Abstract: The present invention is directed to a nucleic acid molecule comprising a polynucleotide sequence encoding a chimeric antigen receptor comprising (a) an anti-CLEC14A binding domain, (b) a transmembrane domain and (c) an intracellular signalling domain; wherein said anti-CLEC14A binding domain is capable of binding to the C-type lectin domain of CLEC14A. The invention further provides a chimeric antigen receptor encoded by the nucleic acid molecule, a vector comprising the nucleic acid molecule, a cell comprising the nucleic acid molecule, vector or CAR and the therapeutic use of the nucleic acid, vector or cell, particularly in treating CLEC14A expressing conditions.

Abstract: The present invention relates to an isolated antibody, which selectively binds to CLEC14A, wherein said antibody (a) comprises at least one heavy chain variable region that comprises three CDRs and at least one light chain variable region that comprises three CDRs, wherein said heavy chain variable region comprises:(i) a variable heavy (VH) CDR1 that has the amino acid sequence of SEQ ID NO. 105, preferably of SEQ ID NO: 2 or 42; (ii) a VH CDR2 that has the amino acid sequence of SEQ ID NO. 106, preferably of SEQ ID NO: 3 or 43; and/or (iii) a VH CDR3 that has the amino acid sequence of SEQ ID NO. 107, preferably of SEQ ID NO: 4 or 44; and/or wherein said light chain variable region comprises: (iv) a variable light (VL) CDR1 that has the amino acid sequence of SEQ ID NO. 108, preferably of SEQ ID NO: 6 or 46; (v) a VL CDR2 that has the amino acid sequence of SEQ ID NO. 109, preferably of SEQ ID NO: 7 or 47; and/or (vi) a VL CDR3 that has the amino acid sequence of SEQ ID NO.

Abstract: A method of treating a subject can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent, thereby disrupting KLRG1 signaling and activating CD8+ cytotoxic T and/or NK cells. A method of treating cancer can include administering to a subject in need thereof an effective amount of a killer cell lectin-like receptor G1 (KLRG1)/ligand binding agent. The methods can treat various cancers, for example melanoma, lung cancer, pancreatic cancer, glioma, breast cancer, ovarian cancer, metastatic breast cancer, and colon cancer.

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

Abstract: The present inventors succeeded in discovering specific amino acid mutations in the variable region, framework region, and constant region of TOCILIZUMAB, and this enables to reduce immunogenicity risk and the heterogeneity originated from disulfide bonds in the hinge region, as well as to improve antigen binding activity, pharmacokinetics, stability under acidic conditions, and stability in high concentration preparations.

Abstract: Certain R5 virus tropic HIV-1 subjects with viral load effectively conventionally controlled using HAART, i.e., subject having less than 50 viral copies/mL (<50 cp/mL), may be substantially more susceptible than others to effective monotherapy treatment using anti-CCR5 agents, e.g, PRO 140 mAbs. Certain HIV-1 subjects using PRO 140 monotherapy treatment may experience prolonged or unlimited time periods with actual undetectable viral loads, extremely low viral load counts ?1 cp/mL, very low, or low levels, or at conventionally undetectable levels, during monotherapy. Increasing dose amounts of anti-CCR5 agents, e.g., PRO 140, from 350 mg to 525 mg or 700 mg, may beneficially suppress a subject's viral load count before, during, and/or maintain effective prolonged monotherapy and may shorten the period of time necessary to determine if a subject will respond positively to PRO 140 monotherapy to less than eight (8) weeks. This invention includes protocols, methods, and kits.

Abstract: The invention provides methods for identifying an individuals with a disease or disorder who is less likely to respond to immunotherapy alone, the method comprising determining the presence of a stromal gene signature in a sample from the individual, said signature comprising one or more of FAP, FN1, MMP2, PDGFRB, or THY, wherein an increase in the level of expression of the one or more genes in the stroma gene signature relative to a median level identifies an individual for treatment with an immunotherapy and with a suppressive stromal antagonist. In some aspects, the invention provides methods for treating an individual displaying the stromal gene signature. In other aspects, the invention provides kits for determining the presence of a stroma gene signature in a sample from an individual.

