Patents Issued in February 14, 2019
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Publication number: 20190046396Abstract: A coded collapsible drug reservoir and a drug delivery system including the coded collapsible drug reservoir. The drug reservoir includes a collapsible housing and a port in communication with the collapsible housing. The drug reservoir further includes a coding feature disposed on the drug reservoir, and the coding feature identifies the drug reservoir.Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventor: Richard James Vincent Avery
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Publication number: 20190046397Abstract: The present disclosure relates to improved collapsible blood containers comprising reinforced silicone for use in Oxygen Reduction Disposable kits (ORDKit), devices and methods. The improved collapsible blood containers and methods for the collection of blood and blood components provide for improved burst, tear, and puncture resistance.Type: ApplicationFiled: September 9, 2016Publication date: February 14, 2019Applicant: New Health Sciences, Inc.Inventors: Robert HARHEN, Peter PIGNONE, Narendran RENGANATHAN, Jancarlo SARITA, Jeffrey Karl SUTTON, Michael WOLF, Michael R. ZOCCHI
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Publication number: 20190046398Abstract: The present invention relates to a method for enabling hospitals or clinics to administer a dose of a drug to patients in need thereof while avoiding steps of manipulation, dilution, reconstitution, dispensing, sterilization, transfer, handling or compounding before intravenous administration. The present invention further relates to a perfusion system comprising different sets of perfusion containers, each container comprising a ready-to-infuse, stable, sterile, aqueous perfusion solution of a drug, wherein the set of perfusion containers alone or in combination provides for direct intravenous administration of a desired dose of the drug to a patient in need thereof, such that the delivered dose is equal to or within ±5% of the calculated dose.Type: ApplicationFiled: October 12, 2018Publication date: February 14, 2019Applicant: SUN PHARMACEUTICAL INDUSTRIES LIMITEDInventors: Samarth KUMAR, Prashant KANE, Subhas Balaram BHOWMICK, Kirti GANORKAR, Nishit PATEL, Ashish Anilrao DUBEWAR, Umeshkumar Mukeshbhai PATEL
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Publication number: 20190046399Abstract: Systems, devices and method to establish fluid communication between vessels. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Mikael NAYGAUZ
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Publication number: 20190046400Abstract: Systems, devices and method to establish fluid communication between vessels. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Mikael NAYGAUZ
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Publication number: 20190046401Abstract: A bag assembly includes a first panel secured to a second panel by a seam so that a cavity is formed between the first panel and the second panel, the seam encircling the cavity. A first seal couples together the first panel and the second panel at a location spaced apart from the seam so that the cavity encircles the first seal. In one embodiment, the first seal can be circular. A first port communicates with the cavity.Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventor: Rudolf Pavlik
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Publication number: 20190046402Abstract: A reconstitution device includes: a piercing member having a first end and a second end, the first end of the piercing member configured to engage an administration port; a delivery member having a first end and a second end, the first end of the delivery member configured to engage a delivery site; a collar configured to engage a vial; and a cap extending from the collar and holding the piercing member and the delivery member such that the second end of the piercing member and the second end of the delivery member are disposed within the cylindrical collar.Type: ApplicationFiled: August 10, 2017Publication date: February 14, 2019Inventors: Freddy Desbrosses, Pierpaolo Padula, Virgil Claudiu Manta, Valentin Champain
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Publication number: 20190046403Abstract: Systems, devices and method to establish fluid communication between vessels. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Mikael NAYGAUZ
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Publication number: 20190046404Abstract: Systems, devices and method to establish fluid communication between vessels. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Mikael NAYGAUZ
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Publication number: 20190046405Abstract: A fill adapter for filling a reservoir and a related method are disclosed herein. The fill adapter includes a button assembly actuator and a pump chamber plunger actuator hingably attached to the button assembly actuator, wherein the actuation of the button assembly actuator actuates the pump chamber plunger actuator and wherein the pump chamber plunger actuator actuates a pump chamber membrane before the at least one button assembly is actuated.Type: ApplicationFiled: October 18, 2018Publication date: February 14, 2019Inventors: Gregory R. Lanier, JR., Richard J. Lanigan, Stephen L. Fichera, Dean Kamen, Larry B. Gray
