Abstract: The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.

Abstract: The present disclosure provides antibodies that specifically bind to Mer Tyrosine Kinase (MERTK) (e.g., human MERTK, or both human and mouse MERTK) and compositions comprising such antibodies, wherein said antibody agonizes MERTK signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to MERTK and agonizes MERTK signaling on endothelial cells.

Abstract: The present disclosure relates to therapies for the treatment of tumor, autoimmune diseases, or other diseases. In some embodiments, the present disclosure can relate to subject-specific selection of humanized antibodies targeting clonal lineage specific marker proteins.

Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of penetrating cells via an ENT transporter, such as humanized antibodies. The disclosure also provides conjugates comprising the antibodies or antigen-binding fragments and a heterologous agent. The disclosure further provides methods for making and using the antibodies, antigen-binding fragments and conjugates, including humanized antibodies.

Abstract: The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

Abstract: The present invention relates to a downstream industrial method of purifying chondroitin sulphate obtained from animal cartilage, which produces a product fully compliant with the specifications required for the use of said compound in the pharmaceutical field.

Abstract: A composite is disclosed. The composite comprises a first conjugate of a polymer and a first phenol-containing moiety, and a second conjugate of a gelatin or collagen and a second phenol-containing moiety, wherein the polymer is selected so that the first conjugate is less cell-adhesive than the second conjugate, at least one of the first and second conjugates is crosslinked to form a matrix, and the composite comprises discrete regions that are rich in one of said first and second conjugates. A method of forming such composite is also disclosed. The method comprises mixing precursors for the first and second conjugates in a solution for forming said composite, and dispersing a catalyst in the solution to catalyze crosslinking of at least one of the first and second conjugates to form the matrix. The composite may be used to grow cells.

Abstract: A method for transitioning a gas phase polymerization reactor between metallocene catalysts is provided. The method comprises first reducing the superficial gas velocity and increasing the height of the fluidized bed within the reactor prior to stopping a feed comprising a first metallocene catalyst. The method further comprises introducing a first polymerization neutralizer to the reactor, wherein the first polymerization reactor does not comprise water, and then introducing a second polymerization neutralizer to the reactor, wherein the second polymerization neutralizer is different from the first polymerization neutralizer. After this, the method comprises purging the reactor with an inert gas and then introducing a feed comprising a second metallocene catalyst to the reactor.

Abstract: A composition for the immediate stopping of a free-radical polymerization comprises a) an inhibitor for the free-radical polymerization selected from among phenothiazines, b) an aprotic solvent and c) an ionic liquid. It serves to stabilize free-radically polymerizable monomers against free-radical polymerization. For the immediate stopping of free-radical polymerizations, the composition is added to a free-radically polymerizing system.

Abstract: A solid catalyst component for the polymerization of olefins, made from or containing Mg, Ti and an electron donor of formula (I) where independently, Z is a bridging group, the R2 groups, equal to or different from each other, are hydrogen or a C1-C20 hydrocarbon radicals, m is a number satisfying the valences of Z and n is an integer ranging from 1 to 10, R1 and R4 are selected from C1-C15 hydrocarbon groups, optionally containing a heteroatom selected from halogen, P, S, N, O; and R3 group, is hydrogen or R4 groups.

Abstract: Provided is a method of forming a polymer, comprising (a) providing a reaction mixture comprising (i) one or more vinyl monomers, (ii) one or more pH-sensitive inhibition systems, (iii) one or more initiators, and (iv) water; (b) establishing conditions in said reaction mixture such that a free radical polymerization of said vinyl monomer occurs at a location, and (c) after steps (a) and (b) and prior to completion of said free radical polymerization, changing the pH of said reaction mixture to increase the rate of generation of said free radical polymerization at the location of said free radical polymerization.

Abstract: Methods for treating solid metallocene compounds that are exposed to air are disclosed. These methods include a step of contacting the exposed solid metallocene compound with a purging gas stream containing an inert gas, and optionally, subjecting the exposed solid metallocene compound to a sub-atmospheric pressure.

Abstract: A catalyst system is provided which comprises a solid support material having, on its surface, one or more catalytic transition metal complex wherein the solid support material comprises SiO2@AMO-LDH microspheres having the formula I: (i) wherein, Mz+ and M?y+ are two different charged metal cations; z=1 or 2; y=3 or 4; 0<x<0.9; b is 0 to 10; c is 0.01 to 10, preferably >0.01 and <10; p>0 q>0; Xn? is an anion with n>0, preferably 1?5a=z(1?x)+xy?2; and the AMO-solvent is an 100% aqueous miscible organic solvent. Preferably, M? in the formula I is Al. Preferably, M in the formula I is Li, Mg or Ca. The catalyst system has use in the polymerization and/or copolymerization of at least one olefin to produce a homopolymer and/or copolymer.

