Patents Issued in February 7, 2019
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Publication number: 20190039959Abstract: There is provided a shape memory ceramic structure including an aggregate population of crystalline particles. Each crystalline particle in the population, of crystalline particles comprises a shape memory ceramic particle material. Each crystalline particle in the population of crystalline particles has a crystalline particle extent that is between about 0.5 microns and about fifty microns. At least a portion of the population of crystalline particles has a crystalline structure that is either oligocrystalline or monocrystalline.Type: ApplicationFiled: February 10, 2017Publication date: February 7, 2019Applicants: Massachusetts Institute of Technology, Nanyang Technological UniversityInventors: Zehui Du, Hang Yu, Christopher A. Schuh, Chee Lip Gan
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Publication number: 20190039960Abstract: The invention provides novel aerated composite materials that possess excellent physical and performance characteristics of aerated concretes, and methods of production and uses thereof. These composite materials can be readily produced from widely available, low cost raw materials by a process suitable for large-scale production with improved energy consumption, desirable carbon footprint and minimal environmental impact.Type: ApplicationFiled: June 6, 2018Publication date: February 7, 2019Inventors: Omkar DEO, Vahit ATAKAN, Deepak RAVIKUMAR, Xudong HU, Sadananda SAHU, Surojit GUPTA, Richard RIMAN
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Publication number: 20190039961Abstract: The invention relates to a method for producing a ceramic moulded body, comprising the following steps: a) producing a green body containing ceramic material, binding agents and an organic pore forming agent; b) heating the green body to a temperature higher than the sublimation and/or decomposition temperature of the pore forming agent; c) burning the green body to form a ceramic moulded body. According to the invention, the binding agent comprises polyglycols and fumaric acid.Type: ApplicationFiled: February 9, 2017Publication date: February 7, 2019Inventors: Siegbert Christiani, Chriffe Omar Belda, Christian Wenzel
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Publication number: 20190039962Abstract: The present application generally relates to a method for the manufacture of a liquid composition essentially consisting of an organic solvent of the type glycol and a urease inhibitor of the type phosphoric triamide and products obtained therewith.Type: ApplicationFiled: February 24, 2017Publication date: February 7, 2019Applicant: YARA INTERNAL ASAInventors: Filip Colpaert, Francois Ledoux, Ruud Van Belzen
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Publication number: 20190039963Abstract: The present disclosure relates to consortia of bacteria strains and composition comprising one or more bacterial strains disclosed herein. These consortia of isolated bacteria cultures and compositions comprising said cultures, having greater activity than would be observed for the individual bacteria cultures and compositions. A composition of the disclosure may advantageously be used for enhancing the availability of soil phosphorus and other macronutrients and/or micronutrients to plants, and thereby enhancing their growth and yield.Type: ApplicationFiled: August 20, 2018Publication date: February 7, 2019Inventors: Matthew D. Wallenstein, Colin W. Bell
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Publication number: 20190039964Abstract: Methods and systems are provided for generating and utilizing a bacterial composition that comprises at least one genetically engineered bacterial strain that fixes atmospheric nitrogen in an agricultural system that has been fertilized with more than 20 lbs of Nitrogen per acre.Type: ApplicationFiled: October 12, 2018Publication date: February 7, 2019Inventors: Karsten Temme, Alvin Tamsir, Sarah Bloch, Rosemary Clark, Emily Tung, Kevin Hammill, Douglas Higgins, Austin Davis-Richardson
