Patents Issued in February 26, 2019
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Patent number: 10214441Abstract: Provided is a cutting device including a machining table configured to float a workpiece having a plate shape, a laser radiation unit configured to radiate a laser beam onto the workpiece, a coolant injection unit configured to inject a coolant onto the workpiece, and a moving device configured to relatively move the workpiece with respect to the laser radiation unit and the coolant injection unit in a preset direction. In the cutting device, a scattering member configured to receive injection of the coolant from the coolant injection unit and scatter the coolant is installed at the machining table in front of the workpiece in a moving direction in which the workpiece relatively moves.Type: GrantFiled: April 9, 2015Date of Patent: February 26, 2019Assignee: IHI CORPORATIONInventor: Junichi Yamada
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Patent number: 10214442Abstract: Vitreous or at least partly crystallized sealing material is provided. The sealing material is from the system SiO2—B2O3—CaO—MgO, which is free from BaO and/or SrO and which has an improved coefficient of thermal expansion and improved crystallization properties. The sealing material is employed to produce joint connections, electrical feedthroughs, and/or as a barrier layer.Type: GrantFiled: April 22, 2016Date of Patent: February 26, 2019Assignee: SCHOTT AGInventor: Jens Suffner
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Patent number: 10214443Abstract: Lithium silicate materials are described which can be easily processed by machining to dental products without undue wear of the tools and which subsequently can be converted into lithium silicate products showing high strength.Type: GrantFiled: September 2, 2016Date of Patent: February 26, 2019Assignee: Ivoclar Vivadent AGInventors: Elke Signer-Apel, Wolfram Höland, Marcel Schweiger, Christian Ritzberger, Harald Bürke, Volker Rheinberger
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Patent number: 10214444Abstract: The present invention relates to a method for treating a surface of an object which comprises the steps consisting of bringing the surface to be treated in contact with a diffusion intermediate and then maintaining said surface to be treated in contact with said diffusion intermediate without any movement relatively to each other, said diffusion intermediate being impregnated with a corrosive solution prior to contacting or during said contacting. The present invention also relates to a device implemented during such a method.Type: GrantFiled: June 6, 2014Date of Patent: February 26, 2019Assignee: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVESInventors: Fabien Pilon, Philippe Belleville, Sébastien Lambert, Olivier Rondeau, Sandrine Thomas
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Patent number: 10214445Abstract: Embodiments of an article including a substrate and a patterned coating are provided. In one or more embodiments, when a strain is applied to the article, the article exhibits a failure strain of 0.5% or greater. Patterned coating may include a particulate coating or may include a discontinuous coating. The patterned coating of some embodiments may cover about 20% to about 75% of the surface area of the substrate. Methods for forming such articles are also provided.Type: GrantFiled: March 17, 2015Date of Patent: February 26, 2019Assignee: CORNING INCORPORATEDInventors: Shandon Dee Hart, Guangli Hu, Nicholas James Smith
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Patent number: 10214446Abstract: A coated article includes a temperable antireflection (AR) coating that utilizes medium and low index (index of refraction “n”) layers having compressive residual stress in the AR coating. In certain example embodiments, the coating may include the following layers from the glass substrate outwardly: silicon oxynitride (SiOxNy) medium index layer/high index layer/low index layer. In certain example embodiments, depending on the chemical and optical properties of the high index layer and the substrate, the medium and low index layers of the AR coating are selected to cause a net compressive residual stress and thus optimize the overall performance of the antireflection coating when the coated article is tempered and/or heat-treated.Type: GrantFiled: October 24, 2017Date of Patent: February 26, 2019Assignee: Guardian Glass, LLCInventors: David M. Broadway, Yiwei Lu
