Abstract: The human eye is constantly in motion. For many imaging applications in the eye, eye motion on the time scale of the image acquisition distorts the images. For imaging applications where the signal is very low, image distortion is so severe that imaging is impossible. According to an exemplary embodiment of the present disclosure, systems, methods and computer-accessible medium can be provided to determine eye motion in real time, and provide real time correction of the eye motion for secondary imaging methods to provide stable images and permit long integration times of single images to increase the signal to noise.

Abstract: A visual field calculation apparatus capable of accurately calculating a visual field range of a user without using a complex configuration is provided. The visual field calculation apparatus includes a saccade detector that detects a saccade on the basis of a first gaze direction detected at a first timing and a second gaze direction detected at a second timing, a saccade speed calculator that calculates speed of the saccade on the basis of a time difference between the first timing and the second timing, the first gaze direction, and the second gaze direction, and a visual field range calculator that calculates a displacement vector of a saccade whose speed exceeds a first threshold, and calculates an area including a final point of the displacement vector as the visual field range of the user.

Abstract: A luminescent ophthalmic device for administering therapeutic materials, the device having at least one luminescent marker disposed in proximity to a therapeutic agent applicator so as facilitate placement in a treatment position when viewed using transcorneal or transpupillary viewing methods.

Abstract: A multimode fundus camera enables three-dimensional and/or spectral/polarization imaging of the interior of the eye to assist in improved diagnosis. In one aspect, the multimode fundus camera includes a first imaging subsystem, a filter module, and a second imaging subsystem. The first imaging subsystem is positionable in front of an eye to form an optical image of an interior of the eye. The filter module is positioned at a pupil plane of the first imaging subsystem or at a conjugate thereof. The second imaging subsystem include a microimaging array and a sensor array. The microimaging array is positioned at the image plane or a conjugate thereof, and the sensor array is positioned at the pupil plane or a conjugate thereof.

Abstract: Radio frequency (RF) energy is transmitted through the application of a RF signal to an external RF energy interface, where the RF signal oscillates at a frequency in an energy transmission band. The transmitted RF energy is received at an implanted medical device, and energy derived from the received RF energy is stored in a direct current (DC) energy storage component of the device. A therapeutic output signal is generated from the stored energy and delivered by the implantable medical device to a patient through one or more electrodes. The therapeutic output signal is configurable to provide either one of RF stimulation therapy and RF ablation therapy, and comprises pulses of an RF signal oscillating at a frequency in a therapy band that is greater than the energy transmission band.

Abstract: During an intraoral scan session, a processing device receives a first intraoral image of a dental site and identifies a candidate intraoral area of interest from the first intraoral image. The processing device receives a second intraoral image of the dental site and verifies the first candidate intraoral area of interest as an intraoral area of interest based on comparison of the second intraoral image to the first intraoral image. The processing device then provides an indication of the intraoral area of interest during the intraoral scan session.

Abstract: Apparatus and methods for hyperspectral imaging analysis that assists in real and near-real time assessment of biological tissue condition, viability, and type, and monitoring the above overtime. Embodiments of the invention are particularly useful in surgery, clinical procedures, tissue assessment, diagnostic procedures, health monitoring, and medical evaluations, especially in the detection and treatment of cancer.

Abstract: A photoacoustic remote sensing system (PARS) for imaging a subsurface structure in a sample has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.

Abstract: A sensor assembly has a flexible body, and a plurality of fiber Bragg gratings (FBG) sensor inserted into the body, the FBG sensor includes an optical fiber extending in a length direction of the body and a plurality of lattices disposed in the optical fiber, a variation of a wavelength spectrum of light, caused by a variation of an interval of the plurality of lattices, is detected, and at least one of force information applied to the body and temperature information of the body is extracted together with refraction information of the body.

