Patents Issued in December 20, 2018
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Publication number: 20180362399Abstract: Methods for regenerating poisoned salt bath comprising providing a salt bath comprising at least one of KNO3 and NaNO3, providing an ion-exchangeable substrate comprising lithium cations, contacting at least a portion of the ion-exchangeable substrate with the salt bath, whereby lithium cations in the salt bath diffuse from the ion-exchangeable substrate and are dissolved in the salt bath, and selectively precipitating dissolved lithium cations from the salt bath using phosphate salt. The methods further include preventing or reducing the formation of surface defects in the ion-exchangeable substrate by preventing or reducing the formation of crystals on the surface of the ion-exchangeable substrate upon removal from the salt bath.Type: ApplicationFiled: November 18, 2016Publication date: December 20, 2018Inventors: Jaymin Amin, Xiaoju Guo, Todd LeRoy Heck, Hongmei Hu, Yuhui Jin, Pascale Oram, Ljerka Ukrainczyk
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Publication number: 20180362400Abstract: A sealed article and methods of making the same. The sealed article includes a first and second glass pane. The first and second glass panes include inner surfaces opposite outer surfaces and at least one outer edge. The second glass pane is spaced apart from and positioned substantially parallel to the first glass pane with a low emissivity layer there between. An seal is formed between the first and second glass panes contiguous the low emissivity layer.Type: ApplicationFiled: November 29, 2016Publication date: December 20, 2018Applicant: Corning IncorporatedInventors: Alexander Mikhailovich Streitsov, John Christopher Thomas
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Publication number: 20180362401Abstract: The disclosure discloses a manufacturing method of tempered vacuum glass, comprising the following steps: (1) manufacturing metalized layers, and performing tempering or thermal enhancement on the glass substrates; (2) placing a metal solder on the metalized layers; (3) superposing the glass substrates to form a tempered glass assembly; (4) heating the tempered glass assembly to 60-230° C.; (5) keeping the tempered glass assembly within the heating temperature range of step (4) in a vacuum chamber, and vacuumizing the vacuum chamber to a preset vacuum degree; and (6) hermetically sealing the metalized layers by adopting a metal brazing process.Type: ApplicationFiled: August 16, 2016Publication date: December 20, 2018Applicant: LUOYANG LANDGLASS TECHNOLOGY CO., LTD.Inventor: Yan ZHAO
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Publication number: 20180362402Abstract: Environmentally responsible insulating construction blocks and structures constructed primarily of recycled materials are disclosed. The environmentally friendly construction blocks and structures comprise shredded rubber tire pieces coated with silica fume, slag cement and cement, which are then mixed with water and formed in a mold. A layer of grout or a fireproof material may be disposed on one side of the environmentally responsible insulating construction block. The environmentally responsible insulating construction blocks provide high insulation as well as strength for applications such as green roofing, wall construction and green roofing decks. Environmentally friendly structures can be built by pouring the coated shredded rubber tire pieces into molds to form walls, and then to pour a layer of the coated shredded rubber tire pieces as a roof deck, thereby creating a self-supporting structure in a monolithic pour.Type: ApplicationFiled: August 9, 2018Publication date: December 20, 2018Applicant: The Shredded Tire, Inc.Inventor: Richard P. Spreen
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Publication number: 20180362403Abstract: A variety of systems, methods and compositions are disclosed, including, in one method, providing a foamed cement composition comprising a hydraulic cement, water, a foaming surfactant, a gas, and a nanocellulose foam stabilizing additive; placing the foamed cement composition in a selected location; and allowing the foamed cement composition to set.Type: ApplicationFiled: February 8, 2016Publication date: December 20, 2018Applicant: Halliburton Energy Services, Inc.Inventors: William Cecil Pearl, Jr., Samuel J. Lewis, Jeffery Dwane Karcher
