Patents Issued in March 26, 2019
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Patent number: 10239807Abstract: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.Type: GrantFiled: December 22, 2015Date of Patent: March 26, 2019Assignee: SynAffix B.V.Inventors: Floris Louis Van Delft, Floris Petrus Johannes Theodorus Rutjes, Frederik Jan Dommerholt
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Patent number: 10239808Abstract: A method is provided for removing THC from raw cannabis oil.Type: GrantFiled: December 7, 2017Date of Patent: March 26, 2019Assignee: Canopy Holdings, LLCInventors: Jacob Black, Ryan Beigie, Alex Mateo
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Patent number: 10239809Abstract: New methods of preparing bridged bi-aromatic ligands are disclosed. The methods employ direct di-ortho-lithiation of aromatic rings of bridged protected bi-aromatic diphenols. The ligands may be used to prepare transition metal compounds useful as catalysts in olefin polymerization.Type: GrantFiled: April 19, 2016Date of Patent: March 26, 2019Assignee: Univation Technologies, LLCInventors: Catherine Anne Faler, C. Jeff Harlan, Kevin P. Ramirez
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Patent number: 10239810Abstract: The process of the invention is a process for the production of an aldehyde from the corresponding alcohol comprising the steps of feeding to a reactor a feed stream comprising said alcohol and an oxygen-containing gas; reacting said alcohol in the gas phase with said oxygen-containing gas in said reactor in the presence of a catalyst comprising oxides of iron and molybdenum, wherein the process further comprises the step of adding water to said feed stream. The process is particularly useful for the production of formaldehyde by the oxidation of methanol.Type: GrantFiled: April 28, 2016Date of Patent: March 26, 2019Assignee: Johnson Matthey Public Limited CompanyInventor: Johan Björn Mattias Holmberg
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Patent number: 10239811Abstract: A process for producing reduced coenzyme Q10 includes removing moisture from an aqueous suspension including a reduced coenzyme Q10-containing microbial cell or a disrupted cell thereof such that a de-moisturized substance is obtained and in contact with an oxidizing atmosphere, and that an oxidized coenzyme Q10 is produced in an amount of 50 mass % or more relative to a total amount of the oxidized and reduced coenzymes Q10, and reducing the oxidized coenzyme Q10 outside a microbial cell such that a reduced coenzyme Q10 is recovered.Type: GrantFiled: December 22, 2017Date of Patent: March 26, 2019Assignee: KANEKA CORPORATIONInventors: Kento Kanaya, Hiroko Okatsu
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Patent number: 10239812Abstract: Embodiments herein relate to apparatus and systems for phenolic and ketone synthesis and methods regarding the same. In an embodiment, a method of producing phenolics and ketones is included. The method can specifically include forming a reaction mixture comprising nanocrystalline cellulose (NCC) and water. The method can also include contacting the reaction mixture with a metal oxide catalyst at a temperature of 350 degrees Celsius or higher and a pressure of at least about 3200 psi to form a reaction product mixture. The reaction product mixture can include at least about 20 wt. % phenolics and at least about 10 wt. % ketones as a percentage of the total mass of nanocrystalline cellulose (NCC). Other embodiments are also included herein.Type: GrantFiled: April 26, 2018Date of Patent: March 26, 2019Assignee: SarTec CorporationInventors: Ronald Leigh Fedie, Bingwen Yan, Larry C. McNeff, Peter G. Greuel, Clayton V. McNeff
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Patent number: 10239813Abstract: The invention relates to a method for the production of calcium dipropionate by a batch process in a single pressure-resistant reaction vessel. The reaction vessel is charged with calcium oxide, calcium hydroxide, calcium carbonate or a mixture thereof. Then, pure high-concentrated propionic acid, preferably in a concentration of above 99% is added to the solid raw materials. The heat (up to 160° C.) and pressure (up to 10 bar) are retained in the reaction vessel and are subsequently used to discharge the reaction water after the complete amount of acid has been added. After a reaction time of 3 to 6 hours, pure calcium dipropionate with a water content of below 1% is obtained.Type: GrantFiled: July 6, 2016Date of Patent: March 26, 2019Assignee: Addcon Europe GMBHInventors: Klaus Ederle-Lerch, Norman Killian, Bernd Kochannek, Hans-Jürgen Stüwe
