; b) 0.5-10% by mass of a terpolymer of stearyl methacrylate, pentacosaethoxylated behenyl methacrylate and N,N-dimethylacrylamide, resulting from the polymerization, for 100 mole percent: of 80-95 mole percent of stearyl methacrylate, of 2.5-10 mole percent of N,N-dimethylacrylamide, and of 2.5-10 mole percent of pentacosaethoxylated behenyl methacrylate, c) 5-40% by mass of at least one oil, and d) 0.1-40% by mass of water; method of preparing same and use thereof as a thickener.Type: GrantFiled: May 29, 2013Date of Patent: August 21, 2018Assignee: SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPICInventors: Paul Mallo, Olivier Braun
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Patent number: 10052276Abstract: A fragrance extending product containing a fragrance treatment complex is disclosed to extend the effective life of the fragrance carried by a fragrance-bearing product, such as perfume and cologne. The fragrance extending product is preferably a spray-on product that can be applied over the top of the fragrance-bearing product. The fragrance treatment complex resists the evaporation of the perfume oils from the fragrance-bearing product, as well as resists removal caused by abrasion and binding with water. The fragrance treatment complex formulation includes acrylates/octylacrylamide copolymer; Polyquaternium 11, a quaternized copolymer; guar hydroxypropyltrimonium chloride, a cationic polymer, and cocamidopropyl PG-dimonium chloride, a phospholipid. Tests have shown that the effective life of a fragrance-bearing product can be more than twelve hours with the application of the fragrance treatment complex over the fragrance-bearing product previously applied to a human body.Type: GrantFiled: February 10, 2017Date of Patent: August 21, 2018Assignee: HBWC CorporationInventors: Paul F. Mazzotta, Josephine Sullivan
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Patent number: 10052277Abstract: Compositions are provided that provide release of fragrance over an extended period of time. The compositions comprise a hydrophilically-modified cross-linked silicone elastomer and an acrylic rheology modifier.Type: GrantFiled: June 28, 2017Date of Patent: August 21, 2018Assignee: Avon Products, Inc.Inventors: Michael A. Lull, William E. McNamara, Glen T. Anderson
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Patent number: 10052278Abstract: A method of treating a person's skin comprising topically applying to skin a composition that includes an effective amount of a hydrolyzed algae extract that includes an exopolysaccharide from Halymenia durvillei and an effective amount of an exopolysaccharide from Vibrio alginolyticus. Topical application of the composition can decrease skin permeability, increase filaggrin production, increase skin moisture, increase occludin production, and/or decrease TNF-? production.Type: GrantFiled: May 26, 2017Date of Patent: August 21, 2018Assignee: Mary Kay Inc.Inventors: Tiffany Carle, Bob Foley, Julia Collier, Wanli Zhao, Geetha Kalahasti
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Patent number: 10052280Abstract: The present disclosure is drawn to a method of treating a patient in need of treatment, comprising identifying a patient in need of treatment for stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, or hypoxia/ischemia; administering a bolus of glyburide to the patient; and administering a continuous infusion of glyburide to the patient at from about 15 ?g/hr and about 300 ?g/hr, wherein the continuous infusion glyburide is administered for a period of time more than about 20 hours.Type: GrantFiled: February 6, 2017Date of Patent: August 21, 2018Assignee: Biogen Chesapeake LLCInventor: Sven Martin Jacobson
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Patent number: 10052281Abstract: A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading enzyme of substance P, is administered locally in a dosage not influencing blood pressure, and a pharmaceutical for improving dysphagia containing the composition.Type: GrantFiled: May 8, 2017Date of Patent: August 21, 2018Assignee: Meiji Seika Pharma Co., Ltd.Inventors: Koichi Kitamura, Maho Kondo, Kiyoshi Shimoyama, Toru Kurosawa