Abstract: The present invention includes compositions and methods for the expression, secretion and use of novel compositions for use as, e.g., vaccine and antigen delivery vectors, to delivery antigens to antigen presenting cells. In one embodiment, the vector is an anti-CD40 antibody, or fragments thereof, and one or more antigenic peptides linked to the anti-CD40 antibody or fragments thereof, including humanized antibodies.

Abstract: The invention provides anti-Ly6E antibodies, immunoconjugates and methods of using the same.

Abstract: Described is a polypeptide comprising at least four domains specifically binding to a certain MHC peptide complex, the domains separated by linker amino acid sequences, thereby providing each domain with the capability to bind a separate MHC peptide complex, to a nucleic acid molecule encoding such a polypeptide, to a vector comprising such a nucleic acid molecule, to a host cell for expression of such a polypeptide, to a pharmaceutical composition comprising such a polypeptide, and to a kit of parts comprising at least two polypeptides of the disclosure.

Abstract: The invention provides methods of treating a subject having or at risk of cancer by administering a LIV-1 antibody drug conjugate and a chemotherapeutic.

Abstract: The invention provides improved compositions for adoptive cell therapies for cancers that express the glycoepitope STn on TAG-72.

Abstract: The present invention relates to a composition for regulating cell division by promoting or inhibiting the activity of FCHo1, and a method for regulating cell division using the same. The FCHo1 activity regulator of the present invention targets FCHo1 which functions as an important factor in cell division, and promotes or inhibits the activity thereof, thereby promoting cell division or inhibiting cell division, and thus can be effectively utilized for the treatment of diseases associated with cell division.

Abstract: Variant immunoglobulins with one or more amino acid modifications in the VH region that have altered binding to Staphylococcus aureus protein A, and methods of using the same are provided.

Abstract: Multi-specific molecules (e.g., engineered antibodies) that specifically bind to one or more targets, e.g., in a pH sensitive manner, are described, as well as methods of making and using such multi-specific molecules (e.g., engineered antibodies).

Abstract: The invention relates to isolated single-domain antibodies (sdAb) directed against von Willebrand Factor (VWF) D?D3 domain and chimeric polypeptides comprising thereof such as blood clotting factors and their uses in therapy such as in the prevention and treatment of hemostatic disorders. The invention also rotates to a method of extending or increasing half-life of a therapeutic polypeptide comprising a step of adding to the polypeptide sequence of said therapeutic polypeptide at least one sdAb directed against VWF D?D3 domain.

Abstract: Methods and pharmaceutical compositions for treating hemorrhage or bleeding are provided. The pharmaceutical compositions include an effective amount of an antifibrinolytic composition that reduces or inhibits hemorrhage or bleeding in a subject.

Abstract: Mechanically strong, biodegradable and reusable aerogels are disclosed, which can be made with a cross-linked cellulose ester, and which exhibit a low density and high porosity. The aerogels disclosed herein may be used as sorbent materials and can be modified with a hydrophobic and/or oleophilic agent.

Abstract: The present invention relates to a modification initiator and a modified conjugated diene-based polymer including the same, and more particularly, the present invention provides a modification initiator including a compound represented by Formula 1, a modified conjugated diene-based polymer including the same, and a method of preparing a modified conjugated diene-based polymer.

Abstract: The present invention relates to a hybrid supported metallocene catalyst and a polyolefin preparation method using the same. Using the hybrid supported metallocene catalyst can not only significantly reduce the amount of wax produced when polymerizing olefin monomers, but can also enhance the stress cracking resistance of the polyolefin that is prepared.

