Patents Issued in December 13, 2018
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Publication number: 20180354864Abstract: The present invention relates to the field of foam formation and stabilization, particularly foamed construction materials, such as cement. Disclosed are additives suitable to obtain mineral foams when added to the corresponding starting materials. The invention provides a ready-to-use product in the form of a solid particulate composition comprising hydrophobized particles (1) and catalytically active particles (2) as defined in claim 1. The invention further provides for manufacturing methods of such ready-to-use product.Type: ApplicationFiled: August 30, 2016Publication date: December 13, 2018Applicant: DE CAVIS AGInventors: Urs T. Gonzenbach, Philip Noah Sturzenegger
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Publication number: 20180354865Abstract: The invention discloses a sound-absorbing material particle and a preparation method thereof. The preparation method comprises the following steps: step 1, mixing a sound-absorbing raw material with a templating agent and water to prepare a sound-absorbing slurry, filling a reaction kettle with a porous ceramic substrate and the sound-absorbing slurry that are mixed together; step 2, performing hydrothermal crystallization in the reaction kettle to ensure that the sound-absorbing raw material is crystallized on the porous ceramic substrate and constitutes the sound-absorbing material particle together with the porous ceramic substrate; step 3, performing solid-liquid separation on the materials in the reaction kettle; and step 4, drying and roasting the sound-absorbing material particle.Type: ApplicationFiled: May 18, 2016Publication date: December 13, 2018Inventor: Xiaodong Cao
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Publication number: 20180354866Abstract: An article comprises a substrate comprising a ceramic matrix composite; a first layer disposed over the substrate, the first layer comprising a substantially interconnected silicon source material, and a secondary material; and a second layer disposed over the first layer, the second layer comprising a membrane material in mass transfer communication with the silicon source material.Type: ApplicationFiled: May 24, 2018Publication date: December 13, 2018Inventor: Krishan Lal Luthra
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Publication number: 20180354867Abstract: Methods of producing a treated gas by removing nitrogenous compounds are disclosed. Methods of recovering nitrogenous compounds from a gas stream are disclosed. Methods of producing a fertilizer product from organic waste are disclosed. The methods may include introducing a gas stream having nitrogenous compounds into a nitrogenous liquid containing a salt of ammonia to absorb the nitrogenous compounds in the liquid and produce a treated gas. The methods may also include controlling the pH of certain solutions or introducing an oxidant into certain solutions to produce nitrogen ions. Systems for removing nitrogenous compounds including a reaction subsystem, an oxidation control subsystem, a dissolved solids concentrator, and a recirculation line are also disclosed. The systems may be employed to remove nitrogenous compounds from a gas stream, recover the nitrogenous compounds from the gas stream, or produce a fertilizer product from the recovered nitrogenous compounds.Type: ApplicationFiled: January 16, 2018Publication date: December 13, 2018Inventors: Eugenio Giraldo, Barbara Jean Wingler, Gabriel Howard Giraldo-Wingler
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Publication number: 20180354868Abstract: A method for producing a co-polymer of fulvic acid and poly-metallic humates (CPFAPH) including performing a decomposition reaction via electrolysis of an initial water substratum to produce an end product comprising hydrolyzates; and performing a polymerization of the hydrozylates.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Inventors: Igor Taganov, Anita Paldanius, Matti Tiainen