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Patent number: 10239814Abstract: A process for the purification of levulinic acid including the following steps: a. providing a composition 1, comprising at least 75 wt. % of levulinic acid; b. cooling composition 1 to at least one temperature Tc, wherein Tc is a temperature in the range 1.23*(W1)?104.5?Tc (° C.)?1.23*(W1)?89.5, wherein W1 is the weight % of levulinic acid in composition 1, to obtain a cooled composition 1; c. performing melt crystallization of composition 1 including the steps of: i. bringing the cooled composition 1 into contact with levulinic acid crystal seeds, ii. allowing the levulinic acid in composition 1 to crystallize at at least one temperature Tc to obtain crystals 1 and liquid 1, and iii. draining of liquid 1; d. optionally, treating crystals 1, after draining of liquid 1, by sweating, according to the following steps: i. heating the crystals 1 at a temperature between 5 and 40° C. to obtain crystals 2 and liquid 2, and ii. draining of liquid 2; e.Type: GrantFiled: October 11, 2016Date of Patent: March 26, 2019Assignee: GFBIOCHEMICALS IP ASSETS B.V.Inventors: Aris De Rijke, Rudy Francois Maria Jozef Parton, Donato Santoro, Barthel Engendahl
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Patent number: 10239815Abstract: The objective of the present invention is to provide a method for efficiently producing acrylic acid while troubles not only in a waste oil handling after distillation of acrylic acid but also in a purification system of acrylic acid during distillation are reduced. The method for producing acrylic acid according to the present invention is characterized in comprising the step of supplying at least crude acrylic acid and an alcohol solvent to an acrylic acid distillation apparatus to distill acrylic acid, wherein a boiling point of the alcohol solvent is higher than a boiling point of acrylic acid by not lower than 50° C.Type: GrantFiled: January 26, 2016Date of Patent: March 26, 2019Assignee: NIPPON SHOKUBAI CO., LTD.Inventors: Toyofumi Sakai, Masashi Mukae, Yasutaka Takemoto
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Patent number: 10239816Abstract: The invention is directed to a process for recovering/purifying (meth)acrylic acid which does not use azeotropic solvent and is based on the use of two columns for purifying a reaction mixture comprising (meth)acrylic acid. The process according to the invention includes a dry vacuum pump condensation system, which makes it possible to reduce the amount of final aqueous discharges.Type: GrantFiled: March 4, 2016Date of Patent: March 26, 2019Assignee: Arkema FranceInventors: Sandeep Jain, Christian Lacroix, Michel Jean Fauconet
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Patent number: 10239817Abstract: The (1R,3R)- or (1S,3S)-enantiomer of 2,2-dichloro-3-(substituted phenyl)cyclopropane-carboxylic acid is prepared in a process involving chemical resolution of a racemic mixture of a trans-2,2-dichloro-3-(substituted phenyl)cyclopropanecarboxylic acid with an enantiomeric amine, isolation of a diastereomeric amine salt and finally treatment of the salt with an acid.Type: GrantFiled: October 9, 2017Date of Patent: March 26, 2019Assignee: Dow AgroSciences LLCInventors: Nakyen Choy, Fangzheng Li
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Patent number: 10239818Abstract: The present invention relates to a process for preparing a terephthalic diester by reacting terephthalic acid with at least one alcohol, wherein terephthalic acid is suspended in the alcohol in a dispersing tank, the preliminary suspension is passed from the dispersing tank into a reactor and converted in the presence of an esterification catalyst, a reaction suspension is drawn off from a region between the upper region and the lower region of the reactor, a first stream of the reaction suspension is recycled into the upper region of the reactor and a second stream of the reaction suspension is introduced into the lower region of the reactor, and the reaction suspension is thus mixed, wherein the stream drawn off and/or the first stream is passed through a heat exchanger outside the reactor and heated; and water of reaction is distilled off together with the vapor as alcohol-water azeotrope, the vapor is at least partly condensed, the condensate is separated into an aqueous phase and an organic phase and theType: GrantFiled: September 21, 2015Date of Patent: March 26, 2019Assignee: BASF SEInventors: Armin Schraut, Martin Kaller, Rob Bronneberg, Jasmin Stammer, Martin Das, Gerrit Harnischmacher
