Patents Issued in October 25, 2018
  • DENTAL COMPOSITION
    Publication number: 20180303722
    Abstract: The present invention relates to a dental composition comprising a specific polymerization initiator system comprising a compound having an acylsilyl- or acylgermanyl-group. The present invention also relates the use of the compound having an acylsilyl- or acylgermanyl group for the preparation of a dental composition.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 25, 2018
    Applicant: DENTSPLY SIRONA Inc.
    Inventors: Joachim E. KLEE, Florian SZILLAT, Maximilian MAIER, Helmut RITTER, Jacques LALEVEE, Jean Pierre FOUASSIER, Fabrice MORLET-SAVARY, Celine DIETLIN, Mariem BOUZRATI-ZERELLI, Christoph P FIK
  • PROCESS FOR THE GENERATIVE PRODUCTION OF DENTAL MOLDINGS
    Publication number: 20180303723
    Abstract: The invention relates to a method for generatively producing a dental molding for at least one of dental restoration and dental prostheses. The method comprises the following steps: a) providing at least one layer of a dispersion, particularly an aqueous dispersion, wherein the dispersion comprises at least one binder, and wherein the dispersion comprises ceramic particles and/or glass ceramic particles and/or powder metal particles; b) applying hardeners to the layer of dispersion in places for activating the at least one binder for hardening the layer of the dispersion in places, whereby a rough blank is obtained, particularly a green body, wherein at least two hardeners having different material composition from each other are used; and c) sintering the rough blank into the dental molding.
    Type: Application
    Filed: March 21, 2018
    Publication date: October 25, 2018
    Inventor: Stefan Köbel
  • EXTERNAL PREPARATION FOR SKIN OR PASTE INCLUDING AEROGEL HAVING BOTH HYDROPHILICITY AND HYDROPHOBICITY
    Publication number: 20180303724
    Abstract: An external preparation for skin and an aerogel paste are provided. The external preparation for skin comprises aerogel powder and a solvent. The aerogel powder includes a mixture of aerogel particles having a hydrophilic functional group on a surface thereof and aerogel particles having a hydrophobic functional group on a surface thereof. The hydrophilic functional group is a hydroxy group, and the hydrophobic functional group is hydrogen, a C1 to C18 alkyl group, a silyloxy group represented by the following Chemical Formula 1, or a combination thereof: [Chemical Formula 1] *—OSiH(3-n)R1n wherein R1 is a C1 to C18 alkyl group, n is an integer ranging from 0 to 3, and * denotes a bond.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Applicant: Industry-University Cooperation Foundation Hanyang University
    Inventor: Tae-Won KIM
  • CUSTOMIZABLE DISSOLVABLE OBJECTS AND RELATED METHODS OF MANUFACTURE
    Publication number: 20180303725
    Abstract: The present disclosure is directed to dissolvable objects that are configurable. The dissolvable objects are dissolvable in a solvent, such as water in a bath tub. The dissolvable objects are further configured to receive a seletable additive, which can be an insertion of another object and/or liquid. The present disclosure is also directed to methods of manufacturing dissolvable objects that are configurable.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 25, 2018
    Inventor: Robert Nathan Alder
  • BIOTECHNOLOGICALLY-PRODUCED CELLULOSE-CONTAINING ARTICLE FOR DERMATOLOGICAL USE
    Publication number: 20180303726
    Abstract: A cellulose-containing article for treating an area of skin, wherein the article—comprises BNC in an amount of at least 1% by weight and at most 15% by weight, —comprises fluid in an amount of at least 85% by weight and at most 99% by weight, —has an average thickness of at least 0.5 mm and at most 8 mm, wherein the BNC is of microbial origin.
    Type: Application
    Filed: September 27, 2016
    Publication date: October 25, 2018
    Inventor: Nadine HESSLER
  • TEXTURED COMPOSITIONS
    Publication number: 20180303727
    Abstract: The present invention describes compositions which form particular textures in oil-in-water systems and aqueous systems and are used especially in the preparation of cosmetic products.
    Type: Application
    Filed: October 31, 2016
    Publication date: October 25, 2018
    Inventors: Heidi RIEDEL, Bjoern KLOTZ, Robert JUNG
  • A TWO-PART COSMETIC COMPOSITION FOR CHANGING COLOR OF KERATINIC FIBERS
    Publication number: 20180303728
    Abstract: The present disclosure relates to a two-part cosmetic composition for changing color of keratinic fibers, comprising (a) a gel-like part containing optionally an oxidative dye precursor, and a thickener selected from the group of xanthan gum, anionic amphiphilic polymer, and combination thereof, and (b) an oxidizing part containing an oxidizing agent, and a thickener including one or more anionic amphiphilic polymers.