Abstract: A biological signal measuring system includes a sensor and a biological signal measuring apparatus configured to calculate a blood refill time of a living tissue of a subject. The sensor includes a pressure applying portion configured to apply pressure on the living tissue, a light emitter configured to emit light toward the living tissue, a light receiver configured to receive reflected light or transmitted light from the living tissue, a first light transmitting member made of a light transmitting material and having one side contacting the light emitter and the other side arranged to contact the subject, a second light transmitting member made of a light transmitting material and having one side contacting the light receiver and the other side arranged to contact the subject, and a light blocking member configured to block light between the light emitter and the light receiver.

Abstract: Presented are embodiments of an apparatus and methodology integrated in the system for non-invasive, continuous, wearable, remote and mobile monitoring of human blood pressure by photoplethysmography (PPG) based sensor and an electronic processing unit with the embedded radio allowing the reading and transmittal of the read blood pressure data to the remote location.

Abstract: This relates to an electronic device with dynamically reconfigurable apertures to account for different skin types, usage conditions, and environmental conditions and methods for measuring the user's physiological signals. The device can include one or more light emitters, one or more light sensors, and a material whose optical properties can be changed in one or more locations to adjust the optical path and the effective separation distances between the one or more light emitters and one or more light sensors or the size, location, or shape of the one or more dynamically reconfigurable apertures. In some examples, the material can be a liquid crystal material, MEMS shutter layer, or light guide, which can form the one or more dynamically reconfigurable apertures. In some examples, the light emitters or light sensors or both can be an array of individually addressable optical components.

Abstract: A system and method for camera-based heart rate tracking. The method includes: determining bit values from a set of bitplanes in a captured image sequence that represent the HC changes; determining a facial blood flow data signal for each of a plurality of predetermined regions of interest (ROIs) of the subject captured by the images based on the HC changes; applying a band-pass filter of a passband approximating the heart rate to each of the blood flow data signals; applying a Hilbert transform to each of the blood flow data signals; adjusting the blood flow data signals from revolving phase-angles into linear phase segments; determining an instantaneous heart rate for each the blood flow data signals; applying a weighting to each of the instantaneous heart rates; and averaging the weighted instantaneous heart rates.

Abstract: A vehicle seat includes sheet-shaped sensors configured to detect electric signals associated with the biopotential of a seated passenger, the vehicle seat being configured to remove noise caused due to static electricity to stably measure a bioelectric signal (e.g., heart rate) of the passenger. A seat back includes the sheet-shaped sensors. A cushion pad placed on a seat back frame is covered with a trim cover. Vertically-extending conductive fabric in a belt shape is disposed on an outer surface of the trim cover. The portion where the conductive fabric is disposed has a three-layer structure of the conductive fabric, a skin, and a wadding. A free end of the conductive fabric drawn into the seat back is provided with a J-hook hooked onto a lower frame bridging portion, thus part of the conductive fabric and the lower frame bridging portion contact each other to be electrically conductive with each other.

Abstract: An embodiment of the disclosure provides a method for measuring change in blood volume using a transcutaneous measurement system applied to a patient's skin. The method involves placing a sensor in contact with the skin of a patient, where the sensor includes a light emitter and a photodetector. An intensity of light emanating from the light emitter is set and an initial intensity of light received at the photodetector is determined, where the light received at the photodetector has traveled through the patient's tissue. A later determination is then made of the intensity of the light received at the photodetector. A change in the blood volume is determined based on the intensity of the light emanating from the light emitter, the initial intensity of light received at the photodetector and the final intensity of light received at the photodetector.

Abstract: An interface for receiving electrical signals representative of a condition of a patient and for conveying representations of the electrical signals to a processing system. The interface includes at least one amplifier circuit configured to alter an amplitude of the electrical signal, a common-mode cancellation amplifier circuit coupled to the at least one amplifier circuit and configured to reduce common-mode signal noise in the electrical signals, and a bootstrap circuit coupled to the at least one amplifier circuit and configured to increase an effective input impedance at an input of the at least one amplifier circuit.