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Patent number: 10239819Abstract: A method for producing esters of an alpha, beta-unsaturated carboxylic acid are disclosed, the method includes reacting a three or four carbon beta-hydroxyalkanoate composition or mixtures thereof with a mono-alcohol under heating conditions to form a reaction product and distilling the reaction product to recover a composition containing at least fifty percent by weight of the ester of the alpha, beta-unsaturated carboxylic acid.Type: GrantFiled: October 15, 2015Date of Patent: March 26, 2019Assignee: CARGILL, INCORPORATEDInventors: Timothy Walter Abraham, Ravi R. Gokarn
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Patent number: 10239820Abstract: Embodiments described herein provide a compound that may be used in a variety of applications such as corrosion inhibition, additives for metalworking, mining reagents, epoxy curatives, emulsifiers, fuel or lubricant additives, surfactant manufacture, acid scavengers and asphalt additives. The compound has the following structure: where R1 is a methoxy group, R2, R3, R4 and R5 are independently a hydrogen atom or an alkyl group, and R6 is an aminomethyl group.Type: GrantFiled: December 1, 2015Date of Patent: March 26, 2019Assignee: HUNTSMAN PETROCHEMICAL LLCInventor: Donald H Champion
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Patent number: 10239821Abstract: There is disclosed a process for the co-production of long chain ?-amino acid and long chain dibasic acid, comprising: (1) reacting long chain ketoacid derivative with hydroxylamine or subjecting ketoacid derivative to an ammoximation to yield oxime derivative; (2) subjecting oxime derivative to Beckmann rearrangement to yield a mixture of mixed amide derivatives; (3) hydrolyzing the mixed amide derivatives to produce long chain ?-amino acid and long chain dibasic acid.Type: GrantFiled: December 17, 2015Date of Patent: March 26, 2019Assignee: VITAWORKS IP, LLCInventor: Songzhou Hu
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Patent number: 10239822Abstract: There is disclosed a process for the separation of long chain dibasic acid and fatty acid, comprising: (1) reacting a mixture of long chain dibasic acid and fatty acid with ammonium hydroxide to form an insoluble ammonium salt of fatty acid and a soluble ammonium salt of long chain dibasic acid; (2) recovering the insoluble ammonium salt of fatty acid; and (3) adding an acid to the mother liquor of step (2) to obtain the long chain dibasic acid.Type: GrantFiled: August 23, 2017Date of Patent: March 26, 2019Assignee: VITAWORKS IP, LLCInventor: Songzhou Hu
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Patent number: 10239823Abstract: There is disclosed a process for the purification of long chain amino acids by recrystallization in an aqueous solution of organic carboxylic acid in the absence or presence of solvent, comprising: (1) dissolving a long chain amino acid in an aqueous solution of organic carboxylic acid by heating; (2) cooling the solution of step (1) to crystallize the long chain amino acid; and (3) recovering the long chain amino acid of step (2) by means of solid-liquid separation.Type: GrantFiled: August 25, 2017Date of Patent: March 26, 2019Assignee: VITAWORKS IP, LLCInventors: Songzhou Hu, William S. Hu
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Patent number: 10239824Abstract: Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.Type: GrantFiled: July 11, 2016Date of Patent: March 26, 2019Assignee: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, Junqi Li, Eric P. Gillis
