Patents Issued in March 26, 2019
  • Patent number: 10239807
    Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: March 26, 2019
    Assignee: SynAffix B.V.
    Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
  • Patent number: 10239808
    Abstract: A method is provided for removing THC from raw cannabis oil.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: March 26, 2019
    Assignee: Canopy Holdings, LLC
    Inventors: Jacob Black, Ryan Beigie, Alex Mateo
  • Patent number: 10239809
    Abstract: New methods of preparing bridged bi-aromatic ligands are disclosed. The methods employ direct di-ortho-lithiation of aromatic rings of bridged protected bi-aromatic diphenols. The ligands may be used to prepare transition metal compounds useful as catalysts in olefin polymerization.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: March 26, 2019
    Assignee: Univation Technologies, LLC
    Inventors: Catherine Anne Faler, C. Jeff Harlan, Kevin P. Ramirez
  • Patent number: 10239810
    Abstract: The process of the invention is a process for the production of an aldehyde from the corresponding alcohol comprising the steps of feeding to a reactor a feed stream comprising said alcohol and an oxygen-containing gas; reacting said alcohol in the gas phase with said oxygen-containing gas in said reactor in the presence of a catalyst comprising oxides of iron and molybdenum, wherein the process further comprises the step of adding water to said feed stream. The process is particularly useful for the production of formaldehyde by the oxidation of methanol.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 26, 2019
    Assignee: Johnson Matthey Public Limited Company
    Inventor: Johan Björn Mattias Holmberg
  • Patent number: 10239811
    Abstract: A process for producing reduced coenzyme Q10 includes removing moisture from an aqueous suspension including a reduced coenzyme Q10-containing microbial cell or a disrupted cell thereof such that a de-moisturized substance is obtained and in contact with an oxidizing atmosphere, and that an oxidized coenzyme Q10 is produced in an amount of 50 mass % or more relative to a total amount of the oxidized and reduced coenzymes Q10, and reducing the oxidized coenzyme Q10 outside a microbial cell such that a reduced coenzyme Q10 is recovered.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: March 26, 2019
    Assignee: KANEKA CORPORATION
    Inventors: Kento Kanaya, Hiroko Okatsu
  • Patent number: 10239812
    Abstract: Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing phenolics and ketones is included. The method can specifically include forming a reaction mixture comprising nanocrystalline cellulose (NCC) and water. The method can also include contacting the reaction mixture with a metal oxide catalyst at a temperature of 350 degrees Celsius or higher and a pressure of at least about 3200 psi to form a reaction product mixture. The reaction product mixture can include at least about 20 wt. % phenolics and at least about 10 wt. % ketones as a percentage of the total mass of nanocrystalline cellulose (NCC). Other embodiments are also included herein.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: March 26, 2019
    Assignee: SarTec Corporation
    Inventors: Ronald Leigh Fedie, Bingwen Yan, Larry C. McNeff, Peter G. Greuel, Clayton V. McNeff
  • Patent number: 10239813
    Abstract: The invention relates to a method for the production of calcium dipropionate by a batch process in a single pressure-resistant reaction vessel. The reaction vessel is charged with calcium oxide, calcium hydroxide, calcium carbonate or a mixture thereof. Then, pure high-concentrated propionic acid, preferably in a concentration of above 99% is added to the solid raw materials. The heat (up to 160° C.) and pressure (up to 10 bar) are retained in the reaction vessel and are subsequently used to discharge the reaction water after the complete amount of acid has been added. After a reaction time of 3 to 6 hours, pure calcium dipropionate with a water content of below 1% is obtained.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: March 26, 2019
    Assignee: Addcon Europe GMBH
    Inventors: Klaus Ederle-Lerch, Norman Killian, Bernd Kochannek, Hans-Jürgen Stüwe
  • Patent number: 10239814
    Abstract: A process for the purification of levulinic acid including the following steps: a. providing a composition 1, comprising at least 75 wt. % of levulinic acid; b. cooling composition 1 to at least one temperature Tc, wherein Tc is a temperature in the range 1.23*(W1)?104.5?Tc (° C.)?1.23*(W1)?89.5, wherein W1 is the weight % of levulinic acid in composition 1, to obtain a cooled composition 1; c. performing melt crystallization of composition 1 including the steps of: i. bringing the cooled composition 1 into contact with levulinic acid crystal seeds, ii. allowing the levulinic acid in composition 1 to crystallize at at least one temperature Tc to obtain crystals 1 and liquid 1, and iii. draining of liquid 1; d. optionally, treating crystals 1, after draining of liquid 1, by sweating, according to the following steps: i. heating the crystals 1 at a temperature between 5 and 40° C. to obtain crystals 2 and liquid 2, and ii. draining of liquid 2; e.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: March 26, 2019
    Assignee: GFBIOCHEMICALS IP ASSETS B.V.