Abstract: Methods and apparatuses, including devices and systems, for remote and detection and/or diagnosis of acute myocardial infarction (AMI). In particular, described herein are handheld devices having an electrode configuration capable of recording three orthogonal ECG lead signals in an orientation-specific manner, and transmitting these signals to a processor. The processor may be remote or local, and it may automatically or semi-automatically detect AMI, atrial fibrillation or other heart disorders based on the analyses of the deviation of the recorded 3 cardiac signals with respect to previously stored baseline recordings.

Abstract: A physiological signal detection clamp for being detachably disposed on a fabric worn by a living body, the physiological signal detection clamp includes: a body, two electrode units, a processing unit and a wireless transmission unit. Each of the two opposite side surfaces of the body has a fixing unit. The body is configured to clamp on the fabric by the two fixing unit. When the body is clamped on the fabric, the sensing surfaces of the two electrode units are correspondingly exposed on the outer side surface of the body and attach to the body surface of the living body for detecting the micro electric signal on the body surface of the living body. The processing unit transfers the micro electric signal detected by the electrode unit into a wireless transmission signal, and the wireless transmission unit outputs the wireless transmission signal.

Abstract: Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.

Abstract: A method and an apparatus for detecting cardiac arrhythmia and a recording medium using the method are provided. In the method, physiological signals of a human comprising a sequence of heart pulses are acquired, and an average of heartbeat intervals between pairs of consecutive heart pulses in the sequence of heart pulses is calculated. Each pair of consecutive heartbeat intervals is examined to identify premature ventricular contraction (PVC) candidates or atrial premature contraction (APC) candidates based on whether a difference between the pair of consecutive heartbeat intervals is larger than a product of a factor and the average of heartbeat intervals and whether an average of the pair of consecutive heartbeat intervals is within a predetermined range.

Abstract: A method to determine presence of a disease condition in a medical patient by evaluating conductivity information. Point-attributes values obtained from highly accurate conductivity data-sets taken as a function of time, over a period of time, are compared to previously determined threshold values. Z-scores may be determined to combine a plurality of point-attribute values in formulation of a composite score for a patient. Sometimes, z-scores are weighted by overall accuracy of the point-attribute in predicting presence of the disease.

Abstract: An MRI image processing and analysis system may identify instances of structure in MRI flow data, e.g., coherency, derive contours and/or clinical markers based on the identified structures. The system may be remotely located from one or more MRI acquisition systems, and perform: perform error detection and/or correction on MRI data sets (e.g., phase error correction, phase aliasing, signal unwrapping, and/or on other artifacts); segmentation; visualization of flow (e.g., velocity, arterial versus venous flow, shunts) superimposed on anatomical structure, quantification; verification; and/or generation of patient specific 4-D flow protocols. An asynchronous command and imaging pipeline allows remote image processing and analysis in a timely and secure manner even with complicated or large 4-D flow MRI data sets.

Abstract: There is disclosed a respiration rate monitoring system and method using a non-invasive device and method of monitoring it nearly continuously. One aspect includes receiving a series of signal data points from an optical sensor, detecting a series of peaks or valleys for the filtered signal data points, determining the time difference between individual peaks or valleys of the series of peaks or valleys to produce a series of time difference values, detecting peaks or valleys for the series of time difference values, determining widths between the peaks or valleys of the series of time difference values, and estimating a respiration rate from the widths between the peaks or valleys of the series of time difference values, and converting the estimation of a respiration rate to an indicator indicative of a respiration rate.

Abstract: A subject interface appliance (10) configured to deliver a breathable substance to a subject. The subject interface appliance includes a primary interface (12) configured to deliver a breathable substance to the subject, and a secondary interface (14) configured to obtain gas samples from the airway of the subject. The secondary interface is resiliently held at a default position with respect to the primary interface. The default position is located such that installation of the primary and secondary interfaces on the subject results in the application of a bias force to the secondary interface that holds the secondary interface in place.