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Publication number: 20180362404Abstract: Conventional methods suffer from unsatisfactory performance of the dehydration-preventing agent at a high temperature, and the present invention provides a cement admixture exhibiting an excellent dehydration-preventing effect at a high temperature. The cement admixture of the present invention includes a crosslinked product of a modified polyvinyl alcohol-based resin, wherein the dissolution rate of 1 g of the crosslinked product of a modified polyvinyl alcohol-based resin for 1 liter of water at 70° C. is 50% or less.Type: ApplicationFiled: December 6, 2016Publication date: December 20, 2018Applicant: THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD.Inventors: Takahiro SAKA, Chizuko FURO, Shusaku MANDAI
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Publication number: 20180362405Abstract: An object is to establish a technique for producing a resin composite material at low cost. A resin composition contains cellulose fibers, a fibrillation aid, and a resin.Type: ApplicationFiled: December 1, 2016Publication date: December 20, 2018Applicants: Kyoto University, DIC CorporationInventors: Yoshinobu Tsujii, Keita Sakakibara, Tetsuya Harada, Takahito Ikuma, Junya Okawa, Ikko Matsusue, Junji Shinya
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Publication number: 20180362406Abstract: The present invention relates to a dry refractory particulate composition comprising a zeolithic microstructure, to a green body and to a refractory lining formed therefrom, and to uses thereof.Type: ApplicationFiled: December 15, 2016Publication date: December 20, 2018Inventors: Pierre MEUNIER, Nicolas DUVAUCHELLE, Serge MARTIN-CALLE, Jérome SOUDIER, Romain TECHER
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Publication number: 20180362407Abstract: Cementitious binder compositions for cementitious products including a hydraulic cement-based reactive powder blend, an inorganic flow control agent, and a metal-based dimensional movement stabilizing agent including at least one member of the group of lithium salt and lithium base, and methods for making the cementitious binder compositions.Type: ApplicationFiled: August 23, 2018Publication date: December 20, 2018Applicant: UNITED STATES GYPSUM COMPANYInventors: Paul White, Ashish Dubey
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Publication number: 20180362408Abstract: The present invention relates to a compound for making high-temperature-resistant or refractory molded bodies, made up of a mixture of: a refractory or high-temperature-resistant inorganic powder, granules and/or granulate, including a free-flowing compound or a powder made of carbon or also without carbon, a binder, the binder being made of a combination of tannin, lactose, fine-grained silica and aluminum powder, as well as the binder itself, and molded bodies produced from the compound including the binder, and a method of making same.Type: ApplicationFiled: July 29, 2016Publication date: December 20, 2018Inventors: Ewan GUEGUEN, Christos G. ANEZIRIS, Christiane BIERMANN, Antoine DUCASTEL
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Publication number: 20180362409Abstract: A ceramic sintered body containing aluminum oxide, tungsten carbide and zirconium oxide, wherein: the zirconium oxide contains ZrO and ZrO2; the ZrO2 has a crystal structure or structures of one or two kinds selected from the group consisting of a tetragonal crystal structure and a cubic crystal structure; and when, in X-ray diffraction, regarding a peak intensity for a (111) plane of the ZrO as being denoted by I1, regarding a peak intensity for a (101) plane of ZrO2 having a tetragonal crystal structure as being denoted by I2t, and also regarding a peak intensity for a (111) plane of ZrO2 having a cubic crystal structure as being denoted by I2c, a ratio of I1 based on a total of I1, I2t and I2c [I1/(I1+I2t+I2c)] is from 0.05 or more to 0.90 or less.Type: ApplicationFiled: November 25, 2016Publication date: December 20, 2018Applicant: TUNGALOY CORPORATIONInventor: Takashi WATANABE
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Publication number: 20180362410Abstract: A ceramic material for a multilayer ceramic capacitor has a capacitance variation from ?17 percent to +15 percent at a temperature ranging from ?55° C. to 200° C., and has a dielectric loss less than 1% at a temperature ranging from 90° C. to 200° C. The ceramic material includes a base component consisting of a barium titanate and a sodium bismuth titanate, and a manganese dopant in an amount not greater than 0.05 mole percent based on total moles of the base component.Type: ApplicationFiled: September 8, 2017Publication date: December 20, 2018Inventors: Sea-Fue WANG, Yi-Xin LIU, Yen-Sheng CHEN