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Publication number: 20180354869Abstract: The present invention provides an organic-inorganic polymeric water-retaining fertilizer. The organic-inorganic polymeric water-retaining fertilizer is a co-polymer made by fusion and co-polymerization of an organic water-retaining monomer and an inorganic nutrient under action of a catalyst, a biological enzyme and a modifying agent. The co-polymer is of a three-dimensional mesh-like hydrophilic group structure. In a method for preparing the organic-inorganic polymeric water-retaining fertilizer, after obtaining a neutralized pre-polymer from the organic water-retaining monomer under the action of the catalyst, an initiator and a cross-linking agent are added; the inorganic nutrient and a metasilicate are added simultaneously, a solution is formed by stirring sufficiently; the biological enzyme is added for catalysis; a co-polymer is obtained after fusion and co-polymerization; and granulation and drying are carried out. Preferably, the catalyst is an inorganic alkaline solution.Type: ApplicationFiled: June 30, 2017Publication date: December 13, 2018Inventors: Yanfang ZHU, Zhiyong DU, Hongzhi ZHU
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Publication number: 20180354870Abstract: Described here are various processes for producing linear alpha olefins using a heterogeneous catalytic composition in the reaction mixture. These processes include size-based or phase-based separation of the heterogeneous catalytic compositions from the product stream and recycling the catalysts to the reaction mixture. Various other embodiments may be disclosed and claimed.Type: ApplicationFiled: March 14, 2018Publication date: December 13, 2018Inventors: Xu Wei, Kareemuddin Shaik, Zhonglin Zhang, Rodrigo Sandoval Rivera, Sohel Shaikh, Hussain Yami
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Publication number: 20180354871Abstract: Disclosed are a system device for preparing an alkylate oil using a sulfuric acid catalyst and a manufacturing method thereof. The system device comprises a reactor unit (100), a catalyst and hydrocarbon circulation unit (200), a separator unit (300), an isobutane circulation unit (500) and a fractionator unit (400). The reactor unit (100) is connected and in communication with the catalyst and hydrocarbon circulation unit (200) and the separator unit (300) via channels respectively. The catalyst and hydrocarbon circulation unit (200) is connected and in communication with the separator unit (300) via channels. The separator unit (300) is connected and in communication with the isobutane circulation unit (500) and the fractionator unit (400) via channels respectively. The catalyst and hydrocarbon circulation unit (200), the separator unit (300), the isobutane circulation unit (500) and the fractionator unit (400) are connected and in communication with the reactor unit (100) via channels respectively.Type: ApplicationFiled: May 20, 2016Publication date: December 13, 2018Inventors: Haikui Zou, Guangwen Chu, Jianfeng Chen, Yong Luo, Baochang Sun, Yang Xiang
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Publication number: 20180354872Abstract: A) provision of a feed gas stream a comprising n-butenes; B) introduction of the feed gas stream a comprising n-butenes and an oxygen-comprising gas into a dehydrogenation reactor and oxidative dehydrogenation of n-butenes to butadiene; C) cooling and compression of the product gas stream b in at least one cooling stage comprising a quenching column and in a compression stage comprising a compressor, with the product gas stream b being brought into contact with at least one circulated coolant; D) separation of incondensable and low-boiling gas constituents as gas stream d2 from the gas stream c2 by absorption of the C4-hydrocarbons in at least one circulated absorption medium; E) separation of the C4 product stream d1 by extractive distillation using a solvent which is selective for butadiene into a stream e1 comprising butadiene and the selective solvent and a stream e2 comprising n-butenes; F) distillation of the stream e1 comprising butadiene and the selective solvent to give a stream f1 consisting essentiType: ApplicationFiled: December 2, 2016Publication date: December 13, 2018Inventors: Jan Pablo JOSCH, Ragavendra Prasad BALEGEDDE RAMACHANDRAN, Philipp GRUENE, Steffan RISSEL, Martin GEMBALA, Ulrike WENNING, Anton WELLENHOFER, Christine TOEGEL, Hendrik REYNEKE