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Publication number: 20190039965Abstract: A fertilizer composition includes a seed particle spray coated with a fertilizer material including a soluble fertilizer and micronized sulphur particles. A method of producing a fertilizer composition includes the steps of producing a seed particle; preparing a sprayable suspension comprising a solution of a fertilizer material in water, a suspended insoluble fertilizer material, and a dispersant; and using the suspension to spray coat a layer of a mixture of the soluble and insoluble fertilizer material onto the seed particle.Type: ApplicationFiled: February 28, 2017Publication date: February 7, 2019Inventors: Satish IYER, Eric PEDERSEN, Richard KNOLL, Babasola AJIBOYE, Mitchel Flegel
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Publication number: 20190039966Abstract: A surfactant-assisted self-assembly method can be used to crystallize energetic materials with controlled morphology. Microparticles of hexanitrohexaazaisowurtzitane (CL-20) formed by this method may have enhanced functional reproducibility due to their monodisperse nature, and decreased shock sensitivity due to their sub-2 ?m particle size.Type: ApplicationFiled: October 12, 2017Publication date: February 7, 2019Inventors: Hongyou Fan, Leanne Julia Alarid, David Rosenberg, Kaifu Bian
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Publication number: 20190039967Abstract: A new, rapid and inexpensive synthesis method for monodispersed triaminotrinitrobenzene (TATB) microparticles based on micelle-confined precipitation that enables control of microscopic morphology. The morphology of the TATB microparticles can be tuned between quasi-spherical and faceted by controlling the speed of recrystallization.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Inventors: Hongyou Fan, Kaifu Bian, David Rosenberg, Leanne Julia Alarid
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Publication number: 20190039968Abstract: A fluidized bed process for producing para-xylene via toluene and/or benzene methylation with methanol using a dual function catalyst system. A first catalyst accomplishes the toluene and/or benzene methylation and a second catalyst converts the by-products of the methylation reaction or unconverted methylating agent, improves the yields of the desired products, or a combination thereof. The inclusion of the second catalyst can suppress the C1-C5 non-aromatic fraction by over 50% and significantly enhance the formation of aromatics.Type: ApplicationFiled: January 27, 2017Publication date: February 7, 2019Inventors: Nikolaos Soultanidis, Todd E. Detjen, Scott J. Weigel
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Publication number: 20190039969Abstract: The present invention relates to an integrated process to convert crude oil into petrochemical products comprising crude oil distillation, aromatic ring opening, and olefins synthesis, which process comprises subjecting a hydrocarbon feed to aromatic ring opening to produce LPG and subjecting the LPG produced in the integrated process to olefins synthesis. Furthermore, the present invention relates to a process installation to convert crude oil into petrochemical products comprising a crude distillation unit comprising an inlet for crude oil and at least one outlet for kerosene and/or gasoil; an aromatic ring opening unit comprising an inlet for a hydrocarbon feed to aromatic ring opening and an outlet for LPG; and a unit for the olefins synthesis comprising an inlet for LPG produced by the integrated petrochemical process installation and an outlet for olefins.Type: ApplicationFiled: October 5, 2018Publication date: February 7, 2019Inventors: Andrew Mark WARD, Ravichander NARAYANASWAMY, Vijayanand RAJAGOPALAN, Arno Johannes Maria OPRINS, Egidius Jacoba Maria SCHAERLAECKENS, Raul VELASCO PELAEZ
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Publication number: 20190039970Abstract: The present invention relates to an integrated process to convert crude oil into petrochemical products comprising crude oil distillation, aromatic ring opening, and olefins synthesis, which process comprises subjecting a hydrocarbon feed to aromatic ring opening to produce LPG and subjecting the LPG produced in the integrated process to olefins synthesis. Furthermore, the present invention relates to a process installation to convert crude oil into petrochemical products comprising a crude distillation unit comprising an inlet for crude oil and at least one outlet for kerosene and/or gasoil; an aromatic ring opening unit comprising an inlet for a hydrocarbon feed to aromatic ring opening and an outlet for LPG; and a unit for the olefins synthesis comprising an inlet for LPG produced by the integrated petrochemical process installation and an outlet for olefins.Type: ApplicationFiled: October 5, 2018Publication date: February 7, 2019Inventors: Andrew Mark WARD, Ravichander NARAYANASWAMY, Vijayanand RAJAGOPALAN, Arno Johannes Maria OPRINS, Egidius Jacoba Maria SCHAERLAECKENS, Raul VELASCO PELAEZ