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Publication number: 20180362411Abstract: A structure includes a polycrystalline substance of yttrium fluoride, wherein an average crystallite size in the polycrystalline substance is less than 100 nanometers. When taking a peak intensity detected near diffraction angle 2?=24.3° by X-ray diffraction as ?, and taking a peak intensity detected near diffraction angle 2?=25.7° as ?, a peak intensity ratio ?/? of the structure is not less than 0% and less than 100%.Type: ApplicationFiled: August 24, 2018Publication date: December 20, 2018Inventors: Hiroaki ASHIZAWA, Masakatsu KIYOHARA
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Publication number: 20180362412Abstract: The present invention relates to a method for making a three dimensional carbon structure and also to a sintered article comprising pyrolysed carbon particles. The method comprises sintering a powdered organic material, preferably using selective laser sintering, to form a sintered three dimensional structure having a desired shape. The sintered structure is then pyrolysed to form the final carbon structure. The method is particularly useful in the production of biomedical implants such as bone scaffolds and joint replacements. In some embodiments, the powdered organic material is lignin which provides a renewable and highly cost effective starting material for the method of the present invention.Type: ApplicationFiled: July 10, 2018Publication date: December 20, 2018Applicant: MORRIS BROTHERS AND COMPANY HOLDINGS LIMITEDInventor: Patrick John Morris
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Publication number: 20180362413Abstract: Methods for preparing ceramic matrix composites using melt infiltration and chemical vapor infiltration are provided as well as the resulting ceramic matrix composites. The methods and products include the incorporation of sacrificial fibers to provide improved infiltration of the fluid infiltrant. The sacrificial fibers are removed, such as decomposed during pyrolysis, resulting in the formation of regular and elongate channels throughout the ceramic matrix composite. Infiltration of the fluid infiltrant can then take place using the elongate channels resulting in improved density and an improved ceramic matrix composite product.Type: ApplicationFiled: June 14, 2017Publication date: December 20, 2018Inventors: David Bruce Hall, James Joseph Murray, Jason Robert Parolini, Michael Alan Vallance, Juan Borja, Daniel George Norton, Jared Hogg Weaver, Daniel Gene Dunn
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Publication number: 20180362414Abstract: A fertilizer derived from an organic source and a method of making are provided. The fertilizer of the present invention advantageously has a Nitrogen content greater than 4%. The method of making the fertilizer also produces potable water.Type: ApplicationFiled: June 27, 2018Publication date: December 20, 2018Inventor: Denise Crabtree
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Publication number: 20180362415Abstract: An engineered composite system designed to be passive or inert under one set of conditions, but becomes active when exposed to a second set of conditions. This system can include a dissolving or disintegrating core, and a surface coating that has higher strength or which only dissolves under certain temperature and pH conditions, or in selected fluids. These reactive materials are useful for oil and gas completions and well stimulation processes, enhanced oil and gas recovery operations, as well as in defensive and mining applications requiring high energy density and good mechanical properties, but which can be stored and used for long periods of time without degradation.Type: ApplicationFiled: August 23, 2018Publication date: December 20, 2018Inventors: Brian Doud, Andrew Sherman, Nicholas Farkas, Brian Werry
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Publication number: 20180362416Abstract: The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula: X-L-M-Re wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a mass spectrometer, M is a mass modifier, and Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte, wherein each mass label in the set has an integer mass, wherein each mass label in the set has the same integer mass, and wherein the set comprises two or more subsets of mass labels, each subset comprising one, two or more mass labels, and wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets, and wherein each mass label is distinguishable by mass spectrometry.Type: ApplicationFiled: December 9, 2016Publication date: December 20, 2018Applicant: ELECTROPHORETICS LIMITEDInventor: ANDREW HUGIN THOMPSON