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Patent number: 10052282Abstract: A pet hydration system comprising of specific ranges of vitamins and minerals conducive to a pet's health, with such nutrients placed into a liquid beverage and ultimately dispensed via a compartmentalized beverage dispenser. The compartmentalized beverage dispenser is formed such that separate liquids are measured out and dispensed to the pet in a manner that the pet receives the optimal amount of nutrition.Type: GrantFiled: September 23, 2016Date of Patent: August 21, 2018Inventor: Sydney Baskins
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Patent number: 10052283Abstract: Disclosed is a composition for forming an injectable hydrogel. The composition includes 1% by weight or less of a graphene-based material and 5% by weight or more of a triblock copolymer. The triblock copolymer may be a copolymer represented by Formula 1: wherein n is an integer from 8 to 540, m is an integer from 16 to 70, and R is H or a vinylcarbonyl group (CH2?CHCO—). When R in Formula 1 is a vinylcarbonyl group, the triblock copolymer may be crosslinked through the vinylcarbonyl group to form a nanogel. The composition can be prepared by a simple mixing process. In addition, the composition is substantially free from in vitro and in vivo stability problems encountered with conventional hydrogel compositions. Furthermore, the composition has high biocompatibility as well as excellent mechanical properties such as high storage modulus.Type: GrantFiled: February 19, 2015Date of Patent: August 21, 2018Assignee: Gwangju Institute of Science and TechnologyInventors: Giyoong Tae, Da-ae Won
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Patent number: 10052284Abstract: The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: March 6, 2017Date of Patent: August 21, 2018Assignee: TRANSLATE BIO, INC.Inventors: Michael Heartlein, Daniel Anderson, Yizhou Dong, Frank DeRosa
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Patent number: 10052285Abstract: Cryogranulation systems with improved dispenser assemblies are provided for use in manufacturing frozen pellets of pharmaceutical substances in a fluid medium. Methods of cryogranulating the pharmaceutical substance in the fluid medium are also provided. In particular embodiments, the dispenser assembly is used with suspensions or slurries of pharmaceutical compositions including biodegradable substances, such as proteins, peptides, and nucleic acids. In certain embodiments, the pharmaceutical substance can be adsorbed to any pharmaceutically acceptable carrier particles suitable for making pharmaceutical powders. In one embodiment, the pharmaceutical carrier can be, for example, diketopiperazine-based microparticles. The dispenser assembly improves the physical characteristics of the cryopellets formed and minimizes product loss during processing.Type: GrantFiled: January 17, 2017Date of Patent: August 21, 2018Assignee: MannKind CorporationInventors: Edwin Amoro, Karel Vanackere, Michael A. White
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Patent number: 10052286Abstract: Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.Type: GrantFiled: July 11, 2017Date of Patent: August 21, 2018Assignee: COSMO TECHNOLOGIES LIMITEDInventors: Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
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Patent number: 10052287Abstract: A delivery vehicle comprising a core (1) surrounded by a digestible polymer shell (4) having a melting and/or softening point above the body temperature of an animal or human, wherein said core comprises a lipid and/or lipophilic active ingredient (2) dispersed in a continuous polymer matrix (3). The delivery vehicle can be used to release lipid and/or lipophilic active ingredients, such as pharmaceuticals, nutraceuticals, supplements, traditional/herbal medicine, or combinations thereof, after a predetermined lag time following ingestion.Type: GrantFiled: July 27, 2015Date of Patent: August 21, 2018Assignee: Nestec S.A.Inventors: Timothy James Wooster, Laurence Donato-Capel, Anwesha Sarkar, Simone Acquistapace
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Patent number: 10052288Abstract: The invention relates to a formulation for the delayed and controlled delivery of an adsorbent into the lower intestine of mammals. The formulation includes a carrageenan and an adsorbent, such as activated charcoal. The invention further relates to uses of this formulation, in particular to pharmaceutical uses. In one embodiment, the formulation is used to eliminate or reduce the side effects in the intestine, in particular in the colon, of pharmaceutical agents that are administered as a treatment for a disorder, but that have side effects when they reach the late ileum, the caecum or the colon.Type: GrantFiled: July 5, 2017Date of Patent: August 21, 2018Assignee: DA VOLTERRAInventors: Francois Lescure, Jean De Gunzburg