Abstract: Phenolate ligands and transition metal complexes are disclosed for use in alkene polymerization, with optional chain transfer agent, to produce polyolefins.

Abstract: A process for the preparation of high purity propylene polymers carried out in the presence of a catalyst comprising the product obtained by contacting: (a) a solid catalyst component comprising Mg, Ti and at least a first internal electron donor compound (1ID) selected among the succinates and a second internal electron donor compound (2ID) selected among the 1,3-diethers, wherein the molar ratio of first internal donor over second internal donor 1ID:2ID is comprised between 4:6 and 9:1, with (b) an organo-aluminum compound, and optionally with (c) an external electron donor compound, said process being carried out at a temperature equal or higher than 78° C. and by employing a molar ratio of organo-aluminum compound over solid catalyst component (b):(a) of lower than 5.

Abstract: The invention relates to a process for the preparation of a particulate ultra high molecular weight polyethylene (pUHMWPE copolymer, comprising the steps of preparing a magnesium containing carrier, loading the carrier with a organometallic compound forming a supported catalyst and contacting the supported catalyst with ethylene and at least one olefinic co-monomer under polymerization conditions, wherein the organometallic compound is of the formula R33P?N—TiCpXn.

Abstract: A catalyst system for polymerizing olefin-based polymers and interpolymers is disclosed. The catalyst system may include a supported chromium catalyst and a Ziegler-Natta catalyst comprising a bulking agent, Mg, and Ti. The Ziegler-Natta catalysts in catalyst systems disclosed herein run exceptionally well without addition of excessive amounts of co-catalyst, thus allowing for use of chromium based supported catalysts that would otherwise be overwhelmed by aluminum alkyl. Further, embodiments disclosed herein may be run without an internal electron donor, and the lack of an internal electron donor in the system also prevents poisoning of the chromium catalysts by the internal electron donor. By including or co-feeding a chromium based catalyst with these Ziegler-Natta catalysts, it has been found that the molecular architecture of the resulting polyolefins, such as polyethylenes, may provide for resins with excellent processing properties.

Abstract: This invention provides activator precursor compositions and activator compositions. The activator precursor compositions are formed from a support material, a linking compound, and polyfunctional compounds having at least two aromatic groups in which at least two of said aromatic groups each has at least one polar moiety thereon. The activator compositions are formed from a support material, a linking compound, an aluminoxane, and a polyfunctional compound having at least two aromatic groups in which at least two of said aromatic groups each has at least one polar moiety thereon. Also provided are catalyst compositions, processes for forming catalyst compositions, and polymerization processes utilizing the catalyst compositions of this invention.

Abstract: Provided are a metallic crosslinking coagent, preparation methods thereof, and a resin composition comprising the metallic crosslinking coagent. With the active-hydrogen containing organic phosphorus compound group and metallophilic acrylate group, the metallic crosslinking coagent provides both stabilizer and flame-retardant effects, enhances the crosslinking efficiency of the resin composition, and improves the compatibility between flame retardant and the polymer. Accordingly, the metallic crosslinking coagent is effective to improve the mechanical properties of the application material and to develop a safe and environmentally friendly flame retardant material.

Abstract: A method is provided to control the short chain branching (SCB) distribution of an ethylene-butene (EB) polyethylene resin that is prepared in a gas phase polymerization process using a specific type of magnesium-titanium Ziegler Natta catalyst. The method allows the level of short chain branching to be increased in the low molecular weight fraction of the resin by increasing the polymerization residence time. The polymers that are produced in accordance with this invention may be useful for the preparation of cast films and blown films, especially for stretch film applications.

Abstract: A copolymer including ethylene units and units of one or more C3-10 alpha-olefins. The copolymer has a number average molecular weight of less than 5,000 g/mol, as measured by GPC. The ethylene content of the copolymer is less than 80 mol %. At least 70% of molecules of the copolymer have an unsaturated group, and at least 70% of said unsaturated groups are located in a terminal vinylidene group or a tri-substituted isomer of a terminal vinylidene group. The copolymer has a crossover temperature of ?20° C. or lower and/or a certain ethylene run length. Also disclosed are a method for making the copolymer and polyolefins plasticized with 1-40 wt % of the copolymer.