Abstract: The present invention relates to a method for recovering ethylene and a vinyl-comonomer that is capable of improving the rate of recovery of unreacted monomers remaining after polymerization of ethylene and a vinyl-based comonomer and increasing process efficiency through the reduction of costs. Specifically, the method for recovering ethylene and a vinyl-comonomer includes: a step of polymerizing ethylene and a vinyl-based comonomer at a pressure of 1500 bar or more; a step of depressurizing the product obtained in the polymerization step including an ethylene-vinyl-based comonomer polymer, ethylene, and a vinyl-based comonomer to 0.1 bar to 5 bar; a step of adding ethylene to the product obtained in the polymerization step under the pressure of 0.1 bar to 5 bar; and a step of separating ethylene and a vinyl-based comonomer from the product obtained in the polymerization step to which the ethylene is added.

Abstract: A cyanoethyl group-containing polymer and a preparation method thereof are provided. The cyanoethyl group-containing polymer is characterized by having very low contents of functional groups other than cyanoethyl groups.

Abstract: The present invention relates to a method for superabsorbent polymer that has a crosslinking density gradient increasing from the inside toward the outside, and thus, exhibits excellent properties with simultaneously improved centrifuge retention capacity and absorbency under load.

Abstract: The present disclosure relates to a preparation method of a porous super absorbent polymer including the steps of preparing a monomer neutralized solution by adding an internal cross-linking agent, an initiator, an inorganic filler, and a nonionic surfactant to a neutralized solution obtained by neutralizing at least 80 mol % of a water soluble ethylene-based unsaturated monomer containing acidic groups; high-shear mixing the monomer neutralized solution; preparing a hydrogel polymer from the high-shear mixed monomer neutralized solution by thermal polymerization or photopolymerization; and preparing a base resin powder by drying, pulverizing, and classifying the hydrogel polymer.

Abstract: Provided is a polymer flocculant which is capable of controlling the structure of a polymer that is a copolymerization product of a monomer (a) having a structure derived from formula (I) in each molecule and a water-soluble unsaturated monomer (b) having a polymerizable unsaturated bond in each molecule, and which has a branched or cross-linking structure, and is excellent in water-solubility and water dispersibility, In formula (I), R1 and R2 are respectively a linear or branched functional group configured of atoms selected from the group consisting of carbon not having a carbon-carbon unsaturated bond, oxygen, nitrogen, and hydrogen; W is a non-metal element of the group 15; X and Y are each a linear or branched functional group configured of atoms selected from the group consisting of carbon, oxygen, nitrogen, and hydrogen, and each have at least one carbon-carbon unsaturated bond, provided that X and Y have different structures; and Z is a chlorine ion, a bromine ion, or an iodine ion.

Abstract: The present invention relates to a method of preparing a thermoplastic resin. More particularly, the present invention relates to a method of preparing a thermoplastic resin, the method including a coagulation step of adding a water-soluble silicate compound and a metal salt coagulant to an ?-methylstyrene-vinyl cyan compound copolymer latex, followed by coagulation. In accordance with the present invention, a method of preparing a thermoplastic resin having superior heat resistance by adding an additive during coagulation and aging of ?-methylstyrene-vinyl cyan compound copolymer latex while controlling an addition time point of the additive is provided.

Abstract: To provide an ETFE film which is unlikely to wrinkle when stretched and retracted, and a method for producing the same.

Abstract: The invention relates to a method of making fluoropolymers without excessive degradation of the polymer backbone. The invention also relates to the fluoropolymers made by this method, and method of using the fluoropolymers.

Abstract: A disclosed binder composition comprises a copolymer which comprises a nitrile group-containing monomer unit, an acidic group-containing monomer unit and a basic group-containing monomer unit, wherein the proportion of the nitrile group-containing monomer unit in the copolymer is 70.0 mol % or more and 99.0 mol % or less, and wherein the total proportion of the acidic group-containing monomer unit and the basic group-containing monomer unit in the copolymer is 0.8 mol % or more and 10.0 mol % or less.

