Abstract: The present disclosure relates to a medicament delivery device comprising: a housing configured to receive a cartridge containing a medicament; an injection needle having a proximal end and a distal end; an injection needle holder to which the injection needle is fixed, the injection needle holder being moveable relative to the housing between a rest position and a use position; and an injection needle cap detachably connected to the injection needle holder and enclosing the proximal end of the injection needle. The medicament delivery device is configured such that pushing the injection needle cap towards the cartridge causes the injection needle holder to move from the rest position in which the distal end of the injection needle is spaced from the cartridge towards the use position in which the distal end of the injection needle can engage the cartridge.

Abstract: An injection apparatus includes a hollow body having a first end at which a hollow needle is or can be located. A bung with a rupture seal membrane is located within the hollow body. A piston is also located within the hollow body. The piston, the hollow body and the bung define a volume containing a liquid medicament. The bung is nearer than the piston to the first end of the hollow body. The rupture seal membrane initially isolates the needle from the medicament. The rupture seal membrane is configured to rupture through fluid pressure alone without the rupture seal membrane contacting the needle, thereby allowing the medicament to be expelled through the needle upon movement of the piston causing the provision of pressure to the medicament.

Abstract: A medicament injection device comprising a main body arranged to receive a medicament cartridge; a needle carrier carrying a needle, wherein the needle carrier is axially movable with respect to the main body; and a rotatable cap at a distal end of the device, wherein the cap is removably coupled to the needle carrier, a releasable arrangement between the main body and the cap comprising a guide element and a slotted link, wherein the slotted link is arranged to cause the guide element to follow a predefined path at least partly in an axial direction during rotational movement of the cap, thereby causing the needle carrier to move axially towards a proximal end of the device as the cap is rotated up to a predefined point, wherein the main body comprises a medicament cartridge holder comprising the guide element depending therefrom for engagement with the cap.

Abstract: Provided is a fluid wicking tip. The fluid wicking tipi includes a plurality of drip flanges arranged to wick fluid between narrow spaces defined between any two drip flanges. The narrow spaces are dimensioned to facilitate wicking by capillary action. Also provided is a syringe that includes the fluid wicking tip. Also provided is a modular syringe system that includes a syringe and a sleeve configured to be slidably disposed over the syringe.

Abstract: A syringe packaging system that includes a tube and a cap for enclosing a pre-filled syringe is disclosed. The tube includes a tube cut flange and the cap includes a cut skirt. With a syringe barrel contained within the tube, a syringe barrel cut flange is aligned with the tube cut flange. With the pre-filled syringe enclosed within the tube and the cap, the cut skirt of the cap surrounds the syringe barrel cut flange. In one embodiment, a film is securable to a portion of the tube and a portion of the cap to connect the tube and the cap with the pre-filled syringe enclosed within the cap and the tube.

Abstract: The present invention relates to a medicament delivery device comprising a housing, which housing is arranged to accommodate a medicament container, a drive unit operably arranged to act on said medicament container for expelling a dose of medicament, the drive unit comprising a plunger rod, a force element operably connected to said plunger rod, a connector arranged to releasibly hold said plunger rod, an actuator element operably arranged to said connector and a manually operable actuator arranged to act on said actuator element for releasing said connector when operated. The invention is characterised in a safety device arranged to releasibly hold said actuator element in a locking position with said connector, preventing unintended release of said plunger rod.

Abstract: A syringe packaging system including a shell for enclosing a pre-filled syringe is disclosed. The shell includes a first portion having a proximal end and a distal end having a disk-shaped bottom portion; and a second portion having a proximal end and a distal end. With the first portion engaged with the second portion to form the shell, the proximal end of the first portion and the proximal end of the second portion together define a syringe flange having a top wall that defines a shell proximal aperture, a bottom wall, and a sidewall.

Abstract: The present invention provides a method for producing a syringe gasket which is improved in liquid drug sealability by forming a minute projection on a circumferential surface of the gasket after demolding the gasket. In a method for producing a syringe gasket including a cylindrical main body (2) made of an elastic material and an inert resin film (3) laminated on a surface of the main body (2), at least one minute projection (5) is formed as extending circumferentially of the gasket on a surface of the inert resin film (3) laminated on the main body (2) by thermal processing using a laser beam.

