Abstract: A fundus imaging apparatus according to embodiments of the present invention includes an optical unit configured to guide light from a fiber light source to a fundus of a subject eye, a wavefront sensor capable of measuring the wavefront of reflected light guided via the optical unit after the light from the fiber light source is reflected on the fundus, a wavefront correction device provided on an optical path extending between the fiber light source and the subject eye to correct the wavefront of the reflected light, an APD that can receive the reflected light and capture an image of the fundus, and a processing and control unit configured to acquire thickness information about an optical diffusive layer of the fundus and determine a correction value to be used when the wavefront correction device corrects the wavefront of the reflected light based on the acquired thickness information.

Abstract: From OCT-measured data, only the image data of the choroidal vascular network present in the layer of the choroidal layer is selectively extracted, thereby accurately obtaining the thickness of the choroidal vessels and thickness of the choroidal vascular network from the image data, to allow for quantitative evaluation of the choroidal vascular network. The optical coherence tomography apparatus has an optical coherence tomography device, and a computer that processes the three-dimensional OCT tomographic images obtained based on the OCT-measured data acquired by the optical coherence tomography device. The computer functions as a means for selectively separating out only the images of the choroidal vessels from the three-dimensional OCT tomographic images to acquire image data of the choroidal vessels, and also as a means for obtaining the data to be used in the quantitative evaluation of the shape of the choroidal vessels based on the image data of the choroidal vessels.

Abstract: An information display and control system that enables a fast and easy understanding and management of the status of the patient's cardiovascular and ventilation systems is disclosed. The system can control administration and management of a patient's medication and fluids. The display is organized by goals related to management of patient's cardiovascular system, ventilation system, and medications and fluids administration and management. Such goals include hemodynamics, oxygenation, CO2 removal, medication status, and fluids status.

Abstract: A navigation system for use in a luminal network of a patient, such as the airways, that is able to analyze a three-dimensional model of the luminal network and automatically determine a pathway from an entry point to a designated target. The system further automatically assigns waypoints along the determined pathway in order to assist a physician in navigating a probe to the designated target.

Abstract: A remote patient monitoring system having a main patient monitor and a remote patient monitor. The main patient monitor is configured to receive and collect one or more patient physiological parameters and to provide an alarm in response to an alarm trigger. The alarm trigger includes a determination that at least one of the collected patient physiological parameters has reached a predetermined value. The remote patient monitor has an alarm reset and is configured to be carried by a caregiver. It is also configured to receive a signal from the main patient monitor in response to the alarm and to transmit an indication about the alarm trigger. The indication includes one or more of a notification that the patient is being attended to, a request by the caregiver for additional help, or a message about resolution of the alarm trigger.

Abstract: Methods and devices to monitor an analyte in body fluid are provided. Embodiments include continuous or discrete acquisition of analyte related data from a transcutaneously positioned in vivo analyte sensor automatically or upon request from a user.

Abstract: A method for establishing a connection between a first electronic computing device and a second electronic computing device includes moving the second electronic computing device so that it is proximal to the first electronic computing device. When the first electronic computing device detects the proximity of the first electronic computing device relative to the second electronic computing device, a radio on the first electronic device is set to a connectable and discoverable state. A wireless connection is automatically established between the first electronic computing device and the second electronic computing device. Data is transmitted between the first electronic computing device and the second electronic computing device.

Abstract: A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed comprising determining a rigid body transform that transforms a high resolution preoperative magnetic resonance image, MRIo, of the target site to a preoperative magnetic resonance image, iMRIo, of the target site acquired by an interoperative iMRI scanner, and a non-rigid body transform that transforms the iMRIo image to an image iMRI1 image of the site acquired by the interoperative iMRI scanner during the medical procedure, and using the rigid and non-rigid body transforms to transform the high resolution MRIo image.