Abstract: The present invention relates to a method for preparing an aqueous dispersion of water-soluble polymers, which comprises a step (E) of radical polymerization, wherein the following are brought into contact in an aqueous medium (M) in which the synthesised polymer is not soluble: at least one ethylenically unsaturated monomer which is soluble in the aqueous medium (M); at least one source of free radicals; and a reactive stabiliser which comprises: a polymer chain (CP) which is soluble in the medium (M), a group (G) providing the radical polymerization of step (E) with a living and controlled nature, such as, for example, a group carrying a thiocarbonylthio —S(C?S)— group.

Abstract: The present invention aims to provide a photocurable resin composition capable of constituting a composition having high printability. The present invention relates to a photocurable resin composition containing (A) an allylic polymer produced by polymerization of an allylic compound represented by the following formula (I), and (B) a gelling agent, wherein R1 and R2 each represent H or CH3; X represents an a-valent group having an unsubstituted saturated or partially unsaturated four- to eight-membered cyclic structure; and a represents 2 or 3.

Abstract: A polymer resin comprising: (a) quantum dots, (b) a compound of formula (I) (I) wherein R1 is hydrogen or methyl and R2 is a C6-C20 aliphatic polycyclic substituent, and (c) a block or graft copolymer having Mn from 50,000 to 400,000 and comprising from 10 to 100 wt % polymerized units of styrene and from 0 to 90 wt % of a non-styrene block; wherein the non-styrene block has a van Krevelen solubility parameter from 15.0 to 17.5 (J/cm3)1/2.

Abstract: Provided is a polymerizable composition including a mixture of at least one monomer which is capable of undergoing radical polymerization and which bears at least one polymerizable function, of at least one flexible dormant polymer block capable of generating at least one radical, and at least one free-radical generator derived from the decomposition of a photoinitiator. The composition may be used as a component of an adhesive, coextrusion binder, varnish, coating, resin for impregnating fabrics or woven materials, a composition suitable for printing on a flexible support or a composition suitable for 3D printing, for example.

Abstract: The present invention relates to a polymer-graphene composite, in which a polymer has been introduced onto the surface of graphene while maintaining the structural features and mechanical properties of the graphene, thereby realizing an excellent dispersibility in an organic solvent, a method for preparing the same, and a polymer-graphene composite composition using the same.

Abstract: In certain non-limiting, aspects, the present invention relates to storage stable premixes of a polyol suitable for polyurethane or polyisocyanurate foam preparation having, at least, 1,1,1,4,4,4-hexafluoro-2-butene (1336mzzm) as the blowing agent and optional one or more additional additives and/or auxillary blowing agents in amounts suitable for polyurethane or polyisocyanurate foam preparation.

Abstract: Described herein are aqueous dispersions including multistage-prepared polymers of olefinically unsaturated compounds and to the preparation and use thereof, in particular in the field of automobile coating.

Abstract: A crystalline non-reinforced thermoplastic polyurethane composition having a high flexural modulus comprises 5% to 25% of a hydroxyl-functional polyol intermediate having a weight average molecular weight of 250 to 3000 and 75% to 95% hard segment comprising an unbranched, unsubstituted, linear chain diol and an aromatic isocyanate.

Abstract: A macromolecular photonic crystal material including an A block and a B block is disclosed. the A block comprises a crystalline polyhedral oligomeric POSS, the macromolecular photonic crystal material represented by the structural formula 1.

Abstract: The present invention provides novel methods and processes for polymerizing unsaturated substrates, such as alkyne bearing monomers, with arenes. The polymerizations are catalyzed by gold (Au) catalysts/complexes and/or other cocatalysts. The invention further provides novel structurally complex polymers prepared in high yield via an intermolecular polyhydroarylation mechanism. Such resulting products comprise oligomeric and polymeric materials with novel molecular architectures and microstructures, which subsequently impart unique properties. The invention includes both the synthesis methods and processes and the resulting compounds and compositions of matter.

Abstract: A polycarbonate resin has a structure represented by a formula (1) and a yellow index (YI) of 30 or less in a solid form,

Abstract: The present invention provides a process for preparing polyether carbonate polyols from H-functional starter substance, alkylene oxide and carbon dioxide in the presence of a DMC catalyst or in the presence of a metal complex catalyst based on the metals zinc and/or cobalt, wherein the carbon dioxide used has a purity of 99.5000% to 99.9449% by volume.