    Type: Application
    Filed: November 27, 2015
    Publication date: October 25, 2018
    Applicant: Henkel AG & Co. KGaA
    Inventor: Congying Liu
  • DENTIFRICE COMPOSITIONS HAVING IMPROVED AESTHETICS
    Publication number: 20180303729
    Abstract: Dentifrice composition comprising at least one phase containing activated carbon and interference pigment.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 25, 2018
    Inventor: Zhisheng CHEN
  • COMPOSITION HAVING A COLOUR TRANSFORMATION DURING APPLICATION
    Publication number: 20180303730
    Abstract: A composition comprising a specific combination of surfactants, greater than or equal to 10% by weight of C1-C4 alcohol; and at least one solid fatty alcohol, can be used in caring for keratin materials, in particular the skin and lips.
    Type: Application
    Filed: December 18, 2015
    Publication date: October 25, 2018
    Applicant: L'OREAL
    Inventors: Yangdong CHEN, Thierry COTTON
  • NOVEL COMPOSITIONS
    Publication number: 20180303731
    Abstract: The invention provides a topical o/w emulsion which moisturizes, and protects, repairs or restores the skin lipid barrier of a mammal. The topical o/w emulsion composition comprises: a) a discontinuous oil phase; b) a continuous aqueous phase comprising water; c) a thickening agent; d) at least one lamellar membrane structure comprising (i) a phospholipid, (ii) a fatty alcohol, and (iii) a fatty acid; e) a pharmaceutically acceptable active agent; and f) optionally a dermatologically acceptable excipient. In one embodiment, the composition, in use, has a water vapor transmission rate of less than or about 75 g·m?2·hr?1 measured in vitro using the modWVTR test methodology.
    Type: Application
    Filed: March 9, 2018
    Publication date: October 25, 2018
    Inventors: Pallav Arvind BULSARA, Martyn J. Clarke, Dara Lisa Dinner, Alireza Shalviri
  • BIODEGRADABLE COATINGS AND PAINTS
    Publication number: 20180303732
    Abstract: Disclosed herein are biodegradable coating and paint compositions comprising 1,3-propanediol, wherein the 1,3-propanediol in said biodegradable composition has a bio-based carbon content of about 1% to 100%. In addition, it is preferred that the 1,3-propanediol be biologically-derived, and wherein upon biodegradation, the biologically-derived 1,3-propanediol contributes no anthropogenic CO2 emissions to the atmosphere.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 25, 2018
    Applicant: DuPont Tate & Lyle Bio Products Company, LLC
    Inventors: Ann Wehner, Gyorgyi Fenyvesi, Carl F. Muska, Joseph W. DeSalvo, Melissa Joerger, Robert Miller, Irwin A. Palefsky, Raja Hari Poladi
  • COSMETIC COMPOSITION FOR ANTI-AGING OR ALLEVIATING SKIN REDNESS, AND MEDICINAL COMPOSITION FOR PREVENTING AND TREATING SKIN INFLAMMATORY DISEASES, CONTAINING COMPOUND INDUCING INCREASE IN EXPRESSION OF ADIPONECTIN
    Publication number: 20180303733
    Abstract: Provided are a cosmetic composition for anti-aging or alleviating skin redness, and a medicinal composition for treating and preventing skin inflammatory diseases caused by light, containing a compound inducing an increase in expression of adiponectin or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 20, 2018
    Publication date: October 25, 2018
    Inventors: Kee Don PARK, Hwa-Jee CHUNG, Heung Jae KIM, Chae Jin LIM, Seok Jeong YOON, Jong Phill KANG, Seon Deok KWON, Myung Ho KOR, Ju Yeon JUNG, Beom Cheol KIM, Ka Young SHIN
  • COMPOSITION FOR SKIN WHITENING COMPRISING AMORPHIGENI AS EFFECTIVE INGREDIENT
    Publication number: 20180303734
    Abstract: A skin whitening composition includes amorphigeni or a salt thereof as an effective ingredient. Amorphigeni suppresses the expression of tyrosinase and induces autophagy on melanosomes. As such, it was confirmed that amorphigeni not only suppresses melanin production but also exhibits the effect of removing melanin previously produced by ?-MSH (melanocyte-stimulating hormone). Accordingly, amorphigeni can be advantageously used as a functional material for skin whitening and skin lightening.