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Publication number: 20180362417Abstract: The present disclosure provides a process for effectively separating and removing by-products (light gas, C5-C6 hydrocarbon oil fraction, polyethylbenzene) contained in a substantial amount in addition to ethylbenzene as a target compound in an alkylation reaction product of a fluidized catalytic cracking off-gas to prepare ethylbenzene having high purity, and process economical efficiency may be secured by utilizing the polyethylbenzene as an absorbent or gasoline fraction, without requiring a transalkylation reaction for further producing ethylbenzene from polyethylbenzene.Type: ApplicationFiled: June 4, 2018Publication date: December 20, 2018Inventors: Dae Sung Song, Hee Du Lee, Sang Il Lee, Kyung Jong Oh, Ji Hoon Lee, Yeon Ho Kim
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Publication number: 20180362418Abstract: Methods and catalysts for producing ethylene and methanol from natural gas are presented. Methods include integration of oxidative conversion of methane to ethane, ethane in situ thermal cracking using the thermal heat generated thereby and direct hydrogenation of byproducts to methanol or oxidative CO2 autothermal reforming of methane to syngas.Type: ApplicationFiled: December 7, 2016Publication date: December 20, 2018Applicant: SABIC Global Technologies B.V.Inventors: Aghaddin MAMEDOV, David WEST, Wugeng LIANG, Sagar SARSANI
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Publication number: 20180362419Abstract: Methods for producing butadiene by the oxidative dehydrogenation of butene are provided. Methods for producing butadiene from a feed stream including oxygen and butene in a molar ratio of oxygen to butene (O2/C4H8) from about 0.9 to about 1.5 can include introducing the feed stream to a catalyst in the presence of steam. The molar ratio of steam to butene (H2O/C4H8) can be from about 10 to about 20. Methods can further include reacting the butene to generate a product stream therefrom comprising butadiene and water. Methods can further include separating water from the product stream to generate a butadiene stream including greater than about 85 wt-% butadiene.Type: ApplicationFiled: January 5, 2017Publication date: December 20, 2018Inventors: Xin LI, Jorge JIMENEZ, Paulette HAZIN, Reggie TENNYSON, Xiankuan ZHANG
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Publication number: 20180362420Abstract: Disclosed are methods of preparing unsaturated carbocyclic compounds through dehydrogenation of corresponding saturated carbocyclic compounds.Type: ApplicationFiled: December 15, 2017Publication date: December 20, 2018Inventors: Sunitha Rao TADEPALLI, Alan Stuart GOLDMAN, Xiaoguang ZHOU, Geatesh Karunakaran TAMPY, John CHERKAUSKAS
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Publication number: 20180362421Abstract: Disclosed is a process for the preparation of cis-1,1,1,4,4,4-hexafluoro-2-butene comprising contacting 1,1,1-trifluorotrichloroethane with hydrogen in the presence of a catalyst comprising ruthenium to produce a product mixture comprising 1316mxx, recovering said 1316mxx as a mixture of Z- and E-isomers, contacting said 1316mxx with hydrogen, in the presence of a catalyst selected from the group consisting of copper on carbon, nickel on carbon, copper and nickel on carbon and copper and palladium on carbon, to produce a second product mixture, comprising E- or Z-CFC-1326mxz, and subjecting said second product mixture to a separation step to provide E- or Z-1326mxz.Type: ApplicationFiled: August 23, 2018Publication date: December 20, 2018Inventors: IVAN SERGEYEVICH BALDYCHEV, STEPHAN M. BRANDSTADTER, PATRICIA CHEUNG, MARIO JOSEPH NAPPA
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Publication number: 20180362422Abstract: The present disclosure provides, in part, a solvent composition for use as a replacement for slow evaporating solvents. The solvent composition may include para-Chlorobenzotrifluoride (PCBTF), a methylated organosilicon compound, and a carbonate ester.Type: ApplicationFiled: June 2, 2016Publication date: December 20, 2018Inventors: David Anthony Pasin, Shira Devorah Bogner
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Publication number: 20180362423Abstract: It is disclosed a process to produce a bio-product starting from a ligno-cellulosic feedstock, comprising a pre-hydrolysis step of the ligno-cellulosic feedstock in one or more pre-hydrolysis vessels to produce a liquid pre-hydrolyzate comprising water and water soluble hemicellulose, followed by a multi-step hydrolysis of the water soluble hemicellulose. The hydrolysis steps are conducted in separated vessel. The liquid pre-hydrolyzate is subjected to a partial hydrolysis step in a first hydrolysis vessel, to produce a first hydrolyzate. A portion of the first hydrolyzate, comprising remnant water soluble hemicellulose, is recirculated in at least one pre-hydrolysis vessel and subjected to a second hydrolysis step. Another portion of the first hydrolyzate comprising monomeric sugars is removed and converted to the bio-product, preferably after a refining hydrolysis step. The process also produces a hemicellulose-depleted feedstock which is preferably treated to produce a cellulosic pulp.Type: ApplicationFiled: December 1, 2016Publication date: December 20, 2018Applicant: VALMET AKTIEBOLAGInventors: Patrizia FERRANDO, Marco BERNARDI, Dario GIORDANO, Lari LAMMI, Mats NORDGREN