Abstract: Pacer activity data of a user may be managed. For example, historical activity data of a user corresponding to a particular time of a day prior to a current day may be received. Additionally, a user interface configured to display an activity goal of the user may be generated and the user interface may be provided for presentation. In some aspects, the user interface may be configured to display a first indicator that identifies cumulative progress towards the activity goal and a second indicator that identifies predicted cumulative progress towards the activity goal. The cumulative progress may be calculated based on monitored activity from a start of the current day to the particular time of the current day and the predicted cumulative progress may be calculated based on the received historical activity data corresponding to the particular time of the day prior to the current day.

Abstract: A plurality of wireless vital sensors for capturing biometric data of individuals is laid out and fixed at predetermined setting locations. The vital sensors are configured to sense the biometric data of an individual via non-contact when the individual enters the sensing area of any one of the plurality of vital sensors. Moreover, there is no discomfort while the wireless vital sensor is attached or no risk of damage to or destruction of the wireless vital sensor due to collisions during games. Additionally, the measuring device also includes the identification sensors for identifying a mobile object, and the individual corresponding to the biometric data sensed by the vital sensors is identified by the RFID data from the identification sensor. Accordingly, in a configuration where the wireless vital sensors can capture the biometric data of an unspecified number of individuals, which individual the biometric data belongs to can be surely identified.

Abstract: A balance and/or gait perturbation system is disclosed herein. The balance and/or gait perturbation system includes a balance and/or gait perturbation device, at least one visual display device having an output screen, and one or more data processing devices. The one or more data processing devices are operatively coupled to the balance and/or gait perturbation device and the at least one visual display device, the one or more data processing devices are configured to generate a stochastic signal for controlling a display parameter of one or more scenes on the output screen of the at least one visual display device, and the one or more data processing devices are further configured to display the one or more scenes on the output screen of the at least one visual display device using the stochastic signal such that the one or more scenes perturb a balance and/or gait of the person.

Abstract: Low-cost, easy-to-use alignment target generators for aligning a user's own face or eye to a camera or scanner are based on field-of-view visual feedback from a filtered or apertured planar light source. These approaches may be made agnostic to the scanner's operating system or other software. Alternatively, software on the scanner or its host device may create a solid light-colored section of an existing display screen to use as a planar light source. In some embodiments, the planar light source may be the virtual image of an object viewed in a plane mirror.

Abstract: A method of providing audiometric feedback from a network of distributed body sensors using one or more earpieces includes receiving signals from the network of distributed body sensors at the one or more wireless earpieces, processing the signals received at the one or more wireless earpieces to determine a location of individual body sensors within the network of distributed body sensors relative the one or more earpieces, and producing audiometric feedback at the one or more wireless earpieces at least partially based on the locations of the individual body sensors relative to the one or more earpieces.

Abstract: Method, system and apparatus for patient communications in remote hearing diagnostics is disclosed. The invention may include electrical circuitry for conditioning audio input and output signals as well as a means of switching paths for the audio data between equipment sources and personnel involved in a remote hearing diagnostics session.

Abstract: Embodiments of the present disclosure include detecting a concurrent occurrence of a decrease in monitored analyte level and a corresponding decrease in monitored on-skin temperature, confirming a presence of an impending hypoglycemic condition, and asserting a notification corresponding to the confirmed impending hypoglycemic condition. Devices, methods, systems and kits incorporating the same are also provided.

Abstract: Described is a hand-held measuring device 1 for measuring the pH value of wounds at a measuring point, wherein the hand-held measuring device 1 comprises a housing 2, a removable protective case 5 which at least partially encloses the housing 2, and a detection and evaluation unit constructed of at least two elements 6, 7, 9. The evaluation unit is designed to process the measured signals detected by the detection unit. At least one element 7 of the detection and evaluation unit is arranged in or on the housing 2 and at least one element 6, 9 of the detection and evaluation unit is designed as a component of the protective case 5.