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Publication number: 20190046406Abstract: A top for a plasma storage container includes a top body that defines the structure of the top and seals an opening of the plasma storage container. The top also includes a first opening and a vent opening extending through the top body. A valve mechanism is located at least partially within the top body and includes an aperture therethrough. The aperture opens upon connection of a blunt cannula to provide access to the interior of the plasma storage container. The top also includes a vent filter. The vent filter allows air to vent through the vent opening during plasma collection.Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventors: Christopher S. McDowell, Matthew J. Murphy
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Publication number: 20190046407Abstract: A molded spike port including a first portion defining a first chamber, a plug disposed in the first chamber and configured to form a seal with the first portion, a second portion defining a second chamber, the second portion including a sealing ring configured to seal the spike port to a spike, a tip configured to be inserted into a fluid bag, the tip comprising a membrane, and a wall between the first portion and the second portion, wherein the wall is configured to break when the first portion is twisted relative to the second portion.Type: ApplicationFiled: August 9, 2017Publication date: February 14, 2019Inventors: Kahina Rabia, Makenzie Jones, Christopher Yim Chau, Eduardo Ignacio Muñoz Laverde
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Publication number: 20190046408Abstract: Systems, devices and method to establish fluid communication between vessels. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Mikael NAYGAUZ
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Publication number: 20190046409Abstract: Systems, devices and method to establish fluid communication between vessels. A vessel having at least two entry ports and at least one exit port, and at least one container containing a dosing regimen, the at least one container configured to be received by one of the at least two entry ports of the vessel, whereby upon connection of the at least one container to the one of the at least two entry ports of the vessel, the dosing regimen in the at least one container is transferred into the vessel. Modular dosing system for adding at least one amount of a medicament to a preparation in a modular construction. System for displaying a dosing regimen or single amount of a medicament, so that the administrator of the amount is able to precisely ascertain the amount administered to a patient.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Mikael NAYGAUZ
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Publication number: 20190046410Abstract: A syringe adaptor includes a body, shaped to define a body lumen, a syringe fitting at a proximal end of the body, configured to connect to a distal end of a syringe, a needle extending distally from the syringe fitting into the body lumen, a septum housing, and an elastomeric septum mounted inside the septum housing. The septum includes a proximal face, shaped to define an aperture having an aperture diameter, and a distal face. The septum is shaped to define a cavity, joined to the aperture, having a cavity diameter that is larger than the aperture diameter. The septum housing is configured to slide proximally within the body lumen such that a distal end of the needle contained in the cavity passes through the distal face of the septum. Other embodiments are also described.Type: ApplicationFiled: August 8, 2018Publication date: February 14, 2019Inventor: Eli Shemesh
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Publication number: 20190046411Abstract: The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The invention more particularly relates to self-supporting dosage forms which provide an active agent while providing sufficient buccal adhesion of the dosage form. Further, the present invention provides a dosage form which is useful in reducing the likelihood of diversion abuse of the active agent.Type: ApplicationFiled: October 17, 2018Publication date: February 14, 2019Inventors: Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz, Eric Dadey
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Publication number: 20190046412Abstract: A tablet and capsule dispensing assembly, comprising a case including an inner circumferential surface having a first plurality of teeth a tablet disc having a plurality of tablets disposed circumferentially thereon, the tablet disc arranged to rotate within the case, and a lock arranged to engage with the first plurality of teeth to prevent rotation of the tablet disc in a first rotational direction during a first predetermined time interval.Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventors: Robert Owen Brady, Joseph B. Bujalski, Jeffery S. Heitzenrater, Matthew William Vergin, Jon Colin Leonard, Joel Raymond Chartier
