Patents Issued in January 29, 2019
  • Patent number: 10189738
    Abstract: A bushing system may include a bushing that is configured to receive a molten material. The bushing may include a plate defining a first plurality of apertures through which the molten material flows. The plate may include a longitudinal axis, as well as a first side wall and a second side wall disposed on a side of the plate opposite the first side wall. The first side wall and the second side wall may extend at an upward angle from the plate. The plate may also include a plurality of ribs extending along at least a portion of the plate. The bushing system may also include a tip plate coupleable with the bushing. The tip plate may be configured to receive the molten material from the bushing and may define a second plurality of apertures through which the molten material flows to form fibers.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: January 29, 2019
    Assignee: Johns Manville
    Inventor: Morris L Richardson, III
  • Patent number: 10189739
    Abstract: To provide chemically tempered glass which is less likely to break even if scratched. Chemically tempered glass, which comprises, as represented by mole percentage based on the following oxides, from 56 to 72% of SiO2, from 8 to 20% of Al2O3, from 9 to 25% of Na2O, from 0 to 2% of K2O, and from 0 to 15% of MgO, and which has a surface compressive stress of at least 900 MPa and an internal tensile stress of at most 30 MPa. Glass for chemical tempering, which comprises, as represented by mole percentage based on the following oxides, from 56 to 69% of SiO2, from 8 to 16% of Al2O3, from 9 to 22% of Na2O, from 0 to 1% of K2O, from 5.5 to 14% of MgO, from 0 to 2% of ZrO2, and from 0 to 6% of B2O3.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: January 29, 2019
    Assignee: AGC Inc.
    Inventors: Shusaku Akiba, Shigeki Sawamura, Suguru Murayama, Hiroyuki Ohkawa, Yusuke Kobayashi, Kazutaka Ono, Tetsuya Nakashima
  • Patent number: 10189740
    Abstract: An optical glass having a small partial dispersion ratio (?g,F), while having a refractive index (nd) and Abbe number (?d) within desired ranges, is obtained. The optical glass, in mol %, comprises 20.0 to 65.0% of an SiO2 component, 1.0 to 25.0% of an Nb2O5 component, and 1.0 to 35.0% of an Na2O component, and has a refractive index (nd) of 1.62 to 1.75, an Abbe number (?d) of 30 to 42, and a partial dispersion ratio (?g,F) of no greater than 0.594.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: January 29, 2019
    Assignee: OHARA INC.
    Inventors: Ken Kikkawa, Atsushi Nagaoka
  • Patent number: 10189741
    Abstract: Glass and glass ceramic compositions having a combination of lithium silicate and petalite crystalline phases along with methods of making the glass and glass ceramic compositions are described. The compositions are compatible with conventional rolling and float processes, are transparent or translucent, and have high mechanical strength and fracture resistance. Further, the compositions are able to be chemically tempered to even higher strength glass ceramics that are useful as large substrates in multiple applications.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: January 29, 2019
    Assignee: CORNING INCORPORATED
    Inventors: George Halsey Beall, Qiang Fu, Charlene Marie Smith
  • Patent number: 10189742
    Abstract: A composition for producing a glass fiber, including the following components with the corresponding percentage amounts by weight: SiO2: 58-62%; Al2O3: 14-18%; CaO+MgO: 20-24.5%; CaO: greater than 14%; Li2O: 0.01-0.5%; Na2O+K2O: less than 2%; TiO2: less than 3.5%; Fe2O3: less than 1%; and F2: less than 1%. The weight percentage ratio of CaO/MgO is greater than 2 and less than or equal to 2.6; and the weight percentage ratio SiO2/CaO is between 3.3 and 4.3. The invention also provides a glass fiber produced using the composition and a composite material including the glass fiber.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: January 29, 2019
    Assignee: JUSHI GROUP CO., LTD.
