Abstract: The invention provides for remote patient management system comprising a computing device comprising a processor. The computing device further comprises a computer-readable storage medium containing instructions that when executed cause the processor to perform a method of calculating an assessment score. The assessment score measures the effect of a content element on a patient. The method comprising the steps of: delivering the content element to the patient, wherein the content element comprises a list of assessment parameters; generating an assessment content element using the list of assessment parameters; delivering the assessment content element to the patient; receiving a response from patient; and calculating the assessment score using the response.

Abstract: A method for visualizing branches of a lumen includes inserting (402) a fiber optic shape sensing device into a lumen and determining (404) changes in the lumen based upon strain induced in the fiber optic shape sensing device by flow in the lumen. Locations of branches are indicated (410) on a rendering of the lumen. An instrument is guided (414) to the locations of branches indicated on the rendering.

Abstract: Disclosed is a device (1) for processing and transmitting measured signals which correspond to implant parameters or biological parameters for monitoring and/or controlling medical implants, diagnostic devices or biological processes comprising: A) a biocompatible sterilizable covering (9); B) an electronic signal processing device (2) arranged in said covering (9) and electrically connectable to at least one sensor (5) allowing to process measured signals received from said at least one sensor (5); C) a data memory (16) arranged in said covering (9) and electrically connected to said signal processing device (2) allowing to store data received from said signal processing device (2); and D) a data transmission device (4) arranged in said covering (9) and electrically connected to said data memory (16) for transmitting data received from said data memory (16) to a remote data receiving device (6) which is connectable to an external data processing device (8), wherein E) said signal processing device (2) is pro

Abstract: A control apparatus includes a data acquiring unit configured to acquire a measured signal obtained by measuring light emitted from a test object onto which light is irradiated, a processing unit configured to calculate an objective function that varies in accordance with a statistical value obtained by statistically processing the measured signal, and a controller configured to control a modulation amount of a wavefront of the light irradiated onto the test object so as to minimize the objective function.

Abstract: A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to assess the functional status of the tissue, and to identify the existence and severity of disease states. Such assessment can be made by comparing a fluorescence anisotropy profile with a known profile of a control.

Abstract: The present invention pertains to a method and an apparatus for Raman spectroscopy of human tissue. Human tissue is illuminated with a laser emitting a first wavelength of light. A Raman signal is measured and optical properties are determined at this wavelength such that the measured Raman signal can be corrected based on determined optical properties. Determined optical properties may be the scattering coefficient and absorption coefficient of the tissue. A system for Raman spectroscopy of human tissue includes a frequency sweeping laser light source for illumination, and a filtered detector for collecting the Raman signal.

Abstract: A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation circuit. In some aspects, the processed signals are fed into zero crossing detectors that in turn feed a time-to-digital converter providing at an output thereof a digital measure of the phase delay of the received optical signal.

Abstract: A body surface thermometer and a wearable temperature measuring device are disclosed. The body surface thermometer includes an infrared temperature sensor and a shielding protective hood disposed outside the infrared temperature sensor, and the shielding protective hood is an infrared ray shielding protective hood. With the body surface thermometer, the measuring precision of surface temperature of a target object can be promoted, thereby raising the freedom degree of test.

Abstract: Wearable devices are described herein including at least two sensors configured to detect hemodynamic properties of a wearer. A first sensor is configured to detect a hemodynamic property of a portion of vasculature, where the operation of the first sensor is based on a hemodynamic property detected by a second sensor. A timing of operation, a value of one or more controlled operational parameters, a filter setting, or some other aspect of the operation of the first sensor could be controlled based on the hemodynamic property detected by the second sensor. Hemodynamic properties could include blood flow rate, volume, and/or pressure in one or more portions of vasculature, a timing, rate, delay, or other information about heartbeats, an oxygenation level of blood, a velocity of blood cells in blood, or some other information about a wearer's blood, heart, and/or cardiovascular system.