    Inventors: Aris De Rijke, Rudy Francois Maria Jozef Parton, Donato Santoro, Barthel Engendahl
  • Patent number: 10239815
    Abstract: The objective of the present invention is to provide a method for efficiently producing acrylic acid while troubles not only in a waste oil handling after distillation of acrylic acid but also in a purification system of acrylic acid during distillation are reduced. The method for producing acrylic acid according to the present invention is characterized in comprising the step of supplying at least crude acrylic acid and an alcohol solvent to an acrylic acid distillation apparatus to distill acrylic acid, wherein a boiling point of the alcohol solvent is higher than a boiling point of acrylic acid by not lower than 50° C.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 26, 2019
    Assignee: NIPPON SHOKUBAI CO., LTD.
    Inventors: Toyofumi Sakai, Masashi Mukae, Yasutaka Takemoto
  • Patent number: 10239816
    Abstract: The invention is directed to a process for recovering/purifying (meth)acrylic acid which does not use azeotropic solvent and is based on the use of two columns for purifying a reaction mixture comprising (meth)acrylic acid. The process according to the invention includes a dry vacuum pump condensation system, which makes it possible to reduce the amount of final aqueous discharges.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: March 26, 2019
    Assignee: Arkema France
    Inventors: Sandeep Jain, Christian Lacroix, Michel Jean Fauconet
  • Patent number: 10239817
    Abstract: The (1R,3R)- or (1S,3S)-enantiomer of 2,2-dichloro-3-(substituted phenyl)cyclopropane-carboxylic acid is prepared in a process involving chemical resolution of a racemic mixture of a trans-2,2-dichloro-3-(substituted phenyl)cyclopropanecarboxylic acid with an enantiomeric amine, isolation of a diastereomeric amine salt and finally treatment of the salt with an acid.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: March 26, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Nakyen Choy, Fangzheng Li
  • Patent number: 10239818
    Abstract: The present invention relates to a process for preparing a terephthalic diester by reacting terephthalic acid with at least one alcohol, wherein terephthalic acid is suspended in the alcohol in a dispersing tank, the preliminary suspension is passed from the dispersing tank into a reactor and converted in the presence of an esterification catalyst, a reaction suspension is drawn off from a region between the upper region and the lower region of the reactor, a first stream of the reaction suspension is recycled into the upper region of the reactor and a second stream of the reaction suspension is introduced into the lower region of the reactor, and the reaction suspension is thus mixed, wherein the stream drawn off and/or the first stream is passed through a heat exchanger outside the reactor and heated; and water of reaction is distilled off together with the vapor as alcohol-water azeotrope, the vapor is at least partly condensed, the condensate is separated into an aqueous phase and an organic phase and the
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: March 26, 2019
    Assignee: BASF SE
    Inventors: Armin Schraut, Martin Kaller, Rob Bronneberg, Jasmin Stammer, Martin Das, Gerrit Harnischmacher
  • Patent number: 10239819
    Abstract: A method for producing esters of an alpha, beta-unsaturated carboxylic acid are disclosed, the method includes reacting a three or four carbon beta-hydroxyalkanoate composition or mixtures thereof with a mono-alcohol under heating conditions to form a reaction product and distilling the reaction product to recover a composition containing at least fifty percent by weight of the ester of the alpha, beta-unsaturated carboxylic acid.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: March 26, 2019