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Publication number: 20190046413Abstract: A feeding teat for use with a bottle that contains a fluid includes a nipple defining an orifice at a terminal end and an interior profile shaped by multiple intersecting reverse curves that generally decreases an interior diameter of the nipple toward the orifice for directing a flow of the fluid into the orifice, a flange configured to be releasably coupled to the bottle such that the fluid can flow from the bottle into the feeding teat, an intermediate portion integrally connecting the nipple to the flange, and a pressure relief valve extending laterally from the intermediate portion and configured to admit air into an interior region formed by the feeding teat and the bottle.Type: ApplicationFiled: August 3, 2018Publication date: February 14, 2019Inventors: Joshua Wiesman, Keith Tritschler, David Tesini
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Publication number: 20190046414Abstract: Disclosed are artificial nipples and methods of producing artificial nipples. Disclosed are methods of producing an artificial nipple comprising imaging a nipple region of a breast, wherein at least a portion of the breast comprising the nipple region is distorted due to at least a partial vacuum created through motions of lips and a tongue, wherein the imaging provides imaging data of the nipple region; and generating, based on the imaging data, an artificial nipple.Type: ApplicationFiled: August 13, 2018Publication date: February 14, 2019Inventor: Brittany Gledhill
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Publication number: 20190046415Abstract: Embodiments described herein include a baby bottle with integrated pacifier apparatus and method of use including a substantially elongated baby bottle and nipple mounted assembly which includes a pressure valve mechanism configured to regulate the flow of liquid through the nipple and prevent excess air from being ingested.Type: ApplicationFiled: August 8, 2017Publication date: February 14, 2019Inventor: Dustyn Zicafoose
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Publication number: 20190046416Abstract: The invention relates to a self-expandable tube having a catheter body with a double lumen in which one lumen allows for suctioning or decompression and another lumen for a feeding tube. A self-expandable portion collects secretions above the expandable portion or in the anatomical lumen and a suction source coupled to the self-expandable tube removes the secretions as is disclosed herein.Type: ApplicationFiled: April 9, 2018Publication date: February 14, 2019Inventor: Luis F. Angel
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Publication number: 20190046417Abstract: A FORS feeding tube system employing a feeding tube (30) for channeling a fluid flow from a proximal end and a distal end of the feeding tube (30), and further employing a FORS sensor (40) for generating sensing data informative of a shape reconstruction of a segment or an entirety of FORS sensor (40). The feeding tube (30) and the FORS sensor (40) are integrated to configure a FORS feeding tube (20), and the sensing data is further informative of a shape of a segment or an entirety of FORS feeding tube (20) derived from the integration of feeding tube (30) and FORS sensor (40). The FORS feed tube system may further employ a navigation controller to control a tracking of a positioning of a segment or an entirety of the FORS feeding tube (20) within an anatomical tract (e.g., a gastrointenstinal tract).Type: ApplicationFiled: February 10, 2017Publication date: February 14, 2019Inventors: MOLLY LARA FLEXMAN, NERIMAN NICOLETTA KAHYA, MARTINUS BERNARDUS VAN DER MARK
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Publication number: 20190046418Abstract: The present invention relates to dental cement composition that is more biocompatible and stimulates quicker healing of the damaged dental tissues. Specifically, the invention relates to dental cement composition comprising a combination of dental repair compounds consisting of nanoparticles of Tri-calcium Silicate (Ca3SiO5), Di-calcium Silicate (Ca2SiO4), Calcium Titanate (CaTiO3) and Hydroxyapatite (Ca10(PO4)6(OH)2).Type: ApplicationFiled: August 9, 2017Publication date: February 14, 2019Applicants: INM TECHNOLOGIES PVT LTD, SHILPA MEDICARE LTDInventors: GUNNESWARA SUBRAMANYA VARA PRASAD RANGABHATLA, SHRISHA BELALDAVARA, RATNA PHANI AYALASOMAYAJULA