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Publication number: 20190039971Abstract: The invention relates to a method for producing butadiene from n-butenes having the steps: A) providing an n-butene-comprising feed gas stream a; B) feeding the n-butene-comprising feed gas stream a and an oxygen-comprising gas into at least one oxidative dehydrogenation zone and oxidatively dehydrogenating n-butenes to butadiene, wherein a product gas stream b comprising butadiene, unreacted n-butenes, steam, oxygen, low-boiling hydrocarbons, high-boiling minor components, optionally carbon oxides and optionally inert gases is obtained; Ca) cooling the product gas stream b by contacting it with a refrigerant and condensing at least a part of the high-boiling minor components; Cb) compressing the remaining product gas stream b in at least one compression step, wherein at least one aqueous condensate stream c1 and a gas stream c2 comprising butadiene, n-butenes, steam, oxygen, low-boiling hydrocarbons, optionally carbon oxides and optionally inert gases is obtained; Da) separating off non-condensable and loType: ApplicationFiled: January 30, 2017Publication date: February 7, 2019Inventors: JAN Pablo JOSCH, Ragavendra Prasad BALEGEDDE RAMACHANDRAN, Ulrike WENNING, Anton WELLENHOFER, Christine TOEGEL, Hendrik REYNEKE, Heinz BOELT
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Publication number: 20190039972Abstract: The invention relates to a process for conversion of a stream comprising methane and ethane, comprising converting ethane from a stream comprising methane and ethane, in which stream the volume ratio of methane to ethane is of from 0.005:1 to 100:1, to a product having a vapor pressure at 0° C. lower than 1 atmosphere, resulting in a stream comprising methane and the product having a vapor pressure at 0° C. lower than 1 atmosphere; separating the product having a vapor pressure at 0° C. lower than 1 atmosphere from the stream comprising methane and the product having a vapor pressure at 0° C. lower than 1 atmosphere, resulting in a stream comprising methane; and chemically converting methane from the stream comprising methane, or feeding methane from the stream comprising methane to a network that provides methane as energy source, or liquefying methane from the stream comprising methane.Type: ApplicationFiled: February 2, 2017Publication date: February 7, 2019Inventors: Ronald Jan SCHOONEBEEK, Alouisius Nicolaas Renée BOS, Guus VAN ROSSUM, Michael Johannes Franciscus Maria VERHAAK
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Publication number: 20190039973Abstract: A method of oxidative dehydrogenating a butane-containing hydrocarbon stream by contacting the same with a bimetallic catalyst in the presence of an oxidant, wherein the bimetallic catalyst comprises nickel and bismuth on a titanium carbide catalyst support. Various embodiments of the method of oxidative dehydrogenating the butane-containing hydrocarbon stream and the bimetallic catalyst are also provided.Type: ApplicationFiled: October 11, 2018Publication date: February 7, 2019Applicant: King Fahd University of Petroleum and MineralsInventor: Isam ALJUNDI
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Publication number: 20190039974Abstract: A method may comprise: feeding a backend deethanizer overhead stream comprising ethylene, ethane, and acetylene to a hydrogenation reactor; hydrogenating at least a portion of the acetylene in the backend deethanizer overhead stream to form a reactor effluent stream comprising ethylene, ethane, and green oil; feeding the reactor effluent stream to a gas/liquid coalescer; and removing at least a portion of the green oil from the reactor effluent stream to produce a cleaned effluent stream.Type: ApplicationFiled: August 2, 2018Publication date: February 7, 2019Applicant: Janus Technology Solutions, LLCInventors: Sabah A. Kurukchi, Joseph M. Gondolfe