    Assignee: CARGILL, INCORPORATED
    Inventors: Timothy Walter Abraham, Ravi R. Gokarn
  • Patent number: 10239820
    Abstract: Embodiments described herein provide a compound that may be used in a variety of applications such as corrosion inhibition, additives for metalworking, mining reagents, epoxy curatives, emulsifiers, fuel or lubricant additives, surfactant manufacture, acid scavengers and asphalt additives. The compound has the following structure: where R1 is a methoxy group, R2, R3, R4 and R5 are independently a hydrogen atom or an alkyl group, and R6 is an aminomethyl group.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: March 26, 2019
    Assignee: HUNTSMAN PETROCHEMICAL LLC
    Inventor: Donald H Champion
  • Patent number: 10239821
    Abstract: There is disclosed a process for the co-production of long chain ?-amino acid and long chain dibasic acid, comprising: (1) reacting long chain ketoacid derivative with hydroxylamine or subjecting ketoacid derivative to an ammoximation to yield oxime derivative; (2) subjecting oxime derivative to Beckmann rearrangement to yield a mixture of mixed amide derivatives; (3) hydrolyzing the mixed amide derivatives to produce long chain ?-amino acid and long chain dibasic acid.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: March 26, 2019
    Assignee: VITAWORKS IP, LLC
    Inventor: Songzhou Hu
  • Patent number: 10239822
    Abstract: There is disclosed a process for the separation of long chain dibasic acid and fatty acid, comprising: (1) reacting a mixture of long chain dibasic acid and fatty acid with ammonium hydroxide to form an insoluble ammonium salt of fatty acid and a soluble ammonium salt of long chain dibasic acid; (2) recovering the insoluble ammonium salt of fatty acid; and (3) adding an acid to the mother liquor of step (2) to obtain the long chain dibasic acid.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: March 26, 2019
    Assignee: VITAWORKS IP, LLC
    Inventor: Songzhou Hu
  • Patent number: 10239823
    Abstract: There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid in an aqueous solution of organic carboxylic acid by heating; (2) cooling the solution of step (1) to crystallize the long chain amino acid; and (3) recovering the long chain amino acid of step (2) by means of solid-liquid separation.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: March 26, 2019
    Assignee: VITAWORKS IP, LLC
    Inventors: Songzhou Hu, William S. Hu
  • Patent number: 10239824
    Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: March 26, 2019
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Junqi Li, Eric P. Gillis
  • Patent number: 10239825
    Abstract: The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 26, 2019
    Assignee: Auckland Uniservices Limited
    Inventors: James Wallace Sleigh, William Alexander Denny, Jiney Jose, Swarnalatha Akuratiya Gamage, Martyn Gregory Harvey, Logan James Voss
  • Patent number: 10239826
    Abstract: A method for producing isocyanates by reacting primary amines with phosgene in a stoichiometric excess in the gas phase, wherein the excess phosgene is subsequently recovered and recirculated back into the reaction. particular a method for the feedback-controlled recirculation of the recovered phosgene, particularly when the phosgene stream that should be recovered is distributed between multiple gas-phase reactors operated in parallel.
