Patents Issued in January 24, 2019
  • Publication number: 20190021956
    Abstract: An apparatus for counting and dispensing tablets includes a vibratory tablet feeder for feeding tablets to be counted to an output opening, at least one electrically-controlled vibrator coupled to the tablet feeder for vibrating the tablet feeder such that a singulated flow of tablets exits the output opening, and an optical system including at least one light source and at least one detector array located about a channel disposed downstream from the output opening of the tablet feeder. The optical system is configured to count tablets that pass through the channel as well as determine a tablet size class for the tablets that pass through the channel. Operation of the at least one electrically-controlled vibrator is controlled based on the tablet size class determined by the optical system.
    Type: Application
    Filed: July 20, 2017
    Publication date: January 24, 2019
    Applicant: Capsa Solutions, LLC
    Inventors: Aleksandr R. Geltser, Samuel Dworkin
  • Publication number: 20190021957
    Abstract: Described herein are dental compositions, more particularly water soluble dental varnish composition useful for effective fluoridation, in situ biomimetic remineralization and improved adhesion to enamel. The dental composition includes a hydrogel-forming polymer having cohesive properties to itself and adhesive properties to a dental enamel. The hydrogel forming polymer includes a water-soluble polymer and an adhesion promotor chemically and/or physically conjugated to the water-soluble polymer. The embodiments also provide methods of forming a hydrogel forming polymer and use of hydrogel forming polymer to prepare such dental composition.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 24, 2019
    Applicant: DENTSPLY SIRONA Inc.
    Inventors: Amit JHA, Thomas C. SIMONTON
  • Publication number: 20190021958
    Abstract: A dental device is improved in its ability to produce hydroxyl apatite by having a layer of mineral trioxide aggregate (MTA) deposited thereon. A tile of MTA is prepared, heat treated and sintered to produce a micronized tile of MTA that can then be deposited by physical vapor depositions, hot isostatic pressing, molding or other conventional technique.
    Type: Application
    Filed: May 7, 2018
    Publication date: January 24, 2019
    Applicant: DENTSPLY SIRONA, Inc.
    Inventors: Kevin Wilkinson, Geoffrey Ndungu
  • Publication number: 20190021959
    Abstract: The present invention relates to an aqueous dispersed color composition with a high pigment content and an aqueous nail polish composition using the same, and more particularly, to an aqueous dispersed color composition containing an alkaline resin aqueous solution including an alkali-soluble resin having a weight-average molecular weight of 3,000 to 20,000 and an aqueous dispersed emulsion resin having a weight-average molecular weight of 100,000 to 300,000, so that the aqueous dispersed color composition stably contains a high pigment content in a dispersed state, no color deformation, occur in a pigment, and dispersion stability and color expression of the pigment are excellent. In addition, an aqueous nail polish composition using the aqueous dispersed color composition is easily mixed with pigments, and the aqueous nail polish composition has excellent gloss property, color expression, adhesion property, and storage stability even when stored for a long period of time.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 24, 2019
    Inventor: Hyoung jin Min
  • Publication number: 20190021960
    Abstract: Aerosol shower foam preparations that are suitably mild, have a creamy dense foam and are packaging-compatible.