Abstract: This vinyl polymer powder, which contains a vinyl polymer, has a glass transition temperature of at least 0° C. (where if there are a plurality of glass transition points, all of the glass transition temperatures are at least 0° C.), has no greater than 350 ppm of the total content of magnesium ions, calcium ions, aluminum ions, barium ions, and zinc ions, has no greater than 100 ppm of the content of ammonium ions, has an acid number of no greater than 2.5 mgKOH/g, and has a bulk density of 0.10-0.60 g/cm3.

Abstract: An (ethylene, vinyl acetal) copolymer includes (i) a plurality of ethylenic moieties A having a structure according to the formula: wherein R2 and R3 independently represent hydrogen, a halogen, an optionally substituted linear, branched or cyclic alk(en)yl group, or an optionally substituted aromatic or heteroaromatic group; (ii) a plurality of acetal moieties B having a structure according to the formula: wherein L1 represents a divalent linking group; X=0 or 1; and R1 represents an optionally substituted aromatic or heteroaromatic group including at least one hydroxyl group; and (iii) a plurality of acetal moieties C and/or moieties D which are different from the acetal moieties B, and which include at least one nitrogen atom.

Abstract: The present invention is a composition comprising a stable aqueous dispersion of polymer particles comprising structural units of a phosphorus acid monomer or a salt thereof and structural units of a photoinitiator monomer. Gloss retention of paints containing the latex described herein is markedly improved over paints that do not have photoinitiator chemically bound to the latex particles.

Abstract: Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

Abstract: A method of forming a patterned polymer layer on a substrate and a substrate having a polymer layer formed by the method. The method includes providing a substrate comprising a first surface having a first surface energy and a pattern located on the substrate forming a second surface having a second, lower surface energy than the first surface, and selectively depositing a polymeric layer onto the first surface using a monomer material in an initiated chemical vapor deposition process, wherein the initiated chemical vapor deposition process is operated under supersaturation conditions during the deposition process.

Abstract: A contact lens is provided as hydrate of a copolymer of at least three components including (I) both terminal-polymerizable silicone oligomer exhibiting viscosity of at least 200 mPa·s at room temperature, (II) a hydrophilic monomer component having ethylenically unsaturated group, and (III) a hydrophobic monomer component having molecular weight of at most 700, wherein the lens exhibits an elastic-modulus ratio determined as ratio of a rupture elastic modulus to an initial elastic modulus in range of 0.8-1.2. The contact lens is transparent and by combination of high oxygen permeability and balance between softness and mechanical properties. The lens is produced through a process including steps of stirring material-liquid including at least three components of the above-mentioned (I), (II) and (III) under stirring power of 5-10000 W/m3 per unit volume of the material-liquid for at least 10 minutes, and injecting stirred material-liquid into a lens mold to polymerize material-liquid.

Abstract: Disclosed herein a composition comprising a urethane of the FIG. 3; where hydroxyl or amine linkages on the urethane of the FIG. 3 are functionalized with molecules that contain fluorine atoms, phosphorus atoms, sulfur atoms, unsaturated carboxylic acids, derivatives of unsaturated carboxylic acids, or combinations thereof. Disclosed herein too is a composition comprising a urethane of the FIG. 3; where hydroxyl or amine linkages of the urethane of the FIG. 3 are functionalized with molecules that contain fluorine atoms, phosphorus atoms, sulfur atoms, unsaturated carboxylic acids, derivatives of unsaturated carboxylic acids, or combinations thereof; and a polymeric resin.

Abstract: Provided are [1] a furan resin comprising a repeating unit represented by the following general formula (1); and [2] a method for producing a furan resin, comprising reacting a specific furan compound and a specific carbonyl compound in the presence of an acid catalyst: wherein R1, R2, R3 and R4 each independently represent a hydrogen atom, or an organic group having 1 to 8 carbon atoms which may contain a hetero atom; and R1 and R2, and R3 and R4 may be connected to each other to form a cyclic structure.

Abstract: A self-healing hydrophobic epoxy resin composition is provided. The self-healing epoxy resin composition comprises an epoxy resin component and a hardener component, the hardener component comprises at least 0.1 weight % of a modified epoxy resin hardener. The modified epoxy resin hardener is a reaction product of an amino modified oligomericsiloxane and a carboxylic acid anhydride. A process for preparing the modified epoxy resin hardener is also disclosed.

Abstract: An epoxy resin composition including A) at least one epoxy compound and B) a hardener composition including B1) 0.1%-100% by weight of 2-(3-(aminomethyl)-3,5,5-trimethylcyclohexyl)propane-1,3-diamine, and B2) 99.9%-0% by weight of at least one further diamine and/or polyamine, where the stoichiometric ratio of the epoxy groups of A) and the number of active hydrogen atoms of the functional groups of B) varies from 1:2 to 2:1.