    Type: Grant
    Filed: July 12, 2016
    Date of Patent: March 26, 2019
    Assignee: COVESTRO DEUTSCHLAND AG
    Inventors: Friedhelm Steffens, Bastian Mahr
  • Patent number: 10239827
    Abstract: The present invention relates to novel processes for producing bis[3-isopropenyl-?,?-dimethylbenzyl]carbodiimide, to the thus-produced bis[3-isopropenyl-?,?-dimethylbenzyl]carbodiimide and to the use thereof as a hydrolysis inhibitor in polyurethane (PU)-based systems, preferably thermoplastic TPU, PU adhesives, PU casting resins, PU elastomers or PU foams.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: March 26, 2019
    Assignee: LANXESS Deutschland GmbH
    Inventors: Wilhelm Laufer, Martina Schoenhaber, Armin Eckert, Oliver Herd, Rolf Sperber
  • Patent number: 10239828
    Abstract: A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: March 26, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Jerald K. Rasmussen, George W. Griesgraber, James I. Hembre
  • Patent number: 10239829
    Abstract: The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: March 26, 2019
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Jorge E. Gomez-Galeno, Raja K. Reddy, Paul D. van Poelje, Robert Huerta Lemus, Thanh Huu Nguyen, Matthew P. Grote, Qun Dang, Scott J. Hecker, Venkat Reddy Mali, Mingwei Chen, Zhili Sun, Serge Henri Boyer, Haiqing Li, William Craigo
  • Patent number: 10239830
    Abstract: Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: March 26, 2019
    Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, The United States of America, as represented by the Secretary, Depart. of Health and Human Services
    Inventors: Samarjit Patnaik, Mercedes Taylor, Raul Rolando Calvo, Juan Jose Marugan, Noel Southall, Wei Zheng, Marc Ferrer-Alegre, Seameen Dehdasthi, Patricia Dranchak, Fannie Chen, Yiannis Ioannou
  • Patent number: 10239831
    Abstract: The present invention relates to a novel method for preparing bis(3-aminophenyl) disulphides of the general formula (I) and 3-aminothiols of the general formula (II), where X,Y have the meanings stated in the description, which serve as intermediates for the preparation of phenyl sulphoxides having insecticidal, acaricidal and nematicidal activity.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: March 26, 2019
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Thomas Himmler, Julia Johanna Hahn
  • Patent number: 10239832
    Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: March 26, 2019
    Assignee: BIOMARIN PHARMACEUTICAL INC.
    Inventor: Bing Wang
  • Patent number: 10239833
    Abstract: The present invention provides novel process for the preparation of the ?1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts indoline compounds, utilizing derivatives of Formula 1 and salts thereof.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: March 26, 2019
    Assignee: MANKIND PHARMA LTD.
    Inventors: Gurpreet Singh, Kuldeep Singh Gangwar, Bhuwan Bhashkar, Anil Kumar
  • Patent number: 10239834
    Abstract: The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: March 26, 2019
    Assignee: NEW MEXICO TECH UNIVERSITY RESEARCH PARK CORPORATION
    Inventors: Snezna Rogelj, Liliya Frolova, Alexander Kornienko, Leslie D. Edwards, Cody Champion, Kailee Zingler, Danielle Nicole Turner
  • Patent number: 10239835
    Abstract: The present invention relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment of neurological diseases having the Formula I where R1, R2, L1, L2, X, Y, and Y? are described therein. In an aspect, compounds of formula I are described and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or stereoisomers thereof wherein: L1 is straight or branched C1-C5 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, ORIO, NH2, NHRio, and N(Rlo)(Rio?) provided that no more than one oxygen or nitrogen is attached to any carbon.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: March 26, 2019
    Assignee: CADENT THERAPEUTICS, INC.