Abstract: A device for mounting an electrochemical sensor unit to a skin surface of a human being comprises a mounting member having a circumferential wall, an adhesive tape at a lower end of the circumferential wall for adhering the mounting member to the skin surface, and a sealing member. The sealing member provides a liquid tight seal between a lumen or measuring chamber defined between the skin surface, the mounting device and the sensor unit, the measuring chamber being normally filled with a contact liquid. Alternatively, the sealing member is provided on the sensor unit. The provision of the sealing member renders the system less vulnerable to force impacts and reduces the risk of flawed measurements due to atmospheric air in the measuring chamber. The electrochemical sensor unit may e.g. be suitable for transcutaneous measurement of partial carbon dioxide pressure (pCO2) or partial oxygen pressure (pO2).

Abstract: A method and system for distributing contacting information between applications is provided. The system preferably uses an ENUM-type protocol and a middleware tool kit to associate telephone numbers to other identifying information, such as e-mail addresses or URLs for web sites. The system enables the associated contacting information to be shared across multiple applications that may be implemented on a computer or a mobile telephony device. Information is shared only after verification that a requester is authorized to receive the requested contacting information.

Abstract: According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; c) calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and d) using the calibrated sensor to determine the blood oxygen parameter value within the subject's tissue.

Abstract: A biological signal measuring system includes: a light emitter emitting a first light beam and a second light beam; a light receiver outputting first and second signals in accordance with light intensities of the first and second light beams that have been passed through or reflected from a living tissue of a subject; a first calculating section acquiring a light attenuation of the first light beam based on the first signal and a light attenuation of the second light beam based on the second signal; a second calculating section acquiring a blood-derived light attenuation based on the light attenuation of the first and second light beams; a third calculating section acquiring information relating to a blood oxygen saturation based on a change amount of the blood-derived light attenuation associated with pressurization of the living tissue; and an outputting section outputting the acquired information.

Abstract: A detecting device for detecting physiological parameters of a biological tissue includes a light source, at least one light detector, a package, an outer cover, and an optical microstructure. The light source is configured to emit a first beam and a second beam. The package is disposed on the light source and the light detector and is located on the transmission paths of the first and second beams. The outer cover covers the light source, the light detector and the package, and includes a top surface. The optical microstructure is located in the transmission paths of the first and second beams, and is arranged in parallel with the top surface of the outer cover. The optical microstructure includes at least one set of circles of different radii, and is made of a diffractive optical element, a holographic optical element, a computer-generated holographic element, a fresnel lens or a lens grating.

Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Abstract: Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed.

Abstract: A disposable test cartridge and method for a point-of-care analyzer includes a cartridge body having a plurality of chambers where each of the plurality of chambers has an opening at a top of the cartridge body, a cartridge cover connected to the cartridge body where the cartridge cover has a capillary-receiving aperture, a capillary wiper disposed within the capillary-receiving aperture where the capillary-receiving aperture is aligned with one of the plurality of chambers of the cartridge body, and a capillary element removably insertable into the cartridge cover where the capillary element has a capillary tube that extends into the capillary-receiving aperture and through the capillary wiper where a tip portion of the capillary tube extends into the cartridge body.

Abstract: The present invention relates to a safety support system (10), comprising a data interface (20) for receiving sleep quality data carrying information on the sleep quality of a person (12), a sleep quality assessment unit (22) for determining a sleep quality indicator being indicative of the sleep quality of the person (12) based on the received sleep quality data and a safety unit (24) for determining machine operation settings for the person (12) based on the sleep quality indicator, said machine operation settings being indicative of an allowed operation of a machine (14) by the person (12). The present invention further relates to a corresponding method and to a machine (14) comprising a safety support system (10) as described above.

Abstract: The present invention relates to systems and methods for early detection, assessment, monitoring and prevention of pathophysiological conditions originating and/or emanating from skin or localized tissues, including but not limited to acute or chronic episodes of soft tissue pathology, wound, injury, dermatological or rheumatoid condition where bio-signal patterns, biomarkers or other identifiable elements or references would deviate from baseline. Specifically, the present invention relates to methods and systems specially designed and adapted for early detection of a latent pathogenic bio-signal anomaly using multiple aggregated sensors before the anomaly would otherwise be detectable.