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Publication number: 20180362424Abstract: The invention provides a continuous process for the preparation of ethylene glycol and 1, 2-propylene glycol from starting material comprising one or more saccharides, said process being carried out in a reactor system comprising a reactor vessel equipped with an external recycle loop and said process comprising the steps of: i) providing the starting material in a solvent, via an inlet, to the external recycle loop and contacting it therein with a retro-aldol catalyst composition to provide an intermediate stream; ii) then contacting said intermediate stream with hydrogen in the presence of a hydrogenation catalyst composition in the reactor vessel; iii) withdrawing a product stream comprising glycols from the reactor vessel; iv) providing a portion of said product stream, via an outlet, for separation and purification of the glycols contained therein; and v) recycling the remainder of said product stream via the external recycle loop.Type: ApplicationFiled: December 7, 2016Publication date: December 20, 2018Inventors: Leslie Andrew CHEWTER, Jean Paul Andre Marie Joseph Ghislain LANGE, Duraisamy MUTHUSAMY, Timothy Michael NISBET, Evert VAN DER HEIDE, Pieter HUIZENGA
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Publication number: 20180362425Abstract: The invention provides a continuous process for the preparation of ethylene glycol and 1,2-propylene glycol from starting material comprising one or more saccharides, said process comprising providing a feedstock comprising said one or more saccharides in a solvent to a reactor, said reactor having supported therein a heterogeneous hydrogenation catalytic composition and contacting the feedstock therein directly with said heterogeneous hydrogenation catalytic composition and concurrently with a retro-aldol catalyst composition in the presence of hydrogen, wherein said reactor operates in an essentially plug flow manner.Type: ApplicationFiled: December 7, 2016Publication date: December 20, 2018Applicant: SHELL OIL COMPANYInventors: Evert VAN DER HEIDE, Timothy Michael NISBET, Leslie Andrew CHEWTER, Pieter HUIZENGA
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Publication number: 20180362426Abstract: Catalysts and methods for the selective conversion of carbon dioxide and hydrogen into methanol using heat and high pressure in a hydrogenation reactor are disclosed. Key to this process are catalysts, which are comprised of multimetallic, aluminum oxide-supported nanoparticles. In some embodiments of the invention, the catalytic nanoparticles are made from mixtures of zinc and copper, or mixtures of palladium and copper, in different stoichiometric equivalents. In others, stoichiometric additives or dopants are added in order to improve the rate of product formation, improve selectivity, or allow for flow configurations. Methods for the use of these catalysts for the synthesis of methanol, and for the purification of CO2, H2, or CO gas streams by transforming contaminants into liquid methanol are also described.Type: ApplicationFiled: June 19, 2018Publication date: December 20, 2018Applicant: Catalytic Innovations, IncInventors: Chi Chen, Juliet Khosrowabadi Kotyk, Stafford Wheeler Sheehan
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Publication number: 20180362427Abstract: Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent. Also described are methods of making these new crystalline polymorphic forms as well as methods of using these polymorphic forms to treat cancer.Type: ApplicationFiled: June 15, 2016Publication date: December 20, 2018Applicant: Targent, LLCInventors: Stefano Luca Giaffreda, Elena Dichiarante
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Publication number: 20180362428Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.Type: ApplicationFiled: December 14, 2016Publication date: December 20, 2018Inventors: Igor BENDIK, Piero GEOTTI-BIANCHINI, Marc HEIDL, Eileen JACKSON, Alexander SCHLIFKE-POSCHALKO
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Publication number: 20180362429Abstract: A method of extracting cannabidiol from hemp.Type: ApplicationFiled: January 21, 2017Publication date: December 20, 2018Applicant: Yunnan Hansu bio-technology Co., LtdInventors: Ke ZHANG, Xin TAN, Weibo GAO, Tanran CHANG
