Abstract: A wrist computer to be worn on an arm of a user, comprising a detection device configured to detect at least one vital parameter of the user, and a radio module configured to, when activated, establish and maintain a wireless data connection to a radio module of another object, wherein the wrist computer comprises a control unit configured to activate the radio module of the wrist computer when the at least one vital parameter of the user is detected by the detection device, and to deactivate the radio module of the wrist computer when the at least one vital parameter of the user is no longer detected by the detection device.

Abstract: An assistive sample collection and storage assembly for collecting, transferring and storing a biological sample includes a sample collection device having a first portion and a second portion. The first portion is configured to receive a sample collection member. The assembly includes a sample storage device comprising a sample substrate configured to receive at least a portion of the biological sample from the sample collection member. The assembly is configured to exist in a first state and a second state. The sample collection member is disposed at a determined distance from the sample substrate in the first state. At least a portion of the sample collection member is in physical contact with at least a portion of the sample substrate in the second state. The sample collection member is configured to apply a determined amount of contact force between the collection member and the sample substrate in the second state of the assembly.

Abstract: A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment provides a system adapted to provide co-registered autofluorescence-optical coherence tomography (AF-OCT) imaging. AF excitation light is introduced and collected AF light is extracted at a fiber optic rotary joint (FORJ) equipped with an embedded dichroic mirror. A probe tip that uses a clad fiber to supply light to a focusing element provides enhanced OCT and AF performance.

Abstract: Apparatus and methods are disclosed for multi-spectral imaging of tissue to obtain information about the distribution of fluorophores and chromophores in the tissue. Using specific spectral bands for illumination and specific spectral bands for detection, the signal-to-noise ratio and information related to the distribution of specific fluorophores is enhanced as compared to UV photography, which uses a single RGB image. Furthermore, the chromophore distribution information derived from the multi-spectral absorption images can be used to correct the fluorescence measurements. The combined fluorescence, absorption, and broadband reflectance data can be analyzed for disease diagnosis and skin feature detection.

Abstract: Described herein are systems and methods for detecting a physiological response based on thermal measurements while accounting for consumption of a confounding substance such as a medication, alcohol, caffeine, or nicotine. In one embodiment, a system includes a computer and an inward-facing head-mounted thermal camera (CAM) that takes thermal measurements of a region of interest (THROI) on a user's face. The computer receives an indication indicative of the user consuming a confounding substance that affects THROI, and detects the physiological response while the consumed confounding substance affects THROI. The detection is based on THROI, the indication and a model. Optionally, the model was trained on: a first set of THROI taken while the confounding substance affected THROI, and a second set of THROI taken while the confounding substance did not affect THROI.

Abstract: A camera head of a dental camera for detecting caries in an interdental space has an illuminating device for illuminating a tooth adjacent to the interdental space, which includes an infrared light source. The camera head further includes optics which have an image plane and an object plane, wherein an image sensor is located in the image plane, and the object plane divides the space into two half spaces, wherein a first half space contains the optics and is located in front of the object plane, and a second half space is located behind the object plane, both as seen from the optics. The illuminating device and the optics are designed and arranged with respect to one another in such a way that the illuminating device is arranged in the first half space and infrared light exiting the illuminating device is aimed in the direction of the second half space.

Abstract: A photoacoustic measuring apparatus includes a light source, a movable holding unit which holds an object, a light diffusing unit which fixes the distance between the light diffusing unit and the holding unit and diffuses light incident from the light source, and an acoustic wave obtaining unit which obtains an acoustic wave generated from the object by the light emitted via the holding unit and the light diffusing unit.

Abstract: A polysiloxane elastomer containing liquid crystal lateral chain, and a smart watch made therefrom are disclosed. The polysiloxane elastomer containing liquid crystal lateral chain includes a polysiloxane backbone chain and a lateral chain formed by a liquid crystalline monomer and connected with the polysiloxane backbone chain, wherein the polysiloxane backbone chain is crosslinked by a crosslinking agent.

Abstract: Apparatus and method for managing animals such as but not limited to livestock. In some embodiments, an ear tag assembly has a main body, a backing member and a shaft that extends through an aperture through an outer ear of an animal to interconnect the main body and the backing member. A primary temperature sensor obtains an outer ear temperature of the outer ear. An ambient temperature sensor obtains an ambient temperature of a surrounding environment external to the animal. A control circuit receives the outer ear and ambient temperatures and determines a state of the animal responsive to a comparison of the outer ear temperature and the ambient temperature over a selected time interval.