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Publication number: 20190046419Abstract: The invention relates to a kit of parts for preparing a glass ionomer composition for dental use, the kit comprising a Paste A and a Paste B, Paste A comprising water, acid-reactive inorganic filler A, phyllo silicate(s), Paste B comprising water, poly-acid, non acid-reactive filler B, optionally chelating agent. The invention also relates to a hardenable composition obtainable by combining the pastes of the kit or parts and to the use of such a composition as or for preparing a dental cement, dental filling mater ial, dental core build up material or dental root channel filling material.Type: ApplicationFiled: February 16, 2017Publication date: February 14, 2019Inventors: Kai U. Claussen, Johannes M. Leykauff, Christine Lienau, Reinhold Hecht, Peter Braun, Markus Mikulla
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Publication number: 20190046420Abstract: A dental cement includes: a first component containing a glass powder; a second component containing a polycarboxylic acid-based polymer, an organic polybasic acid, and water. The glass powder contains zinc and silicon. A solubility of a salt of a conjugate base of the organic polybasic acid and zinc ions in water at 20° C. is greater than or equal to 1 g/100 mL.Type: ApplicationFiled: August 3, 2018Publication date: February 14, 2019Inventors: Toshihiko TACHIBANA, Tomoki KONO, Ryosuke YOSHIMITSU, Akishi ARITA, Mizuki NAKAYAMA
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Publication number: 20190046421Abstract: A sprayable sunscreen cosmetic contains substantially no ultraviolet ray scattering agents which cause whiteness, and which is transparent immediately after being applied/sprayed, and that has excellent ultraviolet ray protection effect and a good sensation in use. The ultraviolet ray protection effect is not reduced, and the effects improve when in contact with water. A water-in-oil emulsified sunscreen cosmetic comprises: (A) 6 to 40 mass % of an ultraviolet ray absorbing agent; (B) an organically modified clay mineral; (C) an oil phase thickener other than the aforementioned (B); (D) a silicone-based surfactant having an HLB of less than 8; (E) a spherical resin powder; and (F) a volatile silicone oil; wherein a ratio defined as [total amount of ingredient (B) and ingredient (C)]/[total amount of (G) non-volatile liquid oils other than silicone oils] is at least 0.04 and less than 0.68.Type: ApplicationFiled: October 7, 2016Publication date: February 14, 2019Applicant: SHISEIDO COMPANY, LTD.Inventors: Satoshi YAMAKI, Taichi HARADA, Takashi MATSUDA
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Publication number: 20190046422Abstract: The aspects presented herein provide methods and compositions for the reduction of the peroxide value of perfume ingredients, formulated perfumes, formulated body care products, formulated skin care products, formulated homecare products, essential oils, food raw materials, formulated food products, and natural extracts.Type: ApplicationFiled: October 17, 2018Publication date: February 14, 2019Inventors: Michael J. CALANDRA, Ying WANG
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Publication number: 20190046423Abstract: The present invention is directed to the hair care treatment compositions, including pre- and post-treatment compositions, containing select aryl alkanone compounds as quenching and/or chelating agents.Type: ApplicationFiled: August 9, 2018Publication date: February 14, 2019Applicant: SYTHEON LIMITEDInventor: Ratan K Chaudhuri
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Publication number: 20190046424Abstract: A personal care deodorant and/or antiperspirant product substantially void of any endocrine disrupting chemicals, and a method of making the same. Embodiments of the deodorant include one or more of the following: a skin conditioning agent, an emollient, a nonaqueous viscosity increasing agent, a surfactant/emulsifying agent, an absorbent, a soothing agent, a deodorant agent, a viscosity-controlling agent, and a scent.Type: ApplicationFiled: August 7, 2018Publication date: February 14, 2019Applicant: thinkOperations, LLCInventor: Kevin Brodwick
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Publication number: 20190046425Abstract: An oral care composition comprising (i) basic amino acid in free or salt form, (ii) calcium carbonate, (iii) a fluoride ion source, (iv) a flavoring agent comprising less than 50% menthol, and (v) an anionic surfactant, wherein the anionic surfactant is present in an amount from 1.00 weight % to 1.39 weight % is provided.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Applicant: Colgate-Palmolive CompanyInventors: Agnieszka KOCINSKA, Pierre LAMBERT, Sandra PEREIRA RAMOS, Nadia BUEB, Joshua SCHMID
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Publication number: 20190046426Abstract: A pro-fragrance composition includes a cucurbituril in complex with a fragrance molecule and use of the compositions in counteracting malodour. The cucurbituril is present as a mixture, wherein the mixture includes at least two different cucurbiturils selected from CB[5], CB[6], CB[7] and CB[8]. The complexed fragrance molecule is released when the composition is exposed to a stimulus. Also provides methods for the preparation of pro-fragrance complexes of cucurbiturils and fragrance molecules.Type: ApplicationFiled: February 15, 2017Publication date: February 14, 2019Applicant: AQDOT LIMITEDInventors: Roger COULSTON, Alexander TANNER, Jose MARTINEZ-SANTIAGO