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Patent number: 10214447Abstract: Certain example embodiments relate to a coated article including at least one infrared (IR) reflecting layer of a material such as silver or the like in a low-E coating, and methods of making the same. In certain cases, at least one layer of the coating is of or includes nickel and/or titanium (e.g., NixTiyOz). The provision of a layer including nickel titanium and/or an oxide thereof may permit a layer to be used that has good adhesion to the IR reflecting layer, and reduced absorption of visible light (resulting in a coated article with a higher visible transmission). When a layer including nickel titanium oxide is provided directly over and/or under the IR reflecting layer (e.g., as a barrier layer), this may result in improved chemical and mechanical durability. Thus, visible transmission may be improved if desired, without compromising durability; or, durability may simply be increased.Type: GrantFiled: October 30, 2017Date of Patent: February 26, 2019Assignees: Guardian Glass, LLC, Guardian Europe S.A.R.L.Inventors: Marcus Frank, Anton Dietrich, Greg Miller, Richard Blacker, Muhammad Imran, Jean-Marc Lemmer
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Patent number: 10214448Abstract: A method includes transferring at least one feed stream including calcium oxide, calcium carbonate, water, and a fluidizing gas into a fluidized bed; contacting the calcium oxide with the water; based on contacting the calcium oxide with the water, initiating a hydrating reaction; producing, from the hydrating reaction, calcium hydroxide and heat; transferring a portion of the heat of the hydrating reaction to the calcium carbonate; and fluidizing the calcium oxide, calcium hydroxide, and the calcium carbonate into a first fluidization regime and a second fluidization regime. The first fluidization regime includes at least a portion of the calcium carbonate and at least a portion of the calcium oxide, and the second fluidization regime includes at least a portion of the calcium hydroxide and at least another portion of the calcium oxide. The first fluidization regime is different than the second fluidization regime.Type: GrantFiled: May 10, 2017Date of Patent: February 26, 2019Assignee: Carbon Engineering Ltd.Inventors: Kenton Robert Heidel, Robert A. Rossi
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Patent number: 10214449Abstract: Dark colored roofing granules include an inert base particle coated with a composition including a metal silicate, a non-clay latent heat reactant, and a dark colored but solar reflective pigment.Type: GrantFiled: November 30, 2015Date of Patent: February 26, 2019Assignee: CertainTeed CorporationInventors: Husnu M. Kalkanoglu, Thomas McShea, Ming Liang Shiao
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Patent number: 10214450Abstract: Hardener composition for an addition-polymerization-curable synthetic fixing mortar system for embedding anchoring means in mortar in holes or crevices, wherein the hardener composition includes oligomeric siloxanes having on average per molecule at least one or preferably two or more organic radicals that carry one or more (secondary or primary) amino and/or thiol groups that react with isocyanate or epoxy groups in the addition reaction and having on average per molecule at least one or more hydrolysable groups, and, in addition, can include one or more further customary additives, to synthetic fixing mortar systems including such a hardener composition, to the use of such synthetic fixing mortar systems for embedding anchoring means in mortar in holes or crevices and to methods of producing and using the synthetic fixing mortar systems and the hardener composition.Type: GrantFiled: September 9, 2015Date of Patent: February 26, 2019Assignee: FISCHERWERKE GMBH & CO. KGInventors: Jürgen Grün, Martin Vogel, Christian Schlenk, Christian Weinelt
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Patent number: 10214451Abstract: Skins and/or adhesive layers are formed on a porous ceramic honeycomb by applying a layer of a cement composition to a surface of the honeycomb and firing the cement composition. The cement composition contains a water-swellable clay, high aspect inorganic filler particles and water, and are nearly or completely devoid of particles smaller than 100 nm and a cellulosic polymer.Type: GrantFiled: December 10, 2012Date of Patent: February 26, 2019Assignee: DOW GLOBAL TECHNOLOGIES LLCInventors: Aleksander J. Pyzik, Sharon Allen, Peter C. Saucier
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Patent number: 10214452Abstract: A geopolymer foam formulation, comprising at least one inorganic binder selected from the group consisting of latently hydraulic binders, pozzolanic binders and mixtures thereof; at least one alkaline activator selected from the group consisting of alkali metal hydroxides, alkali metal carbonates, alkali metal aluminates, alkali metal silicates and mixtures thereof; at least one surfactant selected from the group consisting of anionic surfactants, cationic surfactants, non-ionic surfactants and mixtures thereof; a gas phase and water. This formulation can also comprise a cement, and also additives for foam stabilization, shrinkage reduction, flexibilization, hydrophobization, or dispersion, fibers and fillers or a mixture thereof, and can be a single-component or two-component formulation.Type: GrantFiled: October 14, 2014Date of Patent: February 26, 2019Assignee: Construction Research & Technology, GmbHInventors: Sarunas Turcinskas, Sven Mönnig, Maxim Pulkin, Gregor Herth, Shengzhong Zhou
