Abstract: High torque guidewires and methods for making and using them are provided. A guidewire may include an inner core wire movable relative to an outer jacket. The outer jacket includes proximal and distal ends, a lumen extending there between, thereby defining a longitudinal axis, and one or more helical slots adjacent the distal end. The core wire includes a proximal portion, a distal portion slidably received in the outer jacket lumen and terminating in a curved distal tip that extends from the outer jacket distal end, and one or more pins on the distal portion, each pin slidably received in a respective helical slot in the outer jacket such that axial movement of the core wire relative to the outer jacket causes the pin to slide within the helical slot and rotate the distal tip relative to the outer jacket distal end.

Abstract: A catheter includes a catheter body having a proximal end, a beveled distal end, and a lumen therethrough. The beveled distal end defines an elliptical port for releasing contrast or other media through the lumen and from the elliptical port. The catheter may also be used delivering devices or for aspirating or extracting materials from the vasculature or other body lumens. A fixed guidewire extends distally from the distal end of the catheter body, typically from the distal-most edge of the elliptical port. The fixed wire is typically malleable so that it can be manually formed into a desired shape. The elliptical port may be flat or concave.

Abstract: A catheter insertion device includes a housing, a needle, a catheter, a guidewire, and an actuator mechanism including a biasing member. The needle is attached to a needle carrier having a proximal end disposed in the housing, the needle having an insertion position and a retraction position with respect to the housing. The catheter is positioned coaxially around the needle. The guidewire has a distal end positioned in a lumen of the needle in a withdrawn position, the guidewire being translatable to an advanced position in which the distal end extends distally from a tip of the needle. The guidewire may include a distal end with a coiled configuration. Actuating the actuator mechanism releases the biasing member to simultaneously translate the needle and the guidewire, the needle from the insertion position to the retraction position, and the guidewire from the advanced position to the withdrawn position.

Abstract: A bulbous valvuloplasty balloon is described that maintains its bulbous shape in its final deployed configuration along with the method of use for post dilation of a TAVR device. The bulbous balloon has two larger diameter bulb segments located on each side of a smaller diameter waist and can be used to post dilate a TAVR device that has been implanted at the site of a stenotic aortic valve. The post dilation causes deformation of the underlying tissues residing outside of the TARV stent structure.

Abstract: A constraining structure for use with a balloon catheter includes multiple longitudinal struts and multiple expandable radial rings. The constraining structure can expand radially but may not expand substantially in the longitudinal direction. The constraining structure can have multiple compartments configured to expand independently of one another. Inflating the balloon catheter within the constraining structure can allow for dilation of the blood vessel in a pre determined topography.

Abstract: A dual chamber applicator includes an elongated tube having a sealed end and an open end, a first ampoule disposed in the elongated tube and containing a first composition including a pharmaceutically active agent and optionally a first volatile solvent, water, or a combination thereof, a second ampoule disposed in the elongated tube and containing a second composition including a resin based tincture, a second volatile solvent and water, and an applicator device provided at the open end of the elongated tube. The first composition is configured to combine with the second composition within the elongated tube to form a medicine to be delivered to a mucosal site or a skin site. The applicator device is configured to control flow of the medicine out of the open end of the elongated tube and deliver the medicine via topical, transdermal or transmucosal delivery.

Abstract: Disclosed herein are transdermal microneedling devices that generate and emit low RF energy. Such a microneedling device may comprise a drive motor, drive circuitry for controlling the drive motor, and a drive linkage located on the drive motor rotor. The microneedling device may also comprise a power source capsule comprising a battery and associated power management circuitry. Also included may be a needle cartridge coupled to the main body, and comprising a drive shaft and a needle unit coupled to a distal end of the drive shaft to move therewith, where the needle unit has at least one needle extending therefrom. The drive shaft may comprise a linkage member configured to engage the drive linkage of the drive motor, and be configured to be driven by the drive motor and thereby drive movement of the needle unit such that the at least one needle extends beyond and retracts within the distal end of the needle cartridge.