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Publication number: 20190046427Abstract: The present invention provides a peptide which shows a hair growth-promoting activity. The peptide of the present invention promotes the growth of follicular cells and increases the expression of a hair growth-related growth factor and hair growth-related factors, thereby showing an excellent effect in hair growth. The peptide of the present invention can be used for preventing and alleviating hair loss, promoting hair growth, and improving hair growth. In addition, the superior activity and stability of the peptide of the present invention allows the peptide to be very favorably applied to quasi drugs and cosmetics.Type: ApplicationFiled: February 9, 2017Publication date: February 14, 2019Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung-Ji LEE, Min Woong KIM
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Publication number: 20190046428Abstract: A subject-matter of the present invention is a cosmetic composition comprising: *at least 4% by weight, with respect to the weight of the composition, of at least one polysaccharide alkyl ether comprising at least two different monosaccharide units, each unit comprising at least one hydroxyl group substituted by a C1-C24, preferably C1-C10, alkyl chain, at least one non-volatile polar hydrocarbon first oil, at least one second oil, incompatible with the first oil or oils, chosen from non-volatile silicone oils, from non-volatile fluorinated oils, or their combinations, *optionally at least one non-volatile third oil, different from the first oil or oils and different from the second oil or oils, chosen from polar or non-polar hydrocarbon oils, phenylated silicone oils not comprising a dimethicone fragment, or their mixtures, the content of polysaccharide alkyl ether and of second oil(s) representing at least 35% by weight, with respect to the weight of the composition.Type: ApplicationFiled: February 27, 2017Publication date: February 14, 2019Applicant: L'OREALInventors: Florence LAHOUSSE, Emilie HENIN
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Publication number: 20190046429Abstract: A biocompatible, degradable dermal filler system is composed of unmodified macroporous chitosan microbeads dispersed uniformly in a continuous phase composed of cross-linked hyaluronic acid gel particles and unmodified hyaluronic acid.Type: ApplicationFiled: February 9, 2017Publication date: February 14, 2019Applicant: Prollenium Medical Technologies, Inc.Inventors: Ario Khoshbin, Khasha Ighanian, Shadi Moghadam, Yan Li, Hitoshi Masui, Stephen J. Kennedy, Timothy Lee
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Publication number: 20190046430Abstract: I disclose a silicone-based liquid cosmetic primer that has utility for protecting skin and makeup. The product is dispensed from a liquid dropper and applied to facial skin before the application of foundation or makeup. It has an extremely high silicone content, 65-99% by weight and preferably 85-95%. The silicone forms a protective layer between the skin and makeup. The silicone barrier formed by this product protects the skin from absorption of irritants and toxins in the cosmetics. Simultaneously, the cosmetic products are protected from oil and sweat for longer-lasting duration. The product also contains small concentrations of Vitamin E, lychee oil, and gold dust.Type: ApplicationFiled: October 14, 2018Publication date: February 14, 2019Inventor: Ashley Holbrook
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Publication number: 20190046431Abstract: Disclosed is a fiber elasticity conserving hair relaxer composition having an alkalinity of at least pH 12 comprising a fiber elasticity conserving amount of at least one hair fiber elasticity conserving agent selected from the group consisting of poly-organosiloxanes containing, per molecule, at least one siloxyl unit substituted with at least one group having one or more of a sterically hindered piperidinyl functional group. The composition substantially ameliorates the loss of hair fiber elasticity that frequently occurs during the hair relaxing step of a process for relaxing the natural curl of hair under such strongly alkaline conditions.Type: ApplicationFiled: May 5, 2017Publication date: February 14, 2019Applicant: AVLON INDUSTRIES, INC.Inventor: Ali N. SYED
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Publication number: 20190046432Abstract: The present invention provides a crude extract from the bark of an Acer rubrum (AR) tree and/or Picea mariana (PM), method of preparation and its use for inhibiting the signs of skin aging (such as wrinkles and/or dehydration) caused by at least one of: increased elastase activity, increased collagenase activity, decreased elastin synthesis, decreased collagen synthesis or decreased involucrin synthesis, in skin fibroblast cells, particularly those of a human subject.Type: ApplicationFiled: August 11, 2017Publication date: February 14, 2019Inventor: Mariana ROYER