    Type: Application
    Filed: October 13, 2016
    Publication date: October 25, 2018
    Inventors: Kwang Dong KIM, Ji Yun YOO, Soojong PARK, Sangseok OH, Dae Wook KIM, Ki Hun PARK, Kiwon LEE
  • COSMETIC COMPOSITIONS COMPRISING HYALURONAN BIOSYNTHESIS PROMOTING AGENTS
    Publication number: 20180303735
    Abstract: A cosmetic composition, including compounds of formula (I) in which R and R? independently of one another denote hydrogen, hydroxyl, a linear or branched OC1-C4-alkyl group, or optionally R and R? form together a methylenedioxy group resulting in a 3,4-methylendioxyphenyl residue and R? denotes a linear or branched C1-C9 alkyl group or A, in which A denotes with X, Y and Z being independently of one another hydrogen, hydroxyl, an linear or branched C1-C4-alkyl group, or a linear or branched OC1-C4-alkyl group.
    Type: Application
    Filed: April 24, 2018
    Publication date: October 25, 2018
    Inventors: Martina Herrmann, Gerhard Schmaus
  • NOVEL OCCLUSIVE FORMULATIONS
    Publication number: 20180303736
    Abstract: The invention provides a topical o/w emulsion which moisturizes, and protects, repairs or restores the skin lipid barrier of a mammal. The topical o/w emulsion composition comprises a discontinuous oil phase; a continuous aqueous phase comprising water; a thickening agent; at least one lamellar membrane structure comprising a phospholipid, a fatty alcohol, and a fatty acid; and wherein in use the composition has a water vapor transmission rate of less than about 70 g·m?2·hr?1 measured in vitro using the modWVTR test methodology.
    Type: Application
    Filed: October 25, 2016
    Publication date: October 25, 2018
    Inventors: Pallav Arvind BULSARA, Martyn J. CLARKE, Anthony V. RAWLINGS
  • HAIR RESTORATION AND/OR HAIR GROWTH PROMOTING COMPOSITION CONTAINING SOYASAPONIN
    Publication number: 20180303737
    Abstract: The present invention relates to a composition for improving scalp condition and/or promoting hair restoration containing soyasaponin or a derivative thereof, which can be widely used as an external skin preparation for improving scalp condition and/or promoting hair growth and hair restoration, a cosmetic composition or a pharmaceutical composition, as the composition has high stability for skin without side effects, improves a scalp condition, and is effective in promoting hair growth and/or preventing hair loss by activating stem cells.
    Type: Application
    Filed: September 29, 2016
    Publication date: October 25, 2018
    Inventors: Young Gyu KANG, Jae Young KO, Jun Seong PARK
  • USE OF GLYCOSIDES TO INCREASE HAIR MASS
    Publication number: 20180303738
    Abstract: This invention relates to the cosmetic use of at least one glycoside chosen from glycosides having the following general formula (I): Sacc-(CH2)i—X—R in order to increase the hair mass.
    Type: Application
    Filed: October 20, 2016
    Publication date: October 25, 2018
    Inventors: Sébastien THIBAUT, Maria DALKO
  • COSMETIC COMPOSITION INCLUDING WATER SOLUBLE SCRUB PARTICLES CONTAINING POLYPEPTIDE AND/OR CELL CULTURE
    Publication number: 20180303739
    Abstract: The present invention relates to a non-aqueous cosmetic composition comprising water-soluble scrub particles containing a polypeptide or a cell culture component. More specifically, the present invention relates to a non-aqueous cosmetic composition comprising 0.01 wt % to 15 wt % of hard and angulated water-soluble scrub particles containing cell culture components or various polypeptides including a peptide and an oligopeptide. Further, the cosmetic composition of the present invention provides a non-aqueous cosmetic composition which does not comprise active ingredients, but comprises water-soluble excipient scrub particles for maintaining or improving a scrubbing effect and adjusting viscosity or volume.
    Type: Application
    Filed: October 13, 2016
    Publication date: October 25, 2018
    Inventors: Kyuboem HAN, Seong Soo JEON, Jongcheon HA
  • ORAL CARE PRODUCTS AND METHODS COMPRISING HLPS
    Publication number: 20180303740
    Abstract: Provided herein are oral care compositions comprising Hydrophobin-like proteins (HLPs), which are useful in methods of repairing or inhibiting dental erosion, promoting dental remineralization, and/or enhancing the anti-cavity effects of fluoride.