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Publication number: 20190039975Abstract: The present invention provides a method for producing tetrafluoropropene represented by formula (1) by bringing monochlorotrifluoropropene represented by formula (2) into contact with anhydrous hydrogen fluoride in the presence of a catalyst, the method being capable of maintaining the conversion of the starting material and the selectivity for the target product within an excellent range, while reducing degradation of the catalyst to maintain the reaction for a long time.Type: ApplicationFiled: February 3, 2017Publication date: February 7, 2019Applicant: DAIKIN INDUSTRIES, LTD.Inventors: Shun OHKUBO, Takashi USUI, Takehiro CHAKI, Daisuke KARUBE
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Publication number: 20190039976Abstract: A low-carbon environmentally-friendly foamer composition is disclosed. The composition includes the following ingredients in mass percentage: 60-98.99% of 1-chloro-3,3,3-trifluoropropene, 1-39.9% of 1,1,1,2,3-pentafluoropropane and 0.01-1% of 1,2,2,3-tetrafluoropropane. The GWP value of the low-carbon environmentally-friendly foamer composition is smaller than the GWP value of a single-medium HFC-245fa. This low-carbon environmentally-friendly foamer composition has the features of environmental protection, excellent foaming performance and little modification of foaming devices, and can reduce the heat conductivity coefficient and overall energy consumption level. Therefore, the low-carbon environmentally-friendly foamer composition is the best choice for high-performance hard insulating foam, and is an ideal choice of future foamer.Type: ApplicationFiled: July 21, 2017Publication date: February 7, 2019Applicant: Zhejiang Quhua Fluor-Chemistry Co LtdInventors: Jiangyong HONG, Bo YANG, Yang ZHAO, Yan ZHANG, Huadong ZHOU, Hao OUYANG, Haitao GONG, Min FANG
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Publication number: 20190039977Abstract: Iron-based homogeneous catalysts, supported by pincer ligands, are employed in the transfer hydrogenation of esters using C2-C12 alcohols as sacrificial hydrogen donors to produce corresponding alcohols from the esters. No external H2 pressure is required. The reaction can be carried out under ambient pressure.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Sumit Chakraborty, Vikram Seshadri, Steven J. Adams, Robert Thomas Hembre, Scott Donald Barnicki
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Publication number: 20190039978Abstract: A transfer hydrogenation process for forming vicinal diols by hydrogenating 1,2-dioxygenated organic compounds using alcohols as the reducing agent instead of the traditional H2 gas. The transfer hydrogenation is carried out under milder conditions of temperature and pressure than is typical for ester hydrogenation with H2. The milder conditions of operation provide benefits, such as lower operating and capital costs for industrial scale production as well as savings in product purification due to the avoidance of by-products from exposure of reaction mixtures and products to high temperatures.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Sumit Chakraborty, Robert Thomas Hembre
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Publication number: 20190039979Abstract: The invention provides a process for the production of alkylene glycols, said process comprising providing a feed comprising at least 10 wt % of lignocellulose and/or one or more saccharides, on the basis of the overall feed, in water to a reactor; also providing a feed comprising one or more hydrogen-donating organic solvent species to the reactor; contacting the lignocellulose and/or one or more saccharides in the reactor with a retro-aldol catalyst composition at a temperature in the range of from at least 160 to at most 270° C., wherein the combined solvent system within the reactor comprises in the range of from at least 5 to at most 95 wt % of one or more hydrogen-donating organic solvent species and in the range of from at least 5 to at most 95 wt % of water.Type: ApplicationFiled: February 8, 2017Publication date: February 7, 2019Inventors: Evert VAN DER HEIDE, Pieter HUIZENGA, Dionysius Jacobus Maria DE VLIEGER
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Publication number: 20190039980Abstract: The present invention relates to an improved way for the production of farnesol.Type: ApplicationFiled: September 16, 2016Publication date: February 7, 2019Inventors: Werner BONRATH, Raphael BEUMER, Jonathan Alan MEDLOCK