Abstract: In one aspect, the present invention provides catalysts for the carbonylation of heterocycles. The inventive catalysts feature metal-ligand complexes having cationic functional groups tethered to the ligand, wherein the tethered cationic groups are associated with anionic metal carbonyl species. The invention also provides methods of using the inventive catalysts to affect the ring opening carbonylation of epoxides.

Abstract: Provided is a polycarbonate resin molding material, including an aromatic polycarbonate resin (A), in which the polycarbonate resin molding material has: a content of o-hydroxyacetophenone measured by a predetermined method (1) of 1 ppm by mass or less; and a YI value measured by a predetermined method (2) of 1.21 or less.

Abstract: The invention relates to a monofunctional or multifunctional acrylated or methacrylated urethane oligomer where said urethane bond is obtained without use of isocyanate and by the carbonate-amine reaction between a cyclic carbonate and a monoamine or polyamine, with subsequently the conversion of the hydroxyls in the ? position with respect to the urethane bond into ester-acids by reaction with a cyclic anhydride, which reaction is followed by the conversion of said acid functional groups into acrylated or methacrylated end groups by reaction with a polyepoxide compound in the presence of acrylic or methacrylic acid. The invention also relates to a preparation process. Said oligomer is used as crosslinkable binder for a functionality of at least 2 in coating, molding, leaktightness agent or sealing compositions or, if monofunctional, as macromonomer in polymerizable compositions for the production of grafted polymers.

Abstract: A process for preparing polymeric, ionic compounds comprising imidazolium groups (polymeric, ionic imidazolium compounds for short) comprising reacting—an ?-dicarbonyl compound,—an aldehyde,—at least one amino compound having at least two primary amino groups (referred to as oligoamine),—if appropriate an amino compound having only one primary amino group (referred to as monoamine) and a—protic acid, wherein the molar ratio of the ?-dicarbonyl compound to the oligoamine is greater than 1.

Abstract: There is provided a photocurable and thermosetting resin composition which suppresses decrease of adhesive strength in a moisture resistance test of the cured resin composition, and has a sufficiently long pot life. The resin composition includes (A) an acrylic resin, (B) a multifunctional nitrogen-containing heterocyclic compound represented by a specific chemical formula, (C) a latent curing agent, (D) a radical polymerization inhibitor, and (E) an anionic polymerization retarder. The resin composition preferably further includes (F) a compound having a glycidyl group, other than the acrylic resin.

Abstract: Provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant amines and (ii) an acid. Also provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant acids and (ii) an amine. The compositions are useful inter alia for chemical or oil spill cleanup, drug delivery systems, transparent films, adhesives, binding agents, conductors, membranes, cross-linking agents, or opticoelectronic applications. Also provided are methods for making the compositions of the invention, as well as a battery and a composition for controlled release of a compound, each comprising a composition of the invention.

Abstract: This disclosure enables direct 3D printing of preceramic polymers, which can be converted to fully dense ceramics. Some variations provide a preceramic resin formulation comprising a molecule with two or more C?X double bonds or C?X triple bonds, wherein X is selected from C, S, N, or O, and wherein the molecule further comprises at least one non-carbon atom selected from Si, B, Al, Ti, Zn, P, Ge, S, N, or O; a photoinitiator; a free-radical inhibitor; and a 3D-printing resolution agent. The disclosed preceramic resin formulations can be 3D-printed using stereolithography into objects with complex shape. The polymeric objects may be directly converted to fully dense ceramics with properties that approach the theoretical maximum strength of the base materials. Low-cost structures are obtained that are lightweight, strong, and stiff, but stable in the presence of a high-temperature oxidizing environment.

Abstract: Oil soluble rheology modifying star macromolecules having a core and five or more polymeric arms, and compositions comprising the same. The polymeric arms on a star are covalently attached to the core of the star; each polymeric arm comprises one or more (co)polymer segments; and at least one polymeric arm and/or at least one polymeric segment exhibits a different solubility from at least one other polymeric arm or one other polymeric segment, respectively, in a reference liquid of interest. The oil soluble rheology modifying star macromolecules and compositions comprising the same for use in oil based systems.

Abstract: A hollow compact has a partition partitioning it into a first interior compartment sealed apart from a second interior compartment. The first compartment is charged with a first solvent, the second compartment with a second solvent. The solubility properties of the first and second solvent are chosen such that neither risks attacking and/or dissolving the compact. Conversely, the solubility properties of the first and second solvent are otherwise chosen such that the mixture of the two indeed possesses an independent set of solubility properties, whereby the mixture is indeed capable of attacking and dissolving the material of the compact. Wherein, breaching the partition allows the charges of the first and second solvents to mix and thereby form the mixture therebetween. That way, the compact might vanish by dissolving into the mixture solvent or else might more likely might dissolve into a nearly un-recognizable form of its former self.