    Inventors: Lin Zhang, Guorong Cao, Wenzhong Xing, Guijiang Gu
  • Patent number: 10189743
    Abstract: Apparatus, systems and methods for improving strength of a thin glass member for an electronic device are disclosed. In one embodiment, the glass member can have improved strength by using multi-bath chemical processing. The multi-bath chemical processing allows greater levels of strengthening to be achieved for glass member. In one embodiment, the glass member can pertain to a glass cover for a housing of an electronic device.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: January 29, 2019
    Assignee: APPLE INC.
    Inventors: Stephen Paul Zadesky, Christopher Prest, Douglas Weber
  • Patent number: 10189744
    Abstract: Described is the use of a hardening composition for epoxide-amine-based, multicomponent mortar compositions, particularly the use of one of these epoxide-amine-based, multicomponent mortar compositions for chemical fastening purposes. The multicomponent mortar composition contains (A) a resin component, which comprises as a curable compound at least an epoxide resin and optionally at least one reactive diluent, and (B) a hardener component, which comprises a hybrid hardener, wherein the resin component (A) and/or the hardener component (B) optionally comprises other ingredients selected from among inorganic and/or organic compounds. The hybrid hardener is a mixture of (a) at least one amine, selected from among aliphatic, alicyclic, or aromatic amines, as a hardener, and (b) a novolac resin as catalyst, wherein the novolac resin is contained in a quantity of 30 to 45 percent by weight, relative to the total weight of the hybrid hardener.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: January 29, 2019
    Assignee: Hilti Aktiengesellschaft
    Inventors: Alex Dureault, Stephen Jewitt, Christian Kloninger
  • Patent number: 10189745
    Abstract: Provided are a corrosion-resistant member and an electrostatic chuck device using the same, in which corrosion resistance to halogen corrosive gas such as fluorine corrosive gas or chlorine corrosive gas and plasma thereof is high, dielectric constant and volume resistivity are high, and dielectric loss is low. The corrosion-resistant member is formed of a composite oxide sintered compact containing aluminum, samarium, and a rare earth metal element other than samarium, in which the rare earth metal element other than samarium has an ionic radius of 0.88×10?10 m or more.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: January 29, 2019
    Assignee: SUMITOMO OSAKA CEMENT CO., LTD.
    Inventors: Kentaro Takahashi, Yoshiaki Moriya, Megumi Ootomo
  • Patent number: 10189746
    Abstract: A ceramic composite can include a first ceramic phase and a second ceramic phase. The first ceramic phase can include a silicon carbide. The second phase can include a boron carbide. In an embodiment, the silicon carbide in the first ceramic phase can have a grain size in a range of 0.8 to 200 microns. The first phase, the second phase, or both can further include a carbon. In another embodiment, at least one of the first ceramic phase and the second ceramic phase can have a median minimum width of at least 5 microns.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: January 29, 2019
    Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.
    Inventors: Diana R. Tierney, Matthew Creedon, Tom J. Trunzo, Kenneth R. Delahunty
  • Patent number: 10189747
    Abstract: Particles of a refractory metal or a refractory-metal compound capable of decomposing or reacting into refractory-metal nanoparticles, elemental silicon, and an organic compound having a char yield of at least 60% by weight are combined to form a precursor mixture. The mixture is heating, forming a thermoset and/or metal nanoparticles. Further heating form a composition having nanoparticles of a refractory-metal silicide and a carbonaceous matrix. The composition is not in the form of a powder.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: January 29, 2019
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Teddy M. Keller, Matthew Laskoski
  • Patent number: 10189748
    Abstract: A heat moldable composition which useful for preparing ceramic bodies comprises an inorganic material that sets as a result of baking or sintering, and a hydroxypropyl methylcellulose having a DS of at least 1.4 and an MS of at least 0.6, wherein DS is the degree of substitution of methoxyl groups and MS is the molar substitution of hydroxypropoxyl groups, and a viscosity of up to 80 mPa·s, determined as a 2% by weight solution in water at 20° C., wherein the heat moldable composition comprises at least 40 weight percent of the inorganic material and at least 10 weight percent of the hydroxypropyl methylcellulose, and wherein the composition does not comprise more than 5 weight percent of water, all percentages being based on the total weight of the composition.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 29, 2019
    Assignee: DOW GLOBAL TECHNOLOGIES LLC
    Inventors: Roland Bayer, Anette Wagner
  • Patent number: 10189749
    Abstract: The disclosed invention relates to novel fertilizing compounds comprising a combination of inorganic fertilizers and humic compounds. The combination produces a marked benefit over either type of substance individually, and also over previously known combinations of organic and inorganic fertilizers. The invention also relates to a method of production of such compounds.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: January 29, 2019
    Assignee: Innovative Crop Solutions, Inc.