Abstract: A method of controlling a tattoo machine power supply (14), comprises detecting a user interaction with the tattoo machine power supply (14); based on said user interaction, generating an activation signal; wirelessly transmitting the activation signal; and setting the tattoo machine power supply (14) in an active state, in which it is responsive to remote control commands.

Abstract: A percutaneous connection device to be fixed in an osseous structure of a patient to connect an internal entity located inside the body of the patient to an entity external to said body, the device comprising a percutaneous socket having a first end comprising a percutaneous abutment and a second end opposite to the first end, an elongated extension member designed to be inserted within a hole created into the osseous structure, said extension member having a first end to be removably coupled to the second end of the socket and a second end opposite to the first end, an anchoring mechanism for anchoring the device to the osseous structure by osseointegration and a separate connection running through the device from the first end of the percutaneous socket to the second end of the extension member, and comprising at least a first connector arranged within the percutaneous abutment.

Abstract: A connection device includes a connection body which has a hose adapter and a connector piece for releasably fastening a further fluid conduit component or fluid storage component. The connection body is coaxially surrounded by a securing sleeve. The securing sleeve is axially securable on the connection body in two securing positions that are axially mutually spaced apart relative to a central longitudinal axis of the connection body. Rotatability of the securing sleeve is possible in a first securing position, and jamming of the securing sleeve on a hose portion that is plug-fitted onto the hose adapter is possible in a second securing position.

Abstract: A connector is disclosed, which includes a main body and a valve body. The main body can include a main line flow channel capable of circulating an infusion solution, and valve body arrangement portions and connecting to the main line flow channel. The valve body includes an operable and closable slit provided to a deformed portion. The valve body is provided along an opening/closing direction of the slit, and includes a guide portion configured to facilitate opening and closing of the slit, and a thickened portion protrusively formed so as to extend through near both ends in a longitudinal direction of the slit and on both sides of the guide portion.

Abstract: A device for cranial implantation includes a ferrule and a plate for placement in the ferrule. Furthermore, a neurological implant system includes a probe and a device for cranial implantation.

Abstract: An implantable hearing prosthesis, comprising an integrated integrity system. The integrity system is configured to measure one or more electrical characteristics of at least one component of the prosthesis, to evaluate the integrity of the prosthesis based on the measurements, and to perform at least one diagnostic operation based on the evaluation.

Abstract: A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.

Abstract: An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator. The nerve cuff may include a cuff body having a pocket or pouch for removably receiving the implantable device within. The nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve. Furthermore, the nerve cuff drives the majority of the current from the stimulation device into the nerve, while shielding surrounding tissues from unwanted stimulation.

Abstract: Leakage of signal between conduction paths of an implantable medical lead or lead and lead extension combination is detected. A stimulation signal is provided via one electrode. Two other electrodes sense the stimulation signal. A difference in amplitude of the two sensed signals is determined and based on this difference, leakage is detected. A sensing circuit may use differential amplification of the two signals and compare a resulting output signal to a leakage threshold. When the amplitude of the output signal exceeds the leakage threshold, then leakage is occurring between the conduction path providing the stimulation and one of the conduction paths used for sensing. Other techniques for determining leakage from the difference may also be used such as comparing the amplitudes of the two sensed signals and providing a value that is based on the comparison to indicate whether leakage is present.

Abstract: One aspect of the present disclosure relates to a system for electrical stimulation. A waveform generator can be configured to generate an electrical waveform. An electrode can be electrically coupled to the waveform generator and configured to deliver the electrical waveform to a nerve to reduce at least one reflex that affects a bodily function.

Abstract: A system and method for relieving hypertension includes an energy wave generator set an energy wave's frequency control mode for controlling and generating energy waves with correspond energy densities in multiple energy wave generation periods to effect on a body with hypertension, so as to relieve hypertension by the specific energy wave.

Abstract: Systems, devices and methods for averting imminent medical attacks comprise transcutaneous electrical and magnetic nerve stimulation devices using energy that is delivered non-invasively to the patient. One or more sensors detect physiological and/or environmental signals within a patient and the values of these signals are used to forecast an acute medical event, which can be treated via non-invasive nerve stimulation. The acute medical events may comprise, among others, bronchoconstriction, epileptic seizures, primary headache, such as migraine or cluster headaches, transient ischemic attack or stroke, onset of atrial fibrillation, myocardial infarction, and acute depression or anxiety.