Abstract: Devices and systems are provided to electrically and optically detect hemodynamic properties of a body. Such devices are configured to detect electrocardiographic signals and photoplethysmographic signals and to operate a single analog-to-digital converter (ADC) to sample one or more of each of such signals. This includes operating a multiplexer to connect electrical signals related to the detected optical and electrical properties to the single ADC during respective different sampling times or periods. This can include connecting the detected electrocardiographic signals and photoplethysmographic signals to the ADC during alternating periods of time. Using a single ADC to sample one or more of each of electrocardiographic signals and photoplethysmographic signals can provide samples of such signals that have a relative timing that is known, stable, and controllable.

Abstract: Apparatus for monitoring a clinical condition of a subject is described. At least one motion sensor detects motion of the subject and generates a sensed motion signal responsive to the sensed motion. A signal analyzer is adapted to determine a heartbeat-related signal from the sensed motion signal, to determine a first breathing-rate-related signal from the heartbeat-related signal, and to determine a second breathing-rate-related signal directly from the sensed motion signal. The signal analyzer determines the validity of the heartbeat-related signal by comparing the first breathing-rate-related signal with the second breathing-rate-related signal. Other applications are also described.

Abstract: Disclosed are a blood pressure device, etc., that is capable of highly accurate of blood pressure. The blood pressure device (101) has a blood pressure unit (102) that: finds a specific blood pressure related to pulse wave information (2002), by browsing blood pressure information (2001) associating the pulse wave information and blood pressure related to pulse wave signals caused by blood pressure during a specific period and measured, the pulse wave information associating blood pressure during the specific period and the pulse wave signals; and estimates the blood pressure relating to the pulse wave information (2002) on the basis of the found specific blood pressure.

Abstract: A processing system received data from a Fractional Flow Reserve device and communicates data to a conventional hemodynamic monitoring system having pressure displays. The processing system receives proximal pressure measurement signal from an aortic pressure measurement device and a distal pressure measurement signal from a distal pressure measurement device. A processor computes an FFR ratio from the proximal pressure measurement signal and the distal pressure measurement signal, and converts FFR ratio to a pressure format such that the FFR ratio reads on the conventional hemodynamic monitoring system as a pressure in units of pressure. The processing system transmits the proximal pressure measurement signal, the distal pressure measurement signal, and the FFR ratio in pressure format to the conventional hemodynamic monitoring system.

Abstract: Systems, devices and methods that can be used to obtain objective pressure measurements in a body cavity using one or more monitoring bladders mounted on a catheter. The monitoring bladders may be adapted to connect or be connected to a system capable of providing objective pressure measurements indicative of the compressive forces acting on the one or more monitoring bladder in the body cavity. The body cavity may include, for example, the rectum, esophagus, stomach, intestine, colon, reproductive tract, urethra, oronasopharnygeal tract, etc.

Abstract: Presented herein are substantially automated techniques that enable an electro-acoustic or other hearing prosthesis implanted in a recipient to use objective measurements to determine when the recipient is likely experiencing sound perception changes. Once one or more perception changes are detected, the hearing prosthesis may initiate one or more remedial actions to, for example, address the perception changes. As described further below, the one or more remedial actions may include adjustments to the recipient's operational map to reverse the one or more perception changes.

Abstract: An electrocardiogram high pass filter (25) employs a baseline low pass filter (40), a signal delay (44) and a signal extractor (45). In operation, baseline low pass filter (40) includes a finite impulse response filter (41) and an infinite impulse response low pass filter (42) cooperatively low pass filtering a baseline unfiltered electrocardiogram signal (ECGbu) to output a filtered baseline signal (BSEf). Baseline low pass filter (40) further includes a baseline wander estimator (43) dynamically adjusting a corner frequency of baseline low pass filter (40) as a function of an estimation of any baseline wander within the baseline unfiltered electrocardiogram signal (ECGbu).

Abstract: Embodiments of the disclosure include systems and methods for reducing false positives in detection of pauses. For example, embodiments include a sensing component configured to obtain values of a first physiological parameter and determine a cardiac pause based on the values of the first physiological parameter. Furthermore, embodiments include performing a validation check of the determined cardiac pause using at least one of: the values of the first physiological parameter or values of a second physiological parameter.