    Type: Application
    Filed: February 13, 2017
    Publication date: January 24, 2019
    Inventors: Rixa DIPPE, Romy KIENAST, Kirsten SCHNEIDER, Ina SCHORNSTEIN, Britta FISCHER
  • Publication number: 20190021961
    Abstract: The present invention relates to a water-in-oil emulsion and its use as a skin care product, in particular as a cosmetic and as a (dermatologic) medicament for aged skin. The emulsion contains a disperse/internal aqueous phase comprising an ?-hydroxy-C2-C6-carboxylic acid, a continuous/external oil phase and an emulsifier system, comprising polyglyceryl-3-polyricinoleate, sorbitan oleate and sucrose polystearate, wherein the emulsion has a pH of 1 to 5.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventors: Christoph Abels, Ulrich KNIE
  • Publication number: 20190021962
    Abstract: The present disclosure relates to fragrance materials encapsulated within polymeric materials in the form of microcapsules of polymer encapsulated fragrance. The microcapsules are mixed with a water-based binding agent so that a coating forms on the microcapsule in situ, after which the coated microcapsules may be applied to hard surfaces of a product, from which controlled release of the fragrance is provided over time as the product is subjected to normal handling by a user.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 24, 2019
    Inventor: Raymond E. Guerry
  • Publication number: 20190021963
    Abstract: The present invention provides a tooth whitening oral care composition comprising: (i) a dye having a blue to blue-violet color with a hue angle in the CIELAB system ranging from 200 to 320 degrees; (ii) core shell silica particles, wherein each core shell silica particle comprises a silica core, and a surface of the silica core is etched with metal silicate; (iii) an orally acceptable carrier vehicle comprising a non-aqueous solvent; and wherein the composition comprises water in an amount of from 3 weight % to 30 weight %.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 24, 2019
    Applicant: COLGATE-PALMOLIVE COMPANY
    Inventors: Venda MALONEY, Suman CHOPRA, Hallena STROTMAN, Guisheng PAN
  • Publication number: 20190021964
    Abstract: Antiperspirant sticks containing (A) at least one perspiration-inhibiting substance from the group formed by aluminium or aluminium-zirconium salts (B) at least one hydrophobic carrier material (C) behenyl behenate (D) behenate from the group formed by cetyl behenate and stearyl behenate, wherein the ratio of the proportion by weight of the behenyl behenate (C) with respect to the total weight of the antiperspirant stick to the proportion by weight of the behenate from the group formed by cetyl behenate and stearyl behenate with respect to the total weight of the antiperspirant stick is 4:1 to 1:4, and a method employing said antiperspirant sticks.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 24, 2019
    Applicant: Henkel AG & Co. KGaA
    Inventors: Thomas Doering, Stefanie Schmitz
  • Publication number: 20190021965
    Abstract: Chemical membrane complex (CMC) in hair strands is damaged by exposure to environmental factors, and by hair processing methods that use basic solutions to permanently reshape and/or recolor hair. A CMC repair solution contains components of CMC that repair CMC while cuticle cells are lifted following coloring or perming. Hair treatment with CMC repair solution quenches reactive chemicals on hair and rebuilds damaged CMC on hair. Hair treatment with some embodiments of CMC repair solution lowers cuticle cells by reducing hair pH. Application of CMC repair solution to cuticle-lifted hair strands allows permanent hair reshaping and permanent hair coloring in a single treatment session without loss of cuticle cells or associated hair damage.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 24, 2019
    Inventor: Camie PARSONS
  • Publication number: 20190021966
    Abstract: Described herein are dental compositions, more particularly water soluble dental varnish composition useful for effective fluoridation, in situ biomimetic remineralization and improved adhesion to enamel. The dental composition includes a hydrogel-forming polymer having cohesive properties to itself and adhesive properties to a dental enamel. The hydrogel forming polymer includes a water-soluble polymer and an adhesion promotor chemically and/or physically conjugated to the water-soluble polymer. The embodiments also provide methods of forming a hydrogel forming polymer and use of hydrogel forming polymer to prepare such dental composition.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 24, 2019
    Applicant: DENTSPLY SIRONA Inc.
    Inventors: Amit JHA, Thomas C. SIMONTON
  • Publication number: 20190021967
    Abstract: Film-forming compositions comprising a film forming polymer containing acid groups and a neutralizing agent; compositions and methods for increasing the SPF of a composition by neutralizing at least a portion of the acid groups of the film forming agent with the neutralizing agent.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventors: Qiwei HE, Michael T. PHILBIN, Gary T. MARTINO, Thomas A. MEYER, Donathan G. BEASLEY, John H. WAGNER, JR.
  • Publication number: 20190021968
    Abstract: Hair treatment agents containing a mixture of special linear alkanes, an amidoamine and/or a cationized amidoamine, and at least one cationic surfactant (esterquat and/or quarternary ammonium compound) are provided. In one example, the hair treatment agents are suitable for the care of hair, in particular to improve the wet and dry combability, the disentanglement, the hold, and the gloss of hair.