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Publication number: 20190046433Abstract: Aerosol formulations comprising glycopyrronium bromide in combination with formoterol are useful for the prevention or treatment of chronic obstructive pulmonary disease. The formulation further comprises a HFA propellant, a co-solvent, and an amount of inorganic acid sufficient to stabilize both the glycopyrronium bromide and the formoterol components. Optionally the formulation may further comprise beclometasone dipropionate.Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Applicant: CHIESI FARMACEUTICI S.P.A.Inventors: Sauro BONELLI, Francesca USBERTI, Enrico ZAMBELLI
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Publication number: 20190046434Abstract: Non-invasive Ocular Drug Delivery Insert Technology. The invention concerns an ocular insert which is a new biocompatible polymer-based controlled drug delivery system (CDDS) applicable to a variety of drugs and other compounds for the treatment of different ocular pathologies. This ocular insert allows releasing of at least one drug under suitable concentration levels during suitable periods of time. The device may be inserted in the lower or upper fornix conjunctiva, in a non-invasive way, meaning that the patient will be able to place the device himself, without intervention of medical specialized staff. The insert of the invention will release the drug in such a controlled rate that will allow the drug release up to 300 days by either a “Fickian” or a linear profile according to the intend purpose or pathology.Type: ApplicationFiled: February 10, 2017Publication date: February 14, 2019Inventors: Marcos João MOTA LEITE MACHADO MARIZ, Paula Cristina NUNES FERREIRA CALVINHO, Maria Helena MENDES GIL, Joaquim Carlos NETO MURTA
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Publication number: 20190046435Abstract: The present invention recognizes that medical devices, such as but not limited to contact lenses, can be made having a coating made at least in part using printing technologies to provide drug storage and drug release structures. The coating preferably includes at least one drug reservoir layer and a least one barrier layer, and can include structures, such as but not limited to capillary structures, which alone or in combination modulate the release of the drug from the coating. One aspect of the present invention is a medical device that incorporates a drug in at least one coating. A second aspect of the present invention is a method of making a medical device that incorporates a drug in at least one coating. A third aspect of the present invention is a method of using a medical device of the present invention to treat or prevent a disease, disorder or condition.Type: ApplicationFiled: October 12, 2018Publication date: February 14, 2019Inventor: Praful Doshi
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Publication number: 20190046436Abstract: The present disclosure generally relates to nicotine formulations, nebulizer systems comprising same and uses thereof via inhalation.Type: ApplicationFiled: February 28, 2017Publication date: February 14, 2019Inventor: Miron HAZANI
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Publication number: 20190046437Abstract: The present disclosure relates to pharmaceutically acceptable complex formulae comprising complexes of Abiraterone acetate and pharmaceutically acceptable excipients, process for the preparation thereof and pharmaceutical compositions containing them. The complex formulae of the present disclosure have improved physicochemical properties which results in reduced food effect which allows significant dose reduction and the abandoning of the requirement of taking the drug on an empty stomach.Type: ApplicationFiled: October 17, 2018Publication date: February 14, 2019Inventors: Réka ANGI, Tamás JORDÁN, Orsolya BASA-DÉNES, Tamás SOLYMOSI, Zsolt ÖTVÖS, Hristos GLAVINAS, Genovéva FILIPCSEI
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Publication number: 20190046438Abstract: In accordance with the present disclosure, there are provided formulations comprising: (a) at least one active agent; (b) an oil, and optionally a thickener therefor; (c) an organic solvent, and a thickener therefor; and (d) an oil and/or solvent soluble skin penetration enhancer; wherein: said formulation comprises <10 wt % water; and said formulation optionally forms a thixotropic thinning gel. Also provided are gels comprising oil and organic solvent, methods for preparing same and methods for the topical delivery of an active agent to a subject in need thereof.Type: ApplicationFiled: March 31, 2017Publication date: February 14, 2019Inventor: Thomas HNAT