Abstract: An imaging device includes laser diodes (LDs) generating near-infrared wavelength light, lenses configured to deliver the light to tissue, a first receiver having one or more detectors, and a first part with at least one of the LDs capable of being pulsed. The first receiver receives light reflected from the tissue and is synchronized to the pulsed light and configured to perform a time-of-flight measurement. An infrared camera receives light reflected by the tissue from a second part of the imaging device. The camera captures light while the second part is off, and while the second part is on to generate corresponding signals, and differences the signals to generate an image. An array of LDs generates a grid of spots on the tissue, which is reflected to the camera. A coupled phone, tablet, or computer receives and processes the time-of-flight measurement, the image, and the reflected grid of spots.

Abstract: A method for evaluating treatment outcome in a patient having a genetic predisposition for a malignant neoplasm before clinical manifestation of the neoplasm can be seen radiographically. The method permits visualization of any tumor, whether located externally on a patient's body or located internally in the body, and as small as 2 mm in diameter, using a biomarker. The method uses biomarkers conjugated with nanoparticles which include but are not limited to quantum dots, with the conjugated form collectively termed functionalized nanoparticles, that are heated under specified conditions to produce a photoacoustic signal that is then visualized to locate and/or treat the tumor.

Abstract: An image generating apparatus of the present invention has a determination unit that sets a target area in a part of an area inside a subject, executes processing to adjust a phase of each detection signal based on a distance from each detection element to a target area and a tentative velocity, and calculate dispersion of intensities of a plurality of detection signals of which phases are adjusted, for a plurality of tentative velocities, and determines a velocity for which dispersion of intensities is minimum, out of the plurality of tentative velocities, as a propagation velocity.

Abstract: Noninvasive methods and apparatus for detecting blood volume imbalances in a mammalian subject are disclosed. The method includes obtaining baseline measurements of at least three physiological parameters from a subject wherein the parameters are selected from the group consisting of heart rate, electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity. Measurements of electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity are taken at one or more extremities of the subject such as the calf, ankle, forearm, thigh, fingers and toes. The physiological parameters for which baseline measurements were obtained are then monitored to detect changes from the baseline measurements that indicate blood volume imbalances.

Abstract: A method is provided for determining blood pressure for a subject using a sphygmomanometer. The method includes: measuring an oscillometric cuff pressure waveform of the subject using the sphygmomanometer; representing the measured waveform with a physical model accounting for mechanics of the cuff, an artery and coupling between the cuff and the artery; determining the model unknowns from the measured waveform; and determining blood pressure for the subject using the determined model.

Abstract: Example apparatus and methods perform magnetic resonance fingerprinting (MRF) for arterial spin labeling (ASL) based parameter quantification. ASL with MRF produces a nuclear magnetic resonance signal time course from which simultaneous quantification of ASL perfusion-related parameters can be achieved. The parameters may include cerebral blood flow, transit time, T1, or other parameters. The quantification uses values from a dictionary of signal time courses that were generated or augmented using Bloch simulation, knowledge of the sequence, or previous observations. The dictionary may account for inflow or outflow of labeled spins and may model arterial input. An ASL-MRF pulse sequence may differ from conventional pulse sequences. For example, an ASL-MRF pulse sequence may include non-uniform control pulses, non-uniform label pulses, non-uniform post labeling delay time, non-uniform background suppression pulses, non-uniform acquisition repetition time, or non-uniform acquisition flip angle.

Abstract: Field effect devices, such as capacitors and field effect transistors, are used to interact with neurons. Cubic silicon carbide is biocompatible with the neuronal environment and has the chemical and physical resilience required to withstand the body environment and does not produce toxic byproducts. It is used as a basis for generating a biocompatible semiconductor field effect device that interacts with the brain for long periods of time. The device signals capacitively and receives signals using field effect transistors. These signals can be used to drive very complicated systems such as multiple degree of freedom limb prosthetics, sensory replacements, and may additionally assist in therapies for diseases like Parkinson's disease.