    Inventors: Dan Kluesner, Darrin Redmond
  • Patent number: 10189750
    Abstract: Aspects of the invention include compositions for fertilizing and remediating soil. Compositions according to certain embodiments include a cellulose nutrient composition, a microbial blend composition, a source of nitrogen, a source of phosphorus and exotic micronutrients. Methods for using compositions of the invention to fertilize and remediate soil and kits having one or more compositions for fertilizing and remediating soil are also described.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: January 29, 2019
    Inventor: Thomas T. Yamashita
  • Patent number: 10189751
    Abstract: Disclosed herein are fluid ionized compositions, such as fluid calcium cyanamide fertilizer compositions, methods of preparation and uses thereof. In some examples, a fluid composition includes a mixture of about 40 to 20 parts of dissolved acid or acid-formed approximately neutral pH nitrogen plant nutrient compounds (such as urea ammonium nitrate and H2O) and about 1 to about 5 parts of a mixture of insoluble or weakly soluble high pH calcium-formed plant nutrient compounds (such as calcium cyanamide and H2O). The disclosed compositions and methods stabilize the compositions' contained active nutrient ions and digested carbon. The disclosed compositions and methods facilitate controllable site-directed delivery of the contents of the compositions. The compositions and methods are effective for microbes nourishment plant fertilizing, soil amending, heavy metals leaching inhibition, and digesting organic proteinaceous excreta.
    Type: Grant
    Filed: May 3, 2016
    Date of Patent: January 29, 2019
    Assignee: BI-EN CORP.
    Inventor: Richard O. Hartmann
  • Patent number: 10189752
    Abstract: Moisture barrier coatings and sealants comprised of mixtures of organic wax and wax soluble polymer dispersed into one or more components of a thermoset polymer which may form a semi-interpenetrating polymer network when the thermoset polymer is subsequently cured on the substrate. The organic wax and wax soluble polymer substantially improve the moisture barrier properties of the thermoset polymer and provides an effective moisture barrier coating that is non-tacky at the cure temperature of the thermoset polymer, without the requirement for a cooling step.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: January 29, 2019
    Assignee: SURFACE CHEMISTS OF FLORIDA, INC.
    Inventors: Felix Achille, Victor Granquist, A. Jaeton Glover, Alice Hudson
  • Patent number: 10189753
    Abstract: The present invention relates to a fog-generating device comprising a reagent (1), ignition means (2), a reservoir (3) containing a fog-generating material (4), and a heat exchanger wherein gas generated by ignition of the reagent (1) drives fog-generating material from said reservoir to said heat exchanger. Further it relates to a removable housing for a fog-generating device comprising a reagent and a reservoir containing a fog-generating material, wherein in that said removable housing further comprises means to allow transmission of an ignition signal from said fog-generating device to said reagent. The invention further provides the use of said device and/or removable housing for the generation of fog, in particular to protect against intruders and physical treat by persons. In a particular embodiment, the fog-generating device of the present invention or the removable housing therefore comprises depressurizing means (18).