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, a programmer has instructions that, in response to an input, select between a paresthesia-inducing electrical therapy signal having a frequency of less than 1.2 kHz, and a non-paresthesia-inducing electrical therapy signal having a frequency in a range from 1.5 kHz to 100 kHz.

Abstract: Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, a programmer has a computer-readable medium containing executable instructions in memory to, in response to an input, select between at least two therapy programs: a first having a frequency of less than 1,500 Hz, and a paresthesia-inducing amplitude between 3 mA and 10 mA; and a second having a frequency between 5 kHz and 15 kHz, and a non-paresthesia-inducing amplitude between 0.5 mA and 10 mA.

Abstract: Systems and methods for managing pain in a patient using an electrical waveform that link the modulation of a waveform parameter for different areas of a patient. One embodiment in a system for managing pain in a patient comprises an electric device configured to be implanted into the patient and including a plurality of electrodes having at least a first electrode associated with a first area of the patient and a second electrode associated with a second area of the patient. The system further includes an implantable device configured to be coupled to the electrode device and having a computer-operable medium programmed to change the waveform parameter applied to the first electrode and automatically set the waveform parameter applied to the second electrode based on a relationship between a first therapy range and a second therapy range of the waveform parameter.

Abstract: A method includes receiving sensor data at a processor from sensors of an external medical device. The sensor data corresponds to at least a first body parameter value for a patient and a second body parameter value for the patient. The method includes determining a first depression-indicative value based on the first body parameter value, a second depression-indicative value based on the second body parameter value, a depression detection value as a function of a first weight applied to the first depression-indicative value and a second weight applied to the second depression-indicative value, and a depression state based at least in part on a comparison of the depression detection value to one or more threshold values.

Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A titration process is used to gradually increase the stimulation intensity to a desired therapeutic level. This titration process can minimize the amount of time required to complete titration so as to begin delivery of the stimulation at therapeutically desirable levels.

Abstract: Systems and methods for treating arrhythmias are disclosed. In one embodiment an LCP comprises a housing, a plurality of electrodes for sensing electrical signals emanating from outside of the housing, an energy storage module disposed within the housing, and a control module disposed within the housing and operatively coupled to the plurality of electrodes. The control module may be configured to receive electrical signals via two or more of the plurality of electrodes and determine if the received electrical signals are indicative of a command for the LCP to deliver ATP therapy. If the received electrical signals are indicative of a command for the LCP to deliver ATP therapy, the control module may additionally determine whether a triggered ATP therapy mode of the LCP is enabled. If the triggered ATP therapy mode is enabled, the control module may cause the LCP to deliver ATP therapy via the plurality of electrodes.

Abstract: An apparatus for delivering an electrical microstimulator is provided. The apparatus comprises a handle having a handle body. An elongate delivery rod includes a delivery sheath for reciprocal movement with respect to the handle body. The delivery rod extends longitudinally from the handle body. A microstimulator docking feature is provided for selectively maintaining the electrical microstimulator on the delivery rod. The microstimulator docking feature includes at least one arm which engages the electrical microstimulator. An anchor tester is associated with the handle body for selectively sensing motion of the electrical microstimulator under influence of an applied predetermined longitudinal testing force. A method of delivering an electrical microstimulator to a target implant site of a patient's body is also provided.

Abstract: An Implantable Medical Device (IMD) is disclosed having a bi-directional short-range far-field Radio-Frequency (RF) data antenna, operable in accordance with a short-range RF standard such as Bluetooth for example. The antenna is neither located inside the conductive case of the IMD, nor in the non-conductive header of the IMD that includes the lead connectors. Instead, the antenna is outside of the case, proximate to and generally planar with a flat planar side of the case that faces outward of the patient when the IMD is implanted. Dielectric materials keep the antenna from shorting to the case and to the patient's tissue. Because the antenna is not located within the conductive case, data communications to and from the antenna are less subject to attenuation. Not locating the antenna in the header reserves room for the header's lead connectors, thus simplifying IMD design.