Abstract: A resin composition includes a thermoplastic resin, a carbon fiber, a resin containing at least one of an amide bond and an imide bond and having such a melting temperature that a difference in melting temperature between the resin containing at least one of an amide bond and an imide bond and the thermoplastic resin is 90° C. or lower, and a compatibilizer.

Abstract: A process of providing matrix-bonding abrasion resistant CNTs (MBARCs) includes reacting functionalized carbon nanotubes (f-CNTs) and Janus particles, wherein each of the Janus particles is a silica particle having a surface with a first portion containing a CNT-bonding functionality and a second portion containing a matrix-bonding functionality. The CNT-bonding functionality may include, for example, one or more hydroxyl groups. The matrix-bonding functionality may be, for example, selected from a group consisting of vinyl functionalities, amine functionalities, epoxy functionalities, allyl functionalities, acrylate functionalities, sulfur functionalities, isocyanate functionalities, halogen functionalities, and combinations thereof. In some embodiments, the MBARCs are processed to produce fibers that, in turn, may be blended into a polymeric resin to produce a fiber reinforced polymer composite.

Abstract: This specification describes an ion exchange membrane and a method of making it. The membrane may be used, for example, in an electrodialysis module or electrochemical cell. The membrane comprises an ion exchange polymer and inorganic particles preferably linked to the ion exchange polymer. To make a membrane, inorganic particles are mixed into an ion exchange membrane pre-cursor. A polymerization initiator or catalyst is then added and the resulting mixture is placed in a form and cured. The inorganic particles may comprise, for example, an oxidized form of graphite such as graphite oxide. The ion exchange polymer may comprise an ionic monomer, containing a quaternary ammonium group for anion exchange or a sulfonate group for cation exchange, along with a crosslinking co-monomer containing polymerizable diacrylic functionalities. The membrane is self-supporting and can be made without a supporting fabric.

Abstract: A method for making a cured rubber sheet, the method comprising providing an uncured rubber sheet, where the uncured rubber sheet includes opposing planar surfaces, applying a curable coating composition to one planar surface of the sheet to form a layer of curable coating composition, subjecting the curable coating composition to curing conditions that cure the coating composition and thereby form a cured coating layer on the uncured rubber sheet, rolling the uncured rubber sheet having a cured coating layer onto itself to form a roll, and subjecting the roll to curing conditions that cure the uncured rubber sheet and thereby forms a roll of cured rubber sheet.

Abstract: The present application relates to a thermally expandable composition containing an endothermic chemical blowing agent, to shaped bodies containing said composition and to a method for sealing and filling cavities in components, for strengthening or reinforcing components, in particular hollow components, and for bonding movable components using shaped bodies of this type.

Abstract: A method of producing a polypropylene resin in-mold expanded product, includes: placing polypropylene resin particles obtained from a base material resin having a melting point of 140° C. to 150° C., the base material resin comprising: a polypropylene resin A comprising 3 weight % to 15 weight % of 1-butene and having a melting point of 130° C. to 140° C.; and a polypropylene resin B having a melting point of 145° C. to 165° C.

Abstract: A carbon black pellet comprising a plurality of agglomerates, aggregates, or primary carbon black particles and a binder including a hot-polymerized styrene-butadiene copolymer.

Abstract: Embodiments described herein relate generally to the production of graphene/polymer compounds. In some embodiments, a method for producing graphene/polymer compounds includes compounding graphene nanoflakes with non-conductive polymer hosts via electrospray coating techniques, taking advantage of the highly electrostatically chargeable properties of graphene to de-agglomerate and further exfoliate the graphene nanoflakes in-situ, and providing uniform and well-dispersed graphene nanoflake coating on various non-conductive polymer hosts, such as polymer fine particles, pellets, fibers, fabrics, non-woven, film, and formed articles. In some embodiments, the deposition of the graphene nanoflakes onto the hosts may be performed in combination with other components, such as but not limited to metal oxides and polymers.

Abstract: Block for use in a CAD/CAM system for the manufacture of a dental restauration, said block consisting of a thermoplastic polymer comprising PEEK including radiopaque particles selected from the group comprising BaZrO3, YbF3, Yb2O3, SrO, SrZrO3, SiO2—ZrO2, SiO2—Yb2O3, Lu2O3, LuF3.

Abstract: Powder mixture comprising: ?20-90 wt % of one or more powdered organic peroxides and ?10-80 wt % of one or more powdered filler materials, at least 60 wt % thereof being barium sulphate.