Abstract: A method and system for prediction of post-stenting hemodynamic metrics for treatment planning of arterial stenosis is disclosed. A pre-stenting patient-specific anatomical model of the coronary arteries is extracted from medical image data of a patient Blood flow is simulated in the pre-stenting patient-specific anatomical model of the coronary arteries with a modified pressure-drop model that simulates an effect of stenting on a target stenosis region used to compute a pressure drop over the target stenosis region. Parameter values for the modified pressure-drop model are set without modifying the pre-stenting patient-specific anatomical model of the coronary arteries. A predicted post-stenting hemodynamic metric for the target stenosis region, such as fractional flow reserve (FFR), is calculated based on the pressure-drop over the target stenosis region computed using the modified pressure-drop model.

Abstract: A medical device system and method that includes sensing a heart sound signal from a first external sensor, determining whether a pulmonary hypertension signature is detected in response to the sensed heart sound signal, sensing a lung sound signal from a second external sensor, determining whether a heart failure signature is detected in response to the sensed lung sound signal, and determining therapy parameters in response to determining whether a pulmonary hypertension signature is detected and determining whether a heart failure signature is detected.

Abstract: Systems for monitoring left atrial pressure using implantable cardiac monitoring devices and, more specifically, to a left atrial pressure sensor implanted through a septal wall are presented herein.

Abstract: A catheter is disclosed for providing a pressure measurement at a vascular lesion. The catheter includes a tubular component having dual lumens along at least a segment thereof in which a first lumen acts as a pressure inlet and a second lumen allows the catheter to be tracked over a guidewire. A plurality of openings are located along a distal segment of the tubular component that permit blood flow into the first lumen when disposed in vivo. A pressure sensor is located within a handle component of the catheter or within the tubular component to be in fluid communication with a proximal end of the first lumen. When the catheter is positioned at the vascular lesion, the first lumen fills with blood via the plurality of openings such that the pressure sensor is able to sense a pressure of the blood at a distal end of the catheter.

Abstract: An electronic blood pressure monitor retrieves a pulsewave signal that is superimposed on a cuff pressure signal and indicates a pulsewave at a measurement site, and acquires a string of pulsewave amplitudes indicated by the pulsewave signal. A first envelope connects the amplitudes created for the acquired string of pulsewave amplitudes. Local maxima and minima in the first envelope are detected. With respect to the strings of amplitudes corresponding respectively to the local maxima and minima, a local-maximum envelope and a local-minimum envelope connecting the amplitudes are created. Two pressure values at points at which portions on the high-pressure-side and low-pressure-side with respect to the maximum peaks of the local-maximum envelope and the local-minimum envelope respectively cross first and second threshold levels are obtained, and the average values of each pair of pressure values are calculated as the systolic blood pressure and the diastolic blood pressure respectively.

Abstract: Traditional electrocardiography (ECG) and photo-plethysmography (PPG) based HR estimation require human skin contact which is not only user uncomfortable, but also infeasible when multiple user monitoring is required or extreme sensitive conditions is a prime concern as in the case of monitoring neonates, sleeping human and skin damaged patients. Temporal signals depicting the motion or color variations in the frames across time, are estimated from a Region of Interest using Eulerian or Lagrangian approaches. However, the Eulerian approach fails under improper illumination, inappropriate camera focus or human factors like skin color. Likewise, Lagrangian approach is highly time-consuming and may fail when few or less discriminatory features are available for tracking. The present disclosure provides a poorness measure that is indicative of when an approach fails and facilitates serial fusion of the two approaches. Switching to an appropriate approach results in accurate heart rate estimation.

Abstract: A software app for a mobile device is disclosed for alerting a custodian of a person to be protected of an emergency situation involving the person to be protected. The app includes software instructions for carrying out a method including: establishing a range of normal heart rates for the person using a heart rate monitor; detecting a heart rate for the person that is outside of the established range; activating at least one of a camera, a microphone, an accelerometer, and a location indicator on the mobile device carried by the person; establishing a wireless data connection between the mobile device and a communication network; and transmitting data to the custodian from the activated camera, microphone, accelerometer, or location indicator via the communication network. The app can notify a custodian of a medical or safety emergency as it is happening, giving that custodian the ability to immediately notify emergency personnel.