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: January 29, 2019
    Assignee: Bandit NV
    Inventor: Alfons Vandoninck
  • Patent number: 10189754
    Abstract: A butadiene production system and a butadiene production method are provided in which butadiene can be produced with a high yield. The butadiene production system (1) includes: a gas preparation device (10) that heats raw materials to prepare a mixed gas including hydrogen and carbon monoxide; an ethanol production device (12) that is provided downstream of the gas preparation device (10) and brings the mixed gas including hydrogen and carbon monoxide into contact with a first catalyst to obtain ethanol; a butadiene production device (16) that is provided downstream of the ethanol production device (12) and brings the ethanol into contact with a second catalyst to obtain butadiene; and return means (18) for returning hydrogen, which is produced as a by-product in the butadiene production device (16), to the ethanol production device (12). In addition, in the butadiene production method, the butadiene production system (1) is used.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: January 29, 2019
    Assignee: SEKISUI CHEMICAL CO., LTD.
    Inventor: Satoshi Koma
  • Patent number: 10189755
    Abstract: The disclosure describes the oligomerization of supercritical ethene. An essential aspect of the invention is that of mixing ethene with an inert medium and setting the conditions in the reaction such that both ethene and the inert medium are supercritical. This is because the solubility for ethene in the inert medium is greater in the supercritical state, such that more ethene is dissolved in the supercritical inert medium than in a liquid solvent. The process regime in the supercritical state therefore enables the use of a much higher proportion of ethene in a homogeneous mixture of ethene and inert medium than is possible on the basis of the thermodynamic solubility restriction in a purely liquid hydrocarbon stream. In this way, the space-time yield is distinctly enhanced. Since a greater amount of ethene can be passed into the reactor, it is possible as a result to better exploit the apparatus volume compared to a liquid phase process. The inert medium used may, for example, be isobutane.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: January 29, 2019
    Assignee: Evonik Degussa GmbH
    Inventors: Helene Reeker, Guido Stochniol, Dietrich Maschmeyer, Stephan Peitz, Jörg Schallenberg
  • Patent number: 10189756
    Abstract: The present invention provides adiabatic plug flow reactors suitable for the production of chlorinated and/or fluorinated propene and higher alkenes from the reaction of chlorinated and/or fluorinated alkanes and chlorinated and/or fluorinated alkenes. The reactors comprise one or more designs that minimize the production of by-products at a desired conversion.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: January 29, 2019
    Assignee: BLUE CUBE IP LLC
    Inventors: Max M. Tirtowidjojo, Hua Bai, Debashis Chakraborty, Juergen Eiffler, Heinz Groenewald, Kurt F. Hirsekorn, Manfred Kokott, William J. Kruper, Thomas U. Luebbe, Thomas J. Parsons, Avani Maulik Patel, Marcus Wobser
  • Patent number: 10189757
    Abstract: A chromia-based fluorination catalyst comprising at least one additional metal selected from zinc, nickel, aluminum and magnesium in which from 0.1 to 8.0% by weight of the catalyst is in the form of one or more crystalline compounds of chromium and/or one or more crystalline compounds of the at least one additional metal. The catalyst can be used in processes for producing a fluorinated hydrocarbon.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: January 29, 2019
    Assignee: Mexichem Amanco Holding S.A. de C.V.
    Inventors: Andrew P Sharratt, John D Scott
  • Patent number: 10189758
    Abstract: To provide a method for producing a hydrofluoroolefin, wherein formation of an over-reduced product having hydrogen added to an aimed hydrofluorolefin and an over-reduced product having some of fluorine atoms in the aimed product replaced with hydrogen atoms, as by-products, is suppressed. A method for producing a hydrofluoroolefin, which comprises reacting a specific chlorofluoroolefin with hydrogen in the presence of a catalyst supported on a carrier, to obtain a specific hydrofluoroolefin, wherein the catalyst is a catalyst composed of particles of an alloy containing at least one platinum group metal selected from the group consisting of palladium and platinum, and gold, and the proportion of the gold at the surface of the alloy particles is from 5 to 30 mass % per 100 mass % in total of the platinum group metal and the gold at the surface of the alloy particles.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: January 29, 2019
    Assignee: AGC Inc.