Abstract: A method of monitoring the cardiac function of a patient includes receiving a position input from a position sensor attached to the patient and classifying the position input into a position class. Cardiac waveform data is received for the patient and then the cardiac waveform data is compared to model waveform parameters for the position class.

Abstract: A catheter with basket-shaped electrode assembly with spines configured for hyper-flexing in a predetermined, predictable manner when a compressive force acts on the assembly from either its distal end or its proximal end. At least one spine has at least one region of greater (or hyper) flexibility that allows the electrode assembly to deform, for example, compress, for absorbing and dampening excessive force that may otherwise cause damage or injury to tissue wall in contact with the assembly, without compromising the structure and stiffness of the remaining regions of the spine, including its distal and proximal regions. The one or more regions of greater flexibility in the spine allow the spine to flex into a generally V-shape configuration or a generally U-shape configuration.

Abstract: This document discusses, among other things, systems and methods to determine amplitude and morphology variations of a first heart sound over a first number of cardiac cycles, and to calculate an atrial fibrillation metric indicative of an atrial fibrillation episode of the heart using the determined amplitude and morphology variations. The systems and methods can determine a variability score using the determined amplitude and morphology variations, and can calculate the atrial fibrillation metric using the variability score.

Abstract: A cardiac rhythm management system senses a cardiac signal indicative of heartbeats and an acoustic signal indicative of heart sounds and detects atrial tachyarrhythmia based on the sensed cardiac and acoustic signals. In various embodiments, the system senses the cardiac and acoustic signals without using an atrial lead, thus allowing for, for example, monitoring atrial fibrillation burden in a heart failure patient who does not wear an implantable device with an atrial lead. In various embodiments, the system detects heartbeats and heart sounds, measures parameters associated with the detected heartbeats and heart sounds, and detects one or more specified types of atrial tachyarrhythmia using the measured parameters. In various embodiments, the measured parameters are selected from heart rate, heart sound amplitude, cycle length variability, and systolic and diastolic intervals.

Abstract: A medical device having automated electrocardiogram (ECG) feature extraction is disclosed. The medical device includes input circuitry configured to receive an ECG signal. Processing circuitry coupled to the input circuitry is configured to identify at least one fiducial point of heartbeat signature of the ECG signal. The processing circuitry is further configured to perform substantially simultaneously both a discrete wavelet transform (DWT) and a curve length transform (CLT) to identify the at least one fiducial point.

Abstract: A system is provided for isolating a hidden waveform representing hidden information from a composite waveform. The system comprises a processor; a memory configured to store instructions executable by the processor; and a comparator. The instructions cause the processor to estimate that portion of a received composite waveform that represents a first signal source and generate a waveform that represents an estimated first signal source. The comparator comprises a first input coupled to receive the composite waveform and a second input coupled to receive the generated waveform from the processor. The comparator is configured to subtract the generated waveform from the composite waveform and output a resulting estimated hidden waveform, representing the hidden information.

Abstract: Electrodes for use in electroencephalographic recording, including consciousness and seizure monitoring applications, have novel features that speed, facilitate or enforce proper placement of the electrodes, including aligning tabs and arrowed aligning juts, color coding, and an insulating bridge between reference and ground electrodes which ensures a safe application distance between the conductive regions of the two electrodes in the event of cardiac defibrillation or to prevent shorting between the adjacent electrodes by preventing the conductive path to be shared. A method of using a set of four such electrodes is also disclosed.

Abstract: A method for using electrical stimulation for cerebral network analysis. A first source localization procedure is performed, including a first source measurement procedure which produces first source measurement data, using the first source measurement data to find a solution to a first ill-posed problem which provides a first estimated location of the source. The body is electrically stimulated by targeting the first estimated location, and a second, fast source measurement procedure producing second source measurement data is performed thereafter while measurable effects of the step of stimulating, on the source, still remain. The second source measurement data are compared with the first source measurement data for assessing an extent to which the first estimated location is correct.

