Abstract: An instrument including an actuation gear mechanism that provides two functions of a tool. The actuation gear mechanism comprises a cam mechanism and a gear segment mechanism. The circumference of the cam disk of the cam mechanism—in a first section (?1)—is a spiral curve for generating a stroke for closing the forceps tool, while the circumference of the cam disk—in a second, adjoining, angular range (?2)—is circular. When the cam disk with the circular curved line biases the spring means, no further movement takes place on the output of the cam mechanism. Preferably, two congruent cam disks are provided, whereby these—together with the driving gear and the segment gear, as well as the shaft—form a one-piece plastic injection-molded part. The installation space between the cam disks can be utilized for a slide with a gear rack for shifting the knife.

Abstract: A medical device for the selective mechanical and/or electrosurgical removal of hard and soft tissue in a patient includes an electrically conductive elongated outer housing having a distal opening and an elongated ceramic sleeve. A distal cutting window is formed in the ceramic sleeve, and the distal cutting window is aligned within the distal opening of the outer housing. A metal cutting member is rotatably disposed within the elongated ceramic sleeve and has a cutting element disposed to rotate or rotationally oscillate within the cutting window of the ceramic sleeve. The metal cutting element and the cutting window are configured to shear bone as the cutting element is advanced past an edge of the cutting window with and without the simultaneous delivery of an RF cutting current to the cutting element.

Abstract: Provided is an assembly for dissecting a tissue including a tissue dissector and a bending device. The tissue dissector includes an outer tube inserted into the human body; an inner tube inserted into the outer tube so that a front end protrudes from a front end of the outer tube; a cutting head located at the front end of the inner tube; a cable connected to a rear end of the cutting head; a driving shaft connected to a rear end of the cable; and a drive motor for applying a rotational force to the driving shaft.

Abstract: A surgical instrument for cutting tissue includes a sleeve, a shaft slidably disposed within the sleeve and defining a longitudinal axis, and a plurality of legs coupled to the shaft and disposed about the longitudinal axis. Each leg has a blade attached to an end portion thereof and each blade defines a cutting edge. The shaft is slidable relative to the sleeve between a collapsed configuration, wherein the legs are disposed within the sleeve, and an expanded configuration, wherein the legs extend distally and radially outwardly from the sleeve. In the expanded configuration, the cutting edge of each blade is disposed in a proximally-facing orientation. Alternatively, the shaft is rotatable relative to the sleeve to rotate the legs about the longitudinal axis, thereby rotating each blade through a circular cutting path defining a different diameter. Methods of cutting tissue are also provided.

Abstract: An arthroscopic device is used with a hand piece having a motor drive with a rotating drive shaft. An elongate probe extending along a longitudinal axis and includes a proximal hub on a proximal end. The proximal hub detachably couples to the hand piece, and an openable-closeable jaw structure is disposed on a distal end of the elongate probe. A conversion mechanism carried by the hub converts a rotational motion of the motor drive shaft to a longitudinal motion of an actuator member. The actuator member drives the jaw structure between jaw-open and jaw-closed positions to resect bone and other hard tissues.

Abstract: In one aspect, the present disclosure relates to a method for harvesting biological tissue.

Abstract: A variety of methods for managing a re-usable ultrasonic medical device may include a medical device control module capable of receiving functional data from a user assembled or reassembled ultrasonic medical device, and notifying the user if a value of the functional data lies within an acceptance range. If the value of the functional data does not lie within the acceptance range, the control module may prompt a user to reassemble the device or to clean or replace one or more components thereof. The functional data may relate to a clamp force of a jaw assembly, an impedance or resonant frequency value of an ultrasonic blade, or a mechanical displacement value of one or more moving components of the device.

Abstract: An ultrasonic surgical drill or drill bit includes a tubular member having a longitudinal axis of symmetry and a plurality of fins extending in longitudinal planes each containing the axis. In a surgical method utilizing the drill bit, one places a distal tip of the drill bit in contact with bone, presses the drill bit against the bone, and during that pressing of the drill bit, conducts ultrasonic vibrations into the drill bit. With the fins in contact with the bone, the drill bit is oscillated or angularly reciprocated about a longitudinal axis, so that the fins fragment bone material located between the fins.