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Patent number: 10214453Abstract: The present invention relates to advanced cement free composition for concrete and panels useful in construction industry and the method of preparation thereof. Particularly the present invention relates to advanced cement free composition constituting Sea sand, Fly Ash, Seawater, NaOH and Na2SiO3 (sodium meta silicate). More particularly the present invention relates to advanced cement free composition for concrete and panels with comprehensive strength of 15 to 30 MPa and flexural strength of 1.5-3.0 MPa.Type: GrantFiled: September 27, 2017Date of Patent: February 26, 2019Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Sudhir Sitaram Amritphale, Sarika Verma, Mohammed Akram Khan, Prabha Padmakaran, Avneesh Anshul, Satyabrata Das
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Patent number: 10214454Abstract: A method for manufacturing micropowder is provided, which includes (a) mixing a silicon precursor and a carbon precursor to form a mixture, and heating and keeping the mixture at 1600° C. to 1800° C. under a vacuum and non-oxygen condition for 120 to 180 minutes to form a silicon carbide powder; and (b) heating and keeping the silicon carbide powder at 1900° C. to 2100° C. under non-oxygen condition for 5 to 15 minutes, and then cooling and keeping the silicon carbide powder at 1800° C. to 2000° C. under the non-oxygen condition for 5 to 15 minutes to form micropowder, wherein the micropowder includes a silicon carbide core covered by a carbon film.Type: GrantFiled: July 20, 2018Date of Patent: February 26, 2019Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ta-Ching Hsiao, Wen-Po Tu, Chu-Pi Jeng, Mu-Hsi Sung
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Patent number: 10214455Abstract: Provided herein are methods of making composite materials. The methods may include infiltrating a carbon nanoscale fiber network with a ceramic precursor, curing the ceramic precursor, and/or pyrolyzing the ceramic precursor. The infiltrating, curing, and pyrolyzing steps may be repeated one or more times. Composite materials also are provided that include a ceramic material and carbon nanoscale fibers.Type: GrantFiled: April 20, 2017Date of Patent: February 26, 2019Assignee: Florida State University Research Foundation, Inc.Inventor: Chengying Xu
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Patent number: 10214456Abstract: A composition is generally provided that includes a silicon-containing material (e.g., silicon metal and/or a silicide) and a boron-doped refractory compound, such as about 0.001% to about 85% by volume of the boron-doped refractory compound (e.g., about 1% to about 60% by volume). In one embodiment, a bond coating on a surface of a ceramic component is generally provided with the bond coating including such a composition, with the silicon-containing material is silicon metal.Type: GrantFiled: September 16, 2016Date of Patent: February 26, 2019Assignee: General Electric CompanyInventors: Glen Harold Kirby, Julin Wan
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Patent number: 10214457Abstract: A composition is provided that includes a silicon-containing material (e.g., a silicon metal and/or a silicide) and about 0.001% to about 85% of a Ga-containing compound, an In-containing compound, or a mixture thereof. The silicon-based layer can be a bond coating directly on the surface of the substrate. Alternatively or additionally, the silicon-based layer can be an outer layer defining a surface of the substrate, with an environmental barrier coating on the surface of the substrate. A coated component is also provided, as well as a method for coating a ceramic component. Gas turbine engines are also provided that include such a ceramic component.Type: GrantFiled: September 16, 2016Date of Patent: February 26, 2019Assignee: General Electric CompanyInventors: Glen Harold Kirby, Julin Wan
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Patent number: 10214458Abstract: This invention relates to processes and systems for converting fresh food waste into nutrient rich hydrolysates and particulate compositions. The invention also relates to the hydrolysates and compositions useful, for example, as fertilizers, feedstock or other nutrient supplements.Type: GrantFiled: December 13, 2016Date of Patent: February 26, 2019Assignee: CALIFORNIA SAFE SOIL, LLCInventors: Daniel M. Morash, Mark LeJeune