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Patent number: 10052289Abstract: The present invention relates to a composition comprising at least one active ingredient with low aqueous solubility, said active ingredient being present therein in a form noncovalently associated with nanoparticles formed by at least one POM polymer of formula (I), and in which said active ingredient is present in a proportion of at least 5 ?mol/g of POM. It is also directed towards the use of such nanoparticles, noncovalently associated with an active ingredient, with a view to increasing the aqueous solubilization of said active ingredient.Type: GrantFiled: December 18, 2009Date of Patent: August 21, 2018Assignee: Flamel Ireland LimitedInventors: Rémi Meyrueix, Rafael Jorda, Gauthier Pouliquen, You-Ping Chan, Olivier Breyne
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Patent number: 10052290Abstract: The present invention provides an enteric-coated hemoglobin multiparticulate comprising a core, a hemoglobin formulation coating, an inner or sub-coating, and an enteric coating. The present invention also provides a method of preparing said enteric-coated hemoglobin multiparticulate. The present invention further provides a method for treating various diseases caused by oxygen deficiency comprising administering to a subject said enteric-coated hemoglobin multiparticulate in order to orally deliver the encapsulated hemoglobin-based oxygen carriers to a specific target of said subject in a controlled release manner.Type: GrantFiled: February 4, 2016Date of Patent: August 21, 2018Assignee: Billion King International Ltd.Inventors: Bing Lou Wong, Sui Yi Kwok
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Patent number: 10052291Abstract: The present invention relates to electrospun fibers comprising i) a hydrophilic polymer that is soluble in a first solvent, ii) a bioadhesive substance that is slightly soluble in said first solvent, iii) optionally, a drug substance.Type: GrantFiled: June 9, 2015Date of Patent: August 21, 2018Assignee: DERMTREAT APSInventors: Jens Hansen, Lars Hellerung Christiansen
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Patent number: 10052292Abstract: Systems and methods provide sugar alcohol to heat stressed ruminants to improve performance. During periods of high temperature or humidity, heat stressed ruminants may exhibit decreased dry matter intake, and in response, an effective amount of sugar alcohol such as sorbitol may be provided in the ruminant diet to cause performance to increase, which may include increased milk yield, improved feed efficiency or both compared to heat stressed dairy cattle without sugar alcohol in the diet.Type: GrantFiled: October 26, 2017Date of Patent: August 21, 2018Assignee: PURINA ANIMAL NUTRITION LLCInventors: Bill L. Miller, Jill A. Davidson, Cindie M. Luhman
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Patent number: 10052293Abstract: A Curcumin infused milk beverage composition comprising 0.05% to 0.15% alkalized Curcumin, standardized milk with fat, sugar and stabilizing agents, wherein the pH of resultant composition is maintained at 6.8.Type: GrantFiled: August 31, 2016Date of Patent: August 21, 2018Inventor: Srikumar Misra
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Patent number: 10052294Abstract: Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts of formula (I) and a crystalline form of potassium 2,5-dihydroxybenzenesulfonic acid are provided. Also provided are methods of treating rosacea comprising administering crystalline forms of potassium 2,5-dihydroxybenzenesulfonic acid.Type: GrantFiled: November 23, 2015Date of Patent: August 21, 2018Assignee: AmDerma Pharmaceuticals, LLCInventors: Unni Santhosh, Annadurai Marimuthu Senthilkumar, Bodireddy Mohan Reddy, Rajendran Kamala, Mahender Rao Siripragada
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Patent number: 10052295Abstract: The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy.Type: GrantFiled: January 9, 2017Date of Patent: August 21, 2018Inventor: William A. Shaver