Abstract: Aspects of the present disclosure are directed to a CPU and a memory circuit that has user-corresponding data stored on the memory circuit, and a platform over which a plurality of electrodes are interleaved, and configured for engaging the user. While the plurality of electrodes is concurrently contacting a limb or other extremity of the user, measurement signals are obtained from the plurality of electrodes. Based on a plurality of impedance-measurement signals being obtained from the electrodes, signals are generated that correspond to cardiovascular timings specific to the user. In such aspects of the present disclosure, pulse characteristic signals are determined based on the plurality of impedance-measurement signals and comparisons of user-obtained data are made relative to user-data profiles stored in the memory circuit.

Abstract: An implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested. The device comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrate. Not only the substrate, but also the leads are stretchable. The substrate may consist of PDMS, and the leads may consist of a conductive PDMS, in particular, PDMS with an electrically conductive filler material, and may optionally be metal-coated. The device defines a multi-electrode array which may be employed for neurostimulation in the epidural or subdural space of an animal or human.

Abstract: A method for autonomic nervous system sensitivity-point testing on a skin of a patient is described. The method includes generating an electrotherapy signal that stimulates a vagal response of an autonomic nervous system of the patient when the patient is tested. The method further includes providing an electrically conductive tip that electrically contacts but does not puncture the skin when the patient is tested and coupling the electrotherapy signal to the electrically conductive tip.

Abstract: An apparatus comprising a plurality of electrically conductive elements for transmitting an electrical signal from a sensor to a medical device is described, wherein the electrically conductive elements are moveable between a first stored position and a second in use position. In this manner the apparatus provides an interface between the sensor and the medical device such that the length of each of the electrically conductive elements can be varied and adjusted such that the excess amount of the elements is minimized and the functionality of the sensors and/or medical device maximized.

Abstract: This invention is a device to monitor caloric intake comprising: a wearable member that is worn in a manner similar to eyeglasses; and an EEG sensor, wherein indications that a person is probably eating are based on electromagnetic waves from the person's brain. In an example, this device can further comprise one or more automatic-imaging members that automatically take pictures when the person eats based on data from the EEG sensor.

Abstract: A device for performing EEG which consists of an elastic head strap, electrodes, and a wireless transmitter. The wireless transmitter, which displays indicators of electrode impedance, is secured to a patient using a docking station attached to the head strap at the crown of a subject's head and is placed into electrical communication with the electrodes using conductive thread sewn into the head strap. A simplified user interface comprising graphical elements improves the detection of brain wave patterns.

Abstract: A portable apparatus and a method of changing a content screen of the portable apparatus are provided. The portable apparatus includes changing a displayed content in response to an increase in a visual fatigue and a method of changing a content screen of the portable apparatus. Some of disclosed various embodiments provide a portable apparatus that calculates a visual fatigue by using user electroencephalogram (EEG) information received from a wearable apparatus and changing a displayed content into another content in response to an increase in the calculated visual fatigue, and a method of changing a content screen of the portable apparatus.

Abstract: A system including a detector array configured to receive electromagnetic (EM) radiation from a target object, the detector array having one or more detectors is disclosed. The system also includes a readout integrated circuit and one or more processors. The readout integrated circuit has a circuit comprising a number of detector boundary selection components, each one of the number of detector boundary selection components configured to select or adjust a detector boundary from least one of a sub-column boundary or an adjustable boundary.

Abstract: The device is used to measure bioimpedances and has in each case at least one measurement electrode for each foot and each hand of a person who is to be measured. The electrodes are connected to an evaluation unit. In addition, at least one balance is used to determine a body weight of the person who is to be measured. The hand electrodes, provided for contact with the hands of the person who is to be measured, are arranged in the area of at least one positionable support element.

Abstract: Verification that an implantable medical system within a patient is MRI safe is provided. Several verifications may be performed such as verifying that the device and leads are of an MRI safe type, that the leads have adequate electrical integrity, that the device has entered an MRI safe mode, that the lead routing and device placement are MRI safe, and that the MRI settings of the MRI machine are safe for the implantable medical system. The result of these verifications may lead to a conclusion that the implantable medical system of interest is or is not MRI safe for a given MRI scan. An indication of this result may be output such as via a display so that an MRI technician can have some assurance as to whether to conduct the MRI scan.

Abstract: The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device.