Abstract: A cardiac monitoring device includes: at least one sensing electrode for obtaining an electrocardiogram (ECG) signal from a patient; a processing unit comprising at least one processor operatively coupled to the at least one sensing electrode; and at least one non-transitory computer-readable medium comprising program instructions that, when executed by the at least one processor, causes the cardiac monitoring device to: obtain the ECG signal from the at least one sensing electrode; determine a transformed ECG signal based on the ECG signal; extract at least one value representing at least one feature of the transformed ECG signal; provide the at least one value to determine a score associated with the ECG signal, thereby providing an ECG-derived score; compare the ECG-derived score to a predetermined threshold score determined by machine learning; and provide an indication of a cardiac event if the ECG-derived score is one of above or below the predetermined threshold score determined by the machine learning

Abstract: The invention features a vital sign monitor that includes: 1) a hardware control component featuring a microprocessor that operates as interactive, icon-driven GUI on an LCD; and, 2) a sensor component that connects to the control component through a shielded coaxial cable. The sensor features: 1) an optical component that generates a first signal; 2) a plurality electrical components (e.g. electrodes) that generate a second signal; and, 3) an acoustic component that generates a third signal. The microprocessor runs compiled computer code that operates: 1) the touch panel LCD; 2) a graphical user interface that includes multiple icons corresponding to different software operations; 3) a file-management system for storing and retrieving vital sign information; and 4) USB and short-range wireless systems for transferring data to and from the device to a PC.

Abstract: Electroanatomic mapping is carried out by inserting a multi-electrode probe into a heart of a living subject, recording electrograms from the electrodes concurrently at respective locations in the heart, delimiting respective activation time intervals in the electrograms, generating a map of electrical propagation waves from the activation time intervals, maximizing coherence of the waves by adjusting local activation times within the activation time intervals of the electrograms, and reporting the adjusted local activation times.

Abstract: A method for determining electrophysiology properties of tissue comprising acquiring electrical signal data from a plurality of electrodes (130) of one or more catheters, determining at least one electrode clique from the plurality of adjacent electrodes (136), computing local conduction velocity vectors for the at least one electrode clique (138), determining at least one catheter orientation independent indicator from which to classify an arrhythmia source based on one or more of an angular dependence parameter associated with a flow field of the local velocity conduction vectors, an eccentricity parameter reflecting the uniformity of local conduction velocity, and divergence and curl-like sums or closed path integral parameters associated with the local velocity vectors, and displaying a rhythm classification responsive to catheter movement thereby facilitating identification of types and causes of arrhythmia disorders.

Abstract: A method of analyzing neurophysiological data recorded from a subject is disclosed. The method comprises identifying activity-related features in the data, and parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain. The method further comprises comparing at least some of the defined capsules to at least one reference capsule, and estimating a brain function of the subject based on the comparison.

Abstract: Devices that sense sweat and are capable of providing chronological assurance are described. The device uses at least one sensor to measure sweat or its components and to determine a sweat sampling rate. The chronological assurance is determined, at least in part, using the sweat sampling rate. The sweat sampling rate may be determined, at least in part, using a sweat volume and/or a sweat generation rate, both of which may be measured or predetermined.

Abstract: A system and method of suppressing stimulation artifacts when performing electrophysiological electrical stimulation and recording. An artifact waveform is captured associated with a stimulus output, and then the artifact waveform calibrated during another stimulus output for accurately representing the actual artifact waveform received within each measured response to a stimulus. During actual stimulus generation and response recording, the calibrated artifact waveform is subtracted in at least one of the amplifier stages so that the artifacts are removed from the amplified response to the stimulus thus providing an accurate output without saturating the amplifiers.