Abstract: A method of manufacturing a sealing element for use in a fluid conveyance device comprising the steps of: forming an elastomeric sealing body including a first body portion defining at least one annular sealing rib, and a second body portion arranged on an end of the first body portion, the second body portion comprising an annular protrusion extending radially beyond the first body portion; and forming a layer of barrier material on a free end of the second body portion, wherein the forming steps are carried out in a single molding operation.

Abstract: An injector device includes an injector body that receives a syringe; and an injection assembly being configured to dispense medicament from the syringe in a dispensation step. Certain types of injector devices include a sudden completion indicator that indicates when the injection is completed. Certain types of injector devices are configured to dispense two different medicament formulations having different viscosities from syringes without making any changes to the injector devices other than to switch out the syringes. Certain types of injector devices include safety arrangements that inhibit firing of the injector device until front and rear housing assemblies are disposed in predetermined rotational and axial positions relative to each other.

Abstract: A distribution assembly having a syringe having a body with a tip supporting a needle having a bevel, and a removable syringe needle protection device. The protection device has a flexible cap defining an inside cavity defined by a side wall and by a distal solid end wall, and when in the protection position, receiving the bevel of the needle in airtight manner. The side wall includes an annular bead provided with at least one slot extending across the bead in a longitudinal direction, the bead, when in the protection position, co-operating in airtight manner with the tip of the syringe. The cavity of the cap is dimensioned so that when the protection device is removed from the syringe, the cavity is connected to the atmosphere via the slot before the bevel of the needle becomes connected to the cavity.

Abstract: A drug delivery device comprises a cap releasably secured to a main body of the drug delivery device and a needle assembly retained within the cap. The drug deliver device also includes a pre-stressed biasing element disposed between the cap and the needle assembly and configured to bias the needle assembly in a distal direction with respect to the drug delivery device while the cap is secured to the main body. The drug delivery device further comprises one or more locking elements each having a locked position and an unlocked position. In the locked position, the locking elements prevent the needle assembly from engaging with a cartridge retained within the main body. In an initial position, the cap is configured to retain the locking elements in the locked position. In an intermediate position, the cap is configured to release the locking elements to allow the needle assembly to engage with the cartridge.

Abstract: The present invention relates to an auto-injector device (10) for delivering a liquid medicament, the auto injector comprising an injector body, a syringe (18) received in the injector body, a needle (17) disposed in a first end of syringe to extend toward an opening of the injector body, a needle shield (25) removeably attached to the syringe to enclose the needle and an injector cap removeably received in the opening of the injector body to enclose the needle shield. The injector cap (12) comprises at least one engaging element to engage with the needle shield and the needle shield comprises a rupture portion. The at least one engaging element is configured to rupture the rupture portion as the cap is removed from the body. The at least one engaging element is configured to engage with at least a portion of the needle shield to retain at least a portion of the needle shield in the cap when the cap is removed from the body.

Abstract: The present disclosure relates to an injection device. The injection device comprises a cap and a body for holding a syringe that has a needle at one end. The cap is removably attached to the body and comprises a needle shield to cover said needle. The injection device further comprises a configuration adapted to increase the gas pressure at an interface of the injection device that is disposed between the body and a portion of the cap to urge the body and said portion of the cap apart.

Abstract: An injection device comprises an injector body arranged for mounting a syringe with a needle shield; and a cap disposed at one end of the injector body. The cap comprises a main body with a first open end and a second closed end, the main body comprising one or more openings through an outer surface; and an engaging member disposed externally on the main body, which comprises one or more protruding elements arranged to extend inwards through the one or more corresponding openings in the outer surface of the main body and configured to engage with the needle shield.

Abstract: A cap remover for removing a cap covering a needle of a medical injector includes a body having an insertion portion at its a proximal end configured to at least partially accommodate the cap, and a grabbing portion at its distal end having an internal cavity which includes an extraction member having a series of laminas extending radially and inwardly from the ring.

Abstract: A device for safe and easy removal of a rigid needle shield from a syringe, said device comprising a wall with an inner and an outer surface, the inner surface of the wall defining a tubular hollow portion along the longitudinal axis of the a rigid needle shield, said inner wall comprising a recess adapted to receive a compressible gasket movable within said recess along said longitudinal axis from a portion of the recess wherein said gasket is in a relatively uncompressed state to a portion of said recess wherein said gasket is in a relatively compressed state compared to the relatively uncompressed state, wherein said recess is arranged so that the gasket grips the rigid needle shield in the compressed state.