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Publication number: 20190039981Abstract: Use of diverse biomass feedstock in a process for the recovery of target C5 and C6 alditols and target glycols via staged hydrogenation and hydrogenolysis processes is disclosed. Particular alditols of interest include, but are not limited to, xylitol and sorbitol. Various embodiments of the present invention synergistically improve overall recovery of target alditols and/or glycols from a mixed C5/C6 sugar stream without needlessly driving total recovery of the individual target alditols and/or glycols. The result is a highly efficient, low complexity process having enhanced production flexibility, reduced waste and greater overall yield than conventional processes directed to alditol or glycol production.Type: ApplicationFiled: February 17, 2017Publication date: February 7, 2019Applicant: INTERCONTINENTAL GREAT BRANDS LLCInventors: Lloyd ALLEN, Claudio ARATO, Terry BRIX, Peter Andrew CLARKE, Joshua DAVIES, Bryan GENE, Mark KIRBY, Quak Foo LEE, William MCKEAN, Ankit MUNJAPARA, Clive Richard NORTON, Stuart A. STEIN, Greg STOCK, David SUGDEN
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Publication number: 20190039982Abstract: The disclosure relates to a method of performing ozonolysis or ozone-based oxidation on a liquid or emulsified reagent using a tubular falling firm reactor with one or multiple tubes wherein the combined ozone and carrier gas flow is co-current.Type: ApplicationFiled: August 7, 2018Publication date: February 7, 2019Applicant: P2 Science, Inc.Inventors: Patrick FOLEY, Neil BURNS, Alexandre CHAPEAUX, Icilio ADAMI, Antonio MILICIA
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Publication number: 20190039983Abstract: The present invention relates to a process for the purification of curcumin comprising provision of a curcuminoid composition, contacting said curcuminoid composition with basic amino acid or amino acid ester in order to form an amino acid salt of curcumin, separating the salt of curcumin, and recovering curcumin at increased purity levels. Curcumin may be obtained at purity levels beyond 90 wt. %.Type: ApplicationFiled: March 16, 2017Publication date: February 7, 2019Inventor: Philippe NEVEN
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Publication number: 20190039984Abstract: Disclosed is a process for recovering formic acid from a formate ester of a C3 to C4 alcohol. Disclosed is also a process for producing formic acid by carbonylating a C3 to C4 alcohol, hydrolyzing the formate ester of the alcohol, and recovering a formic acid product. The alcohol may be dried and returned to the reactor. The process enables a more energy efficient production of formic acid than the carbonylation of methanol to produce methyl formate.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Scott Donald Barnicki, Robert Thomas Hembre, Sumit Chakraborty, Gerald Wayne Ollis, Randy Lynn Jennings, Stijn Van de Vyver
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Publication number: 20190039985Abstract: Disclosed is a process for recovering formic acid from a formate ester that allows for recovery of a formic acid product comprising greater than 75 wt. % formic acid. Disclosed is also a process for producing formic acid by carbonylating a carrier alcohol, hydrolyzing the formate ester of the carrier alcohol, and recovering a formic acid product comprising greater than 70 wt. % formic acid. Discloses are carrier alcohols that enable more favorable hydrolysis equilibriums and/or distillation sequences.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Scott Donald Barnicki, Robert Thomas Hembre, Sumit Chakraborty, Vickie Haygood Osborne, Michael Richard Laningham, Stijn Van de Vyver
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Publication number: 20190039986Abstract: A method of producing monochloroacetic acid (MCAA) has been disclosed encompassing (a) a stage of the direct chlorination of acetic acid with chlorine and (b) a stage of recovery of the catalyst in the form of acid chlorides from the reaction mixture before (c) a hydrodehalogenation stage characterized by the fact that the chlorination process (a) is conducted at the boiling temperature of the mixture under a pressure of 0-1.Type: ApplicationFiled: February 4, 2017Publication date: February 7, 2019Inventor: Bartosz Bankowski