Abstract: A diagnostic apparatus comprising a sealed case, a first antenna and a second antenna and processing circuitry are disclosed herein. In some embodiments, the sealed case includes a biocompatible material and is configured for implantation within a body of a patient. Further, each one of the first antenna and the second antenna are configured to be implanted in the body in proximity to a target tissue, generate and transmit radio frequency (RF) electromagnetic waves through the target tissue to the other antenna, and output a signal in response to RF waves received from the other antenna. In addition, the processing circuitry can be contained within the case and is configured to receive and process the signal from each antenna so as to derive and output an indication of a characteristic of the target tissue.

Abstract: The present disclosure provides a neuronal resonance-magnetic resonance imaging (NR-MRI) method and technology for measuring a difference between a resting state and a state of providing external stimuli with respect to various frequency bands by using the NR-MRI scheme through frequency band selection filter characteristic mapping of neurons. In addition, the present disclosure provides technology for revealing a frequency selective communication mechanism between brain regions on the basis of systems biology researches for the frequency selective communication mechanism between the brain regions as well as technology useful for completing proof-of-concept and a frequency selective communication map between the entire brain regions.

Abstract: Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state.

Abstract: Apparatus, including a ferromagnetic sheet and at least one radiator, mounted in proximity to the ferromagnetic sheet and configured to radiate a magnetic field into a region in proximity thereto. The apparatus further includes a solid sheet of thermal insulation, mounted between the ferromagnetic sheet and the at least one radiator so as to prevent transfer of thermal energy from the at least one radiator to the ferromagnetic sheet.

Abstract: A device and a method for the analysis of the air exhaled by a subject in order to measure basal metabolism of the subject comprise a main line for a sampling flow of the air exhaled by a subject who breathes spontaneously or a subject undergoing assisted pulmonary ventilation. A mixing mini-chamber is provided for mixing a plurality of air sampling flows exhaled by the subject within a number of respiratory cycles. Sensors for sensing the oxygen concentration and the carbon dioxide concentration respectively measure the oxygen concentration and the carbon dioxide concentration within the air flow in the main line. The device further comprises an electronic control unit which processes signals from the sensors for obtaining a measurement of metabolism of the subject within a number of respiratory cycles.

Abstract: A spirometer for correlating test results with other user date to indicate a relationship, said spirometer comprising: (a) a processor; (b) memory operatively connected to said processor and configured with instruction to instruct the processor to perform the following steps: (i) recording spirometer results of a user; (ii) correlating said results with user data, said user data comprising at least one of a medication log, a medical diary, a baseline performance for said user provided by a healthcare provider, or other results from other testing devices; and (iii) indicating a relationship between said results and said user data.

Abstract: An airway adaptor includes: an airway case; and an expired gas guiding portion which is connected to the airway case to introduce a respiratory gas to the airway case. The airway case includes: a first respiratory gas flow path in which the respiratory gas flows in a first direction; and a second respiratory gas flow path in which the respiratory gas flows in a second direction opposite to the first direction.

Abstract: Systems and methods for prompting a user to perform an exercise and monitoring the exercise are provided. Multiple independent sensors or sensor systems may be used to calculate energy expenditure. Various criteria may be used to manually or automatically select the independent sensor or sensor system or combination that will be used with the energy expenditure calculations.

Abstract: Embodiments of a smart mobility aid device may have sensors to collect, monitor, analyze and represent data including but not limited to activity tracking, biometrics and safety and emergency features. The activity tracking include number of steps, miles, and activity speed, user pressure on a device, activity types and analysis. The user biometric data includes but is not limited to blood work, blood pressure, blood sugar, heart rate, oxygen level/rate, ECG, EMG, muscle strain, humidity, UV, body temperature. Additional features include an emergency button, fall detection, warnings, and user pattern analysis changes. The mobility aid device is connected to other smart electronic device and/or the Internet using but not limited to Bluetooth, Wi-Fi, and or/and SIM card. The device gives the user or/and caregiver live feedback about user health metrics and status using a data representation method.