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Publication number: 20180354873Abstract: Provided is a method for producing aromatic hydrocarbons from light alkanes. A light alkane feed is contacted with catalyst particles in each of reactors, wherein each of the reactors is a fluidized bed reactor and arranged in parallel with each other in a furnace. At least a portion of the alkane feed is converted to aromatic hydrocarbons using the catalyst particles, wherein the aromatic hydrocarbons form a part of a reactor effluent stream. The reactor effluent streams from each of the reactors are merged to form a first merged effluent stream. The first merged effluent stream is separated into the aromatic hydrocarbons, light hydrocarbons, and a fuel gas.Type: ApplicationFiled: December 29, 2017Publication date: December 13, 2018Inventor: Jin Ki HONG
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Publication number: 20180354874Abstract: There is provided an efficient method for producing 1-chloro-2,3,3,3-tetorafluoropropene, with fewer by-products such as 2,3,3,3-tetrafluoropropene and 1,1,1,2-tetrafluoropropane which are over-reduced products, in a method of obtaining 1-chloro-2,3,3,3-tetorafluoropropene by reducing 1-1-dichloro-2,3,3,3-tetrafluoropropene. A method for producing 1-chloro-2,3,3,3-tetrafluoropropene, comprising: reacting 1,1-dichloro-2,3,3,3-tetrafluoropropene with hydrogen in a gas phase in the presence of a palladium catalyst-carrying carrier in which a palladium catalyst having a specific surface area of 40 m2/g or less is carried on a carrier.Type: ApplicationFiled: August 20, 2018Publication date: December 13, 2018Applicant: AGC Inc.Inventors: Shingo Nomura, Hidekazu Okamoto, Hirokazu Takagi
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Publication number: 20180354875Abstract: An azeotropic or quasi-azeotropic composition including hydrogen fluoride, E-3,3,3-trifluoro-1-chloropropene and optionally one or more (hydro)halogen-carbon compounds including between 1 and 3 carbon atoms. Also, a preferred azeotropic or quasi-azeotropic composition including hydrogen fluoride, E-3,3,3-trifluoro-1-chloropropene, and optionally one or more compounds selected from among 1,1,1,2,2-pentafluoropropane, 2,3,3,3-tetrafluoropropene, 3,3,3-trifluoropropene, 3,3,3-trifluoro-2-chloropropene, 1,3,3,3-tetrafluoropropene, trifluoropropyne, 1,1,1,3,3-pentafluoropropane, 1,1,1,3,3-pentafluoropropane, 1,1,1,3,3-pentafluoropropene, 1,1,1,2,3-pentafluoropropene and 2-chloro,1,1,1,2-tetrafluoropropane.Type: ApplicationFiled: August 13, 2018Publication date: December 13, 2018Applicant: Arkema FranceInventors: Philippe Bonnet, Bertrand Collier, Dominque Deur-Bert, Laurent Wendlinger
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Publication number: 20180354876Abstract: There is described a method of preparing a compound of formula I, and optical isomers thereof; in which R1 is hydrogen or a protecting group; said method comprising oxidising verbenone and optical isomers thereof.Type: ApplicationFiled: December 2, 2016Publication date: December 13, 2018Applicant: e-Therapeutics plcInventors: Vijaya Bhasker Gondi, James Thomson Loch, III, Nicholas John Holman, Steven James Collier
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Publication number: 20180354877Abstract: A method for producing methanol includes obtaining reformed gas by subjecting raw material gas containing methane to partial oxidation reforming by use of oxygen; reducing a CO/CO2 ratio in the reformed gas; and obtaining produced gas containing methanol from the reformed gas with the reduced CO/CO2 ratio by using any of a fixed-bed reactor and an isothermal reactor.Type: ApplicationFiled: November 11, 2016Publication date: December 13, 2018Applicant: Mitsubishi Heavy Industries Engineering, Ltd.Inventor: Mikiya Sakurai
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Publication number: 20180354878Abstract: The process for preparing 1,2-propanediol from propene and hydrogen peroxide comprises the steps of a) reacting propene with hydrogen peroxide in the presence of a catalyst mixture comprising a phase transfer catalyst and a heteropolytungstate, wherein the reaction is carried out in a liquid mixture comprising an aqueous phase having a pH of at most 6 and an organic phase, b) separating the biphasic mixture from step a) into an aqueous phase and an organic phase comprising propene oxide, c) recycling the propene oxide present in the separated organic phase into the reaction of step a) and d) separating 1,2-propanediol from the aqueous phase separated in step b).Type: ApplicationFiled: November 1, 2016Publication date: December 13, 2018Applicant: EVONIK DEGUSSA GMBHInventors: Holger Wiederhold, David BOLZ, Bernd JAEGER, Hnas-Jürgen KÖHLE, Sebastian IMM, Georg Friedrich THIELE