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Patent number: 10214459Abstract: Methods are described for preventing corrosion in a corrosion-aggressive media. The methods include combining a stannous corrosion inhibitor composition with a corrosion-aggressive media (such as a nitrogen-based solution, or more specifically a liquid solution of AN or UAN) to provide a treated solution. The stannous corrosion inhibitor composition may include a caustic. Also described is a liquid including from 0.1 wt % to 25 wt % of a stannous salt and from 1 wt % to 50 wt % of a caustic, and a liquid composition including a solution of urea ammonium nitrate and a stannous material. The liquid and stannous corrosion inhibitor compositions substantially prevent corrosion of a metal surface even when used in very small amounts and at a low pH.Type: GrantFiled: July 12, 2016Date of Patent: February 26, 2019Assignee: CHEMTREAT, INC.Inventors: Rajendra Prasad Kalakodimi, Joseph Clatterbuck, Tzongyeu Du
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Patent number: 10214460Abstract: An improved ignition and/or booster composition contains a boron-containing constituent such as boron carbide or a metal boride, and, an oxidizer such as potassium perchlorate. A gas generator and a vehicle occupant protection system containing the composition are also included.Type: GrantFiled: June 5, 2015Date of Patent: February 26, 2019Assignee: Joyson Safety Systems Acquisition LLCInventor: Scott M. Rambow
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Patent number: 10214461Abstract: A process for producing olefins from oxygenates can include the following steps: (i) heterogeneously catalyzed conversion of at least one oxygenate to a product stream containing C2 olefins, C3 olefins, C4 olefins, C5/6 hydrocarbon compounds, and C7+ hydrocarbon compounds; and (ii) separation of a propylene stream consisting of C3 olefins for at least 95 wt-%, wherein at least 10 wt-% of the propylene stream are recirculated into process step (i).Type: GrantFiled: September 2, 2015Date of Patent: February 26, 2019Assignee: L'Air Liquide Societe Anonyme Pour L'Etude Et L'Exploitation Des Procedes Georges ClaudeInventors: Martin Rothamel, Stephane Haag, Frank Castillo-Welter, Peter Trabold, Martin Gorny, Sven Pohl
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Patent number: 10214462Abstract: A process for post synthesis treatment of ZSM-5 catalyst for converting ethylene to liquid fuel products providing substantially improved catalyst life. The treatment comprises either a base treatment, an acid treatment or a two-step treatment where one is with an acid and the other is with a base. The base treatment is provided by a weak sodium hydroxide such as less than 1 Molar concentration. The acid treatment is stronger acid where, for example, a hydrogen chloride solution at greater than 2 Molar concentration is used.Type: GrantFiled: July 21, 2016Date of Patent: February 26, 2019Assignee: Phillips 66 CompanyInventors: Jianhua Yao, Bruce B. Randolph
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Patent number: 10214463Abstract: The present invention relates to a production method of an ?-olefin oligomer for producing an ?-olefin by performing an oligomerization reaction of an ?-olefin in a reaction solvent in the presence of a catalyst in a reactor, which is a production method of an ?-olefin oligomer, comprising circulating and feeding, to the reactor, a condensate liquid obtained by introducing part of gas of the gas phase part inside the reactor into a heat exchanger and cooling the gas, wherein the condensate liquid circulated and fed to the reactor is dispersed in the gas phase part inside the reactor; and a production apparatus of an ?-olefin oligomer.Type: GrantFiled: March 21, 2017Date of Patent: February 26, 2019Assignee: MITSUBISHI CHEMICAL CORPORATIONInventor: Hiroki Emoto
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Patent number: 10214464Abstract: A reactor comprising a thermal barrier surrounding a combustion zone. The reactor further comprises a cooling jacket inner wall and a binder disposed between the cooling jacket inner wall and the thermal barrier, and a cooling jacket outer wall, wherein the cooling jacket inner wall and the cooling jacket outer wall define a cooling channel. The reactor further comprises an outer reactor wall disposed over the cooling jacket outer wall, wherein the outer reactor wall is impermeable and is configured to contain high pressure gas within the reactor.Type: GrantFiled: May 4, 2017Date of Patent: February 26, 2019Assignee: UOP LLCInventors: Antoine Negiz, Robert B. James, Carl J. Stevens, Donald L. Mittendorf
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Patent number: 10214465Abstract: The present subject matter describes processes for increasing overall aromatics and xylenes yield in an aromatics complex. More specifically, the process for increasing overall aromatics and xylenes yield in an aromatics complex accomplishes the increased yields by incorporating an A8-A10 isomerization step into the aromatics complex. This isomerization integration increases the para-xylene.Type: GrantFiled: May 31, 2018Date of Patent: February 26, 2019Assignee: UOP LLCInventors: Stanley J. Frey, Patrick C. Whitchurch, Keith A. Couch