    Inventors: Xu Wang, Shinji Terazono, Yuki Hayasaka, Toshio Suzuki, Satoshi Kawaguchi, Mitsugu Kasagawa
  • Patent number: 10189759
    Abstract: Disclosed is a process for preparing a chlorinated alkene, comprising contacting a chlorinated alkane with a catalyst in a dehydrochlorination zone to produce a liquid reaction mixture comprising the chlorinated alkane and the chlorinated alkene, and extracting chlorinated alkene from the reaction mixture, wherein the concentration of the chlorinated alkene in the reaction mixture present in the dehydrochlorination zone is controlled such that the molar ratio of chlorinated alkene:chlorinated alkane is from 1:99 to 50:50.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: January 29, 2019
    Assignee: SPOLEK PRO CHEMICKOU A HUNTI VYROBU A.S.
    Inventors: Zdenek Ondrus, Pavel Kubicek, Karel Filas, Petr Sladek
  • Patent number: 10189760
    Abstract: Disclosed is a method for synthesizing a sitagliptin intermediate, the method comprising: in the presence of hydrogen and a transition metal catalyst having a chiral phosphine ligand, subjecting a compound of formula II to an asymmetric reductive amination with ammonia or ammonium salt in a proper organic solvent under the condition of adding an acidic additive to produce a compound of formula I, wherein, an R- or S-configuration of a stereocenter is represented by *; the compound of formula I of R configuration can be used to prepare sitagliptin, and a reaction formula is as follows: R1 and R2 are each independently selected from hydrogen, C1-C12 linear or branched alkyl, C3-C12 cycloalkyl, C2-C12 alkenyl, C2-C12 alkynyl and C7-C12 arylalkyl. The method has a high yield and a high ee % value, a mild reaction condition and a low production cost, and is simple to operate, convenient to purify, environmental friendly and suitable for industrial production.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: January 29, 2019
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., SHANGHAI SYNCORES TECHNOLOGIES INC. LTD.
    Inventors: Jian Hong, Yusheng Wang, Boyu Wang, Luning Huang, Eric Gu
  • Patent number: 10189761
    Abstract: A method for preparation of polyols from an unsaturated TAG oil that involves first epoxidizing the unsaturated TAG oil; then subjecting the epoxidized TAG oil to transesterification using a diol and/or triol in the presence of a catalyst to produce hydroxyalkyl esters of fatty acid epoxides; and finally hydroxylating the transesterification product using a diol and/or triol and a solid acid catalyst to obtain a polyol with relatively high hydroxyl value and low viscosity.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: January 29, 2019
    Inventors: Jonathan M. Curtis, Tolibjon S. Omonov, Ereddad Kharraz, Xiaohua Kong, Hossein M. Tavassoli-Kafrani
  • Patent number: 10189762
    Abstract: Disclosed is a method for purification and separation of cannabinoids, specifically cannabidiol and tetrahydrocannabinol, from the dried hemp and cannabis leaves using a combination of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, a continuous simulated moving bed process, polishing, and crystallization to separate cannabinoids from tetrahydrocannabinol and to provide phytocannabinoid rich oil and cannabidiol isolate. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: January 29, 2019
    Assignee: Orochem Technologies, Inc.
    Inventors: Anil Rajaram Oroskar, David W. House, Praneeth Dayanthe Edirisinghe, Asha Anil Oroskar, Faridedin Adel, Xinjie Chen, Gautham Anil Oroskar
  • Patent number: 10189763
    Abstract: Herein disclosed is a method of reducing greenhouse gas (GHG) emission comprising introducing one or more feed streams into a reformer to generate synthesis gas; and converting synthesis gas to dimethyl ether (DME). In some cases, the reformer is a fluidized bed dry reforming reactor. In some cases, the reformer comprises a hydrogen membrane. In some cases, the hydrogen membrane removes hydrogen contained in the synthesis gas and shifts reforming reactions toward completion.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: January 29, 2019
    Assignee: RES USA, LLC
    Inventors: Harold A. Wright, Mark K. Robertson, Weibin Jiang
  • Patent number: 10189764
    Abstract: The present disclosure relates to methods, processes, and systems for utilizing the dehydrogenation of 2-butanol for hydrogen consuming reactions of biomass or biomass-derived molecules.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: January 29, 2019
    Assignee: VIRDIA, INC.