Abstract: An instrument includes an ultrasonic blade, a first fluid port, an irrigation member, a second fluid port, and a fluid communication assembly. The ultrasonic blade defines a distal opening. The ultrasonic blade is operable in a first mode to emulsify tissue that is distally positioned relative to the ultrasonic blade. The ultrasonic blade is further operable in a second mode to transect and seal tissue that is transversely positioned relative to the ultrasonic blade. The first fluid port is in communication with the distal opening of the ultrasonic blade. The irrigation member is positioned adjacent to the distal end of the ultrasonic blade. The second fluid port is in communication with the irrigation member. The fluid communication assembly is configured to couple the first fluid port with a fluid source, couple the first fluid port with a suction source, and couple the second fluid port with the fluid source.

Abstract: An ultrasonic surgical instrument includes a body, a shaft, an ultrasonic transducer, a waveguide, and an end effector coupled to a distal end of the shaft. A rotation knob is rotatably coupled to the body and is configured to rotate the shaft, the waveguide, and the end effector together relative to the body. A torque transfer structure is positioned radially outwardly of and in direct contact with the waveguide at an acoustic node thereof. The torque transfer structure is rotationally fixed relative to the waveguide and is configured to rotationally couple the waveguide with the shaft and the rotation knob. The waveguide includes a first axial constraining feature defining a distally facing surface, and the torque transfer structure includes a second axial constraining feature defining a proximally facing surface configured to abut the distally facing surface to constrain the waveguide axially relative to the torque transfer structure and the body.

Abstract: An ultrasonic surgical instrument includes a body, an ultrasonic transducer rotatably supported within the body and having a threaded distal end, a shaft extending from the body, a waveguide extending through the shaft and having a threaded proximal end configured to threadedly engage the threaded distal end to define a threaded coupling, and an end effector at a distal end of the shaft. An integrated torque wrench mechanism is arranged within the body and includes a first torque wrench member rotationally coupled with a proximal end of the transducer, and a second torque wrench member arranged proximally of the first torque wrench member. The torque wrench members are configured to selectively couple together and frictionally engage one another to facilitate application of a predetermined maximum torque to the threaded coupling. The torque wrench members are configured to automatically decouple upon application of the predetermined maximum torque to the threaded coupling.

Abstract: An ultrasound medical device includes: a treatment portion configured to treat a living tissue; and a piezoelectric transducer unit provided in the treatment portion and formed by laminating a plurality of piezoelectric elements, which is configured to excite ultrasound vibration, and a plurality of insulating layers and bonding each of the piezoelectric elements and the insulating layers through bonding layers. A thickness of each of the piezoelectric elements, the insulating layers, and a plurality of the bonding layers is set such that nodes of the ultrasound vibration are located other than in the bonding layers.

Abstract: Disclosed herein are devices and methods for removing tissue. In one aspect, a device for removing tissue includes a hollow elongate member having an outer wall and a lumen, a selectively deployable tissue-cutting element extending from the hollow elongate member, and an actuation member extending through the lumen and coupled to the hollow elongate member at a location that is distal to the tissue-cutting element. Movement of the actuation member can cause the tissue-cutting element to move from the insertion configuration where the tissue-cutting element is not deployed to a tissue-cutting configuration where the tissue-cutting element is deployed such that it is radially extended relative to the insertion configuration.

Abstract: A capturing unit provided on a distal end of a second tube can be deformed into a contracted state and an expanded state, in which the capturing unit is deployed to form a capturing chamber. The capturing chamber has an opening area decreased as it goes from a distal end opening of the capturing chamber toward a proximal end opening of the capturing chamber. A third tube rotatable relative to the second tube and a cutting unit provided on a distal end of the third tube for cutting a foreign substance are arranged in a second lumen. In the expanded state of the capturing unit, the cutting unit is arranged more toward the proximal end opening of the capturing chamber than the distal end opening.