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Patent number: 10052296Abstract: Formulations, methods of manufacturing, methods of stabilizing, kits, and uses as medicament are provided, for example for the treatment of pain. The formulations can comprise gabapentin optionally combined with at least one non-opioid pain drug in an aqueous carrier. The pharmaceutical formulation can have a pH of about 2.0 to about 10.0. The at least one non-opioid pain drug can be acetaminophen. The components can be included in any amount suitable for purposes of obtaining properties desirable for an injectable infusion, for example an intravenous infusion.Type: GrantFiled: April 7, 2017Date of Patent: August 21, 2018Assignee: NEVAKAR INC.Inventors: Varun Khurana, Vivek Yadav, Jack Martin Lipman, Tao Zhang, Iouri V. Ilitchev, Tushar Hingorani, Kumaresh Soppimath, Navneet Puri
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Patent number: 10052297Abstract: The invention relates to the use of L-serine as a drug for preventing and/or treating an inflammatory response of the skin caused by the overexpression and/or the overactivation of PAR2 receptors.Type: GrantFiled: July 1, 2010Date of Patent: August 21, 2018Assignee: PIERRE FABRE DERMO-COSMETIQUEInventors: Corinne Dechelette, Nathalie Castex Rizzi, Laetitia Bonzom
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Patent number: 10052298Abstract: The invention provides a method of increasing blood flow in a subject in need of increased blood flow by administering citrulline or a salt thereof and arginine or a salt thereof to the subject.Type: GrantFiled: March 9, 2017Date of Patent: August 21, 2018Assignees: Kyowa Hakko Bio Co., Ltd., National University Corporation Nagoya UniversityInventors: Masayuki Ochiai, Koji Morishita, Toshio Hayashi
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Patent number: 10052299Abstract: Some aspects of the invention provide for essential fatty acids which are substituted in specific positions to slow down oxidative damage by Reactive Oxygen Species (ROS), and to suppress the rate of consequent formation of reactive products, for the purpose of preventing or reducing the damage associated with oxidative stress associated diseases such as neurological diseases and age-related macular degeneration (AMD).Type: GrantFiled: October 29, 2010Date of Patent: August 21, 2018Assignee: Retrotope, Inc.Inventor: Mikhail S. Shchepinov
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Patent number: 10052300Abstract: The present disclosure relates to methods and compositions for suppressing the growth of fungus on selected areas of the skin. A composition for suppressing deep seated fungal growth comprising conjugated linoleic acid, Punicic acid, or combination thereof, and niacinamide and L-aspartic acid is provided herein. Methods of making and using the composition are also presently provided.Type: GrantFiled: October 19, 2017Date of Patent: August 21, 2018Inventor: David Changaris
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Patent number: 10052301Abstract: The present invention provides a method for treating a cancer in a subject involving administering to the subject a compound of formula (II) or (II?): wherein R1, R2, R3, R4, R5, R6 and R7 are independently H, OH, alkoxy or alkylcarbonyloxy, or a pharmaceutically acceptable salt thereof. Also provided is a compound of formula (II) or (II)?, wherein R1 and R2 are independently OH, alkoxy or alkylcarbonyloxy, R3 and R4 are independently H, OH, alkoxy or alkylcarbonyloxy, R6 is H, alkoxy or alkylcarbonyloxy, R5 is H, OH or alkylcarbonyloxy, R6 is H or alkoxy, and R7 is H, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 17, 2015Date of Patent: August 21, 2018Assignee: ORX PHARMACEUTICAL CORPORATIONInventor: Alexander MacGregor
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Patent number: 10052302Abstract: The green synthesis of a reduced graphene oxide (rGO) silica (SiO2) nanocomposite using Nigella sativa seed extract includes mixing a quantity of carbon source in an acid solution while stirring to obtain a solution; adding a first oxidant gradually into the solution to oxidize the soot and obtain a first suspension; stirring the first suspension while maintaining a temperature of the suspension to about 35° C.; adding plant seeds extract to the first suspension while raising the temperature of the suspension to about 60° C.; adding a second oxidant to the suspension to form the reduced graphene oxide nanoparticles; isolating the reduced graphene oxide nanoparticles by centrifugation; suspending the reduced graphene oxide nanoparticles in water; adding a solution comprising tetraethyl orthosilicate (TEOS), concentrated aqueous ammonia solution and a plant seeds extract under ultrasonication; and increasing the temperature to about 90° C. to form reduced graphene oxide-silicon dioxide nanocomposite suspension.Type: GrantFiled: May 10, 2016Date of Patent: August 21, 2018Assignee: KING SAUD UNIVERSITYInventors: Manal Ahmed Gasmelseed Awad, Awatif Ahmed Hendi, Khalid Mustafa Osman Ortashi, Amel Laref