Abstract: An implantable device, such as a pacer, defibrillator, or other cardiac rhythm management device, can include one or more MRI Safe components. In an example, the implantable device includes a battery including a first electrode and a second electrode separate from the first electrode. The second electrode includes a first surface and a second surface. The second electrode includes a slot through the second electrode from the first surface toward the second surface. The slot extends from a perimeter of the second electrode to an interior of the second electrode. The slot is configured to at least partially segment a surface area of the second electrode to reduce a radial current loop size in the second electrode.

Abstract: A particular implantable device may include one or more antennas configured to receive a first far field radiative signal and a second far field radiative signal. The one or more antennas may be configured to receive the first far field radiative signal in a first frequency band and to receive the second far field radiative signal in a second frequency band. The implantable device may include a voltage rectifier configured to rectify the received first far field radiative signal and the received second far field radiative signal to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a therapy delivery unit powered by the charge storage element. The therapy delivery unit may be operative to deliver a therapy to a patient.

Abstract: One embodiment provides a power supply device for supplying power to a medical device main body implanted in a human body. The power supply device includes a power supply coil configured to supply power wirelessly to a power reception coil provided in the medical device main body from outside the human body through electromagnetic induction. And, the power supply coil includes: a cylindrical coil formed by winding a lead wire helically; and a ring-shaped member made of a magnetic material and is disposed so as to surround an outer circumference of the cylindrical coil.

Abstract: Methods, systems, and devices for signal analysis in an implanted cardiac monitoring and treatment device such as an implantable cardioverter defibrillator. In illustrative examples, captured data including detected events is analyzed to identify likely overdetection of cardiac events. In some illustrative examples, when overdetection is identified, data may be modified to correct for overdetection, to reduce the impact of overdetection, or to ignore overdetected data. New methods for organizing the use of morphology and rate analysis in an overall architecture for rhythm classification and cardiac signal analysis are also discussed.

Abstract: According to an example embodiment of the present invention, there is provided an apparatus comprising at least one receiver configured to receive signals relating to a position of a device relative to a head, at least one processing core configured to determine, at least in part based on the received signals, the position of the device relative to the head, to compare the position of the device relative to the head to information concerning a position corresponding to a maximal induced electric field, and to cause signals to be transmitted, and wherein the transmitted signals are configured to cause a display to indicate a deviation of the position of the device from the position corresponding to the maximal induced electric field.

Abstract: A dental device for treating dental infection includes a dental cast comprising at least one groove to receive teeth and/or gums of a dental arch of the patient; and at least one light diffusing fiber arranged on the dental cast around the at least one groove. The dental device is used in a photodynamic therapeutic system, in which a light source instrument emits light onto a photosensitizer applied in mouth of the patient. The dental device is optically coupled to the light source instrument. The light for treating dental infection of the patient is transmitted by the at least one light diffusing fiber of the dental device and activates the photosensitizer to produce free radicals or oxidants to destroy the bacteria and microbes causing dental disease.

Abstract: In one embodiment, radiotherapy treatment is provided to a target volume of a patient by configuring a multileaf collimator of a radiation treatment machine in a first orientation so as to form an actual aperture having a first orientation, delivering radiation to the target volume through the actual aperture while in the first orientation with a single pass along an arcuate path centered on the target volume, configuring the multileaf collimator in a second orientation so as to place the actual aperture in a second orientation that is different from the first orientation, and delivering radiation to the target volume through the actual aperture while in the second orientation with a single pass back along the arcuate path such that a relatively large cumulative dose of radiation is delivered to the target volume through a virtual aperture created by an area of overlap between the first and second actual aperture orientations.

Abstract: A cosmetic composition for caring for and/or making up the skin and/or the lips, containing, in a physiologically acceptable medium, includes at least: one active agent comprising at least one glycol with a C4-C16 hydrocarbon-based chain and/or a hydroxylated ester resulting from the esterification of polyol and/or of C4-C16 carboxylic acid(s), and one additional agent chosen from essential oils, agents for promoting capillary circulation and temperature regulators, and mixtures thereof.