    Inventors: Robert Jansen, Noa Lapidot, James Alan Lawson, Michael Zviely, Neta Matis, Lee Madsen, Bassem Hallac, Philip Travisano
  • Patent number: 10189765
    Abstract: The present invention relates to a new process for the synthesis of 17?-hydroxy-des-A-androst-9,10-en-5-one, the compound of the following formula (1), which can be used as an intermediate in the synthesis of retroprogesterones.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: January 29, 2019
    Assignee: INDUSTRIALE CHIMICA S.R.L.
    Inventors: Roberto Lenna, Roberto Di Brisco
  • Patent number: 10189766
    Abstract: A process for producing 2-ethylhexanal involves performing reaction using a reaction tank equipped with a gas-introducing mixer having extracting, exhausting, and stirring functions in the presence of a palladium on carbon catalyst having a carbon carrier with lower impurity content and higher specific surface area for hydrogenation, and introducing hydrogen gas evenly into reaction liquid; resulted in that the process minimizes operational pressure for hydrogenation and increases a yield of 2-ethylhexanal at least up to 98.0%.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: January 29, 2019
    Assignee: NAN YA PLASTICS CORPORATION
    Inventors: Te-Chao Liao, Jung-Jen Chuang, Chung-Yu Chen, Chia-Ruey Tsai, Sung-Chieh Chao
  • Patent number: 10189767
    Abstract: A process for manufacturing succinic acid as obtained by fermentation is provided including crystallizing the succinic acid from an aqueous solution, separating the crystals from the mother liquor, treating the mother liquor by nanofiltration and recycling the treated mother liquor to the crystallization step. This process exhibits a high yield in terms of succinic acid crystals recovery and allowing to achieve a final product with a low content of saccharides.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: January 29, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Baptiste Boit, Guillaume Fiey, Maarten Job Van De Graaf
  • Patent number: 10189768
    Abstract: The present invention relates to a method for hydrogenolysis of alpha-hydroxy esters or acids, comprising reacting the alpha-hydroxy ester or acid in the presence of a heterogeneous catalyst. The present invention also relates to a method for producing propionic acid ester, and the use of any of the methods for the production of propionic acid esters, such as alkyl propionate.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: January 29, 2019
    Assignee: Danmarks Tekniske Universitet
    Inventors: Shunmugavel Saravanamurugan, Santosh Govind Khokarale, Anders Riisager
  • Patent number: 10189769
    Abstract: The present invention provides one method for the preparation of pharmaceutically acceptable chlorogenic acid, which comprises the following steps: a. Treating the sample aqueous solution; b. Freezing; c. Thawing and filtering; d. Treating the residue organic phase; e. Concentrating and crystallizing; f. Choosing the number of times to repeat steps a-e according to the variability of chlorogenic acid content in samples; g. Drying. If the chlorogenic acid extract is isolated and purified using this method, water-soluble impurities and liposoluble impurities can be well removed, that allows the impurity content of final products has fulfilled the requirements for medicine; meanwhile, the procedures of this method are simple, and organic solvents can be recycled for further use, with low cost. This method can be applied for the further isolation and purification of chlorogenic acid extract obtained by various ways, especially for the preparation of pharmaceutically acceptable chlorogenic acid.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: January 29, 2019
    Assignee: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Jie Zhang, Liang Zhang, Wang Huang
  • Patent number: 10189770
    Abstract: The present invention provides a method of producing/purifying highly unsaturated fatty acids and/or derivatives thereof while suppressing deterioration of a silver salt aqueous solution, in production/purification of highly unsaturated fatty acids and/or derivatives thereof using the aqueous solution of silver salt. The present invention also contacts or mixes a mixture having a peroxide value (POV) of 10 or smaller with an aqueous solution of silver salt, in a method of purifying highly unsaturated fatty acids and/or derivatives thereof from a mixture comprising highly unsaturated fatty acids and/or derivatives thereof.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: January 29, 2019
    Assignee: Bizen Chemical Co., Ltd.