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Patent number: 10214466Abstract: According to one embodiment described in this disclosure, a process for producing propylene may comprise at least partially metathesizing a first stream comprising at least about 10 wt. % butene to form a metathesis-reaction product, at least partially cracking the metathesis-reaction product to form a cracking-reaction product comprising propylene, and at least partially separating propylene from the cracking-reaction product to form a product stream comprising at least about 80 wt. % propylene.Type: GrantFiled: July 24, 2018Date of Patent: February 26, 2019Assignee: Saudi Arabian Oil CompanyInventors: Sohel Shaikh, Aqil Jamal, Zhonglin Zhang
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Patent number: 10214467Abstract: The present invention describes a process for the simulated moving bed separation of xylenes which can be used for the treatment of paraxylene-rich feeds (more than 25% by weight of paraxylene), in which the operating conditions are optimized by means of a specific relationship between the cycle time and the desorbant flow rate.Type: GrantFiled: May 17, 2018Date of Patent: February 26, 2019Assignee: IFP Energies nouvellesInventors: Alexandre Vonner, Damien Leinekugel Le Cocq, Catherine Laroche, Pascal Etienne
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Patent number: 10214468Abstract: This invention discloses a method for co-production of 1-chloro-3,3,3-trifluoropropene, 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene. This method includes inputting the mixed gases of hydrogen fluoride and 1,1,1,3,3-pentachloropropane together with 1,1,2,3-tetrachloropropene into a first reactor for a reaction to obtain a reaction product; directly inputting the reaction product into a second reactor to perform a reaction in the presence of a catalyst; separating hydrogen chloride from the obtained product; obtaining 1-chloro-3,3,3-trifluoropropene, 2,3,3,3-tetrafluoropropene and 1,3,3,3-tetrafluoropropene respectively after water washing, alkaline washing, drying and rectifying. This invention has the advantages of flexible production, simple process, small investment, low energy consumption and high conversion rate.Type: GrantFiled: March 8, 2017Date of Patent: February 26, 2019Assignees: Zhejiang Quzhou Juxin Fluorine Chemical Co., Ltd., Zhejiang Quhua Fluor-Chemistry Co Ltd, Zhejiang Engineering Design Co., Ltd.Inventors: Jiangyong Hong, Aiguo Wang, Bo Yang, Yan Zhang, Guojun Yu, Yang Zhao, Hao Ouyang, Hao Pan
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Patent number: 10214469Abstract: A method for producing high-efficiency methanol capable of reducing emission of carbon dioxide. The method includes: a first step of preparing mixed gas by using steam and natural gas as raw materials and converting C2+ hydrocarbon contained in the natural gas into methane on a catalyst; a second step of preparing a synthesis gas including carbon monoxide, carbon dioxide, and hydrogen by reforming the mixed gas in a reformer filled with a reforming catalyst; and a third step of preparing methanol by using the synthesis gas as the raw material and reacting the synthesis gas.Type: GrantFiled: July 2, 2015Date of Patent: February 26, 2019Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGYInventors: Ki Won Jun, In Hyuck Choi, Chun Dong Zhang
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Patent number: 10214470Abstract: A method and system for preparing a mixture of Guerbet alcohols where one or more primary alcohols of the formula RCH2CH2OH are provided, with R representing hydrogen or a straight or branched chain alkyl group of 1 to 14 carbon atoms. A base and a catalyst are provided, which are mixed with the primary alcohol(s). The resulting mixture is heated to a process temperature above the boiling point of water under reaction conditions and the water resulting from the thus obtained condensation and dehydration of the primary alcohols is then removed constantly. When the Guerbet reaction has reached a certain stage, at least part of the reaction mixture is removed, followed by a separation of the desired Guerbet alcohols from the removed part of the reaction mixture. The other alcohols are then returned to the reaction mixture for obtaining a higher amount of the desired Guerbet alcohols.Type: GrantFiled: February 20, 2015Date of Patent: February 26, 2019Assignees: Arkema France, Warter Fuels Spolka AkeyjnaInventors: Jean-Luc Dubois, Wei Zhao, Raf Edward Anna Roelant, Hans Keuken, Pedro Miguel Ramos Borges