Abstract: A footwear apparatus includes a sensor in the footwear apparatus positioned to monitor an activity technique of the user when the footwear apparatus is joined with a foot of the user and a feedback generator is arranged to produce at least one of a haptic communication or an optical communication to the user in response to detecting a pattern in the activity technique.

Abstract: An audiologic test apparatus includes: a processing unit; a tone generator connected to the processing unit; and a probe interface for connecting the audiologic test apparatus to a test probe; the tone generator configured to provide a first electrical signal representative of a first signal with a first primary frequency component at a first primary frequency; wherein the processing unit is configured to: obtain a first response signal, determine if a first insertion criterion is satisfied, the first insertion criterion based on the first signal and the first response signal, and generate a signal to initiate an audiologic test if at least the first insertion criterion is satisfied; the tone generator configured to provide a second electrical signal representative of a second signal with a second primary frequency component at a second primary frequency during the audiologic test, the first primary frequency being lower than the second primary frequency.

Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

Abstract: Analyte monitoring systems, devices, and methods associated with analyte monitoring devices, and devices incorporating the same are provided. Various graphical user interfaces (GUI) and navigation flows are provided for performing various features, activities, functions, etc., associated with the analyte monitoring device or system. Intuitive navigation is provided to enhance the interpretation of analyte measurements.

Abstract: Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

Abstract: Methods, devices, and kits are provided for mitigating single point failure of at least one device in an analyte monitoring system.

Abstract: A device for collecting a blood sample is provided. The device includes a collection unit, at least one capillary tube, a vacuum connector, and a storage unit. The collection unit has a top window for receiving the blood sample, a top surface, and a channel communicated with the top window. The at least one capillary tube is disposed in the collection unit and has a top end adjacent to the top window of the collection unit. The vacuum connector extends from the collection unit and communicates with the channel to provide a negative pressure by removing air in the channel. The storage unit is disposed under the collection unit for storing the blood sample.

Abstract: A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device. After transferring the blood sample, the biological fluid separation and testing device is able to separate the plasma portion from the cellular portion and analyze the blood sample and obtain test results.

Abstract: A biological body state estimation device configured such that a homeostatic function level is sorted and acquired in plural stages by using a biological signal obtained from an upper body of a person and each stage of the homeostatic function level is plotted in time series in accordance with a time axis indicated on the lateral axis and displayed as a graph by a display. A highest part on the vertical axis of the graph can be displayed as a highly active state and a lowest part as a function decline state. Therefore, a state of fluctuation due to autonomous nerves as an attempt to maintain homeostasis, progress of a feeling of fatigue, and a state stimulated by activation of the brain can be captured as a periodic function. Moreover, a sleep prediction phenomenon can be captured.

Abstract: An integrated device that detects and stores, in digital form, the muscle movements that occur when an operator traces a defined figure or pattern with a pointing device, such as a laser beam. The movement data is stored and analyzed for monitoring and diagnosing a neuromuscular condition or neuromuscular variations. Movement disorders can be determined and progression and change analyzed over time using the stored data.

Abstract: Described herein are systems and methods for personalized detection of an allergic reaction of a user. In one embodiment, a system includes an inward-facing head-mounted thermal camera (CAM) and a computer. CAM takes thermal measurements of a region on the nose (THN) of a user. The computer generates feature values based on THN and utilizes a model to detect an allergic reaction of the user based on the feature values. The model is trained based on previous THN of the user taken during different days. Some embodiments may utilize additional thermal cameras that take thermal measurements of other regions on the face, which may be utilized by the computer to generate additional feature values that are used to detect the allergic reaction. In some cases, detection of the allergic reaction may occur following a rise in nasal temperature, even before the user becomes aware of the allergic reaction.

Abstract: Provided are systems (100) and methods (200) for providing contact-less sleep disorder diagnosis, including a sound input device (103) and/or a movement detector (105) that receive sound and/or movement data originating from a patient in a sleeping environment, respectively. Also included is a computer-implemented device (109) that receives and stores the sound and/or movement data and determines a sleep disorder diagnosis based on the received data.