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Publication number: 20190046439Abstract: A stabilized composition for the controlled delivery of probiotics includes an aqueous solution of crystalloids and colloids comprised of water insoluble polymers with the ability to de-swell upon electrical charge. The composition further includes a plurality of oil droplets and a base solution. The composition further include a destabilizing solution comprising a solvent, nitrogen, a natural acid sufficient to produce a pH of about 3.0 to about 4.5, and a sufficient amount of a salt to contribute to an osmolality between about 190 mOsm/L and about 900 mOsm/L. The composition further includes a plurality of microencapsulated probiotic beads, wherein the plurality of microencapsulated probiotic beads comprises between about 0.01% to about 20% of the composition by weight.Type: ApplicationFiled: October 15, 2018Publication date: February 14, 2019Inventors: MaryAnne Maya IVANJESKU, Kristin DAUGHERTY, Tatjana BOHINC, Stephen BUCKLEY
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Publication number: 20190046440Abstract: The present disclosure provides methods and systems for forming stable droplets as part of an emulsion. The emulsion may be, for example, formed by bringing an aqueous phase in contact with an oil phase at a droplet generation junction of a droplet generator. Droplets of the present disclosure may be used for holding compositions for various uses.Type: ApplicationFiled: August 17, 2018Publication date: February 14, 2019Applicant: Ojai Energetics PBCInventors: William Kleidon, Justin Kirkland
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Publication number: 20190046441Abstract: A self-foaming composition including ivermectin is described for a no-rinse topical application and for application to the skin. The composition can include at least one intermediate composition B including a gas-generating agent; at least one intermediate composition A including an agent for activating the gas-generating agent; and ivermectin being present in at least one of the intermediate compositions A and B. Also described, is a kit or a single container including a plurality of compartments including such a composition.Type: ApplicationFiled: September 27, 2016Publication date: February 14, 2019Inventors: Jean-Christophe BUGE, Karine NADAU-FOURCADE
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Publication number: 20190046442Abstract: The present invention relates to a CD-RAP precursor protein comprising a pre-sequence and CD-RAP, and its use in manufacturing of native CD-RAP. The present invention further relates to a composition comprising CD-RAP and at least one positively charged amino acid and a buffer, pharmaceuticals comprising said composition, their use in methods of treating and/or preventing cartilage disease or injury in patients suffering from aggrecan degradation, and/or increased influx of water into the cartilage, and/or decreased CD-RAP expression, as well as methods of producing said composition and methods of storing CD-RAP in said composition. The present invention further relates to a composition comprising liposomes comprising encapsulated CD-RAP or a variant thereof, its use in methods of treating joint disease or injury, and methods of producing such liposomal composition as well as storing CD-RAP therein.Type: ApplicationFiled: September 16, 2016Publication date: February 14, 2019Inventors: Isabell SCHOETTLE, Judith STOMMES, Paul HABERMANN, Bernd JANOCHA, Ursula STILLGER, Eckart BARTNIK, Volker JESKE, Joachim SAAS
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Publication number: 20190046443Abstract: Embodiments of the invention relate to liposomes comprising: a lipid bilayer having an internal cavity; a therapeutic agent within the internal cavity configured to modify expression or degradation of WASp in a cell; and a targeting moiety external to the lipid bilayer configured to target an extracellular domain of a cell. Embodiments of the invention relate to methods of treatment of disease comprising administering the liposomes. Novel pharmaceutical compositions are also disclosed.Type: ApplicationFiled: October 29, 2018Publication date: February 14, 2019Inventor: Mira BARDA-SAAD
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Publication number: 20190046444Abstract: Disclosed herein are pharmaceutical compositions and methods for oral, sublingual or subcutaneous administration comprising a sterically stabilized liposome carrier comprising: i) poly (ethylene glycol) distearoylphosphatidylethanolamine (PEG-DSPE); and ii) at least one of phosphatidylglycerol and phosphatidylcholine. Compositions and methods for treatment of food allergy and eosinophilic esophagitis are also described.Type: ApplicationFiled: September 14, 2016Publication date: February 14, 2019Inventors: Kameswari KONDURI, Nejat DUZGUNES, Jogi PATTISAPU, Ram PATTISAPU
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Publication number: 20190046445Abstract: The present invention relates to polymersomes that contain an encapsulated drug and that exhibit chemotaxis in response to a chemical stimulus. The chemotactic polymersomes can be targeted in vivo to a location of therapeutic interest with high specificity and selectivity. The present invention also provides related pharmaceutical compositions and therapeutic methods.Type: ApplicationFiled: January 27, 2017Publication date: February 14, 2019Inventor: Giuseppe BATTAGLIA