    Type: Application
    Filed: June 28, 2018
    Publication date: January 24, 2019
    Applicant: Henkel AG & Co. KGaA
    Inventors: Edith von Aspern, Dirk Hentrich, Manuela Mette, Thomas Schroeder, Soeren Scheele
  • Publication number: 20190021969
    Abstract: The disclosure provides personal care compositions that comprise a moisturizing agent of formula (I) wherein n is an integer from 2 to 5, R1 is independently H or C1-C3 alkyl and R2 is an unsubstituted linear or branched C1-C6 alkyl, at least one additional moisturizing agent and a cosmetically acceptable vehicle. In particular, the compound of formula (I) is diglycolamine acetamide. The compositions generally improve moisturization of skin and hair.
    Type: Application
    Filed: September 13, 2016
    Publication date: January 24, 2019
    Inventors: Qiwei HE, Hanamanthsa BEVINAKATTI
  • Publication number: 20190021970
    Abstract: The disclosure provides personal care compositions that comprise a compound of formula (I) wherein n is an integer from 2 to 5, R1 is independently H or C1-C3 alkyl and R2 is an unsubstituted linear or branched C1-C6 alkyl and a cosmetically acceptable vehicle. In particular, the compound of formula (I) is diglycolamine acetamide The composition may be used to moisturise skin or hair.
    Type: Application
    Filed: September 13, 2016
    Publication date: January 24, 2019
    Inventors: Qiwei HE, Hanamanthsa BEVINAKATTI
  • Publication number: 20190021971
    Abstract: Hair cleansing products containing anionic surfactants, amphoteric surfactants, a mixture of specific linear alkanes and a non-polymeric structuring agent, suitable for the cleansing and nourishing of hair, in particular in order to improve the wet and dry combability, the detangling capability, the feel, and the shine of hair.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 24, 2019
    Applicant: Henkel AG & Co. KGaA
    Inventors: Thomas Schroeder, Edith von Aspern, Dirk Hentrich, Manuela Mette, Soeren Scheele
  • Publication number: 20190021972
    Abstract: Compositions containing one or more alkyl lactate sulfate (A) of the general formula (I), R1(OCOCH(CH3))nOSO3M1??(I) in which the radical R1 is a linear or branched alkyl or alkenyl radical having 6 to 30 carbon atoms, the index n is a number in the range from 1 to 5, and the radical M1 is selected from H, Li, Na, K, Ca/2, Mg/2, ammonium, and alkanolamine, one or more compound (B) selected from phosphoric acid and the mono-, di- and tri-salts thereof, wherein the cation of these salts is selected from Li, Na, K, Ca, Mg, ammonium, and alkanolamine, one or more compound (C) selected from citric acid and the mono-, di- and tri-salts thereof, wherein the cation of these salts is selected from Li, Na, K, Ca, Mg, ammonium, and alkanolamine, and water where the following provisos apply: the weight ratio of the sum total of the compounds (B) and (C) to the sum total of the compound (A) is in the range from 1:5 to 1:10.
    Type: Application
    Filed: January 19, 2017
    Publication date: January 24, 2019
    Inventors: Ansgar Behler, Frank Clasen, Claudia Brunn, Laurence Pottie, Monika Barbenheim, Daniel Hoff
  • Publication number: 20190021973
    Abstract: The present disclosure provides biophotonic topical compositions, kits and their uses. In some aspects, the biophotonic topical compositions of the present disclosure comprise a first chromophore, a salt selected from one or more bicarbonate or carbonate salts or a combination of the foregoing salts, and one or more gelling agents. In some aspects, the biophotonic topical compositions of the present disclosure comprise a first chromophore, one or more polyols, and one or more gelling agents. The biophotonic compositions of the present disclosure do not include an oxidant selected from the group consisting of a peroxide, a peroxy acid, hydrogen peroxide, carbamide peroxide, an alkali metal peroxide, an alkali metal percarbonate, peroxyacetic acid, and an alkali metal perborate. The biophotonic compositions are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.