Abstract: Embodiments of the present invention provide methods of detecting disease, methods of treating disease using targeted hyperthermia, methods of treating disease using targeted chemical agents, methods of treating disease comprising accurate measurements of the efficacy of treatments. The effect of nanoparticles on magnetic fields can be used to determine the location of a disease, and a measure of the number of cells characteristic of the disease. This location and measure can be used to guide therapy, and provide information regarding the most effective therapy to be applied. The same nanoparticles can be used to facilitate hyperthermia treatments, and to allow targeted application of chemical therapeutic agents.

Abstract: An electrical capacitance tomography sensor including a sensor having a plurality of electrodes, where each electrode is formed from a plurality of capacitance segments. Each of the capacitance segments of each electrode can be individually addressed to focus the electric field intensity or sensitivity to desired regions of the electrodes and the sensor.

Abstract: An active protective circuit for a measuring amplifier of an electrical impedance tomograph includes a circuit component arrangement including an electrode input and an output and a control input for a control voltage. The output is configured for connection to a measuring amplifier for an electrical impedance tomograph. The circuit component arrangement creates a conductive connection between the electrode input of the circuit component arrangement and the output of the circuit component arrangement when the applied control voltage is within a first voltage range and does not create a conductive connection when the applied control voltage is within a second voltage range. The voltage being applied to the control input is within the second voltage range when a voltage, which is within a cut-off range, is applied to the electrode input. An electrode belt for impedance tomography has the active protective circuits associated with the electrodes.

Abstract: A sensing apparatus for measuring at least one health and fitness parameter includes at least one sensor for detecting at least one health and fitness parameter and outputting a signal representative of the parameter. The sensing apparatus includes a memory for storing data and computer instructions and a communication component configured to transmit data representative of a value associated with the at least one health and fitness parameter. A processor of the sensing apparatus communicates with the at least one sensor, the memory and the communication component. The processor receives output signals from said at least one sensor, calculates at least one health and fitness parameter based on computer instructions stored in the memory. The parameter is formatted in a human interface device (HID) compliant protocol, and provided to the communication component, which transmits the at least one HID compliant health and fitness parameter value to a remote processing device.

Abstract: During operation, a system iteratively captures MR signals of one or more types of nuclei in one or more portions of a biological lifeform based on scanning instructions that correspond to a dynamic scan plan. The MR signals in a given iteration may be associated with voxels having associated sizes at three-dimensional (3D) positions in at least a corresponding portion of the biological lifeform. If the system detects a potential anomaly when analyzing the MR signals from the given iteration, the system dynamically modifies the scan plan based on the detected potential anomaly, a medical history and/or an MR-scan history. Subsequent measurements of MR signals may be associated with the same or different: types of nuclei, portions of the biological lifeform, voxels sizes and/or 3D positions.

Abstract: A method of monitoring a position of a catheter tip relative to a target tissue. The method includes steps of identifying a wall structure in the target tissue; guiding a catheter towards the wall structure; monitoring a location of the catheter; directing a navigator beam towards the wall structure; aligning the navigator beam with the location of the catheter; monitoring a position of the wall structure using the navigator beam; and determining the position of the wall structure relative to the location of the catheter.

Abstract: An apparatus, system and method for determining a position includes a transducer device (102) configured to receive signals from a console (104) and generate images based upon reflected waves. A flexible cable (108) is coupled to the transducer device to provide excitation energy to the transducer device from the console. An optical fiber (110) has a shape and position corresponding to a shape and position of the cable during operation. A plurality of sensors (122) is in optical communication with the optical fiber. The sensors are configured to measure deflections and bending in the optical fiber such that the deflections and bending in the optical fiber are employed to determine positional information about the transducer device.

Abstract: Systems and methods are described for providing power transfer between modular intraluminal devices. A system embodiment includes, but is not limited to, a first intraluminal device and a second intraluminal device; the first intraluminal device including a body structure, a sensor, a processor, a data transmitter, and a wireless energy receiver oriented to wirelessly receive energy originating external to the first intraluminal device to power at least one of the sensor, the processor, or the data transmitter; the second intraluminal device including a second body structure, and an energy storage device configured to wirelessly transfer energy stored in the energy storage device to the wireless energy receiver of the first intraluminal device when the first intraluminal device and the second intraluminal device are positioned within a subject.