Abstract: The application discloses a set of surgical instruments that may be used to access a human or animal body cavity for medical purposes without causing damage to internal tissues or organs therein, and methods of using the same. The instruments include a safety needle and flexible sheath that may be coupled together and used to establish a minimally invasive method to access a targeted body cavity while preventing or reducing damage to organs or tissues within the targeted cavity. Additional instruments are included within the invention that may be used to establish an access port in the wall of the targeted cavity. That port may be used to introduce catheters or other instruments into the body cavity. It may also be used as a drainage tube for draining or injecting gases and/or fluids from or into the targeted cavity.

Abstract: The present invention presents a medical instrument for penetrating cutaneous and sub-cutaneous tissue, causing less hemorrhage and patient pain. This medical device for insertion into tissue comprising one or more section, said section including a plurality of facets; and each facet is configured to deflect the tissue it contacts in a direction that is different than adjacent facets.

Abstract: An intervertebral disc surgical system has at least one optical cannula configured with a working channel and an optical channel, wherein the working channel and the optical channel are positioned parallel to one another. The working channel is configured to receive the elongated tubular member of an electrosurgical instrument and the optical channel is configured to receive an optical scope. The optical cannula has an optical cannula operative end for entering an operative field of a patient.

Abstract: A dilation introducer for orthopedic surgery is provided for minimally invasive access for insertion of an intervertebral implant. The dilation introducer may be used to provide an access position through Kambin's triangle from a posterolateral approach. A first dilator tube with a first longitudinal axis is provided. A second dilator tube may be introduced over the first, advanced along a second longitudinal axis parallel to but offset from the first. A third dilator tube may be introduced over the second, advanced along a third longitudinal axis parallel to but offset from both the first and the second. An access cannula may be introduced over the third dilator tube. With the first, second, and third dilator tubes removed, surgical instruments may pass through the access cannula to operate on an intervertebral disc and/or insert an intervertebral implant.

Abstract: Systems having flexible electrical leads for use in medical procedures are described herein. The leads include one or more flexible electrodes having a relatively large surface area but with sufficient flexibility so as to allow the lead to fit within and be advanced through Tuohy, Sprotte and/or other types of non-coring needles.

Abstract: Systems and methods are disclosed for implanting a passive implantable stimulator device to targeted excitable tissue, such as nerves, for treating chronic pain, inflammation, arthritis, sleep apnea, seizures, incontinence, pain associated with cancer, incontinence, problems of movement initiation and control, involuntary movements, vascular insufficiency, heart arrhythmias, obesity, diabetes, craniofacial pain, such as migraines or cluster headaches, and other disorders. In certain embodiments, a device may be used to send electrical energy to targeted nerve tissue by using remote radio frequency (RF) energy without cables or inductive coupling to power a passive implanted wireless stimulator device. The targeted nerves can include, but are not limited to, the spinal cord and surrounding areas, including the dorsal horn, dorsal root ganglion, the exiting nerve roots, nerve ganglions, the dorsal column fibers and the peripheral nerve bundles leaving the dorsal column and brain.

Abstract: An endoluminal needle or punch is describes wherein the distal end of the endoluminal needle is able to articulate laterally out of the longitudinal axis of the steerable endoluminal needle. The endoluminal needle further comprise a blunted distal end configuration that is minimally traumatic. Under control by the user, at the proximal end of the endoluminal needle, a sharp stylet can be advanced to punch tissue and then be retracted to maximize safety. The endoluminal needle is configured for use within an introducer.

Abstract: A delivery device for tissue anchor delivery is provided. The delivery device includes a first flexible tube having a rigid distal portion attachable to a tissue anchor, a second flexible tube coaxially disposed around the first tube and a tubular sheath covering the second flexible tube. Also provided is a system which includes an imaging device coupler reversibly attached to the delivery device through guides.

Abstract: A medical instrument configured to be inserted into a body cavity comprises a body comprises a first probe at a first end, the first probe comprising a first cylindrical portion with a first outer circumferential surface of a first diameter; a first circumferential edge at a distal end of the first probe; a first distal lip projecting outwardly from the first outer circumferential surface beyond the first circumferential edge and extending for at least a part of a circumference of the first circumferential edge; and a first marker lip projecting outwardly from the first outer circumferential surface and extending for at least a part of a circumference of the first outer circumferential surface; wherein the first distal lip is positioned distal to the first marker lip; and wherein the body comprises a hollow cavity to enable a second medical instrument to pass therethrough.