    Type: Application
    Filed: December 28, 2016
    Publication date: January 24, 2019
    Inventors: Francesco BELLINI, David OHAYON, Remigio PIERGALLINI, Nikolaos LOUPIS, William CURTIS
  • Publication number: 20190021974
    Abstract: The present invention relates to cosmetic or personal care compositions comprising two or more compounds, each compound containing an allylic or partially allylic carbonyl substructure having the following structure I: wherein Y is a second substructure immediately adjacent to the allylic or partially allyliccarbonyl substructure and is selected from one of the following groups consisting of (i) hydroxyl-based group including —OH or —C(?)—(OH); (ii) carbonyl-based group including —C(?)—C (?O)—CH3; (iii) ether group, —O—; (iv) sultam group, —N(H)—S(?O)2—; (v) lactam group, —N(H)—C(?O)—; (vi) apolar group including cyclic structures based on menthol or carotenoids; (vii) secondary aldimine containing group including —N(H)—C(NH2)?N— or —N(H)—C(H)?N—; (viii) amine group, —NH2; (ix) secondary amine-based group, —N(H)—; and (x) amide-based group including —N(H)—C(?O)— or —N(H)—C(?O)—N(H)—, their derivatives, isomers, salts and/or combination thereof; and a cosmetically acceptable vehicle.
    Type: Application
    Filed: January 19, 2017
    Publication date: January 24, 2019
    Inventors: Peter Samuel James Cheetham, Christoph Langwallner, Margit Langwallner, Wen Jue Amelia Tan
  • Publication number: 20190021975
    Abstract: The present invention relates to a composition and a deodorizing preparation comprising such composition for reducing, inhibiting or suppressing malodour developed from a body part of a subject. The composition comprises an active ingredient in an effective amount, the active ingredient comprising one or more of a hexamine, a derivative thereof and a compound thereof. The composition further comprises a buffer system adapted to maintain pH of the composition within a range of about 7.0 to about 11.0 when the composition is applied on the body part. The buffer system is adapted to substantially neutralise topical acidity of the body part to thereby reduce or minimise generation of skin-irritating formaldehyde from the hexamine comprising active ingredient.
    Type: Application
    Filed: October 23, 2017
    Publication date: January 24, 2019
    Inventor: Chung Hing Lao
  • Publication number: 20190021976
    Abstract: The present invention relates to a photoaging inhibitor, and more specifically it relates to a pharmaceutical composition, a food composition or a cosmetic composition for preventing, improving or treating photoaging of skin, comprising DHPV (5-(3?,4?-Dihydroxyphenyl)-?-valerolactone) which is a metabolite of cacao. Since DHPV, an active ingredient comprised in the composition according to the present invention is a metabolite of cacao which is a botanical raw material harmless to human body and is not only excellent in biosafety, but also regulates expression of proteins related to skin aging epigenetically, thereby exhibiting an excellent skin aging-preventing function at a low concentration of 1 nM based on skin cells, the composition comprising the same is excellent in use as medicines, cosmetics and foods for preventing, improving and treating skin aging.
    Type: Application
    Filed: November 10, 2017
    Publication date: January 24, 2019
    Inventors: David Tae Aug KIM, Dong Hyun Kim, A-Ram Kim
  • Publication number: 20190021977
    Abstract: Disclosed herein are oral care compositions including Zn:usnate complexes having a 1:2 zinc to usnate molar ratio. Methods of making and using the compositions are also provided.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 24, 2019
    Applicant: Colgate-Palmolive Company
    Inventors: Stanislav JARACZ, Long PAN, Karthik SAMBANTHAMOORTHY
  • Publication number: 20190021978
    Abstract: The present invention relates to a composition of aqueous gel type comprising from 7.5% to 13.5% by dry weight, relative to its total weight, of at least one modified crosslinked C1-C4 carboxyalkyl starch and at least one C2-C5 monoalcohol. A composition according to the invention is in particular of use as a skin cleansing mask, in particular a face cleansing mask. The invention also relates to a process for the preparation thereof, to a process for cosmetic treatment of keratin materials and to a cosmetic process for cleansing a keratin material.
    Type: Application
    Filed: December 20, 2016
    Publication date: January 24, 2019
    Inventors: Emmanuelle CAMBLONG, Céline MARCQ, Valérie PAGE
  • Publication number: 20190021979
    Abstract: This invention relates to the use of microgranules comprising destructurized starch in a complexed form as abrasive and/or structuring agents in cosmetic, dermatological, detergent and cleansing formulations.