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Publication number: 20180362430Abstract: A phenylene ether oligomer is prepared by a process that includes partially converting 2,6-dimethylphenol to 3,3?,5,5?-tetramethyl-4,4?-dihydroxybiphenyl and/or 3,3?,5,5?-tetramethyldiphenoquinone, converting the residual 2,6 dimethylphenol to poly(2,6-dimethyl-1,4-phenylene ether) and any 3,3?,5,5?-tetramethyl-4,4?-dihydroxybiphenyl to 3,3?,5,5?-tetramethyldiphenoquinone, and reacting the poly(2,6-dimethyl-1,4-phenylene ether) and 3,3?,5,5?-tetramethyldiphenoquinone to form the phenylene ether oligomer. The preparation can be conducted without isolation of intermediates.Type: ApplicationFiled: November 10, 2016Publication date: December 20, 2018Applicant: SABIC Global TechnologiesInventors: Rajesh CHOWDHURY, Eylem TARKIN-TAS, Xuezhi JIN
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Publication number: 20180362431Abstract: An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are inexpensive and the reactions are commercially feasible and amenable to scaling up. The principal starting material, (?)-?-Pinene, is on the GRAS list (generally recognized as safe).Type: ApplicationFiled: December 8, 2016Publication date: December 20, 2018Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventor: Roger Laine
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Publication number: 20180362432Abstract: Methods of C—H bond fluorination using non-heme manganese catalyst are described herein. For example, a method comprises providing a reaction mixture including a non-heme manganese catalyst, a substrate comprising an sp3 C—H bond and a fluorinating agent and converting the sp3 C—H bond to a C—F bond in the presence of the non-heme manganese catalyst or a derivative thereof.Type: ApplicationFiled: December 14, 2016Publication date: December 20, 2018Inventors: John T. GROVES, Xinyi CHEN
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Publication number: 20180362433Abstract: Novel CUR- and CUR-BF2 compounds exhibiting anti-tumor properties are presented. CUR compounds bearing fluorinated moieties with selective fluorine introduction into the ?-carbonyl moiety as well as CUR-BF2 adducts and CURs with diverse substitution patterns in the phenyl rings including fluorinated substituents (SCF3, OCF3, and F) and/or bulky activating groups (OMe, OAc, and OBz) are presented. Fluorinated aryl-pyrazoles and isoxazoles as well as novel CUR and CUR-BF2 compounds with monocyclic aromatic and bicyclic-heteroaromatic lateral rings, bearing fluorine(s), OCF3, CF3, and SCF3 groups, and their alpha-carbonyl-fluorinated analogs, as well as their pyrazole and isoxazole derivatives are presented. The CUR-pyrazoles embody analogs that are fluorinated at the phenyl-pyrazole moiety. The compounds and their derivatives exhibited exceptional cytotoxic and anti-proliferative activity against several cancer cell-lines. Deuterated CUR-BF2 and CUR compounds were also synthesized.Type: ApplicationFiled: June 18, 2018Publication date: December 20, 2018Applicant: University of North Florida Board of TrusteesInventor: Kenneth K. Laali
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Publication number: 20180362434Abstract: This disclosure provides for routes of synthesis of ?,?-unsaturated carboxylic acids and their salts, including acrylic acid. For example, disclosed is a process for producing an ?,?-unsaturated carboxylic acid or its salt, comprising: (1) contacting a group 8-11 transition metal precursor, an olefin, carbon dioxide, a diluent, and a sulfur oxoacid anion-substituted polyaromatic resin or a phosphorus oxoacid anion-substituted polyaromatic resin with associated metal cations to provide a mixture; and (2) applying reaction conditions to the mixture suitable to produce the ?,?-unsaturated carboxylic acid or a salt thereof. Methods of regenerating the polyaromatic resin with associated metal cations are described.Type: ApplicationFiled: June 6, 2018Publication date: December 20, 2018Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Pasquale Iacono, Mark L. Hlavinka
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Publication number: 20180362435Abstract: This disclosure provides for synthetic routes of acrylic acid and other ?,?-unsaturated carboxylic acids and their salts, including catalytic methods. For example, there is provided a process for producing an ?,?-unsaturated carboxylic acid or its salt, comprising: (1) contacting in any order, a group 8-11 transition metal precursor, an olefin, carbon dioxide, a diluent, and a porous crosslinked polyphenoxide resin comprising associated metal cations to provide a mixture; and (2) applying reaction conditions to the mixture suitable to produce the ?,?-unsaturated carboxylic acid or a salt thereof. Methods of regenerating the polyphenoxide resin comprising associated metal cations are described.Type: ApplicationFiled: June 6, 2018Publication date: December 20, 2018Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Pasquale Iacono, Mark L. Hlavinka