Abstract: A device for measuring a component in exhaled breath comprising an inlet (32) for receiving exhaled breath, a buffer chamber (31). A first fluid conduit (34a) is in fluid connection with the inlet and adapted to lead a first portion (?) of the exhaled breath to the buffer chamber. The buffer chamber comprises an outlet (37) for discarding a first part of exhaled breath received from the first fluid conduit and the buffer chamber is configured to buffer a second part of exhaled breath received from the first fluid conduit. The device comprises a second fluid conduit (34b) in fluid connection with the inlet and adapted to lead a second portion (I?) of the exhaled breath to be discarded, and a sensor (63) for measuring a component in the exhaled breath buffered in the buffer chamber.

Abstract: An apparatus for tracking patients utilizes a wristband with integrated radio frequency circuits (RFIC). The wristband may further incorporate an antenna on a flex PCB. The wristband may also be disposable and comprising means for replacing the RFIC.

Abstract: A pressure-sensing device is disclosed, which includes a pressure sensor pad. The pressure sensor pad includes a first planar substrate, a second planar substrate, first signal lines, second signal lines, a plurality of rows of first sensor components, and a plurality of columns of second sensor components. The first signal lines and the rows of first sensor components are formed on the first planar substrate, and each row of the first sensor components is connected to a corresponding one of the first signal lines. The second planar substrate is disposed opposite to the first planar substrate. The second signal lines and the columns of second sensor components are formed on the second planar substrate, and each column of the second sensor components is connected to a corresponding one of the second signal lines, where the second sensor components face the first sensor components respectively.

Abstract: Techniques are described for improving results of hearing tests. For example, the hearing tests described herein may be divided into multiple hearing test segments which may be provided to the test subject individually. Additionally, the hearing test may include multiple cognitive test segments that may be interleaved between the hearing test segments to gauge the test subject's awareness level.

Abstract: Disclosed herein are sensors with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.

Abstract: According to some embodiments of the present invention, a display is used to show an indication of the signal's quality. This indication of the signal's quality may be provided in a number of ways, including audibly or visually.

Abstract: This disclosure relates to a nanoporous composition including a number of clusters of nanoparticles dispersed in a liquid, a nanoporous layer formed of the nanoporous composition, a glucose-oxidation electrode including the nanoporous layer, and a glucose-sensing device and system including the glucose-oxidation electrode. This disclosure also relates to a method of making the nanoporous composition, the nanoporous layer, the glucose-oxidation electrode and the glucose-sensing device and system. Further, this disclosure also relates to devices, systems and methods for continuous glucose monitoring (CGM) and blood glucose monitoring (BGM).

Abstract: The present invention relates to a method and system for estimating blood analyte levels using a noninvasive optical coherence tomography (OCT) based physiological monitor. An algorithm correlates OCT-based estimated blood analyte data with actual blood analyte data determined by other methods, such as invasively. OCT-based data is fit to the obtained blood analyte measurements to achieve the best correlation. Once the algorithm has generated sets of estimated blood analyte levels, it may refine the number of sets by applying one or more mathematical filters. The OCT-based physiological monitor can be calibrated using an Intensity Difference plot or the Pearson Product Moment Correlation method.

Abstract: Disclosed is a method and system for analyzing stress and managing stress by using a mobile electronic apparatus and a data management server. The method includes: generating bio-signal pattern information upon periodically receiving a bio-signal from a bio-signal measuring device connected to each of a plurality of unspecified individuals, and forming reference information for stress analysis based on received answers to each of a plurality of questions for checking a stress level; receiving bio-signal pattern information from a bio-signal measuring device connected to a specified user; and determining a stress level corresponding to the bio-signal pattern information of the specified user based on the reference information.

Abstract: An apparatus for measuring at least one measure related to urination of an individual such as urine flow rate and/or urine quantity. The apparatus is configured to produce acoustic and/or electromagnetic signals indicative of the at least one urination measure upon having urine applied thereover. The invention also provides systems and methods that detect the acoustic and/or electromagnetic signals originating from the apparatus being used by the individual and analyze the detected signals to calculate the at least one measure therefrom by using a designated application module operable via an end device using acoustic sensing means or data receiving means of the end device for detecting the acoustic and/or electromagnetic signals.

Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.

Abstract: This invention relates to methods for ascertaining at least one of liver fibrosis or cirrhosis in a subject, by processing of one or more medical images of the liver, using a computing machine, to quantify nodularity of the surface of the liver and calculate a liver surface nodularity score.

Abstract: An apparatus for noninvasively measuring a bio-analyte including a metering device configured to obtain at least one of light and electrical information representative of an amount of fibrous protein from skin of a subject; and a processor configured to determine information representative of an amount an analyte present in blood of the subject based on the obtained information representative of an amount of the fibrous protein.