    Type: Application
    Filed: January 18, 2017
    Publication date: January 24, 2019
    Inventors: Paolo MAGISTRALI, Nicola MARINI, Ioanna PETRAKOU
  • Publication number: 20190021980
    Abstract: The subject matter of the present disclosure is a method for treatment keratinous fibers which make it possible to color the hair in a single treatment session and simultaneously achieve a multi-tonal coloring with sections (strands) having different colors, more particularly lighter (“highlights”) sections (strands), wherein the use of solid, flat separating aids, more particularly foils from solid materials such as aluminum, paper or Styrofoam and similar materials is not required.
    Type: Application
    Filed: December 1, 2016
    Publication date: January 24, 2019
    Applicant: Henkel AG & Co. KGaA
    Inventors: Hartmut Manneck, Stefan Hoepfner, Matthias Schweinsberg
  • Publication number: 20190021981
    Abstract: The invention relates to multiphasic polymers comprising from 45% to 95% by weight of a first polymer P1 and from 5% to 55% by weight of a second polymer P2, said polymers P1 and P2 being of distinct compositions, said polymer P1 being obtained by polymerization from a mixture of monomers comprising at least one anionic monomer (a) having a polymerizable vinyl group, at least one nonionic hydrophobic monomer (b) having a polymerizable vinyl group, at least one cross-linking monomer (c) and at least one associative monomer (d) having a polymerizable vinyl group and a hydrophobic hydrocarbon chain and said polymer P2 being obtained by polymerization from a mixture of monomers comprising at least one anionic monomer (a?) having a polymerizable vinyl group, at least one nonionic hydrophobic monomer (b?) having a polymerizable vinyl group and at least one cross-linking monomer (c?).
    Type: Application
    Filed: October 30, 2015
    Publication date: January 24, 2019
    Applicant: COATEX
    Inventors: Clementine CHAMPAGNE, Jean-Marc SUAU, Benoit MAGNY, Delphine BONY, Yves KENSICHER
  • Publication number: 20190021982
    Abstract: A water absorbing resin has a siloxane skeleton which is a copolymer containing a structural unit derived from a polymerizable vinyl monomer (A) shown by the general formula (1), a structural unit derived from a polymerizable vinyl monomer (B) shown by the general formula (3), and a structural unit derived from an organopolysiloxane (C) having polymerizable groups at the both terminals thereof shown by the general formula (4). The water absorbing resin has a siloxane skeleton that is capable of thickening an aqueous composition without making it sticky, together with a cosmetic containing the same.
    Type: Application
    Filed: December 13, 2016
    Publication date: January 24, 2019
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Hiroomi IYOKU
  • Publication number: 20190021983
    Abstract: The present invention relates to a process for treating keratin fibres, in particular human keratin fibres such as the hair, comprising: 1) a step of applying to the keratin fibres a composition comprising: a) one or more compounds chosen from urea and/or urea derivatives, b) one or more polyols, c) one or more amino silicones, 2) a step of heat treatment of the keratin fibres, the heat treatment step 2) preferably being after step 1). The present invention also relates to a composition that may be used in the process according to the invention.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 24, 2019
    Inventors: Guillaume RONCHARD, Manon CHAUMONTET, Renaud SOUCHAY
  • Publication number: 20190021984
    Abstract: The present invention relates to bioactive compositions (including, for example, bioactive serum fractions and bioactive extracts) derived from ginseng (Panax spp.) fresh whole plant, a particular part of the plant (e.g., rhizome, roots, leaves, stems, flowers, fruit) or any combination of these plant parts. The bioactive serum fractions and bioactive extracts are free of or substantially free of pulegone and/or free of or substantially free of proteins. The present invention also provides products comprising the bioactive serum fractions and/or bioactive extracts. The present invention further provides methods of making and using the bioactive serum fractions and/or bioactive extracts. Further, the bioactive serum fractions and bioactive extracts have anti-inflammatory and/or anti-irritant and/or anti-aging activities.