Abstract: Apparatus for detecting and removing a gas mass from a vascular infusion line, the apparatus comprising: a cartridge, the cartridge comprising: an inlet port; a chamber having a top end, a bottom end and a side wall extending therebetween; an outlet port; a purge port; a first passageway connecting the inlet port to the side wall of the chamber with an upward inclination; a second passageway connecting the bottom end of the chamber to the outlet port; and a third passageway connecting the top end of the chamber to the purge port.

Abstract: This invention is designed and intended to provide simple, precise delivery of a variety of medications to mucosal surfaces of a living subject, human or non-human animal, including but not limited to the nasal or rectal mucosa, which sites afford rapid absorption and therefore onset of effect of the thus delivered medication. Such medications include, but are not limited to, anticonvulsants, drugs to treat anaphylactic shock, antidotes for poisoning, and medications which are required urgently where either a parenteral formulation is not available or an i.v. route is difficult. Simplicity and needle free safety of use of the various embodiments of the invention allows its operation by laypersons, school-teachers, nurses, paramedics and non¬medical persons in e.g. the armed service. Modular embodiments of the invention facilitate mixing and matching of delivery systems with different dosages and types of medications.

Abstract: A device for delivering a predetermined amount of a substance within at least one body cavity of a subject, where the predetermined amount is at an effective amount for treatment of obesity or binge eating disorder. The device comprises: (a) A volume to contain the predetermined amount of the substance. (b) A delivery end placeable in proximity to the body cavity. The delivery end is in fluid communication with the volume and comprises at least one orifice. (c) A valve mechanically connected to the volume, with at least two configurations: (i) an active configuration configured to deliver the predetermined amount of the substance; and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined amount of the substance. (d) A fluid tight chamber configured to contain a predetermined volume of pressurized gas at a predetermined pressure.

Abstract: According to one embodiment, a method includes positioning a trocar having a primary pressure sensor in or on the trocar into a patient cavity. The method also includes supplying an insufflation fluid to the patient cavity and measuring a pressure in the patient cavity by the primary pressure sensor. The method further includes controlling the supply of insufflation fluid by an insufflator to the patient cavity based at least on the measured pressure and determining by a processor associated with the insufflator that the measured pressure may be inaccurate and in response, controlling, by the insufflator, the supply of insufflation fluid to the patient cavity based at least on a pressure measured by a backup pressure sensor rather than based on the measured pressure.

Abstract: In an inhalation system (1) for inhalation of a dosing aerosol (6?), comprising: a dosing device (6) which delivers the aerosol (6?) a container (2) in which one or more chambers (4, 5) separated from one another and connected together during inhalation by means of one or more valves (8) are provided, with an inlet opening (7) emerging into the first chamber (4), into which opening the dosing device (6) is inserted, with the second chamber (5) having a first passage opening (9) which interacts with the respiratory openings of a human being (20), with the second chamber (5) having a second passage opening (10) that is connected to the surrounding air (15) and through which a positive pressure in the second chamber (5) can escape into the surrounding air (15) during exhalation, a simple and hygienic application of the inhalation arrangement (1) should be guaranteed and the aerosol flow should have a linear and rotating motion induced in it during the inhalation procedure.

Abstract: A dose unit including at least one isolated bioactive agent applied on a carrier material in thermal contact with an electrically heating element configured to vaporize a pre-determined amount of the agent for pulmonary delivery thereof is provided herein, as well as devices for effecting vaporization and pulmonary delivery of the isolated agent, and methods for preparing the dose unit, controllably releasing the agent therefrom, methods for pulmonary delivery thereof and methods of treatment of medical conditions treatable by pulmonary delivery of the isolated bioactive agent.

Abstract: A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 ?m, so as to target the pulmonary system of the user.

Abstract: An inhaler device for administering powdered pharmaceutical composition from capsules comprises of a base, a deck, a chamber, a mouthpiece and a cap. The deck can be latched to the base and closed off, and being connected to a push button (17) through a protrusion (22) and a sliding groove (16). The chamber is for holding the capsules and can be adjusted to be lowered into the base. The mouthpiece is latch-able to the deck. The cap covers the mouthpiece in a closed position and latches it by means of a closure element. The base, the deck, the mouthpiece are connected by means of a spindle. The cap is not connected to the rest of the device parts; instead, it is held together with the rest of the inhaler device by means of the protective shell (26) with a strip pattern (27) or a linking belt (29). Finally, there is a capsule-piercing unit with at least one piercing pin for piercing the capsule.