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Patent number: 10239825Abstract: The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).Type: GrantFiled: March 20, 2017Date of Patent: March 26, 2019Assignee: Auckland Uniservices LimitedInventors: James Wallace Sleigh, William Alexander Denny, Jiney Jose, Swarnalatha Akuratiya Gamage, Martyn Gregory Harvey, Logan James Voss
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Patent number: 10239826Abstract: A method for producing isocyanates by reacting primary amines with phosgene in a stoichiometric excess in the gas phase, wherein the excess phosgene is subsequently recovered and recirculated back into the reaction. particular a method for the feedback-controlled recirculation of the recovered phosgene, particularly when the phosgene stream that should be recovered is distributed between multiple gas-phase reactors operated in parallel.Type: GrantFiled: July 12, 2016Date of Patent: March 26, 2019Assignee: COVESTRO DEUTSCHLAND AGInventors: Friedhelm Steffens, Bastian Mahr
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Patent number: 10239827Abstract: The present invention relates to novel processes for producing bis[3-isopropenyl-?,?-dimethylbenzyl]carbodiimide, to the thus-produced bis[3-isopropenyl-?,?-dimethylbenzyl]carbodiimide and to the use thereof as a hydrolysis inhibitor in polyurethane (PU)-based systems, preferably thermoplastic TPU, PU adhesives, PU casting resins, PU elastomers or PU foams.Type: GrantFiled: June 3, 2015Date of Patent: March 26, 2019Assignee: LANXESS Deutschland GmbHInventors: Wilhelm Laufer, Martina Schoenhaber, Armin Eckert, Oliver Herd, Rolf Sperber
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Patent number: 10239828Abstract: A process for preparing guanidino-functional, free radically polymerizable compounds comprises (a) combining (1) an amine compound comprising (i) at least one primary aliphatic amino group and (ii) at least one secondary aliphatic amino group, primary aromatic amino group, or secondary aromatic amino group, and (2) a guanylating agent; (b) allowing or inducing reaction of the amine compound and the guanylating agent to form a guanylated amine compound; (c) combining (1) the guanylated amine compound, and (2) a reactive monomer comprising (i) at least one ethylenically unsaturated group and (ii) at least one group that is reactive with an amino group; and (d) allowing or inducing reaction of the guanylated amine compound and the reactive monomer to form a guanidino-functional, free radically polymerizable compound.Type: GrantFiled: March 15, 2017Date of Patent: March 26, 2019Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, George W. Griesgraber, James I. Hembre
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Patent number: 10239829Abstract: The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.Type: GrantFiled: June 5, 2017Date of Patent: March 26, 2019Assignee: Metabasis Therapeutics, Inc.Inventors: Jorge E. Gomez-Galeno, Raja K. Reddy, Paul D. van Poelje, Robert Huerta Lemus, Thanh Huu Nguyen, Matthew P. Grote, Qun Dang, Scott J. Hecker, Venkat Reddy Mali, Mingwei Chen, Zhili Sun, Serge Henri Boyer, Haiqing Li, William Craigo
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Patent number: 10239830Abstract: Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides.Type: GrantFiled: February 11, 2016Date of Patent: March 26, 2019Assignees: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, The United States of America, as represented by the Secretary, Depart. of Health and Human ServicesInventors: Samarjit Patnaik, Mercedes Taylor, Raul Rolando Calvo, Juan Jose Marugan, Noel Southall, Wei Zheng, Marc Ferrer-Alegre, Seameen Dehdasthi, Patricia Dranchak, Fannie Chen, Yiannis Ioannou
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Patent number: 10239831Abstract: The present invention relates to a novel method for preparing bis(3-aminophenyl) disulphides of the general formula (I) and 3-aminothiols of the general formula (II), where X,Y have the meanings stated in the description, which serve as intermediates for the preparation of phenyl sulphoxides having insecticidal, acaricidal and nematicidal activity.Type: GrantFiled: May 10, 2018Date of Patent: March 26, 2019Assignee: BAYER CROPSCIENCE AGInventors: Thomas Himmler, Julia Johanna Hahn