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Patent number: 10052303Abstract: The present invention provides stable, fast-acting liposomal and micelle formulations of cannabinoids that are suitable for pharmaceutical and nutraceutical applications.Type: GrantFiled: August 3, 2015Date of Patent: August 21, 2018Assignee: TEEWINOT TECHNOLOGIES LIMITEDInventor: Robert Winnicki
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Patent number: 10052304Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.Type: GrantFiled: October 12, 2016Date of Patent: August 21, 2018Assignee: University of Iowa Research FoundationInventors: Bryan G. Allen, Douglas R. Spitz, Garry R. Buettner, Joseph Cullen, Joshua Schoenfeld, Michael Schultz, Fenghuang Zhan
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Patent number: 10052305Abstract: In various embodiments methods and composition are provided for the treatment and/or prophylaxis of cystinuria. In certain embodiments the methods involve administering to a mammal in need thereof (e.g., identified as at risk for, or having cystinuria) an effective amount of lipoic acid and/or one or more lipoic acid derivatives.Type: GrantFiled: October 3, 2016Date of Patent: August 21, 2018Assignee: BUCK INSTITUTE FOR RESEARCH ON AGINGInventors: Tiffany Zee, Marshall L. Stoller, Pankaj Kapahi
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Patent number: 10052306Abstract: Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed.Type: GrantFiled: November 23, 2016Date of Patent: August 21, 2018Assignee: CADENT THERAPEUTICS, INC.Inventors: David R. Anderson, Robert A. Volkmann, Frank S. Menniti
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Patent number: 10052307Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: GrantFiled: May 8, 2015Date of Patent: August 21, 2018Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y Ying, Joo Eun Chung, Ki Hyun Bae, Min-han Tan, Esther Lee
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Patent number: 10052308Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.Type: GrantFiled: October 28, 2016Date of Patent: August 21, 2018Assignee: Aptinyx Inc.Inventors: John A. Lowe, III, M. Amin Khan
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Patent number: 10052309Abstract: The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.Type: GrantFiled: August 31, 2017Date of Patent: August 21, 2018Assignees: University of South Florida, Torrey Pines Institute for Molecular StudiesInventors: Lindsey Neil Shaw, Renee Marie Fleeman, Richard Allen Houghten, Marcello Angelo Giulianotti, Radleigh G. Santos, Adel Nefzi
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Patent number: 10052310Abstract: In some embodiments, the present disclosure pertains to compositions with compounds that inhibit Separase activity. In additional embodiments, the present disclosure pertains to methods of treating a tumor in a subject by administering one or more compositions of the present disclosure to the subject.Type: GrantFiled: October 20, 2014Date of Patent: August 21, 2018Assignee: BAYLOR COLLEGE OF MEDICINEInventors: Debananda Pati, Nenggang Zhang
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Patent number: 10052311Abstract: The invention relates to the use of a pan-PPAR agonist, or of a pharmaceutical composition containing said agonist, for the treatment of a fibrotic condition.Type: GrantFiled: June 12, 2015Date of Patent: August 21, 2018Assignee: INVENTIVAInventors: Irena Konstantinova, Jean-Michel Luccarini, Jean-Louis Junien, Pierre Broqua
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Patent number: 10052312Abstract: The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.Type: GrantFiled: March 2, 2017Date of Patent: August 21, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Alexandros Vakalopoulos, Markus Follmann, Ingo Hartung, Philipp Buchgraber, Rolf Jautelat, Jorma Haβfeld, Niels Lindner, Alexey Gromov, Frank Wunder, Johannes-Peter Stasch, Gorden Redlich, Volkhart Min-Jian Li, Eva Maria Becker-Pelster, Andreas Knorr