Abstract: The present invention provides a method for preparing a polycarbonate by removing a solvent from a polycarbonate polymerization solution without impairing the physical properties of the polycarbonate.

Abstract: Provided is an aromatic polycarbonate resin composition with high fluidity, particularly during low shear, and a good color. An aromatic polycarbonate resin composition including: an aromatic polycarbonate resin that has a structural unit expressed by general formula (1); a aliphatic cyclic carbonate that is expressed by general formula (2) and is included at a ratio of 10 ppm-10,000 ppm; an aromatic cyclic carbonate that is expressed by general formula (3); and at least one compound selected from the group consisting of compounds expressed by general formulas (4)-(6), wherein the total content of the aromatic cyclic carbonate and the compound(s) expressed by general formula(s) (4)-(6) is 0.1 mass %-2.0 mass % by bisphenol A-converted value.

Abstract: A cross-linked rubber obtained by cross-linking a polyether rubber composition containing a polyether rubber and a cross-linking agent, wherein the polyether rubber contains an epihalohydrin monomer unit and an ethylene oxide monomer unit and has a ratio of content of the ethylene oxide monomer unit of 50 to 80 mol % in a total monomer unit, and an acetone extraction amount when the cross-linked rubber is immersed in acetone at 23° C. for 72 hours is 3.5 wt % or less.

Abstract: The present invention relates to the purification of poloxamers to be used as cell culture media additives. Activated carbon can be used to remove hydrophobic high molecular weight components which reduce the efficacy of poloxamers as cell culture additives.

Abstract: A binder for an electrochemical element, comprising: a polymer having a carboxyl group and/or a salt thereof, a polymer having an amide group and/or an amide bond; or a polymer having a carboxyl group and/or a salt thereof and an amide group and/or an amide bond.

Abstract: Provided herein is a process for producing a polyamide (P) by reaction of a mixture (M) including at least one lactam (component (A)), at least one catalyst (component (B)), at least one activator (component (C)), and at least one oxazolidine derivative (component (D)). Further provided herein is the mixture (M) and the use of an oxazolidine derivative for increasing the crystallization rate of a polyamide (P). Also provided herein is the use of an oxazolidine derivative in a polyamide (P) for producing a molded article from the polyamide (P) for reducing the demolding time of the molded article and the use of an oxazolidine derivative for removing water from a reaction mixture (RM).

Abstract: The present invention relates to binder compositions with improved amine components, and a method of manufacturing a collection of matter bound by said binder compositions.

Abstract: Provided herein are polyimide dispersants, as well as methods for producing polyimide dispersants. The polyimides can be defined by the formula below wherein A, individually for each occurrence, represents a cyclic diimide moiety represented by the structure below where B represents a cyclic moiety substituted with a first cyclic imide group and a second cyclic imide group; Y, individually for each occurrence, represents a bivalent linking group; L, individually for each occurrence, is absent or represents a cyclic imide group; R, individually for each occurrence, represents a polymeric tail; and n is an integer from 1 to 20.

Abstract: Provided are: a cured film-forming composition whereby a underlayer film for image formation formed from the composition exhibits high liquid repellency (lyophobicity) and lyophilic/liquid-repellent properties of the underlayer film can be easily changed even when exposed to a low amount of ultraviolet radiation; and a cured film obtained using the composition. The cured film-forming resin composition is characterized by containing: a polymer comprising a structural unit derived from a first monomer having the structure of formula (1) as component (A); a polymer other than component (A), which is a polymer in which the content of fluorine relative to the overall weight of the polymer is lower than in component (A), as component (B); a photoacid generator as component (C); and a solvent. (In the formula, R1 denotes hydrogen or a methyl group, and R2 denotes a fluorine-containing group able to be detached together with the oxygen atom bonded to R2.