    Type: Application
    Filed: January 16, 2017
    Publication date: January 24, 2019
    Applicant: ISP INVESTMENTS LLC
    Inventors: Michael KOGANOV, Olga DUEVA-KOGANOV, Paul RECHT, Artyom DUEV, Li ZHANG, Steven MICCERI, Robert TURNER
  • Publication number: 20190021985
    Abstract: Disclosed is a mucoadhesive pharmaceutical composition comprising a poly-ionic complex of chitosan and a polyacrylic acid polymer. As an oral formulation, the composition has the extended retention time in the gastrointestinal tract by its mucoadhesive and swelling properties, which is useful as sustained release formulations, retentive formulations of active ingredients with limited absorption regions, and active ingredients with pH dependent solubility.
    Type: Application
    Filed: December 29, 2016
    Publication date: January 24, 2019
    Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATION
    Inventors: Sang Yeob PARK, Jong Won YOON
  • Publication number: 20190021986
    Abstract: The invention relates to a new composite based on hydroxypropyl-?-cyclodextrin, sucralose, a pharmaceutically active ingredient (API) complexed in said hydroxypropyl-?-cyclodextrin, and optionally an aqueous vehicle. The composite is obtainable by a complexation process of the API in hydroxypropyl-?-cyclodextrin, carried out in the presence of sucralose. The composite ensures a surprisingly high API bioavailability through buccal route of absorption, due to a high absorption rate through the oral membrane. The composite is therefore suitable for the preparation of oromucosal pharmaceutical compositions, e.g. buccal or sublingual tablets, orodispersible film, etc., having high bioavailability.
    Type: Application
    Filed: February 24, 2017
    Publication date: January 24, 2019
    Applicant: Altergon S.A.
    Inventors: Lorenzo BELLORINI, Luca NOCELLI, Tiziano FOSSATI
  • Publication number: 20190021987
    Abstract: A device for vaporizing a composition. The device comprises a thermally conductive substrate having a surface, the surface comprising a thermally conductive surface structure. A dry composition capable of a solid to liquid phase change upon being heated to at least a select temperature is disposed on the surface structure. The surface structure is configured to form liquid droplets of the composition upon heating of the surface structure to at least the select temperature. The liquid droplets have a median diameter less than a median diameter of liquid droplets formed on a planar substrate surface heated to at least the select temperature.
    Type: Application
    Filed: July 24, 2018
    Publication date: January 24, 2019
    Inventors: C.V. Krishnamohan Sharma, Mingzu Lei, Peter D. Noymer, Daniel J. Myers
  • Publication number: 20190021988
    Abstract: Improved formulations that combine chemical permeation enhancers with additional agents so that the formulations simultaneously penetrate both lipid and cellular matrices provide effective transdermal delivery of active agents.
    Type: Application
    Filed: January 23, 2017
    Publication date: January 24, 2019
    Inventor: Bruce J. SAND
  • Publication number: 20190021989
    Abstract: The present invention relates to pharmaceutical compositions comprising a drug for topical administration, e.g. a TLR7 modulator. More specifically it relates to a pharmaceutical composition comprising a benzo[f][1,7]naphthyridine derivative.
    Type: Application
    Filed: January 21, 2016
    Publication date: January 24, 2019
    Applicant: NOVARTIS AG
    Inventors: Catherine CANTINA, Paul FERNANDES, Melinda Eniko GRUBESA, Claire HAUG, Michael KELLER, Isabelle RAULT
  • Publication number: 20190021990
    Abstract: The invention provides artificial tear compositions comprising one or more nonionic surfactants with one or more non-Newtonian viscosity enhancing excipients and menthol and methods of their use.
    Type: Application
    Filed: September 21, 2018
    Publication date: January 24, 2019
    Inventor: Gerald Horn
  • Publication number: 20190021991
    Abstract: Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. In several embodiments, the devices are configured to release a pro-drug form of a drug into a target tissue site, wherein the pro-drug is converted to an active drug that yields a therapeutic effect. The use of the device and pro-drug form advantageously, in several embodiments, provide a stable drug composition that can yield a therapeutic effect over an extended time period.