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Patent number: 10052313Abstract: The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine and a polyol. The compositions optionally contain a cycloplegic agent, a surfactant, a viscosity enhancer, an osmolarity modifier and a preservative.Type: GrantFiled: August 12, 2016Date of Patent: August 21, 2018Assignee: PRESBYOPIA THERAPIES, LLCInventors: Gerald Horn, Lee Nordan
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Patent number: 10052314Abstract: Described herein are methods of treating non-metastatic castrate-resistant prostate cancer with anti-androgens.Type: GrantFiled: December 21, 2017Date of Patent: August 21, 2018Assignee: Aragon Pharmaceuticals, Inc.Inventor: Isan Chen
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Patent number: 10052315Abstract: Provided herein are lyophilized formulations of 2-(4-chlorophenyl)-N-((2-(2,6 -dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof. Methods of using the formulations and dosage forms for treating, managing, and/or preventing cancer are also provided herein.Type: GrantFiled: January 6, 2017Date of Patent: August 21, 2018Assignee: Celgene CorporationInventors: Ho-Wah Hui, Yu Pu
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Patent number: 10052316Abstract: The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In various aspects, the present invention comprises administering one or more compounds selected from the group consisting of epicatechin, an epicatechin derivative, catechin, a catechin derivative, nicorandil, and a nicorandil derivative in an amount effective to ameliorate mitochondrial toxicity caused by administration of a chemical, food, or drug.Type: GrantFiled: June 5, 2012Date of Patent: August 21, 2018Assignee: Cardero Therapeutics, Inc.Inventors: Francisco Villarreal, Alan Maisel, George Schreiner, Guillermo M. Ceballos Reyes, Pam Taub
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Patent number: 10052317Abstract: The invention provides a neurokinin 3 receptor (NKR3) antagonist for use in the treatment, prevention or amelioration of hot flushes in a human subject, for example a menopausal woman or a patient undergoing cancer therapy which affects secretion of sex steroids. The invention also provides a NKR3 antagonist together with a further active agent, and a composition and a kit comprising a NKR3 antagonist and a further active agent. The invention further provides a NKR3 agonist or exogenous NKB for the induction of hot flushes in a human subject.Type: GrantFiled: September 5, 2014Date of Patent: August 21, 2018Assignee: Imperial Innovations LimitedInventors: Waljit Dhillo, Channa Jayasena
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Patent number: 10052318Abstract: Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. Also provided are methods of enhancing the activity of a serotonin reuptake inhibitor (SRI) comprising co-administering a glutamate modulator and a serotonin reuptake inhibitor. Pharmaceutical composition comprising a serotonin reuptake inhibitor and a glutamate modulator are also provided.Type: GrantFiled: May 15, 2014Date of Patent: August 21, 2018Assignee: YALE UNIVERSITYInventors: Vladimir Coric, John H. Krystal, Gerard Sanacora
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Patent number: 10052319Abstract: The present invention relates to a medicament comprising lurasidone or a pharmaceutically acceptable acid addition salt thereof for treating pervasive developmental disorders and a method of the treatment thereof.Type: GrantFiled: March 14, 2013Date of Patent: August 21, 2018Assignee: SUMITOMO DAINIPPON PHARMA CO., LTD.Inventor: Tsuyoshi Tsujimura
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Patent number: 10052320Abstract: The invention relates to new quinoxaline derivative compounds of formula (I), to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.Type: GrantFiled: February 3, 2016Date of Patent: August 21, 2018Assignee: ASTEX THERAPEUTICS LTDInventors: Steven John Woodhead, Christopher William Murray, Valerio Berdini, Gordon Saxty, Gilbert Ebai Besong, Lieven Meerpoel, Olivier Alexis Georges Querolle, Virginie Sophie Poncelet