Abstract: The present disclosure generally relates to systems and methods for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a high frequency ventilator using at least enhanced therapeutic gas (e.g., nitric oxide, NO, etc.) flow measurement. At least some of these enhanced therapeutic gas flow measurements can be used to address some surprising phenomenon that may, at times, occur when wild stream blending therapeutic gas into breathing gas a patient receives from a breathing circuit affiliated with a high frequency ventilator. Utilizing at least some of these enhanced therapeutic gas flow measurements the dose of therapeutic gas wild stream blended into breathing gas that the patient receives can at least be more accurate and/or under delivery of therapeutic gas into the breathing gas can be avoided and/or reduced.

Abstract: A method and system for assisting clinicians in determining when and how to perform a lung recruitment procedure. The method includes a user configurable interface that an operator or institution can set up to correspond to best practices. Based upon the information entered into the configurable user interface, a method and algorithm automatically determines when a lung recruitment procedure should be instituted. The system can either manually or automatically enable the beginning of the lung recruitment procedure depending upon the clinician and facility preferences. The algorithm includes a plurality of process steps that are carried out in a clinically-relevant order to eliminate patient condition options and to provide the appropriate recommended actions prior to initiating the lung recruitment procedure.

Abstract: A ventilator, for the automated ventilation of a patient, includes a breathing gas delivery unit, at least one volume flow sensor for detecting a volume flow of the breathing gas, at least one breathing gas sensor for detecting a carbon dioxide concentration in the breathing gas, at least one pressure sensor for detecting a pressure of the breathing gas, as well as at least one computer. The computer is configured to actuate the breathing gas delivery unit as a function of the detected pressure and of a preset desired pressure value. The computer is further configured to perform an adaptation of the desired pressure value and an adaptation of a ventilation rate as a function of the detected volume flow and as a function of the detected carbon dioxide concentration.

Abstract: A secure endotracheal tube holder is provided that is specifically designed to securely hold an endotracheal tube in the neonatal population and that provides stability when used with tape. It is easy to use and replaces non-approved devices such as the post manufacture-modified umbilical cord clamp, which were not intended for securing the endotracheal tube or other products on the market that have high extubation rates. The taberculated inside surfaces of the opening hold the tube in place while a lateral curve provides for easier handling when securing to the face with tape or when the tube requires adjustment. The device is clearly marked with appropriate numeric size indicating the tube size along with a color scheme for visual recognition, and it is constructed from clear or colored plastic to facilitate seeing the markings and depth.

Abstract: A respiratory interface apparatus and method for treating a patient requiring continuous positive pressure ventilation is provided. The interface can create a cylindrical stream of air, or vortex, which forms a respiratory seal with the nostrils of the patient for the transmission of pressurized air therethrough. The vortex air seal is created by annular flow nozzles which tangentially direct pressurized air in a cylindrical pattern extending into the nostrils of the patient. A separate, continuous flow of pressurized air is then transmitted through the cylindrical air seal and into the patient's airway. The air seal which is created allows the patient to receive pressurized air without having to wear a tight fitting mask. The inventive interface can include air pressure sensors and/or microprocessors for tailoring therapy to a particular patient, and can be connected to a standard CPAP machine and delivery tubing for respiratory therapy previously requiring an air-tight seal with the patient.

Abstract: An oxygen face mask with capnometer and side port is used in sedated patients undergoing endoscopy or transesophageal echocardiography. The mask can include an elliptical insertion port to maximize access to the oral opening for performing procedures as well as making it easier for awake patients to eat and drink. A reinforcement elliptical band can tent the mask up to enhance oral access. A set of keyhole notches can keep the nasal cannula out of eyes, secures the mask to the face and allows for easy partial/full removal of mask with tactile feedback. An oxygen inflow port may be located laterally, away from the oral opening. The mask can include an attachment pin design that provides easy removal and reapplication when one side of patient's face is turned away from the anesthesiologist. The mask can include carbon dioxide sampling ports to allow for CO2 monitoring from left or right.

Abstract: Portable oxygen concentrator elements are described including integrated sensor/accumulator assemblies, new muffler designs, and improved airflow and internal gas connectivity. The result of the elements is an extremely compact, light reliable portable oxygen concentrator that is easy to assemble and relatively inexpensive.

Abstract: An apparatus and method for resuscitating a patient suffering from cardiac arrest or another condition in which normal circulation has been interrupted. A ventilator is used for delivering a gas mixture to the patient. The ventilator is configured to adjust the partial pressure of CO2 to one or more partial pressures high enough to slow expiration of CO2 from the patient's lungs and thereby maintain a reduced pH in the patient's tissues for a period of time following return of spontaneous circulation.