Abstract: A method of determining whether a subject is likely to have a condition includes measuring concentration levels of a plurality of target biomarkers in a sample obtained from the subject; comparing the measured concentration levels to respective reference concentration levels; in the event that the measured concentration level of at least one of the target biomarkers is less than its respective reference concentration level, and the measured concentration level of at least one of the target biomarkers is greater than its respective reference concentration level, providing an indication that the subject is likely to have the condition, and otherwise: providing an indication that the subject is unlikely to have the condition.

Abstract: A method and system for sleep apnea detection are disclosed. The method comprises detecting at least one respiratory signal and utilizing a detection algorithm to automatically detect at least one sleep apnea event from the at least one respiratory signal. The system includes a sensor to determine at least one respiratory signal, a processor coupled to the sensor, and a memory device coupled to the processor, wherein the memory device includes a detection algorithm and an application that, when executed by the processor, causes the processor to utilize the detection algorithm to automatically determine at least one sleep apnea event from the at least one respiratory signal.

Abstract: There is provided a method, apparatus, computer program product and wearable device for monitoring volumetric change of a lung during a breathing cycle by using an electronic signal. The method comprises: receiving by a receiver an electronic signal transmitted from a transmitter, wherein at least part of a path of the signal contours at least part of a chest wall of the lung; determining by the receiver measurements of an attribute of the signal received at the beginning and the end of a time interval during the breathing cycle; calculating by a processor a change in length of the signal path during the time interval based on the measurements of the attribute of the signal received at the beginning and the end of the time interval; and calculating by the processor a volumetric change during the time interval based on the change in signal path length.

Abstract: Biometric monitoring devices, including various technologies that may be implemented in such devices, are discussed herein. Additionally, techniques for enhancing GPS speed and distance measurements based on step counts measured by a biometric monitoring device are provided. Such techniques may, in some implementations, involve blending two independently-measured data streams of raw distance traveled—one based on inter-coordinate GPS coordinate distances and one based on step count and stride length—using a Kalman filter to provide an enhanced-accuracy measurement of distance or speed traveled. In some other or additional implementations, distances or speeds calculated based on inter-coordinate GPS coordinate distances may be smoothed with a smoothing constant that is proportional to the variance in measured step count.

Abstract: A portable, wearable multi-component measurement and analysis device can be utilized for collecting and analyzing bio-mechanical and human gait analysis data while performing any physical activity. This device may be constructed with one or more sensors that are placed on the various localities of human body to collect bio-mechanical data. This data may be transmitted over a network to a server, where it is analyzed, and feedback may be provided in real time on the bio-mechanical and gait parameters experienced by the user's body while performing any particular activity. The device further may allow specialists and experts located anywhere in the world to analyze this real time data and give feedback.

Abstract: A lancing device comprises a lancet drive to cause a lancet to effect a puncturing movement, a housing that encloses the lancet drive, and a touching element with an opening for applying a part of a body in which a prick wound is to be produced, the touching element being movable relative to the lancet drive for the purpose of adjusting the puncturing depth in a puncturing direction. The touching element is connected rotatably by means of a screw thread to an intermediate piece and is movable in the puncturing direction, while the intermediate piece is rotatable and movable relative to the housing. A guide prevents rotation of the touching element relative to the housing, and the touching element is enclosed by the intermediate piece at least over part of its length.

Abstract: The invention relates to a method for assessment of a series of glucose concentration values of a body fluid of a diabetic for adjustment of the dosing of insulin administrations as well as a suitable device for carrying out the method.