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Publication number: 20190039987Abstract: A method for purifying methacrylic acid, including mixing raw material methacrylic acid and methanol; precipitating a crystal of methacrylic acid from the mixed solution; and separating the crystal and mother liquor, wherein the raw material methacrylic acid and methanol are mixed so that a concentration of methanol in the mixed liquid is 3.0 to 3.75% by mass, and the crystal of methacrylic acid is precipitated from the mixed solution in a cooling crystallization vessel.Type: ApplicationFiled: October 9, 2018Publication date: February 7, 2019Applicant: Mitsubishi Chemical CorporationInventors: Koji Kanaya, Tomomichi Hino, Shinpei Kato, Takafumi Toyoda
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Publication number: 20190039988Abstract: Embodiments are directed to adamantane-intercalated layered double-hydroxide (LDH) particles and the methods of producing adamantane-intercalated LDH particles. The adamantane-intercalated LDH particles have a general formula defined by [M1-xAlx(OH)2](A)x.mH2O, where x is from 0.14 to 0.33, m is from 0.33 to 0.50, M is chosen from Mg, Ca, Co, Ni, Cu, or Zn, and A is adamantane carboxylate. The adamantane-intercalated LDH particles further have an aspect ratio greater than 100. The aspect ratio is defined by the width of an adamantane-intercalated LDH particle divided by the thickness of the adamantane-intercalated LDH particle.Type: ApplicationFiled: October 11, 2018Publication date: February 7, 2019Applicants: Saudi Arabian Oil Company, Durahm UniversityInventors: Manohara Gudiyor Veerabhadrappa, Hugh Christopher Greenwell, Gasan Selman Alabedi, John Adrian Hall, Abdullah A. Al-Shahrani, Andrew Whiting
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Publication number: 20190039989Abstract: The present invention relates to a class of fatty acid compounds, a preparation method thereof and use thereof. The fatty acid compounds have the structure of the formula I, which has the ability to activate APMK and inhibit the glucose output in mouse primary hepatocytes. The fatty acid compounds can be used in preparing a medicament for the treatment of obesity or diabetes.Type: ApplicationFiled: February 20, 2017Publication date: February 7, 2019Inventors: Fajun NAN, Jia LI, Jingya LI, Mei ZHANG, Zhifu XIE, Jingtao WANG, Dongdong GUO
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Publication number: 20190039990Abstract: Iron-based homogeneous catalysts, supported by pincer ligands, are employed in the catalytic dehydrocoupling of methanol to produce methyl formate and hydrogen. As both methanol and methyl formate are volatile materials, they can be readily separated from the catalyst by applying vacuum at room temperature. The hydrogen by-product of the reaction may be isolated and utilized as a feedstock in other chemical transformations.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Sumit Chakraborty, Steven J. Adams, Robert Thomas Hembre, Scott Donald Barnicki
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Publication number: 20190039991Abstract: Iron-based homogeneous catalysts, supported by pincer ligands, are employed in the catalytic dehydrocoupling of ethanol to produce ethyl acetate and hydrogen. As both ethanol and ethyl acetate are volatile materials, they can be readily separated from the catalyst by applying vacuum at room temperature. The hydrogen by-product of the reaction may be isolated and utilized as a feedstock in other chemical transformations.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Sumit Chakraborty, Steven J. Adams, Robert Thomas Hembre, Scott Donald Barnicki
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Publication number: 20190039992Abstract: A process for preparing a variety of secondary and tertiary alkyl formate esters via the coupling of methanol and secondary (or tertiary) alcohols. Iron-based catalysts, supported by pincer ligands, are employed to produce these formate esters in high yields and unprecedentedly high selectivities (>99%). Remarkably, the coupling strategy is also applicable to bulkier tertiary alcohols, which afford corresponding tertiary formate esters in moderately high yields and high selectivities.Type: ApplicationFiled: July 24, 2018Publication date: February 7, 2019Applicant: Eastman Chemical CompanyInventors: Sumit Chakraborty, Steven J. Adams, Robert Thomas Hembre, Scott Donald Barnicki, Michael Richard Laningham, Gerarld Wayne Ollis, Randy Lynn Jennings