Abstract: A novel posterolateral inter-muscular approach has been developed to access the cervical spine. The approach includes elevating the splenius capitis and trapezios muscles dorsally to create a window for deep spine access, wherein the window comprises: i) an anterior superior border of the trapezius muscle; ii) an anterior inferior border of the splenius capitis muscle, and iii) a posterior superior border of the levator scapulae muscle. Preferably, a device such as an implant or an instrument is then passed through the window to manipulate the spine.

Abstract: The disclosure discloses methods, devices, systems and kits for repairing, replacing and/or augmenting natural facet joint surfaces and/or facet capsules. An implantable facet joint device of one embodiment comprises a cephalad facet joint element and a caudal facet joint element. The cephalad facet joint element includes a member adapted to engage a first vertebra, and an artificial cephalad bearing member. The caudal facet joint element includes a connector adapted for fixation to a second vertebra at a fixation point and an artificial caudal bearing member adapted to engage the cephalad bearing member. The artificial caudal bearing member is adapted for a location lateral to the fixation point.

Abstract: A method of manufacturing a surgical implant includes simultaneously forming a first component and a second component of the surgical implant. Formation of the first and second components includes depositing a first quantity of material to a building platform and fusing the first quantity of material to form a first layer of the first and second components. The method of manufacturing also includes depositing a second quantity of material over the first layer of the first and second components and fusing the second quantity of material to form a second layer of the first and second components. The surgical implant is fully assembled upon the completion of the formation of the first and second components.

Abstract: An articulated fixation device is provided having a high degree of adjustability for securing a plate member thereof to a skull and at least one spinal rod thereof to a vertebral bone. In one form, an adjustable bridge member is provided that is adjustably connected to both the plate member and the spinal rod. The adjustable connections can include an upper and rearward pivot connection between the plate member and the bridge member and a lower and forward pivot connection between the spinal rod and the bridge member.

Abstract: A dual compression and distraction tool for surgical operations, the tool including a first arm having a first pivot axis, a second pivot axis, a first lever, and a first dual purpose jaw, a second arm having a third pivot axis, a fourth pivot axis, a second lever, and a second dual purpose jaw, wherein, in a first position, the first arm is pivotably connected to the second arm such that the first pivot axis is merged with the third pivot axis, to form an distraction tool, and wherein, in a second position, the first arm is pivotably connected to the second arm such that the second pivot axis is merged with the fourth pivot axis, to form a compression tool.

Abstract: Methods of applying a locking cap to a bone anchor assembly. The bone anchor assembly includes a bone anchor and an elongate rod. The bone anchor includes a body that defines a channel and has a tissue retractor coupled thereto that defines a partial pathway to the channel.

Abstract: A device for straightening and stabilizing the vertebral column, particularly for stabilizing broken vertebrae, includes a supporting implant which is plastically expandable by internal pressure. The supporting implant can be placed into the interior of a vertebral body which has been fractured under compression or between adjacent vertebral bodies. A pressure balloon to which pressure fluid can be admitted may be arranged in the interior of the supporting implant for producing the internal pressure.

Abstract: An intramedullary nail system is provided with at least one resilient, elongate nail body configured to extend axially along a medullary bone cavity, and at least one bone anchor. The bone anchor includes a distal bone engagement portion configured to secure the anchor to a bone, a proximal nail engagement portion configured to receive a portion of the nail body therethrough, and a tightening mechanism configured to move from a movable state in which the nail body may slide axially and rotate through the engagement portion and a fixed state in which the nail body is prevented from moving relative to the engagement portion. Methods of use and surgical kits are also provided.

Abstract: The present subject disclosure provides a novel design for devices and methods for straightening a curved spine by using a reduction tool to move the spine with respect to an attached bone plate.