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Patent number: 10214471Abstract: The process for preparing 1,2-propanediol from propene and hydrogen peroxide comprises the steps of a) reacting propene with hydrogen peroxide in the presence of a catalyst mixture comprising a phase transfer catalyst and a heteropolytungstate, wherein the reaction is carried out in a liquid mixture comprising an aqueous phase having a pH of at most 6 and an organic phase, b) separating the biphasic mixture from step a) into an aqueous phase and an organic phase comprising propene oxide, c) recycling the propene oxide present in the separated organic phase into the reaction of step a) and d) separating 1,2-propanediol from the aqueous phase separated in step b).Type: GrantFiled: November 1, 2016Date of Patent: February 26, 2019Assignee: Evonik Degussa GmbHInventors: Holger Wiederhold, David Bolz, Bernd Jaeger, Hans-Jürgen Köhle, Sebastian Imm, Georg Friedrich Thiele
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Patent number: 10214472Abstract: A solubilizer is used to stabilize crude polyol produced from biomass.Type: GrantFiled: December 6, 2012Date of Patent: February 26, 2019Assignee: SIKA TECHNOLOGY AGInventors: Dieter Honert, Hans Knauber, Thomas Müller
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Patent number: 10214474Abstract: Disclosed is the oxidation of uronic acids, such as galacturonic acid, to the corresponding aldaric acids, such as galactaric acid, under neutral or acidic conditions. Use is made of a supported gold catalyst. The oxidation occurs in good selectivity and yield, under unexpectedly mild conditions. A source of galacturonic acids is pectins, such as from sugar beet pulp.Type: GrantFiled: October 6, 2015Date of Patent: February 26, 2019Assignee: COOPERATIE KONINKLIJKE COSUN U.A.Inventors: Daniël Stephan van Es, Rajeesh Kumar Pazhavelikkakath Purushothaman, Augustinus Emmanuel Frissen, Jacobus van Haveren, Frits van der Klis
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Patent number: 10214475Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises: (a) purifying the feed mixture in a first chromatographic separation step using an eluent a mixture of water and a first organic solvent, to obtain an intermediate product; and (b) purifying the intermediate product in a second chromatographic separation step using as eluent a mixture of water and a second organic solvent, to obtain the PUFA product, wherein the second organic solvent is different from the first organic solvent and has a polarity index which differs from the polarity index of the first organic solvent by between 0.1 and 2.Type: GrantFiled: January 20, 2017Date of Patent: February 26, 2019Assignee: BASF Pharma (Callanish) LimitedInventors: Adam Kelliher, Angus Morrison
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Patent number: 10214476Abstract: The present invention relates to the use of compounds for the treatment or prevention of pain in mammals, in particularly in human beings, and also to a process for preparing these compounds.Type: GrantFiled: December 31, 2012Date of Patent: February 26, 2019Assignees: ECOLE NATIONALE SUPERIEURE DE CHIMIE DE CLERMONT FERRAND, UNIVERSITÉ CLERMONT AUVERGNEInventors: Sylvie Ducki, Khalil Bennis, Alain Eschalier, Jérôme Busserolles, Florian Lesage, Nuno Rodrigues, Delphine Vivier
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Patent number: 10214477Abstract: The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.Type: GrantFiled: April 26, 2017Date of Patent: February 26, 2019Assignee: Oryzon Genomics S.A.Inventors: Alberto Ortega Muñoz, Matthew Colin Thor Fyfe, Marc Martinell Pedemonte, Maria de los Àngeles Estiarte Martinez, Nuria Valls Vidal, Guido Kurz, Julio Cesar Castro Palomino Laria
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Patent number: 10214478Abstract: The present invention relates to amantadine nitrate compounds having neural protective effect, and preparation method and medical use thereof. The compounds have the structure of the general formula (I). The compounds have multifunctional mechanisms, including inhibiting NMDA receptors, releasing NO, inhibiting calcium influxes, and having protective effects on cells particularly neurocytes. The compounds can be used in the preparation of medicaments having a cellular protective effect, for prevention or treatment of the diseases related to such as NMDA receptors and elevation of calcium anions in cells, including the diseases related to neurodegeneration such as Alzheimer's disease, Parkinson's disease, cerebral paralysis and glaucoma, and the diseases related to cardio-cerebral-vascular system such as Parkinson's syndrome combined with cerebral arteriosclerosis, as well as respiratory tract infections caused by influenza virus.Type: GrantFiled: November 28, 2016Date of Patent: February 26, 2019Inventors: Yuqiang Wang, Zheng Liu, Pei Yu, Yewei Sun, Zaijun Zhang, Gaoxiao Zhang, Luchen Shan, Peng Yi, James Larrick