Abstract: A positive pressure gas supply system includes a CPAP unit a humidifier support housing with a receiving portion. The receiving portion is bound by a bottom wall with a heater and at least one side wall extending vertically from the bottom wall. A gas feed opening in the at least one side wall is in fluid communication with a gas feed path from the CPAP unit. A refilling module configured to retain a body of water is removably placed within the receiving portion from a location above the receiving portion so that a metallic part of the refilling module contacts the heater when the refilling module is resting on the bottom wall of the receiving portion. In addition, a sealing device is configured to seal off the refilling module in the receiving portion. The sealing device and the refilling module are removable as a unit from the humidifier support housing.

Abstract: A respiratory assistance apparatus includes a flow generator and a humidifier. The humidifier includes a humidification chamber. The humidification chamber comprises a water tub that is configured to receive a volume of water. A lid is hingedly coupled to the water tub for enclosing a volume contained within the water tub.

Abstract: An anesthetic delivery system for use in conjunction with an anesthetic return system for reutilizing anesthetic exhaled by a subject, the system including a measurement system operatively connected to a breathing circuit for continuously measuring at least one flow parameter and anesthetic content of a gas stream reaching the subject and a control system for receiving input from the measurement system and controlling the amount of anesthetic entering the system, the control system including an input device for inputting a setting that corresponds to a desired amount of anesthetic in the gas stream reaching the subject, and utilizing a control algorithm for controlling the amount of anesthetic entering the system based on said desired amount of anesthetic, and flow and anesthetic content parameters as determined by the measurement system, such that the control algorithm is adapted to supplement anesthetic already in gas stream flowing to the subject to attain a level of anesthetic reaching the subject that co

Abstract: A context-sensitive soundscape is generated by receiving a first identifier for identifying a target cognitive state for a user, and a second identifier for identifying a user cohort for the user. A present context is determined for the user. A machine-learning procedure is performed to map the target cognitive state to a set of audio output characteristics based upon the identified user cohort and the determined present context. An audio output is generated to create the context-sensitive soundscape that includes the set of audio output characteristics.

Abstract: An example system for mitigating motion sickness within a vehicle is provided. The system includes a motion sickness mitigation device (MSMD) integrated into the vehicle and configured to generate electrical stimulation pulses upon actuation. The system also includes a controller operatively connected to the MSMD. The controller is configured to: obtain signals indicative of a potential motion sickness condition; determine whether a motion sickness conditions exists based on the signals; and, in response to determining that a motion sickness condition exists, actuate the MSMD.

Abstract: An aspect of some embodiments of the application relates to a microcatheter comprising a deployment element disposed about around at least a portion of an exterior of a distal end of the microcatheter, the deployment element configured for repeatedly expanding and collapsing, the distal end arranged to allow forward or reverse axial displacement while the deployment element maintains a position, the deployment element arranged for positioning the microcatheter distal end approximately in the middle of a vessel.

Abstract: A medical elongated body is disclosed, which includes a shaft having a lumen through which a contrast agent can flow; and a tubular structure portion which is provided at a distal portion of the shaft and has an insertion hole. The tubular structure portion includes an inner tube fixed to the distal portion of the shaft; an outer tube which is disposed radially outward of the inner tube and is liquid-tightly fixed to the distal portion of the shaft and a proximal portion of the inner tube; a space portion communicating with the lumen of the shaft between the inner tube and the outer tube, and an opening portion through which a contrast agent flows from the lumen into the space portion flows out.

Abstract: A method for insertion, maintenance, and removal of urethral catheters in mammals including humans includes steps for preventing or reducing the incidence of catheter associated urinary tract infections. In addition to sterile procedures currently practiced or as may be practiced in the future in connection with catheter use, the method includes the steps of applying an antiseptic, zwitterionic, and acidic skincare solution capable of preserving the stratum corneum to the perineum, meatus, and contiguous mucosa surrounding the insertion site before insertion, after insertion, periodically during the period of indwelling, in connection with any incidence of incontinence, and, optionally, before and after removal of the catheter. Application of the solution optionally is continued after catheter removal on a periodic basis until the threat of an infection associated with catheter use has passed, typically at least about five (5) to seven (7) days and up to thirty (30) days.