    Type: Application
    Filed: November 12, 2014
    Publication date: January 24, 2019
    Inventors: Harold A. Heitzmann, Kenneth M. Curry, David S. Haffner
  • Publication number: 20190021992
    Abstract: The invention relates to a semi-solid composition comprising at least one cadotril and at least one liquid-lipid and/or polyol and/or glycerol and/or propylene glycol excipient, a dose unit comprising the semi-solid composition as well as use and a method of treating a subject suffering from a disease or disorder in the gastro intestinal tract.
    Type: Application
    Filed: January 9, 2017
    Publication date: January 24, 2019
    Inventors: SALIH MUHSIN MUHAMMED, KATARINA LINDELL, ANDREAS HUGERTH
  • Publication number: 20190021993
    Abstract: An antibacterial breathing strip for nasal decongestant and cough suppressant includes a flexible sheet and an enclosing panel that is traversed with a plurality of ventilation openings. The flexible sheet and the enclosing panel are perimetrically connected to each other while enveloping a filter pad that is saturated with a quantity of antibiotic ointment. The antibacterial breathing strip is intended to externally couple with a mask so that when an individual breathes into the mask the user aromatically inhales the ointment properties, which is controlled and released from the breathing strip via designated ventilation openings, to promote nasal decongestant, suppressing coughs, the removing of sinus pressure, and the removing of sinus headaches and bronchitis.
    Type: Application
    Filed: July 19, 2017
    Publication date: January 24, 2019
    Inventor: Leo GREEN
  • Publication number: 20190021994
    Abstract: Dry powder formulations for inhalation comprising a combination of an anticholinergic, a long-acting beta2-adrenoceptor agonist, and, optionally, an inhaled corticosteroid are useful for the prevention and/or treatment of an inflammatory and/or obstructive airways disease.
    Type: Application
    Filed: August 27, 2018
    Publication date: January 24, 2019
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Claudio CAFIERO, Leonardo ORTENZI
  • Publication number: 20190021995
    Abstract: The invention belongs to the field of pharmaceutics and relates to formulations for external use for the treatment of peripheral joints, spinal joints and/or extracellular matrix elements of connective tissue. The claimed formulation provides for superior (in comparison to existing analogs) transdermal delivery of pharmaceutically active ingredients, in particular, glucosamine sulfate or other glucosamine salts, and additional ingredients to affected joints. Also proposed is a method of producing said formulation and therapeutic use thereof. The efficacy of the proposed formulation is confirmed by clinical test results.
    Type: Application
    Filed: December 30, 2015
    Publication date: January 24, 2019
    Inventors: Alexander Vilenovich ASAFOV, Livio ORSINI GRAVINA
  • Publication number: 20190021996
    Abstract: A therapeutic preparation and article treated with tourmaline nano-particles and a method of manufacturing the same. The therapeutic preparation comprises a gel and tourmaline nano-particles held in suspension in said gel. The therapeutic article comprises a fabric and tourmaline particles attached to said fabric. In one embodiment, an adhesive containing tourmaline is applied to non-treated fabric to form the article. In another embodiment, the tourmaline is integral to the fabric. A method of manufacturing the therapeutic article comprises the steps of submerging a fabric in an aqueous solution comprising tourmaline nano-particles and drying said fabric.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventor: Gregory A. Rivera
  • Publication number: 20190021997
    Abstract: A pharmaceutical composition of high drug loading comprising an active pharmaceutical ingredient (API) and pharmaceutical acceptable additives, which include glass-solution forming additive and/or eutectic-mixture forming additive, is provided. The composition is dispersed uniformly to form a hybrid solid dispersion consisting of crystalline-suspension, glass-solution and/or eutectic-mixture, where the crystalline API is uniformly distributed in the hybrid solid dispersion and exists in nano/micro particle size range. The amorphous API, when present, is uniformly distributed in the hybrid solid dispersion. The API may exist in different chemical and/or physical forms. The API is present in an amount of from more than about 50% wt/wt to about 90% wt/wt with respect to the total amount of the active pharmaceutical ingredient and the pharmaceutically acceptable glass-solution forming and/or eutectic-mixture forming additives.