Abstract: A configurable exhale system for a respirator has a first valve assembly disposed within a chamber which is configured to prevent air from flowing through the first valve assembly when an air pressure differential between an upstream side and a downstream side of the first valve assembly is below a first opening pressure. A second valve assembly is disposed within the chamber in fluid communication with the first valve assembly which is configured to prevent air from flowing through the second valve assembly when an air pressure differential between an upstream side and a downstream side of the second valve assembly is below a second opening pressure, which is greater than the first opening pressure. A bypass opening is positioned adjacent the second valve assembly configured to enable air to bypass the second valve assembly with a bypass member positioned adjacent to the bypass opening.

Abstract: A rope safety device (10,10-1) installed as a sub-roof element on a roof (T), a covering or a similar structure, comprising: a fixing and damping plate (11), perforated, fixed to the roof structure (T): and a rope (12) associated with the fixing and damping plate, wherein the rope (12) has an attachment portion (12a), in the form of an eyelet (12?), via which an operator can attach to the rope (12), so as to operate in a safe condition on the roof on which the device is installed: wherein the plate (11) has a configuration with one or more holes (13, 13b) used to insert the rope (12) and wherein the rope (12) is configured and set with respect to the plate, in whose holes (13b) is inserted, in such a way that the rope (12), when it is subject by the operator, attached to the same rope, to a given traction force (FT), slides (f) along a certain stroke (D) in the holes (13b) of the fixing and damping plate (11) before being retained by the latter.

Abstract: A fire-protection tape (22) to be placed into gaps (12) in walls or ceilings (10) of buildings has at least two plies (24a, 24b) composed of an intumescent material, wherein the plies (24a, 24b) have a first longitudinal edge (26a, 26b) on one outer side and a second longitudinal edge (28a, 28b) on an opposite outer side, in each instance, wherein the plies (24a, 24b) are flexibly connected with one another.

Abstract: A fire extinguishing system of an aircraft, including: a fire extinguishing nozzle device that is provided on an installation member forming a compartment of the aircraft; and a fire extinguishing pipe that is provided on a support structure supporting the installation member from a back side, and supplies a fire extinguishing agent to the fire extinguishing nozzle device. The fire extinguishing pipe is restrained to the support structure at a plurality of restraint positions. A holding device that holds the fire extinguishing pipe and is provided on the support structure is used at at least one of the plurality of restraint positions. The holding device includes a holding section that holds an outer periphery of the fire extinguishing pipe, and a disengaging section that enables disengagement of the fire extinguishing pipe.

Abstract: A fire suppression system for a plurality of enclosures in an aircraft comprises a plurality of bottles containing fire suppression agent, a temperature sensor and a pressure sensor on each bottle for measuring temperature and pressure data of the bottle contents, an addressable bottle valve on each bottle and a control unit. The control unit is configured to analyze the temperature and pressure data for each bottle to determine adequacy of fire suppression agent content for extinguishing a fire in a particular enclosure of the aircraft. The control unit is further configured to control the bottle valves independently by using the bottle valves' addresses, in order to manage the release of fire suppression agent.

Abstract: A nozzle positioning includes a primary pole, a grasping element supported on the upper end of the pole and configured to secure the pole to a surface, and a nozzle mount supported on the grasping element. The nozzle mount is configured to support a nozzle in a substantially horizontal position and to allow the nozzle to rotate about a longitudinal axis perpendicular to the horizontal upper surface of the grasping element. The grasping element is in the form of a hook configured to fit over a window sill or similar structure.

Abstract: A method to mitigate the consequences of a vapor cloud explosion due to an accidental release of a flammable gas in an open area, comprising: defining an hazardous area wherein an accidental release of flammable gas is likely to happen; receiving a signal from a detector device able to detect the presence of the flammable gas within the hazardous area, upon reception of a signal indicating the presence of the flammable gas within the hazardous area, generating a control signal to activate a release of a flame acceleration suppression product in the hazardous area, at a rate that is determined as a function of the volume of said hazardous area.