    Type: Application
    Filed: October 25, 2016
    Publication date: October 25, 2018
    Inventors: Nina Schneider, Thomas Subkowski, Stefan Jenewein, Marvin Karos, Claus Bollschweiler, Volker Wendel, Jianhong Qiu, LaTonya Kilpatrick-Liverman, Lynette Zaidel, Melanie Melcher, Thorsten Henkes, Sandra Facey, Bernhard Hauer
  • COMBINATION OF N-ACYLDIPEPTIDE DERIVATIVES AND RETINOL, AND METHODS OF USE THEREOF
    Publication number: 20180303741
    Abstract: Methods of treating aging related skin changes and of increasing skin thickness with topical administration of N-acyldipeptide derivatives and retinol are described. Combinations of retinol and N-acyldipeptide derivatives, are therapeutically effective for increasing skin thickness, and for treating extrinsic and intrinsic aging and aging related skin changes, such as fine lines, wrinkles, photoaging, hyperpigmentation, laxity, age spots, lentigines, mottled skin, and cellulite.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 25, 2018
    Inventors: Ruey J. YU, Eugene J. VAN SCOTT
  • CROSS LINKED SILK-HYALURONIC ACID COMPOSITION
    Publication number: 20180303742
    Abstract: Compositions useful as dermal fillers and methods using such compositions to treat various skin and soft tissue conditions. The dermal fillers can comprise silk attached to hyaluronic acid using for example two cross linkers and can be used to treat of facial imperfections, facial defects, facial augmentations, breast imperfections, breast augmentations or breast reconstructions.
    Type: Application
    Filed: June 29, 2018
    Publication date: October 25, 2018
    Inventors: Elizabeta Pavlovic, Monica A. Serban, Xiaojie Yu, Nicholas J. Manesis
  • NOVEL RECOMBINANT HIGH-STABILITY SUPEROXIDE DISMUTASE AND APPLICATION THEREOF
    Publication number: 20180303743
    Abstract: The invention discloses a novel high-temperature resistant superoxide dismutase (SOD) and a coding gene and application thereof. The superoxide dismutase has a very high stability and activity under various severe conditions such as high temperature, high acidity or alkalinity and various proteases such as pepsin and trypsin. The superoxide dismutase of the present invention overcomes the problems of the existing SOD products, such as unstability, low in activity or even a complete lack of activity and prone to degradation and inactivation in the digestive tract. And the superoxide dismutase of the present invention is expected to be developed into cosmetics or health-care foods or to medicines which are stable in activity and have a good effect.
    Type: Application
    Filed: December 26, 2016
    Publication date: October 25, 2018
    Inventor: Fanguo Meng
  • COSMETIC COMPOSITION COMPRISING POLYURETHANE
    Publication number: 20180303744
    Abstract: A cosmetic composition comprises at least one water-dispersible polyurethane polymer obtainable by the reaction of at least one isocyanate-functional polyurethane pre-polymer A) with at least one isocyanate-reactive component B), wherein the at least one isocyanate-functional polyurethane pre-polymer A) is obtainable by the reaction of at least one polyol component A1), and at least one polyisocyanate component A2) comprising 60 wt % or more, based on the total weight of polyisocyanates in the pre-polymer formation reaction, of at least one saturated cycloaliphatic polyisocyanate, and wherein the molar ratio of the isocyanate groups to the isocyanate-reactive groups in the pre-polymer A) formation reaction is at least 1.90. The composition provides improved durability and holding power under high humidity conditions and reduced flake formation during combing.
    Type: Application
    Filed: October 30, 2015
    Publication date: October 25, 2018
    Inventors: Sebastian DÖRR, Sophie VIALA, Xiaohui XIONG
  • COMPOSITION FOR FORMING A FILM ON KERATIN FIBRES
    Publication number: 20180303745
    Abstract: A composition for providing a film on keratin fibres, the composition comprising an aminosilicone polymer; a silicone resin which is a MQ resin; a thickening system comprising a thickening polymer; water; one or more pigments or one or more coloured materials; wherein when drying the composition spread with an average wet thickness of 37 micron the fluidity factor is measured to form a drying curve of fluidity factor over time, wherein the fluidity factor is within the range of 10 Hz to 0.001 Hz within the first 15 minutes of drying and the fluidity factor reduces by at least a factor of 100 within the first 15 minutes of drying; wherein the drying curve of fluidity factor over time is measured according to the fluidity factor measurement method and at 23° C. and ambient conditions. Also associated methods, kits and uses.