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Publication number: 20180354879Abstract: The invention relates to a novel organic solubilisation and/or extraction solvent comprising at least one compound selected from the group of saturated monocyclic terpenoids, to an extraction method using said solvent, and to extracts obtained by said method. More particularly, the invention relates to a novel use of para-menthane, a saturated terpenoid compound, as a solvent derived from natural substances, and also to a solvent comprising para-menthane.Type: ApplicationFiled: October 13, 2016Publication date: December 13, 2018Inventors: Natacha ROMBAUT, Anne-Sylvie FABIANO TIXIER, Simona BIRTIC, Antoine Charles BILY, Marc ROLLER, Farid CHEMAT
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Publication number: 20180354880Abstract: The present invention is a method for producing a cyclopentyl alkyl ether compound represented by formula (1): R1—O—R2 (wherein, R1 represents an alkyl group having 1 to 10 carbon atoms that may have a substituent or a cycloalkyl group having 3 to 8 carbon atoms that may have a substituent, and R2 represents a cyclopentyl group that may have a substituent), wherein a cyclopentene that may have a substituent is reacted with an alcohol compound represented by formula (2): R1OH (wherein R1 represents the same as described above) in the presence of an acidic zeolite having a silica/alumina ratio of 80 or higher. The present invention provides a method for producing a cyclopentyl alkyl ether compound, wherein a reaction can be carried out in a liquid phase, catalyst activity is less lowered over time (long catalyst life), and a desired cyclopentyl alkyl ether compound can be continuously produced with high reaction efficiency and long-term stability even when a large amount of raw material is fed.Type: ApplicationFiled: December 16, 2016Publication date: December 13, 2018Applicant: ZEON CORPORATIONInventors: Naoto KOGOSHI, Takashi SASANUMA
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Publication number: 20180354881Abstract: Provided are integrated processes for the conversion of beta propiolactone to acrylic acid. Systems for the production of acrylic acid are also provided.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Applicant: Novomer, Inc.Inventors: Jay J. FARMER, Peter GALEBACH, Kyle SHERRY, Sadesh H. SOOKRAJ
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Publication number: 20180354882Abstract: Provided are integrated processes for the conversion of beta propiolactone to acrylic acid. Systems for the production of acrylic acid are also provided.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Applicant: Novomer, Inc.Inventor: Sadesh H. SOOKRAJ
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Publication number: 20180354883Abstract: A system and method for the conversion of a levulinate ester to maleic anhydride using a reducible oxide catalyst. Levulinic acid oxidation delivers maleic anhydride in good yields without viscosity and stability issues that make continuous production problematic. Due to the fact that levulinate esters are more amenable to processing, the conversion of levulinate esters to maleic anhydride represents an appropriate for the commercial production of maleic anhydride from renewable resources.Type: ApplicationFiled: June 8, 2018Publication date: December 13, 2018Applicant: SYRACUSE UNIVERSITYInventors: Jesse Quentin Bond, Anargyros Chatzidimitriou
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Publication number: 20180354884Abstract: A process for producing acetic acid comprises a process comprising: (1) carbonylating methanol; (2) separating the reaction mixture into a volatile phase and a less-volatile phase; (3) distilling the volatile phase to form a first overhead rich in a lower boiling component, and an acetic acid stream rich in acetic acid; and at least one step group selected from the group consisting of the following sections (4), (9), and (15): (4) a section for separating impurities from the acetic acid stream to give purified acetic acid, (9) a section for separating the first overhead into a stream rich in acetaldehyde and a stream rich in methyl iodide, and (15) a section for absorption-treating an off-gas from the process with an absorption solvent and forming a carbon monoxide-rich stream and an acetic acid-rich stream.Type: ApplicationFiled: November 17, 2017Publication date: December 13, 2018Applicant: Daicel CorporationInventors: Masahiko SHIMIZU, Yoshihisa MIZUTANI, Hiroyuki MIURA