Abstract: A catheter with a dedicated flushing port has a flushing port that allows the practitioner to irrigate an inserted catheter to remove blood clots and other substances from the patient without removing the drainage tube. A holder keeps the flushing port clean and while not in use. A drainage bag with a large spout is provided to allow easy empting of the drainage bag. In one embodiment, the flushing port is integrated as part of the catheter. In another embodiment, the flushing port is part of the drainage tubing and in another embodiment, the flushing port is provided as an attachment piece that fits between the catheter and the drainage tubing. The drainage bag has a handle that allows the user to tip the bag to empty.

Abstract: This invention concerns urinary catheterizing and identifies a cavitation occurring at catheter removal as the source of a damaging problem, and shows that a vent to atmosphere of the catheter tip prior to the catheter and vent removal prevents this problem. This invention disclosure shows the vent and method to prevent this problem. The prior art for self-catheterizing specifies six catheterizes and catheter removals per day. Each catheter removal causes a small amount of damage, damage is cumulative and enlarges at subsequent catheterizes. After many catheterizes, the enlarged damage at catheter removal causes a serious bleeding problem. This invention has two cooperative parts related in time as early and later. The early part inserts a lubricated catheter to urethra and bladder to remove urine, and the later part inserts a vent to a catheter urine discharge lumen and catheter tip to prevent this problem at the catheter and vent removal.

Abstract: A catheter is disclosed, which includes an inner tube, and a coil tube disposed on an outer peripheral side of the inner tube, the inner tube being a coil obtained by winding a wire. In addition, in the coil tube, a first coil and a second coil are arranged concentrically with each other. The first coil and the second coil have mutually different winding directions of the wire. Then, the inner tube and the coil tube are rotatable relative to each other around a central axis of the coil tube. In addition, in a natural state where no external force is applied to the catheter, a gap is formed between the inner tube and the coil tube.

Abstract: A catheter assembly includes a catheter, a hub, and a sealing member. The catheter defines one or more lumens. The hub includes one or more hub extensions dimensioned to be received within the one or more lumens of the catheter. The sealing member is positioned adjacent the interface of the catheter and the hub. The sealing member includes an expandable material which increases in volume upon exposure to moisture.

Abstract: A pneumatic device for holding and moving an elongate object, includes an annular hollow body through which the object passes and which is composed of two end parts forming jaws and a median segment connecting the two jaws to each other, with ease of movement of one with respect to the other under the effect of a controlled deformation of at least one portion of the median segment, where the various parts of the hollow body define respective chambers, the jaws have elastically deformable internal membranes, in the chambers of the two end parts are in fluidic communication with the chamber of the median segment, in each case by way of at least one respective calibrated flow element, the injection of pressurized gaseous fluid being effected by way of a single feed line.

Abstract: An apparatus includes a cannula assembly and a sensor assembly. The cannula assembly includes a proximal end, a distal end, and a first lumen extending from the proximal end to the distal end. The cannula is formed of a rigid material. The sensor assembly includes a sensor and a communication wire. The sensor is fixed to the cannula assembly. The communication wire is in electrical communication with the sensor. The communication wire extends along a length of the cannula assembly exterior to the first lumen.

Abstract: An introducer has a shaft with a central lumen, a control handle with a deflection assembly, and a tensile member with a distal portion extending along opposing sides of within the shaft and a proximal portion extending within the control handle. The deflection assembly has a deflection arm, and a rotatable member rotationally coupled to the deflection arm, wherein the rocker member has at least one pulley engaged with the proximal tensile member portion. Rotation of the deflection arm in one direction draws the proximal tensile member portion for deflecting the shaft.

Abstract: Articulation devices, such as comprising pull rings, are provided having improved or increased visibility under conventional visualization techniques, such as fluoroscopy. Such improved visibility is achieved by the presence of at least one insert comprised of a material that is more visible or detectable under imaging techniques than the pull ring. The at least one insert is positionable within a cut-out in the articulation device and fixed into place by a suitable method such as adhesive, soldering, swaging, welding, laser welding, etc. The insert resides within the dimensions of the walls of the pull ring so as to not increase the outer diameter or decrease the inner diameter of the pull ring. This maintains the profile of the overall articulation device.

Abstract: Deflectable catheters, hemostasis valves, and materials for the same are disclosed. The deflectable catheters and hemostasis valves can be made at least partially, if not entirely, from a fluoroelastomer and ePTFE combination. A deflectable region of the catheters can be articulated to form simple and/or complex curves.