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Patent number: 10239832Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and compounds I for use to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).Type: GrantFiled: October 28, 2014Date of Patent: March 26, 2019Assignee: BIOMARIN PHARMACEUTICAL INC.Inventor: Bing Wang
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Patent number: 10239833Abstract: The present invention provides novel process for the preparation of the ?1-adrenoceptor antagonists, Silodosin and its pharmaceutically acceptable salts indoline compounds, utilizing derivatives of Formula 1 and salts thereof.Type: GrantFiled: December 5, 2017Date of Patent: March 26, 2019Assignee: MANKIND PHARMA LTD.Inventors: Gurpreet Singh, Kuldeep Singh Gangwar, Bhuwan Bhashkar, Anil Kumar
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Patent number: 10239834Abstract: The present disclosure describes a method to treat conditions, including bacterial infections and cancer, using a photosensitive compound that, upon exposure to white light, can be activated. The photosensitive compound can also interact synergistically with antibiotics used concomitantly to kill drug-resistant bacteria. The photosensitive compounds can also be used to inhibit the proliferation of cancer cells.Type: GrantFiled: October 31, 2017Date of Patent: March 26, 2019Assignee: NEW MEXICO TECH UNIVERSITY RESEARCH PARK CORPORATIONInventors: Snezna Rogelj, Liliya Frolova, Alexander Kornienko, Leslie D. Edwards, Cody Champion, Kailee Zingler, Danielle Nicole Turner
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Patent number: 10239835Abstract: The present invention relates to N-alkylaryl-5-oxyaryl-octadihydrocyclopent[c]pyrrole negative allosteric modulators of NR2B receptors useful in the treatment of neurological diseases having the Formula I where R1, R2, L1, L2, X, Y, and Y? are described therein. In an aspect, compounds of formula I are described and pharmaceutically acceptable salts, prodrugs, solvates, hydrates, tautomers, or stereoisomers thereof wherein: L1 is straight or branched C1-C5 alkyl optionally substituted with one or more substituents selected from the group consisting of OH, ORIO, NH2, NHRio, and N(Rlo)(Rio?) provided that no more than one oxygen or nitrogen is attached to any carbon.Type: GrantFiled: September 23, 2015Date of Patent: March 26, 2019Assignee: CADENT THERAPEUTICS, INC.Inventors: David R. Anderson, Robert A. Volkmann, Frank S. Menniti
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Patent number: 10239836Abstract: The present invention relates to a novel analogs of benzenecarbothioccyclopenta[c]pyrrole-1,3-dione of formula (I) useful for treating various viral infections and process for synthesis thereof. The present invention provides a novel process for synthesis of nitrosporeusines A(1) and B(2). More particularly, the present invention provides a synthetic route for synthesis of nitrosporeusines A(1) and B(2). Said process is simple, industrially scalable, cost effective and eco-friendly.Type: GrantFiled: October 1, 2015Date of Patent: March 26, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Dumbala S. Reddy, Satish C. Philkhana, Gorakhnath R. Jachak, Vidya B. Gunjal
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Patent number: 10239837Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC1 and/or HDAC2 activity.Type: GrantFiled: September 29, 2017Date of Patent: March 26, 2019Assignee: REGENACY PHARMACEUTICALS, LLCInventors: John H. van Duzer, Ralph Mazitschek
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Patent number: 10239838Abstract: The present invention is directed to heteroaryl compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.Type: GrantFiled: December 14, 2015Date of Patent: March 26, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Scott D. Kuduk, Nigel Liverton, Yunfu Luo
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Patent number: 10239839Abstract: The present invention relates to compositions and methods of using free radical scavengers with reduced 1O2 generation. In certain embodiments, these compositions and methods of use relate to fullerene-derived ketolactams and fullerene-derived ketolactam derivatives, fullerene derivatives, and/or fullerenes. In yet other embodiments, the invention relates to cosmetic or dermatological compositions comprising said free radical scavengers with reduced 1O2 generation.Type: GrantFiled: October 25, 2016Date of Patent: March 26, 2019Assignee: Solenne BVInventors: David F. Kronholm, Alexander B. Sieval, Jan C. Hummelen