Abstract: A thermoelectric material includes a stretchable polymer, and a thermoelectric structure and an electrically conductive material that are mixed together with the stretchable polymer. The thermoelectric material may be applied to self-power generating wearable electronic apparatuses.

Abstract: Embodiments include method, systems and computer program products for automatic adjustment of helmet parameters based on a category of play. Aspects include monitoring a plurality of sensors in a helmet and determining the category of play for a user of the helmet based on data received from the plurality of sensors. Aspects further include automatically adjusting one or more parameters of the helmet based on the category of play.

Abstract: A wearable system configured to collect thermal measurements related to respiration. The system includes a frame configured to be worn on a user's head, and at least one non-contact thermal camera (e.g., thermopile or microbolometer based sensor). The thermal camera is small and lightweight, physically coupled to the frame, located close to the user's face, does not occlude any of the user's mouth and nostrils, and is configured to take thermal measurements of: a portion of the right side of the user's upper lip, a portion of the left side of the user's upper lip, and a portion of the user's mouth. The thermal measurements are forwarded to a computer that calculates breathing related parameters, such as breathing rate, an extent to which the breathing was done through the mouth, an extent to which the breathing was done through the nostrils, and ratio between exhaling and inhaling durations.

Abstract: A wearable system and methods for measuring physiological data from a device worn about a body part of a user is provided comprising a base module, a first sensor module, and a second sensor module. The base module comprises a display and a base computing unit. The first sensor module measures a gravitational force experienced by the device. The second sensor module is spatially positioned relative to the base module and over a portion of the body part for measuring one or more physiological characteristics calibrated based on the gravitational force measured with the first sensor module. The base module is adjustably positioned by the user relative to the second sensor module such that the sensor module maintains its positioning over the body part for sufficient contact with the body part for accurate measurements of physiological data regardless of the anthropometric size of the body part.

Abstract: A method for inspecting a pressure pulse wave sensor is provided. The sensor chip includes a recess which is recessed in a direction perpendicular to the pressure-sensitive face, and the pressure-sensitive element array is formed in a portion of the sensor chip whose thickness is reduced in the direction due to the recess. The method includes: bonding and fixing the sensor chip onto the substrate so that the recess communicates with atmospheric air through only the through hole of the substrate; connecting a substrate-side terminal portion of the substrate and the chip-side terminal portion through an electrically conductive member; and performing characteristic evaluation on the sensor chip based on a signal outputted from the substrate-side terminal portion in a state in which air is sucked through the through hole of the substrate to thereby apply negative pressure to the pressure-sensitive face.

Abstract: An outpatient ambulatory patient worn apparatus for managing chronic lung disease includes a plurality of sensors configured to be worn by a patient and to measure a plurality of physiological data. The plurality of sensors includes at least an oximeter, a respiratory rate sensor, and at least one activity or motion sensor. A central monitoring unit (CMU) is worn by the patient in an outpatient setting during activities of daily living. The CMU categorizes each recorded measurement of each of the plurality of sensors stored in a set of time stamped primary data by a predominate activity type to generate a set of activity type stamped data, the predominate activity types include rest, exertion, and sleep. A generate report process provides at least one or more reports. An outpatient ambulatory patient worn long-term oxygen therapy (LTOT) apparatus and a method for managing chronic lung disease are also described.

Abstract: A system for assessing risk associated with a suspected heart rhythm disorder includes at least one sensor for generating a signal received from a beating human heart over a plurality of time segments, and an analytic engine that receives the signal and calculates a change in the signal among at least a first time segment and a second time segment in response to a change in at least one of rate and regularity induced in the beating human heart. The analytic engine generates a risk score for the heart rhythm disorder based at least in part on the change in the signal. The system may further be configured to control modification of tissue of the beating human heart based on the risk score.