    Inventors: Mitsumasa Mankura, Yoshihisa Misawa, Yoshio Shimizu
  • Patent number: 10189771
    Abstract: Protected photocrosslinkers and their use in two-stage photocuring of (meth)acrylate monomers is described.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: January 29, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Karl E. Benson, Ross E. Behling, Anish Kurian, Ryan B. Prince, Joshua R. Wurst, Adam R. Wohl, Robert J. Webb, Sehban Ozair
  • Patent number: 10189772
    Abstract: Mixtures comprise (A) 90 to 99.9% by weight of a mixture of L- and D-enantiomers of methyl glycine diacetic acid (MGDA) or its respective mono-, di- or trialkali metal or mono-, di- or triammonium salts, said mixture containing predominantly the respective L-enantiomer with an enantiomeric excess (ee) in the range of from 10 to 99%, and (B) in total 0.1 to 10% by weight of the diacetic acid derivative of at least one amino acid selected from valine, leucine, isoleucine, and tyrosine, as free acids or respective mono-, di- or trialkali metal or mono-, di- or triammonium salts, percentages referring to the sum from (A) and (B).
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: January 29, 2019
    Assignee: BASF SE
    Inventors: Constanze Franzke, Frank Jaekel, Carsten Sueling
  • Patent number: 10189773
    Abstract: Provided herein are in vivo gelling pharmaceutical pre-formulations forming biocompatible hydrogel polymers that are polymerized in vivo and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: January 29, 2019
    Assignee: MEDICUS BIOSCIENCES, LLC
    Inventors: Syed H. Askari, George Horng
  • Patent number: 10189774
    Abstract: The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of mustards and mustard-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: January 29, 2019
    Assignee: Techfields Pharma Co., Ltd.
    Inventors: Chongxi Yu, Lina Xu
  • Patent number: 10189775
    Abstract: The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (ROR?t). These compounds prevent, inhibit, or suppress the action of ROR?t and are therefore useful in the treatment of ROR?t mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 29, 2019
    Assignee: GLENMARK PHARMACEUTICALS S.A.
    Inventors: Sanjib Das, Laxmikant A. Gharat, Rajendra L. Harde, Dnyaneshwar E. Shelke, Shailesh R. Pardeshi, Abraham Thomas, Neelima Khairatkar-Joshi, Daisy M. Shah, Malini Bajpai
  • Patent number: 10189776
    Abstract: The invention relates to a method for the stereoselective preparation of compounds of formula (IV).
    Type: Grant
    Filed: September 16, 2016
    Date of Patent: January 29, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Uwe Joerg Ries, Nizar Haddad, Bo Qu
  • Patent number: 10189777
    Abstract: The invention provides benzenesulfonamido and related compounds, pharmaceutical compositions, methods of promoting ROR? activity, increasing the amount of IL-17 in a subject, and treating cancer using such benzenesulfonamido and related compounds.