    Type: Application
    Filed: June 28, 2018
    Publication date: October 25, 2018
    Inventors: Mathias Kurt Herrlein, Ilaria Ambrogio, Matthias Morand, Tatjana Schaefer, Andreas Flohr, Marianna Forgione, Matija Crne, Yonas Gizaw, Ursula Christina Glaser
  • TREATMENT FOR SCALP DRYNESS AND CURLY HAIR
    Publication number: 20180303746
    Abstract: A treatment for scalp dryness and curly hair including a shampoo composition, a conditioning composition and a moisturizing composition. The shampoo composition including about 5-50% by weight of a surfactant, at least 2% amino acids, about 5-15% by weight of an alcohol, and the remainder water. The conditioning composition including about 3%-15% by weight of a fatty alcohol, about 0.1-15% by weight of a conditioning agent, and the remainder water. The moisturizing lotion composition including about 0.1-12% by weight of an alcohol, about 0.1-10% by weight of a conditioning agent, and the remainder water.
    Type: Application
    Filed: January 30, 2018
    Publication date: October 25, 2018
    Applicant: LivSo, LLC
    Inventor: Shari HICKS-GRAHAM
  • SCALP RELIEVING MIXTURE AND SPRAY
    Publication number: 20180303747
    Abstract: A scalp relieving mixture and spray to alleviate pain on an individual's scalp associated with managing, manipulating, and styling hair on the individual's scalp. The scalp relieving mixture and spray includes pure essential oils from the group consisting of clove bud oil, lavender oil, lemongrass oil, peppermint oil, and tea tree oil, Aloe Vera gel, and distilled water.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 25, 2018
    Inventor: Charlotte Higginbotham - Van Horn
  • MASCARA MIXTURE
    Publication number: 20180303748
    Abstract: The present disclosure relates to methods of preparing cosmetic compositions by mixing together two different mascara formulations. The starting mascara formulations may contain the same or different ingredients, and they may differ in viscosity and/or in the melting points of their ingredients, such as their waxes.
    Type: Application
    Filed: April 25, 2018
    Publication date: October 25, 2018
    Inventors: David Chant, Giacomo Marchetti
  • COSMETIC USE OF EXTRACTS DERIVED FROM SOMATIC EMBRYO ENRICHED PLANT CELL CULTURES AND COSMETIC COMPOSITIONS CONTAINING THOSE EXTRACTS
    Publication number: 20180303749
    Abstract: The present invention refers to a method for obtaining plant cell cultures, enriched of somatic embryos, a method of preparation of the extracts derived from these cell cultures, and the use of the obtained extracts in cosmetic compositions, targeted to treat imperfections related to skin aging and for inducing a skin tissue rejuvenation effect.
    Type: Application
    Filed: April 18, 2016
    Publication date: October 25, 2018
    Applicant: VITALAB S.R.L.
    Inventors: Annalisa Tito, Ani Barbulova, Marida Bimonte, Fabio Apone, Gabriella Colucci
  • Scavenging Dissolved Oxygen Via Acoustic Droplet Vaporization
    Publication number: 20180303750
    Abstract: Methods and compositions for treating a patient for a condition characterized by an excess blood concentration of dissolved gas in at least one targeted region of the patient are provided. The method comprises administering a composition comprising a perfluorocarbon droplet emulsion into the blood of the patient; insonifying the at least one target region sufficient to achieve formation of microbubbles by droplet vaporization of at least a portion of the perfluorocarbon droplets present in the blood; whereby a concentration gradient favoring movement of gas molecules from the blood into the microbubbles is established for a time frame.
    Type: Application
    Filed: August 26, 2016
    Publication date: October 25, 2018
    Inventors: Kirthi Radhakrishnan, Christy K. Holland, Kevin J. Haworth
  • PROCESS FOR MAKING CONTROLLED RELEASE MEDICAL IMPLANT PRODUCTS
    Publication number: 20180303751
    Abstract: A method (and the resulting product) of making a medical implant device for releasing self-contained drugs on a controlled basis wherein the method utilizes, at least in part, computer-controlled 3-D printing equipment to deposit via nozzles portions of one or more layers of the medical implant product. The implant has an outer impervious coating, an inner matrix core, an opening and an optional bonding layer.