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Patent number: 10239840Abstract: Compounds of Formula I are disclosed and methods of treating viral infections with compositions comprising such compounds.Type: GrantFiled: September 14, 2016Date of Patent: March 26, 2019Assignee: VIIV HEALTHCARE UK LIMITEDInventors: Brian Alvin Johns, Lita S. Suwandi, Emile Johann Velthuisen, Jason Gordon Weatherhead
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Patent number: 10239841Abstract: The invention relates to a production method of pyrazole derivative (6) by reacting compound (5) with an oxidant. wherein R1, R2, R3, X1, X2 and Z1 are as defined herein.Type: GrantFiled: March 23, 2016Date of Patent: March 26, 2019Assignee: AGC Inc.Inventors: Yuichiro Ishibashi, Yosuke Ochi, Noriaki Miyake, Yusuke Yamazaki, Shota Shimizu
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Patent number: 10239842Abstract: The present invention relates to hydrosoluble compounds derived from benzimidazole represented by general formula I: wherein: Y1 e Y2 are independently O or S, and at least one of Y1 and Y2 is O; R1 and R2 are independently hydrogen or a cation, both are hydrogen or both are cations; R3 is a C1-4 alkyl; R4 and R5 are independently halogen or a —OR6 alkoxide; R6 is C6-C10 aryl linked in 5- or 6-position of benzimidazole nucleus.Type: GrantFiled: November 25, 2015Date of Patent: March 26, 2019Assignee: UNIVERSIDAD NACIONAL AUTONOMA DE MEXICOInventors: Rafael Castillo Bocanegra, Miguel Angel Flores Ramos, Maria Alicia Hernandez Campos, Osvaldo Froylan Ibarra Velarde, Remedios Yolanda Vera Montenegro
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Patent number: 10239843Abstract: The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.Type: GrantFiled: December 11, 2015Date of Patent: March 26, 2019Assignee: CANCER RESEARCH TECHNOLOGY LIMITEDInventors: Alison E. McGonagle, Allan Jordan, Bohdan Waszkowycz, Colin Hutton, Ian Waddell, James R. Hitchin, Kate Mary Smith, Niall M. Hamilton
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Patent number: 10239844Abstract: The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.Type: GrantFiled: March 1, 2018Date of Patent: March 26, 2019Assignee: BioVentures, LLCInventors: Nikhil Reddy Madadi, Narsimha Reddy Penthala, Peter Crooks, Leena Maddukuri, Robert Eoff
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Patent number: 10239845Abstract: The present disclosure relates to inhibitors of zinc-dependent histone deacetylases (HDACs) useful in the treatment of diseases or disorders associated with an HDAC, e.g., HDAC6, having a Formula I: where R, L, X1, X2, X3, X4, Y1, Y2, Y3, and Y4 are described herein.Type: GrantFiled: February 2, 2016Date of Patent: March 26, 2019Assignee: Forma Therapeutics, Inc.Inventors: Xiaozhang Zheng, Pui Yee Ng, Bingsong Han, Jennifer R. Thomason, Mary-Margaret Zablocki, Cuixian Liu, Aleksandra Rudnitskaya, David R. Lancia, Jr., David S. Millan, Matthew W. Martin
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Patent number: 10239846Abstract: Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.Type: GrantFiled: January 13, 2017Date of Patent: March 26, 2019Assignee: CELGENE INTERNATIONAL II SÀRLInventors: Esther Martinborough, Marcus F. Boehm, Adam Richard Yeager, Junko Tamiya, Liming Huang, Enugurthi Brahmachary, Manisha Moorjani, Gregg Alan Timony, Jennifer L. Brooks, Robert Peach, Fiona Lorraine Scott, Michael Allen Hanson
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Patent number: 10239847Abstract: Provided herein is a composition, method of manufacture, and method for treating a disease condition and/or raising cellular levels of glutathione, the composition comprising L-2-oxothiazolidine-4-carboxylate, (procysteine) having a purity of at least 99 to 99.5 percent.Type: GrantFiled: March 3, 2017Date of Patent: March 26, 2019Assignee: CellactinInventors: Dustin Cefalo, Homayoun Mokri
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Patent number: 10239848Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.Type: GrantFiled: November 22, 2017Date of Patent: March 26, 2019Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Ruth Gallily, Raphael Mechoulam, Aviva Breuer