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Publication number: 20180354885Abstract: Provided is a production method whereby corresponding carboxylic acid esters can be obtained from a variety of carboxylic acids at a high yield, even under conditions using a simple reaction operation and little catalyst and even if the amount of substrate used is theoretical. A production method for carboxylic acid ester, whereby a prescribed diester dicarbonate, carboxylic acid, and alcohol are reacted in the presence of at least one type of magnesium compound and at least one type of alkali metal compound.Type: ApplicationFiled: December 11, 2015Publication date: December 13, 2018Applicant: Mitsubishi Chemical CorporationInventors: Akihiro GOTO, Yoshihiro KAMON, Hiroyuki MORI
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Publication number: 20180354886Abstract: The present invention discloses a novel eco-friendly, cost effective, autocatalytic process for the synthesis of tributyl citrate (TBC) with high yields and purity.Type: ApplicationFiled: November 17, 2016Publication date: December 13, 2018Inventor: Sanjay Pandurang KAMBLE
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Publication number: 20180354887Abstract: A process for preparing a diaryl carbonate from a dialkyl carbonate and an aryl alcohol is disclosed. The process takes place in apparatus comprising at least two distillation columns, and at least one of the distillation columns is operated at subatmospheric pressure which is achieved using vacuum equipment.Type: ApplicationFiled: November 24, 2016Publication date: December 13, 2018Inventors: Kunquan YU, Garo Garbis VAPORCIYAN
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Publication number: 20180354888Abstract: The present invention relates to lipid comprising docosapentaenoic acid and/or docosahexaenoic acid preferentially esterified at the sn-2 position of triacylglycerol, and processes for producing and using the lipid.Type: ApplicationFiled: May 17, 2018Publication date: December 13, 2018Inventors: James Robertson Petrie, Surinder Pal Singh, Pushkar Shrestha, Jason Timothy McAllister, Robert Charles de Feyter, Malcolm David Devine, Xue-Rong Zhou
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Publication number: 20180354889Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.Type: ApplicationFiled: December 8, 2016Publication date: December 13, 2018Inventors: Florian Karl KLEINBECK-RINIKER, Benjamin MARTIN, Gerhard PENN, Francesco VENTURONI, Thierry SCHLAMA, Thomas RUCH, Thomas ALLMENDINGER, Bernhard WIETFELD, Paolo FILIPPONI
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Publication number: 20180354890Abstract: The method for producing trans-rich-1,4-bis(aminomethyl)cyclohexane includes blending 1,4-bis(aminomethyl)cyclohexane with an alkali metal compound and XDA and heating the mixture to isomerize 1,4-bis(aminomethyl)cyclohexane so that the trans isomer content relative to the cis/trans isomers in total is more than 70 mass %, and purifying the isomerized 1,4-bis(aminomethyl)cyclohexane by distillation after the isomerization step. The alkali metal compound is at least one compound selected from the group consisting of alkali metal hydride, alkali metal amide, and alkyl alkali metal. In the isomerization step, 0.Type: ApplicationFiled: December 9, 2016Publication date: December 13, 2018Inventors: Aya NAKAGAWA, Tetsuya HAMADA
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Publication number: 20180354891Abstract: Process for manufacturing a crystalline alkali metal salt of the general formula (I) [R1—CH(COO)—N(CH2—COO)2]M13 (I) wherein M1 is selected from alkali metal cations, same or different, R1 is selected from C1-C4-alkyl and CH2CH2COOM1, comprising the step of (b) crystallizing said alkali metal salt from an aqueous solution containing in the range of from 5 to 30% by weight of alkali metal hydroxide, referring to said aqueous solution.Type: ApplicationFiled: December 7, 2016Publication date: December 13, 2018Applicant: BASF SEInventors: Constanze FRANZKE, Axel FRANZKE, Armin STAMM, Markus HARTMANN, Robert BAUMANN