    Type: Application
    Filed: June 28, 2018
    Publication date: October 25, 2018
    Inventor: Robert W. ADAMS
  • IMPLANTS WITH CONTROLLED DRUG DELIVERY FEATURES AND METHODS OF USING SAME
    Publication number: 20180303752
    Abstract: Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
    Type: Application
    Filed: March 20, 2018
    Publication date: October 25, 2018
    Inventor: David S. Haffner
  • TARGETED DELIVERY OF SPRAY-DRIED FORMULATIONS TO THE LUNGS
    Publication number: 20180303753
    Abstract: Disclosed are inhalation formulations of dry powders comprising particles and processes which yield particles to effectively bypass unwanted deposition in the mouth and throat. Embodiments of the invention are characterized by an inertial parameter which provide an in vitro total lung dose of greater than 80% of a nominal dose. Embodiments of formulations include neat formulations containing active agent only; formulations of active agent and buffer; and formulations comprising active agent, a glass-forming, and/or a shell-forming excipient. Also provided are methods for making the dry powder formulations. The powder formulations are useful for the treatment of diseases and conditions especially respiratory diseases and conditions.
    Type: Application
    Filed: September 7, 2016
    Publication date: October 25, 2018
    Inventors: Keith Try UNG, Jeffry G. WEERS, Daniel HUANG, Nagaraja RAO, Yoen-Ju SON
  • PHARMACEUTICAL COMPOSITIONS OF IL-2
    Publication number: 20180303754
    Abstract: The invention relates to a liquid pharmaceutical composition of I1-2 and its use in the treatment of auto-immune and inflammatory disorders. Methods for preparing said composition and delivery devices filled with said composition are also described.
    Type: Application
    Filed: October 20, 2016
    Publication date: October 25, 2018
    Applicant: ILTOO PHARMA
    Inventors: Jérémie MARIAU, Michel THIRY
  • Novel Liposomal Formulation for the Oral Hepatic Delivery of Drugs
    Publication number: 20180303755
    Abstract: The present invention relates to liposomal compositions, comprising liposomes containing tetraether lipids (TELs), and further comprising the lipopeptide Myr-HBVpreS/2-48 (Myrcludex B) as part of said liposomes, as well as uses thereof for the prevention or treatment of hepatic disorders or diseases, and/or for the oral hepatic delivery of therapeutic and/or diagnostic agents.
    Type: Application
    Filed: October 11, 2016
    Publication date: October 25, 2018
    Applicant: Universität Heidelberg
    Inventors: Gert Fricker, Walter Mier, Frieder Helm, Philipp Uhl, Stephan Urban
  • METHOD OF MAKING DIALKYL SULFOSUCCINATE COMPOSITIONS
    Publication number: 20180303756
    Abstract: A particulate solid composition comprises a blend of dialkyl sulfosuccinate and a water-soluble polymer. The water-soluble polymer can be a cellulose ether, a polysaccharide, a polyvinyl alcohol homopolymer or copolymer, a polyvinyl pyrrolidone homopolymer or copolymer, a polyvinyl caprolactam polymer or copolymer, a poly(meth)acrylate, a poly(alkylene oxide) graft copolymer, or a combination thereof. The particulate solid composition is free flowing, water-soluble, and dissolves rapidly in water. It can be made by drying a solution of dialkyl sulfosuccinate and a water-soluble polymer. The particulate solid composition can be mixed with organic substances having low water solubility, for example a generic, a biologic, a biosimilar, an excipient, a nutraceutical, a medical diagnostic agent, an agricultural chemical, or a combination thereof, to form water-soluble compositions.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 25, 2018
    Inventors: Eric Saly, Maureen Mackay, Matthias Rischer, Wolfgang Mohr, Lena Kurz
  • ENHANCED ABUSE-DETERRENT FORMULATIONS OF OXYCODONE
    Publication number: 20180303757
    Abstract: The present technology relates to an extended-release solid oral pharmaceutical composition, comprising a cured blend of a melt-extruded first component and a second component, wherein the melt-extruded first component comprises a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof, at least one PEO polymer, and a stabilizing agent; and the second component comprises at least one PEO polymer and an oxidative stabilizing agent. The extended-release pharmaceutical compositions of the present technology provide crush-resistant and abuse-deterrent formulations featuring enhanced heat stability, resistance to drug segregation, and resistance to alcohol-induced dose dumping.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Applicant: KASHIV PHARMA LLC
    Inventors: Siddhartha Banerjee, Navnit H. Shah, Gaurang Patel, Murali Mohan Bommana, Ashish Chatterji, Anita Kumar, Petra Inbar, Furong Liu, Srinivas Kone, Priti L. Jagani, Wantanee Phuapradit
  • CALCIUM CARBONATE GRANULATION
    Publication number: 20180303758
    Abstract: Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
    Type: Application
    Filed: May 11, 2018
    Publication date: October 25, 2018
    Inventors: Kevin W. Lang, James W. Dibble, Raya Levin, Gregory B. Murphy
  • IMPLANTABLE MEDICAL DEVICES FOR EXTENDED RELEASE OF THERAPEUTIC AGENTS
    Publication number: 20180303759
    Abstract: The invention pertains to implantable medical devices for controlled delivery of therapeutic agents. Some devices according to the invention have a titanium reservoir, and a porous titanium oxide based membrane to control the rate of release of the therapeutic agent. The reservoir contains a formulation of the active agent, including a stabilizer for the active agent, wherein the stabilizer is provided in an extended release configuration.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 25, 2018
    Applicant: Nano Precision Medical, Inc.