    Type: Application
    Filed: November 3, 2017
    Publication date: January 24, 2019
    Applicant: AcryPharm LLC
    Inventor: Hsien-Hsin TUNG
  • Publication number: 20190021998
    Abstract: The present invention relates to therapeutic nanoemulsion compositions and to methods of utilizing the same to treat a burn wound. In particular, nanoemulsion compositions are described herein that find use in reducing and/or preventing progression/conversion of a partial thickness burn wound (e.g., to deep partial thickness wound or a full thickness burn wound (e.g., by accelerating and/or improving burn wound healing)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine), industrial, and research applications.
    Type: Application
    Filed: July 30, 2018
    Publication date: January 24, 2019
    Inventors: Mark R. HEMMILA, James J. BAKER, JR., Vladislav A. DOLGACHEV, Susan M. CIOTTI, Suhe WANG
  • Publication number: 20190021999
    Abstract: The disclosure provides methods of manufacturing small nanoparticles of degradable polymers.
    Type: Application
    Filed: February 15, 2018
    Publication date: January 24, 2019
    Inventor: Bin Wu
  • Publication number: 20190022000
    Abstract: Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti-infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
    Type: Application
    Filed: March 13, 2018
    Publication date: January 24, 2019
    Applicant: Foamix Pharmaceuticals Ltd.
    Inventors: Dov TAMARKIN, Doron FRIEDMAN, Meir EINI
  • Publication number: 20190022001
    Abstract: The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
    Type: Application
    Filed: February 23, 2018
    Publication date: January 24, 2019
    Applicant: Foamix Pharmaceuticals Ltd.
    Inventors: Dov Tamarkin, Doron Friedman, Tal Berman, Enbal Ziv, David Schuz
  • Publication number: 20190022002
    Abstract: A liposome formulation for delivery of Wnt signal pathway inhibitor is provided herein, which comprises lipid molecules and Wnt signal pathway inhibitor, wherein Wnt signal pathway inhibitor encapsulated within the liposome formulation has a concentration ranging from 0.07 mg/ml to 0.5 mg/ml.
    Type: Application
    Filed: April 3, 2018
    Publication date: January 24, 2019
    Inventors: Yuhong Xu, Meiqing Tu, Xiaojing Chen
  • Publication number: 20190022003
    Abstract: A liposome formulation for delivery of Wnt signal pathway inhibitor is provided herein, which comprises lipid molecules and Wnt signal pathway inhibitor, wherein the liposome formulation is prepared through following steps: (1) providing an aqueous solution of the Wnt signal pathway inhibitor and providing an alcoholic solution of the lipid molecules, (2) mixing the aqueous solution of the Wnt signal pathway inhibitor and the alcoholic solution of the lipid molecules, (3) removing alcohol solvent to obtain the liposome formulation with Wnt signal pathway inhibitor encapsulated therein.
    Type: Application
    Filed: April 3, 2018
    Publication date: January 24, 2019
    Inventors: Yuhong Xu, Meiqing Tu, Xiaojing Chen
  • Publication number: 20190022004
    Abstract: The present invention relates to a pharmaceutical composition comprising a weak acid drug, with the use of a bicarbonate salt to achieve a high incorporation of the drug into the liposome and a better therapeutic efficacy. Also disclosed is a method for treating a respiratory disease using the pharmaceutical composition disclosed herein.
    Type: Application
    Filed: July 23, 2018
    Publication date: January 24, 2019
    Inventors: Pei KAN, Yi Fong LIN, Ko Chieh CHEN
  • Publication number: 20190022005
    Abstract: A process for treating tumors by administering a mixture of cancer fighting drugs incorporated into a stabilized liposomal formulation. Each cancer drug is selected to target a different phase of the cell-cycle of the cancer cell thus expanding the number of cancer cells that can be killed at one time without compromising the safety of the patient. The stabilized multi-drug liposomes are designed to extravasate thru “leaky” blood capillaries supplying the tumor and enter the tumor tissue where they will accumulate over time and ultimately release the mixture of cancer drugs to kill surrounding tumor cells. The multi-drug liposomes are likewise unable to extravasate thru normal blood capillaries and will thus be less toxic to normal tissues.
    Type: Application
    Filed: August 29, 2018
    Publication date: January 24, 2019
    Inventors: Henry J. Smith, James R. Smith