Abstract: A dry sprinkler assembly includes a housing, a sprinkler head assembly with a sprinkler head and a trigger assembly, and an actuator assembly. The actuator assembly has a sealing subassembly for sealing the inlet port of the housing and is operatively coupled to the trigger assembly such that the sealing subassembly releases the sealing of the inlet port in response to the trigger assembly releasing its closure at the outlet opening. The sealing subassembly moves in a linear path substantially parallel with the central longitudinal axis of the housing when releasing the sealing of the inlet port wherein the flow of fire suppressant through the inlet port and into the fluid flow passage is substantially unimpeded.

Abstract: A jump rope device including a rope portion, a first handle disposed on a first end of the rope portion, and a second handle disposed on a second end of the rope portion. A wireless speaker is disposed inside at least one of the first handle and the second handle. The wireless device is configured to connect to a music device.

Abstract: A mobile exercise device having a front wheel connected via a front wheel mount to a weight carriage that extends rearwardly from the front wheel mount. A weight loading member is mounted to the weight carriage and is operable to receive exercise weights and to support the exercise weights so that the exercise weights move as the weight carriage moves. A user engagement member includes a first end for engaging hips of a user and a second end for connecting to the weight carriage. Lifting the weight carriage via the user engagement member causes the weight loading member to be lifted and to rotate with respect to the front wheel.

Abstract: A shoulder end range of motion improving device has a linkage, the linkage including a first link member, a second link member supported on the first link member, the second link member configured for being secured to an arm of a patient and being rotatable about a second link axis for rotating the arm of the patient about a shoulder joint of the patient through an arm range of motion, the second link axis being displaceable into a selectable fixed position, the fixed position being maintained during rotation of the second link member, an actuator for rotating the second link member about the second link axis, and a controller controlling the actuator for selectively rotating the second link member about the second link axis through the arm range of motion.

Abstract: An exercise apparatus includes a frame, one or more pull cables running through cable guides to provide resistance exercise, and a winding/coiling mechanism for providing variable resistance to the one or more pull cables. A resistance power shaft is engageable with a winding shaft and effective for turning the winding shaft upon rotation of the resistance power shaft. A coupling effective to temporarily disengage the winding/coiling mechanism from a resistance power mechanism, and thus to allow the one or more pull cables to be wound or unwound at a rate different from a rate at which a motor is running may also be included. A cable management spring to bias the one or more pull cables toward a wound condition may be used. A computer/processor may be used to control a resistance force applied to the one or more pull cables and/or to record exercise results.

Abstract: The present disclosure contemplates a portable strength-training apparatus, system, and method for conducting strength-training exercises using resistance bands. The apparatus of the present disclosure can serve as an anchor while conducting the strength training exercises using the resistance bands. The apparatus and system of the present disclosure can allow for safely performing the strength-training exercises at varying resistance levels while allowing exercises at any angle. The apparatus, system, and method of the present disclosure may allow a user to strength train the user's entire body with the resistance bands. The apparatus and system of the present disclosure may include a base platform with base attachment mechanisms that can be coupled with the resistance bands which are in turn coupled with human interface mechanisms such as grips, wraps, or bars.

Abstract: An exercise training device includes a housing portion extending between a first end and a second end. The housing portion defines an internal bore. A biasing device is disposed within the internal bore. A first gripping portion is received within the internal bore through the first end of the housing portion. The first gripping portion is attached to a first biasing end of the biasing device. The first gripping portion is gripped by a user. A second gripping portion is received within the internal bore through the second end of the housing portion. The second gripping portion is attached to a second biasing end of the biasing device. The second gripping portion is gripped by the user. In response to a pressure applied, the biasing device and the housing portion are movable from an unflexed position to a flexed position.

Abstract: An article (101) is provided which comprises a body (103) having an interior volume (113), and a collapsible inlet (105) which is in open communication with said interior volume and which is movable from a first position in which it extends from said body, to a second position in which it extends into said internal volume.