    Inventors: David R. Anderson, Robert A. Volkmann, Frank S. Menniti
  • Patent number: 10239836
    Abstract: The present invention relates to a novel analogs of benzenecarbothioccyclopenta[c]pyrrole-1,3-dione of formula (I) useful for treating various viral infections and process for synthesis thereof. The present invention provides a novel process for synthesis of nitrosporeusines A(1) and B(2). More particularly, the present invention provides a synthetic route for synthesis of nitrosporeusines A(1) and B(2). Said process is simple, industrially scalable, cost effective and eco-friendly.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: March 26, 2019
    Assignee: Council of Scientific & Industrial Research
    Inventors: Dumbala S. Reddy, Satish C. Philkhana, Gorakhnath R. Jachak, Vidya B. Gunjal
  • Patent number: 10239837
    Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: March 26, 2019
    Assignee: REGENACY PHARMACEUTICALS, LLC
    Inventors: John H. van Duzer, Ralph Mazitschek
  • Patent number: 10239838
    Abstract: The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: March 26, 2019
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Scott D. Kuduk, Nigel Liverton, Yunfu Luo
  • Patent number: 10239839
    Abstract: The present invention relates to compositions and methods of using free radical scavengers with reduced 1O2 generation. In certain embodiments, these compositions and methods of use relate to fullerene-derived ketolactams and fullerene-derived ketolactam derivatives, fullerene derivatives, and/or fullerenes. In yet other embodiments, the invention relates to cosmetic or dermatological compositions comprising said free radical scavengers with reduced 1O2 generation.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: March 26, 2019
    Assignee: Solenne BV
    Inventors: David F. Kronholm, Alexander B. Sieval, Jan C. Hummelen
  • Patent number: 10239840
    Abstract: Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: March 26, 2019
    Assignee: VIIV HEALTHCARE UK LIMITED
    Inventors: Brian Alvin Johns, Lita S. Suwandi, Emile Johann Velthuisen, Jason Gordon Weatherhead
  • Patent number: 10239841
    Abstract: The invention relates to a production method of pyrazole derivative (6) by reacting compound (5) with an oxidant. wherein R1, R2, R3, X1, X2 and Z1 are as defined herein.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: March 26, 2019
    Assignee: AGC Inc.
    Inventors: Yuichiro Ishibashi, Yosuke Ochi, Noriaki Miyake, Yusuke Yamazaki, Shota Shimizu
  • Patent number: 10239842
    Abstract: The present invention relates to hydrosoluble compounds derived from benzimidazole represented by general formula I: wherein: Y1 e Y2 are independently O or S, and at least one of Y1 and Y2 is O; R1 and R2 are independently hydrogen or a cation, both are hydrogen or both are cations; R3 is a C1-4 alkyl; R4 and R5 are independently halogen or a —OR6 alkoxide; R6 is C6-C10 aryl linked in 5- or 6-position of benzimidazole nucleus.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: March 26, 2019
    Assignee: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO
    Inventors: Rafael Castillo Bocanegra, Miguel Angel Flores Ramos, Maria Alicia Hernandez Campos, Osvaldo Froylan Ibarra Velarde, Remedios Yolanda Vera Montenegro
  • Patent number: 10239843
    Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: March 26, 2019
    Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
    Inventors: Alison E. McGonagle, Allan Jordan, Bohdan Waszkowycz, Colin Hutton, Ian Waddell, James R. Hitchin, Kate Mary Smith, Niall M. Hamilton
  • Patent number: 10239844
    Abstract: The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: March 26, 2019
    Assignee: BioVentures, LLC
    Inventors: Nikhil Reddy Madadi, Narsimha Reddy Penthala, Peter Crooks, Leena Maddukuri, Robert Eoff
  • Patent number: 10239845
    Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: March 26, 2019
    Assignee: Forma Therapeutics, Inc.
    Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin
  • Patent number: 10239846
    Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 26, 2019
    Assignee: CELGENE INTERNATIONAL II SÀRL
    Inventors: Esther Martinborough, Marcus F. Boehm, Adam Richard Yeager, Junko Tamiya, Liming Huang, Enugurthi Brahmachary, Manisha Moorjani, Gregg Alan Timony, Jennifer L. Brooks, Robert Peach, Fiona Lorraine Scott, Michael Allen Hanson
  • Patent number: 10239847
    Abstract: Provided herein is a composition, method of manufacture, and method for treating a disease condition and/or raising cellular levels of glutathione, the composition comprising L-2-oxothiazolidine-4-carboxylate, (procysteine) having a purity of at least 99 to 99.5 percent.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: March 26, 2019
    Assignee: Cellactin
    Inventors: Dustin Cefalo, Homayoun Mokri
  • Patent number: 10239848
    Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 26, 2019
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
  • Patent number: 10239849
    Abstract: In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: March 26, 2019
    Inventors: Michael T. Rudd, Edward J. Brnardic, Yuntae Kim, Robert S. Meissner, Vanessa L. Rada, Shawn J. Stachel, Celina V. Zerbinatti
  • Patent number: 10239850
    Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: March 26, 2019
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Charles N. Serhan, Rong Yang
  • Patent number: 10239851
    Abstract: The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I), wherein R1 is H or alkyl; X is H or F; Y is F or fluoroalkyl; n is 0, 1, 2, 3, 4, 5, or 6; W is W1 or W2; W1 is NR2R3, NR2R3.A, R2 and R3 are each independently H, alkyl, cycloalkyl, or a protecting group for amino; m is 0, 1, 2, or 3; A is an acid; W2 is COOR4, OPO(OR4)2, or PO(OR)2; R4 is H, or a protecting group for carboxyl or hydroxyl in phosphoric acid.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: March 26, 2019
    Inventor: Qingeng Li
  • Patent number: 10239852
    Abstract: A process for the transformation of a feed of at least one sugar into 5-hydroxymethylfurfural, contacting the feed with one or more organic catalysts in the presence of at least one solvent, said solvent being water or an organic solvent, alone or as a mixture, at a temperature in the range 30° C. to 200° C., and at a pressure in the range 0.1 MPa to 10 MPa, in which said organic catalysts are selected from compounds from the thiourea family with general formula R1NH—C(?S)—NHR2, in which the groups R1 and R2 are aromatic groups optionally having a heteroatom, linear or branched alkyl groups, which may or may not be cyclic, and alkyl groups with at least one heteroatom, which may be linear or branched, which may or may not be cyclic, said groups R1 and R2 possibly being substituted or unsubstituted and which may be identical or different.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: March 26, 2019
    Assignee: IFP Energies nouvelles
    Inventors: Myriam Souleymanou, Damien Delcroix
  • Patent number: 10239853
    Abstract: The present invention is generally directed to fluorescent dyes useful for preparing fluorescent oligonucleotides, and the use of the fluorescent oligonucleotides for the detection, discrimination and quantification of molecular biology targets.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: March 26, 2019
    Assignee: AAT Bioquest, Inc.
    Inventors: Zhenjun Diwu, Ruogu Peng, Haitao Guo, Zhen Luo
  • Patent number: 10239854
    Abstract: The inventive subject matter provides compounds, compositions and methods for lowering serum acid (sUA) for the treatment of gout, and having reduced liver toxicity, associated with CYP2C9 metabolic pathway.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: March 26, 2019
    Assignee: ARTHROSI THERAPEUTICS, INC.
    Inventors: Shunqi Yan, Li-Tain Yeh, Robert Orr
  • Patent number: 10239855
    Abstract: A process for preparing oroxylin A includes: subjecting baicalin to a methylation reaction using a methylating reagent in the presence of a base to methylate the 6-hydroxyl group of baicalin, so as to form a methylated compound; and subjecting the methylated compound to a deglucuronidation reaction in the presence of an acid, so as to form oroxylin A.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: March 26, 2019
    Assignee: CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE
    Inventors: Kuan-Han Lee, Wen-Yeuh Ho, Clay Chia-Chun Wang
  • Patent number: 10239856
    Abstract: Disclosed are macrocyclic compounds of formulae I, I?, II, II?, III, III?, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: March 26, 2019
    Assignee: UNIVERSITY DE STRASBOURG
    Inventors: Nicolas Winssinger, Sofia Barluenga, Martin Karplus