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Publication number: 20180362436Abstract: Disclosed is a continuous process for producing ?,?-unsaturated carboxylic acids or salts thereof, comprising: 1) in a first stage, contacting (a) a transition metal precursor compound comprising at least one first ligand, (b) optionally, at least one second ligand, (c) an olefin, (d) carbon dioxide (CO2), and (e) a diluent to form a first composition; 2) in a second stage, contacting a polyanionic solid with the first composition to form a second composition; and 3) in a third stage, (a) contacting the second composition with a polar solvent to release a metal salt of an ?,?-unsaturated carboxylic acid and form a reacted solid. Methods of regenerating the polyanionic solid are described.Type: ApplicationFiled: June 6, 2018Publication date: December 20, 2018Applicant: CHEVRON PHILLIPS CHEMICAL COMPANY LPInventors: Mark L. Hlavinka, Gregory G. Hendrickson, Pasquale Iacono
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Publication number: 20180362437Abstract: This disclosure relates to a method for continuous recovery of (meth)acrylic acid and an apparatus used for the recovery method. The method of continuous recovery of (meth)acrylic acid according to the present invention may minimize loss of (meth)acrylic acid particularly in the distillation process, and yet enables stable operation of the distillation process and energy reduction.Type: ApplicationFiled: June 28, 2018Publication date: December 20, 2018Inventors: Jong Hun SONG, Se Won BAEK, Sul Hee YOO, Yoon Jae MIN
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Publication number: 20180362438Abstract: A novel highly stable sodium diacetate crystal, in which the volatilization of acetic acid can be suppressed for a long period. More specifically, a sodium diacetate crystal having a median diameter in the range of 300 to 3000 ?m.Type: ApplicationFiled: October 9, 2017Publication date: December 20, 2018Inventors: Hideo SHIMAMURA, Tadataka MURAKAMI, Yasunori KURATA, Ayaka KATO
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Publication number: 20180362439Abstract: The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.Type: ApplicationFiled: August 26, 2018Publication date: December 20, 2018Applicant: SUNSHINE LAKE PHARMA CO., LTD.Inventors: Lei CHEN, Guodong SUN, Xiaodong HAN, Shun LI, Jiebin ZENG, Zhongqing WANG, Zhonghua LUO
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Publication number: 20180362440Abstract: A method for enhancing reaction efficiency of a terephthalate plasticizer involves using a homogenizer to fine PTA to slurry having a particle size of 80-110 ?m, and esterifying the PTA slurry with a C6-C10 alcohol in the presence of a titanium-based catalyst. The reactivity is enhanced by more than 37.5%, and the terephthalate plasticizer so synthetized is low-odor and has a purity of more than 99.5% as well as good physical properties such as acid value, color, and index of refraction.Type: ApplicationFiled: June 14, 2018Publication date: December 20, 2018Inventors: Te-Chao LIAO, Jung-Jen CHUANG, Hsun-Min LIN
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Publication number: 20180362441Abstract: The present invention provides compounds of formula (I): wherein W is independently selected from the group consisting of H, F, Cl, Br and I; 10 X is independently selected from the group consisting of H, F, Cl, Br, I, CW3 and OR on the basis that at least one X is OR; R is independently selected from the group consisting of C(O) (CH2 )m(CF2 )nY and CW2C(CW2OC(O)(CH2 )m(CF2 )nY)3; m is an integer from 0 to 2; 15 n is an integer from 2 to 8; Y is C(Z)3; and Z is independently selected from the group consisting of H, F, Cl, Br and I. Such compounds may be utilised as lubricants, for example in heat transfer compositions.Type: ApplicationFiled: December 7, 2016Publication date: December 20, 2018Inventors: Robert Elliot Low, Andrew Paul SHARRATT, Emma Jane HODGSON
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Publication number: 20180362442Abstract: The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in particular for removing contaminants from nitrated crude nitric acid esters, which nitrated crude nitric acid esters arise during the nitration of monovalent or multivalent aliphatic or alicyclic alcohols capable of nitration, after the separation of the final nitrating acid, and to a production system for nitrating monovalent or multivalent aliphatic alcohols capable of nitration with subsequent purification of the nitrated nitric acid esters.Type: ApplicationFiled: March 20, 2018Publication date: December 20, 2018Applicant: Josef Meissner GmbH & Co. KGInventors: Jürgen Pöhlmann, Heinrich Hermann, Mïrko Händel, Jürgen Gebauer