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Publication number: 20190039993Abstract: The present invention relates to a process to prepare ethylene amines of the formula NH2—(C2H4—NH—)pH wherein p is at least 3 or derivatives thereof wherein one or more units —NH—C2H4—NH— may be present as a cyclic ethylene urea unit or between two units —NH—C2H4—NH— a carbonyl moiety is present, by reacting an ethanolamine-functional compound, an amine-functional compound in the presence of a carbon oxide delivering agent, wherein the molar ratio of carbon oxide delivering agent to amine-functional compound is at least 0.6 to 1.Type: ApplicationFiled: February 10, 2017Publication date: February 7, 2019Inventors: Rolf Krister EDVINSSON, Eike Nicolas KANTZER, Per Fredrik Olmo LARSSON, Karl Fredrik LAKE, Antoon Jacob Berend TEN KATE
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Publication number: 20190039994Abstract: The present invention relates to a process to convert cyclic alkylene ureas into their corresponding alkylene amines wherein the process is performed by reaction with an amine compound, and wherein the amine compound comprises a primary amine, a cyclic secondary amine or a tertiary bicyclic amine.Type: ApplicationFiled: February 10, 2017Publication date: February 7, 2019Inventors: Rolf Krister EDVINSSON, Eike Nicolas KANTZER, Per Fredrik Olmo LARSSON, Karl Fredrik LAKE, Antoon Jacob Berend TEN KATE, Ulf SCHRÖDER, Johan Salman MALMBERG
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Publication number: 20190039995Abstract: The present invention relates to a method for preparing substituted 4-aminoindane derivatives of the general formula (I) by cyclization, in which R, n, R1, R2, R3, R4, Q1 and Q2 have the definitions specified in the description.Type: ApplicationFiled: January 27, 2017Publication date: February 7, 2019Inventors: Christoph SÄMANN, Thomas HIMMLER
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Publication number: 20190039996Abstract: An monoamine compound and an organic electroluminescence device including the monoamine compound, the monoamine compound being represented by the following Formula 1:Type: ApplicationFiled: March 15, 2018Publication date: February 7, 2019Inventors: Ichinori TAKADA, Takuya UNO, Xiulan JIN
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Publication number: 20190039997Abstract: The present invention provides a method of producing an ethanolamine, with a low production ratio of a dialkanolamine (for example, less than 30% by weight). A process for producing an alkanolamine of the present invention includes reacting an alkylene oxide with ammonia to obtain a reaction product containing a monoalkanolamine, a dialkanolamine, and a trialkanolamine; separating the dialkanolamine from the reaction product; and recycling at least a portion of the dialkanolamine for the reaction of an alkylene oxide with ammonia, wherein in the recycling step, the dialkanolamine is supplied in a molar ratio of the alkylene oxide (moles) to a total amount (moles) of ammonia and the dialkanolamine of 0.08 or more and less than 0.26.Type: ApplicationFiled: March 16, 2017Publication date: February 7, 2019Inventors: Daisuke ICHIKAWA, Takahiro SUGIYA
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Publication number: 20190039998Abstract: A monomer represented by Chemical Formula 1: wherein, in Chemical Formula 1, R1, R2, A1, A2, L1, L2, o, p, q, and r are the same as defined in the detailed description.Type: ApplicationFiled: August 2, 2018Publication date: February 7, 2019Inventors: Dmitry ANDROSOV, Hyunseok CHOI, Kalinina FEDOSYA
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Publication number: 20190039999Abstract: A cell seeding plate comprises a substrate and a photolysis layer formed on a surface of the substrate. The photolysis layer comprises a plurality of photolysis groups, and each of the plurality of photolysis groups has a chemical structural formula of R1 and R3 each represents alkane group, R2 comprises alkane group or olefin group, R5, R6 and R7 each represents hydrogen group or alkane group. Each of the plurality of photolysis groups is bonded to the surface by the amide group.Type: ApplicationFiled: August 29, 2017Publication date: February 7, 2019Inventor: HSIU-WEN CHIEN