Abstract: A two layer compression garment measuring system that displays a pressure indicia when the garment is stretched, wherein the pressure indicia is displayed by moving from a position under an opaque layer of material (at low or no pressure) to a position under a window or transparent or translucent layer of material (at higher pressure). When the indicia can be seen by an observer through the window or transparent or translucent layer, then the higher pressure has been reached. The viewed indicia optionally displays the pressure level. In various optional designs, the location of attachment between the two spaced-apart locations is adjustable, or the length of the upper layer is adjustable such that the attachment location can be aligned with the indicia. A design having a free ended upper layer is also included.

Abstract: An optical sensor includes: a light emitter; a light receiver; a rod-shaped grasping member in which one of the light emitter and the light receiver is disposed, and which is to be grasped by a hand of a subject; and a clamping member which is adapted to clamp a part of the hand of the subject with the grasping member, another one of the light emitter and the light receiver being disposed in the clamping member.

Abstract: A sensor guide wire for an intravascular measurement of a physiological variable in a living body may include a sensor element configured to measure the physiological variable based on exposure to fluid in the living body; and a cylindrical-shaped jacket forming an interior space housing the sensor element. The jacket comprises an outer circumferential wall with a circumferential surface extending between distal and proximal longitudinal ends of the jacket. The outer circumferential wall of the jacket does not include any apertures along its circumferential surface so as to prevent fluid from passing through the outer circumferential wall and/or the jacket has a constant cross section along its entire length.

Abstract: An implantable device includes a body part and a piezoelectric part. The body part is configured to grasp a pulsatile organic or inorganic tissue. The piezoelectric part is mechanically coupled to the body part and is configured to convert a varying shear force transferred from the body part to the piezoelectric part into voltage. An implantable system, comprises the implantable device and a stent like object configured to be inserted and deployed within a pulsatile or static tissue. The implantable device is configured to form a sealed junction with the pulsatile tissue while pressing against an outer circumference area of the stent.

Abstract: A biometric authentication device collates pre-registered biometric data for authentication with biometric data acquired during authentication. An imaging section images biometric data acquired by penetration through the finger by near-infrared light from a near-infrared light irradiating section. A control section acquires the biometric data acquired by the imaging section. A visible light irradiating section irradiates a finger inserting section where the finger is inserted with visible light. The visible light irradiating section starts irradiation of the visible light before the imaging section acquires the biometric data.

Abstract: An apparatus for performing electrical impedance detection and ultrasound scanning of body tissue, the apparatus including: an electrode array for performing electrical impedance detection by applying a first electrical signal to the body tissue, receiving an electrical response signal characteristic of the body tissue, and providing a first output signal representative of the electrical response signal; and an ultrasound transducer for performing ultrasound scanning by applying a first ultrasound signal to the body tissue, receiving an ultrasound response signal characteristic of the body tissue, and providing a second output signal representative of the ultrasound response signal, wherein the ultrasound transducer is mounted so as to be moveable during performance of the ultrasound scanning.

Abstract: The present invention, in one form, is a method for deriving respiratory gated PET image reconstruction from raw PET data. In reconstructing the respiratory gated images in accordance with the present invention, respiratory motion information derived from individual voxel signal fluctuations, is used in combination to create usable respiratory phase information. Employing this method allows the respiratory gated PET images to be reconstructed from PET data with out the use of external hardware, and in a fully automated manner.

Abstract: Some embodiments are associated with an input signal comprising a first and a second photon event incident on a photon-counting semiconductor detector. A relatively slow charge collection shaping amplifier may receive the input signal and output an indication of a total amount of energy associated with the superposition of the first and second events. A relatively fast charge collection shaping amplifier may receive the input signal and output an indication that is used to allocate a first portion of the total amount of energy to the first event and a second portion of the total amount of energy to the second event.