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Publication number: 20180354892Abstract: A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCl HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.Type: ApplicationFiled: May 7, 2018Publication date: December 13, 2018Applicant: TYRX, Inc.Inventors: Satish Pulapura, Fatima Buevich, Xiangji Chen, Suping Lyu
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Publication number: 20180354893Abstract: A method for transporting inventory items includes moving a mobile drive unit to a first point within a workspace. The first point is a location of an inventory holder. The method further includes docking the mobile drive unit with the inventory holder and moving the mobile drive unit and the inventory holder to a second point within the workspace. The second point is associated with conveyance equipment. The method further includes moving the inventory holder to a third point within the workspace using the conveyance equipment.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Inventors: Peter R. Wurman, Raffaello D'Andrea, Michael T. Barbehenn, Andrew Edward Hoffman, Michael Cordell Mountz
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Publication number: 20180354894Abstract: The present invention provides a process for producing an isocyanate compound such as 3-methyl-2-methoxymethyl-1-isocyanate benzene and the like. By reacting 3-Methyl-2-methoxymethyl aniline and the like with phosgene in the presence of a tertiary amine at 10° C. to 14° C. in one or more solvents selected from the group consisting of toluene and xylene, isocyanate compounds such as 3-methyl-2-methoxymethyl-1-isocyanate benzene and the like can be produced at high yield.Type: ApplicationFiled: December 14, 2016Publication date: December 13, 2018Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: Takashi MIYAMOTO, Yuta NAGASHIMA, Masaji HIROTA
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Publication number: 20180354895Abstract: The invention relates to a process for the production of urea ammonium nitrate, a system and a method of modifying a plant. The process comprises subjecting ammonia-containing off-gas resulting from the production of ammonium nitrate (AN off-gas) to condensation under acidic conditions so as to form an acidic condensate, and using at least part of the acidic condensate as an acidic scrubbing liquid in a finishing treatment section having a gas inlet in fluid communication with a gas outlet of a finishing section of a urea production unit, wherein the finishing section is adapted to solidify urea liquid, and wherein said finishing treatment section is adapted to subject ammonia-containing off-gas of the finishing section to treatment with an acidic scrubbing liquid.Type: ApplicationFiled: December 21, 2016Publication date: December 13, 2018Applicant: Stamicarbon B.V.Inventors: Giusy Elisa PUCI, Joey DOBREE
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Publication number: 20180354896Abstract: This invention relates to a method of preparing D-arginine, and more particularly to a method of preparing D-arginine by optically resolving DL-arginine using D-3-bromocamphor-8-sulfonic acid or a salt thereof as an optical resolving agent.Type: ApplicationFiled: September 6, 2016Publication date: December 13, 2018Applicant: AMINOLOGICS CO., LTD.Inventors: Il-Suk Byun, Jung-Ho Lee, Hye-Lim Ga, Won-Sup Kim
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Publication number: 20180354897Abstract: The present invention relates to a process for preparing alkanesulphonic acid by oxidizing an alkyl mercaptan, a dialkyl disulphide and/or a dialkyl polysulphide having three to nine sulphur atoms with an oxidizing agent, wherein additional oxidizing agentis fed into the oxidation if as yet unoxidized alkyl mercaptan and/or unoxidized dialkyl disulphide and/or at least one intermediate from the oxidation of the dialkyl disulphide and/or of the dialkyl polysulphide is present in the reaction output, and a corresponding apparatus for performance of oxidation reactions.Type: ApplicationFiled: November 30, 2016Publication date: December 13, 2018Applicant: Evonik Degussa GmbHInventors: Benjamin FONFE, Nadine DUERR, Harald JAKOB, Chiu Kee CHEUNG, Andreas DOERFLEIN, Sebastian FUSS