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Publication number: 20190040000Abstract: This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.Type: ApplicationFiled: October 5, 2018Publication date: February 7, 2019Inventors: Ramesh Narayanan, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Charles B. DUKE, Christopher C. COSS, Amanda JONES, James T. DALTON
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Publication number: 20190040001Abstract: A method for modulating RNA with tetracycline compounds is described.Type: ApplicationFiled: February 20, 2018Publication date: February 7, 2019Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
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Publication number: 20190040002Abstract: A crystalline mono hydrochloride salt of (4S,4aS,5aR, 12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3, 10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1, 4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.Type: ApplicationFiled: March 6, 2018Publication date: February 7, 2019Inventors: Catherine COULTER, Sean M. JOHNSTON, Farzaneh SEYEDI
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Publication number: 20190040003Abstract: The invention relates to a solvent-free green ammoximation process based on membrane distribution with a procedure as: adding TS-1 catalyst and ketone into a reactor in advance; setting the stirring speed and reaction temperature; after reaching the set temperature, adding a certain amount of ammonia and hydrogen peroxide into a reaction solution, wherein the hydrogen peroxide is fed in a way of using membrane as a distributor, the ammonia is fed in a continuous or semi-continuous manner; oxime is produced upon the reaction. The advantages of the invention include the mild reaction conditions, high reacting efficiency, simple operation and environmentally-friendly process. And there is no need to add any solvent during the reaction process. During the ammoximation reaction, both the conversion rate of the ketone and the selectivity of the oxime can be over 98.0%.Type: ApplicationFiled: July 31, 2015Publication date: February 7, 2019Applicant: Nanjing University of TechnologyInventors: Weihong XING, Honglin MAO, Rizhi CHEN, Hongnian SHANG, Nanping XU
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Publication number: 20190040004Abstract: Disclosed are new compounds for treating, preventing or inhibiting a parasitic disease, preferably toxoplasmosis in a subject, the method for preparing thereof.Type: ApplicationFiled: October 9, 2018Publication date: February 7, 2019Inventors: Denis SERENO, Gilles LABESSE, Jean-Francois Alexandre GUICHOU, Corinne LOEUILLET, Deborah Isabelle GARCIA, Stephane DELBECQ
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Publication number: 20190040005Abstract: The present invention relates to a process for preparing C4-C15 lactams, in which a C1-C10-alkyl nitrite is reacted with a C4-C15-cycloalkane and is illuminated with a light-emitting diode during the reaction. This forms a C4-C15-cyclohexanone oxime which is then converted further to a C4-C15 lactam; the C1-C10 alcohol formed is recycled into the preparation of the C1-C10-alkyl nitrite.Type: ApplicationFiled: January 30, 2017Publication date: February 7, 2019Inventors: Richard DEHN, Ahmad DEHESTANI, Klemens MASSONNE, Steffen WAGLÖHNER, Joaquim Henrique TELES, Thomas SCHAUB, Till Christian BRÜGGEMANN, Carlos TELLAECHE HERRANZ, Oliver TRAPP, Jedrzej WYSOCKI
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Publication number: 20190040006Abstract: Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.Type: ApplicationFiled: October 1, 2018Publication date: February 7, 2019Inventor: Lin Zhi
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Publication number: 20190040007Abstract: The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.Type: ApplicationFiled: February 10, 2017Publication date: February 7, 2019Applicant: PHARMAXIS LTD.Inventors: Alison Dorothy Findlay, Craig Ivan Turner, Mandar Deodhar, Jonathan Stuart Foot, Wolfgang Jarolimek, Wenbin Zhou, Alan Duncan Robertson
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Publication number: 20190040008Abstract: The present invention relates to novel compounds which are capable of inhibiting the interaction of LFA-1 with its counter ligands.Type: ApplicationFiled: August 2, 2018Publication date: February 7, 2019Applicant: ALLOCYTE PHARMACEUTICALS AGInventors: Werner BREITENSTEIN, Marianne HUERZELER, Terence KELLY, Riccardo MANCUSO, Gisbert SCHNEIDER, Gabriele WEITZ-SCHMIDT