Abstract: Various embodiments of wedge plates configured to promote bone growth are disclosed. Generally, a wedge plate comprises a first bone contact section, a second bone contact section, and a wedge section located between the first bone contact section and the second bone contact section. The wedge section is sized and configured to be received within a wedge formed in a bone. The wedge section comprises at least one feature configured to promote bone growth. A bone growth stimulant may be located within the at least one feature.

Abstract: A compression screw for applying compression at a bone joint. The compression screw includes an axial screw body extending from a distal end to a proximal end with the distal end including a series of bone engaging threads configured to be self-drilling and self-tapping and the proximal end including a head which defines a radially extending shoulder. At least one proximal rotary cutting structure is defined proximally of the bone engaging threads. The at least one proximal rotary cutting structure is configured to be self-drilling such that a proximal portion of the axial screw body cuts into and advances within a bone of the bone joint as the axial screw body is advanced. A method of inserting the compression screw is also provided.

Abstract: An example bone screw is described herein. The bone screw can include a drill bit portion configured to create a pilot hole in a bone of a subject, and a threaded portion arranged proximally with respect to the drill bit portion. The threaded portion can be configured for securing the bone screw in the bone of the subject. Additionally, an outer diameter of the drill bit portion is smaller than an outer diameter of the threaded portion.

Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.

Abstract: A treatment system includes a pair of holding members, a high-frequency energy output section, a heat generating section and a control section. At least one of the pair of holding members moves to the other holding member. The high-frequency energy output section and the heat generating section are provided on at least one of the holding members. The high-frequency energy output section exerts high-frequency energy to a living tissue to denature the living tissue, and collects the biological information of the living tissue. The heat generating section applies heat to it held between the holding members, generates the heat owing to the supply of the energy, and conducts the heat therefrom to denature the living tissue. The control section controls the output of the energy to the high-frequency energy output section and the heat generating section based on the biological information collected by the high-frequency energy output section.

Abstract: A system that produces temperature estimations of a tissue surface comprises a base including a motion unit. A fiber assembly includes at least one fiber constructed and arranged to receive infrared energy from the tissue surface, the fiber assembly transmissive of infrared energy; the fiber assembly including a proximal end, a distal end and a body. An optical element redirects received infrared energy to the distal end of the fiber optic. A linkage is coupled between the base and the optical element, the fiber extending through the linkage, the linkage coupled to the motion unit at a proximal end and the optical element at a distal end, the motion unit constructed and arranged to rotate the linkage about the fiber assembly to thereby rotate the optical element at the distal end.

Abstract: A surgical device multi-socket for a high-frequency generator for connecting an electro-surgical instrument, an electro-surgical high-frequency generator, an electro-surgical device plug and an electro-surgical system. The invention also relates to a cable for an electro-surgical instrument and an electrosurgical instrument. In particular, the invention relates to a surgical device multi-socket for a high-frequency generator for connecting an electro-surgical instrument, in particular a bipolar applicator, including a coaxial socket which is designed to accommodate the coaxial plug element, and a first contact opening which is designed to accommodate a contact pin, and/or a second contact opening which is designed to accommodate a contact pin.

Abstract: An electrosurgical instrument has a power supply operatively coupled to an end effector. The end effector has a pair of jaws for effectuating an action on tissue positioned therebetween. The power supply is configured to input a first signal and a second signal to a buck-boost converter. The buck-boost converter is configured to transmit an output to an H-bridge circuit. The H-bridge circuit is configured to pass a signal to a resonant LC transformer circuit. The power supply is configured to transmit a power signal. The pair of jaws are operatively coupled to the power supply to receive the power signal, the power having no more than 80 Volts RMS, and less than 2 Amps RMS. The power is configured to seal the tissue positioned between the pair of jaws in 3 seconds or less.

Abstract: Methods for treating sleep disorders and for reducing a risk associated with developing a sleep disorder in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with sleep disorders as well as an increased risk of developing a sleep disorder. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to a sleep disorder status in the patient. Other aspects are directed to reducing a likelihood of developing a sleep disorder in patients presenting one or more sleep disorder risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's sleep disorder status or risk of developing a sleep disorder. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g.