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Patent number: 10214479Abstract: The present invention relates to the reduction of polycyano compounds to produce polyamines, in particular diaminoacetal and diaminoketal compounds, and their use as curing agents in epoxy resin compositions. The reduction with molecular hydrogen can be carried out using a metal catalyst selected from GROUP VIII and a catalytic promoter. The reduction can include anhydrous or aqueous ammonia. The reaction can be carried out in continuous and batch modes with catalyst and solvent recycling. The epoxy resin composition consisting of an epoxy resin and a polyamine curing agent that can be used in fiber-reinforced composite materials, coating materials, and the like.Type: GrantFiled: January 3, 2017Date of Patent: February 26, 2019Assignee: Connora Technologies, Inc.Inventors: Szymon Kosinski, Stefan J. Pastine
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Patent number: 10214480Abstract: Provided is a synthesis process for a chiral cyclopropyl ethynyl tertiary alcohol compound, where a chiral amino alcohol or a chiral amino diol is reacted in the presence of an alkaline reagent and a salt to obtain an optically active propynyl alcohol compound. In particular, the process includes (1) reacting cyclopropyl acetylene with a chiral inducing agent, a chiral auxiliary reagent and zinc halide in an organic solvent in the presence of an alkaline reagent and a sulfonate or a sulphinate to obtain a first reaction mixture; (2) reacting the resultant first reaction mixture with 5-chloro-2-aminotrifluorobenzophenone to form (S)-2-amino-5-chloro-?-cyclopropyl acetylene-?-trifluoromethylbenzyl alcohol. The process avoids an organic zinc reagent and a Grignard reagent, and has the advantages of safe production, an environmentally friendly route, low production costs, a high resultant product yield, a high chiral ee value and is suitable for industrial production.Type: GrantFiled: October 23, 2015Date of Patent: February 26, 2019Assignees: Shanghai Desano Pharmaceutical Co., Ltd., Yancheng Desano Pharmaceutical Co., Ltd., Jiangsu Puxin Pharmaceutical Co., Ltd.Inventors: Nan Zhao, Fei Jiang
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Patent number: 10214481Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.Type: GrantFiled: May 8, 2017Date of Patent: February 26, 2019Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AITHORITYInventor: Esther Priel
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Patent number: 10214482Abstract: A compound of the general formula (I) in which R1, R2 and R3 are independently selected from C1-4-alkyl and C1-4-hydroxyalkyl; each R4 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; each R5 is independently selected from hydrogen, C1-4-alkyl and C1-4-hydroxyalkyl; m is 2, 3, 4 or 5; n is 2, 3, 4 or 5; and o is an integer from 0 to 10. A preferred compound of the formula (I) is 2-(2-tert-butylaminoethoxy)ethylamine. Absorbents comprising a compound of the formula (I) have rapid absorption of carbon dioxide from fluid streams and are also suitable for processes for the simultaneous removal of H2S and CO2, where given H2S limits have to be observed but complete removal of CO2 is not required.Type: GrantFiled: August 20, 2015Date of Patent: February 26, 2019Assignee: BASF SEInventors: Thomas Ingram, Marion Da Silva, Georg Sieder
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Patent number: 10214483Abstract: The present invention provides a titanium-silicalite molecular sieve and a method for preparing the same. The method includes the steps of preparing a mixture of a titanium source, a silicon source, a metal source selected from IIA to IVA elements and a template agent; heating the mixture to form a gel mixture; heating the gel mixture in a water bath; and calcining the gel mixture after the gel mixture in the water bath to form the titanium-silicalite molecular sieve. The present invention further provides a method for preparing cyclohexanone oxime by using the titanium-silicalite molecular sieve as the catalyst which results in high conversion rate, high selectivity and high usage efficiency of hydrogen peroxide.Type: GrantFiled: August 19, 2016Date of Patent: February 26, 2019Assignee: China Petrochemical Development CorporationInventors: Ya-Ping Chen, Cheng-Fa Hsieh, Pin-To Yao, Chien-Chang Chiang
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Patent number: 10214484Abstract: The present invention relates to an improved method for preparing acrolein cyanohydrins from hydrocyanic acid and the corresponding acroleins. The method is characterized in that the acrolein cyanohydrins obtained have a very low hydrocyanic acid content or are free of hydrocyanic acid and are therefore particularly well suited as intermediates for the synthesis of glufosinates.Type: GrantFiled: March 27, 2018Date of Patent: February 26, 2019Assignee: Evonik Degussa GmbHInventor: Marianne Omeis