Abstract: The present invention relates to methods for an objective and quantitative erythema documentation and analysis. In particular, the invention relates to a method for assessing erythema of a subject comprising the steps of measuring the light reflectance of a skin or mucosal area of the subject, obtaining the L* value and the a* value of said measurement according to the L*a*b* color space, and calculating the erythema value according to the formula (L*max?L*)×a*.

Abstract: A muscle activity and skeletal monitoring system and method are disclosed. A network of at least two distributed inertial sensor nodes are configured to communicate with each other over a first interface. Each of the inertial sensor nodes comprises at least one sensor configured to sense muscle vibrations and monitor body motion. A muscle activity recognition and motion tracking and visualization methods also are disclosed.

Abstract: Thermal measurements of the forehead can be indicative of brain activity, and as such, may be useful for conducting brain-related treatments, such as neurofeedback. In one embodiment, a system for conducting a neurofeedback session includes an inward-facing head-mounted thermal camera (CAM) and a user interface. CAM takes thermal measurements of a region on the forehead (THF) of a user, and is located below the middle of the region. The user interface provides, based on THF, the neurofeedback session for the user. Optionally, a computer controls the neurofeedback session by providing the user feedback via the user interface. The computer may generate the feedback based on the similarity between a current THF pattern and a previous THF pattern of the user taken while the user was in a target state.

Abstract: An apparatus for estimating an anaerobic threshold may include a heart rate detector configured to detect a heart rate from a signal sensed from a user, and an anaerobic threshold estimator configured to estimate an anaerobic threshold of the user based on a change in the detected heart rate.

Abstract: Devices and methods are described for a hand-held hydration monitor including a viewfinder including one or more alignment features configured to align with a target on a subject; a micro-impulse radar component; a data storage component including stored information associated with reference reflected pulses correlated with reference hydration states; a user interface; and a computing component including a processor and circuitry, the circuitry including micro-impulse radar control circuitry configured to actuated the micro-impulse radar component, and hydration determination circuitry configured to receive information associated with one or more reflected pulses from a tissue associated with the target on the subject and to compare the information associated with the one or more reflected pulses from the tissue associated with the target on the subject with the stored information associated with the reference reflected pulses correlated with the reference hydration states to determine a relative hydration st

Abstract: A method includes forming one or more vias in a substrate, forming at least one liner on at least one sidewall of at least one of the vias, and filling said at least one via with solder material using injection molded soldering. The at least one liner may comprise a solder adhesion layer, a barrier layer, or a combination of a barrier layer and a solder adhesion layer.

Abstract: Embodiments include method, systems and computer program products for automatic adjustment of helmet parameters based on a category of play. Aspects include monitoring a plurality of sensors in a helmet and determining the category of play for a user of the helmet based on data received from the plurality of sensors. Aspects further include automatically adjusting one or more parameters of the helmet based on the category of play.

Abstract: A system for control of a device includes at least one sensor module detecting orientation of a user's body part. The at least one sensor module is in communication with a device module configured to command an associated device. The at least one sensor module detects orientation of the body part. The at least one sensor module sends output signals related to orientation of the user's body part to the device module and the device module controls the associated device based on the signals from the at least one sensor module.

Abstract: A testing device which provides testing relating to a health parameter monitoring device and/or a health monitoring application run at a user device is disclosed. In one embodiment, the device comprises: a transceiver which receives a control signal from a controlling device; a health parameter monitoring device connection port which connects to the health parameter monitoring device; a user device connection port which connects to the user device; and a plurality of simulation apparatus configured to electronically recreate one or more physiological parameters of a user according to the control signal. The physiological parameters are monitored by the health parameter monitoring device, which provides a plurality of data relating thereto to the user device for entry within the health monitoring application. The user device outputs at least a display of the health monitoring application to the controlling device for analysis thereof. Systems and methods for performing testing are also provided.

Abstract: An apparatus, system, and method directed to detecting a physiological signal during discrete time separated detection windows, deriving one or more respiratory disturbance indices from the physiological signal, detecting a respiratory disturbance state in response to the one or more respiratory disturbance indices deviating from a threshold value, interpolating the one or more respiratory disturbance indices between adjacent time separated detection windows, and declaring a respiratory disturbance episode based on the detected respiratory disturbance state during the detection windows and the interpolation between detection windows.