Abstract: Methods, devices, and systems related to electrosurgical tools are provided. The electrosurgical tools can include an electrode formed of non-linear resistance material for allowing energy to be transmitted to the electrode for heating the electrode or to tissue adjacent the electrode for heating the tissue. Such transmission of the energy can depend upon a characteristic of the electrical energy, such as voltage or frequency of the energy, which can affect the resistance properties of the electrode.

Abstract: A surgical device includes a shaft, first and second end effectors extending distally from the shaft in spaced-apart relation relative to one another to define an area therebetween, and a resection member configured for positioning at least partially within the area defined between the first and second end effectors. Each of the first and second end effectors includes opposing portions movable relative to one another and configured to grasp tissue therebetween. The resection member is configured to extend distally beyond the first and second end effectors, is selectively energizable, and is configured to resect tissue grasped between the first and second end effectors.

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes at the distal ends of the guide tubes allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered to ablate nerves outside of the media.

Abstract: A catheter has a two-piece tip electrode with a shell and a support structure defining a chamber, and a fluid distribution tube that extends longitudinally into the chamber, the fluid tube having fluid apertures along its length for distributing fluid more uniformly distributed throughout the chamber for improved cooling and thus minimizing the risk of char formation on regions of the tip electrode more prone to overheating.

Abstract: Apparatus, including a catheter configured to be inserted into an organ of a human body. A plurality of electrodes are deployed on the catheter, the electrodes being configured to transfer radiofrequency (RF) ablation energy to tissue of the organ. The apparatus also includes a power supply configured to supply the RF ablation energy at a level of up to 100 W to each of the plurality of electrodes simultaneously, so as to ablate respective sections of the tissue of the organ in contact with the electrodes.

Abstract: Methods for treating depression and for reducing a risk associated with developing depression in patients via therapeutic renal neuromodulation and associated systems are disclosed herein. Sympathetic nerve activity can contribute to several cellular and physiological conditions associated with depression as well as an increased risk of developing depression. One aspect of the present technology is directed to methods for improving a patient's calculated risk score corresponding to a depression status in the patient. Other aspects are directed to reducing a likelihood of developing depression in patients presenting one or more depression risk factors. Renal sympathetic nerve activity can be attenuated to improve a patient's depression status or risk of developing depression. The attenuation can be achieved, for example, using an intravascularly positioned catheter carrying a therapeutic assembly configured to use, e.g.

Abstract: Systems are provided for assessing the likelihood that a sample of cardiac tissue will spontaneously exhibit disordered electrical activity. These systems induce ventricular tachycardia or other disordered electrical activity in a sample of human and/or animal cardiac tissue either in vivo or in vitro. This system can be used to assess the ability of various pharmaceuticals, genetic modifications, electrical pacing, surgical ablation, or other therapeutic interventions to prevent or halt such disordered electrical activity. This system detects electrical activity from a plurality of points on the surface of the sample of cardiac tissue and generates one or more maps of monophasic action potential amplitude, monophasic action potential duration, local field amplitude, or other electrophysiological parameters of the cardiac tissue.

Abstract: A radio frequency ablation device includes a balloon blocking catheter. The radio frequency ablation device comprises a double or multi-chamber balloon blocking catheter and a radio frequency ablation catheter. An electrode support is arranged at the far end of the radio frequency ablation catheter. Two or more electrodes are arranged on the electrode support, and are connected to a radio frequency generator respectively by means of the corresponding guide wires arranged in the radio frequency ablation catheter. When the radio frequency ablation device is used for ablating lumen peripheral nerves, inflating a closed balloon arranged at the far end of the guide catheter to block local blood flow in a blood vessel.

Abstract: An ablation catheter comprises an elongated catheter body; at least one ablation element disposed in a distal portion which is adjacent the distal end of the catheter body; an illumination optical element disposed in the distal portion, the illumination optical element being light-transmissive to emit light from the illumination optical element to the targeted tissue region; and a collection optical element disposed in the distal portion, the collection optical element being light-transmissive to collect one or more of returned, backscattered or newly excited light from the targeted tissue region. The illumination or excitation optical element and the collection optical element are axially spaced from one another and axially optically isolated from one another within the distal portion to substantially prevent light from traveling between the illumination optical element and the collection optical element along a path within the distal portion.