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Patent number: 10239849Abstract: In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.Type: GrantFiled: November 7, 2016Date of Patent: March 26, 2019Inventors: Michael T. Rudd, Edward J. Brnardic, Yuntae Kim, Robert S. Meissner, Vanessa L. Rada, Shawn J. Stachel, Celina V. Zerbinatti
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Patent number: 10239850Abstract: The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, identification, purification and uses thereof.Type: GrantFiled: February 20, 2017Date of Patent: March 26, 2019Assignee: The Brigham and Women's Hospital, Inc.Inventors: Charles N. Serhan, Rong Yang
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Patent number: 10239851Abstract: The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I), wherein R1 is H or alkyl; X is H or F; Y is F or fluoroalkyl; n is 0, 1, 2, 3, 4, 5, or 6; W is W1 or W2; W1 is NR2R3, NR2R3.A, R2 and R3 are each independently H, alkyl, cycloalkyl, or a protecting group for amino; m is 0, 1, 2, or 3; A is an acid; W2 is COOR4, OPO(OR4)2, or PO(OR)2; R4 is H, or a protecting group for carboxyl or hydroxyl in phosphoric acid.Type: GrantFiled: February 16, 2015Date of Patent: March 26, 2019Inventor: Qingeng Li
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Patent number: 10239852Abstract: A process for the transformation of a feed of at least one sugar into 5-hydroxymethylfurfural, contacting the feed with one or more organic catalysts in the presence of at least one solvent, said solvent being water or an organic solvent, alone or as a mixture, at a temperature in the range 30° C. to 200° C., and at a pressure in the range 0.1 MPa to 10 MPa, in which said organic catalysts are selected from compounds from the thiourea family with general formula R1NH—C(?S)—NHR2, in which the groups R1 and R2 are aromatic groups optionally having a heteroatom, linear or branched alkyl groups, which may or may not be cyclic, and alkyl groups with at least one heteroatom, which may be linear or branched, which may or may not be cyclic, said groups R1 and R2 possibly being substituted or unsubstituted and which may be identical or different.Type: GrantFiled: July 19, 2016Date of Patent: March 26, 2019Assignee: IFP Energies nouvellesInventors: Myriam Souleymanou, Damien Delcroix
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Patent number: 10239853Abstract: The present invention is generally directed to fluorescent dyes useful for preparing fluorescent oligonucleotides, and the use of the fluorescent oligonucleotides for the detection, discrimination and quantification of molecular biology targets.Type: GrantFiled: June 12, 2018Date of Patent: March 26, 2019Assignee: AAT Bioquest, Inc.Inventors: Zhenjun Diwu, Ruogu Peng, Haitao Guo, Zhen Luo
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Patent number: 10239854Abstract: The inventive subject matter provides compounds, compositions and methods for lowering serum acid (sUA) for the treatment of gout, and having reduced liver toxicity, associated with CYP2C9 metabolic pathway.Type: GrantFiled: October 4, 2018Date of Patent: March 26, 2019Assignee: ARTHROSI THERAPEUTICS, INC.Inventors: Shunqi Yan, Li-Tain Yeh, Robert Orr
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Patent number: 10239855Abstract: A process for preparing oroxylin A includes: subjecting baicalin to a methylation reaction using a methylating reagent in the presence of a base to methylate the 6-hydroxyl group of baicalin, so as to form a methylated compound; and subjecting the methylated compound to a deglucuronidation reaction in the presence of an acid, so as to form oroxylin A.Type: GrantFiled: August 25, 2017Date of Patent: March 26, 2019Assignee: CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCEInventors: Kuan-Han Lee, Wen-Yeuh Ho, Clay Chia-Chun Wang
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Patent number: 10239856Abstract: Disclosed are macrocyclic compounds of formulae I, I?, II, II?, III, III?, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.Type: GrantFiled: April 21, 2015Date of Patent: March 26, 2019Assignee: UNIVERSITY DE STRASBOURGInventors: Nicolas Winssinger, Sofia Barluenga, Martin Karplus