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Publication number: 20180362443Abstract: Provided herein are methods of treating cancer comprising administering antibodies and antigen-binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms, and dosing regimens for related monotherapies and combination therapies.Type: ApplicationFiled: August 24, 2018Publication date: December 20, 2018Applicant: Celldex Therapeutics, Inc.Inventors: Theresa Marie LAVALLEE, Carolyn Fowler SIDOR, Diego ALVARADO
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Publication number: 20180362444Abstract: An improved and well reproducible process for the preparation of Enclomiphene citrate having needle shaped crystal habit is provided. It is also related to a solid form of Enclomiphene citrate.Type: ApplicationFiled: April 22, 2016Publication date: December 20, 2018Inventors: Lorenzo CARUANA, Pierluigi PADOVAN, Claudio DAL SANTO
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Publication number: 20180362445Abstract: The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds or their derivatives to the L-DOPA carboxyl group. The synthesis allows to produce L-DOPA derivatives which are highly soluble in water as well as aqueous and biocompatible liquids and have an improved hydrolytic stability in water or aqueous and biocompatible media for an application over several days. The invention helps producing L-DOPA substances for applications in the fields of medicine, biology and medical engineering as well as in the pharmaceutical industry.Type: ApplicationFiled: March 30, 2016Publication date: December 20, 2018Inventors: Johannes TACK, Ralf WYRWA, Thorsten LAUBE, Matthias SCHNALBELRAUCH, Juergen WEISSER, Christoph VOELKEL
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Publication number: 20180362446Abstract: The present invention relates to a novel process for preparing substituted biphenylamides of the general formula (V) characterized in that anilides of the formula (II) in a solvent other than tetrahydrofuran, are reacted with an organoboron compound of the formula (III) in the presence of a catalyst system consisting of a ruthenium catalyst, an activator, an oxidizing agent and a metal triflate.Type: ApplicationFiled: August 27, 2018Publication date: December 20, 2018Inventors: Thomas HIMMLER, Lars RODEFELD, Jonathan HUBRICH, Lutz ACKERMANN
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Publication number: 20180362447Abstract: Provided is a method of producing an aromatic amide derivative represented by Formula (I), which method includes a process a containing reacting an aniline derivative represented by Formula (II) with a carboxylic acid derivative represented by Formula (III) in the presence of a base to obtain an imide compound represented by Formula (IV) and a process b containing hydrolyzing the imide compound represented by Formula (IV) to obtain the aromatic amide derivative represented by Formula (I): wherein R1 represents a C1-C4 haloalkyl group, etc.; each of R2 and R3 independently represents a hydrogen atom, a halogen atom, etc.; R4 represents a hydrogen atom, a C1-C4 alkyl group, etc.; each of X1 and X2 independently represents a halogen atom, a C1-C4 haloalkyl group, etc.; and Q represents a C1-C4 alkyl group, a phenyl group, a pyridyl group, etc.Type: ApplicationFiled: December 16, 2016Publication date: December 20, 2018Applicant: Mitsui Chemicals Agro, Inc.Inventors: Yusuke TAKAHASHI, Hideaki IKISHIMA, Hironari OKURA
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Publication number: 20180362448Abstract: The present invention relates to a novel phenolic acid derivative compound with whitening and antioxidant activities and use thereof. The phenolic acid derivative compound is a compound represented by Formula 1, which is described in the specification, an isomer thereof or a salt thereof. The compound of the present invention has skin whitening activity to inhibit tyrosinase, thus being suitable for use in a pharmaceutical composition or cosmetic product for skin whitening. In addition, the compound of the present invention is suitable for the prevention or treatment of oxidation-derived skin abnormality or disease such as skin aging due to its antioxidant activity.Type: ApplicationFiled: December 9, 2016Publication date: December 20, 2018Inventors: Jin Oh PARK, Ji Won LEE, Jae Young LEE, Hye Ja LEE, Bo kyung KWON