    Inventor: Wouter Erik Roorda
  • ANTIGEN-SPECIFIC, TOLERANCE-INDUCING MICROPARTICLES AND USES THEREOF
    Publication number: 20180303760
    Abstract: The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes.
    Type: Application
    Filed: July 1, 2018
    Publication date: October 25, 2018
    Inventors: BENJAMIN GEORGE KESELOWSKY, JAMAL LEWIS, ABHINAV ACHARYA, MICHAEL J. CLARE-SALZLER
  • Method of Preparing Highly Stable Microcapsule Powders or Microparticles Containing Fat-Soluble Nutrient Having Increased Double Bonds
    Publication number: 20180303761
    Abstract: The present invention provides a method of preparing highly stable microcapsule powders or microparticles containing a fat-soluble nutrient having multiple double bonds.
    Type: Application
    Filed: October 12, 2015
    Publication date: October 25, 2018
    Inventors: Xinde Xu, Di Zhou, Lihua Zhang, Bin Shao
  • METHOD FOR MANUFACTURING A TRANSDERMAL DEVICE
    Publication number: 20180303762
    Abstract: The invention relates to a method for manufacturing a transdermal patch from a drug-containing web that minimizes waste. The web is a layered composite that includes at least a backing layer and a drug-in-adhesive layer and a first strippable release liner. The web is kiss-cut along intersecting cut lines at least down to the depth of the liner, generally defining the extent of individual transdermal patches. The intersections of the cut lines define small zones that are punched out of the web in a generally star shape. The portions of the web above the liner are peeled away from the liner and transferred to a faster moving second liner so that the patches are now further spaced apart from one another. This second liner is then cut to provide transdermal patches that are mounted to release liners that are substantially broader in extent than the patches themselves.
    Type: Application
    Filed: April 19, 2017
    Publication date: October 25, 2018
    Inventors: SPIROS FOTINOS, JEROME LANGLUME, JEAN PAUL CARAVITA
  • DRY PAD
    Publication number: 20180303763
    Abstract: Provided is a dry pad, including a wound-covering membrane formed by arranging a fiber containing a hydrophilic polymer that is swollen by an exudate secreted from a wound, a hydrophobic polymer, and a dry wound-healing agent that is released through swelling of the hydrophilic polymer and is difficult to store in a liquid phase, and a first release member, which is a support on which the fiber is arranged and which is separated from the wound-covering membrane.
    Type: Application
    Filed: October 17, 2016
    Publication date: October 25, 2018
    Applicant: AMOLIFESCIENCE CO., LTD.
    Inventors: In Yong SEO, Ji Hyun LEE
  • METHOD FOR MANUFACTURING A TRANSDERMAL DEVICE
    Publication number: 20180303764
    Abstract: The invention relates to a method for manufacturing a transdermal patch from a drug-containing web that minimizes waste. The web is a layered composite that includes at least a backing layer and a drug-in-adhesive layer and a first strippable release liner. The web is kiss-cut along intersecting cut lines at least down to the depth of the liner, generally defining the extent of individual transdermal patches. The intersections of the cut lines define small zones that are punched out of the web in a generally star shape. The portions of the web above the liner are peeled away from the liner and transferred to a faster moving second liner so that the patches are now further spaced apart from one another. This second liner is then cut to provide transdermal patches that are mounted to release liners that are substantially broader in extent than the patches themselves.
    Type: Application
    Filed: December 12, 2017
    Publication date: October 25, 2018
    Inventors: SPIROS FOTINOS, JEROME LANGLUME, JEAN PAUL CARAVITA
  • METHOD FOR MAKING A TRANSDERMAL FENTANYL PATCH WITH EVEN DRUG CRYSTAL DISTRIBUTION
    Publication number: 20180303765
    Abstract: Methods of producing a transdermal delivery patches are described comprising the preparation of a uniform suspension of drug particles. A plasticizer is added to the suspension. A solution of an adhesive is add to the suspension to form a drug suspension in the adhesive mixture. The drug suspension is coated on a release liner and all solvents are evaporated to form a solid drug reservoir layer. A medical device for transdermal administration of a drug can include the solid drug reservoir layer. Suitable drugs include fentanyl and sufentanil.