Abstract: Embodiments of the invention provide analyte sensors having optimized electrodes and/or configurations of electrode elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: Methods, apparatuses, and systems are provided for determining whether to administer a medication dose as a single dose or whether to fractionate the single dose to be administered as at least two discrete doses. Embodiments include determining a first analyte level and a first rate of change of the analyte level; determining an initial medication dose based on one or more anticipated subsequent medication doses, the first analyte level relative to an analyte level threshold, and the first rate of change of the analyte level relative to a rate of change threshold; administering the initial medication dose; determining a second analyte level and a second rate of change of the analyte level based on subsequent analyte data; and determining a subsequent medication dose based on the second analyte level relative to the analyte level threshold and the second rate of change relative to the rate of change threshold.

Abstract: An inserter assembly for continuous glucose monitoring with medication delivery capability where the assembly has a deployment button containing a needle deployment mechanism having a sharp held in a pre-release position, a housing body in which the deployment button is movably received within a top end of the housing body, the housing body having a sensor deployment assembly containing a lumen and a sensor disposed within the lumen and extending out of the lumen to a circuit board that is part of the sensor deployment assembly, the sensor deployment assembly matingly connected to the sharp where the sharp extends beyond the sensor deployment assembly and contains the sensor not fixedly attached to the sharp, and a sensor housing releasably received within a lower end of the housing body, the sharp extending into a sensor deployment assembly recess within the sensor housing and directly above a sensor opening in a bottom of the sensor housing.

Abstract: An inserter assembly for continuous glucose monitoring with medication delivery capability where the assembly has a deployment button containing a needle deployment mechanism having a sharp held in a pre-release position, a housing body in which the deployment button is movably received within a top end of the housing body, the housing body having a sensor deployment assembly containing a lumen and a sensor disposed within the lumen and extending out of the lumen to a circuit board that is part of the sensor deployment assembly, the sensor deployment assembly matingly connected to the sharp where the sharp extends beyond the sensor deployment assembly and contains the sensor not fixedly attached to the sharp, and a sensor housing releasably received within a lower end of the housing body, the sharp extending into a sensor deployment assembly recess within the sensor housing and directly above a sensor opening in a bottom of the sensor housing.

Abstract: Provided are methods and apparatus for receiving sensor data from an analyte sensor of a sensor monitoring system, processing the received sensor data with time corresponding calibration data, outputting the processed sensor data, detecting one or more adverse conditions associated with the sensor monitoring system, disabling the output of the sensor data during the adverse condition time period, determining that the one or more detected adverse conditions is no longer present in the sensor monitoring system, retrieving the sensor data during the adverse condition time period, processing the retrieved sensor data during the adverse condition time period, and outputting the processed retrieved sensor data.

Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values.

Abstract: Methods and apparatus for providing multi-stage signal amplification in a medical telemetry system are provided.

Abstract: An embodiment of the present disclosure seeks to smooth a perfusion index measurement through use of a baseline perfusion index measurement and/or through the use of multiple PI calculations. The combination of the baseline perfusion index measurement reduces an error between a calculated measurement of PI and actual conditions.

Abstract: A sensor cover according to embodiments of the disclosure is capable of being used with a non-invasive physiological sensor, such as a pulse oximetry sensor. Certain embodiments of the sensor cover reduce or eliminate false readings from the sensor when the sensor is not in use, for example, by blocking a light detecting component of a pulse oximeter sensor when the pulse oximeter sensor is active but not in use. Further, embodiments of the sensor cover can prevent damage to the sensor. Additionally, embodiments of the sensor cover prevent contamination of the sensor.

Abstract: A control section performs first preliminary imaging in which an observation target is illuminated with first blue light at a wavelength band of 450±10 nm and an image of the observation target is captured. A yellow pigment concentration calculator calculates concentration of the yellow pigment based on an image signal obtained by performing the first preliminary imaging. A prescribed exposure amount calculator calculates a prescribed exposure amount of second blue light at a wavelength band of 470±10 nm for second preliminary imaging based on the calculated concentration of the yellow pigment. A control section performs second preliminary imaging in which an observation target is illuminated with the second blue light and an image of the observation target is captured based on a prescribed exposure amount of the second blue light for the second preliminary imaging. An arithmetic value calculator calculates an arithmetic value based on an image signal obtained by performing the second preliminary imaging.