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Patent number: 10214485Abstract: The invention relates to a method of reprocessing alkanesulfonic acid employed in a chemical process as an agent, catalyst or solvent and comprising the steps of: (a) removing an alkanesulfonic acid-comprising stream from a reaction mixture generated in the chemical process, (b) feeding the alkanesulfonic acid-comprising stream into a melt crystallization as the starting melt to form crystals of the alkanesulfonic acid, of hydrates of the alkanesulfonic acid or of a mixture of both suspended in mother liquor, (c) performing a solid-liquid separation to remove the crystals from the mother liquor, (d) optionally washing the crystals to remove mother liquor adhering to the crystals, (e) recycling the washed or unwashed crystals removed from the mother liquor into the chemical process.Type: GrantFiled: November 8, 2016Date of Patent: February 26, 2019Assignee: BASF SEInventors: Jan Spielmann, Michael Koch, Juergen Wortmann, Sabine Weiguny, Feelly Ruether, Robert Sengpiel
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Patent number: 10214486Abstract: Disclosed are processes and systems for oxidizing cycloalkylbenzene such as cyclohexylbenzene to make an oxygenate such as a hydroperoxide thereof. A liquid distributor having multiple liquid ingress ports is used for supplying a cycloalkylbenzene-containing liquid into an oxidation reactor in the form of liquid streams forming part of the reaction medium. A gas distributor distributing an O2-containing gas into the reaction medium in the form of gas streams is preferably located below the liquid distributor. Preferably the gas bubbles upwards in the reaction medium. The agitation and mixing provided by the liquid streams, gas streams/bubbles result in sufficient homogeneity of cycloalkylbenzene concentration, cycloalkylbenzene hydroperoxide concentration, dissolved oxygen concentration, and temperature in the liquid phase.Type: GrantFiled: June 3, 2016Date of Patent: February 26, 2019Assignee: ExxonMobil Chemical Patents Inc.Inventors: Yesim Igci, Bryan A. Patel, Min Chang
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Patent number: 10214487Abstract: The invention provides indole-4,7-dione derivatives useful for the treatment of diseases in a mammal, pharmaceutical compositions containing the same and methods of using the same in the treatment of cancer and neoplastic diseases including human solid tumors and other mammalian tumors.Type: GrantFiled: February 27, 2006Date of Patent: February 26, 2019Assignee: The Regents of the Univeresity of Colorado, a body corporateInventors: David Ross, Philip Reigan, David Siegel, Christopher J. Moody, Marie A. Colucci, Donna Dehn
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Patent number: 10214488Abstract: Provided are methods and/or systems to convert sulfide intermediates to sulfilimines using a series of continuous loop reactors instead of a batch reactor. The advantages of the methods and systems provided include improved total yield, improved heat management, improved phase mixing, and/or improved volume management.Type: GrantFiled: June 16, 2017Date of Patent: February 26, 2019Assignee: Dow AgroSciences LLCInventors: Kurt D. Olson, Aaron A. Shinkle
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Patent number: 10214489Abstract: The present invention provides a spiro compound of General Formula 1, and use thereof in the fields of electronic materials, fine chemistry, and medical science. Further, the present invention also provides an organic electroluminescence device fabricated by using the spiro compound of General Formula 1. When used in an organic electroluminescence device, the compound of General Formula 1 provided in the present invention is capable of reducing the drive voltage, and increasing the luminous efficiency, brightness, thermal stability, color purity, and service life of the device.Type: GrantFiled: October 31, 2016Date of Patent: February 26, 2019Assignee: NANJING TOPTO MATERIALS CO., LTD.Inventors: Jin Woo Kim, Chao Qian, Jun Xu, Dening Wang
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Patent number: 10214490Abstract: This disclosure relates to picolinamides of Formula I and their use as fungicides.Type: GrantFiled: August 30, 2017Date of Patent: February 26, 2019Assignee: Dow AgroSciences LLCInventors: Zachary A. Buchan, Yu Lu, David M. Jones, Kevin G. Meyer, Chenglin Yao, Brannon Sam, Jeremy Wilmot
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Patent number: 10214491Abstract: The invention presents methods of identifying small molecule compounds that are activators of tumor suppressor protein p53 pathway, and its associated family members p63 and p73, function. The invention is further drawn to methods of killing tumor cells and treating cancers or other conditions requiring activation of the p53 family member pathways and DNA damage response pathways with the small molecules.Type: GrantFiled: February 4, 2014Date of Patent: February 26, 2019Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Marikki Laiho, Karita Peltonen