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Publication number: 20180354898Abstract: A process for the preparation of 2-alkyl-4-trifluoromethyl-3-alkylsulfonylbenzoic acids of the formula (I) is described. Herein, the substituents are radicals such as alkyl and substituted phenyl.Type: ApplicationFiled: November 28, 2016Publication date: December 13, 2018Inventors: Christoph SCHOTES, Christoph SÄMANN
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Publication number: 20180354899Abstract: A method of purifying dimethyl sulfoxide includes distilling a dimethyl sulfoxide-containing liquid in the presence of sodium carbonate in an inert gas atmosphere to distill out dimethyl sulfoxide, an amount of the sodium carbonate with respect to 100 g of pure dimethyl sulfoxide in a residual liquid after the distillation being 6 times or more the amount of the sodium carbonate with respect to 100 g of the pure dimethyl sulfoxide in the dimethyl sulfoxide-containing liquid before the distillation.Type: ApplicationFiled: November 21, 2016Publication date: December 13, 2018Inventors: Haruo Murano, Katsuhiro Shibayama
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Publication number: 20180354900Abstract: Provided is a composition that is improved in terms of caking of a disulfide compound. Specifically, the present invention provides a composition containing 0.01 parts by mass or more of an anticaking agent per 100 parts by mass of a disulfide compound represented by formula (1) (wherein R1 and R2 each independently represent a hydrogen atom, a C1-20 alkyl group, a hydroxy group, a C1-20 alkoxy group, a substituted or unsubstituted amino group, a nitro group, or a halogen atom).Type: ApplicationFiled: December 6, 2016Publication date: December 13, 2018Applicant: SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Katsumi TAKANO, Takeshi TAKEUCHI, Hiroyuki SHIRAISHI
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Publication number: 20180354901Abstract: In its many embodiments, the present invention provides certain substituted bispiperidinyl compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein ring A, ring B, R1, R2, R3, L, R4, X, Z, Li, Q and R5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.Type: ApplicationFiled: November 29, 2016Publication date: December 13, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Michael T. Rudd, David Jonathan Bennett, Jenny Wai, Zhaoyang Meng
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Publication number: 20180354902Abstract: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.Type: ApplicationFiled: March 5, 2018Publication date: December 13, 2018Inventors: Alberto Ortega Muñoz, Matthew Colin Thor Fyfe, Marc Martinell Pedemonte, Maria de los Angeles Estiarte Martinez, Nuria Valls Vidal, Guido Kurz, Julio Cesar Castro Palomino Laria
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Publication number: 20180354903Abstract: Provided is a compound that can easily introduce a 2-pentafluorosulfanylpyridyl group into a target compound. The compound is represented by General Formula (d): In the formula, k is 1 or 2, R1 is an alkyl group having 1 or 2 carbon atoms, k is an integer of 0 to 4, R2 is a linear or branched alkyl group having 1 to 4 carbon atoms, m is an integer of 0 to 5, and A? is a counter anion.Type: ApplicationFiled: September 15, 2016Publication date: December 13, 2018Inventors: Norio SHIBATA, Kohei MATSUZAKI, Norimichi SAITO
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Publication number: 20180354904Abstract: The present invention describes novel diamino pyridine derivatives exhibiting JAK modulating properties. The present invention also relates to pharmaceutical compositions comprising these novel compounds, methods of using said compounds in the treatment of various diseases and disorders being susceptible to JAK modulation, and processes for preparing the compounds described hereinafter.Type: ApplicationFiled: November 24, 2016Publication date: December 13, 2018Inventor: Gebhard THOMA
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Publication number: 20180354905Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.Type: ApplicationFiled: August 22, 2016Publication date: December 13, 2018Inventors: Todd Brady, Scott Young, William A. Kinney, Susan Macdonald