    Type: Application
    Filed: December 12, 2017
    Publication date: October 25, 2018
    Inventors: Spiros Fotinos, Jerome Langlume, Jean Paul Caravita
  • METHOD FOR MAKING A TRANSDERMAL FENTANYL PATCH WITH EVEN DRUG CRYSTAL DISTRIBUTION
    Publication number: 20180303766
    Abstract: Methods of producing a transdermal delivery patches are described comprising the preparation of a uniform suspension of drug particles. A plasticizer is added to the suspension. A solution of an adhesive is add to the suspension to form a drug suspension in the adhesive mixture. The drug suspension is coated on a release liner and all solvents are evaporated to form a solid drug reservoir layer. A medical device for transdermal administration of a drug can include the solid drug reservoir layer. Suitable drugs include fentanyl and sufentanil.
    Type: Application
    Filed: April 20, 2017
    Publication date: October 25, 2018
    Inventors: SPIROS FOTINOS, JEROME LANGLUME, JEAN PAUL CARAVITA
  • TREATMENT OF OXIDATIVE STRESS DISORDERS INCLUDING CONTRAST NEPHROPATHY, RADIATION DAMAGE AND DISRUPTIONS IN THE FUNCTION OF RED CELLS
    Publication number: 20180303767
    Abstract: Methods of treating or suppressing oxidative stress diseases and symptoms related to oxidative stress affecting normal electron flow in the cells or caused by reactive oxygen species with redox-active therapeutics. Use of redox-active therapeutics for the reduction, suppression or treatment of oxidative stress induced by chemical agents such as contrast agents and other nephrotoxic agents, by radiation exposure, and by disruptions in the transport of oxygen to tissues, is disclosed.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 25, 2018
    Applicant: BioElectron Technology Corporation
    Inventor: Guy M. MILLER
  • DESIGN, SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXMIER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
    Publication number: 20180303768
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Application
    Filed: July 2, 2018
    Publication date: October 25, 2018
    Inventors: KATHERINE L. RADTKE, HANNAH PETERS, JOHAN NEYTS, DIRK JOCHMANS, ERIC J. SNIJDER
  • INHIBITION OF MULTIPLE PATHOGENIC AGENTS USING BITHIONOL
    Publication number: 20180303769
    Abstract: Compositions and methods including Bithionol are provided for treating, inhibiting, or preventing caspase-dependent pathogenic agents in a host cell or infected subject. Examples of caspase-dependent pathogenic agents include ricin, anthrax toxin, Botulinum neurotoxin A, diphtheria toxin, Pseudomonas aeruginosa exotoxin A, cholera toxin, Zika virus, and combinations thereof. Compositions and methods also include Bithionol in combination with an antibiotic for more effective clearance of the pathogen and/or toxins.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Applicant: KECK GRADUATE INSTOTUTE OF APPLIED LIFE SCIENCES
    Inventors: Mikhail Martchenko, William Leonardi
  • TREATMENT OF METHYLMALONIC ACIDURIA, ISOVALERIC ACIDURIA, AND OTHER ORGANIC ACIDURIAS WITH TOCOTRIENOL QUINONES
    Publication number: 20180303770
    Abstract: The present invention relates to methods of treating methylmalonic aciduria and other organic acidurias with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.
    Type: Application
    Filed: June 26, 2018
    Publication date: October 25, 2018
    Applicant: BioElectron Technology Corporation
    Inventors: Guy M. MILLER, Carlo DIONISI-VICI, Enrico BERTINI, Diego MARTINELLI
  • INTRAVENOUS ADMINISTRATION OF TRAMADOL
    Publication number: 20180303771
    Abstract: A method of treating pain, e.g., acute post-operative pain, by administering to a human patient(s) a therapeutically effective dose of tramadol intravenously over a prolonged time period is disclosed. In certain embodiments, the dose is intravenously administered in a time period from about 10 minutes to about 3 hours, preferably from about 10 minutes to about 30 minutes. In other embodiments, intravenous doses are administered at suitable time intervals over a time period from about 3 hours to 48 hours.
    Type: Application
    Filed: May 7, 2018
    Publication date: October 25, 2018
    Inventors: S. George KOTTAYIL, Jeffrey H. PING