    Type: Grant
    Filed: May 5, 2015
    Date of Patent: January 29, 2019
    Assignee: Lycera Corporation
    Inventors: Thomas D. Aicher, Donald J. Skalitzky, Clarke B. Taylor, Chad A. Van Huis
  • Patent number: 10189778
    Abstract: A process for the preparation of methionine a-hydroxy analogue and derivatives thereof comprising contacting one or more sugars or derivatives thereof with a metallo-silicate composition in the presence of a compound comprising sulphur and a solvent.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: January 29, 2019
    Assignee: Haldor Topsoe A/S
    Inventors: Irantzu Sadaba Zubiri, Esben Taarning, Despina Tzoulaki
  • Patent number: 10189779
    Abstract: The present invention discloses processes for producing a thiol compound or a sulfide compound from an olefin compound. Diphenylamine or a phenol compound can be used to increase the rate of conversion of the olefin compound to the thiol compound or the sulfide compound.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: January 29, 2019
    Assignee: Chevron Phillips Chemical Company, LP
    Inventor: Kenneth M. Lassen
  • Patent number: 10189780
    Abstract: Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: January 29, 2019
    Assignee: Zeno Royalties & Milestones, LLC
    Inventor: Kevin Duane Bunker
  • Patent number: 10189781
    Abstract: The onium salt of the present invention contains predetermined compound A represented by the general formula (1). The composition of the present invention contains the onium salt of the present invention, and an onium salt containing predetermined compound B represented by the general formula (2). The onium salt and the composition of the present invention exert well-balanced excellent physical properties in terms of cold curing properties, storage stability, thermal shock resistance after curing, and moisture resistance.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: January 29, 2019
    Assignee: ASAHI KASEI E-MATERIALS CORPORATION
    Inventors: Tadashi Shimura, Naoya Kamimura, Akira Otani, Hitoshi Shimada
  • Patent number: 10189782
    Abstract: The present invention relates to a new class of indole derivatives, having a particular MKlp2 inhibition profile and useful as a therapeutic agent, in particular for the treatment of cancer, viral infections and lung diseases.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: January 29, 2019
    Assignees: BIOKINESIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Cecile Bougeret, Catherine Guillou, Julien Rouleau, Julie Rivollier, Denis Carniato
  • Patent number: 10189783
    Abstract: The present invention relates to a an imide compound according to anyone of formulas Ia, Ib, Ic, or Ie wherein R1 is H or a C1-C20 optionally substituted hydrocarbon group; both R2 and R5 are a COOH group or one of R2 and R5 is a COOH group while the other substituent is H, methyl or ethyl group; R3 and R4 are independently H, or C1-C20 optionally substituted hydrocarbon group; R6 is H or a methyl group; R7 and R8 are independently H, methyl or ethyl.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 29, 2019
    Assignee: DSM IP ASSETS B.V.
    Inventors: Cornelis Eme Koning, Paulus Franciscus Anna Buijsen, Adrianus Jozephus Hendricus Lansbergen, Alwin Papegaaij, Douglas Hayden
  • Patent number: 10189784
    Abstract: Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are N-alkylated D-galacto, D-gluco- or L-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“X”) on the methyloxy-carbon. These compounds display an increased inhibitory potency towards GCS, and/or an increased inhibitory potency towards GBA2, and/or a decreased inhibitory potency towards GBA1, relative to known deoxynojirimycin derivatives of the same (D-gluco, L-ido or D-galacto) configuration.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: January 29, 2019
    Assignees: ACADEMISCH MEDISCH CENTRUM, UNIVERSITEIT LEIDEN
    Inventors: Herman Steven Overkleeft, Stan Van Boeckel, Johannes Maria Franciscus Gerardus Aerts, Amar Ghisaidoobe, Richard Van Den Berg
  • Patent number: 10189785
    Abstract: The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: January 29, 2019
    Assignee: Takeda Pharmaceuticals Company Limited
    Inventors: Yasutomi Asano, Takuto Kojima, Osamu Kurasawa, Tzu-Tshin Wong, Yasuhiro Hirata, Naoki Iwamura, Bunnai Saito, Yuta Tanaka, Ryosuke Arai, Shinichi Imamura, Kazuko Yonemori, Yasufumi Miyamoto, Shuji Kitamura, Osamu Sano
  • Patent number: 10189786
    Abstract: Disclosed are compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, Y, Z, X, R12, R17, R18, R19, Y1, Z1, X1, and X2 are defined herein. These compounds are useful for treating Gram-negative bacteria infections, such as Neisseria gonorrhoeae bacterial infections.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: January 29, 2019
    Assignees: DUKE UNIVERSITY, UNIVERSITY OF NORTH CAROLINA
    Inventors: Pei Zhou, Eric J. Toone, Robert A. Nicholas
  • Patent number: 10189787
    Abstract: The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: January 29, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Marc Labelle, Thomas Boesen, Mukund Mehrotra, Qasim Khan, Farman Ullah