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Publication number: 20180354906Abstract: Disclosed are compounds of formula I as described herein, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also disclosed are pharmaceutical compositions comprising at least one such compound, and methods involving use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.Type: ApplicationFiled: June 15, 2018Publication date: December 13, 2018Inventors: Pravin L. Kotian, Yarlagadda S. Babu, Minwan Wu, Venkat R. Chintareddy, V. Satish Kumar, Weihe Zhang
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Publication number: 20180354907Abstract: The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CB1 receptor and the CB2 receptor.Type: ApplicationFiled: March 6, 2018Publication date: December 13, 2018Inventors: Robert M. Jones, Sangdon Han, Lars Thoresen, Jae-Kyu Jung, Sonja Strah-Pleynet, Xiuwen Zhu, Yifeng Xiong, Dawei Yue
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Publication number: 20180354908Abstract: Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises formula (I) wherein X1, and X2 may be the same or different and each is independently selected from C, N, O and S; X3, X4, X5, and X6 may be the same or different and each is independently selected from C and N; each bond represented by a dotted line may be present or absent, provided that at least one such bond is present; R1, R2, R3, R4, R5 and R6 may be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of R1, R2, R3, R4, R5 and R6 groups present is such that the respective valencies of X1, X2, X3, X4, X5, and X6 are maintained; and wherein at least one of R5 and R6 comprises a group Y, wherein Y is a group having a formula selected from (II), (III), (IV), (V), (VI), (VII) wherein L may be present or absent, and may be a substituted or unsubType: ApplicationFiled: November 2, 2015Publication date: December 13, 2018Applicant: IOmet Pharma Ltd.Inventors: Phillip M. Cowley, Alan Wise, Susan Davis, Michael Kiczun
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Publication number: 20180354909Abstract: Provided herein are compounds of the formula:(I) wherein: R1, R2, R3, R4, R5, X, A1, A2, A3, and A4 are as defined herein. In some aspects, these compounds may be used to treat cancer and other hyperproliferative disease. In some aspects, compositions, methods of treatment, and methods of synthesis are also provided herein.Type: ApplicationFiled: December 9, 2016Publication date: December 13, 2018Applicant: The Board of Regents of the University of Texas SystemInventors: Jef DE BRABANDER, Luis F. PARADA, S. Kyun LIM, Qiren LIANG, Hua-yu WANG, Yufeng SHI
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Publication number: 20180354910Abstract: Provided herein is a process and intermediates for the preparation of a compound of formula (I): or a pharmaceutically acceptable salt thereof, using cyanamide in the reaction.Type: ApplicationFiled: August 21, 2018Publication date: December 13, 2018Inventors: William R. Cantrell, JR., William E. Bauta
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Publication number: 20180354911Abstract: The disclosure in various embodiments is related to a peptide nucleic acid monomer (VI) and an improved process for preparation of PNA (VI) using nosyl-group containing starting material. The process includes reacting amino acid with a nosyl group. The nosyl protected amino acid is alkylated with 2-(Boc-amino)ethyl bromide to obtain an intermediate. The nosyl group of the obtained intermediate is removed to form a PNA backbone. The PNA backbone upon addition of a modified nucleobase results in the formation of a PNA monomer (VI). The obtained PNA monomer exhibits either chiral or achiral geometric properties.Type: ApplicationFiled: June 8, 2018Publication date: December 13, 2018Inventor: PRASANNA RAMANI
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Publication number: 20180354912Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: ApplicationFiled: June 6, 2018Publication date: December 13, 2018Inventors: Yat Sun Or, Thomas P. Blaisdell, Brian C. Shook, In Jong Kim
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Publication number: 20180354913Abstract: The present disclosure provides a novel heterocyclic compound and an organic light emitting device comprising the same.Type: ApplicationFiled: July 20, 2017Publication date: December 13, 2018Inventors: Min Woo JUNG, Dong Hoon LEE, Jung Oh HUH, Boon Jae JANG, Min Young KANG, Dong Uk HEO, Mi Yeon HAN